Lenar I. Musin, Renat M. Akhmadullin, Karim R. Gizutdinov, Lilya Sh. Nigmatullina, Leonid V. Lopukhov, Anna N. Zaripova, Dinar D. Nigamatullin, Valerii V. Spiryagin, Huu Quynh Anh Le, Thi Nam Pham, My Uyen Dao, Hong Dung Lai, Hien Y Hoang
This study presents a short communication on exploring, for the first time, a simple approach for the selective and highly effective synthesis of tricaproin by synergistically combining silicon tripolyphosphate and phosphoric acid in the catalytic esterification of glycerol with caproic acid. Results reveal that within the initial hour of the synthesis, the conversion in the presence of the proposed mixture achieved an efficiency of 62.99 %, whereas this figure for individual catalysts only modestly stopped at 27.50 and 11.74 %, respectively. Furthermore, the inherent shortcomings in the tricaprion synthesis, such as catalyst deactivation, resinification of the reaction solution, and generation of numerous by-products, were successfully addressed. The structure of the resultant tricaproin and the possible absence of undesired by-products were confirmed by NMR, mass spectrometry, FT-IR, and TLC. The optimal conditions for the synthesis were also investigated. The study not only contributes a practical and selective synthetic approach for tricaproin but also paves the way for exploring novel avenues to enhance the efficiency of the catalytic esterification.
{"title":"Efficient synthesis of tricaproin: catalyst and reaction optimization","authors":"Lenar I. Musin, Renat M. Akhmadullin, Karim R. Gizutdinov, Lilya Sh. Nigmatullina, Leonid V. Lopukhov, Anna N. Zaripova, Dinar D. Nigamatullin, Valerii V. Spiryagin, Huu Quynh Anh Le, Thi Nam Pham, My Uyen Dao, Hong Dung Lai, Hien Y Hoang","doi":"10.1515/pac-2024-0017","DOIUrl":"https://doi.org/10.1515/pac-2024-0017","url":null,"abstract":"This study presents a short communication on exploring, for the first time, a simple approach for the selective and highly effective synthesis of tricaproin by synergistically combining silicon tripolyphosphate and phosphoric acid in the catalytic esterification of glycerol with caproic acid. Results reveal that within the initial hour of the synthesis, the conversion in the presence of the proposed mixture achieved an efficiency of 62.99 %, whereas this figure for individual catalysts only modestly stopped at 27.50 and 11.74 %, respectively. Furthermore, the inherent shortcomings in the tricaprion synthesis, such as catalyst deactivation, resinification of the reaction solution, and generation of numerous by-products, were successfully addressed. The structure of the resultant tricaproin and the possible absence of undesired by-products were confirmed by NMR, mass spectrometry, FT-IR, and TLC. The optimal conditions for the synthesis were also investigated. The study not only contributes a practical and selective synthetic approach for tricaproin but also paves the way for exploring novel avenues to enhance the efficiency of the catalytic esterification.","PeriodicalId":20911,"journal":{"name":"Pure and Applied Chemistry","volume":"15 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140325625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fresh water outflows to sea are a source of marine contamination by radionuclides, most originating from nuclear industry operations. Usually, these lead to small amounts of radionuclides entering the sea, for example, because of the discharge of cooling water. However, under accident conditions large amounts of radionuclides may enter river systems. The extent of radionuclide transport along freshwater systems and their subsequent dispersal in the ocean depends upon their speciation. This manuscript examines the speciation of uranium, with particular reference to sulphate complexes, along the Shu River in Central Asia with a view to predict its transport along such rivers to receiving seas. The speciation of uranium isotopes in the Shu River (at the border of Kazakhstan and Kyrgyzstan) was determined. Calculations were based on the measured concentrations of Ca2+, Mg2+, Na++K+, HCO3−, Cl−, SO42−, and of uranium isotopes. These calculations were determined by either titrimetric methods, gravimetric methods or, for uranium isotopes, by alpha-particle spectrometry. Almost all uranium was present as one of three soluble complexes, either [UO2OH]+, [UO2(CO3)2(H2O)2]2− or [UO2(CO3)3]4−. However, despite the significant concentration of sulphate-ions in the water, especially for the Lower Shu in Kazakhstan, the probability of uranium being present as of sulphate complexes in the analyzed water was very low. The presence of soluble ions is consistent with their mobility along freshwater systems and their transfer to the marine environment. No evidence of an effect from influxes of sulphate was identified.
{"title":"Speciation and mobility of uranium isotopes in the Shu River: impacts for river to sea transfer","authors":"Ilona V. Matveyeva, Mukhambetkali М. Burkitbayev","doi":"10.1515/pac-2023-1009","DOIUrl":"https://doi.org/10.1515/pac-2023-1009","url":null,"abstract":"Fresh water outflows to sea are a source of marine contamination by radionuclides, most originating from nuclear industry operations. Usually, these lead to small amounts of radionuclides entering the sea, for example, because of the discharge of cooling water. However, under accident conditions large amounts of radionuclides may enter river systems. The extent of radionuclide transport along freshwater systems and their subsequent dispersal in the ocean depends upon their speciation. This manuscript examines the speciation of uranium, with particular reference to sulphate complexes, along the Shu River in Central Asia with a view to predict its transport along such rivers to receiving seas. The speciation of uranium isotopes in the Shu River (at the border of Kazakhstan and Kyrgyzstan) was determined. Calculations were based on the measured concentrations of Ca<jats:sup>2+</jats:sup>, Mg<jats:sup>2+</jats:sup>, Na<jats:sup>+</jats:sup>+K<jats:sup>+</jats:sup>, HCO<jats:sub>3</jats:sub> <jats:sup>−</jats:sup>, Cl<jats:sup>−</jats:sup>, SO<jats:sub>4</jats:sub> <jats:sup>2−</jats:sup>, and of uranium isotopes. These calculations were determined by either titrimetric methods, gravimetric methods or, for uranium isotopes, by alpha-particle spectrometry. Almost all uranium was present as one of three soluble complexes, either [UO<jats:sub>2</jats:sub>OH]<jats:sup>+</jats:sup>, [UO<jats:sub>2</jats:sub>(CO<jats:sub>3</jats:sub>)<jats:sub>2</jats:sub>(H<jats:sub>2</jats:sub>O)<jats:sub>2</jats:sub>]<jats:sup>2−</jats:sup> or [UO<jats:sub>2</jats:sub>(CO<jats:sub>3</jats:sub>)<jats:sub>3</jats:sub>]<jats:sup>4−</jats:sup>. However, despite the significant concentration of sulphate-ions in the water, especially for the Lower Shu in Kazakhstan, the probability of uranium being present as of sulphate complexes in the analyzed water was very low. The presence of soluble ions is consistent with their mobility along freshwater systems and their transfer to the marine environment. No evidence of an effect from influxes of sulphate was identified.","PeriodicalId":20911,"journal":{"name":"Pure and Applied Chemistry","volume":"62 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140313439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thermoreversible networks are very attractive materials because of a large variety of suitable thermoreversible chemical bonds which can be used for crosslinking. In future, to certain extent, they may replace so far used irreversibly crosslinked networks and contribute to more sustainable material concepts also in the field of crosslinked elastomers. This paper gives some theoretical basis for understanding the elastic deformation properties of crosslinked polymers and presents some experimental tools for studying deformation behavior not only on a macroscopic length scale but also on a segmental scale. Basic knowledge of these two topics is useful for chemists and material scientists when designing new sustainable elastomeric polymer networks.
{"title":"Flexible polymer networks: rubber elasticity and segmental orientation","authors":"Volker Abetz","doi":"10.1515/pac-2023-1130","DOIUrl":"https://doi.org/10.1515/pac-2023-1130","url":null,"abstract":"Thermoreversible networks are very attractive materials because of a large variety of suitable thermoreversible chemical bonds which can be used for crosslinking. In future, to certain extent, they may replace so far used irreversibly crosslinked networks and contribute to more sustainable material concepts also in the field of crosslinked elastomers. This paper gives some theoretical basis for understanding the elastic deformation properties of crosslinked polymers and presents some experimental tools for studying deformation behavior not only on a macroscopic length scale but also on a segmental scale. Basic knowledge of these two topics is useful for chemists and material scientists when designing new sustainable elastomeric polymer networks.","PeriodicalId":20911,"journal":{"name":"Pure and Applied Chemistry","volume":"1 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140313364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mathematics constitutes a fundamental key for the description and understanding of many phenomena. The chemistry discourse incorporates mathematics in various ways and instances. At educational level, interchanges occur in two directions: mathematics provides support for clearer understanding of chemical phenomena, and the level at which students use the relevant mathematics is an indication of the clarity of their conceptual understanding in chemistry. The present work focuses on an issue for which mathematics tightly links to the conceptual understanding of physical terms – the issue of independent and dependent variables. The definition is in principle well known. On the other hand, the distinction between the two types of variables and their roles is not always clearly underlined at explanation level, and is often not sufficiently internalised by students. This results in a variety of misunderstandings and errors. Careful analysis of students’ works enables the identification of errors that can be tracked down to unclear distinction between the dependent and independent variables in a given context; such errors appear in several areas of chemistry, at both undergraduate and postgraduate levels. The present work considers and analyses a number of representative examples, highlighting the impact of their unclear distinction and the ensuing importance of devoting specific attention to it. Selected addressing approaches from direct experience are included and their outcomes discussed.
{"title":"Crucial role of the internalisation of the distinction between dependent and independent variables for clearer chemistry understanding","authors":"Liliana Mammino","doi":"10.1515/pac-2023-1119","DOIUrl":"https://doi.org/10.1515/pac-2023-1119","url":null,"abstract":"Mathematics constitutes a fundamental key for the description and understanding of many phenomena. The chemistry discourse incorporates mathematics in various ways and instances. At educational level, interchanges occur in two directions: mathematics provides support for clearer understanding of chemical phenomena, and the level at which students use the relevant mathematics is an indication of the clarity of their conceptual understanding in chemistry. The present work focuses on an issue for which mathematics tightly links to the conceptual understanding of physical terms – the issue of independent and dependent variables. The definition is in principle well known. On the other hand, the distinction between the two types of variables and their roles is not always clearly underlined at explanation level, and is often not sufficiently internalised by students. This results in a variety of misunderstandings and errors. Careful analysis of students’ works enables the identification of errors that can be tracked down to unclear distinction between the dependent and independent variables in a given context; such errors appear in several areas of chemistry, at both undergraduate and postgraduate levels. The present work considers and analyses a number of representative examples, highlighting the impact of their unclear distinction and the ensuing importance of devoting specific attention to it. Selected addressing approaches from direct experience are included and their outcomes discussed.","PeriodicalId":20911,"journal":{"name":"Pure and Applied Chemistry","volume":"52 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140313440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Van Cuong Bui, Thi Lan Pham, Thi Lam Nguyen, Thi Kim Chinh Tran, Thi My Hanh Le Le, Xuan Minh Vu, Irina M. Le-Deygen, Chau Anh Nguyen, Thanh Tung Mai, Raa Khimi Shuib
This study aims to synthesize inclusion complex derived from sorafenib (Sor) and hydroxypropyl-β-cyclodextrin (HPβCD) (denoted as [Sor-HPβCD]). The complex of Sor with HPβCD has been synthesized in a mixed solvent of H2O-DMSO, with a DMSO volume fraction of 80 %. The results of FTIR, DSC, and UV–Vis analysis have demonstrated the success of complex formation: the intensity of some characteristic peaks for the Sor binding decreased after complex formation, indicating that a part of the guest molecule has entered the cavity of the HPβCD molecule. This is further supported by the DSC analysis results, showing the transformation of the complex’s crystalline form to an amorphous form. The phase solubility diagram study also indicates that the solubility of Sor significantly increases, approximately 7 times higher than pure Sor, after complex formation. The results of the cell growth inhibition activity test in a water environment show that the complex inhibits the growth of Hep-G2 cells with an IC50 value of 62.4 μg/mL, while pure Sor does not exhibit activity as it is practically insoluble in water.
{"title":"Study on synthesizing the complex of sorafenib with 2-hydroxypropyl-β-cyclodextrin to enhance the anticancer activity of the drug substance","authors":"Van Cuong Bui, Thi Lan Pham, Thi Lam Nguyen, Thi Kim Chinh Tran, Thi My Hanh Le Le, Xuan Minh Vu, Irina M. Le-Deygen, Chau Anh Nguyen, Thanh Tung Mai, Raa Khimi Shuib","doi":"10.1515/pac-2024-0024","DOIUrl":"https://doi.org/10.1515/pac-2024-0024","url":null,"abstract":"This study aims to synthesize inclusion complex derived from sorafenib (Sor) and hydroxypropyl-β-cyclodextrin (HPβCD) (denoted as [Sor-HPβCD]). The complex of Sor with HPβCD has been synthesized in a mixed solvent of H<jats:sub>2</jats:sub>O-DMSO, with a DMSO volume fraction of 80 %. The results of FTIR, DSC, and UV–Vis analysis have demonstrated the success of complex formation: the intensity of some characteristic peaks for the Sor binding decreased after complex formation, indicating that a part of the guest molecule has entered the cavity of the HPβCD molecule. This is further supported by the DSC analysis results, showing the transformation of the complex’s crystalline form to an amorphous form. The phase solubility diagram study also indicates that the solubility of Sor significantly increases, approximately 7 times higher than pure Sor, after complex formation. The results of the cell growth inhibition activity test in a water environment show that the complex inhibits the growth of Hep-G2 cells with an IC<jats:sub>50</jats:sub> value of 62.4 μg/mL, while pure Sor does not exhibit activity as it is practically insoluble in water.","PeriodicalId":20911,"journal":{"name":"Pure and Applied Chemistry","volume":"3 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140297913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Akingbolabo Daniel Ogunlakin, Juliana Bunmi Adetunji, Matthew Iyobhebhe, Toluwanimi Ayonitemi Ajiboye, Gideon Ampoma Gyebi, Peluola Olujide Ayeni, Damilare Iyinkristi Ayokunle, Mubo Adeola Sonibare, Joel Ojogbane Onoja, Enitan O. Adesanya, Omolola Adenike Ajayi-Odoko, Oluwafemi Adeleke Ojo, Sophie Adedamola Adeyeye
Various derivatives of cinnamic acid have been reported to possess significant activities such as antioxidant and hepatoprotective, and neuroprotective activities. Interestingly, testicular toxicity has been linked to several causes, with oxidative damage being one of the pathophysiological mechanisms. 3-(4-methoxyphenyl) acrylic acid (1), a derivative of cinnamic acid, was synthesized and then investigated for its effects on iron-induced testicular injury and oxidative stress via ex vivo and in silico studies, respectively. Evaluations were done on KAD-1’s FRAP, DPPH free radical scavenging activity, and iron chelating potential. Through the ex vivo incubation of tissue supernatant and 0.1 mM FeSO4 for 30 min at 37 °C with different concentration of 1, oxidative testicular damage treatments were induced. The scavenging property of 1 increases significantly (p < 0.05) as the concentration increases when compared with the standard quercetin. The MDA, CAT, ATPase, and ENTPDase activities were reduced when testicular damage was induced (p < 0.05). The group treated with 30 mg/mL had the highest level of MDA. A significant rise in GSH level and activity of SOD were observed. The result obtained indicated that 1 has the potential to prevent oxidative testicular toxicity, as evidenced by its capacity to control nucleotide hydrolysis and reduce oxidative stress. Overall, the results of this experimental study point to some possible uses of 3-(4-methoxyphenyl) acrylic acid (1) in the prevention of oxidative testicular dysfunction. Therefore, 3-(4-methoxyphenyl) acrylic acid (1) would be a good product in developing a medication to alleviate male infertility.
{"title":"3-(4-methoxyphenyl) acrylic acid halts redox imbalance and modulate purinergic enzyme activity in iron-induced testicular injury","authors":"Akingbolabo Daniel Ogunlakin, Juliana Bunmi Adetunji, Matthew Iyobhebhe, Toluwanimi Ayonitemi Ajiboye, Gideon Ampoma Gyebi, Peluola Olujide Ayeni, Damilare Iyinkristi Ayokunle, Mubo Adeola Sonibare, Joel Ojogbane Onoja, Enitan O. Adesanya, Omolola Adenike Ajayi-Odoko, Oluwafemi Adeleke Ojo, Sophie Adedamola Adeyeye","doi":"10.1515/pac-2023-1201","DOIUrl":"https://doi.org/10.1515/pac-2023-1201","url":null,"abstract":"Various derivatives of cinnamic acid have been reported to possess significant activities such as antioxidant and hepatoprotective, and neuroprotective activities. Interestingly, testicular toxicity has been linked to several causes, with oxidative damage being one of the pathophysiological mechanisms. 3-(4-methoxyphenyl) acrylic acid (1), a derivative of cinnamic acid, was synthesized and then investigated for its effects on iron-induced testicular injury and oxidative stress via <jats:italic>ex vivo</jats:italic> and <jats:italic>in silico</jats:italic> studies, respectively. Evaluations were done on KAD-1’s FRAP, DPPH free radical scavenging activity, and iron chelating potential. Through the <jats:italic>ex vivo</jats:italic> incubation of tissue supernatant and 0.1 mM FeSO<jats:sub>4</jats:sub> for 30 min at 37 °C with different concentration of 1, oxidative testicular damage treatments were induced. The scavenging property of 1 increases significantly (<jats:italic>p</jats:italic> < 0.05) as the concentration increases when compared with the standard quercetin. The MDA, CAT, ATPase, and ENTPDase activities were reduced when testicular damage was induced (<jats:italic>p</jats:italic> < 0.05). The group treated with 30 mg/mL had the highest level of MDA. A significant rise in GSH level and activity of SOD were observed. The result obtained indicated that 1 has the potential to prevent oxidative testicular toxicity, as evidenced by its capacity to control nucleotide hydrolysis and reduce oxidative stress. Overall, the results of this experimental study point to some possible uses of 3-(4-methoxyphenyl) acrylic acid (1) in the prevention of oxidative testicular dysfunction. Therefore, 3-(4-methoxyphenyl) acrylic acid (1) would be a good product in developing a medication to alleviate male infertility.","PeriodicalId":20911,"journal":{"name":"Pure and Applied Chemistry","volume":"52 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140297810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cow’s milk proteins are encoded by highly polymorphic genes characterized by several mutations which result in different allelic variants. Each allelic variant has different possible effects on cheese-making properties and on human health. β-casein A1-A3-I-B, k-casein B and β-lactoglobulin B are supposed to influence milk cheese-making properties by increasing cheese or milk yield, by varying chemical parameters, by having small casein micelle size, and by influencing rennet coagulation time (RCT) and curd-firming rate (CFR). In addition, β-casein A1-B are also considered to be a risk factor for different health diseases such as ischemic heart disease (IHD), type 1 diabetes (T1D), decreased glutathione (GSH) concentration, and milk intolerance. An LC-MS method was applied to profile, for the first time, the main milk proteins genetic variants from Aosta Valley autochtonous cattle breeds. Analyses performed on milk collected from bovines of three cattle breeds (Red Pied – VRP, Black Pied – VNP and Chestnut – CAS), either from IAR experimental farm or from herds of dairy-producers in Aosta Valley region, showed quite high frequencies of β-casein A2 and A3/I, and low frequencies of β-casein A1. Moreover, low frequencies of β-casein B in VRP breed and high frequencies of the same variant in CAS, and VNP breeds have been found. As far as k-casein is concerned allelic variant B is the most diffused in VRP while allelic variant A in VNP and CAS breeds. Finally, β-lactoglobulin most diffused allelic variant for all breeds is B. Results suggest that Aosta Valley milk has good cheese-making properties and good frequencies of β-casein A2 which may be related to beneficial effects on human health. In light of these results, it is important to develop breeding programs which take into consideration milk proteins polymorphisms to further increase the milk suitability for cheese-making process and to decrease the presence of β-casein A1 and B in drinking milk which can be a risk factor for human health.
牛奶蛋白质是由高度多态的基因编码的，这些基因具有多种变异，从而产生不同的等位基因变体。每种等位基因变体对奶酪的制作特性和人体健康都有不同的影响。β-酪蛋白 A1-A3-I-B、k-酪蛋白 B 和 β-乳球蛋白 B 可通过增加奶酪或牛奶产量、改变化学参数、具有较小的酪蛋白胶束尺寸以及影响凝乳酶凝结时间（RCT）和凝乳固化率（CFR）来影响牛奶奶酪的制作特性。此外，β-酪蛋白 A1-B 还被认为是导致缺血性心脏病（IHD）、1 型糖尿病（T1D）、谷胱甘肽（GSH）浓度降低和牛奶不耐受等不同健康疾病的危险因素。我们首次采用 LC-MS 方法分析了奥斯塔河谷自交系牛种的主要牛奶蛋白质基因变异。对从 IAR 实验牧场或奥斯塔河谷地区奶牛生产者的牛群中采集的三个牛种（红皮牛 - VRP、黑皮牛 - VNP 和栗牛 - CAS）的牛奶进行的分析表明，β-酪蛋白 A2 和 A3/I 的频率相当高，而 β-酪蛋白 A1 的频率较低。此外，在 VRP 品种中，β-酪蛋白 B 的频率较低，而在 CAS 和 VNP 品种中，该变体的频率较高。就 k-酪蛋白而言，等位基因变异 B 在 VRP 中最常见，而等位基因变异 A 则在 VNP 和 CAS 品种中最常见。结果表明，奥斯塔河谷牛奶具有良好的奶酪制作特性和较高的β-酪蛋白 A2 频率，这可能与对人类健康的有益影响有关。鉴于这些结果，重要的是要制定考虑到牛奶蛋白质多态性的育种计划，以进一步提高牛奶对奶酪制作工艺的适用性，并减少饮用牛奶中可能成为人类健康风险因素的 β-酪蛋白 A1 和 B 的存在。
{"title":"Milk protein polymorphisms of Aosta Valley cattle breeds","authors":"Mathieu Merlet, Luca Vernetti-Prot, Sabina Valentini","doi":"10.1515/pac-2023-0014","DOIUrl":"https://doi.org/10.1515/pac-2023-0014","url":null,"abstract":"Cow’s milk proteins are encoded by highly polymorphic genes characterized by several mutations which result in different allelic variants. Each allelic variant has different possible effects on cheese-making properties and on human health. β-casein A1-A3-I-B, k-casein B and β-lactoglobulin B are supposed to influence milk cheese-making properties by increasing cheese or milk yield, by varying chemical parameters, by having small casein micelle size, and by influencing rennet coagulation time (RCT) and curd-firming rate (CFR). In addition, β-casein A1-B are also considered to be a risk factor for different health diseases such as ischemic heart disease (IHD), type 1 diabetes (T1D), decreased glutathione (GSH) concentration, and milk intolerance. An LC-MS method was applied to profile, for the first time, the main milk proteins genetic variants from Aosta Valley autochtonous cattle breeds. Analyses performed on milk collected from bovines of three cattle breeds (Red Pied – VRP, Black Pied – VNP and Chestnut – CAS), either from IAR experimental farm or from herds of dairy-producers in Aosta Valley region, showed quite high frequencies of β-casein A2 and A3/I, and low frequencies of β-casein A1. Moreover, low frequencies of β-casein B in VRP breed and high frequencies of the same variant in CAS, and VNP breeds have been found. As far as k-casein is concerned allelic variant B is the most diffused in VRP while allelic variant A in VNP and CAS breeds. Finally, β-lactoglobulin most diffused allelic variant for all breeds is B. Results suggest that Aosta Valley milk has good cheese-making properties and good frequencies of β-casein A2 which may be related to beneficial effects on human health. In light of these results, it is important to develop breeding programs which take into consideration milk proteins polymorphisms to further increase the milk suitability for cheese-making process and to decrease the presence of β-casein A1 and B in drinking milk which can be a risk factor for human health.","PeriodicalId":20911,"journal":{"name":"Pure and Applied Chemistry","volume":"11 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140197928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Disproportionation and comproportionation reactions have become routinely proposed events in modern synthetic endevours that use nickel catalysts. This new found appreciation from practitioners in the field for these electron transfer reactions has largely stemmed from our improved understanding of catalytic reactions. These studies have shown evidence of the ability of nickel complexes to occupy odd and even oxidation states which are critical to dictating reactivity. Comproportionation and disproportionation reactions shuttle nickel complexes between these oxidation states and are essential to the formation of either on-cycle or off-cycle species. This review will cover these fundamental reactions, and provide information about their role in catalysis.
{"title":"Advances in understanding comproportionation and disproportionation in nickel catalysis","authors":"Craig S. Day","doi":"10.1515/pac-2024-0106","DOIUrl":"https://doi.org/10.1515/pac-2024-0106","url":null,"abstract":"Disproportionation and comproportionation reactions have become routinely proposed events in modern synthetic endevours that use nickel catalysts. This new found appreciation from practitioners in the field for these electron transfer reactions has largely stemmed from our improved understanding of catalytic reactions. These studies have shown evidence of the ability of nickel complexes to occupy odd and even oxidation states which are critical to dictating reactivity. Comproportionation and disproportionation reactions shuttle nickel complexes between these oxidation states and are essential to the formation of either on-cycle or off-cycle species. This review will cover these fundamental reactions, and provide information about their role in catalysis.","PeriodicalId":20911,"journal":{"name":"Pure and Applied Chemistry","volume":"231 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140205674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The surface tension of ionic liquids with the tris(pentafluoroethyl)trifluorophosphate (FAP) anion were measured using a home-built surface tensiometer. A high-vacuum line was used to pre-evacuate the ionic liquids prior to analyses, ensuring that the samples were free of dissolved gases, water, and volatile impurities. Using the pendant drop method, measurements were performed in a custom-built surface tension vacuum or gas cell, in the presence of nitrogen and carbon dioxide gas. To calibrate the instrument, surface tension measurement of known liquids was also performed. Results show that the presence of saturated carbon dioxide led to the lowering of measured surface tension values, indicating the adsorption of CO2 on the ionic liquid surface.
{"title":"Surface tension measurement of FAP-based ionic liquid pendant drops in a high vacuum/gas cell","authors":"Julius Kim Tiongson, Imee Su Martinez","doi":"10.1515/pac-2023-1113","DOIUrl":"https://doi.org/10.1515/pac-2023-1113","url":null,"abstract":"The surface tension of ionic liquids with the tris(pentafluoroethyl)trifluorophosphate (FAP) anion were measured using a home-built surface tensiometer. A high-vacuum line was used to pre-evacuate the ionic liquids prior to analyses, ensuring that the samples were free of dissolved gases, water, and volatile impurities. Using the pendant drop method, measurements were performed in a custom-built surface tension vacuum or gas cell, in the presence of nitrogen and carbon dioxide gas. To calibrate the instrument, surface tension measurement of known liquids was also performed. Results show that the presence of saturated carbon dioxide led to the lowering of measured surface tension values, indicating the adsorption of CO<jats:sub>2</jats:sub> on the ionic liquid surface.","PeriodicalId":20911,"journal":{"name":"Pure and Applied Chemistry","volume":"18 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140198265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oanh H. Nguyen, Huy T. A. Nguyen, Luon Tan Nguyen, Nga H. N. Do, Lam Dai Tran, Viet T. Tran, Phung K. Le, Kien A. Le
Biomass-based aerogels are of interest due to their abundant precursors, ease of functionalization, eco-friendliness, low cost, and effectiveness in dye-contaminated water treatment. Coconut pith (CP) known as a by-product after coconut processing is a sponge-like and lightweight material discarded in large volumes. For the first time, carbon micro-particles resulting from two-step treatment and pyrolysis of CP have been successfully incorporated with chitosan to produce aerogel composites by high-speed homogenization and freeze-drying. After pretreatment, holocellulose content and crystallinity index of the recovered CP pulp are respectively 75.4 and 58.6 % along with a solid recovery rate of 27.5 %. Characteristic properties of the aerogel composites are featured by their density as low as 15.23–28.17 mg/cm3, remarkably high porosity of 98.17–99.05 %, and Young’s modulus of 1.64–12.23 kPa. Synergistic effects of the porous network, electrostatic interactions between both amine groups in chitosan and carbon surface with methyl orange (MO) cause the as-fabricated aerogel composites to achieve an extremely high adsorption capacity of 454.13 mg/g and removal efficiency of 92.32 % at initial MO concentration of 500 mg/L. Therefore, the CP-derived carbon/chitosan aerogel composites synthesized from a feasible procedure exhibit their great potential in enhancing the value of coconut waste and dealing with dye-contaminated water pollution by simple and economical adsorption.
{"title":"Bio-based aerogel composites of coconut pith-derived carbon and chitosan for efficient anionic dye-polluted water treatment","authors":"Oanh H. Nguyen, Huy T. A. Nguyen, Luon Tan Nguyen, Nga H. N. Do, Lam Dai Tran, Viet T. Tran, Phung K. Le, Kien A. Le","doi":"10.1515/pac-2024-0102","DOIUrl":"https://doi.org/10.1515/pac-2024-0102","url":null,"abstract":"Biomass-based aerogels are of interest due to their abundant precursors, ease of functionalization, eco-friendliness, low cost, and effectiveness in dye-contaminated water treatment. Coconut pith (CP) known as a by-product after coconut processing is a sponge-like and lightweight material discarded in large volumes. For the first time, carbon micro-particles resulting from two-step treatment and pyrolysis of CP have been successfully incorporated with chitosan to produce aerogel composites by high-speed homogenization and freeze-drying. After pretreatment, holocellulose content and crystallinity index of the recovered CP pulp are respectively 75.4 and 58.6 % along with a solid recovery rate of 27.5 %. Characteristic properties of the aerogel composites are featured by their density as low as 15.23–28.17 mg/cm<jats:sup>3</jats:sup>, remarkably high porosity of 98.17–99.05 %, and Young’s modulus of 1.64–12.23 kPa. Synergistic effects of the porous network, electrostatic interactions between both amine groups in chitosan and carbon surface with methyl orange (MO) cause the as-fabricated aerogel composites to achieve an extremely high adsorption capacity of 454.13 mg/g and removal efficiency of 92.32 % at initial MO concentration of 500 mg/L. Therefore, the CP-derived carbon/chitosan aerogel composites synthesized from a feasible procedure exhibit their great potential in enhancing the value of coconut waste and dealing with dye-contaminated water pollution by simple and economical adsorption.","PeriodicalId":20911,"journal":{"name":"Pure and Applied Chemistry","volume":"30 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140198220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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