Pub Date : 2019-09-13DOI: 10.1080/24750573.2019.1663582
H. Karatepe, K. F. Yavuz
ABSTRACT OBJECTIVES: Mindfulness is the awareness that emerges through paying attention on purpose, in the present moment, and nonjudgementally to the unfolding of experience moment to moment. Mindfulness-based interventions are frequently used in clinical situations and in establishing psychological well-being in a non-clinical sample as psychological techniques. Therefore, many mindfulness measures have been developed for use in clinical settings and for research purposes. Freiburg Mindfulness Inventory (FMI) is a self-report questionnaire that was developed to measure the trait mindfulness. In this study, we aimed to examine the validity, reliability, and factor structure of the FMI in a Turkish sample. METHODS: Participants were mostly college students (113 female, 93 male) and civil servants. Sociodemographic information, the Turkish version of the FMI, Acceptance and Action Questionnaire-II (AAQ-II), Five Facets Mindfulness Questionnaire (FFMQ) – All statistical analyses were performed by using SPSS version 20 and AMOS 23 version. RESULTS: The Cronbach’s alpha coefficient for the scale was 0.823, Guttman’s split-half reliability coefficient was 0.828, and test–retest reliability coefficient was 0.895. A positive and statistically significant correlation was found between the Turkish FMI and FFMQ (r = 0.566, p = .000). We found negative and statistically significant results between FMI and AAQ-II scores (r = −0.519 p = .000). We found strong statistical fit indices that can be acceptable for one-factor solution confirmatory factor analysis. CONCLUSIONS: The Turkish version of the FMI has satisfactory convergent and divergent validity, good internal and test–retest reliability with one-factor structure to use in a Turkish sample. We hope that Turkish form of FMI, which is known to be effective in assessing the mindfulness especially in a population that is familiar with the mindfulness practices, will be a useful alternative instrument for Turkish clinicians and researchers.
目的:正念是一种意识，它通过有意识地、在当下时刻、不加判断地关注当下体验的展开而产生。以正念为基础的干预经常用于临床情况，并作为心理学技术在非临床样本中建立心理健康。因此，许多正念测量已被开发用于临床环境和研究目的。弗莱堡正念量表(FMI)是一种用于测量正念特质的自我报告问卷。在本研究中，我们旨在检验土耳其样本中FMI的效度、信度和因素结构。方法:调查对象主要为大学生(女113人，男93人)和公务员。社会人口统计信息，土耳其版FMI，接受和行动问卷- ii (AAQ-II)，五方面正念问卷(FFMQ) -所有统计分析均使用SPSS 20版和AMOS 23版进行。结果:量表的Cronbach 's alpha系数为0.823,Guttman 's split-half信度系数为0.828，重测信度系数为0.895。土耳其FMI与FFMQ呈正相关且有统计学意义(r = 0.566, p = .000)。我们发现FMI和AAQ-II评分之间呈负相关且有统计学意义(r = - 0.519 p = .000)。我们发现强统计拟合指标，可以接受的单因素解决验证性因素分析。结论:土耳其版FMI具有令人满意的收敛效度和发散效度，具有良好的内部信度和重测信度，单因素结构适用于土耳其样本。我们希望土耳其形式的FMI，已知在评估正念方面是有效的，特别是在熟悉正念练习的人群中，将成为土耳其临床医生和研究人员的有用替代工具。
{"title":"Reliability, validity, and factorial structure of the Turkish version of the Freiburg Mindfulness Inventory (Turkish FMI)","authors":"H. Karatepe, K. F. Yavuz","doi":"10.1080/24750573.2019.1663582","DOIUrl":"https://doi.org/10.1080/24750573.2019.1663582","url":null,"abstract":"ABSTRACT OBJECTIVES: Mindfulness is the awareness that emerges through paying attention on purpose, in the present moment, and nonjudgementally to the unfolding of experience moment to moment. Mindfulness-based interventions are frequently used in clinical situations and in establishing psychological well-being in a non-clinical sample as psychological techniques. Therefore, many mindfulness measures have been developed for use in clinical settings and for research purposes. Freiburg Mindfulness Inventory (FMI) is a self-report questionnaire that was developed to measure the trait mindfulness. In this study, we aimed to examine the validity, reliability, and factor structure of the FMI in a Turkish sample. METHODS: Participants were mostly college students (113 female, 93 male) and civil servants. Sociodemographic information, the Turkish version of the FMI, Acceptance and Action Questionnaire-II (AAQ-II), Five Facets Mindfulness Questionnaire (FFMQ) – All statistical analyses were performed by using SPSS version 20 and AMOS 23 version. RESULTS: The Cronbach’s alpha coefficient for the scale was 0.823, Guttman’s split-half reliability coefficient was 0.828, and test–retest reliability coefficient was 0.895. A positive and statistically significant correlation was found between the Turkish FMI and FFMQ (r = 0.566, p = .000). We found negative and statistically significant results between FMI and AAQ-II scores (r = −0.519 p = .000). We found strong statistical fit indices that can be acceptable for one-factor solution confirmatory factor analysis. CONCLUSIONS: The Turkish version of the FMI has satisfactory convergent and divergent validity, good internal and test–retest reliability with one-factor structure to use in a Turkish sample. We hope that Turkish form of FMI, which is known to be effective in assessing the mindfulness especially in a population that is familiar with the mindfulness practices, will be a useful alternative instrument for Turkish clinicians and researchers.","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"17 1","pages":"472 - 478"},"PeriodicalIF":0.7,"publicationDate":"2019-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89432989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-31DOI: 10.1080/24750573.2019.1653134
Meltem Çınar, Pelin Kutlutürk, İ. Ertek, B. Coşar
ABSTRACT OBJECTIVE: Delusional parasitosis (DP), also known as Ekbom’s Syndrome, is a rare, generally monosymptomatic disorder that characterizes with the fixed belief of being infected by parasites without any evidence of medical or microbiological proof. These patients are examined in dermatology and infection clinics with symptoms and signs of pruritus, skin and subcutaneous scars secondary to itching. Primary DP is diagnosed when no etiological factor is detected while secondary DP arises from underlying physical or mental disorder. Formerly, pimozide was the commonly preferred choice of treatment with cases of DP. However, there is growing evidence that second-generation antipsychotics and antidepressants can be used in the treatment of DP. In this study, the usage of aripiprazole in the treatment of DP cases is presented. METHODS: 8 patients with the diagnosis of primary DP were evaluated in terms of demographic data, clinical variables and responses to treatment. A psychiatric diagnosis was made based on a clinical interview performed using Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I) SCID-I. The patients were followed for six months. Three patients were female, five patients were male. The average age of the patients was 57.5. Four patients had essential hypertension as comorbidity. The duration of the symptoms ranged from 6 to 48 months with an average of 24.75 months. All of our 8 cases were consulted by the dermatology department. The patients were performed Hamilton Depression Scale (HDS) and Mini-Mental Status Examination (MMSE). Eight patients were treated with aripiprazole 10 or 15 mg/day, and no dose alteration was made. RESULTS: From the patients who were treated with aripiprazole, seven (87.5%) patients had complete remission after three months, eight (100%) patients achieved complete remission after six months. DISCUSSION: The earliest drug choice for patients with DP was pimozide, but because of the extrapyramidal side effects and cardiac side effects like QTc prolongation, second-generation antipsychotics are being investigated for treatment. Various researches are available related to the usage of second-generation antipsychotics like risperidone, olanzapine, paliperidone, ziprasidone, quetiapine, and aripiprazole in the cases with DP. This study shows that aripiprazole can be a successful treatment choice for DP, but further studies are needed for this topic.
{"title":"Aripiprazole as a treatment option for delusional parasitosis: case series of 8 patients","authors":"Meltem Çınar, Pelin Kutlutürk, İ. Ertek, B. Coşar","doi":"10.1080/24750573.2019.1653134","DOIUrl":"https://doi.org/10.1080/24750573.2019.1653134","url":null,"abstract":"ABSTRACT OBJECTIVE: Delusional parasitosis (DP), also known as Ekbom’s Syndrome, is a rare, generally monosymptomatic disorder that characterizes with the fixed belief of being infected by parasites without any evidence of medical or microbiological proof. These patients are examined in dermatology and infection clinics with symptoms and signs of pruritus, skin and subcutaneous scars secondary to itching. Primary DP is diagnosed when no etiological factor is detected while secondary DP arises from underlying physical or mental disorder. Formerly, pimozide was the commonly preferred choice of treatment with cases of DP. However, there is growing evidence that second-generation antipsychotics and antidepressants can be used in the treatment of DP. In this study, the usage of aripiprazole in the treatment of DP cases is presented. METHODS: 8 patients with the diagnosis of primary DP were evaluated in terms of demographic data, clinical variables and responses to treatment. A psychiatric diagnosis was made based on a clinical interview performed using Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I) SCID-I. The patients were followed for six months. Three patients were female, five patients were male. The average age of the patients was 57.5. Four patients had essential hypertension as comorbidity. The duration of the symptoms ranged from 6 to 48 months with an average of 24.75 months. All of our 8 cases were consulted by the dermatology department. The patients were performed Hamilton Depression Scale (HDS) and Mini-Mental Status Examination (MMSE). Eight patients were treated with aripiprazole 10 or 15 mg/day, and no dose alteration was made. RESULTS: From the patients who were treated with aripiprazole, seven (87.5%) patients had complete remission after three months, eight (100%) patients achieved complete remission after six months. DISCUSSION: The earliest drug choice for patients with DP was pimozide, but because of the extrapyramidal side effects and cardiac side effects like QTc prolongation, second-generation antipsychotics are being investigated for treatment. Various researches are available related to the usage of second-generation antipsychotics like risperidone, olanzapine, paliperidone, ziprasidone, quetiapine, and aripiprazole in the cases with DP. This study shows that aripiprazole can be a successful treatment choice for DP, but further studies are needed for this topic.","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"9 1","pages":"794 - 797"},"PeriodicalIF":0.7,"publicationDate":"2019-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82146366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-30DOI: 10.1080/24750573.2019.1645410
E. Akatay, Tuğba Yüksel, Nazan Ekinci, Bilge Didem Tunali, Selin Ayşe İpek Baş, Ö. İ. Doğan, Özalp Ekinci
It is defined as childhood onset or early onset schizophrenia when it starts at the age of 13. In this presentation, a male patient who was diagnosed with schizophrenia at age 10 was discussed. Case presentation: A 10-year-old male patient presented to our outpatient clinic with complaints of nervousness, aggression, introversion, and self-talk, which started about 9 months ago. The parents reported observed disorganized behaviour in the form of self-talk and laughter, nightly fears, repetitive conversations and gestures, trusting people, and wanting to kill them, putting his hand in his mouth and butt, going under the table all the time in class. The patient had aphonia, which started three days before he arrived in our outpatient clinic. No organic pathology was found in the neurological examination and his brain MRI exam was unremarkable. No psychiatric history in the family were reported. Parents reported that he started walking in 15 months, and he started speaking when he was 5–6 years old. In his psychiatric examination, distraction of the patient during the interview, incoherence, the blocks of thought, self-talk and laughter, and disorganized behaviour were remarkable. Patient was diagnosed with schizophrenia and olanzapine treatment was started and he was followed regularly. Our case is important in terms of starting at an early age, quick onset of symptoms, and poor functionality. Due to the facts that the age of our patient was young and his parents were not cooperating in the treatment, these affected the clinical prognosis negatively. Treatment guidelines for earlyonset schizophrenia are based on adult literature and clinical experience, and therefore further studies are needed in the child age group for effective treatment.
{"title":"11th International Congress on Psychopharmacology & 7th International Symposium on Child and Adolescent Psychopharmacology Case Reports Addendum","authors":"E. Akatay, Tuğba Yüksel, Nazan Ekinci, Bilge Didem Tunali, Selin Ayşe İpek Baş, Ö. İ. Doğan, Özalp Ekinci","doi":"10.1080/24750573.2019.1645410","DOIUrl":"https://doi.org/10.1080/24750573.2019.1645410","url":null,"abstract":"It is defined as childhood onset or early onset schizophrenia when it starts at the age of 13. In this presentation, a male patient who was diagnosed with schizophrenia at age 10 was discussed. Case presentation: A 10-year-old male patient presented to our outpatient clinic with complaints of nervousness, aggression, introversion, and self-talk, which started about 9 months ago. The parents reported observed disorganized behaviour in the form of self-talk and laughter, nightly fears, repetitive conversations and gestures, trusting people, and wanting to kill them, putting his hand in his mouth and butt, going under the table all the time in class. The patient had aphonia, which started three days before he arrived in our outpatient clinic. No organic pathology was found in the neurological examination and his brain MRI exam was unremarkable. No psychiatric history in the family were reported. Parents reported that he started walking in 15 months, and he started speaking when he was 5–6 years old. In his psychiatric examination, distraction of the patient during the interview, incoherence, the blocks of thought, self-talk and laughter, and disorganized behaviour were remarkable. Patient was diagnosed with schizophrenia and olanzapine treatment was started and he was followed regularly. Our case is important in terms of starting at an early age, quick onset of symptoms, and poor functionality. Due to the facts that the age of our patient was young and his parents were not cooperating in the treatment, these affected the clinical prognosis negatively. Treatment guidelines for earlyonset schizophrenia are based on adult literature and clinical experience, and therefore further studies are needed in the child age group for effective treatment.","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"26 1","pages":"447 - 453"},"PeriodicalIF":0.7,"publicationDate":"2019-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81283053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-16DOI: 10.1080/24750573.2019.1653149
Tugba Mutu Pek, E. Yazıcı, Derya Guzel, E. Kose, A. Yazıcı, Atila Erol
ABSTRACT Objective: The aim of this study was to investigate the relationship between oxytocin (OXT), vasopressin (AVP) and atrial natriuretic peptide (ANP) levels and cognitive functions in schzophrenia as well as to compare the findings to those in healthy controls. Method: Patients with chronic schizophrenia and (n=63) healthy controls (n=60) were evaluated with the Rey Auditory Verbal Learning Test (VLT), the Trail Making Test A-B (TMT), the Stroop Test, the Wechsler Memory Scale-Visual Production Subscale (WMS-V) and the Facial Emotion Recognition Tests. Blood samples were analysed by using ELISA. In the data analysis, the percentage distributions of the variables were obtained, the centrality and prevalence measures (mean, standard deviation) were calculated for the continuous variables, and the dependent and independent variables were evaluated using the chi-square test, the Student’s t-test, and the Pearson correlation test. High score variables were determined by principal component analysis. For comparisons between groups; MANOVA applied. Results: Serum OXT, AVP and ANP levels did not differ between the groups. In the healthy control group, subscales of the Stroop, WMS-V and TMT-B tests showed better scores and correlated with levels of OXT (p < .05). In the healthy controls, ANP levels and social cognition had a relationship with response times to happy facial expressions (p < .05). The correlations of OXT, AVP and ANP with the social and cognitive parameters were different between the control group and the schizophrenia group (p < .05). Conclusion: The different correlations in the healthy controls and schizophrenia group suggest deteriorations in the interactions and functions of hormones in patients and highlights the need for new investigations into different neurodegenerative illness samples.
{"title":"The relationship between oxytocin, vasopressin and atrial natriuretic peptide levels and cognitive functions in patients with schizophrenia","authors":"Tugba Mutu Pek, E. Yazıcı, Derya Guzel, E. Kose, A. Yazıcı, Atila Erol","doi":"10.1080/24750573.2019.1653149","DOIUrl":"https://doi.org/10.1080/24750573.2019.1653149","url":null,"abstract":"ABSTRACT Objective: The aim of this study was to investigate the relationship between oxytocin (OXT), vasopressin (AVP) and atrial natriuretic peptide (ANP) levels and cognitive functions in schzophrenia as well as to compare the findings to those in healthy controls. Method: Patients with chronic schizophrenia and (n=63) healthy controls (n=60) were evaluated with the Rey Auditory Verbal Learning Test (VLT), the Trail Making Test A-B (TMT), the Stroop Test, the Wechsler Memory Scale-Visual Production Subscale (WMS-V) and the Facial Emotion Recognition Tests. Blood samples were analysed by using ELISA. In the data analysis, the percentage distributions of the variables were obtained, the centrality and prevalence measures (mean, standard deviation) were calculated for the continuous variables, and the dependent and independent variables were evaluated using the chi-square test, the Student’s t-test, and the Pearson correlation test. High score variables were determined by principal component analysis. For comparisons between groups; MANOVA applied. Results: Serum OXT, AVP and ANP levels did not differ between the groups. In the healthy control group, subscales of the Stroop, WMS-V and TMT-B tests showed better scores and correlated with levels of OXT (p < .05). In the healthy controls, ANP levels and social cognition had a relationship with response times to happy facial expressions (p < .05). The correlations of OXT, AVP and ANP with the social and cognitive parameters were different between the control group and the schizophrenia group (p < .05). Conclusion: The different correlations in the healthy controls and schizophrenia group suggest deteriorations in the interactions and functions of hormones in patients and highlights the need for new investigations into different neurodegenerative illness samples.","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"324 1","pages":"798 - 810"},"PeriodicalIF":0.7,"publicationDate":"2019-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78408541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-13DOI: 10.1080/24750573.2019.1606883
N. Müller
Selected publications: Müller N and Schwarz MJ. (2007) The immunological basis of glutamatergic disturbance in schizophrenia: towards an integrated view. J Neural Transm (Suppl 72): 269-280. Müller N and Schwarz MJ. (2007) The immune-mediated alteration of serotonin and glutamate: towards an integrated view of depression. Mol Psychiatry 1-13. (2006) The cyclooxygenase-2 inhibitor celecoxib has therapeutic effects in major depression: results of a double-blind, randomized, placebo-controlled, add-on pilot study to reboxetine. Molecular Psychiatry 11: 680-684. (2002) Beneficial antipsychotic effects of celecoxib add-on therapy compared to risperidone alone in schizophrenia.
{"title":"11th International Congress on Psychopharmacology & 7th International Symposium on Child and Adolescent Psychopharmacology","authors":"N. Müller","doi":"10.1080/24750573.2019.1606883","DOIUrl":"https://doi.org/10.1080/24750573.2019.1606883","url":null,"abstract":"Selected publications: Müller N and Schwarz MJ. (2007) The immunological basis of glutamatergic disturbance in schizophrenia: towards an integrated view. J Neural Transm (Suppl 72): 269-280. Müller N and Schwarz MJ. (2007) The immune-mediated alteration of serotonin and glutamate: towards an integrated view of depression. Mol Psychiatry 1-13. (2006) The cyclooxygenase-2 inhibitor celecoxib has therapeutic effects in major depression: results of a double-blind, randomized, placebo-controlled, add-on pilot study to reboxetine. Molecular Psychiatry 11: 680-684. (2002) Beneficial antipsychotic effects of celecoxib add-on therapy compared to risperidone alone in schizophrenia.","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"26 1","pages":"311 - 446"},"PeriodicalIF":0.7,"publicationDate":"2019-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75515549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-13DOI: 10.1080/24750573.2019.1603432
M. E. Özen, Mehmet Hamdi Örüm
OBJECTIVE: The available evidence suggests that the main pathological processes underlying Bipolar Disorder and the potential harmful effects of mood episodes are closely related to changes in disorder activity and mood status. Although there are several studies on the existence of a relationship, the results are contradictory. Inflammatory changes occur in various episodes of Bipolar Disorder (BD) Type 1. These changes can be considered as peripheral symptoms of the disorder. In this study, we aimed to compare the inflammatory biomarkers in the BD patients in the manic, depressive and euthymic period with the healthy controls. METHODS: Interleukins (IL) and tumour necrosis factor (TNF) values were measured and compared in 78 healthy controls with 108 patients with BD. RESULTS: There was a statistically significant difference between the patient and control groups in terms of age (p = .040) and educational status (p = .002). There were no statistically significant differences between the BD subgroups with regard to clinical variables such as the age of onset (p = .862), duration of disease (p = .389) and the age of hospitalization (p = .092). In the subgroup of mania, the rate of psychiatric hospitalization was higher than depression or other subgroups (p = .047). When the blood values of peripheral biomarkers (IL-2, IL-4, IL-8, IL-10 and TNFα) were compared, there was no statistically significant difference between the values of the peripheral biomarkers of all BD patients and the control group. The levels of IL10 were higher in the control group than in the BD group, but not statistically significant. CONCLUSIONS: As a result, there was no statistically significant difference between the two groups when comparing serum concentrations of basic IL and TNF in the BD group and control group. There was no difference in the comparison among the patient groups. IL-2 and IL-4 and manic episodes of IL-2 in manic episode were not significant. Therefore, in order to clarify the relationship between inflammatory biomarkers in BD and its possible association with pharmacological treatments, biomarker measurements are required in larger patient samples and ideally at different mood stages and even at different times of the same attack.
{"title":"11th International Congress on Psychopharmacology & 7th International Symposium on Child and Adolescent Psychopharmacology","authors":"M. E. Özen, Mehmet Hamdi Örüm","doi":"10.1080/24750573.2019.1603432","DOIUrl":"https://doi.org/10.1080/24750573.2019.1603432","url":null,"abstract":"OBJECTIVE: The available evidence suggests that the main pathological processes underlying Bipolar Disorder and the potential harmful effects of mood episodes are closely related to changes in disorder activity and mood status. Although there are several studies on the existence of a relationship, the results are contradictory. Inflammatory changes occur in various episodes of Bipolar Disorder (BD) Type 1. These changes can be considered as peripheral symptoms of the disorder. In this study, we aimed to compare the inflammatory biomarkers in the BD patients in the manic, depressive and euthymic period with the healthy controls. METHODS: Interleukins (IL) and tumour necrosis factor (TNF) values were measured and compared in 78 healthy controls with 108 patients with BD. RESULTS: There was a statistically significant difference between the patient and control groups in terms of age (p = .040) and educational status (p = .002). There were no statistically significant differences between the BD subgroups with regard to clinical variables such as the age of onset (p = .862), duration of disease (p = .389) and the age of hospitalization (p = .092). In the subgroup of mania, the rate of psychiatric hospitalization was higher than depression or other subgroups (p = .047). When the blood values of peripheral biomarkers (IL-2, IL-4, IL-8, IL-10 and TNFα) were compared, there was no statistically significant difference between the values of the peripheral biomarkers of all BD patients and the control group. The levels of IL10 were higher in the control group than in the BD group, but not statistically significant. CONCLUSIONS: As a result, there was no statistically significant difference between the two groups when comparing serum concentrations of basic IL and TNF in the BD group and control group. There was no difference in the comparison among the patient groups. IL-2 and IL-4 and manic episodes of IL-2 in manic episode were not significant. Therefore, in order to clarify the relationship between inflammatory biomarkers in BD and its possible association with pharmacological treatments, biomarker measurements are required in larger patient samples and ideally at different mood stages and even at different times of the same attack.","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"47 1","pages":"113 - 128"},"PeriodicalIF":0.7,"publicationDate":"2019-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82365095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-13DOI: 10.1080/24750573.2019.1608692
B. Karakök, Baki Artık, Yusuf Karaer, V. Y. Kabak, Nilay Şahan, T. Çak, S. Uysal, E. Kültür
Objective: Attention-deficit hyperactivity disorder (ADHD) is the most common neurodevelopmental disorder in school-age children. It is accepted that sensory-motor and attention functions are closely associated and up to two thirds of children with ADHD suffer motor skill problems that adversely affect their social adaptation, peer relations, and academic skills. Atomoxetine (ATX) and methylphenidate (MPH) are preferentially used drugs for treatment. MPH is a central nervous system stimulant, whereas ATX is a non-stimulant selective norepinephrine reuptake inhibitor that is used to treat ADHD. The impact of ATX and MPH on attention and ADHD symptoms is well documented. However, the effects of MPH on motor skills are less studied and no data are currently available on the effects of atomoxetine on motor skills. The aim of this study is to investigate the effects of MPH and ATX on gross and fine motor skills in school-aged children with ADHD. Methods: Participants were 36 right-handed boys with ADHD (aged between 6 and 10 years, mean 7.88 years). The Kiddie Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version was used to confirm the diagnosis and rule out other comorbid psychiatric disorders. Gross and fine motor skills were assessed with the Bruininks–Oseretsky Test of Motor Proficiency, Second Edition (BOT-2). Twenty-five boys were treated with ATX and 11 with methylphenidate. BOT-2 was applied to both groups before and after 8–12 weeks of treatment. Results: There were no statistically significant differences between the ATX and the MPH groups for all subtests of BOT-2 preand post-medication. When both groups were compared in terms of preand post-treatment gross and fine motor skills, the scores for fine manual control of 12 (48%) children in ATX group increased but did not reach statistical significance. The scores for fine manual control of 5 (45%) children in MPH group increased but did not reach statistical significance. Surprisingly, statistically significant decrease was found in running speed and agility, strength, and body coordination scores in the ATX group, and statistically significant decrease was found in body coordination score in the MPH group. Conclusion: Motor coordination is important in daily life and poor motor skills have a negative impact on a child’s daily living and academic performance. Furthermore, this problem may persist into adulthood with an increase in problems associated with psychosocial adjustment. Our preliminary results revealed that although there was an increase of fine motor control scores after treatment in both groups, statistically significant difference was not found between before and after treatment. Significant decrease in speed and agility and strength scores may be due to reduced impulsivity. While few studies have revealed an improvement on standardized evaluation of attention and motor skills in children taking MPH, more research is needed to gain an understanding of t
{"title":"11th International Congress on Psychopharmacology & 7th International Symposium on Child and Adolescent Psychopharmacology","authors":"B. Karakök, Baki Artık, Yusuf Karaer, V. Y. Kabak, Nilay Şahan, T. Çak, S. Uysal, E. Kültür","doi":"10.1080/24750573.2019.1608692","DOIUrl":"https://doi.org/10.1080/24750573.2019.1608692","url":null,"abstract":"Objective: Attention-deficit hyperactivity disorder (ADHD) is the most common neurodevelopmental disorder in school-age children. It is accepted that sensory-motor and attention functions are closely associated and up to two thirds of children with ADHD suffer motor skill problems that adversely affect their social adaptation, peer relations, and academic skills. Atomoxetine (ATX) and methylphenidate (MPH) are preferentially used drugs for treatment. MPH is a central nervous system stimulant, whereas ATX is a non-stimulant selective norepinephrine reuptake inhibitor that is used to treat ADHD. The impact of ATX and MPH on attention and ADHD symptoms is well documented. However, the effects of MPH on motor skills are less studied and no data are currently available on the effects of atomoxetine on motor skills. The aim of this study is to investigate the effects of MPH and ATX on gross and fine motor skills in school-aged children with ADHD. Methods: Participants were 36 right-handed boys with ADHD (aged between 6 and 10 years, mean 7.88 years). The Kiddie Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version was used to confirm the diagnosis and rule out other comorbid psychiatric disorders. Gross and fine motor skills were assessed with the Bruininks–Oseretsky Test of Motor Proficiency, Second Edition (BOT-2). Twenty-five boys were treated with ATX and 11 with methylphenidate. BOT-2 was applied to both groups before and after 8–12 weeks of treatment. Results: There were no statistically significant differences between the ATX and the MPH groups for all subtests of BOT-2 preand post-medication. When both groups were compared in terms of preand post-treatment gross and fine motor skills, the scores for fine manual control of 12 (48%) children in ATX group increased but did not reach statistical significance. The scores for fine manual control of 5 (45%) children in MPH group increased but did not reach statistical significance. Surprisingly, statistically significant decrease was found in running speed and agility, strength, and body coordination scores in the ATX group, and statistically significant decrease was found in body coordination score in the MPH group. Conclusion: Motor coordination is important in daily life and poor motor skills have a negative impact on a child’s daily living and academic performance. Furthermore, this problem may persist into adulthood with an increase in problems associated with psychosocial adjustment. Our preliminary results revealed that although there was an increase of fine motor control scores after treatment in both groups, statistically significant difference was not found between before and after treatment. Significant decrease in speed and agility and strength scores may be due to reduced impulsivity. While few studies have revealed an improvement on standardized evaluation of attention and motor skills in children taking MPH, more research is needed to gain an understanding of t","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"60 1","pages":"264 - 310"},"PeriodicalIF":0.7,"publicationDate":"2019-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84885978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-13DOI: 10.1080/24750573.2019.1648733
Ado-Baba Ahmed, A. A. Zubairu, A. Ahmed, Fatima Lamido, Mayowa Niyi
s 1 Optical coherence tomography findings in autism spectrum disorder and healthy controls Mahmut Zabit Kara and Mehmet Hamdi Örüm 1 Blood levels of interleukin-1 beta, interleukin-6 and tumor necrosis factor-alpha and cognitive functions in patients with obsessive compulsive disorder Evrim Özkorumak Karagüzel, Filiz Civil Arslan, Demet Sağlam Aykut, Emel Uysal, Selim Demir, Mustafa Tat and Süleyman Caner Karahan 3 Relationship of self-mutilative behaviour with internet gaming disorder symptoms and emotion dysregulation among young adults Bilge Evren 5 Comparative evaluation of somatization and abnormal illness behaviors in fibromyalgia patients with diagnostic and statistical manual of mental disorders, fifth edition (DSM-5) and diagnostic criteria for psychosomatic research (DCPR) Gizem Kara, Filiz Civil Arslan, Evrim Özkorumak Karagüzel and Demet Sağlam Aykut 5 Obsessive-compulsive disorder, genetic issues and internal health issues Şaban Karayağız 6 Platelet count and platelet lymphocyte ratio in patients with psychosis Hasan Korkmaz, Sevda Korkmaz, Sema Baykara, Dilek Ulukan, Ayşe Merve Denk and Sevler Yıldız 7 Evaluation of the correlation between smoking and sex life in a non-clinical sample Sevda Korkmaz, Sema Baykara and Hasan Korkmaz 7 Comparison of patients with mild and severe fibromyalgia syndrome in terms of coping ways Sema Baykara 8 Neuropsychiatric and sociodemographic features of centenarian people who live in rize Tuğba Uyar and Neslihan Deniz 9 Evaluation of impulsivity and the relationship between affective symptoms and impulsivity in patients with epilepsy Selen Işık Ulusoy and Bahriye Horasanlı 9 The determination of vitamin D, vitamin B12 and folic acid levels of patient in pychiatry clinic Faruk Kiliç, Cemile Aksoy, Arif Demirdaş and Ümit Işik 10 Investıgatıon of psychopathology and related varıables In adolescents wıth conversıon dısorders Serhat Kala, Ender Atabay, Dilşad Foto Özdemir and Ferhunde Öktem 11 Optimization of therapeutic tactics in patients with opioid addiction Vasila Abdullaeva 11 Cultural dependence of attitude towards psychotherapeutic treatment german compared to Turkish people in first and second generation Dilek Sahin 12 Evaluation of the clinical features of schizophrenia patients following psychosocial skills training in a community mental health center of a training and research hospital Esin Erdoğan and Dursun Hakan Delibaş 13 Sociodemographic and clinical characteristics of voluntary and involuntary psychiatric admissions in a foundation university hospital Buğra Çetin 13 The relationship between leptin receptor polymorphism and suicide in depressed adolescents Sadettin Burak Açıkel, Canan Eroğlu, Asiye Uğraş Dikmen and Ercan Kurar 14 The relationship between expressed emotion and treatment resistance in patients with major depression Fatih Baz, Erdoğdu Akça and Mesut Yıldız 15 Comparison of fetal and maternal attachment between peripartum anxiety disorder diagnosed and healthy women Buket Güngö
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Pub Date : 2019-08-13DOI: 10.1080/24750573.2019.1608065
E. Atabay, A. Arman
Atypical antipsychotics (SGA) are used as first choice but this group of drugs may cause relatively more metabolic problems. Diabetic ketoacidosis (DCA) known as an acute, life-threatening complication of diabetes, can be triggered by use of SGA. In this presentation, we present a 17year-old male patient who had DCA that thought to be triggered by olanzapine treatment. Case presentation: E. has been followed up and treated for about 6 years in child and adolescent psychiatry outpatient clinic. He had no history of smoking, alcohol or substance abuse in any period of his life. There was no history of psychiatric disease in the family. His aunt has a history of type 2 diabetes. The first time he consulted us was about 2 years agowith the complaint of irritability, harm to his family and sleep problems. In this interview, we learned that she had been treated with risperidone 2 mg/day but had no benefit. Mental status examination revealed any hypomanic, manic, psychotic symptoms and signs. Aripiprazole 5 mg/day treatment was arranged and he benefited from drug. Patient was admitted again after 2.5 months and family had complaints of “inability to sleep, fears, biting himself, talking to himself”. Avolition, dirtiness obsessions and cleaning compulsions, visual, auditory and auditory hallucinations were determined in the examination. Patient was referred to child neurology and psychiatric hospitalization was recommended. However family did not want hospitalization and no pathology was found in her neurological examination. Patient was planned to have olanzapine 5 mg, 2 times a day. Approximately 1.5 months later, the patient re-admitted to us, he was so irritable, anxious, unsleeping and suggested to continuation of olanzapine in morning 5 mg and evening 10 mg. In third week of treatment, patient was admitted to the emergency room with nausea, vomiting, abdominal pain and blurred consciousness. In the evaluation; blood glucose 434 mg/dl, urine glucose 3+, protein 2+, ketone 3+, pH 6.0; The blood gas pH was found to be 7.146 and it was accepted to the pediatric intensive care unit with diagnosis of diabetic ketoacidosis. Olanzapine treatment was discontinued and he was discharged with insulin therapy. The patient is still followed up with aripiprazole 15 mg/day treatment. How SGA lead to hyperglycemia remains unclear. Due to the weight gain effects of olanzapine, increasing peripheral and hepatic insulin resistance and stimulating X receptor are most known factors contributing to this effect. This mechanism does not seem possible to explain the rapid onset of diabetes. Some clinical trials with olanzapine have shown biphasic changes in insulin secretion in patients. Olanzapine acts on direct beta cells in the early period of treatment and that insulin secretion decreases significantly may accompany this metabolic condition. As in our patient, it is stated that this possibility increases in case of genetic predisposition. Particular attention should be
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Pub Date : 2019-08-13DOI: 10.1080/24750573.2019.1603000
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