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Anti-Inflammatory activity of seeds extract of datura stramonium against carrageenan induced paw edema on albino wistar rats 曼陀罗籽提取物对卡拉胶诱导的白化wistar大鼠足部水肿的抗炎作用
Pub Date : 2019-07-15 DOI: 10.18231/J.JPBS.2019.007
R. Agarwal, R. Gupta, R. Yadav, Vivek Asati, J. Rathi
Datura, a wild plant from solanaceae family is very well known for its poisonous and medicinal properties. It contains a wide variety of phytoconstituents such as alkaloids, essential oils, flavonoids, tannins, steroids, glycosides etc. They are responsible for various medicinal properties. Wide variety of pharmacological activities of different species of datura have been reported so far such as anti-inflammatory, anti-diarrhoeal, hypoglycemic activity, anti-viral activity etc. Daturastramonium has been used for curing various ailments including ulcer, wounds, gout, fever, asthma, toothache etc. The aim of present study is to investigate the anti-inflammatory activity of seed extract of Daturastramonium against carrageenan induced paw edema model in albino wistar rats. Keywords: Daturastramonium, Phytoconstituents, Hypoglycemic, Solanaceae, Anti-inflammatory activity.
曼陀罗是一种来自茄科的野生植物,以其剧毒和药用特性而闻名。它含有多种植物成分,如生物碱、精油、类黄酮、单宁、类固醇、苷类等。它们负责各种药用特性。不同种类的曼陀罗具有抗炎、抗腹泻、降血糖、抗病毒等药理作用。多图拉莫铵被用于治疗各种疾病,包括溃疡、伤口、痛风、发烧、哮喘、牙痛等。本研究旨在探讨Daturastramonium种子提取物对卡拉胶诱导的白化wistar大鼠足跖水肿模型的抗炎作用。关键词:Daturastramonium,植物成分,降糖,茄科,抗炎活性
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引用次数: 4
Angioedema Of Lower Lip And Gingiva Due To Oral Hormonal Therapy: A Case Report 口服激素治疗致下唇及牙龈血管性水肿1例
Pub Date : 2019-05-09 DOI: 10.33887/RJPBCS/2019.10.3.25
D. Gabrić, B. L. Brzak, V. Boras, Lada Šumilin, Ivana Škrinjar
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引用次数: 0
Effect of Chronic Renal Dialysis on the Level of Thyroid Gland Hormones among Patients with Chronic Renal Failure 慢性肾透析对慢性肾功能衰竭患者甲状腺激素水平的影响
Pub Date : 2019-04-01 DOI: 10.31032/ijbpas/2019/8.4.4692
K. Mansi, S. Altamemi, Sami M. Aloush, M. ALBashtawy
: The purpose of this study was to assess the effect of haemodialysis on thyroxin level in patients with chronic renal failure. The sample of this study included forty nine participants (28 male and 21 female). Eligible participants were patients on regular dialysis for >1 year at the time of enrollment, had no co morbidity and had no known previous thyroid dysfunction. The study was conducted in one educational hospital in Jordan. Serum level of thyroid hormones T4 and T3 were measured prior to the dialysis session and after completion. There was a statistically significant increase in the level of T3 and T4 after completion of dialysis, however, this increase did not go beyond the normal value. Haemodialysis initiate a trend for increase in the level of thyroxin hormones. Patients on chronic dialysis need vigilant assessment for thyroid function in order to prevent future complications.
本研究的目的是评估血液透析对慢性肾功能衰竭患者甲状腺素水平的影响。本研究的样本包括49名参与者(男性28人,女性21人)。符合条件的参与者是在入组时进行常规透析>1年的患者,无合并发病率,既往无已知的甲状腺功能障碍。这项研究是在约旦的一家教育医院进行的。分别在透析前和透析结束后测定血清甲状腺激素T4和T3水平。透析结束后T3、T4水平升高有统计学意义,但未超过正常值。血液透析引起甲状腺激素水平升高的趋势。慢性透析患者需要警惕评估甲状腺功能,以防止未来的并发症。
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引用次数: 3
Mangiferin a bioactive compound of mangifera indica l on oxidative damage and antioxidant status in n-diethylnitrosoamine induced hepatocellular carcinoma in animal model 芒果苷对n-二乙基亚硝基胺诱导的肝细胞癌动物模型氧化损伤及抗氧化状态的影响
Pub Date : 2019-01-15 DOI: 10.18231/2320-1924.2018.0016
M. Saranya, R. Maheswari
Our study aims at elucidating the antioxidant efficiency of Mangiferin from (Mangifera indica L.) for its protective effect beside NNitrosodiethylamine induced Hepatocellular carcinoma (HCC) in rat liver carcinogenesis. Studies have shown that N-Nitrosodiethylamine induces lipid peroxidation and alters the antioxidant status in non-target organisms. An effort has been made to study the effect of NNitrosodiethylamine induced Hepatocellular carcinoma on biochemical parameters and ameliorating results of Mangiferin. Animals were segregated to six groups. Group A served as control, Group B induced with 0.01% DEN through water for 15 weeks to induce hepatocellular carcinoma. Group C received Mangiferin via intragastric intubation at a daily dose of 30 mg/kg body weight for 16 weeks every day. Groups D to F animals received 0.01% of DEN as in Group B along with Mangiferin via intragastric intubation at a daily dose of 10, 20 and 30 mg/kg body weight for throughout the experimental period for 4 month. The study highlights the effectiveness of Mangiferin as protective molecule against N-Nitrosodiethylamine induced carcinoma. Histological studies of liver tissue too correlated with the above biochemical findings. These results clearly suggest that Mangiferin treatment prevents liver damage, lipid peroxidation and protects the antioxidant defense system in DEN-induced liver carcinogenesis in rats.
本研究旨在探讨芒果苷(Mangifera indica L.)的抗氧化作用及其对n亚硝基二乙胺诱导的肝细胞癌(HCC)的保护作用。研究表明,n-亚硝基二乙胺可诱导脂质过氧化并改变非靶生物的抗氧化状态。本文研究了n亚硝基二乙胺诱导肝癌对肝细胞生化指标及芒果苷改善效果的影响。动物被分成六组。A组作为对照组,B组以0.01% DEN水诱导15周肝细胞肝癌。C组大鼠给予芒果苷灌胃,每日剂量为30mg /kg体重,连续16周。D ~ F组与B组一样,给予0.01%的DEN和芒果苷灌胃,剂量分别为10、20和30 mg/kg体重,持续4个月。该研究强调了芒果苷作为保护分子对n -亚硝基二乙胺诱导的癌症的有效性。肝组织的组织学研究也与上述生化结果相关。上述结果提示芒果苷对den诱导的大鼠肝癌具有预防肝损伤、脂质过氧化和保护抗氧化防御系统的作用。
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引用次数: 2
Effects of withania somnifera root extracts on serotonin secretion in suiz albino mice 苦参根提取物对急性白化小鼠血清素分泌的影响
Pub Date : 2019-01-15 DOI: 10.18231/2320-1924.2018.0015
B. Githaiga, E. Lelmen, E. Mwangi, P. Waithaka
Pain is a common manifestation of presence of disease or physical injury in humans. High levels of serotonin in the plasma has been associated with pain. This study aimed at determining the effect of Withania somnifera root extracts on serotonin levels in Suiz albino mice. W. somnifera root samples were collected and ground to small pieces. Ethanol, n-butanol, xylene and methanol were used to extract metabolites from the ground root materials using hot extraction technique. The mice were injected with the extracts separately and serotonin levels determined over a period of 12 h at 2 h intervals. Serotonin concentration was determined using Beer Lamberts method. Light absorbance by the extracts varied significantly (F = 50.2011 P = 1.25x10. The concentrations of serotonin from mice injected with the metabolites from the selected solvents varied significantly (F = 23.3269 P = 0.0000469. In addition, there was no significant difference in light absorbance values obtained by Panadol, methanol and ethanol extracts. (F = 3.7178 P = 0.089). Extracts from W. somnifera have the ability to reduce serotonin levels in plasma. Further studies on the mechanisms involved in reducing serotonin levels by W. somnifera in blood need to be carried out. There is need for mass production of metabolites from W. somnifera.
疼痛是人类疾病或身体损伤的常见表现。血浆中高水平的血清素与疼痛有关。本研究旨在测定苦参根提取物对小鼠血清素水平的影响。收集冬花根样品并磨成小块。以乙醇、正丁醇、二甲苯和甲醇为原料,采用热浸提法提取根物料中的代谢物。小鼠分别注射提取物,并在12小时内每隔2小时测定血清素水平。采用Beer Lamberts法测定血清素浓度。各提取物的吸光度差异显著(F = 50.2011 P = 1.25x10)。所选溶剂代谢物注射小鼠血清素浓度变化显著(F = 23.3269 P = 0.0000469)。此外,Panadol、甲醇和乙醇提取物的吸光度值无显著差异。p = 0.089)。睡眠草提取物具有降低血浆血清素水平的能力。进一步的研究涉及到的机制,降低血中5 -羟色胺水平需要进行。有需要大量生产的代谢物从睡眠。
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引用次数: 2
Secondary metabolism and therapeutic efficacy of medicinal plants 药用植物的次生代谢与疗效
Pub Date : 2019-01-15 DOI: 10.18231/2320-1924.2018.0014
Abdul Kader Mohiuddin
Medicinal plants constitute main resource base of almost all the traditional healthcare systems. Most of the herbal drugs produced currently in majority of the developing countries lack proper quality specification and standards. Herbal drugs used in traditional medicine may contain a single herb or combinations of several different herbs believed to have complementary and/or synergistic effects. Both the raw drugs and the finished herbal products manufactured contain complex mixtures of organic compounds, such as fatty acids, sterols, alkaloids, flavonoids, polyphenols, glycosides, saponins, tannins, terpenes etc. The quality of the finished product is based on the quality of the raw materials. As many as 35% of the medicinal plants used in Indian systems of medicine are highly cross pollinated which indicate the existence of a wide range of genetic variability in the populations of these medicinal plant species which in turn reflected in the variations in the composition of secondary metabolites. Ecological and edaphic as well as seasonal variations also cause changes in the chemical composition of medicinal plants. These facts have to be considered while developing quality parameters! standards of medicinal plants and their finished products.Purpose of the study: An illustrated review of factors that influence secondary metabolism of plants and their impacts on therapeutic efficacy.Findings: Traditional plants are used from ancient time for various human well-being, both as life-saving and lifestyle drugs. A careful observation may explore facts behind therapeutic efficacy of these plants.Materials and Methods: A comprehensive literature review, consulting books, technical newsletters, herb magazines, journals, and many other sources. Health professionals like qualified doctors, herbal specialists, folk healers, alternative medicine specialists given their valuable suggestions. Research limitations: The limitation lies with the unlimited information about traditional medicines. Validity of those are very hard to prove. Only data obtained from books, newsletters, national and international research-based articles are given here along with surrounding facts mostly visible. A few many plant medicine books consulted earlier but article has fewer scope to add from them.Practical Implication: the article is based on plant medicine which is a specialized topic. Students, researchers and professionals may acquire much from this article.
药用植物是几乎所有传统医疗体系的主要资源基础。目前在大多数发展中国家生产的大多数草药缺乏适当的质量规范和标准。传统医学中使用的草药可能含有一种草药或几种被认为具有互补和/或协同作用的不同草药的组合。生产的原料药和草药成品都含有复杂的有机化合物混合物,如脂肪酸、甾醇、生物碱、黄酮类、多酚类、苷类、皂苷类、单宁类、萜烯类等。成品的质量是建立在原材料质量的基础上的。印度医学系统中使用的多达35%的药用植物是高度异花授粉的,这表明在这些药用植物物种的种群中存在广泛的遗传变异,这反过来又反映在次生代谢物组成的变化上。生态和土壤以及季节的变化也会引起药用植物化学成分的变化。在制定质量参数时必须考虑这些事实!药用植物及其制成品标准。研究目的:综述影响植物次生代谢的因素及其对治疗效果的影响。研究发现:自古以来,传统植物就被用于各种人类福祉,既可以拯救生命,也可以改善生活方式。仔细观察可以发现这些植物治疗功效背后的事实。材料和方法:综合文献综述、咨询书籍、技术通讯、草药杂志、期刊和许多其他来源。健康专家,如合格的医生,草药专家,民间治疗师,替代医学专家给出了宝贵的建议。研究局限:局限在于关于传统药物的信息是无限的。这些的有效性很难证明。这里只提供从书籍、时事通讯、国内和国际研究文章中获得的数据,以及周围的事实。一些许多植物药的书籍参考了较早,但文章的范围较少,从他们添加。实用意义:本文以植物医学为基础,是一门专业课题。学生、研究人员和专业人士可以从这篇文章中学到很多东西。
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引用次数: 2
Periapical radiographic technique errors made with digital sensors 数字式传感器引起的根尖周围放射技术误差
Pub Date : 2019-01-15 DOI: 10.18231/2320-1924.2018.0020
Victória Conterato Dias, A. Morosolli, M. I. Rockenbach
Purpose: The objective of this study was to analyze the errors of technique in periapical radiographs as performed by fourth year students at the Dentistry School of the Pontifical Catholic University of Rio Grande do Sul, Brazil. Material and Methods: Fifteen students were randomly selected and each one performed a complete periapical examination in a mannequin. A Direct Digital X-Ray System equipped with a size 2 Sensor was used to obtain the radiographic images. A total of 210 periapical radiographs were evaluated and the images were classified according to the errors that were related to the radiographic technique. The students were also asked to report on their experience with the direct digital system. Results: The absence of a safety margin was the most frequent error on the radiographs that were performed by the students, while elongated image errors were not found. Regarding the radiographed regions, the highest frequency of errors was found in the upper canine region on the left side. Conclusion: The need for a greater training of the students of dentistry, in order to better perform the radiographic technique and to decrease the occurrence of technique errors in periapical radiographs when using a digital receptor, is emphasized. Keywords:Digital radiography, Diagnostic imaging, Learning, Students.
目的:本研究的目的是分析由巴西南里奥格兰德州天主教大学牙科学院四年级学生进行的根尖周x线片技术错误。材料和方法:随机选择15名学生,每个人都在人体模型中进行了完整的根尖周检查。直接数字x射线系统配备了一个尺寸为2的传感器来获得射线图像。对210张根尖周x线片进行评估,并根据与放射技术相关的误差对图像进行分类。学生们还被要求报告他们使用直接数字系统的经验。结果:在学生拍摄的x线片上,最常见的错误是没有安全裕度,而没有发现拉长的图像错误。关于x线摄影区域,最高频率的错误是发现在左上犬区域。结论:需要加强对牙科专业学生的培训,以更好地发挥放射技术,并减少使用数字感受器时根尖周x线片技术错误的发生。关键词:数字放射摄影,诊断成像,学习,学生。
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引用次数: 0
Cinnamon Chewing Gum Induced Oral Allergic Contact Stomatitis 肉桂口香糖致口腔过敏性接触性口炎
Pub Date : 2019-01-01 DOI: 10.33887/RJPBCS/2019.10.3.4
D. Gabrić, V. Boras, L. Vuletić, M. Vuletić, B. Pavelić, A. Glavina
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引用次数: 1
Facile green synthesis of graphene metal nanocomposites and their promising applications 石墨烯金属纳米复合材料的绿色合成及其应用前景
Pub Date : 2018-07-15 DOI: 10.18231/2320-1924.2018.0007
A. G. Patil, P. Patil, Mahesh P. More, Prashant K. Deshmukh, Sanchita S. Mahale
Graphene, a 2D carbon sheet, has attracted tremendous attention in the scientific fraternity. Recently, graphene based metal nanocomposites (GO@Me-NCs) have opened an exciting avenue amongst researchers worldwide, owing to its exceptional properties. Graphene has a high electrical conductivity, exceptional chemical tolerance and large surface-to-volume ratio, which makes it an obvious template for nanocomposites. As a result, incorporation of graphene with inorganic materials such as metal has been the spotlight of research in recent years for their multi-functionalities. From the perspective of chemistry and materials, this account presents an overview of the green and benign processes for fabrication of GO@Me-NCs and their wide range of applications in various fields. Present review highlights the fabrication of GO@Me-NCs by green techniques using plant extracts, carbohydrates, vitamins, amino acids, etc. Finally a concluding remarks are also provided for the researchers, who are interested in designing advanced green strategies for the fabrication of graphene based metal nanocomposites. Keywords: Green synthesis, Graphene, Metal Nanocomposites
石墨烯是一种二维碳片,在科学界引起了极大的关注。最近,石墨烯基金属纳米复合材料(GO@Me-NCs)由于其特殊的性能,在全世界的研究人员中开辟了一条令人兴奋的道路。石墨烯具有高导电性,优异的化学耐受性和大的表面体积比,使其成为纳米复合材料的明显模板。因此,石墨烯与无机材料(如金属)的结合已成为近年来研究的焦点,因为它们具有多功能。从化学和材料的角度,本文概述了制造GO@Me-NCs的绿色和良性工艺及其在各个领域的广泛应用。本文综述了利用植物提取物、碳水化合物、维生素、氨基酸等绿色技术制备GO@Me-NCs的研究进展。最后,本文还为研究人员提供了一个结束语,这些研究人员对石墨烯基金属纳米复合材料的制造设计先进的绿色策略感兴趣。关键词:绿色合成,石墨烯,金属纳米复合材料
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引用次数: 1
The relationship between issues related to occupational attachment of nurses in health and medical centers of Estahban City 埃斯塔班市卫生和医疗中心护士职业依恋相关问题的关系
Pub Date : 2018-05-16 DOI: 10.18231/2320-1924.2018.0003
D. Ranjbar, A. Yazdanpanah, A. KhaniJeihooni
Purpose: Occupational attachment is one of the variables that can be seen by the employees in creating positive consequences for the organization. Career-minded employees form spiritual relationships with their jobs and invest specific resources in their current jobs, and this is one of the important factors in the lives of individuals. The individual's attitude toward his work reflects a negative or positive evaluation that he has in relation to an aspect of his work environment. Among various job attitudes, attachment to a job is a measure that a person likes to match with his job or the extent to which the occupation of the person's identity center is of particular importance. Methods: The research method is applied in terms of purpose and descriptive-applied method. Correlation method has been used. The research sample was 145 nurses of the hospital and health centers of Estahban city who were selected by available sampling method. To evaluate the variables, two questionnaires were used by researcher and occupational attachment questionnaire. Data analysis was done using descriptive statistics using spss software. Results: There is a significant positive relationship between personal factors with occupational attachment (226 / r = r). The higher the individual factors of the nurses, the higher the level of job attachment. There is a significant positive relationship between economic factors with occupational attachment (212.0 r =). The higher the economic factors of nurses, the higher the job attachment. There is a significant positive relationship between organizational factors with occupational attachment (r = .231). The higher the organizational factors in nurses, the higher the level of occupational attachment. There is a significant positive relationship between environmental factors with occupational attachment (r = .249). The higher the nurses' environmental factors, the higher the level of occupational attachment. Conclusion: Therefore, nurses' attachment to their jobs is one of the most important research topics in the field of health systems, since in many countries nurses form one of the largest groups of health professionals. Therefore, the nature and quality of services provided to Patients are highly dependent on their function. Key words: occupational attachment, individual factors, economic factors, organizational factors, environmental factors
目的:职业依恋是员工在为组织创造积极后果时可以看到的变量之一。事业心强的员工与自己的工作形成了精神上的关系,并将特定的资源投入到当前的工作中,这是影响个人生活的重要因素之一。个人对工作的态度反映了他对工作环境的一个方面的消极或积极的评价。在各种工作态度中,对工作的依恋是一种衡量一个人喜欢与他的工作相匹配的程度,或者一个人的身份中心的职业在多大程度上是特别重要的。方法:采用目的性研究和描述性研究相结合的研究方法。采用了相关法。研究对象为埃斯塔班市医院和保健中心的145名护士,采用现有抽样方法。为了评估变量,研究者使用了两份问卷和职业依恋问卷。数据分析采用spss软件进行描述性统计。结果:护士个人因素与职业依恋呈显著正相关(226 / r = r),护士个人因素越高,职业依恋水平越高。经济因素与职业依恋之间存在显著正相关(r = 212.0)。护士经济因素越高,工作依恋程度越高。组织因素与职业依恋之间存在显著正相关(r = .231)。护士组织因素越高,职业依恋水平越高。环境因素与职业依恋存在显著正相关(r = 0.249)。护士环境因素越高,职业依恋水平越高。结论:因此,护士对工作的依恋是卫生系统领域最重要的研究课题之一,因为在许多国家,护士是卫生专业人员中最大的群体之一。因此,向患者提供的服务的性质和质量高度依赖于它们的功能。关键词:职业依恋,个体因素,经济因素,组织因素,环境因素
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引用次数: 0
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Research journal of pharmaceutical, biological and chemical sciences
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