Pub Date : 2022-04-29DOI: 10.52711/2321-5836.2022.00016
Sangita P. Shirsat, Kaveri P. Tambe, Gayatri D. Patil, Ganesh G. Dhakad
Curcuma aromatica is also a familiar Chinese herb used for treating diseases with blood stasis and has been consider as an effective anticancer herb. The rhizomes of Curcuma aromatic are used in original medicine for exterior applications on skin diseases, sprain, bruise, in snake poison, holdup the ageing process, pain relief, protecting against liver diseases and also to enhance complexion. The constituents identified in the oil is alpha-pinene, beta-pinene, camphene, 1,8-cineol, isofurano-germacrene, borneol, isoborneol, beta-curcumene, ar-curcumene, xanthorrhizol, germacrone, camphor, and curzerenone and the constituent in oil was found to differ from place to place. Bioactive compounds, counting 1, 8-cineole, ar-curcumene, ar-turmerone, β-elemene, camphor, curcumol, curdione, germacrone, linalool, xanthorrhizol, and zingiberene, from the essential oil of C. aromatica have been verified to possess anticancer properties. Usually used as an anti- inflammatory agent. It possesses a wide range of activities like Anti –inflammatory, anti-tumor, immunological effects, wound healing, anti -fungal, anti -oxidant, anti - microbial, anti-diabetic, anti-platelet and mosquito repellent activity of wild turmeric. The use of analgesic drugs, such as opiates and NSAIDs, for pain relief has been stagnated as these drugs are reported to have adverse side effects, including addiction and gastrointestinal disorders.
{"title":"Review on Curcuma aromatic as an Herbal medicine","authors":"Sangita P. Shirsat, Kaveri P. Tambe, Gayatri D. Patil, Ganesh G. Dhakad","doi":"10.52711/2321-5836.2022.00016","DOIUrl":"https://doi.org/10.52711/2321-5836.2022.00016","url":null,"abstract":"Curcuma aromatica is also a familiar Chinese herb used for treating diseases with blood stasis and has been consider as an effective anticancer herb. The rhizomes of Curcuma aromatic are used in original medicine for exterior applications on skin diseases, sprain, bruise, in snake poison, holdup the ageing process, pain relief, protecting against liver diseases and also to enhance complexion. The constituents identified in the oil is alpha-pinene, beta-pinene, camphene, 1,8-cineol, isofurano-germacrene, borneol, isoborneol, beta-curcumene, ar-curcumene, xanthorrhizol, germacrone, camphor, and curzerenone and the constituent in oil was found to differ from place to place. Bioactive compounds, counting 1, 8-cineole, ar-curcumene, ar-turmerone, β-elemene, camphor, curcumol, curdione, germacrone, linalool, xanthorrhizol, and zingiberene, from the essential oil of C. aromatica have been verified to possess anticancer properties. Usually used as an anti- inflammatory agent. It possesses a wide range of activities like Anti –inflammatory, anti-tumor, immunological effects, wound healing, anti -fungal, anti -oxidant, anti - microbial, anti-diabetic, anti-platelet and mosquito repellent activity of wild turmeric. The use of analgesic drugs, such as opiates and NSAIDs, for pain relief has been stagnated as these drugs are reported to have adverse side effects, including addiction and gastrointestinal disorders.","PeriodicalId":20945,"journal":{"name":"Research Journal of Pharmacology and Pharmacodynamics","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87416857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Novel coronavirus also known as severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) was emerged from Wuhan, China and have taken catastrophic form globally. India being a dense populated country is also affected by it’s deadly infection. Bats were considered as its primary host but COVID-19 disease became pandemic via human to human transmission by droplet nuclei. The incubation period ranges upto 14 days and main symptoms of disease were noticed as atypical pneumonia, fever, difficult breathing, decreased SPO2 level and ultimately death due to respiratory failure depending upon immune status of the patients. Coronaviruses are positive-sense, single-stranded RNA viruses and harbour a genome (30 kb) consisting of two terminal untranslated regions and twelve putative functional open reading frames (ORFs), encoding for non-structural and structural proteins. There are sixteen putative non-structural proteins, including proteases, RNA-dependent RNA polymerase, helicase, other proteins involved in the transcription and replication of SARS-CoV-2, and four structural proteins, including spike protein (S), envelope (E), membrane (M), and nucleocapsid (N). SARS-CoV-2 infection, with a heavy viral load in the body, destroys the human lungs through cytokine storm, especially in elderly persons and people with immunosuppressed disorders. A number of drugs have been repurposed and employed, but still, no specific antiviral medicine has been approved by the FDA to treat this disease. This review provides a current status of the COVID-19, epidemiology, an overview of phylogeny, mode of action, diagnosis, and possible treatment methods and vaccines.
{"title":"Review of Novel Corona Virus Disease (Covid-19) in India","authors":"Ghanshyam Sevak, Yashpal Singh Chauhan, Narendra B. Parihar, Mahendra Singh Rathore","doi":"10.52711/2321-5836.2022.00018","DOIUrl":"https://doi.org/10.52711/2321-5836.2022.00018","url":null,"abstract":"Novel coronavirus also known as severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) was emerged from Wuhan, China and have taken catastrophic form globally. India being a dense populated country is also affected by it’s deadly infection. Bats were considered as its primary host but COVID-19 disease became pandemic via human to human transmission by droplet nuclei. The incubation period ranges upto 14 days and main symptoms of disease were noticed as atypical pneumonia, fever, difficult breathing, decreased SPO2 level and ultimately death due to respiratory failure depending upon immune status of the patients. Coronaviruses are positive-sense, single-stranded RNA viruses and harbour a genome (30 kb) consisting of two terminal untranslated regions and twelve putative functional open reading frames (ORFs), encoding for non-structural and structural proteins. There are sixteen putative non-structural proteins, including proteases, RNA-dependent RNA polymerase, helicase, other proteins involved in the transcription and replication of SARS-CoV-2, and four structural proteins, including spike protein (S), envelope (E), membrane (M), and nucleocapsid (N). SARS-CoV-2 infection, with a heavy viral load in the body, destroys the human lungs through cytokine storm, especially in elderly persons and people with immunosuppressed disorders. A number of drugs have been repurposed and employed, but still, no specific antiviral medicine has been approved by the FDA to treat this disease. This review provides a current status of the COVID-19, epidemiology, an overview of phylogeny, mode of action, diagnosis, and possible treatment methods and vaccines.","PeriodicalId":20945,"journal":{"name":"Research Journal of Pharmacology and Pharmacodynamics","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82370484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-29DOI: 10.52711/2321-5836.2022.00019
K. Sekhri, S. Bhanwra, R. Nandha, S. Aditya, Deepak Bhasin
Chloroquine was discovered in 1934 and since then it is used as an antimalarial drug saving millions of lives. Chloroquine and its analogue Hydroxychloroquine possess pleotropic pharmacological actions and are of proven value in multiple conditions ranging from protozoal to autoimmune diseases. Advantage with these drugs is their well-documented tolerability profile. In Severe Acute Respiratory Syndrome Corona virus-2 (SARS-CoV-2), these drugs in vitro showed promising results working at multiple sites ranging from prevention of entry of the virus into human cells, halting the multiplication by altering the pH of internal organelles towards basic side and via exocytosis. These drugs also act as immunomodulators to prevent flare up of cytokines and interleukin cascade, thus preventing multiple organ dysfunction syndrome. In this review we trend the journey of these drugs, how high hopes were pinned to their use but they failed to show any mortality benefit in hospitalized patients. However, still certain studies are underway to explore their role in prophylaxis or otherwise. Medline, Medscape, EMBASE, Cochrane database, Scopus and clinicaltrials.gov were searched using terms like “SARS-CoV-2”, “COVID-19”, “Chloroquine” and “Hydroxychloroquine”.
{"title":"Journey of Chloroquine/ Hydroxychloroquine in the management of COVID-19","authors":"K. Sekhri, S. Bhanwra, R. Nandha, S. Aditya, Deepak Bhasin","doi":"10.52711/2321-5836.2022.00019","DOIUrl":"https://doi.org/10.52711/2321-5836.2022.00019","url":null,"abstract":"Chloroquine was discovered in 1934 and since then it is used as an antimalarial drug saving millions of lives. Chloroquine and its analogue Hydroxychloroquine possess pleotropic pharmacological actions and are of proven value in multiple conditions ranging from protozoal to autoimmune diseases. Advantage with these drugs is their well-documented tolerability profile. In Severe Acute Respiratory Syndrome Corona virus-2 (SARS-CoV-2), these drugs in vitro showed promising results working at multiple sites ranging from prevention of entry of the virus into human cells, halting the multiplication by altering the pH of internal organelles towards basic side and via exocytosis. These drugs also act as immunomodulators to prevent flare up of cytokines and interleukin cascade, thus preventing multiple organ dysfunction syndrome. In this review we trend the journey of these drugs, how high hopes were pinned to their use but they failed to show any mortality benefit in hospitalized patients. However, still certain studies are underway to explore their role in prophylaxis or otherwise. Medline, Medscape, EMBASE, Cochrane database, Scopus and clinicaltrials.gov were searched using terms like “SARS-CoV-2”, “COVID-19”, “Chloroquine” and “Hydroxychloroquine”.","PeriodicalId":20945,"journal":{"name":"Research Journal of Pharmacology and Pharmacodynamics","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79078946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-29DOI: 10.52711/2321-5836.2022.00013
Gaikwad Adarsh, Patil Rutuja
Zika virus is as similar ass dengue and yellow fever. This virus is from family Flaviviridae.This virus can cause human infection in Asia and Africa. Zika virus is characterized by subclinical or mild influenza like illness. In Guillain –Barre syndrome, there are found 2 to 3 patients of zika virus per 10000. Scientific name of Zika virus is a Flavivirus. (1)
{"title":"Zika Virus and its Pathogenesis and its Treatment","authors":"Gaikwad Adarsh, Patil Rutuja","doi":"10.52711/2321-5836.2022.00013","DOIUrl":"https://doi.org/10.52711/2321-5836.2022.00013","url":null,"abstract":"Zika virus is as similar ass dengue and yellow fever. This virus is from family Flaviviridae.This virus can cause human infection in Asia and Africa. Zika virus is characterized by subclinical or mild influenza like illness. In Guillain –Barre syndrome, there are found 2 to 3 patients of zika virus per 10000. Scientific name of Zika virus is a Flavivirus. (1)","PeriodicalId":20945,"journal":{"name":"Research Journal of Pharmacology and Pharmacodynamics","volume":"151 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86163147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The baobab tree, Adansonia digitata L. (Malvaceae), is a native of Africa. Baobab is a multipurpose tree that provides protection food, clothes and medicine, as well as raw materials for a verity of products. Baobab’s fruits pulp, seeds, leaves, flowers, roots and bark are edible and it is qualities have been researched by scientists. The fruit pulp has the large amount of vitamin C, calcium, Phosphate, crabs, fibers, potassium, proteins and lipids can be used an appetizer or drink. Seeds are high in lysin, thiamine, calcium and iron and include significant amount of phosphorous, magnesium, zinc, sodium, iron, and manganese. Antimicrobial, antimalarial, diarrhea, anemia, asthma, antiviral, antioxidant, and anti-inflammatory characteristics are only a few of the biological qualities of baobab. Flavonoids, phytosterols, amino acids, fatty acid, vitamins and minerals were discovered by phytochemical analysis.
猴面包树，Adansonia digitata L. (malvacae)，是非洲的原生植物。猴面包树是一种多用途的树木，它提供保护食品，衣服和药物，以及各种产品的原料。猴面包树的果实、果肉、种子、叶子、花、根和树皮都是可食用的，科学家们已经对其品质进行了研究。果肉中含有大量的维生素C、钙、磷酸盐、蟹蟹、纤维、钾、蛋白质和脂质，可用作开胃菜或饮料。种子富含溶酶素、硫胺素、钙和铁，还含有大量的磷、镁、锌、钠、铁和锰。抗菌、抗疟疾、腹泻、贫血、哮喘、抗病毒、抗氧化和抗炎特性只是猴面包树的部分生物学特性。通过植物化学分析发现了黄酮类化合物、植物甾醇、氨基酸、脂肪酸、维生素和矿物质。
{"title":"The Various Pharmacological Activity of Adansonia digitata","authors":"Harshit Rana, R. Kumar, Aarti Chopra, Sweta Pundir, Girendra Kumar Gautam, Gautam Kumar","doi":"10.52711/2321-5836.2022.00009","DOIUrl":"https://doi.org/10.52711/2321-5836.2022.00009","url":null,"abstract":"The baobab tree, Adansonia digitata L. (Malvaceae), is a native of Africa. Baobab is a multipurpose tree that provides protection food, clothes and medicine, as well as raw materials for a verity of products. Baobab’s fruits pulp, seeds, leaves, flowers, roots and bark are edible and it is qualities have been researched by scientists. The fruit pulp has the large amount of vitamin C, calcium, Phosphate, crabs, fibers, potassium, proteins and lipids can be used an appetizer or drink. Seeds are high in lysin, thiamine, calcium and iron and include significant amount of phosphorous, magnesium, zinc, sodium, iron, and manganese. Antimicrobial, antimalarial, diarrhea, anemia, asthma, antiviral, antioxidant, and anti-inflammatory characteristics are only a few of the biological qualities of baobab. Flavonoids, phytosterols, amino acids, fatty acid, vitamins and minerals were discovered by phytochemical analysis.","PeriodicalId":20945,"journal":{"name":"Research Journal of Pharmacology and Pharmacodynamics","volume":"235 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80233724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-05DOI: 10.52711/2321-5836.2022.00003
P. Minesh
Technology plays a crucial role now on each day within the event of science similarly as within the medical sciences including within the event of the pharmaceutical process lifestyle. This technology will simplify the work and increased not productivity and also quality. engineering is that the science of mimicking human mental faculties in a very computer. the ultimate word achievement during this field would be to construct a machine that will mimic or exceed human mental capabilities, including reasoning, understanding, imagination, perception, recognition, creativity, and emotions. We are a protracted way from achieving this, but some significant successes have nevertheless been achieved. dementedness (AD) may well be a neurodegenerative disease characterized by a progressive exacerbation of dementia; finally, patients lose the pliability to reply to their environment. aside from cholinesterase inhibitors and memantine, which can alleviate or stabilize symptoms for a limited time, there are currently no because of stopping the progression of Alzheimer's.
{"title":"A Review on Importance of Artificial Intelligence in Alzheimer’s Disease and it’s Future Outcomes for Alzheimer’s Disease","authors":"P. Minesh","doi":"10.52711/2321-5836.2022.00003","DOIUrl":"https://doi.org/10.52711/2321-5836.2022.00003","url":null,"abstract":"Technology plays a crucial role now on each day within the event of science similarly as within the medical sciences including within the event of the pharmaceutical process lifestyle. This technology will simplify the work and increased not productivity and also quality. engineering is that the science of mimicking human mental faculties in a very computer. the ultimate word achievement during this field would be to construct a machine that will mimic or exceed human mental capabilities, including reasoning, understanding, imagination, perception, recognition, creativity, and emotions. We are a protracted way from achieving this, but some significant successes have nevertheless been achieved. dementedness (AD) may well be a neurodegenerative disease characterized by a progressive exacerbation of dementia; finally, patients lose the pliability to reply to their environment. aside from cholinesterase inhibitors and memantine, which can alleviate or stabilize symptoms for a limited time, there are currently no because of stopping the progression of Alzheimer's.","PeriodicalId":20945,"journal":{"name":"Research Journal of Pharmacology and Pharmacodynamics","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85380806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-05DOI: 10.52711/2321-5836.2022.00007
S. D. Mankar, S. Bhawar, Mohini R. Shelke, Pankaj Sonawane, Shraddha Parjane
The Asteraceae family's chamomile (Matricaria chamomilla L.) may be a well-known medicinal plant. Chamaemelum nobile, also referred to as Roman chamomile, is usually referred to as real chamomile or sweet false chamomile. Effect of sweet false chamomile extract on linearincisional wound healing was studied. The article briefly review on the medicinal and cosmetic benefits of matricaria. The major medicinal uses of this plant is antiinflammatory, antidiarrheal, antacid. chamoline as an cosmetic ingredient is good for skin and hair. Mouthwashes and tooth pase also contain chamomile as an ingredient. Chamomile also have antioxidant property. It treat gastrointestinal problem by acting as purgative and also use to treat acidity. It promotes wound healing effect in the case of cradle and bunions. The flavonoids apigenin, luteolin, quercetin, patuletin, and volatile oil compounds like bisabolol and its oxides, also as azulenes, are liable for chamomile's biological action. There are several chamomile chemocultivars. Chamomile is anti-inflammatory, deodorant, antibacterial, carminative, sedative, antiseptic, anticatarrhal, and spasmolytic.
{"title":"Thyroid Disorder: An Overview","authors":"S. D. Mankar, S. Bhawar, Mohini R. Shelke, Pankaj Sonawane, Shraddha Parjane","doi":"10.52711/2321-5836.2022.00007","DOIUrl":"https://doi.org/10.52711/2321-5836.2022.00007","url":null,"abstract":"The Asteraceae family's chamomile (Matricaria chamomilla L.) may be a well-known medicinal plant. Chamaemelum nobile, also referred to as Roman chamomile, is usually referred to as real chamomile or sweet false chamomile. Effect of sweet false chamomile extract on linearincisional wound healing was studied. The article briefly review on the medicinal and cosmetic benefits of matricaria. The major medicinal uses of this plant is antiinflammatory, antidiarrheal, antacid. chamoline as an cosmetic ingredient is good for skin and hair. Mouthwashes and tooth pase also contain chamomile as an ingredient. Chamomile also have antioxidant property. It treat gastrointestinal problem by acting as purgative and also use to treat acidity. It promotes wound healing effect in the case of cradle and bunions. The flavonoids apigenin, luteolin, quercetin, patuletin, and volatile oil compounds like bisabolol and its oxides, also as azulenes, are liable for chamomile's biological action. There are several chamomile chemocultivars. Chamomile is anti-inflammatory, deodorant, antibacterial, carminative, sedative, antiseptic, anticatarrhal, and spasmolytic.","PeriodicalId":20945,"journal":{"name":"Research Journal of Pharmacology and Pharmacodynamics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87236552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-05DOI: 10.52711/2321-5836.2022.00002
Ganesh G. Dhakad, G. D. Patil, Ashwini C. Nikum, Sangita P. Shirsat
At high doses, radiation therapy kills cancer cells or slows their growth by damaging their DNA. Cancer cells whose DNA is damaged beyond repair stop dividing or die. When the damaged cells die, they are broken down and removed by the body.Radiation therapy does not kill cancer cells right away. It takes days or weeks of treatment before DNA is damaged enough for cancer cells to die. Then, cancer cells keep dying for weeks or months after radiation therapy ends. Radiation therapy is used to treat cancer and ease cancer symptoms. When used to treat cancer, radiation therapy can cure cancer, prevent it from returning, or stop or slow its growth.When treatments are used to ease symptoms, they are known as palliative treatments. External beam radiation may shrink tumors to treat pain and other problems caused by the tumor, such as trouble breathing or loss of bowel and bladder control. Pain from cancer that has spread to the bone can be treated with systemic radiation therapy drugs called radiopharmaceuticals.
{"title":"Review on Radiation Therapy on Cancer","authors":"Ganesh G. Dhakad, G. D. Patil, Ashwini C. Nikum, Sangita P. Shirsat","doi":"10.52711/2321-5836.2022.00002","DOIUrl":"https://doi.org/10.52711/2321-5836.2022.00002","url":null,"abstract":"At high doses, radiation therapy kills cancer cells or slows their growth by damaging their DNA. Cancer cells whose DNA is damaged beyond repair stop dividing or die. When the damaged cells die, they are broken down and removed by the body.Radiation therapy does not kill cancer cells right away. It takes days or weeks of treatment before DNA is damaged enough for cancer cells to die. Then, cancer cells keep dying for weeks or months after radiation therapy ends. Radiation therapy is used to treat cancer and ease cancer symptoms. When used to treat cancer, radiation therapy can cure cancer, prevent it from returning, or stop or slow its growth.When treatments are used to ease symptoms, they are known as palliative treatments. External beam radiation may shrink tumors to treat pain and other problems caused by the tumor, such as trouble breathing or loss of bowel and bladder control. Pain from cancer that has spread to the bone can be treated with systemic radiation therapy drugs called radiopharmaceuticals.","PeriodicalId":20945,"journal":{"name":"Research Journal of Pharmacology and Pharmacodynamics","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76792129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-05DOI: 10.52711/2321-5836.2022.00004
S. Shankar, G. P, Roja E.
Herbs and spices are not just useful to us as flavouring agents but they are actually nature's way to treat dental infections also. Several dental problems like tooth ache, caries, etc have become very common among the human population across the globe. These are mainly due to the action of microorganisms like Streptococcus mutans, Streptococcus sobrinus, lactobacilli, etc. Such problems can actually be cured naturally by using herbs and spices like cloves, thyme, peppermint leaves, goldenseal, green tea, etc which contain particular substances (that are found in dental medicines), which act against the microorganisms causing dental problems by either killing them or inhibiting their growth, are used to treat these problems. Apart from the above use, it is also effective in cases of infections where allopathic medications have no or minimal actions which may be due to the increased resistance exhibited by the pathogens to particular allopathic medications, some antibacterial agents currently used in dentistry produces adverse-affects like nausea, vomiting, diarrhoea, headache, staining of teeth, etc. and financial considerations in relation to allopathic medications in developing countries creates a need for alternative prevention and treatment options that are safe, effective and economical. Hence, the search for alternative products continues and herbs and spices that were used as traditional medicines in the ancient times are considered as good alternatives. Therefore, understanding the role of herbs and spices in controlling dental infection scan help people to cure and prevent these infections in a natural way and help them overcome all the above problems.
{"title":"Role of Spices and Herbs in Controlling Dental Problems","authors":"S. Shankar, G. P, Roja E.","doi":"10.52711/2321-5836.2022.00004","DOIUrl":"https://doi.org/10.52711/2321-5836.2022.00004","url":null,"abstract":"Herbs and spices are not just useful to us as flavouring agents but they are actually nature's way to treat dental infections also. Several dental problems like tooth ache, caries, etc have become very common among the human population across the globe. These are mainly due to the action of microorganisms like Streptococcus mutans, Streptococcus sobrinus, lactobacilli, etc. Such problems can actually be cured naturally by using herbs and spices like cloves, thyme, peppermint leaves, goldenseal, green tea, etc which contain particular substances (that are found in dental medicines), which act against the microorganisms causing dental problems by either killing them or inhibiting their growth, are used to treat these problems. Apart from the above use, it is also effective in cases of infections where allopathic medications have no or minimal actions which may be due to the increased resistance exhibited by the pathogens to particular allopathic medications, some antibacterial agents currently used in dentistry produces adverse-affects like nausea, vomiting, diarrhoea, headache, staining of teeth, etc. and financial considerations in relation to allopathic medications in developing countries creates a need for alternative prevention and treatment options that are safe, effective and economical. Hence, the search for alternative products continues and herbs and spices that were used as traditional medicines in the ancient times are considered as good alternatives. Therefore, understanding the role of herbs and spices in controlling dental infection scan help people to cure and prevent these infections in a natural way and help them overcome all the above problems.","PeriodicalId":20945,"journal":{"name":"Research Journal of Pharmacology and Pharmacodynamics","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75162626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-05DOI: 10.52711/2321-5836.2022.00005
G. Sahu, A. Chandy, Raju Sahu
Delivering a drug to eye has been a major challenge to pharmacologists and drug delivery scientists (Gaudana et al 2010). It is due to its complex structure and unique anatomy and physiology. This results only small portion of drug reaches to the site of action. The eye contains two main chambers, anterior chamber and posterior chamber (Chen et al., 2018). As the renewal time of tear fluid is less than 5 minutes (Mishima, Gusset et al., 1996) ophthalmic drug washout very quickly from anterior portion of cornea. To prevail over with this issue various formulations strategies have been investigated to increase ocular drug retention. In ophthalmic formulations the suspension is better option for incorporating poorly soluble active pharmaceutical ingredients. As ophthalmic suspension improvise drug delivery by enhancing retention time of drug, thereby increasing the bioavailability of the drug. In this review we will discuss about the important parameters that are considered in the formulation of ophthalmic suspension.
将药物输送到眼睛一直是药理学家和药物输送科学家面临的主要挑战(Gaudana et al . 2010)。这是由于其复杂的结构和独特的解剖学和生理学。这导致只有一小部分药物到达作用部位。眼睛包含两个主要腔室，前房和后房(Chen et al.， 2018)。由于泪液更新时间小于5分钟(Mishima, Gusset et al.， 1996)，眼药从角膜前部冲洗非常快。为了克服这个问题，人们研究了各种配方策略来增加眼部药物潴留。在眼科制剂中，混悬液是纳入难溶活性药物成分的较好选择。眼用悬浮液通过延长药物的滞留时间来改善给药效果，从而提高药物的生物利用度。在这篇综述中，我们将讨论在配制眼用悬浮液时需要考虑的重要参数。
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