Pub Date : 2022-11-12DOI: 10.52711/0975-4377.2022.00046
Shikha Baghel Chauhan, Sakshi Nainwani
Telmisartan is one of the best options either in combination or alone, to treat hypertension. telmisartan belongs to class II antagonist angiotensin converting enzyme inhibitor. One of the main causes of hypertension is vasoconstriction of blood vessels hence increasing blood pressure which can be controlled by drugs that have vasoconstriction property and telmisartan is one of them, and it also relaxes the blood vessels. The dosage form opted here is floating microspheres as it can provide sustain release of drug over long period of time. Floating microspheres have a tendency to float over gastric fluid hence increasing gastric retention time. These are preferred over conventional form as they provide advantage of reducing gastric irritation, lesser dosing frequency will be required as it provide slow continuous release for prolong period of time. The present research aims to formulate telmisartan floating microspheres and its evaluation. The technique used is solvent evaporation method by using magnetic stirrer. Already formulated telmisartan microspheres have lower bioavailability, drug entrapment and lower release kinetics so our main aim is to formulate such a preparation which have greater bioavailability, drug entrapment and greater kinetic release, and to formulate such a formulation we have opted using variant ratios of polymer Eudragit RS 100, Ethyl Cellulose with constant dose of drug. After formulation, various characterization is done that include micromeritics properties, floating efficiency, solubility, drug entrapment efficiency along with yield and release kinetics. The study revealed that, using a more than one polymer in a different ratio have an impact on every parameter of microspheres.
{"title":"Formulation and Evaluation of Floating Microspheres for an Antihypertensive drug Telmisartan","authors":"Shikha Baghel Chauhan, Sakshi Nainwani","doi":"10.52711/0975-4377.2022.00046","DOIUrl":"https://doi.org/10.52711/0975-4377.2022.00046","url":null,"abstract":"Telmisartan is one of the best options either in combination or alone, to treat hypertension. telmisartan belongs to class II antagonist angiotensin converting enzyme inhibitor. One of the main causes of hypertension is vasoconstriction of blood vessels hence increasing blood pressure which can be controlled by drugs that have vasoconstriction property and telmisartan is one of them, and it also relaxes the blood vessels. The dosage form opted here is floating microspheres as it can provide sustain release of drug over long period of time. Floating microspheres have a tendency to float over gastric fluid hence increasing gastric retention time. These are preferred over conventional form as they provide advantage of reducing gastric irritation, lesser dosing frequency will be required as it provide slow continuous release for prolong period of time. The present research aims to formulate telmisartan floating microspheres and its evaluation. The technique used is solvent evaporation method by using magnetic stirrer. Already formulated telmisartan microspheres have lower bioavailability, drug entrapment and lower release kinetics so our main aim is to formulate such a preparation which have greater bioavailability, drug entrapment and greater kinetic release, and to formulate such a formulation we have opted using variant ratios of polymer Eudragit RS 100, Ethyl Cellulose with constant dose of drug. After formulation, various characterization is done that include micromeritics properties, floating efficiency, solubility, drug entrapment efficiency along with yield and release kinetics. The study revealed that, using a more than one polymer in a different ratio have an impact on every parameter of microspheres.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87251587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-12DOI: 10.52711/0975-4377.2022.00047
M. V. Ramana, V. Sowmya, K. Sangeetha, K. Nagapreethi, M. Mounika, S. Divya, A. Kanakalaxmi
Literature survey reveals that few spectrophotometric, high performance liquid chromatographic (HPLC)and High performance thin layer chromatographic (HPTLC)methods were reported for the estimation of Amlodipine and perindopril in bulk and combined pharmaceutical dosage forms. But there is no any stability indicating high performance liquid chromatography study is reported for amlodipine. So the present study was aimed to development of simple, accurate, rapid and economical HPLC stability indicating assay method were established for the determination of Amlodipine and Peridopril in bulk and tablet dosage form. A High-performance liquid chromatograph WATERS, software: Empower 2,2695 separation module, 996 PDA detector, using Phenomenex Luna C18 (4.6mm×250mm) 5µm or equivalent column, with mobile phase composition of Methanol: Phosphate Buffer pH3.0 (70:30v/v) was used. The flow rate of 1.0ml min-1 and effluent was detected at 230nm. The retention time of Amlodipine and Perindopril was found to be 1.870min and 2.499minutes respectively. Linearity was observed over concentration range of 10-50µg ml-1 for Amlodipine and 16-80µg ml-1 for Perindopril respectively. The accuracy of the proposed method was determined by recovery studies and the Amlodipine was found to be 99.1% and Perindopril was found to be 98.8% respectively. The proposed method is applicable to routine analysis of Amlodipine and Perindopril in bulk and pharmaceutical formulations. The proposed method was validated for various ICH parameters like linearity, limit of detection, limits of quantification, accuracy, precision, range and specificity.
{"title":"Method Development and Validation for the estimation of Amlodipine and Perindopril in Bulk and Pharmaceutical Dosage Form","authors":"M. V. Ramana, V. Sowmya, K. Sangeetha, K. Nagapreethi, M. Mounika, S. Divya, A. Kanakalaxmi","doi":"10.52711/0975-4377.2022.00047","DOIUrl":"https://doi.org/10.52711/0975-4377.2022.00047","url":null,"abstract":"Literature survey reveals that few spectrophotometric, high performance liquid chromatographic (HPLC)and High performance thin layer chromatographic (HPTLC)methods were reported for the estimation of Amlodipine and perindopril in bulk and combined pharmaceutical dosage forms. But there is no any stability indicating high performance liquid chromatography study is reported for amlodipine. So the present study was aimed to development of simple, accurate, rapid and economical HPLC stability indicating assay method were established for the determination of Amlodipine and Peridopril in bulk and tablet dosage form. A High-performance liquid chromatograph WATERS, software: Empower 2,2695 separation module, 996 PDA detector, using Phenomenex Luna C18 (4.6mm×250mm) 5µm or equivalent column, with mobile phase composition of Methanol: Phosphate Buffer pH3.0 (70:30v/v) was used. The flow rate of 1.0ml min-1 and effluent was detected at 230nm. The retention time of Amlodipine and Perindopril was found to be 1.870min and 2.499minutes respectively. Linearity was observed over concentration range of 10-50µg ml-1 for Amlodipine and 16-80µg ml-1 for Perindopril respectively. The accuracy of the proposed method was determined by recovery studies and the Amlodipine was found to be 99.1% and Perindopril was found to be 98.8% respectively. The proposed method is applicable to routine analysis of Amlodipine and Perindopril in bulk and pharmaceutical formulations. The proposed method was validated for various ICH parameters like linearity, limit of detection, limits of quantification, accuracy, precision, range and specificity.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81402524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-12DOI: 10.52711/0975-4377.2022.00054
Pankaj. P. Sathe, Kedar Bavaskar, Ashish Jain
The goal of this review on floating drug delivery systems (FDDS) was to compile latest data with a particular focus on the main mechanism of flotation for stomach retention. Drug delivery systems that float instantly when they come into contact with gastric fluids are promising approaches for increasing the bioavailability of drugs within absorption window in the stomach or upper small intestine. They are unstable in the intestinal or colonic environment and have low solubility at high pH values. The Current pharmaceutical scenario focuses on the development of sustained drug delivery systems to achieve required therapeutic concentration with less amount of dose. Oral delivery of the drug is the preferable drug delivery system. Because of the ease of administration, patient compliance and formulation flexibility. The ability to delay and control the emptying period of a dosage form in the stomach is an extremely variable process. For dosage forms that stay in the stomach for longer periods of time than standard dosage forms so the gastric transit time is a valuable asset for this system. The goal of this review article is to provide detailed information on the pharmaceutical basis of their design, classification, advantages, in vitro and in vivo evaluation parameters, and applications of floating systems. These systems can help with a variety of issues that arise during the development of a pharmaceutical dosage form, as well as the potential of FDDS in the future. This review article makes an attempt to introduce readers to current developments in floating drug delivery systems.
{"title":"Floating Drug Delivery System: A Novel apporach for Delivery of Drug on Targated Organ","authors":"Pankaj. P. Sathe, Kedar Bavaskar, Ashish Jain","doi":"10.52711/0975-4377.2022.00054","DOIUrl":"https://doi.org/10.52711/0975-4377.2022.00054","url":null,"abstract":"The goal of this review on floating drug delivery systems (FDDS) was to compile latest data with a particular focus on the main mechanism of flotation for stomach retention. Drug delivery systems that float instantly when they come into contact with gastric fluids are promising approaches for increasing the bioavailability of drugs within absorption window in the stomach or upper small intestine. They are unstable in the intestinal or colonic environment and have low solubility at high pH values. The Current pharmaceutical scenario focuses on the development of sustained drug delivery systems to achieve required therapeutic concentration with less amount of dose. Oral delivery of the drug is the preferable drug delivery system. Because of the ease of administration, patient compliance and formulation flexibility. The ability to delay and control the emptying period of a dosage form in the stomach is an extremely variable process. For dosage forms that stay in the stomach for longer periods of time than standard dosage forms so the gastric transit time is a valuable asset for this system. The goal of this review article is to provide detailed information on the pharmaceutical basis of their design, classification, advantages, in vitro and in vivo evaluation parameters, and applications of floating systems. These systems can help with a variety of issues that arise during the development of a pharmaceutical dosage form, as well as the potential of FDDS in the future. This review article makes an attempt to introduce readers to current developments in floating drug delivery systems.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":"16 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89790657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-12DOI: 10.52711/0975-4377.2022.00042
Priti B. Savant, Shrikrushna A. Shinde, Jayamala S. Barge
Microencapsulation is a process in which tiny particles or droplets are surrounded by a coating to give small capsules, with useful properties. Microcapsule is a small sphere with uniform wall around it. The material inside the microcapsule is referred to as the core, internal phase or fill, whereas the wall sometimes called as shell, coating or membrane. Microencapsulation is a rapidly expanding technology in which very tiny droplets or particles of liquid or solid material are surrounded or coated with a continuous film of polymeric material. Aspirin (Acetylsalicylic acid) is a Non steroidal anti-inflammatory drug. It inhibits platelets aggregation and prolong bleeding time. This research article will emphasize formulation and evaluation of microcapsules of aspirin by coacervation phase separation method. coacervation phase separation techanique have been widely used to incorporate drugs into polymeric microcapsules.
{"title":"Formulation and Evaluation of Microcapsules of Aspirin by Coacervation Phase Separation Method","authors":"Priti B. Savant, Shrikrushna A. Shinde, Jayamala S. Barge","doi":"10.52711/0975-4377.2022.00042","DOIUrl":"https://doi.org/10.52711/0975-4377.2022.00042","url":null,"abstract":"Microencapsulation is a process in which tiny particles or droplets are surrounded by a coating to give small capsules, with useful properties. Microcapsule is a small sphere with uniform wall around it. The material inside the microcapsule is referred to as the core, internal phase or fill, whereas the wall sometimes called as shell, coating or membrane. Microencapsulation is a rapidly expanding technology in which very tiny droplets or particles of liquid or solid material are surrounded or coated with a continuous film of polymeric material. Aspirin (Acetylsalicylic acid) is a Non steroidal anti-inflammatory drug. It inhibits platelets aggregation and prolong bleeding time. This research article will emphasize formulation and evaluation of microcapsules of aspirin by coacervation phase separation method. coacervation phase separation techanique have been widely used to incorporate drugs into polymeric microcapsules.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":"74 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83787264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Orally directed medications totally ingest just when they show reasonable dissolvability in gastric medium and such medications shows great bioavailability. The solvency and disintegration properties of medications assume a significant part during the formulation development. Greater part of the disappointments in the new medication improvement have been credited to poor water dissolvability of medication. It is widely accepted that poor water dissolvability is quite possibly the most every now and again experienced troubles in the field of pharmaceutics. Low solvency and ensuing unacceptable disintegration rate regularly bargain oral bioavailability. There are most remedial specialists used to create fundamental impacts by oral course that are the favored method of organization inferable from its few benefits and high quiet consistence contrasted with different courses. Thusly the current methodologies being utilized for BCS class II medications, along with retention enhancers, can be applied to detail class IV compound. Effervescent Assisted Fusion Technique, Solvent Evaporation method, Microemulsion, Liposomes are some imperative methodologies regularly utilized to improve the dissolvability of ineffectively water dissolvable medications. Determination of technique for solvency upgrade relies on drug qualities like dissolvability, substance nature, melting point, retention site, actual nature, pharmacokinetic conduct, etc, measurement structure necessity like tablet or capsule formulation, strength, quick or modified release. This review features the novel strategies accessible for improving solvency, disintegration and bioavailability of medications with poor fluid dissolvability.
{"title":"Methods for Improving the Solubility of Water-Insoluble Drugs: A Comprehensive Review","authors":"Wajid Ahmad, Rihan Sheikh, Razia Ahmad, Suhana Khan","doi":"10.52711/0975-4377.2022.00051","DOIUrl":"https://doi.org/10.52711/0975-4377.2022.00051","url":null,"abstract":"Orally directed medications totally ingest just when they show reasonable dissolvability in gastric medium and such medications shows great bioavailability. The solvency and disintegration properties of medications assume a significant part during the formulation development. Greater part of the disappointments in the new medication improvement have been credited to poor water dissolvability of medication. It is widely accepted that poor water dissolvability is quite possibly the most every now and again experienced troubles in the field of pharmaceutics. Low solvency and ensuing unacceptable disintegration rate regularly bargain oral bioavailability. There are most remedial specialists used to create fundamental impacts by oral course that are the favored method of organization inferable from its few benefits and high quiet consistence contrasted with different courses. Thusly the current methodologies being utilized for BCS class II medications, along with retention enhancers, can be applied to detail class IV compound. Effervescent Assisted Fusion Technique, Solvent Evaporation method, Microemulsion, Liposomes are some imperative methodologies regularly utilized to improve the dissolvability of ineffectively water dissolvable medications. Determination of technique for solvency upgrade relies on drug qualities like dissolvability, substance nature, melting point, retention site, actual nature, pharmacokinetic conduct, etc, measurement structure necessity like tablet or capsule formulation, strength, quick or modified release. This review features the novel strategies accessible for improving solvency, disintegration and bioavailability of medications with poor fluid dissolvability.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78475143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rifaximin treats traveler's diarrhea and irritable bowel syndrome by stopping the growth of the bacteria that cause diarrhea. Rifaximin treats hepatic encephalopathy by stopping the growth of bacteria that produce toxins and that may worsen liver disease. The short half life and high frequency of administration of drug makes it a suitable candidate for designing sustained drug delivery system. The aim of the present investigation was to develop a sustained release matrix tablet of Rifaximin using sodium alginate and cross linked sodium alginate and to evaluate the drug release kinetics. In order to achieve the required sustained release profile, the tablets were prepared by a wet granulation method. The formulated tablets were characterized for pre-compression and post-compression parameters and they were in the acceptable limits. The drug release data obtained after an in vitro dissolution study was fitted to various release kinetic models in order to evaluate the release mechanism and kinetics. The criterion for selecting the best fit model was linearity (coefficient of correlation). Drug release mechanism was found to follow a complex mixture of diffusion, swelling and erosion. The dosage form holds the potential to control the release rate of drug and extend the duration of action of a drug.
{"title":"Preparation and Evaluation of Sustained Release Tablet of Rifaximin by using Cross linked Sodium Alginate","authors":"Wajid Ahmad, Rihan Sheikh, Razia Ahmad, Suhana Khan","doi":"10.52711/0975-4377.2022.00043","DOIUrl":"https://doi.org/10.52711/0975-4377.2022.00043","url":null,"abstract":"Rifaximin treats traveler's diarrhea and irritable bowel syndrome by stopping the growth of the bacteria that cause diarrhea. Rifaximin treats hepatic encephalopathy by stopping the growth of bacteria that produce toxins and that may worsen liver disease. The short half life and high frequency of administration of drug makes it a suitable candidate for designing sustained drug delivery system. The aim of the present investigation was to develop a sustained release matrix tablet of Rifaximin using sodium alginate and cross linked sodium alginate and to evaluate the drug release kinetics. In order to achieve the required sustained release profile, the tablets were prepared by a wet granulation method. The formulated tablets were characterized for pre-compression and post-compression parameters and they were in the acceptable limits. The drug release data obtained after an in vitro dissolution study was fitted to various release kinetic models in order to evaluate the release mechanism and kinetics. The criterion for selecting the best fit model was linearity (coefficient of correlation). Drug release mechanism was found to follow a complex mixture of diffusion, swelling and erosion. The dosage form holds the potential to control the release rate of drug and extend the duration of action of a drug.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":"2013 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72613022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-12DOI: 10.52711/0975-4377.2022.00056
Wajid Ahmad, Jaza Quazi
This review assesses the use of Calendula officinalis extract in antihyperlipidemic activities, cardiovascular activities, antidiabetic, hepatoprotective activities; anthelmintic activities; antioxidant activities; anti-inflammatory activities; wound healing activities; anticancer activities; hepatoprotective activities, antibacterial activities; and anti-HIV activities. C. officinalis extract has been shown to have some remedial effects and has been used in herbal remedies, according to this review. To examine the effect of calendula officinalis, larger as well as well-designed random control trials are needed. Calendula officinalis is a flowering plant that comes under the Asteraceae family. This herb is used as curative in Europe, China, and India. It's been the subject of a number of chemical and pharmacological research, and it's also known as "African marigold." It's commonly utilized in indigenous medicine to treat jaundice, wound recovery, plasma cleansing, and spasmolytic treatment. A vast range of chemicals, including amino acids, triterpenoids, coumarines, quinones, flavonoids, volatile oils, and carotenoids, have been found through chemical analysis.
{"title":"A Review that on Emphasizes the Traditional uses and Clinical Potential Calendula officinalis","authors":"Wajid Ahmad, Jaza Quazi","doi":"10.52711/0975-4377.2022.00056","DOIUrl":"https://doi.org/10.52711/0975-4377.2022.00056","url":null,"abstract":"This review assesses the use of Calendula officinalis extract in antihyperlipidemic activities, cardiovascular activities, antidiabetic, hepatoprotective activities; anthelmintic activities; antioxidant activities; anti-inflammatory activities; wound healing activities; anticancer activities; hepatoprotective activities, antibacterial activities; and anti-HIV activities. C. officinalis extract has been shown to have some remedial effects and has been used in herbal remedies, according to this review. To examine the effect of calendula officinalis, larger as well as well-designed random control trials are needed. Calendula officinalis is a flowering plant that comes under the Asteraceae family. This herb is used as curative in Europe, China, and India. It's been the subject of a number of chemical and pharmacological research, and it's also known as \"African marigold.\" It's commonly utilized in indigenous medicine to treat jaundice, wound recovery, plasma cleansing, and spasmolytic treatment. A vast range of chemicals, including amino acids, triterpenoids, coumarines, quinones, flavonoids, volatile oils, and carotenoids, have been found through chemical analysis.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":"125 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77976937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-12DOI: 10.52711/0975-4377.2022.00048
M. Tawar, Kiran H. Raut, Reshma Chaudhary, N. Jain
The basic reason behind this study was to enhance the solubility rate of resveratrol which will finally enhance the dissolution i.e. the rate of drug release due to which the absorption of the drug will increase. The method applied here was effervescent assisted fusion technique. Various batches were prepared by employing water soluble carrier and sodium bicarbonate. The results obtained from the study revealed that the solubility of the drug can be increased up to 10 times than compared with the pure drug in various solvents i.e. phosphate buffer and distilled water. The compatibility study showed no interaction between drug and the excipient while the micromeretics property showed good flow property with good compressibility property. The percent yield of the dispersions prepared ranges between 79.20±0.28% - 89.38±0.25% while the drug release data showed a better rate of drug release than compared with the pure drug which ranges between 10.87% - 99.14%. The pure drug was having a drug release of less than 70% while the optimized batch F5 was having a drug release of more than 95% in the specific period of time. The XRD data showed that the drug’s crystalline structure was not hampered during the preparation while the SEM data revealed the surface shape of the pure drug which was tile shaped and the prepared dispersion was of flakes like formation. From the study it can be concluded that the methods employed in this study can be proven to be a excellent method for enhancing the solubility of the drug up to 10 folds.
{"title":"Solubility Enhancement of Resveratrol by Effervescence Assisted Fusion Technique","authors":"M. Tawar, Kiran H. Raut, Reshma Chaudhary, N. Jain","doi":"10.52711/0975-4377.2022.00048","DOIUrl":"https://doi.org/10.52711/0975-4377.2022.00048","url":null,"abstract":"The basic reason behind this study was to enhance the solubility rate of resveratrol which will finally enhance the dissolution i.e. the rate of drug release due to which the absorption of the drug will increase. The method applied here was effervescent assisted fusion technique. Various batches were prepared by employing water soluble carrier and sodium bicarbonate. The results obtained from the study revealed that the solubility of the drug can be increased up to 10 times than compared with the pure drug in various solvents i.e. phosphate buffer and distilled water. The compatibility study showed no interaction between drug and the excipient while the micromeretics property showed good flow property with good compressibility property. The percent yield of the dispersions prepared ranges between 79.20±0.28% - 89.38±0.25% while the drug release data showed a better rate of drug release than compared with the pure drug which ranges between 10.87% - 99.14%. The pure drug was having a drug release of less than 70% while the optimized batch F5 was having a drug release of more than 95% in the specific period of time. The XRD data showed that the drug’s crystalline structure was not hampered during the preparation while the SEM data revealed the surface shape of the pure drug which was tile shaped and the prepared dispersion was of flakes like formation. From the study it can be concluded that the methods employed in this study can be proven to be a excellent method for enhancing the solubility of the drug up to 10 folds.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86029262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-12DOI: 10.52711/0975-4377.2022.00044
Sheeba Fr, Amar Sahani, Yogesh Db
Aim: This study is aimed to prepare floating matrix Domperidone Maleate tablets by using natural polymers. Materials and Methods: Domperidone maleate was formulated as floating matrix tablets to increase the gastric residence time. Natural polymers like xanthan gum, tragacanth, sodium alginate along with sodium bicarbonate, citric acid and HPMC were used to increase the buoyancy time and decrease the floating lag time. The compressed tablets were evaluated for various parameters like friability, hardness, uniformity of weight, uniformity of drug content, swelling index, bouncy time and in-vitro drug release. Results: The evaluated parameters were in compliance with the pharmacopoeial limits. The most successful formulation was F2, containing xanthan gum as polymer. The drug release was extended up to 10 h which was close to that of theoretical release profile. Mathematical modelling of in-vitro dissolution data indicated the best-fit release kinetics was achieved with Zero order model with R2 values of 0.99. Conclusion: The prepared sustained-release floating tablets of domperidone maleate could perform therapeutically better than that of conventional sustained release tablets with improved efficacy and better patient compliance.
{"title":"Natural Polymer Based Floating Matrix Tablets of Domperidone","authors":"Sheeba Fr, Amar Sahani, Yogesh Db","doi":"10.52711/0975-4377.2022.00044","DOIUrl":"https://doi.org/10.52711/0975-4377.2022.00044","url":null,"abstract":"Aim: This study is aimed to prepare floating matrix Domperidone Maleate tablets by using natural polymers. Materials and Methods: Domperidone maleate was formulated as floating matrix tablets to increase the gastric residence time. Natural polymers like xanthan gum, tragacanth, sodium alginate along with sodium bicarbonate, citric acid and HPMC were used to increase the buoyancy time and decrease the floating lag time. The compressed tablets were evaluated for various parameters like friability, hardness, uniformity of weight, uniformity of drug content, swelling index, bouncy time and in-vitro drug release. Results: The evaluated parameters were in compliance with the pharmacopoeial limits. The most successful formulation was F2, containing xanthan gum as polymer. The drug release was extended up to 10 h which was close to that of theoretical release profile. Mathematical modelling of in-vitro dissolution data indicated the best-fit release kinetics was achieved with Zero order model with R2 values of 0.99. Conclusion: The prepared sustained-release floating tablets of domperidone maleate could perform therapeutically better than that of conventional sustained release tablets with improved efficacy and better patient compliance.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79562094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-12DOI: 10.52711/0975-4377.2022.00055
Deore Nisha N., R. K. Surawase
Nowadays we have all become very aware of toothpaste and its usage. Currently in the market medicated and herbal toothpaste are available. It’s a huge competition for better results from toothpaste for the prevention of tooth problems. Recently daily use lots of dental products and after use, we throw the containers and closures straight in the trash bin without thinking like are they are reusable or not. This is the current case in our country India, comparatively, in other countries, there is a growing awareness about proper waste management and the production of eco-friendly products and reusable. According to a new report published by Allied Market Research, titled, “Toothpaste Tablet Market by Product Type, Flavour Type, Packaging Type, Distribution Channel, and Price Point: Global Opportunity Analysis and Industry Forecast, 2021–2030,” the global toothpaste tablet market size was valued at $45.6 million in 2020, and is projected to reach $90.3 million by 2030, registering a CAGR of 7.3% from 2021 to 2030. Global toothpaste tablets sales are expected to grow at a healthy Compound annual growth rate (CAGR) of over 6.1% during the study forecast period 2021-2031.The toothpaste tablets sales are expected to grow significantly in the coming years. There is a future need in our developing country, however, unfortunately, there is no proper control over this. This review article aims to explore dental problems with sparing on a modified tablet dosage form i.e., chewable tablet toothpaste which will be helpful to reduce plastic waste, will be eco-friendly, cost-effective, and improve dental health.
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