Lihui Yuan, Ping Zhu, Yu Wang, Xia Dong, Dujin Wang
Conventional polymers have typically been used in the packaging of various electronic devices; however, due to the inherent electrically insulating properties these materials fail to dissipate static charges. To address this issue, novel poly(ether-b-amide) (PEBA) segmented copolymers consisting of uniform rigid oxalamide and flexible polyethylene glycol (PEG) were synthesized via melt polycondensation. The influence of PEG molecular weight and the spacer length separating two oxalamide units on the condensed structure, mechanical performance, and antistatic properties was systematically investigated. Fourier-transform infrared (FTIR) demonstrated strongly hydrogen bonded and highly ordered oxalamide hard segments with the degree of ordering between 71 and 85 % even at low levels. Mechanical behavior results showed that segmented copolymers have an obvious yield point, an elastic modulus between 20 and 30 MPa, and strain at break exceeding 2000 %. Meanwhile, such copolymers possessed low surface resistivity, as low as 107 Ω, which is significantly less than that of commercial antistatic additives. The antistatic effect of PEBA on polyamide 6 (PA6) was also investigated, revealing that when the content reached 30 wt%, the surface resistivity of the alloys decreased from 1013 Ω to 1011 Ω and remained stable after 40 days, even after water washing treatment. Overall, these findings illustrate that the newly synthesized PEBA copolymers demonstrate outstanding long-term antistatic properties and provide valuable insights for the development of polyether-based multiblock copolymer antistatic agents.
{"title":"The preparation of permanent antistatic additive based on poly(ether-b-amide) copolymers and its modification effect on polyamide 6","authors":"Lihui Yuan, Ping Zhu, Yu Wang, Xia Dong, Dujin Wang","doi":"10.1515/pac-2023-1132","DOIUrl":"https://doi.org/10.1515/pac-2023-1132","url":null,"abstract":"Conventional polymers have typically been used in the packaging of various electronic devices; however, due to the inherent electrically insulating properties these materials fail to dissipate static charges. To address this issue, novel poly(ether-<jats:italic>b</jats:italic>-amide) (PEBA) segmented copolymers consisting of uniform rigid oxalamide and flexible polyethylene glycol (PEG) were synthesized via melt polycondensation. The influence of PEG molecular weight and the spacer length separating two oxalamide units on the condensed structure, mechanical performance, and antistatic properties was systematically investigated. Fourier-transform infrared (FTIR) demonstrated strongly hydrogen bonded and highly ordered oxalamide hard segments with the degree of ordering between 71 and 85 % even at low levels. Mechanical behavior results showed that segmented copolymers have an obvious yield point, an elastic modulus between 20 and 30 MPa, and strain at break exceeding 2000 %. Meanwhile, such copolymers possessed low surface resistivity, as low as 10<jats:sup>7</jats:sup> Ω, which is significantly less than that of commercial antistatic additives. The antistatic effect of PEBA on polyamide 6 (PA6) was also investigated, revealing that when the content reached 30 wt%, the surface resistivity of the alloys decreased from 10<jats:sup>13</jats:sup> Ω to 10<jats:sup>11</jats:sup> Ω and remained stable after 40 days, even after water washing treatment. Overall, these findings illustrate that the newly synthesized PEBA copolymers demonstrate outstanding long-term antistatic properties and provide valuable insights for the development of polyether-based multiblock copolymer antistatic agents.","PeriodicalId":20911,"journal":{"name":"Pure and Applied Chemistry","volume":"131 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139956214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Noviany Noviany, Hasnah Osman, Suriyati Mohamad, Bambang Irawan, Wisnu Ananta Kusuma, Jhons F. Suwandi, Sutopo Hadi, Nanik S. Aminah
A new dimer of natural isoflavonoid along with some known flavonoid compounds was successfully isolated from the roots of Indonesian Sesbania grandiflora plant using ethyl acetate extraction. The new compound specified as naturally bi-isoflavonoid with (4→6) inter-isoflavanyl linkage and four known flavonoids xenognosin B, liquiritigenin, 7,2′4′-trihydroxyisoflavone, demethylvestitol, and 1,1′-bi-2-naphthol was isolated and the antituberculosis activity of the compounds was studied. The structure of all compounds was elucidated with the aid of 1D and 2D NMR, UV spectroscopy, and HRESI mass spectrometry. The data obtained were also compared with the previous published data. Among compounds, 1,1′-bi-2-naphthol was found to exhibit the highest activity against Mycobacterium tuberculosis H37Rv with the MIC’s value of 10.9 µM while the biisoflavonoid with (4→6) inter-isoflavanyl linkage showed moderate activity with the MIC’s value of 92.2 nM, compared with isozianid as a positive control with the MIC’s value of 0.569 nM. It is worth to note that 1,1′-bi-2-naphthol and biisoflavonoid with (4→6) inter-isoflavanyl linkage were isolated for the first time from a natural source. Both compounds have been previously reported as synthetic compounds, which is synonymous with 3,4- trans-4-[(3S)-7,2′-dihydroxy-4′-methoxyisoflavan-6-yl]-7,2′-dihydroxy-4′-methoxyisoflavan and 1,1′-bi-2-naphthol, respectively. In this respect, the results of this study suggest that the roots of S. grandiflora is a potential source of new natural product compounds, with promising bioactivities.
利用乙酸乙酯萃取法成功地从印度尼西亚大叶芝麻植物的根部分离出了一种新的天然异黄酮二聚体和一些已知的黄酮类化合物。分离出的新化合物是具有 (4→6) 异黄烷间连接的天然双异黄酮，以及四种已知的黄酮类化合物 xenognosin B、liquiritigenin、7,2′4′-三羟基异黄酮、demethylvestitol 和 1,1′-bi-2-naphthol ，并对这些化合物的抗结核活性进行了研究。利用一维和二维核磁共振、紫外光谱和 HRESI 质谱分析法阐明了所有化合物的结构。获得的数据还与之前发表的数据进行了比较。在这些化合物中，1,1′-bi-2-萘酚对结核分枝杆菌 H37Rv 的活性最高，其 MIC 值为 10.9 µM，而具有 (4→6) 间异黄酮连接的生物黄酮类化合物则表现出中等活性，其 MIC 值为 92.2 nM，而异嗪酸作为阳性对照，其 MIC 值为 0.569 nM。值得注意的是，1,1′-bi-2-萘酚和具有（4→6）间异黄烷酰基连接的生物黄酮类化合物是首次从天然来源中分离出来。这两种化合物以前都曾被报道为合成化合物，分别与 3,4-反式-4-[(3S)-7,2′-二羟基-4′-甲氧基异黄烷-6-基]-7,2′-二羟基-4′-甲氧基异黄烷和 1,1′-双-2-萘酚同义。因此，本研究的结果表明，大花茜草的根是新天然产物化合物的潜在来源，具有良好的生物活性。
{"title":"Two new naturally dimers constituent from Indonesian Sesbania grandiflora plant and their bioactivity","authors":"Noviany Noviany, Hasnah Osman, Suriyati Mohamad, Bambang Irawan, Wisnu Ananta Kusuma, Jhons F. Suwandi, Sutopo Hadi, Nanik S. Aminah","doi":"10.1515/pac-2023-1112","DOIUrl":"https://doi.org/10.1515/pac-2023-1112","url":null,"abstract":"A new dimer of natural isoflavonoid along with some known flavonoid compounds was successfully isolated from the roots of Indonesian <jats:italic>Sesbania grandiflora</jats:italic> plant using ethyl acetate extraction. The new compound specified as naturally bi-isoflavonoid with (4→6) inter-isoflavanyl linkage and four known flavonoids xenognosin B, liquiritigenin, 7,2′4′-trihydroxyisoflavone, demethylvestitol, and 1,1′-bi-2-naphthol was isolated and the antituberculosis activity of the compounds was studied. The structure of all compounds was elucidated with the aid of 1D and 2D NMR, UV spectroscopy, and HRESI mass spectrometry. The data obtained were also compared with the previous published data. Among compounds, 1,1′-bi-2-naphthol was found to exhibit the highest activity against <jats:italic>Mycobacterium tuberculosis</jats:italic> H37Rv with the MIC’s value of 10.9 µM while the biisoflavonoid with (4→6) inter-isoflavanyl linkage showed moderate activity with the MIC’s value of 92.2 nM, compared with isozianid as a positive control with the MIC’s value of 0.569 nM. It is worth to note that 1,1′-bi-2-naphthol and biisoflavonoid with (4→6) inter-isoflavanyl linkage were isolated for the first time from a natural source. Both compounds have been previously reported as synthetic compounds, which is synonymous with 3,4- <jats:italic>trans</jats:italic>-4-[(3<jats:italic>S</jats:italic>)-7,2′-dihydroxy-4′-methoxyisoflavan-6-yl]-7,2′-dihydroxy-4′-methoxyisoflavan and 1,1′-bi-2-naphthol, respectively. In this respect, the results of this study suggest that the roots of <jats:italic>S. grandiflora</jats:italic> is a potential source of new natural product compounds, with promising bioactivities.","PeriodicalId":20911,"journal":{"name":"Pure and Applied Chemistry","volume":"194 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139924197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Several biomass wastes, including forest wastes, bagasse, algae, and others, have been studied to determine their biosorption capability for adsorbing different ranges of heavy metals in the literature. Most experimental studies have not clearly shown the impact of functional groups in biomaterials discovered by FTIR analysis on the investigated biosorption processes. Because of this, the findings of this study indicate that it is necessary to theoretically investigate the influence of identified functional groups (as determined by FTIR analysis) on the biosorption activities of the sorbent or biomaterial prepared for the removal of cadmium metal from an effluent. Using the most geometrical structure for cadmium (Cd) metal, a series of identified functional groups for the sorbent were analyzed using FTIR to determine their mode and intensity of interaction to computationally understand better how they each influence the biosorption of cadmium. This was done to determine how each functional group contributes to the intensity of the cadmium biosorption, using a ground-state B3LYP density functional theory calculation performed in a Spartan 20 simulation package utilizing the 6-31G* and LANL2DZ > Kr basis sets. According to the study’s findings, carboxylate (–COO*) had the most significant effect on cadmium biosorption activity of all the functional groups studied due to the stronger binding strength obtained for it. Therefore, this research suggests exploring biomaterials with greater intensity for carboxylate function, which would aid cadmium sorption efficiency in an effluent treatment process.
{"title":"Unraveling the influence of biomaterial’s functional groups in Cd biosorption: a density functional theory calculation","authors":"Toyese Oyegoke, Chidiebere Millicent Igwebuike, Ademola Oyegoke","doi":"10.1515/pac-2023-1103","DOIUrl":"https://doi.org/10.1515/pac-2023-1103","url":null,"abstract":"Several biomass wastes, including forest wastes, bagasse, algae, and others, have been studied to determine their biosorption capability for adsorbing different ranges of heavy metals in the literature. Most experimental studies have not clearly shown the impact of functional groups in biomaterials discovered by FTIR analysis on the investigated biosorption processes. Because of this, the findings of this study indicate that it is necessary to theoretically investigate the influence of identified functional groups (as determined by FTIR analysis) on the biosorption activities of the sorbent or biomaterial prepared for the removal of cadmium metal from an effluent. Using the most geometrical structure for cadmium (Cd) metal, a series of identified functional groups for the sorbent were analyzed using FTIR to determine their mode and intensity of interaction to computationally understand better how they each influence the biosorption of cadmium. This was done to determine how each functional group contributes to the intensity of the cadmium biosorption, using a ground-state B3LYP density functional theory calculation performed in a Spartan 20 simulation package utilizing the 6-31G* and LANL2DZ > Kr basis sets. According to the study’s findings, carboxylate (–COO*) had the most significant effect on cadmium biosorption activity of all the functional groups studied due to the stronger binding strength obtained for it. Therefore, this research suggests exploring biomaterials with greater intensity for carboxylate function, which would aid cadmium sorption efficiency in an effluent treatment process.","PeriodicalId":20911,"journal":{"name":"Pure and Applied Chemistry","volume":"28 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139756646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shaoyan Fan, Koki Nasu, Yukio Takeuchi, Miho Fukuda, Hirotsugu Arai, Keisuke Taniguchi, Yuichi Onda
While 20 % of radionuclides released from the Fukushima Daiichi Nuclear Power Plant accident had been deposited in the terrestrial environment, rivers remain the long-term source for 137Cs, primarily through particulate transfer, from terrestrial to marine ecosystems. In this study, we estimated the suspended 137Cs flux to the ocean at 11 sites in the coastal area between October 2012 and December 2020 to be 17 TBq, based on our long-term monitoring data of concentrations of suspended 137Cs and suspended solids. The cumulative loss of suspended 137Cs from each site to the ocean ranged from 0.1 % to 1.7 % of initial deposition throughout the observation period, depending on the effect of dam lakes and normalized river discharge. The higher loss is also thought to be the large outflow of runoff during the typhoon. The current level of the suspended 137Cs concentrations was lowered to 1/10–1/100 of those immediately after the accident. The average value of the decreasing trend for each site was approximated using the equation: y = a1 e −k1t + a2 e −k2t. The rate constant k1 is higher in areas with intensive land use, such as pastures, bare land, and water surfaces, and k2 is lower in urban areas.
{"title":"Transport of radioactive materials from terrestrial to marine environments in Fukushima over the past decade","authors":"Shaoyan Fan, Koki Nasu, Yukio Takeuchi, Miho Fukuda, Hirotsugu Arai, Keisuke Taniguchi, Yuichi Onda","doi":"10.1515/pac-2023-0802","DOIUrl":"https://doi.org/10.1515/pac-2023-0802","url":null,"abstract":"While 20 % of radionuclides released from the Fukushima Daiichi Nuclear Power Plant accident had been deposited in the terrestrial environment, rivers remain the long-term source for <jats:sup>137</jats:sup>Cs, primarily through particulate transfer, from terrestrial to marine ecosystems. In this study, we estimated the suspended <jats:sup>137</jats:sup>Cs flux to the ocean at 11 sites in the coastal area between October 2012 and December 2020 to be 17 TBq, based on our long-term monitoring data of concentrations of suspended <jats:sup>137</jats:sup>Cs and suspended solids. The cumulative loss of suspended <jats:sup>137</jats:sup>Cs from each site to the ocean ranged from 0.1 % to 1.7 % of initial deposition throughout the observation period, depending on the effect of dam lakes and normalized river discharge. The higher loss is also thought to be the large outflow of runoff during the typhoon. The current level of the suspended <jats:sup>137</jats:sup>Cs concentrations was lowered to 1/10–1/100 of those immediately after the accident. The average value of the decreasing trend for each site was approximated using the equation<jats:italic>: y</jats:italic> = <jats:italic>a</jats:italic>1 <jats:italic>e</jats:italic> −<jats:italic>k</jats:italic> <jats:sub>1</jats:sub> <jats:italic>t</jats:italic> + <jats:italic>a</jats:italic>2 <jats:italic>e</jats:italic> −<jats:italic>k</jats:italic> <jats:sub>2</jats:sub>t. The rate constant <jats:italic>k</jats:italic> <jats:sub>1</jats:sub> is higher in areas with intensive land use, such as pastures, bare land, and water surfaces, and <jats:italic>k</jats:italic> <jats:sub>2</jats:sub> is lower in urban areas.","PeriodicalId":20911,"journal":{"name":"Pure and Applied Chemistry","volume":"17 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139756650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this personal perspective, we reflect on our personal journey, highlighting the significance that role models and mentoring played in them, and explore how they benefit early-career researchers, promote academic success, and contribute to the overall growth of the academic community. We – the co-authors of this article (Prof. Tatjana Parac-Vogt and Dr. Ann van der Jeugd) – share some special connections: we were both presidents of Belgium Women in Science (BeWiSe), a non-profit association that promotes the role and position of women in science in Belgium (Tatjana from 2012 to 2016; Ann from 2020 to 2024), and we have a thriving mentor/mentee relationship, which started in 2015 through the BeWiSe mentoring programme.
在这篇个人视角的文章中，我们回顾了自己的个人历程，强调了榜样和指导在其中发挥的重要作用，并探讨了榜样和指导如何惠及早期研究人员、促进学术成功以及推动学术界的整体发展。我们--这篇文章的共同作者（Tatjana Parac-Vogt 教授和 Ann van der Jeugd 博士）--有着一些特殊的联系：我们都曾是比利时科学界妇女组织（BeWiSe）的主席（Tatjana 从 2012 年至 2016 年；Ann 从 2020 年至 2024 年），该组织是一个非营利性协会，旨在促进比利时科学界妇女的作用和地位。
{"title":"Empowering women in science through role models, mentors, and support groups: a personal perspective","authors":"Ann Van der Jeugd, Tatjana N. Parac-Vogt","doi":"10.1515/pac-2023-1205","DOIUrl":"https://doi.org/10.1515/pac-2023-1205","url":null,"abstract":"In this personal perspective, we reflect on our personal journey, highlighting the significance that role models and mentoring played in them, and explore how they benefit early-career researchers, promote academic success, and contribute to the overall growth of the academic community. We – the co-authors of this article (Prof. Tatjana Parac-Vogt and Dr. Ann van der Jeugd) – share some special connections: we were both presidents of Belgium Women in Science (BeWiSe), a non-profit association that promotes the role and position of women in science in Belgium (Tatjana from 2012 to 2016; Ann from 2020 to 2024), and we have a thriving mentor/mentee relationship, which started in 2015 through the BeWiSe mentoring programme.","PeriodicalId":20911,"journal":{"name":"Pure and Applied Chemistry","volume":"17 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139756908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this work, three organotin (IV) derivatives namely dibutyltin(IV) di-2-hydroxybenzoate (DBT2-HBz) (2), dibutyltin(IV) di-3-hydroxybenzoate (DBT3-HBz) (3) and dibutyltin(IV) di-4-hydroxybenzoate (DBT4-HBz)) (4) were synthesized and tested as disinfectant against pathogenic bacteria, Staphylococcus aureus. Compounds 2–4 were prepared by reacting dibutyltin(IV) oxide (DBTO) (1) with 2-hydroxybenzoic acid (2-HHBz), 3-hydroxybenzoic acid (3-HHBz) and 4-hydroxybenzoic acid (4-HHBz). The synthesized compounds were characterized by spectroscopic techniques including UV–Vis, FT-IR, 1H NMR, and 13C NMR, and micro-elemental analyzer. The optical density (OD) of compounds was measured by UV–Vis at 600 nm, which showed good bioactivity against the S. aureus. The data obtained indicated that compound 4 has higher bioactivity than compound 2 and 3, and the positive control using a commercial disinfectant containing 5 % benzalkonium chloride. The optimum bioactivity of compound 4 was observed at a concentration of 5 × 10−4 M with a contact time of 10 min, as shown by the decrease in absorbance from 0.6092 to 0.4005. Compound 2 was optimal at a concentration of 5 × 10−4 M with a contact time of 10 min, and the absorbance decreased from 0.6092 to 0.4416. Compound 3 and positive control showed a smaller decrease in absorbance compared to compound 4 and 2. Overall, the results obtained indicated that the compounds synthesized have promising potential as disinfectant against pathogenic bacteria.
{"title":"Synthesis, characterization, and bioactivity test of dibutyltin(IV) dihydroxyibenzoate as disinfectant agent","authors":"Sutopo Hadi, Hidayatul Mustafidah, Yandri Yandri, Wasinton Simanjuntak, Tati Suhartati","doi":"10.1515/pac-2023-1102","DOIUrl":"https://doi.org/10.1515/pac-2023-1102","url":null,"abstract":"In this work, three organotin (IV) derivatives namely dibutyltin(IV) di-2-hydroxybenzoate (DBT2-HBz) (2), dibutyltin(IV) di-3-hydroxybenzoate (DBT3-HBz) (3) and dibutyltin(IV) di-4-hydroxybenzoate (DBT4-HBz)) (4) were synthesized and tested as disinfectant against pathogenic bacteria, <jats:italic>Staphylococcus aureus</jats:italic>. Compounds 2–4 were prepared by reacting dibutyltin(IV) oxide (DBTO) (1) with 2-hydroxybenzoic acid (2-HHBz), 3-hydroxybenzoic acid (3-HHBz) and 4-hydroxybenzoic acid (4-HHBz). The synthesized compounds were characterized by spectroscopic techniques including UV–Vis, FT-IR, <jats:sup>1</jats:sup>H NMR, and <jats:sup>13</jats:sup>C NMR, and micro-elemental analyzer. The optical density (OD) of compounds was measured by UV–Vis at 600 nm, which showed good bioactivity against the <jats:italic>S. aureus</jats:italic>. The data obtained indicated that compound 4 has higher bioactivity than compound 2 and 3, and the positive control using a commercial disinfectant containing 5 % benzalkonium chloride. The optimum bioactivity of compound 4 was observed at a concentration of 5 × 10<jats:sup>−4</jats:sup> M with a contact time of 10 min, as shown by the decrease in absorbance from 0.6092 to 0.4005. Compound 2 was optimal at a concentration of 5 × 10<jats:sup>−4</jats:sup> M with a contact time of 10 min, and the absorbance decreased from 0.6092 to 0.4416. Compound 3 and positive control showed a smaller decrease in absorbance compared to compound 4 and 2. Overall, the results obtained indicated that the compounds synthesized have promising potential as disinfectant against pathogenic bacteria.","PeriodicalId":20911,"journal":{"name":"Pure and Applied Chemistry","volume":"28 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139756689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medicinal plant Cassia sieberiana root bark was investigated for phytochemicals and Anti-Breast Cancer cells (MCF-7) properties, using Chemical Separations and MTT assay in vitro. The C. sieberiana root bark was extracted with soxhlet extractor using different solvents based on polarity guided method and the respective extracts were concentrated under reduced pressure. These extracts were screened for their phytochemicals qualitatively using standard methods. Percentage Yields and Physico-Chemical Evaluation of the Extracts from the various fractions were recorded. The results of phytochemicals screening revealed the presence of some secondary metabolites of pharmacological significance in the Methyl acetate, MeOH and 70 % MeOH root bark extracts including Saponins, Quinones, Phenolic, Steroids, Tannins, Flavounoids, Terpenoids, Anthraquinones, Cardiac-glycosides, Alkaloids, Carbohydrates, Glycosides and Coumarins. Results obtained from MTT assay revealed that Extracts of MeOH and 70 % MeOH samples shown a certain degree of inhibition towards MCF-7 cell line. IC50 were calculated using Graph Pad Prism 6 and results shown that IC50 of 245.3 μg/ml and 239.6 μg/ml dose dependent inhibitions in MCF-7 cells respectively, compared to Oxaliplatin IC50 of 38.04 μg/ml. Therefore, 70 % MeOH sample with IC50 of 239.6 μg/ml have shown more potential of inhibiting breast cancer cell, MCF-7 cells line. The inhibition of the root bark is attributed to some of the phytochemicals present in the plant.
{"title":"MTT assay of human anti-breast cancer cells (MCF-7) in vitro potentials and phytochemicals screening of the root bark extracts from Cassia sieberiana","authors":"Labaran Abdulkadir Magashi","doi":"10.1515/pac-2023-1108","DOIUrl":"https://doi.org/10.1515/pac-2023-1108","url":null,"abstract":"Medicinal plant <jats:italic>Cassia sieberiana</jats:italic> root bark was investigated for phytochemicals and Anti-Breast Cancer cells (MCF-7) properties, using Chemical Separations and MTT assay <jats:italic>in vitro</jats:italic>. The <jats:italic>C. sieberiana</jats:italic> root bark was extracted with soxhlet extractor using different solvents based on polarity guided method and the respective extracts were concentrated under reduced pressure. These extracts were screened for their phytochemicals qualitatively using standard methods. Percentage Yields and Physico-Chemical Evaluation of the Extracts from the various fractions were recorded. The results of phytochemicals screening revealed the presence of some secondary metabolites of pharmacological significance in the Methyl acetate, MeOH and 70 % MeOH root bark extracts including <jats:italic>Saponins, Quinones, Phenolic, Steroids, Tannins, Flavounoids, Terpenoids, Anthraquinones, Cardiac-glycosides, Alkaloids, Carbohydrates, Glycosides and Coumarins</jats:italic>. Results obtained from MTT assay revealed that Extracts of MeOH and 70 % MeOH samples shown a certain degree of inhibition towards MCF-7 cell line. IC<jats:sub>50</jats:sub> were calculated using Graph Pad Prism 6 and results shown that IC<jats:sub>50</jats:sub> of 245.3 μg/ml and 239.6 μg/ml dose dependent inhibitions in MCF-7 cells respectively, compared to <jats:italic>Oxaliplatin</jats:italic> IC<jats:sub>50</jats:sub> of 38.04 μg/ml. Therefore, 70 % MeOH sample with IC<jats:sub>50</jats:sub> of 239.6 μg/ml have shown more potential of inhibiting breast cancer cell, MCF-7 cells line. The inhibition of the root bark is attributed to some of the phytochemicals present in the plant.","PeriodicalId":20911,"journal":{"name":"Pure and Applied Chemistry","volume":"18 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139756643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tati Suhartati, Andi Irawan, Hendri Ropingi, Yandri Yandri, Sutopo Hadi
In this study, artocarpin compound was successfully isolated from the root wood of the Pudau plant (Artocarpus kemando Miq.) and subsequently tested as antidiabetic and antibacterial agent against Staphylococcus aureus and Salmonella typhi. The procedure applied for isolation involved maceration using methanol followed by partition and purification using column chromatography. The purity of the compound was determined using thin layer chromatography and melting point measurement. The compound was subsequently characterized via UV–vis and IR spectroscopy. The compound isolated was obtained as a yellow amorphous solid and has melting point of 168.7–173.6 °C. The antidiabetic tests were performed against α-amylase enzyme, using the compound with the concentrations of 250, 500, 750, and 1000 ppm. The highest inhibition percentage of 43.33 ± 0.02 % was achieved with the use of 750 ppm of the compound and the IC50 value is 32 661.08 ppm. Antibacterial tests were performed with concentration variations of 0.3, 0.4, and 0.5 mg/disc. S. aureus and S. typhi bacteria showed high inhibition at a concentration of 0.5 mg/disc with inhibition zone diameters of 8 and 7 mm, respectively (moderate category).
{"title":"Antidiabetic and antibacterial activities of artocarpin: a flavonoid compound isolated from the root wood of the Pudau plant (Artocarpus kemando Miq.)","authors":"Tati Suhartati, Andi Irawan, Hendri Ropingi, Yandri Yandri, Sutopo Hadi","doi":"10.1515/pac-2023-1131","DOIUrl":"https://doi.org/10.1515/pac-2023-1131","url":null,"abstract":"In this study, artocarpin compound was successfully isolated from the root wood of the Pudau plant (<jats:italic>Artocarpus kemando</jats:italic> Miq.) and subsequently tested as antidiabetic and antibacterial agent against <jats:italic>Staphylococcus aureus</jats:italic> and <jats:italic>Salmonella typhi</jats:italic>. The procedure applied for isolation involved maceration using methanol followed by partition and purification using column chromatography. The purity of the compound was determined using thin layer chromatography and melting point measurement. The compound was subsequently characterized via UV–vis and IR spectroscopy. The compound isolated was obtained as a yellow amorphous solid and has melting point of 168.7–173.6 °C. The antidiabetic tests were performed against α-amylase enzyme, using the compound with the concentrations of 250, 500, 750, and 1000 ppm. The highest inhibition percentage of 43.33 ± 0.02 % was achieved with the use of 750 ppm of the compound and the IC<jats:sub>50</jats:sub> value is 32 661.08 ppm. Antibacterial tests were performed with concentration variations of 0.3, 0.4, and 0.5 mg/disc. <jats:italic>S. aureus</jats:italic> and <jats:italic>S. typhi</jats:italic> bacteria showed high inhibition at a concentration of 0.5 mg/disc with inhibition zone diameters of 8 and 7 mm, respectively (moderate category).","PeriodicalId":20911,"journal":{"name":"Pure and Applied Chemistry","volume":"17 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139756647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A novel copper iodide hybrid compound, (DABCO-H)CuKI3, featuring a perovskite structure is here reported. Characterization techniques, including single crystal X-ray diffraction, X-ray photoelectron spectroscopy (XPS), and photoluminescence studies, elucidate the structural and luminescent properties. The compound exhibits blue phosphorescence, attributed to mixed metal-to-ligand and halide-to-ligand charge transfer transitions, as supported by density functional theory (DFT) calculations and XPS valence band analysis. Furthermore, (DABCO-H)CuKI3 displays a remarkable adsorption capacity towards methylene blue dye. Kinetic modelling reveals that both film and intra-particle diffusion processes contribute to the adsorption rate.
本文报告了一种新型碘化铜杂化化合物 (DABCO-H)CuKI3，它具有包晶结构。包括单晶 X 射线衍射、X 射线光电子能谱（XPS）和光致发光研究在内的表征技术阐明了该化合物的结构和发光特性。密度泛函理论（DFT）计算和 XPS 价带分析证明，该化合物具有蓝色磷光，归因于金属到配体和卤化物到配体的混合电荷转移跃迁。此外，(DABCO-H)CuKI3 对亚甲基蓝染料具有显著的吸附能力。动力学模型显示，薄膜和颗粒内扩散过程都对吸附速率有贡献。
{"title":"Bridging two worlds: (DABCO-H)CuKI3 a hybrid copper iodide phosphor with a perovskite structure","authors":"Lidia Armelao, Maria Rando, Silvia Carlotto, Irene Motta, Gregorio Bottaro, Marzio Rancan","doi":"10.1515/pac-2023-1023","DOIUrl":"https://doi.org/10.1515/pac-2023-1023","url":null,"abstract":"A novel copper iodide hybrid compound, (DABCO-H)CuKI<jats:sub>3</jats:sub>, featuring a perovskite structure is here reported. Characterization techniques, including single crystal X-ray diffraction, X-ray photoelectron spectroscopy (XPS), and photoluminescence studies, elucidate the structural and luminescent properties. The compound exhibits blue phosphorescence, attributed to mixed metal-to-ligand and halide-to-ligand charge transfer transitions, as supported by density functional theory (DFT) calculations and XPS valence band analysis. Furthermore, (DABCO-H)CuKI<jats:sub>3</jats:sub> displays a remarkable adsorption capacity towards methylene blue dye. Kinetic modelling reveals that both film and intra-particle diffusion processes contribute to the adsorption rate.","PeriodicalId":20911,"journal":{"name":"Pure and Applied Chemistry","volume":"24 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139664117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anna Schulte, Daniel Wesner, Mareike Müller, Holger Schönherr
A systematic study on the surface-initiated polymerization of di(ethylene glycol) methyl ether methacrylate (DEGMA) by atom transfer radical polymerization (ATRP) from glass, silicon, titanium as well as tissue culture polystyrene (TCPS) is reported in an attempt to expand the known thermoresponsive poly(di(ethylene glycol) methyl ether methacrylate) (PDEGMA) cell release layers on gold to other substrates. The use of these substrate materials requires an altered immobilization chemistry to couple a bromide containing ATRP initiator to the surfaces. Using aminosilanes or polydopamine as coupling layers for the attachment of α-bromoisobutyryl bromide (BiBB) and the direct functionalization of surface hydroxyl groups with trichlorosilane-functionalized ATRP initiators all surfaces studied were shown to facilitate the growth of PDEGMA brushes using the same conditions that were reported previously for polymerization on gold. The brush layers obtained were characterized systematically using wetting, ellipsometry, X-ray photoelectron spectroscopy (XPS) as well as atomic force microscopy (AFM) analyses. Selective cell release and separation of PaTu 8988t and NIH 3T3 cells, which are known to exhibit different behavior after temperature drop-induced brush swelling, was observed for all substrates, albeit for different brush thicknesses, implying variations in initiator and also PDEGMA grafting density. The successful modification of biomedically relevant materials (Ti and TCPS) implies that the previously reported stem cell purification and selective cell release of various cell types, which is facilitated by PDEGMA brushes, can be realized and consequently scaled up in the future.
{"title":"Thermo-responsive poly(di(ethylene glycol) methyl ether methacrylate) brushes as substrate-independent release coatings for cell culture and selective cell separation and purification","authors":"Anna Schulte, Daniel Wesner, Mareike Müller, Holger Schönherr","doi":"10.1515/pac-2023-1007","DOIUrl":"https://doi.org/10.1515/pac-2023-1007","url":null,"abstract":"A systematic study on the surface-initiated polymerization of di(ethylene glycol) methyl ether methacrylate (DEGMA) by atom transfer radical polymerization (ATRP) from glass, silicon, titanium as well as tissue culture polystyrene (TCPS) is reported in an attempt to expand the known thermoresponsive poly(di(ethylene glycol) methyl ether methacrylate) (PDEGMA) cell release layers on gold to other substrates. The use of these substrate materials requires an altered immobilization chemistry to couple a bromide containing ATRP initiator to the surfaces. Using aminosilanes or polydopamine as coupling layers for the attachment of α-bromoisobutyryl bromide (BiBB) and the direct functionalization of surface hydroxyl groups with trichlorosilane-functionalized ATRP initiators all surfaces studied were shown to facilitate the growth of PDEGMA brushes using the same conditions that were reported previously for polymerization on gold. The brush layers obtained were characterized systematically using wetting, ellipsometry, X-ray photoelectron spectroscopy (XPS) as well as atomic force microscopy (AFM) analyses. Selective cell release and separation of PaTu 8988t and NIH 3T3 cells, which are known to exhibit different behavior after temperature drop-induced brush swelling, was observed for all substrates, albeit for different brush thicknesses, implying variations in initiator and also PDEGMA grafting density. The successful modification of biomedically relevant materials (Ti and TCPS) implies that the previously reported stem cell purification and selective cell release of various cell types, which is facilitated by PDEGMA brushes, can be realized and consequently scaled up in the future.","PeriodicalId":20911,"journal":{"name":"Pure and Applied Chemistry","volume":"23 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139664092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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