Pub Date : 2019-10-20DOI: 10.36478/rjbsci.2019.56.60
A. Abu-zaiton, M. Abu-Samak, S. Oran, Israa Yousef, Yousef M. Abu-Zaitoon, Ayah Algaramseh
{"title":"Hypoglycemic, Hypolipidimic and Protective Effects of Arbutus andrachne Extract in Streptozotocin Induced Diabetic Rats","authors":"A. Abu-zaiton, M. Abu-Samak, S. Oran, Israa Yousef, Yousef M. Abu-Zaitoon, Ayah Algaramseh","doi":"10.36478/rjbsci.2019.56.60","DOIUrl":"https://doi.org/10.36478/rjbsci.2019.56.60","url":null,"abstract":"","PeriodicalId":21014,"journal":{"name":"Research journal of pharmaceutical, biological and chemical sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87308308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-20DOI: 10.36478/rjbsci.2019.1.6
Abdulrhem Thonnon Al-Ghazal
{"title":"Influence of Avian Influenza Virus on Human Inflammatory Gene Expression Profile","authors":"Abdulrhem Thonnon Al-Ghazal","doi":"10.36478/rjbsci.2019.1.6","DOIUrl":"https://doi.org/10.36478/rjbsci.2019.1.6","url":null,"abstract":"","PeriodicalId":21014,"journal":{"name":"Research journal of pharmaceutical, biological and chemical sciences","volume":"85 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90047747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-20DOI: 10.36478/rjbsci.2019.52.55
Sivakov Vladimir Ilyich, Belousova Natalya Anatolyevna, Kamskova Yuliana Germanovna, Perepelyukova Elena Viktorovna, Matveeva Polina Alexandrovna, Matveev Vitalyi Vladimirovich
{"title":"Prediction of Olympic Results in Skiers of Russia on a Distance of Fifty Kilometers","authors":"Sivakov Vladimir Ilyich, Belousova Natalya Anatolyevna, Kamskova Yuliana Germanovna, Perepelyukova Elena Viktorovna, Matveeva Polina Alexandrovna, Matveev Vitalyi Vladimirovich","doi":"10.36478/rjbsci.2019.52.55","DOIUrl":"https://doi.org/10.36478/rjbsci.2019.52.55","url":null,"abstract":"","PeriodicalId":21014,"journal":{"name":"Research journal of pharmaceutical, biological and chemical sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82917991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-20DOI: 10.36478/rjbsci.2019.61.65
F. Salem, A. Abu-zaiton
Diabetes Mellitus (DM) is a major health concern all over the world. The number of affected people is increasing every year. Many factors contribute to the disease including diet, genetics, lifestyle and so forth. The disease is characterized by hyperglycemia because of insuffiency of the insulin producing beta cells of the pancreas. There is need for alternatives to the conventional antidiabetic drugs to overcome their shortages vitamin D and calcium intake are thought to protect against DM our research aims to evaluate the effect of administration vitamin D, calcium and combination of both on glucose and insulin levels in diabetic rats. Diabetes mellitus was induced intraperitoneally in male Wister albino rats by injection of alloxan (150 mgkgG bw). Animals were divided into seven groups of eight rats each: group I served as normal control, group II act as diabetic control. The diabetic rats treated groups (III, IV, V, VI and VII) were treated, respectively with metformin at dose of 100 mgkgG, vitamin D3 at dose of 12.5 μgkgG, calcium gluconate at dose of 100 mgkgG both vitamin D3 and calcium gluconate and olive oil at dose of 0.3 mLkgG (serve as vehicle group). The treatments were performed by oral administration once a day for 28 consecutive days. The results showed that vitamin D3 and vitamin D3-calcium combination lowers blood glucose level and calcium alone was not statistically significant decreased glucose level. Supplementation with vitamin D3 with or without calcium increases insulin slightly when compared with normal control.
{"title":"Evaluating the Effect of Vitamin D and Calcium on Glucose and Insulin Level of Induced-Diabetic Rats","authors":"F. Salem, A. Abu-zaiton","doi":"10.36478/rjbsci.2019.61.65","DOIUrl":"https://doi.org/10.36478/rjbsci.2019.61.65","url":null,"abstract":"Diabetes Mellitus (DM) is a major health concern all over the world. The number of affected people is increasing every year. Many factors contribute to the disease including diet, genetics, lifestyle and so forth. The disease is characterized by hyperglycemia because of insuffiency of the insulin producing beta cells of the pancreas. There is need for alternatives to the conventional antidiabetic drugs to overcome their shortages vitamin D and calcium intake are thought to protect against DM our research aims to evaluate the effect of administration vitamin D, calcium and combination of both on glucose and insulin levels in diabetic rats. Diabetes mellitus was induced intraperitoneally in male Wister albino rats by injection of alloxan (150 mgkgG bw). Animals were divided into seven groups of eight rats each: group I served as normal control, group II act as diabetic control. The diabetic rats treated groups (III, IV, V, VI and VII) were treated, respectively with metformin at dose of 100 mgkgG, vitamin D3 at dose of 12.5 μgkgG, calcium gluconate at dose of 100 mgkgG both vitamin D3 and calcium gluconate and olive oil at dose of 0.3 mLkgG (serve as vehicle group). The treatments were performed by oral administration once a day for 28 consecutive days. The results showed that vitamin D3 and vitamin D3-calcium combination lowers blood glucose level and calcium alone was not statistically significant decreased glucose level. Supplementation with vitamin D3 with or without calcium increases insulin slightly when compared with normal control.","PeriodicalId":21014,"journal":{"name":"Research journal of pharmaceutical, biological and chemical sciences","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88929976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-28DOI: 10.18231/j.jpbs.2019.003
M. A. R. Al-Maeni
s Alteration of repeat tract length within the SSR of phase variable genes may enhance the persistence of isolates within their host for a long time (a period of months) (Alamro et al.,2014). Alamro et al. (2014) showed there was trend towards selection for OFF state or low expression for five phase variable genes (opc, hmbr, nadA, nalP, hpuAB) in three carriers (V54, V124 and V64) within strains belonging into CC174 and CC167 in first, second and third time points. He concluded that the selection for low or OFF state helped N. meningitidis to persist for a long time (Alamro et al., 2014). The current study aimed to detect the alteration in the repeat tracts of the same five variable genes within the previous three carriers (V54, V124, and V64) but for other strains belonging to CC22, CC269, and CC198 at the fourth time point. There was also a trend towards selection for an OFF state or low expression for three genes which are (opc, hpuAb, nalP) with 2/3 (66.6%) carriers while hmbr gene showed ON state in all carriers (100%). This indicates that antibodies formed against (opc, HpuAb, nalP) genes in strains belonging to CC174 and CC167 in first, second and third time points were able to enhance immunization against the isolates in the current study for CC269 and CC22 resulting in the selection for the OFF state or low expression. Conversely, antibodies formed against hmbr gene in the previous time points on isolates within the CC167 may not show immunization against hmbr gene in the isolates of current study CC22, CC198 and CC269 and so the gene stayed in the ON state. Interestingly, the nadA gene was missing from isolates under the current study. These results may reflect important aspects in the vaccination program especially as nadA is one of the component of Bexsero vaccine.
s改变相变基因的SSR内重复链长度可能会增强分离物在宿主体内的持久性(长达数月)(Alamro et al.，2014)。Alamro et al.(2014)在属于CC174和CC167菌株的三种载体(V54、V124和V64)中，在第一、第二和第三个时间点上，五个相变量基因(opc、hmbr、nadA、nalP、hpuAB)有选择OFF状态或低表达的趋势。他的结论是，低或OFF状态的选择有助于脑膜炎奈瑟菌长期存活(Alamro et al.， 2014)。本研究旨在检测前三个携带者(V54、V124和V64)中相同的5个可变基因的重复序列在第4个时间点的变化，但属于CC22、CC269和CC198的其他菌株在第4个时间点的变化。2/3(66.6%)携带者的opc、hpuAb、nalP基因也有选择OFF或低表达的趋势，hmbr基因在所有携带者中均为ON状态(100%)。这表明CC174和CC167菌株在第1、2和3个时间点形成的针对(opc、HpuAb、nalP)基因的抗体能够增强对本研究中CC269和CC22分离株的免疫，导致其选择OFF状态或低表达。相反，在CC167内的分离株上先前时间点形成的针对hmbr基因的抗体，在当前研究的CC22、CC198和CC269中可能没有显示出对hmbr基因的免疫，因此该基因处于on状态。有趣的是，在目前的研究中，nadA基因在分离株中缺失。这些结果可能反映了疫苗接种计划的重要方面，特别是因为nadA是Bexsero疫苗的成分之一。
{"title":"Analysis of genome variation in Simple sequence repeat (SSR) of meningococcal isolates","authors":"M. A. R. Al-Maeni","doi":"10.18231/j.jpbs.2019.003","DOIUrl":"https://doi.org/10.18231/j.jpbs.2019.003","url":null,"abstract":"s Alteration of repeat tract length within the SSR of phase variable genes may enhance the persistence of isolates within their host for a long time (a period of months) (Alamro et al.,2014). Alamro et al. (2014) showed there was trend towards selection for OFF state or low expression for five phase variable genes (opc, hmbr, nadA, nalP, hpuAB) in three carriers (V54, V124 and V64) within strains belonging into CC174 and CC167 in first, second and third time points. He concluded that the selection for low or OFF state helped N. meningitidis to persist for a long time (Alamro et al., 2014). The current study aimed to detect the alteration in the repeat tracts of the same five variable genes within the previous three carriers (V54, V124, and V64) but for other strains belonging to CC22, CC269, and CC198 at the fourth time point. There was also a trend towards selection for an OFF state or low expression for three genes which are (opc, hpuAb, nalP) with 2/3 (66.6%) carriers while hmbr gene showed ON state in all carriers (100%). This indicates that antibodies formed against (opc, HpuAb, nalP) genes in strains belonging to CC174 and CC167 in first, second and third time points were able to enhance immunization against the isolates in the current study for CC269 and CC22 resulting in the selection for the OFF state or low expression. Conversely, antibodies formed against hmbr gene in the previous time points on isolates within the CC167 may not show immunization against hmbr gene in the isolates of current study CC22, CC198 and CC269 and so the gene stayed in the ON state. Interestingly, the nadA gene was missing from isolates under the current study. These results may reflect important aspects in the vaccination program especially as nadA is one of the component of Bexsero vaccine.","PeriodicalId":21014,"journal":{"name":"Research journal of pharmaceutical, biological and chemical sciences","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76881381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-28DOI: 10.18231/J.JPBS.2019.002
M. A. R. Al-Maeni
Important points were concluded from this analysis related with the presence of the same variable CEs within multiple isolates with different time points being under the selection and the location of SNPs within the conserved functional pattern of CEs. In the 40 isolates, 9 out of 39 variable CEs conducted with multiple isolates, each one affected around 20% or more of population. In the same way, the presence same variable CEs within multiple isolates belonging to same CCs or different CCs of 25 pair isolates detected in 12 out of 137 variable CEs, each one affected around 10% or more out of 25 pair isolates. Interestingly, some CEs showed variation within promoters or IHF patterns or were inserted inside the genes, and were associated with genes that coded mainly for different enzymes within metabolism scheme or transporters within outer membrane scheme in both 40 and 25 pair isolates. This variation may change the level of transcription of genes belonging into previous mentioned schemes and this altered expression may help N. meningitidis to resist the immune system. There were 6 out of 39 and 15 out of 137 variable CEs that showed variation within the conserved functional pattern in 40 isolates and 25 pair isolates respectively. Another function of CEs is as a source of variation in N. meningitidis.
{"title":"Analysis of genome variation in CEs of meningococcal isolates","authors":"M. A. R. Al-Maeni","doi":"10.18231/J.JPBS.2019.002","DOIUrl":"https://doi.org/10.18231/J.JPBS.2019.002","url":null,"abstract":"Important points were concluded from this analysis related with the presence of the same variable CEs within multiple isolates with different time points being under the selection and the location of SNPs within the conserved functional pattern of CEs. In the 40 isolates, 9 out of 39 variable CEs conducted with multiple isolates, each one affected around 20% or more of population. In the same way, the presence same variable CEs within multiple isolates belonging to same CCs or different CCs of 25 pair isolates detected in 12 out of 137 variable CEs, each one affected around 10% or more out of 25 pair isolates. Interestingly, some CEs showed variation within promoters or IHF patterns or were inserted inside the genes, and were associated with genes that coded mainly for different enzymes within metabolism scheme or transporters within outer membrane scheme in both 40 and 25 pair isolates. This variation may change the level of transcription of genes belonging into previous mentioned schemes and this altered expression may help N. meningitidis to resist the immune system. There were 6 out of 39 and 15 out of 137 variable CEs that showed variation within the conserved functional pattern in 40 isolates and 25 pair isolates respectively. Another function of CEs is as a source of variation in N. meningitidis.","PeriodicalId":21014,"journal":{"name":"Research journal of pharmaceutical, biological and chemical sciences","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74907718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-28DOI: 10.18231/J.JPBS.2019.001
P. Muthukumaran, S. Kumaravel, Nimia Nimia
The present study was aimed to analysis of bioactive constituents of Papaver somniferum (Poppy seed). The ethanol extract of the seeds were subjected to Phytochemical Screening, Gas chromatographymass spectroscopic (GC-MS) and Fourier transform infrared spectroscopy (FTIR) analysis. GC-MS analysis of the seeds was performed using a Scion 436GC Bruker model nd Interpretation on mass spectrum GC-MS was conducted using the database of National Institute Standard and Technology (NIST) and IR spectrum was recorded in spectrophotometer (Shimadzu, IR Affinity1, Japan). Phytochemical screening for seeds extracts indicated the presence of various secondary metabolites like Alkaloid, Cardiac Glycosides, Flavonoid, Phytosterols and Terpenoids. GC-MS analysis of compounds with totally, Thirty Nine volatile compounds major chemical compounds were identified, such as 9-Octadecynoic acid(30.72%), 9-Tetradecen1-ol, acetate, (E)(24.02%), 9,12-Octadecadienoic acid, methylester, (E,E)(7.82%), cis-9,10-Epoxyoctadecan-1-ol (7.43%) and Undec10-ynoic acid(4.36%). FT-IR analysis of peak values with various functional compounds such as alcohols, phenols, carboxylic acids, aldehydes, amides, amino acids, anhydrides, esters, ketones, Unsaturated aliphatics, aromatics, unsaturated heterocycles, amines, Nitro compound, Alkanes, alkenes, sugars,Sulphur, phosphorus, and fluorine compounds. The present results concluded that the phytochemicals was observed in ethanol extract which revealed that the Papaver somniferum (Poppy seed) is potential use in different fields namely medical and pharmaceuticals and greatly valuable in medicinal practice for the treatment of several human aliments.
本研究旨在分析罂粟种子的生物活性成分。对种子乙醇提取物进行植物化学筛选、气相色谱-质谱(GC-MS)和傅里叶变换红外光谱(FTIR)分析。采用Scion 436GC布鲁克模型对种子进行气相色谱-质谱分析，质谱分析采用美国国家标准与技术研究所(NIST)数据库，红外光谱用分光光度计(Shimadzu, IR Affinity1, Japan)记录。种子提取物的植物化学筛选表明，其次生代谢产物包括生物碱、心糖苷、类黄酮、植物甾醇和萜类。GC-MS共鉴定出39种挥发性化合物，主要化合物为9-十八烯酸(30.72%)、9-十四烯醇、乙酸(E)(24.02%)、9,12-十八烯酸、甲lester (E,E)(7.82%)、顺式9,10-环氧十八烯醇(7.43%)和十一烯酸(4.36%)。FT-IR分析各种功能化合物的峰值，如醇、酚、羧酸、醛、酰胺、氨基酸、酸酐、酯、酮、不饱和脂肪族、芳烃、不饱和杂环、胺、硝基化合物、烷烃、烯烃、糖、硫、磷和氟化合物。本研究结果表明，在乙醇提取物中观察到植物化学物质，表明罂粟籽在医疗和制药等不同领域具有潜在的用途，在治疗几种人体营养方面具有很大的药用价值。
{"title":"Phytochemical, GC-MS and FT-IR Analysis of Papaver somniferum L","authors":"P. Muthukumaran, S. Kumaravel, Nimia Nimia","doi":"10.18231/J.JPBS.2019.001","DOIUrl":"https://doi.org/10.18231/J.JPBS.2019.001","url":null,"abstract":"The present study was aimed to analysis of bioactive constituents of Papaver somniferum (Poppy seed). The ethanol extract of the seeds were subjected to Phytochemical Screening, Gas chromatographymass spectroscopic (GC-MS) and Fourier transform infrared spectroscopy (FTIR) analysis. GC-MS analysis of the seeds was performed using a Scion 436GC Bruker model nd Interpretation on mass spectrum GC-MS was conducted using the database of National Institute Standard and Technology (NIST) and IR spectrum was recorded in spectrophotometer (Shimadzu, IR Affinity1, Japan). Phytochemical screening for seeds extracts indicated the presence of various secondary metabolites like Alkaloid, Cardiac Glycosides, Flavonoid, Phytosterols and Terpenoids. GC-MS analysis of compounds with totally, Thirty Nine volatile compounds major chemical compounds were identified, such as 9-Octadecynoic acid(30.72%), 9-Tetradecen1-ol, acetate, (E)(24.02%), 9,12-Octadecadienoic acid, methylester, (E,E)(7.82%), cis-9,10-Epoxyoctadecan-1-ol (7.43%) and Undec10-ynoic acid(4.36%). FT-IR analysis of peak values with various functional compounds such as alcohols, phenols, carboxylic acids, aldehydes, amides, amino acids, anhydrides, esters, ketones, Unsaturated aliphatics, aromatics, unsaturated heterocycles, amines, Nitro compound, Alkanes, alkenes, sugars,Sulphur, phosphorus, and fluorine compounds. The present results concluded that the phytochemicals was observed in ethanol extract which revealed that the Papaver somniferum (Poppy seed) is potential use in different fields namely medical and pharmaceuticals and greatly valuable in medicinal practice for the treatment of several human aliments.","PeriodicalId":21014,"journal":{"name":"Research journal of pharmaceutical, biological and chemical sciences","volume":"267 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76278421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-28DOI: 10.18231/j.jpbs.2019.005
M. Akilabalamurugan, K. Iswaryalakshmi
Medicinal plant are the nature’s of gift to human being to make disease free healthy life.It play a vital role to preserve our health. In india different part have been used for curing various diseases from ancient life. In this present study focus on the analysis of priliminary phytochemical in ethanol extract of Asechynomene Aspera Linn root. Among this extract presence of therapeutically important and valuable secondary metabolites flavonoids, alkaloids, trephenoids, steriods and phenol. The antioxidant activity of root sample was evaluvated by using DPPH, ABTS and Nitric oxide reducing activity. The present study showed that good free radical scavenging properties and a clear correlation exist between the antioxidant activity.The ethanolic extract of AsechynomeneAspera Linn root sample was tested for its antibacterial activity against two human bacterial pathogens (E.coli and S.pneumoniae) and using three different concentration by disc diffusion method.The maximum inhibition of antibactrial activity was observed in E.coli. The study concluded that the ethanolic extract of Asechynomene Aspera Linn root has potential antioxidant and antimicrobial action which is responsible for the biological activities that is used for natural health.
{"title":"Phytochemical screening antioxidant and antimicrobial activity of aeschynomene aspera linn root extract","authors":"M. Akilabalamurugan, K. Iswaryalakshmi","doi":"10.18231/j.jpbs.2019.005","DOIUrl":"https://doi.org/10.18231/j.jpbs.2019.005","url":null,"abstract":"Medicinal plant are the nature’s of gift to human being to make disease free healthy life.It play a vital role to preserve our health. In india different part have been used for curing various diseases from ancient life. In this present study focus on the analysis of priliminary phytochemical in ethanol extract of Asechynomene Aspera Linn root. Among this extract presence of therapeutically important and valuable secondary metabolites flavonoids, alkaloids, trephenoids, steriods and phenol. The antioxidant activity of root sample was evaluvated by using DPPH, ABTS and Nitric oxide reducing activity. The present study showed that good free radical scavenging properties and a clear correlation exist between the antioxidant activity.The ethanolic extract of AsechynomeneAspera Linn root sample was tested for its antibacterial activity against two human bacterial pathogens (E.coli and S.pneumoniae) and using three different concentration by disc diffusion method.The maximum inhibition of antibactrial activity was observed in E.coli. The study concluded that the ethanolic extract of Asechynomene Aspera Linn root has potential antioxidant and antimicrobial action which is responsible for the biological activities that is used for natural health.","PeriodicalId":21014,"journal":{"name":"Research journal of pharmaceutical, biological and chemical sciences","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78157104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-15DOI: 10.18231/J.JPBS.2019.004
K. Mohini, Upadhye Mohini, D. Kanchan
The Potential of ayurveda's existence in the medical meadow is strong as more and more researchers, medical scientists and physicians categorise the pitfalls of the conventional medicine. In the present study, we have evaluated some ayurvedic preparations of Taila and Churna for Loss on drying, Ash value, Acid insoluble ash value, Water soluble extractive value, Alcohol soluble extractive value, Refractive Index, Saponification value, Iodine value and Acid value. It was concluded that, among all the churna preparations minimum alcohol extract (%w/w) content and Ash value was found in Avipattikar churna. In Taila preparations, Narayna Taila shows minimum iodine value. The maximum acid value found in Anu Taila and Nirgundi Taila and maximum saponification value found in Anu Taila.
{"title":"Preliminary evalution of ayurvedic preprations of taila ’s and churna’s","authors":"K. Mohini, Upadhye Mohini, D. Kanchan","doi":"10.18231/J.JPBS.2019.004","DOIUrl":"https://doi.org/10.18231/J.JPBS.2019.004","url":null,"abstract":"The Potential of ayurveda's existence in the medical meadow is strong as more and more researchers, medical scientists and physicians categorise the pitfalls of the conventional medicine. In the present study, we have evaluated some ayurvedic preparations of Taila and Churna for Loss on drying, Ash value, Acid insoluble ash value, Water soluble extractive value, Alcohol soluble extractive value, Refractive Index, Saponification value, Iodine value and Acid value. It was concluded that, among all the churna preparations minimum alcohol extract (%w/w) content and Ash value was found in Avipattikar churna. In Taila preparations, Narayna Taila shows minimum iodine value. The maximum acid value found in Anu Taila and Nirgundi Taila and maximum saponification value found in Anu Taila.","PeriodicalId":21014,"journal":{"name":"Research journal of pharmaceutical, biological and chemical sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90283982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-15DOI: 10.18231/J.JPBS.2019.007
R. Agarwal, R. Gupta, R. Yadav, Vivek Asati, J. Rathi
Datura, a wild plant from solanaceae family is very well known for its poisonous and medicinal properties. It contains a wide variety of phytoconstituents such as alkaloids, essential oils, flavonoids, tannins, steroids, glycosides etc. They are responsible for various medicinal properties. Wide variety of pharmacological activities of different species of datura have been reported so far such as anti-inflammatory, anti-diarrhoeal, hypoglycemic activity, anti-viral activity etc. Daturastramonium has been used for curing various ailments including ulcer, wounds, gout, fever, asthma, toothache etc. The aim of present study is to investigate the anti-inflammatory activity of seed extract of Daturastramonium against carrageenan induced paw edema model in albino wistar rats. Keywords: Daturastramonium, Phytoconstituents, Hypoglycemic, Solanaceae, Anti-inflammatory activity.
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