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Is restless legs syndrome related with depression/anxiety disorders or medications used in these disorders? A cross-sectional, clinic-based study 不宁腿综合征是否与抑郁/焦虑障碍或治疗这些障碍的药物有关?一项基于临床的横断面研究
IF 0.7 4区 医学 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2019-10-02 DOI: 10.1080/24750573.2019.1673943
Davut Ocak, V. O. Kotan, S. Paltun, M. C. Aydemir
ABSTRACT Objective: The aim of this study is to investigate the frequency and severity of restless legs syndrome (RLS) in patients diagnosed with depression or anxiety disorder and the relationship of RLS with medications used in these disorders and clinical/sociodemographic characteristics of the patients. Methods: Four hundred and fifty-four consecutive patients who were treated with medication for “Depressive Disorder” or “Anxiety Disorder” in our outpatient clinic were included in the study. Subjects were screened by International Restless Legs Syndrome Study Group (IRLSSG) scale, Hospital Anxiety Depression Scale. Patients who met the criteria of RLS diagnosis due to the RLS screening scale (n = 104) were interviewed in detail. Patients’ laboratory tests were performed to investigate medical conditions other than antidepressant/antipsychotic use known to be related with RLS and 40 (8.8%) of 104 patients were excluded from the study. The main study group consisted of 414 patients. Results: The mean IRLSSG score of 64 patients diagnosed with RLS was 18.95 ± 5.11 (min: 7–max: 29), 7.8% of whom had mild and 55.1% had severe RLS. The incidence of RLS in patients receiving antidepressant treatment (n: 414) was significantly higher than the general population (15.5%). There were no significant difference neither between diagnostic groups (anxiety/ depression) nor individual antidepressants by means of RLS. Patients receiving combined treatment like SSRI + quetiapine, SSRI + mirtazapine or SSRI + trazodone scored 4.7 times higher on RLS scale. Discussion: There was no significant difference by means of RLS diagnosis or severity of RLS in patients with a diagnosis of anxiety/depressive disorder. However antidepressant using patients’ RLS prevalence was higher than general population’s. It was noticed that patients who received combined drug treatment had a 4.7-fold increase in RLS. In conclusion; beginning with as possible as the least number and dose of psychotropic drugs when treating a patient with depression or anxiety disorder does not increase RLS risk as well as providing advantages such as reduced risk of drug interaction and side effects.
摘要目的:本研究旨在调查诊断为抑郁或焦虑障碍患者的不宁腿综合征(RLS)的频率和严重程度,以及RLS与这些疾病使用的药物和患者临床/社会人口学特征的关系。方法:在我院门诊连续接受“抑郁障碍”或“焦虑障碍”药物治疗的454例患者纳入研究。采用国际不宁腿综合征研究组(IRLSSG)量表、医院焦虑抑郁量表对受试者进行筛选。通过RLS筛查量表对符合RLS诊断标准的患者(n = 104)进行详细访谈。对患者进行实验室检查,以调查已知与RLS相关的抗抑郁药/抗精神病药使用以外的医疗状况,104例患者中有40例(8.8%)被排除在研究之外。主要研究组由414例患者组成。结果:64例RLS患者的IRLSSG平均评分为18.95±5.11 (min: 7-max: 29),其中轻度RLS占7.8%,重度RLS占55.1%。接受抗抑郁治疗的患者的RLS发生率(n: 414)显著高于普通人群(15.5%)。在诊断组(焦虑/抑郁)和个体抗抑郁药之间通过RLS均无显著差异。接受SSRI +喹硫平、SSRI +米氮平或SSRI +曲唑酮联合治疗的患者在RLS量表上得分高出4.7倍。讨论:在诊断为焦虑/抑郁障碍的患者中,通过RLS诊断或RLS严重程度无显著差异。但使用抗抑郁药的患者的RLS患病率高于普通人群。值得注意的是,接受联合药物治疗的患者的RLS增加了4.7倍。结论;在治疗患有抑郁症或焦虑症的患者时,从尽可能少的数量和剂量的精神药物开始,不仅不会增加睡眠倒睡的风险,而且还提供了诸如减少药物相互作用和副作用的风险等优点。
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引用次数: 2
Relationships between teacher-reported ADHD symptom profiles and academic achievement domains in a nonreferred convenience sample of first- to fourth-grade students 在一至四年级学生的非参考样本中,教师报告的ADHD症状概况与学业成就领域之间的关系
IF 0.7 4区 医学 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2019-10-02 DOI: 10.1080/24750573.2018.1457488
Ö. Öner, Sinem Vatanartıran, Şirin Karadeniz
ABSTRACT OBJECTIVES: Previous studies suggested that inattention was related particularly with reading problems among students. However, most of the former studies had clinically referred samples. A majority of the studies conducted with nonreferred samples have evaluated academic achievement with single or a few parent- or teacher-rated items. Almost none of the studies have investigated reading, writing, and mathematics achievements in a single sample. Data from low- and middle-income countries on the subject are exceedingly scarce. Objectives of the present study were to compare actual measurements of reading fluency, reading comprehension, reading and writing errors, mathematics achievement, and teacher ratings of attention deficit hyperactivity disorder (ADHD) symptoms in a single sample. METHODS: Teachers rated ADHD symptoms in a single, nonreferred, population sample (n = 2493) of first- to fourth-grade students with a SNAP-4 rating scale. Actual measurements of reading fluency, reading comprehension, reading and writing errors, and mathematics achievement were also obtained. Fluid IQ was evaluated with Ravens Progressive Matrices. Students were grouped into Predominantly Inattentive (PI), Hyperactive/Impulsive (HI), Combined (C), or control groups. Univariate and multivariate analyses were conducted. Statistical significance was set at p < .003 after correction for multiple comparisons. RESULTS: We showed that after fluid IQ level and gender were controlled, ADHD-PI and ADHD-C groups (but not ADHD-HI) had significantly lower performance in all academic areas. ADHD-PI increased the risk of being in the lowest performing 10th percentile for reading 3 times, for writing more than 3.9 times, and for mathematics more than 6 times. CONCLUSIONS: We investigated the subtype differences in terms of academic achievement between ADHD-PI, ADHD-HI, and ADHD-C, based on teacher reports. Academic achivement data were not based on teacher or parent reports but on the actual performance of the students using standardized tests. Our results suggested that inattention symptoms must be targeted in primary school students in order to help them have academic achievement similar to their peers.
摘要目的:以往的研究表明,注意力不集中与学生的阅读问题密切相关。然而,大多数以前的研究有临床参考样本。大多数对非参考样本进行的研究都是用一个或几个家长或老师评价的项目来评估学业成绩。几乎没有一项研究将阅读、写作和数学成绩作为单一样本进行调查。来自低收入和中等收入国家关于这一问题的数据极其稀少。本研究的目的是比较单个样本中阅读流畅性、阅读理解、读写错误、数学成绩和教师对注意缺陷多动障碍(ADHD)症状的评价。方法:教师用SNAP-4评定量表对一至四年级学生的单一、非转诊人群样本(n = 2493)进行ADHD症状评定。阅读流畅性、阅读理解、读写错误和数学成绩的实际测量结果也得到了。用Ravens渐进式矩阵评价流体智商。学生被分为明显注意力不集中(PI)组、过度活跃/冲动(HI)组、混合型(C)组和对照组。进行单因素和多因素分析。p <有统计学意义。003经多次比较修正后。结果:我们发现,在控制流体智商水平和性别后,ADHD-PI组和ADHD-C组(但不包括ADHD-HI组)在所有学术领域的表现都明显较低。在阅读3次、写作超过3.9次、数学超过6次的测试中,患有多动症的人进入成绩最差的10%的风险增加了。结论:我们根据教师报告调查了ADHD-PI、ADHD-HI和ADHD-C在学业成就方面的亚型差异。学业成绩数据不是基于老师或家长的报告,而是基于学生在标准化考试中的实际表现。我们的研究结果表明,必须针对小学生的注意力不集中症状,以帮助他们取得与同龄人相似的学业成绩。
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引用次数: 9
Social cognition and emotion regulation may be impaired in adolescents with obesity independent of the presence of binge eating disorder: a two-center study 社会认知和情绪调节可能在青少年肥胖独立暴食障碍的存在受损:一项双中心研究
IF 0.7 4区 医学 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2019-10-02 DOI: 10.1080/24750573.2019.1693727
Serkan Turan, G. Özyurt, G. Çatlı, Y. Öztürk, A. Abacı, A. Akay
ABSTRACT Background: Binge eating disorder (BED) and obesity in adolescents is associated with variations in social cognition and emotion regulation. The current study aimed to evaluate the Theory of Mind (ToM) abilities in adolescents with obesity with and without BED and to examine how they related to emotional and psychopathologic evaluations. Methods: One hundred twenty-eight adolescents comprising 32 non-BED adolescents with obesity, 32 adolescents with BED and obesity, and 64 healthy controls (HC) completed a battery of tests to analyze their social cognition and clinical psychopathologic profile. Results: Patients with BED and non-BED patients with obesity showed poorer performance in emotional regulation and social cognition tasks compared with normal-weight adolescents without BED. Various correlations were evident between depression, emotional regulation problems, and eating attitudes and patterns. Conclusions: Patients with BED and non-BED adolescents with obesity showed a decline in ToM tasks, independent of their clinical psychopathological profile. Consistent with other studies, this is the first study to assess both social cognition and emotion regulation skills in adolescents with BED and obesity.
背景:青少年暴食症(BED)和肥胖与社会认知和情绪调节的变化有关。本研究旨在评估青少年肥胖者的心理理论(ToM)能力,并研究其与情绪和精神病理评估的关系。方法:128名青少年,包括32名非BED型青少年合并肥胖、32名BED型青少年合并肥胖和64名健康对照(HC),对他们的社会认知和临床精神病理特征进行了分析。结果:与体重正常的非BED青少年相比,BED患者和非BED肥胖患者在情绪调节和社会认知任务中的表现较差。抑郁症、情绪调节问题和饮食态度和模式之间的各种相关性都很明显。结论:患有BED和非BED的青少年肥胖患者在ToM任务中表现出下降,与他们的临床精神病理特征无关。与其他研究一致,这是第一个评估患有BED和肥胖的青少年的社会认知和情绪调节技能的研究。
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引用次数: 6
Control of seizures in a clozapine-treated schizophrenia patient, using valproate: a case report 丙戊酸对氯氮平治疗的精神分裂症患者癫痫发作的控制:1例报告
IF 0.7 4区 医学 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2019-10-02 DOI: 10.1080/24750573.2018.1468640
Hamza Ayaydın, Şermin Bilgen Ulgar
ABSTRACT Schizophrenia is characterized by an adverse clinical course and poor psychosocial functioning, and causes problems in the social-cognitive sphere. Clozapine is a potent antipsychotic agent used in the treatment of psychotic disorders when other antipsychotic agents failed. It is seen that clozapine causes more seizures at therapeutic doses when compared to standard antipsychotic agents. Various mechanisms have been proposed for seizure onset. Clozapine can induce epileptogenic activity by inhibiting D4 receptors in mesolimbic system and cortex. Clozapine does not only exert its effects on H1 and Ach-Mus receptors but also on several receptors such as gamma-aminobutyric acid A, nicotinic acetylcholine, glutamate, and N-methyl-D-aspartate. Here, we discussed a woman with schizophrenia in whom atonic seizure was developed during clozapine treatment and treated successfully by valproic acid/sodium valproate. Atonic seizures should be considered in patients who have drop attacks during clozapine therapy and atonic seizures should be treated by using an anticonvulsant agent such as valproic acid/sodium valproate when it is inappropriate to reduce clozapine dose.
精神分裂症的特点是不良的临床病程和不良的社会心理功能,并导致社会认知领域的问题。氯氮平是一种有效的抗精神病药物,当其他抗精神病药物失效时,用于治疗精神障碍。与标准抗精神病药物相比,氯氮平在治疗剂量下引起更多的癫痫发作。癫痫发作的各种机制已被提出。氯氮平可通过抑制中脑边缘系统和皮层的D4受体诱导致痫活性。氯氮平不仅对H1和Ach-Mus受体起作用,还对γ -氨基丁酸A、烟碱乙酰胆碱、谷氨酸和n -甲基- d -天冬氨酸等受体起作用。在这里,我们讨论了一位患有精神分裂症的女性,她在氯氮平治疗期间发生了失张力发作,并通过丙戊酸/丙戊酸钠成功治疗。在氯氮平治疗过程中,失张力发作应被考虑,当不适宜减少氯氮平剂量时,应使用抗惊厥药,如丙戊酸/丙戊酸钠。
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引用次数: 0
Syrian Civil War’s effects on Turkish school children: prevalence and predictors of psychopathology* 叙利亚内战对土耳其学龄儿童的影响:精神病理学的患病率和预测因素*
IF 0.7 4区 医学 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2019-10-02 DOI: 10.1080/24750573.2019.1661758
Sinem Tabur, A. Tufan, V. Çeri, B. Semerci
ABSTRACT Objectives: The Syrian Civil War forced millions into asylum in neighbouring countries. Refugees/asylum seekers have elevated risk for psychopathology with the most important being post-traumatic stress disorder (PTSD). Subjective experiences and symptoms of the hosting populations which have also experienced similar traumas have received relatively little attention up to now. We aimed to evaluate the effects of Syrian Civil War in terms of psychopathology, traumatic experiences and PTSD on Turkish primary school students living in Suruç which is on the border with Syria and hosts a large population of asylum seekers. Methods: Two randomly selected schools operating in the district were included in the study. Sociodemographic Data forms, Child Behaviour Checklist (CBCL), Children’s Post-traumatic Reaction Index (CPRI) were used for evaluations. Data were analysed with SPSS 23.0. P was set at 0.05 (two-tailed). Results: Most common traumatic experiences via parental report were witnessing explosions (26.9%), witnessing injuries of extended family/relatives (21.8%) and witnessing deaths of acquaintances (17.9%). Lifetime traumatic events and lifetime self-injurious behaviour in children via parental report were 26.9% and 19.9%; respectively. Of 156 students (53.2% male) with a mean age of 8.8 years (S.D. = 1.3), 13.5% obtained externalizing scores, 11.0% obtained internalizing scores and 13.5% obtained total scores in the clinical range of CBCL. 98.7% reported PTSD symptoms in moderate and above severity in CPRI. Most common traumatic experiences reported by children included hearing explosions/gunshots (17.3%), damage to residences (17.3%), and witnessing deaths of extended family/ acquaintances (12.8%). Female gender (p = .00), witnessing loss of family members/acquaintances in Syrian Civil War (p = .01) and clinically significant PTSD symptoms in CPRI. Conclusion: Children in communities hosting Syrian refugees/asylum seekers may also have elevated symptoms of PTSD and female gender may be a risk factor for those symptoms.
摘要目的:叙利亚内战迫使数百万人在邻国避难。难民/寻求庇护者患精神病理的风险较高,其中最重要的是创伤后应激障碍(PTSD)。迄今为止,也经历过类似创伤的收容人口的主观经历和症状得到的关注相对较少。我们的目的是评估叙利亚内战对居住在Suruç的土耳其小学生的精神病理学、创伤经历和创伤后应激障碍的影响,Suruç位于叙利亚边境,收容了大量寻求庇护者。方法:随机选取两所本区学校进行研究。采用社会人口学数据表、儿童行为检查表(CBCL)、儿童创伤后反应指数(CPRI)进行评估。数据采用SPSS 23.0进行分析。P值为0.05(双尾)。结果:父母报告中最常见的创伤经历是目睹爆炸(26.9%)、目睹大家庭/亲属受伤(21.8%)和目睹熟人死亡(17.9%)。通过父母报告的儿童一生创伤事件和一生自伤行为分别为26.9%和19.9%;分别。156名学生(53.2%)平均年龄8.8岁(S.D. = 1.3),在CBCL临床范围内获得外化得分的占13.5%,获得内化得分的占11.0%,获得总分的占13.5%。98.7%的CPRI患者有中度及以上的PTSD症状。儿童报告的最常见的创伤经历包括听到爆炸声/枪声(17.3%)、住宅受损(17.3%)和目睹大家庭/熟人死亡(12.8%)。女性(p = .00),在叙利亚内战中失去家庭成员/熟人(p = .01), CPRI患者有明显的PTSD临床症状。结论:叙利亚难民/寻求庇护者所在社区的儿童也可能有较高的创伤后应激障碍症状,女性可能是这些症状的危险因素。
{"title":"Syrian Civil War’s effects on Turkish school children: prevalence and predictors of psychopathology*","authors":"Sinem Tabur, A. Tufan, V. Çeri, B. Semerci","doi":"10.1080/24750573.2019.1661758","DOIUrl":"https://doi.org/10.1080/24750573.2019.1661758","url":null,"abstract":"ABSTRACT Objectives: The Syrian Civil War forced millions into asylum in neighbouring countries. Refugees/asylum seekers have elevated risk for psychopathology with the most important being post-traumatic stress disorder (PTSD). Subjective experiences and symptoms of the hosting populations which have also experienced similar traumas have received relatively little attention up to now. We aimed to evaluate the effects of Syrian Civil War in terms of psychopathology, traumatic experiences and PTSD on Turkish primary school students living in Suruç which is on the border with Syria and hosts a large population of asylum seekers. Methods: Two randomly selected schools operating in the district were included in the study. Sociodemographic Data forms, Child Behaviour Checklist (CBCL), Children’s Post-traumatic Reaction Index (CPRI) were used for evaluations. Data were analysed with SPSS 23.0. P was set at 0.05 (two-tailed). Results: Most common traumatic experiences via parental report were witnessing explosions (26.9%), witnessing injuries of extended family/relatives (21.8%) and witnessing deaths of acquaintances (17.9%). Lifetime traumatic events and lifetime self-injurious behaviour in children via parental report were 26.9% and 19.9%; respectively. Of 156 students (53.2% male) with a mean age of 8.8 years (S.D. = 1.3), 13.5% obtained externalizing scores, 11.0% obtained internalizing scores and 13.5% obtained total scores in the clinical range of CBCL. 98.7% reported PTSD symptoms in moderate and above severity in CPRI. Most common traumatic experiences reported by children included hearing explosions/gunshots (17.3%), damage to residences (17.3%), and witnessing deaths of extended family/ acquaintances (12.8%). Female gender (p = .00), witnessing loss of family members/acquaintances in Syrian Civil War (p = .01) and clinically significant PTSD symptoms in CPRI. Conclusion: Children in communities hosting Syrian refugees/asylum seekers may also have elevated symptoms of PTSD and female gender may be a risk factor for those symptoms.","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"1 1","pages":"811 - 816"},"PeriodicalIF":0.7,"publicationDate":"2019-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91352156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Adolescent mental health, attachment characteristics, and unexplained chest pain: a case–control study 青少年心理健康、依恋特征和不明原因胸痛:一项病例对照研究
IF 0.7 4区 医学 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2019-10-02 DOI: 10.1080/24750573.2018.1454374
N. Bolat, K. Eliaçık, M. Yavuz, A. Kanık, Hilal Mertek, B. Guven, B. Dogrusoz, A. R. Bakiler
ABSTRACT OBJECTIVES: Psychological factors may be the underlying causes in unexplained chest pain (UCP). Chest pain symptom may influence the emotional status and peer relationships of the children and adolescents negatively. However, the number of studies focussing on the aetiology and consequences of the adolescent UCP are still limited. The aim of this study is to investigate the relationships among psychological problems, attachment characteristics, and the UCP in a group of adolescents. METHODS: Seventy-three adolescents with UCP and seventy-one healthy adolescents were included in the study. The adolescents completed the short form of Inventory of Parent and Peer Attachment (s-IPPA), and Strengths and Difficulties Questionnaire (SDQ), while their parents completed the parental form of the SDQ. RESULTS: Contrary to expectations, there was no significant interaction between total parental attachment levels and UCP in the adolescents with UCP. There were significant correlations between the attachment problems and total difficulties score of SDQ. Binary logistic regression analysis revealed that higher emotional and conduct problems and lower pro-social characteristics predict the UCP in adolescents, significantly. CONCLUSIONS: The results suggested that emotional/behavioural problems and lower pro-social behaviour scores are associated with UCP. However, further studies are needed for better understanding about the relationships between the UCP and attachment quality.
目的:心理因素可能是不明原因胸痛(UCP)的潜在原因。胸痛症状对儿童青少年的情绪状态和同伴关系有负向影响。然而,关注青少年UCP的病因和后果的研究数量仍然有限。摘要本研究旨在探讨一群青少年的心理问题、依恋特征与自我价值取向之间的关系。方法:将73名青少年UCP患者和71名健康青少年纳入研究。青少年完成父母与同伴依恋问卷(s-IPPA)和优势与困难问卷(SDQ),父母完成SDQ父母问卷。结果:与预期相反,父母总依恋水平与有UCP的青少年的UCP之间没有显著的相互作用。依恋问题与SDQ总分存在显著相关。二元logistic回归分析显示,较高的情绪、行为问题和较低的亲社会特征对青少年UCP有显著的预测作用。结论:结果表明情绪/行为问题和较低的亲社会行为得分与UCP有关。但是,对于UCP与依恋质量之间的关系,还需要进一步的研究。
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引用次数: 5
Examination of attention and memory processes of workers exposed to solvent for a long time 长时间接触溶剂工人注意记忆过程的研究
IF 0.7 4区 医学 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2019-10-02 DOI: 10.1080/24750573.2018.1470215
Lütfiye Söğütlü, N. Alaca, L. Önen
ABSTRACT PURPOSE: This study was planned to assess the attention and memory-based performances of workers who used solvent as part of their job and therefore who had been exposed to this substance for a long time. METHOD: The participants of the study are 31 workers who were diagnosed with solvent exposure in the occupational diseases polyclinic of Istanbul Occupational Diseases Hospital and who were treated as inpatient treatment. These 31 participants were individuals who worked for at least 1 year in solvent use, and who did not have any physical, neurological, or psychiatric diseases prior to the study. Beside the aforementioned study group, 30 healthy volunteers also participated in the study as the control group. The verbal memory processes test (VMPT), cancellation test (CT) and Stroop test TBAG form (STP) were applied to all participants. FINDINGS: The data revealed no significant difference between the study and control groups in terms of their short-term memory scores based on the VMPT scores of the participants. However, long-term memory scores, learning achievement scores and the highest learning achievement scores of the study group were found to be significantly lower than the control group. Comparing the two groups on CT and its sub-sections, the scores of the study group were found to be significantly higher than the control group. These findings present that the study group needed more time to complete the mentioned test. It was also revealed that the study group particularly completed the fifth sub-section of STP, which focuses on selective attention, in significantly longer amount of time than the control group. CONCLUSION: Long-term solvent exposure affects attention and memory processes negatively.
摘要目的:本研究旨在评估长期接触溶剂的工人的注意力和记忆表现。方法:研究对象为伊斯坦布尔职业病医院职业病综合门诊诊断为溶剂暴露并住院治疗的31名工人。这31名参与者在溶剂使用方面至少工作了1年,并且在研究前没有任何身体、神经或精神疾病。除上述研究组外,还有30名健康志愿者作为对照组参与研究。所有被试均采用言语记忆过程测试(VMPT)、取消测试(CT)和Stroop TBAG表格测试(STP)。研究结果:数据显示,在基于参与者的VMPT分数的短期记忆得分方面,实验组和对照组之间没有显著差异。然而,实验组的长期记忆得分、学习成就得分和最高学习成就得分明显低于对照组。比较两组CT及其分段,发现研究组的得分明显高于对照组。这些发现表明,研究组需要更多的时间来完成上述测试。研究还发现,与对照组相比,研究组在完成STP的第5小节(重点是选择性注意)所花费的时间明显更长。结论:长期溶剂暴露对注意和记忆过程有负面影响。
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引用次数: 0
Adjunct ketamine treatment effects on treatment-resistant depressive symptoms in chronic treatment-resistant schizophrenia patients are short-term and disassociated from regional homogeneity changes in key brain regions – a pilot study 辅助氯胺酮治疗对慢性难治性精神分裂症患者难治性抑郁症状的影响是短期的,并且与关键脑区的区域同质性变化无关——一项初步研究
IF 0.7 4区 医学 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2019-10-02 DOI: 10.1080/24750573.2019.1699726
J. Ye, Xiaodong Lin, Deguo Jiang, Min Chen, Yanchi Zhang, H. Tian, Jie Li, C. Zhuo, Yanling Zhao
ABSTRACT BACKGROUND: To investigate the effects of adjunct ketamine treatment on depressive symptoms and brain activity in chronic treatment-resistant schizophrenia (CTRS) patients with treatment-resistant depressive (TRD) symptoms. METHODS: Calgary Depression Scale for Schizophrenia (CDSS), positive and negative syndrome scale (PANSS), and regional homogeneity (ReHo) results were compared before versus after ketamine treatment in 12 CTRS patients with TRD symptoms. RESULTS: From 7 days to 14 days after the first ketamine administration, CDSS and PANSS total scores were reduced by 63.8% and 12.9%, respectively. By day 21, ReHo values had increased in the main components of the default mode network (DMN) and bilateral orbitofrontal cortex (OFC) after family-wise error correction. ReHo alterations did not correlate with TRD symptom changes. TRD symptoms relapsed by the 21-day time point, while increased ReHo was sustained. No adverse secondary effects (ASEs) necessitating medical intervention occurred. CONCLUSIONS: Adjunct ketamine alleviation of TRD symptoms lasted only a week, whereas increased ReHo in DMN regions and the OFC in CTRS patients was maintained beyond 2 weeks, indicating that adjunct ketamine is not well-suited for CTRS patients with TRD symptoms and that effects on functional activity dissociate from effects on TRD symptoms. This small-sample pilot study provides clues for further research into therapy for TRD symptoms in CTRS patients.
摘要背景:探讨氯胺酮辅助治疗对慢性难治性精神分裂症(CTRS)伴难治性抑郁(TRD)患者抑郁症状及脑活动的影响。方法:比较12例伴有TRD症状的精神分裂症卡尔加里抑郁量表(CDSS)、阳性和阴性综合征量表(PANSS)以及区域均一性(ReHo)结果。结果:第一次给药后7 ~ 14 d, CDSS和PANSS总分分别下降63.8%和12.9%。到第21天,在家庭误差校正后,默认模式网络(DMN)和双侧眶额皮质(OFC)的主要成分的ReHo值增加。ReHo改变与TRD症状改变无关。TRD症状在21天时间点复发,而ReHo持续升高。没有发生需要医疗干预的不良继发性反应(ASEs)。结论:氯胺酮辅助治疗对TRD症状的缓解仅持续1周,而CTRS患者DMN区域ReHo升高和OFC维持超过2周,表明氯胺酮辅助治疗不适合TRD症状的CTRS患者,对功能活性的影响与对TRD症状的影响相分离。这项小样本的试点研究为进一步研究trs患者TRD症状的治疗提供了线索。
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引用次数: 4
Vitamin B12 and haemoglobin levels may be related with ADHD symptoms: a study in Turkish children with ADHD 维生素B12和血红蛋白水平可能与多动症症状有关:一项对土耳其多动症儿童的研究
IF 0.7 4区 医学 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2019-10-02 DOI: 10.1080/24750573.2018.1459005
D. Unal, Fahri Çelebi, Hacer Neslihan Bildik, A. Koyuncu, S. Karahan
ABSTRACT OBJECTIVE: In this study, we evaluated vitamin B12 and iron parameters in Turkish children with ADHD in order to examine the relationship between ADHD symptoms and these parameters. METHODS: Drug-naive 100 ADHD patients, aged between 6 and 12 years old, were included in the study. None of them had acute or chronic diseases. All patients were assessed by using the Schedule for Affective Disorders and Schizophrenia for School Age Children – Present and Lifetime Version (K-SADS-PL). Conners Parent Rating Scale (CPRS) was used for screening ADHD symptoms and symptom severity. Blood samples were evaluated for ferritin, haemoglobin, MCV, RDW, and vitamin B12 parameters. RESULTS: We indicated an inverse relationship between haemoglobin levels and learning, anxiety subscale scores of CPRS. Also, vitamin B12 and psychosomatic subscale scores were found negatively related whereas the relationship was in the opposite direction for ferritin. Vitamin B12 level was negatively correlated with learning problems and psychosomatic subscales of CTRS in the combined subtype of ADHD. CONCLUSION: Vitamin B12 and iron support may be useful in treatment of childhood ADHD, especially for learning problems, besides medication.
摘要目的:在本研究中,我们评估了土耳其ADHD儿童的维生素B12和铁参数,以研究ADHD症状与这些参数之间的关系。方法:研究对象为100例6 ~ 12岁未接受药物治疗的ADHD患者。他们都没有急性或慢性疾病。所有患者均采用学龄儿童情感障碍和精神分裂症量表-现在和终生版(K-SADS-PL)进行评估。采用Conners父母评定量表(CPRS)筛选ADHD症状和症状严重程度。血液样本评估铁蛋白、血红蛋白、MCV、RDW和维生素B12参数。结果:我们发现血红蛋白水平与CPRS的学习、焦虑亚量表得分呈反比关系。此外,维生素B12和心身亚量表得分呈负相关,而铁蛋白则相反。维生素B12水平与ADHD合并亚型的学习问题和CTRS心身量表呈负相关。结论:除了药物治疗外,维生素B12和铁支持可能对治疗儿童多动症有用,特别是对学习问题。
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引用次数: 8
Efficacy and acceptability of three prolactin-sparing antipsychotics in patient with schizophrenia: a network meta-analysis 三种节省催乳素的抗精神病药物对精神分裂症患者的疗效和可接受性:一项网络荟萃分析
IF 0.7 4区 医学 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2019-09-27 DOI: 10.1080/24750573.2019.1662629
Jianjie Huang, Min Chen, Ce Chen, Xiaodong Lin, Deguo Jiang, Yonghui Zhang, Lina Wang, C. Zhuo, H. Tian, C. Du
ABSTRACT Background: The present study aimed to systematically evaluate three prolactin-sparing antipsychotics for treating schizophrenia. Methods: We performed a meta-analysis of three prolactin-sparing antipsychotics in patients with schizophrenia. Endpoints of interest were the Positive and Negative Syndrome Scale (PANSS), Brief Psychiatric Rating Scale (BPRS), Clinical Global Impressions-Severity (CGI-S) and acceptability (all cause discontinuation). Results: A total of 12 trials (2,723 patients) and three drugs (aripiprazole, quetiapine, and ziprasidone) were included. On the PANSS scale, aripiprazole (mean difference [MD]: −6.98, 95% CrI: −12.35, −1.38) was statistically more effective than placebo. When assessed by BPRS, aripiprazole (MD: −9.01, 95% CrI: −15.81, −3.12), quetiapine (MD: −7.13, 95% CrI: −9.78, −4.29) and ziprasidone (MD: −4.97, 95% CrI: 9.96, −0.21) had greater efficacy, when compared to placebo. Regarding CGI-S, quetiapine (MD: −0.55, 95% CrI: −0.82, −0.25) was significantly superior to placebo. In terms of acceptability, aripiprazole (OR: 0.54, 95% CrI: 0.41, 0.73), quetiapine (OR: 0.49, 95% CrI: 0.36, 0.68) and ziprasidone (OR: 0.68, 95% CrI: 0.48, 0.96) were more acceptable than placebo. The benefit risk analysis revealed that quetiapine has the best efficacy and acceptability profile among the three prolactin-sparing antipsychotics. Conclusions: Quetiapine may offer an optimal benefit-risk balance when a prolactin-sparing antipsychotic is indicated.
背景:本研究旨在系统评价三种节省催乳素的抗精神病药物治疗精神分裂症。方法:我们对精神分裂症患者的三种节省催乳素的抗精神病药物进行了荟萃分析。研究终点为阳性和阴性症状量表(PANSS)、简短精神病学评定量表(BPRS)、临床总体印象-严重程度(CGI-S)和可接受性(全因停药)。结果:共纳入12项试验(2723例患者),纳入3种药物(阿立哌唑、喹硫平、齐拉西酮)。在PANSS量表上,阿立哌唑(mean difference [MD]:−6.98,95% CrI:−12.35,−1.38)比安慰剂更有效。当BPRS评估时,与安慰剂相比,阿立哌唑(MD: - 9.01, 95% CrI: - 15.81, - 3.12)、喹硫平(MD: - 7.13, 95% CrI: - 9.78, - 4.29)和齐拉西酮(MD: - 4.97, 95% CrI: 9.96, - 0.21)的疗效更好。关于CGI-S,喹硫平(MD: - 0.55, 95% CrI: - 0.82, - 0.25)显著优于安慰剂。在可接受性方面,阿立哌唑(OR: 0.54, 95% CrI: 0.41, 0.73)、喹硫平(OR: 0.49, 95% CrI: 0.36, 0.68)和齐拉西酮(OR: 0.68, 95% CrI: 0.48, 0.96)的可接受性优于安慰剂。获益风险分析显示,在3种保留催乳素的抗精神病药物中,喹硫平的疗效和可接受性最好。结论:当需要保留催乳素的抗精神病药物时,喹硫平可能提供最佳的利益-风险平衡。
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引用次数: 2
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Psychiatry and Clinical Psychopharmacology
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