Psychiatry and Clinical Psychopharmacology最新文献

{"title":"PDW and RDW are new parameters for bipolar episodes and unipolar depression","authors":"I. Gundogmus, A. Algul, Abdulkadir Karagöz, Murat Kıyançiçek","doi":"10.1080/24750573.2018.1468616","DOIUrl":"https://doi.org/10.1080/24750573.2018.1468616","url":null,"abstract":"ABSTRACT INTRODUCTION: Bipolar disorder (BD) and unipolar depression (UD) are complex and multifactorial mental disorders characterized by mood swings, disability, and impaired quality of life. In the present study, we researched the roles of inflammatory cells and their value as inflammation markers in BD and UD. OBJECTIVE: Sixty-nine manic, 60 euthymic, and 70 UD patients and 60 sex-matched healthy volunteers (control group) were retrospectively analysed. Platelet (PLT), platelet distribution width (PDW), and red cell distribution width (RDW) levels were measured in four groups. The aim of this study was to evaluate PLT, PDW, and RDW levels patient with UD and two different phases of BD: euthymic and manic. RESULTS: In our study, 199 patients and 60 controls were included. There were no differences between the patients and the healthy control group participants in terms of age and sex. The bipolar episodes and the UD patient group were statistically significantly different from the healthy controls in terms of PLT, PDW, and RDW. CONCLUSION: Our study is the first in the literature to compare blood PLT, PDW, and RDW levels in bipolar episodes, UD patients, and healthy control groups. We believe that the levels of PLT, PDW, and RDW can be used as novel markers of bipolar episodes and UD. More detailed and larger prospective clinical studies are required to confirm these findings.","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"47 1","pages":"520 - 526"},"PeriodicalIF":0.7,"publicationDate":"2019-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91182704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trichotillomania treated with n-acetylcysteine","authors":"Faruk Kılıç, S. Keleş","doi":"10.1080/24750573.2018.1472907","DOIUrl":"https://doi.org/10.1080/24750573.2018.1472907","url":null,"abstract":"ABSTRACT Trichotillomania (TTM) is a disorder characterized by repetitive hair pulling resulting in hair loss and it is usually difficult to treat with a chronic course of illness. Currently, the selective serotonin reuptake inhibitors (SSRIs) are the most frequently prescribed drugs for adults with TTM. Various studies and case reports give mixed results. Therefore, the treatment effectiveness of SSRIs remains uncertain. There is a growing interest regarding the use of glutamatergic agents in obsessive compulsive disorder and obsessive compulsive spectrum disorder. Here, we report an 18-year-old female patient with TTM, which successfully treated with glutamate modulator n-acetylcysteine.","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"56 1","pages":"544 - 546"},"PeriodicalIF":0.7,"publicationDate":"2019-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81429398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity and reliability study of the Turkish version of the tolerance for mental pain scale-10","authors":"M. Demirkol, L. Tamam, Z. Namlı, Özge Eriş Davul","doi":"10.1080/24750573.2019.1699309","DOIUrl":"https://doi.org/10.1080/24750573.2019.1699309","url":null,"abstract":"ABSTRACT OBJECTIVE: Psychological pain has been accepted as one of the most critical psychological risk factors underlying suicidal ideation and behaviour. Suicide is chosen as a way to get rid of intense, painful and unbearable psychological pain. Since the level of tolerance rather than the intensity of psychological pain was considered to be more predictive for suicide, we aimed to investigate the validity and reliability of the Turkish version of Tolerance for Mental Pain Scale-10 (TMPS-10). METHODS: A total of 121 patients diagnosed with depression in 62 of them had previous suicide attempts and 105 healthy controls who applied to the outpatient clinics of Çukurova University Faculty of Medicine Psychiatry Department were included in the study. Beck Depression Inventory (BDI), Beck Scale for Suicidal Ideation (BSIS), Beck Hopelessness Scale (BHS), Psychache Scale (PS) and TMPS-10 were applied to participants. RESULTS: In the internal consistency analysis, Cronbach’s alpha coefficient was 0.96 for enduring the pain, 0.96 for managing the pain, 0.98 for the whole scale, and item-total correlation coefficients were found to be between 0.87 and 0.93. The scale fit well to both the two-factor and single-factor structure in the confirmatory factor analysis. The multi-group confirmatory factor analysis showed that both the depressive patients and the control group interpreted the scale items in the same way. In convergent validity analysis, there was a negative, linear, high and statistically significant relationship between TMPS-10 scores and PS, BSIS, BDI and BHS scores (r = −0.935; −0.779; −0.890; −0.808; p < .0.001, respectively). In discriminant function analysis, TMPS-10 successfully differentiated the depressive group and the control group, as well as the depressive patients who did or did not attempt suicide (96.5%, 88.1%, respectively). CONCLUSION: The Turkish version of TMPS-10 is valid and reliable, and may be useful in research and clinical practices about suicide.","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"28 1","pages":"899 - 906"},"PeriodicalIF":0.7,"publicationDate":"2019-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84769420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinctive clinical correlates of hazardous drinking","authors":"Ok-Jin Jang, Seon-Cheol Park, Se-Hoon Kim, S. Huh, Ji-Hoon Kim","doi":"10.1080/24750573.2019.1672246","DOIUrl":"https://doi.org/10.1080/24750573.2019.1672246","url":null,"abstract":"ABSTRACT The present study was conducted to identify clinical correlates of hazardous drinking (HD). The data were derived from the Korean Research for Development of Alcohol Addiction Diagnosis and Assessment System. Variable measurement were personal characteristics, lifetime alcohol use history, Motivational Structure Questionnaire for alcoholics, Alcohol Outcome Expectancies Scale, and Alcohol Dependence Scale. Behavioural, psychiatric, and psychological factors were evaluated by responses to the Rosenberg Self Esteem Scale, Jung Self Rating Depression Scale, Barratt Impulsiveness Scale-11, State Traits Anxiety Inventory, and State Trait Anger Expression Inventory. The valid sample comprised 295 male drinkers, 89 subjects (30.2%) were classified as HD, and 209 (69.8%) were in the non-HD (NHD) group by NIAAA criteria. The results of binary logistic analysis showed that age at the first blackout, coping, and social motives for alcohol use, and non-planning impulsiveness increased the likelihood of HD net of each other’s effects, and the final model explained 29.6% (Negelkerke R2) of the variation in HD.","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"6 1","pages":"817 - 821"},"PeriodicalIF":0.7,"publicationDate":"2019-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78328411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between emotional functioning and biological rhythm disruptions in patients with schizophrenia","authors":"Ç. Şahbaz, A. Kurtulmuş","doi":"10.1080/24750573.2019.1682853","DOIUrl":"https://doi.org/10.1080/24750573.2019.1682853","url":null,"abstract":"ABSTRACT Objective: Dysregulation of biological rhythm is associated with reduced executive functioning and potentiating psychosis, which are essential for the Theory of Mind (ToM) among patients with schizophrenia. However, the association between cognitive dysfunction, emotional information and disruption of biological rhythm remains uncertain. Methods: Forty-one patients with schizophrenia and forty age, gender and smoking status-matched healthy controls were recruited into the study. The Wisconsin Card Sorting Test (WCST), The Stroop test, The Reading the Mind in the Eyes Test (RMET), The Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN) were used. Results: BRIAN total, sleep, activity and social scores were higher in patients with schizophrenia than healthy controls. Higher BRIAN score was correlated with lower RMET score; with higher PANSS total, positive and negative scores, and not correlated with executive functions. In the regression analysis, it was observed that gender and increased BRIAN score was independently associated with lower scores for RMET in a patient with schizophrenia. Conclusion: These results suggest that the disruption of biological rhythm might be associated with ToM in patients with schizophrenia. Future research should examine the relationship between biological rhythm and ToM to determine if any causal associations can be identified.","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"31 1","pages":"455 - 462"},"PeriodicalIF":0.7,"publicationDate":"2019-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79483210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antineuronal antibodies and 8-OHdG an indicator of cerebellar dysfunction in autism spectrum disorder: a case–control study","authors":"F. Kılıçaslan, Hamza Ayaydın, H. Çelik, M. Kutuk, H. Kandemir, I. Koyuncu, A. Kirmit","doi":"10.1080/24750573.2019.1674241","DOIUrl":"https://doi.org/10.1080/24750573.2019.1674241","url":null,"abstract":"ABSTRACT Objectives: Autism spectrum disorder (ASD) is a neurodevelopmental disorder, that starts in early childhood and presents with deficiencies in social-communicational domains along with restricted and repetitive behaviours/interests. While genetic factors are dominant in its pathogenesis, many factors, including neurological, environmental and immunological have been identified. Furtheremore, although cerebellar dysfunction in the etiology of autism has been shown in different studies, the possible causes of the dysfunction and the role of neuroinflammation among these causes have not been clarified yet. Anti-Yo, anti-Hu, anti-Ri and anti-Amphiphysin antibodies have been found to be associated with cerebellar degeneration. The aim of the present study was to compare anti-Yo, anti-Hu, anti-Ri and anti- Amphiphysin antibodies and 8-OHdG values in blood using the ELISA method between ASD patients and healthy children to demonstrate the role of neuroinflammation as a potential cause of cerebellar dysfunction and DNA damage and evaluate the relationship between Childhood Autism Rating Scale (CARS) scores in children diagnosed with ASD and these parameters. Methods: Thirty-five consecutive children between the ages of 3 and 12 referred to the Child and Adolescent Psychiatry Outpatient Clinic of Harran University Hospital and diagnosed with ASD according to the DSM-5 diagnostic criteria were included in the study. The children did not have any chronic physical disorders and were treatment naive. Thirty-three healthy children between the ages of 3 and 12 without any physical or psychiatric disorders were included as the healthy control group. For psychiatric evaluation, a sociodemographic form and to measure the severity of autism, CARS was used. In the study, anti-Yo, anti-Hu, anti-Ri and anti-Amphiphysin antibodies and 8-OHdG values in blood were investigated using the ELISA method. Results: Thirty-five cases with autism (62.9% males) and thirty-three healthy controls (72.7% males) were included in the present study (p = 0.385). The median age was 6.0 in the ASD group and 7.0 in the control group (p = 0.146). Among ASD patients, anti-Ri antibody positivity was detected, while no anti-Ri antibody positivity was found in the control group (p = 0.002). In the ASD group, the anti-Hu and 8-OHdG values were found to be significantly higher than those of the controls (p < 0.001, p = 0.001); no significant difference was found between the ASD and control groups with regard to the anti-Yo and anti-Amphiphysin values (p = 0.113, p = 0.275). Conclusions: The results of the present study suggest that antibodies against cerebellum may be present among children with ASD and DNA damage may occur due to oxidative stress.","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"37 1","pages":"840 - 846"},"PeriodicalIF":0.7,"publicationDate":"2019-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75643993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cyberbullying among a clinical adolescent sample in Turkey: effects of problematic smartphone use, psychiatric symptoms, and emotion regulation difficulties","authors":"Hesna Gül, S. Fırat, M. Sertçelik, A. Gül, Yusuf Gürel, B. Kılıç","doi":"10.1080/24750573.2018.1472923","DOIUrl":"https://doi.org/10.1080/24750573.2018.1472923","url":null,"abstract":"ABSTRACT BACKGROUND: Cyberbullying, has concerned professionals due to increased use of media over time and as predicted, this type of bullying is fairly common among adolescents. We aimed to define the prevalence of cyberbullying and cyber victimization, examine relationships between problematic smartphone (SP) use (PSU), psychiatric symptoms and emotion regulation difficulties in a clinical adolescent sample. Also, we aimed to predict risk factors of being an E-Victim and E-Bully. METHODS: One hundred and fifty adolescents have recruited the study. Demographic Information Form, Problematic Mobile Phone Usage Scale, Brief Symptom Inventory, Difficulties in Emotion Regulation Scale, E-Victimization–E-Bullying Scale were filled out by adolescents. RESULTS: Our results indicated that the prevalence of cybervictimization and cyberbullying were 62.6% and 53.3%, respectively. BEVEB (Both E-Victim and E-Bully) group adolescents were older than NVB (Non-Victim/Bully) groups. Access internet via own SP, PSU, problems in strategies and impulse control and were significantly higher and “lack of awareness” scores were significantly lower in BEVEB group than others. In addition, when compared with OEV (only E-Victims) group, BEVEB group had also higher hostility scores. Logistic regression analysis revealed that high scores of “lack of awareness” and higher E-bullying scores increase the risk of being an E-Victim; and higher scores of hostility and E-victimization and lower scores of “lack of awareness” (in other words being more aware of feelings) increase the risk of being an E-bully. CONCLUSIONS: According to analyses, contrary to our expectations, PSU was important but not an independent predictor of being an E-Victim/E-Bully. Our results also demonstrated an interesting finding: lack of awareness is a risk factor for being an E-victim. We interpreted this result as could not be aware of feelings increase the victimization risk. On the other hand, E-Bullies have higher hostility and victimization while having lower “lack of awareness” scores. It could be speculated that, re-victimization and being aware of hostility feelings could increase the cyberbullying among adolescents. In addition being an E-Bully could be a consequence of being an E-victim and increasing hostility and awareness over time. These results should be re-examined in larger clinical samples.","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"1 1","pages":"547 - 557"},"PeriodicalIF":0.7,"publicationDate":"2019-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81552451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Birth order and reproductive stoppage in families of children with autism spectrum disorder","authors":"Ç. Uğur, A. Tonyali, Z. Goker, O. Uneri","doi":"10.1080/24750573.2018.1457489","DOIUrl":"https://doi.org/10.1080/24750573.2018.1457489","url":null,"abstract":"ABSTRACT OBJECTIVES: The objective of the study was to evaluate the birth order of children with Autism Spectrum Disorder (ASD) and ways of delivery at birth, together with the phenomenon of reproductive stoppage and the number of siblings in the case families (families of children with ASD in the study). METHODS: One hundred and ninety-six subjects with ASD and 54 healthy children were included into the study. Demographics were collected. Autism Behaviour Checklist (ABC), Aberrant Behaviour Checklist (AbBC), and Childhood Autism Rating Scale (CARS) were administered. Depending on the type of data and on the objective of the assessment, Mann–Whitney U-test, chi-square test, and Spearman tests were used for statistical analysis. A p-value smaller than .05 was considered to be statistically significant. RESULTS: In the study group consisting of children with ASD, the rate of being the first-born child was determined to be more frequent, significantly, compared to the rate in the control group (p = .001). It was also found that 86.7% (n = 170) of the children in the ASD group had at least one sibling compared to the rate of 81.5% (n = 44) for their counterparts in the control group. CONCLUSIONS: Our study compared ASD group to controls in terms of birth order, demonstrating a significant difference for being the first-born child in the ASD group. Birth order can be considered to be one of the several environmental factors that will help in understanding ASD, in which environmental factors can be the cause of phenotypic complexity. For all that, in our study, it was observed that having a child with autism in the Turkish sample did not affect the decision for the next pregnancy.","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"69 3 1","pages":"509 - 514"},"PeriodicalIF":0.7,"publicationDate":"2019-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89117782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early effects of selective serotonin reuptake inhibitors (SSRIs) on cornea and lens density in patients with depression","authors":"Yalçın Karaküçük, A. Beyoğlu, Ayşegül Çömez, F. Orhan, Merve Demir","doi":"10.1080/24750573.2019.1673944","DOIUrl":"https://doi.org/10.1080/24750573.2019.1673944","url":null,"abstract":"ABSTRACT PURPOSE: To investigate the effects of SSRIs on cornea and lens density, intraocular pressure (IOP) and anterior chamber parameters, including anterior chamber volume (ACV), anterior chamber depth (ACD), corneal volume (CV) and central corneal thickness (CCT), in patients with depression during a three-month follow-up period. METHOD: In this prospective study, 31 total patients, who were prescribed SSRIs for depression, were recruited. Sertraline, 50 mg/daily, was given to ten patients; 11 received Escitalopram, 10 mg/daily; and ten were treated with Fluoxetine, 20 mg/daily. The parameters recorded were corneal density (CD), lens density (LD), IOP, ACV, ACD, CV and CCT at the start of treatment, as well as at one-week, one-month, and three-month follow-ups. RESULTS: The study revealed that there was no risk of cataract development from three months of SSRI intake. Significant decrease in ACD was recorded at the one-week follow up; however, after three months, this decrease was insignificant compared to the baseline. ACV, CV, CCT, CD and LD showed no significant alterations in any of the follow up examinations over the three-month period. IOP, however, significantly fell (a P value of 0.004). CONCLUSION: In this study, SSRI use does not seem to be associated with an increased risk of cataract or glaucoma or with changes in CD and LD. Long-term follow-up is necessary to determine the actual risk of cataract or glaucoma with SSRI intake.","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"11 1","pages":"387 - 393"},"PeriodicalIF":0.7,"publicationDate":"2019-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81631854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The psychometric properties of the Generalized Anxiety Disorder scale (GAD-7) among Korean university students","authors":"Boram Lee, Yang-Eun Kim","doi":"10.1080/24750573.2019.1691320","DOIUrl":"https://doi.org/10.1080/24750573.2019.1691320","url":null,"abstract":"ABSTRACT OBJECTIVE: The seven-item Generalized Anxiety Disorder scale (GAD-7) is a practical self-report measure that screens for the severity of Generalized Anxiety Disorder in primary care. Previous studies have shown that the GAD-7 is theoretically sound, but the results regarding its psychometric properties have been somewhat inconsistent with both adult and student samples. Despite these findings, the psychometric properties of the GAD-7 have remained untested among Korean university students, for whom the identification of efficient measures of these constructs is especially important. To determine the psychometric properties of the GAD-7, the present study examined the internal consistency, convergent validity, and underlying factor structure of the GAD-7 with a sample of Korean university students. METHODS: The sample consisted of 582 students attending a four-year university in South Korea. All participants completed the Korean version of the GAD-7, the Depression Anxiety, and Stress Scale–21 (DASS-21), and the Patient Health Questionnaire (PHQ-9). The factor structure of the GAD-7 was assessed by exploratory factor analysis (EFA) and confirmatory factor analysis (CFA), and its convergent validity was determined by investigating its correlations with the DASS-21 and PHQ-9. RESULTS: CFA procedures confirmed that a modified one-factor model was an acceptable solution. The internal consistency of the scale was excellent. The GAD-7 showed a moderate to strong correlation with the three subscales of the DASS-21 and with the PHQ-9, confirming convergent validity. CONCLUSIONS: The findings indicate that the modified GAD-7 is a reliable and valid instrument for assessing generalized anxiety symptoms in university students. Its use for research and health care practice is warranted.","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"38 1","pages":"864 - 871"},"PeriodicalIF":0.7,"publicationDate":"2019-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82194592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}