Psychiatry and Clinical Psychopharmacology最新文献

Background: Major depressive disorder is the leading cause of mental health-related burden globally and up to one-third of major depressive disorder patients never achieve remission. Transcranial Direct Current Stimulation is a non-invasive intervention used to treat individuals diagnosed with major depressive disorder and bipolar disorder. Since the last transcranial direct current stimulation review specifically focusing on cognitive symptoms in major depressive disorder, twice as many papers have been published.

Methods: A systematic review was conducted with 5 electronic databases from database inception until March 21, 2022. Randomized controlled trials with at least 1 arm evaluating transcranial direct current stimulation in adults (diagnosed with major depressive disorder or bipolar disorder using the Diagnostic and Statistical Manual of Mental Disorders or International Classification of Diseases criteria) aged 18 or older were included. Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were adopted.

Results: : A total of 972 participants were included across 14 studies (60.5% female; mean age of 47.0 years [SD = 16.8]). Nine studies focused on participants with major depressive disorder and all studies used the Diagnostic and Statistical Manual of Mental Disorders to diagnose the participants. Seven out of the 14 studies showed significant improvements in at least 1 cognitive outcome measure in the active transcranial direct current stimulation group compared to the sham group. Several cognitive measures were used across studies, and 12 of the 14 studies reported mild-to-moderate side effects from treatment.

Conclusion: : Current transcranial direct current stimulation literature has shown limited evidence for the treatment of cognitive impairments in major depressive disorder and bipolar disorder. Future research that applies machine learning algorithms may enable us to distinguish responders from non-responders, increasing clinical benefits of transcranial direct current stimulation.

Background: Our study aimed to examine the possible risk of ventricular arrhythmia and sudden cardiac death by calculating the electrocardiographic changes and indicators of ventricular repolarization during and after alcohol withdrawal.

Methods: One hundred participants who were identified with alcohol withdrawal and who met the inclusion criteria were included in the study. Data were collected between July 2020 and August 2020. The distance interval between Q and T waves, corrected distance interval between Q and T waves, T peak/distance interval between Q and T waves, and T peak/corrected distance interval between Q and T waves interval ratios ratios were measured in 12-lead electrocardiographic measurements during the withdrawal period and after withdrawal symptoms subsided in patients with a Clinical Institute Withdrawal Assessment of Alcohol Scale, Revised score >7 and a Framingham heart risk score <10%.

Results: There was a significant difference between the patient's heart rate, distance interval between Q and T waves, corrected distance interval between Q and T waves interval, and T peak/distance interval between Q and T waves values during withdrawal (input) and after alcohol withdrawal (output) (P < .05). The mean corrected distance interval between Q and T waves interval input value (433.63 ± 17.79) is significantly different and higher than the output value of the mean corrected distance interval between Q and T waves (420.67 ± 13.78) (P < .05). Similarly, the mean T peak input value (81.36 ± 5.90) is significantly different and higher than the mean T peak output value (79.94 ± 5.39) (P < .05) and the mean T peak/input value of the distance interval between Q and T waves (0.222 ± 0.00) than the mean T peak / output value of the distance interval between Q and T waves (0.214 ± 0.00) (P < .001).

Conclusion: These consequences suggest the risk for an accelerated hazard of ventricular arrhythmias in participants with alcohol withdrawal. Significantly, considering the improvement of the electrocardiographic changes of the patients after terminating alcohol intake, a possible cardiac arrhythmia may be more common during this period. Close monitoring of electrocardiograms and timely withdrawal treatment can prevent life-threatening arrhythmias in alcohol withdrawal patients.

Background: This study aimed to evaluate oxidative damage by measuring erythrocytic reduced/oxidized glutathione as an intracellular thiol pool and serum thiol/disulfide homeostasis as an extracellular thiol pool in patients with opioid use disorder.

Methods: In this prospective cross-sectional study, 33 male patients diagnosed with opioid use disorder and 30 healthy male controls were included. Sociodemographic characteristics and psychometric analyzes were performed and addiction characteristics (duration and amount of heroin use, usage methods) were recorded. For the evaluation of oxidative balance, intracellular reduced-oxidized glutathione (reduced glutathione and oxidized glutathione), and extracellular thiol-disulfide (native thiol and disulfide) levels were measured.

Results: There was a decrease in reduced glutathione and native thiol levels and an increase in GSSG and SS levels. Similarly, while oxidized/reduced glutathione, oxidized/total glutathione%, and disulfide/native thiol % ratios increased, the ratio of reduced glutathione/total glutathione% and native thiol/total thiol% decreased. Moreover, a positive correlation was found between the level of both intracellular and extracellular oxidant molecules and the duration and amount of opioid use.

Conclusion: Impaired intracellular reduced glutathione/oxidized glutathione and extracellular disulfide/native thiol homeostasis were found in patients with opioid use disorder. The intracellular and extracellular oxidative stress may cause complications related to chronic opioid use.

Background: Monocytes secrete pro-inflammatory and pro-oxidant cytokines as part of inflammatory reactions. High-density lipoproteins have anti-inflammatory and antioxidant effects. This study investigated the potential use of the monocyte-to-high-density lipoprotein ratio in the follow-up of major depressive disorder.

Methods: The study group was composed of patients with newly diagnosed or preexisting major depressive disorder who applied to a psychiatric clinic and did not receive antidepressant treatment in the last 2 weeks. These patients were tested for the monocyte-to-high-density lipoprotein ratio in the psychiatric outpatient clinic both in the first interview and at their follow-up at 2 months. The control group, on the other hand, consisted of subjects who presented to the checkup clinic without any complaints.

Results: The study included a total of 98 individuals aged between 18 and 62 years, including 66 women and 32 men. The proportion of women in the study group was higher than that in the control group (P = .002). Patients in the study group had higher first high-density lipoprotein levels than healthy controls (P = .026). Beck's Depression Inventory scores of the study group decreased significantly from the first to the second interview (P < .001). There was no significant correlation between the percentage of change in Beck's Depression Inventory scores and the percentage of change in the monocyte-to-high-density lipoprotein ratio (P = .271).

Conclusion: The high-density lipoprotein levels in healthy controls were not higher than those in the group with major depressive disorder; monocyte levels did not differ between the groups and the monocyte-to-high-density lipoprotein ratio was not superior to Beck's Depression Inventory and could not be used in prognosis.

Background: Gut-blood and blood-brain barrier permeabilty (gut-brain axis) has been attracting increased attention in the etiology of neurodevelopmental disorders. In this study, we aimed to investigate serum levels of zonulin (a biomarker of intestinal permeability), claudin-5 (a biomarker of blood-brain barrier permeability), and interferon-gamma and interleukin-17A in children with specific learning disorder.

Methods: Forty-three children with DSM-5 diagnosis of specific learning disorder and 43 healthy children were included in this study. Serum levels of zonulin, claudin-5, interferon-gamma, and interleukin-17A were measured using commercial enzyme-linked immunosorbent assay kits.

Results: Serum zonulin and claudin-5 levels of the study group were significantly higher than the control group according to the multivariate analysis of covariance test while controlling for age, gender, and body mass index. However, serum interferon-gamma and interleukin-17A levels were not significantly different between the two groups. There was no correlation either between zonulin and interferon-gamma and interleukin-17A or claudin-5 and interferon-gamma and interleukin-17A.

Conclusion: Gut-blood and blood-brain barrier permeability may be disrupted in subjects with special learning disorder. Further research is needed to determine whether zonulin and claudin-5 may be biomarkers, and some dietary interventions or specific agents such as zonulin or claudin-5 inhibitors could be used in the management of neurodevelopmental disorders including special learning disorder.

Background: This research examined how the emotional temperaments of parents of children with attention deficit and hyperactivity disorder correlated with their perceptions of their children's social support from friends, teachers, and families. Additionally, the parents' emotional temperaments in terms of their association with children's low and high perceptions of family support were examined.

Methods: The study included 50 children with attention deficit and hyperactivity disorder, 40 neurotypical control subjects, and their parents. The Symptom Checklist-90-R was used to analyze the parents' psychopathology. The parents' affective temperaments were assessed using the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego-auto questionnaire version. The children's perceptions of their support from their families, peers, and teachers were evaluated using the Social Support Appraisal Scale.

Results: Mothers' depressive (r = -0.419, P = .002) and anxious temperaments (r = -0.338, P = .016) were inversely correlated with perceived social support from parents among children with attention deficit and hyperactivity disorder. Mothers' hyperthymic (r = 0.443, P = .001) and cyclothymic temperaments (r = 0.310, P = .029) and fathers' hyperthymic temperament (r = 0.371, P = .008) were positively correlated with perceived social support from parents. Regression analyses revealed that perceived social support from friends was predicted by paternal low cyclothymic and high anxious temperament. They also showed that inattention and mother's general psychopathology predicted perceived social support from family. Perceived social support from teacher was predicted by hyperactivity, maternal low cyclothymic temperament, and paternal high anxious temperament.

Conclusion: While parents' depressive and anxious temperaments were associated with low perceived social support from family, hyperthymic and cyclothymic temperaments were associated with increased perceived social support from the family among children with attention deficit and hyperactivity disorder.

Background: Gray matter alterations play a role in the panic disorder's pathophysiology origin. However, the current literature seemed inadequate to reach a consistent conclusion. Therefore, we conducted this gray matter meta-analysis on panic disorder.

Methods: A systematic review and a voxel-wise meta-analysis based on voxel-based morphometry were conducted for the gray matter studies in patients with panic disorder. The Seed-based d Mapping toolbox was applied for the voxel-wise meta-analysis. Fourteen gray matter studies (954 subjects) were enrolled in the current meta-analysis. The subgroup analysis of typical-onset versus late-onset patients was also performed. At last, the clinical severity was meta-regressed with gray matter alterations.

Results: Significant gray matter alterations were found in the left para-cingulate gyrus and the right amygdala of panic disorder patients. The subgroup analysis of typical-onset panic disorder patients showed a similar pattern. However, gray matter alterations were demonstrated in the bilateral opercular cortex of late-onset panic disorder patients. A significant association between the clinical severity and the gray matter alterations was found in the fronto-cingulate regions of panic disorder patients.

Conclusion: Gray matter alterations might represent a significant pillar of panic disorder's neurobiology, especially for the amygdala, cingulate, and frontal regions. Future gray matter studies in panic disorder should be needed to reconfirm this pattern of gray matter alterations.

Following the discovery of chlorpromazine's effectiveness as a treatment for schizophrenia in the 1950s, a gradual shift away from psychotherapeutic and toward biological methods of investigation has ensued. Nevertheless, psychological approaches to schizophrenia have a long history and continue to represent an important component of schizophrenia treatment. In the past 2 decades, there has been renewed interest in psychotherapy for schizophrenia among some clinicians and researchers. This article examines the current evidence for both psychodynamic and nonpsychodynamic (cognitive-behavioral, cognitive enhancement, and psychoeducational) therapies for schizophrenic illness. There is evidence to support the use of both types of therapies though these orientations generally differ in their views on the role of psychological factors in the etiology of schizophrenia. It is argued that a pluralistic or biopsychosocial model of schizophrenia is necessary to account for the complexity of the disease and to provide the most effective treatment.

Background: The aim of this study is to investigate the validity and reliability of the Turkish version of the Attitudes Toward Motherhood Scale. Attitudes Toward Motherhood Scale was developed by Sockol et al to evaluate cognitive distortions and attitudes toward motherhood during pregnancy and the postpartum period.

Methods: The sample of this study consisted of 223 pregnant women and 138 postpartum women. A Sociodemographic Data Form, the Edinburgh Postnatal Depression Scale, and Attitudes Toward Motherhood Scale were used to collect data from the participants.

Results: Cronbach's alpha coefficient for internal consistency was 0.868 for the entire sample, 0.877 during pregnancy, and 0.828 for the postpartum period. Factor analysis revealed that the 3-factor structure explained 68.93% of the variance. Pearson's correlation coefficient was calculated as 0.901 for the test-retest correlation analysis after 3 weeks (P < .001). There was a positive correlation between Attitudes Toward Motherhood Scale and Edinburgh Postnatal Depression Scale.

Conclusion: The results of this study revealed that the validity and reliability of the Turkish version of the Attitudes Toward Motherhood Scale were satisfactory.