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Pharmacognostical, Phytochemical and Anti-Parkinson’s profile ofMucuna pruriens 麻豆的生药学、植物化学及抗帕金森病研究
Pub Date : 2021-12-21 DOI: 10.52711/2321-5836.2021.00025
Pranali Kurund, Swathi Gandla
Mucuna pruriens is a recognized herbal drug which contains numerous pharmacological activities. Mucuna pruriens commonly known as cow-age or cowitch or velvet bean or Alkushi. Mucuna pruriens has been traditionally used as a food source in a number of countries. It belongs to the Mucuna genus of Fabaceae family and it is cultivated in Asia, America, Africa, and the Pacific Islands. Mucuna pruriens is used in India since 1500 B.C. it contains various important phytoconstituents which are for medicinal purposes. Pods of Mucuna pruriens are used as a vegetable for human consumption. Its fresh leaves are used as animal fodder. Mucuna contains various species, 130 species of Mucuna are metioned in this review. The present review is an attempt to provide all the reported details of information regarding to the Pharmacognostical, Phytochemical and Anti-Parkinson’s Profile of Mucuna pruriens.
麻豆是公认的具有多种药理活性的草药。绒毛虫俗称牛龄或牛、绒豆或麻豆。在许多国家,传统上把毛粘虫作为食物来源。它属于豆科的粘豆属,在亚洲、美洲、非洲和太平洋岛屿都有种植。自公元前1500年以来,印度就开始使用粘虫,它含有各种重要的药用植物成分。粘豆豆荚是一种供人类食用的蔬菜。它的新鲜叶子被用作动物饲料。粘液属植物种类繁多,本文综述了130种粘液属植物。本综述试图提供所有已报道的有关痒麻的生药学、植物化学和抗帕金森病的详细信息。
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引用次数: 1
Review on Adverse effects or side effects of Remdisivir 瑞地西韦的不良反应或副作用综述
Pub Date : 2021-12-21 DOI: 10.52711/2321-5836.2021.00030
Ganesh G. Dhakad, Rohit V. Patil, Tejas I. Chaudhari, Paresh A. Patil
In March 2020, the World Health Organization declared the spread of SARS-CoV-2 a global pandemic. To date, coronavirus disease-2019 (COVID-19) has spread to over 200 countries, leading to over 1.6 million cases and over 99,000 deaths. Given that there is neither a vaccine nor proven treatment for COVID-19, there is currently an urgent need for effective pharmacotherapy. To address the need for an effective treatment of SARS-CoV-2 during the worldwide pandemic, this systematic review of intravenous (IV) remdesivir was performed. Remdesivir, an anti-viral prodrug originally developed to treat Ebola virus disease, has shown broad spectrum activity against the Coronavirus family. A recent case report reported improvement of clinical symptoms with remdesivir in a patient with COVID-19. After conducting a systematic search of 18 clinical trial registries and three large scientific databases, we identified 86 potentially eligible items. Following removal of duplicates (n = 21), eligible studies were reviewed independently by two authors. After the first round of screening, inter-rater agreement was 98.5% (κ = 0.925). After the second round of full-text screening, inter-rater agreement was 100%. A total of seven ongoing and recruiting clinical trials of remdesivir (100–200 milligrams, intravenous [IV]) were included. We identified the following primary outcomes: patients discharged (n = 2); time to clinical status improvement (n = 2); improved O2 saturation (n = 2); body temperature normalization (n = 2); and clinical status (n = 1). Secondary outcomes in all identified studies included documentation of adverse events. Phase 3 trials are expected to be completed between April 2020–2023. Therefore, despite supportive data from in vitro and in vivo studies, the clinical effectiveness of IV remdesivir for treatment of COVID-19 and potential side effects remain incompletely defined in the human population. But the remdesivir is also harmful for the people because of it can have some side effects such as mentioned in the following information. There are so many type of disease started form the treatment of COVID-19 with the Remdesivir that also mentioned in the following review paper.
2020年3月,世界卫生组织宣布SARS-CoV-2蔓延为全球大流行。迄今为止,2019冠状病毒病(COVID-19)已蔓延到200多个国家,导致160多万例病例和9.9万多人死亡。鉴于目前既没有针对COVID-19的疫苗,也没有经过验证的治疗方法,目前迫切需要有效的药物治疗。为了解决在全球大流行期间有效治疗SARS-CoV-2的需求,对静脉注射(IV)瑞德西韦进行了系统评价。瑞德西韦是一种最初用于治疗埃博拉病毒病的抗病毒前药,已显示出对冠状病毒家族的广谱活性。最近的一份病例报告称,一名COVID-19患者使用瑞德西韦后临床症状有所改善。在对18个临床试验注册中心和3个大型科学数据库进行系统搜索后,我们确定了86个潜在的符合条件的项目。删除重复研究(n = 21)后,由两位作者独立审查符合条件的研究。第一轮筛选后,评分间一致性为98.5% (κ = 0.925)。在第二轮全文筛选后,评分者之间的一致性为100%。共纳入7项正在进行和正在招募的瑞德西韦(100-200毫克,静脉注射[IV])临床试验。我们确定了以下主要结局:患者出院(n = 2);到临床状态改善时间(n = 2);改善氧饱和度(n = 2);体温恢复正常(n = 2);和临床状态(n = 1)。所有确定的研究的次要结局包括不良事件的记录。第三阶段试验预计将于2020年4月至2023年完成。因此,尽管有来自体外和体内研究的支持性数据,但在人群中,静脉注射瑞德西韦治疗COVID-19的临床有效性和潜在副作用仍未完全确定。但是瑞德西韦对人也是有害的,因为它可能有一些副作用,比如下面的信息中提到的。有很多类型的疾病开始于用Remdesivir治疗COVID-19,这也在下面的综述文章中提到。
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引用次数: 2
The Pharmacological Study of Antidiabetatic Property of Ficus racemosa Leaves by Observing Different Aspects 从不同角度观察总状榕叶抗糖尿病的药理作用
Pub Date : 2021-12-21 DOI: 10.52711/2321-5836.2021.00032
Prasad. J. Rodge, Irfan Sayyed, Vitthal Bhosle, R. S. Jain, Azam Z. Shaikh
Ficus racemosa is belong to the family of Moraceae.It is a famous medicinal plant in India which is used in traditional system of medicine for long period of time for the treatment of various diseases like liver disorder, diarrhora, inflamatory condition, ulcer, urinary disorder, antifungal and diabetics. This plant is very useful from ancient time of maintained in Ayurveda, Siddha, Unani and Homeopathy. Plant are one of the most important role/source in medicine. The commen name of Ficus racemosa is “Audumber” and “Umbar”. In Thervada Buddhism the plant is said to have as the tree for achived enlightenment by the 26th Loard Buddha, Konaagama. This udumbara is deciduous tree. The more information is described below and the people are moving towards ayurvedic preprations.
总状榕属桑科植物。它是印度著名的药用植物,长期用于传统医学系统,用于治疗各种疾病,如肝病,腹泻,炎症,溃疡,泌尿系统疾病,抗真菌和糖尿病。这种植物自古以来就在阿育吠陀、悉达陀、乌纳尼和顺势疗法中非常有用。植物是最重要的药物来源之一。总状榕的俗名是“Audumber”和“Umbar”。在上座部佛教中,这种植物被认为是第二十六世佛陀获得启蒙的树。这是一种落叶树。下面描述了更多的信息,人们正在转向阿育吠陀制剂。
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引用次数: 1
A Short Review on study on different Clinical trials Performed on drugs before it Comes into The Market 药物上市前不同临床试验的研究综述
Pub Date : 2021-12-21 DOI: 10.52711/2321-5836.2021.00027
G. Y. Pawar, Rushikesh R. Chaudhari, T. N. Sonawane, J. S. Desale, Suraj. K. Ishikar
To study the topic we have used the detail study of various phases of clinical trials to support the topic, after the study we evaluated the various information that has been gathered. Although our paper describe the detail study, objectives behind the study, outcomes conclusion of clinical study. In our study are found that How the drug comes in the market and what are the various phases through which the drug has to cross. In our study we also understood that without the involvement of animals clinical trials won't be further conducted Through graphs one can easily understand the overviews of clinical trials study. Other supportive points like. Types of clinical trialsSignificanceRate of pharmacist in clinical trialsHave been highlighted to support our article.
为了研究这个主题,我们使用了临床试验各个阶段的详细研究来支持这个主题,研究结束后,我们评估了已经收集到的各种信息。虽然我们的论文描述了详细的研究,研究背后的目的,临床研究的结果结论。在我们的研究中,我们发现药物是如何进入市场的,以及药物必须经过哪些不同的阶段。在我们的研究中,我们也明白了没有动物的参与,临床试验将无法进一步进行。通过图表,我们可以很容易地了解临床试验研究的概况。其他支持性观点,比如。临床试验的类型强调了药剂师在临床试验中的重要性,以支持我们的文章。
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引用次数: 1
Adaptogenic Agents - Proper Channel for Health 适应性制剂——健康的正确途径
Pub Date : 2021-08-20 DOI: 10.52711/2321-5836.2021.00022
P. ShahaA., Meera Deshmukh, Pranati Tilak
Stress causes aging of majority of people in India which has impact on overall personal development, economic status, social and clinical aspect of an individual. Stress and aging causes less life period that should be considered as a threat with respect to family. It causes unsatisfaction during life period of individual. It is a necessity and challenging to treat this disorder using herbal adaptogenic agents. This article presents causes of stress, the medicinal herbs as adaptogens, the marketed formulation of adaptogens and successive findings through it.
压力导致印度大多数人老龄化,这对个人的整体发展、经济地位、社会和临床方面都有影响。压力和衰老导致生命周期缩短,这应该被视为对家庭的威胁。它会导致个体在生命周期中的不满足。使用草药治疗这种疾病是必要的,也是具有挑战性的。本文介绍了应激的原因,作为适应原的草药,适应原的上市配方和通过它的连续发现。
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引用次数: 0
Bacteriology of wound infections and Antibiotic susceptibility pattern of the Isolates 伤口感染的细菌学及分离株的抗生素敏感性
Pub Date : 2021-08-20 DOI: 10.52711/2321-5836.2021.00017
V. N., Ashli Raj V, Nisharani Ss, Li Al, Chandini S, S. R
Wound infection has always been a major complication of surgery and trauma. The aim of our study was to determine the bacteriology of wound infections and to study the antibiotic susceptibility pattern of the isolates. The study was conducted in tertiary care hospital, Erode. The design of the study was a prospective type. Pus swabs / specimens were collected from hospitalized patients who developed wound infections. Bacterial pathogens were identified by conventional biochemical methods according to standard microbiological techniques. Antimicrobial susceptibility was performed on Muller – Hinton agar by the standard disk diffusion method. The incidence of wound infection was more common in males (63%) than in females (37%). Out of 100 culture positive samples, 61 samples were collected from diabetic ulcer patients, 20 samples were from ulcer patients, and 19 samples were from post operative patients. Of the 100 samples (culture positive), 71% collected samples showed mono-microbial growth, 29% showed two type of microbial growth. The prevalence of S. aureus (62.87%) from different wound infections was found to be high, followed by E.coli (48.65%), Klebsiella (30.21%), Pseudomonas (22.16%). Organisms showed diversity in the sensitivity pattern towards the antibiotics tested. High level of sensitivity was observed to Imipenem, Piperacillin tazobactum and Amikacin. High level of resistance was observed to Cephalosporins and Penicillin derivatives. We concluded that the sensitivity pattern of the antibiotics is not based on the infection site but on the type of organisms. This study gives us an insight to the current state of causative pathogens and their sensitivity to different antibiotics used in tertiary care hospital, Erode. The data of this study may be used to determine trends in antimicrobial susceptibilities and to modify antibiotic policy of the Hospital.
伤口感染一直是外科手术和创伤的主要并发症。本研究的目的是确定伤口感染的细菌学,并研究分离株的抗生素敏感性模式。这项研究是在罗德三级护理医院进行的。本研究设计为前瞻性研究。从发生伤口感染的住院患者收集脓拭子/标本。根据标准微生物学技术,采用常规生化方法对病原菌进行鉴定。采用标准圆盘扩散法对Muller - Hinton琼脂进行药敏试验。伤口感染的发生率男性(63%)高于女性(37%)。100份培养阳性样本中,61份来自糖尿病溃疡患者,20份来自溃疡患者,19份来自手术后患者。在100份样本(培养阳性)中,71%的样本显示单一微生物生长,29%的样本显示两种微生物生长。不同伤口感染中金黄色葡萄球菌感染率最高(62.87%),其次是大肠杆菌(48.65%)、克雷伯菌(30.21%)、假单胞菌(22.16%)。微生物对所测抗生素的敏感性表现出多样性。对亚胺培南、哌拉西林、他唑巴坦和阿米卡星均有较高的敏感性。观察到对头孢菌素和青霉素衍生物的高度耐药。我们得出结论,抗生素的敏感性模式不是基于感染部位,而是基于生物体的类型。这项研究让我们了解到目前的状态的致病病原体和他们的敏感性对不同的抗生素使用三级护理医院,侵蚀。本研究的数据可用于确定抗菌药物敏感性的趋势和修改医院的抗生素政策。
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引用次数: 0
Remodeling in the Prefrontal Cortex of a Brain-related to Higher Executive Functions in Adolescence: Its effects on Behavior 与青少年高级执行功能相关的大脑前额叶皮层重塑:其对行为的影响
Pub Date : 2021-08-20 DOI: 10.52711/2321-5836.2021.00021
T. Nwe, S. Aye, K. Yee, S. Lwin, V. Bhagat
Adolescence is a critical stage of the developmental trajectory, where a child’s transition to independent living may result in healthy or unhealthy styles. During this period, it is easier to mend an individual as a healthy adult; at the same time, misguided children may enter into risky behaviors. The aim of the study to get an insight into changing brains of adolescents and their behavioral outcomes. The current review search engine proceeds with reviewing the literature in the past through electronic databases such as PubMed, Medline, and Scopus databases using keywords such as adolescent stage, the brain of teenagers, risk behaviors, reduction in gray matter in the prefrontal cortex. The current study reviewed and analyzed 20 articles. The reviewed articles would increase the awareness and insights regarding brain changes and their behavioral outcomes. This insightful information’s drawn out of the study may help professionals and parents who intervene the adolescent’s problem behaviors.
青春期是发展轨迹的关键阶段,儿童向独立生活的过渡可能导致健康或不健康的生活方式。在这一时期,更容易把一个人改造成一个健康的成年人;同时,被误导的孩子可能会做出危险的行为。这项研究的目的是深入了解青少年大脑的变化及其行为结果。目前的综述搜索引擎通过PubMed、Medline、Scopus等电子数据库,使用青少年阶段、青少年大脑、危险行为、前额皮质灰质减少等关键词,对过去的文献进行检索。目前的研究回顾和分析了20篇文章。这些评论文章将增加对大脑变化及其行为结果的认识和见解。从这项研究中得出的这些深刻的信息可能会帮助那些干预青少年问题行为的专业人士和父母。
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引用次数: 0
Mucormycosis 毛霉菌病
Pub Date : 2021-08-20 DOI: 10.1016/b978-0-323-37677-8.50071-1
Mahesh Babasaheb Kolap, Abhijeet Vijay Dashwant
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引用次数: 0
Awareness regarding Antibiotic Stewardship among nurses at selected hospitals, Chennai 钦奈选定医院护士对抗生素管理的认识
Pub Date : 2021-08-20 DOI: 10.52711/2321-5836.2021.00018
Manju Sudhakar, Sasikala Dhakshinamoorthy
Background: Antibiotics are medicines that fight bacterial infections. They can save lives if they are used correctly, but nowadays antibiotic resistance has become a real problem.1 Infections by resistant microorganisms do not respond treatment, which prolongs the hospital stay, and increases the risk of death. Moreover, if the treatment fails or if the response to treatment is slow, the patient is contagious for longer, which increases the likelihood of transmission of resistant microorganisms.2 The clinical outcome can be improved with optimization of antibiotic practices. The aim of the study was to assess the level of awareness regarding Antibiotic stewardship among nurses. Methods andMaterials: A cross sectional descriptive correlational research design was adopted to assess the awareness of nurses on antibiotic stewardship. An extensive review of literature and guidance from the experts formed the foundation to the development of the tools such as demographic variables proforma, MCQ questionnaire on antibiotic stewardship in google form. The present study was conducted in selected tertiary care center at Chennai, among 60 nurses selected by purposive sampling technique. After obtaining setting permission and research participants’ consent, a brief introduction of the research was given. Then the data were collected using the predetermined tools through email using google forms. The collected data were organized and analyzed using descriptive and inferential statistics. Results: More than half of nurses had adequate overall knowledge on antibiotic stewardship (55%), majority of them had adequate knowledge in antibiotic treatment (60%) and nurses’ responsibility (63.33%). Around half of them had adequate knowledge in drug related side effects (46.67%) and its causative agents (50%). Conclusion: The present study reveals the necessity for continuous nursing education for knowledge update regarding importance of nurses regarding antibiotic stewardship.
背景:抗生素是对抗细菌感染的药物。如果使用得当,抗生素可以挽救生命,但现在抗生素耐药性已成为一个真正的问题耐药微生物感染对治疗无效,从而延长住院时间,增加死亡风险。此外,如果治疗失败或治疗反应缓慢,患者的传染性会持续更长时间,这就增加了耐药微生物传播的可能性临床结果可以通过优化抗生素实践来改善。本研究的目的是评估护士对抗生素管理的认识水平。方法与材料:采用横断面描述性相关研究设计,对护士抗生素管理意识进行评估。对文献的广泛审查和专家的指导为开发诸如人口变量形式、谷歌形式抗生素管理MCQ问卷等工具奠定了基础。本研究在钦奈选定的三级护理中心进行,采用目的抽样方法选取60名护士。在获得设置许可和研究参与者的同意后,对研究进行了简要介绍。然后使用预定的工具通过电子邮件和谷歌表单收集数据。收集到的数据使用描述性和推理性统计进行组织和分析。结果:半数以上的护士对抗生素管理有足够的总体知识(55%),大部分护士对抗生素治疗有足够的知识(60%),护士的责任(63.33%)。对药物相关副作用(46.67%)及其致病因子(50%)有充分认识的约占半数。结论:本研究揭示了持续护理教育的必要性,以更新护士对抗生素管理重要性的知识。
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引用次数: 0
Therapeutic uses of Vilwa (Aegle marmelos) in Ayurveda with Pharmacological Evidence 在阿育吠陀医学中的治疗用途与药理学证据
Pub Date : 2021-05-15 DOI: 10.52711/2321-5836.2021.00011
P. Panda, Banamali Das, G. Bhuyan, M. M. Rao
Aegle marmelos, a plant indigenous to India has been used by the inhabitants of the Indian subcontinent for over 5000 years. The leaves, bark, roots, fruits and seeds are used extensively in the Indian traditional system of medicine the Ayurveda and in various folk medicine to treat myriad ailments. It possesses broad range of therapeutic effects that includes free radical scavenging, antioxidant, inhibition of lipid peroxidation, antibacterial, antiviral, anti-diarrheal, gastroprotective, antiulcerative colitis, hepatoprotective, anti-diabetic, cardioprotective and radioprotective effects.In Ayurveda it has been used for the treatment of Atisara (loose stool), Pravahika (dysentery), Shoth (generalised or localised swelling), Gulma (localised gas in abdominal region), Arsha ( haemorrhoids), Grahani (irritable bowel syndrome), Pandu (anaemia), Shvasa (respiratory disorders), Hikka (hiccough), Kasa (cough), Parshwashula (pain in chest bilaterally), Hritshula (cardiac problems), Udararoga (disorders of GI tract), Halimaka (a type of jaundice), Vataroga (nervine disorder).
马蜜瓜,一种原产于印度的植物,已经被印度次大陆的居民使用了5000多年。它的叶子、树皮、根、果实和种子在印度传统医学体系阿育吠陀和各种民间医学中被广泛用于治疗无数的疾病。它具有广泛的治疗作用,包括自由基清除、抗氧化、抑制脂质过氧化、抗菌、抗病毒、抗腹泻、胃保护、抗溃疡性结肠炎、肝保护、抗糖尿病、心脏保护和辐射保护作用。在阿育吠陀中,它被用于治疗Atisara(大便疏松)、Pravahika(痢疾)、Shoth(全身或局部肿胀)、Gulma(腹部局部胀气)、Arsha(痔疮)、Grahani(肠易激综合征)、Pandu(贫血)、Shvasa(呼吸系统疾病)、Hikka(打嗝)、Kasa(咳嗽)、Parshwashula(双侧胸痛)、Hritshula(心脏问题)、Udararoga(胃肠道疾病)、Halimaka(黄疸的一种)、Vataroga(神经紊乱)。
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引用次数: 2
期刊
Research Journal of Pharmacology and Pharmacodynamics
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