Revista Iberoamericana De Micologia最新文献

英文中文

SARS-CoV-2 and Aspergillus section Fumigati coinfection in an immunocompetent patient treated with corticosteroids 经皮质类固醇治疗的免疫功能正常患者的SARS-CoV-2和烟熏曲霉共感染

IF 1.9 4区生物学 Q4 MYCOLOGY

Revista Iberoamericana De Micologia

Pub Date : 2021-01-01 DOI: 10.1016/j.riam.2020.11.001

Natalia Sasoni , Milton Rodriguez Müller , Graciela Posse , Jorge González , Florencia Leonardelli , Guillermo Garcia-Effron

Background

Patients with severe viral pneumonia are likely to receive high-dose immunomodulatory drugs to prevent clinical worsening. Aspergillus species have been described as frequent secondary pneumonia agents in severely ill influenza patients receiving steroids. COVID-19 patients admitted to Intensive Care Unit (ICU) are receiving steroids as part of their treatment and they share clinical characteristics with other patients with severe viral pneumonias. COVID-19 patients receiving steroids should be considered a putative risk group of invasive aspergillosis.

Case report

We are reporting a SARS-CoV-2/Aspergillus section Fumigati coinfection in an elderly intubated patient with a history of pulmonary embolism treated with corticosteroids. The diagnosis was made following the ad hoc definitions described for patients admitted to ICU with severe influenza, including clinical criteria (fever for 3 days refractory to the appropriate antibiotic therapy, dyspnea, pleural friction rub, worsening of respiratory status despite antibiotic therapy and need of ventilator support), a radiological criterion (pulmonary infiltrate) and a mycological criterion (several positive galactomannan tests on serum with ratio ≥0.5). In addition, Aspergillus section Fumigati DNA was found in serum and blood samples. These tests were positive 4 weeks after the patient was admitted to the ICU. The patient received voriconazole and after two month in ICU his respiratory status improved; he was discharged after 6 weeks of antifungal treatment.

Conclusions

Severely ill COVID-19 patients would be considered a new aspergillosis risk group. Galactomannan and Aspergillus DNA detection would be useful methods for Aspergillus infection diagnosis as they allow avoiding the biosafety issues related to these patients.

背景:严重病毒性肺炎患者可能会接受大剂量免疫调节药物，以防止临床恶化。曲霉属已被描述为在接受类固醇治疗的严重流感患者中常见的继发性肺炎病原体。入住重症监护病房(ICU)的COVID-19患者正在接受类固醇治疗，他们与其他严重病毒性肺炎患者具有相同的临床特征。接受类固醇治疗的COVID-19患者应被视为侵袭性曲霉病的推定危险群体。病例报告:我们报告一例接受过皮质类固醇治疗的肺栓塞史的老年插管患者发生SARS-CoV-2/烟状曲霉段合并感染。根据重症流感入院患者的特殊定义进行诊断，包括临床标准(发热3天，抗生素治疗无效，呼吸困难，胸膜摩擦摩擦，抗生素治疗后呼吸状况恶化，需要呼吸机支持)，放射学标准(肺浸润)和真菌学标准(血清中几项半乳甘露annan阳性，比例≥0.5)。此外，在血清和血液样本中发现了烟熏曲霉片段DNA。患者入住ICU后4周，这些检查均呈阳性。患者接受伏立康唑治疗，ICU治疗2个月后呼吸状况好转;经6周抗真菌治疗后出院。结论重症COVID-19患者可视为新的曲霉病危险人群。半乳甘露聚糖和曲霉DNA检测可以避免曲霉感染患者的生物安全问题，是诊断曲霉感染的有效方法。

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引用次数: 9

IX Fórum Micológico-Asociación Española de Micología (AEM) 第九届真菌学论坛-西班牙真菌学协会(AEM)

IF 1.9 4区生物学 Q4 MYCOLOGY

Revista Iberoamericana De Micologia

Pub Date : 2021-01-01 DOI: 10.1016/j.riam.2021.01.002

引用次数: 0

Micología y salud: una mirada desde el futuro 真菌学与健康:来自未来的展望

IF 1.9 4区生物学 Q4 MYCOLOGY

Revista Iberoamericana De Micologia

Pub Date : 2021-01-01 DOI: 10.1016/j.riam.2021.01.001

引用次数: 0

Aspergillosis in cats and dogs: Not everything green is Aspergillus fumigatus 猫和狗的曲霉病:不是所有绿色的都是烟曲霉

IF 1.9 4区生物学 Q4 MYCOLOGY

Revista Iberoamericana De Micologia

Pub Date : 2020-07-01 DOI: 10.1016/j.riam.2020.02.001

F. Javier Cabañes

引用次数: 4

Problemas clínicos en micología médica: problema número 54 医学真菌学的临床问题:第54期

IF 1.9 4区生物学 Q4 MYCOLOGY

Revista Iberoamericana De Micologia

Pub Date : 2020-07-01 DOI: 10.1016/j.riam.2020.04.001

Fernando Messina , Ricardo Negroni , Elena Maiolo , Alicia Arechavala , María Mercedes Romero , Silvia Paz , Hugo Fainboim , Gabriela María Santiso

引用次数: 0

Disseminated sporotrichosis with immune reconstitution inflammatory syndrome in an HIV patient: Case report and review of the literature 1例HIV患者播散性孢子菌病伴免疫重建炎症综合征:病例报告及文献复习

IF 1.9 4区生物学 Q4 MYCOLOGY

Revista Iberoamericana De Micologia

Pub Date : 2020-07-01 DOI: 10.1016/j.riam.2020.09.001

Vanice Rodrigues Poester , Lívia Silveira Munhoz , Rossana Patricia Basso , Beatriz Mendes Roca , Mariana Umpiérrez Vieira , Aryse Martins Melo , Gabriel Baracy Klafke , Karine Ortiz Sanchotene , Jussara Maria Silveira , David Stevens , Vanessa Brito de Souza Rabello , Rosely Maria Zancope-Oliveira , Melissa Orzechowski Xavier

Background

Sporotrichosis has been occurring as outbreaks in Brazil, reaching epidemic levels in some regions. Zoonotic transmission is the main route to acquire Sporothrix.

Case report

We describe a case of disseminated sporotrichosis caused by Sporothrix brasiliensis in an HIV/AIDS patient, with the presentation of immune reconstitution inflammatory syndrome (IRIS).

Conclusions

This case reinforces that sporotrichosis should always be suspected in patients with IRIS from endemic regions, even in patients without the typical cutaneous lesions of this mycosis.

孢子虫病一直在巴西暴发，在一些地区达到流行水平。人畜共患传播是获得孢子丝菌的主要途径。病例报告我们报告了一例由巴西孢子菌引起的播散性孢子菌病，患者为HIV/AIDS患者，表现为免疫重建炎症综合征(IRIS)。结论本病例强调，来自流行地区的IRIS患者应始终怀疑孢子虫病，即使患者没有这种真菌病的典型皮肤病变。

引用次数: 9

Trichophyton erinacei: an emergent pathogen of pediatric dermatophytosis 毛癣菌:儿童皮肤真菌病的一种新兴病原体

IF 1.9 4区生物学 Q4 MYCOLOGY

Revista Iberoamericana De Micologia

Pub Date : 2020-07-01 DOI: 10.1016/j.riam.2020.06.001

Belén Rivaya , Gema Fernández-Rivas , Francisco Javier Cabañes , Isabel Bielsa , Gemma Castellá , Jun Hao Wang , Lurdes Matas

Background

Dermatophytoses in children are common pathologies worldwide caused mainly by Trichophyton rubrum. However, due to the globalization and the atypical pets that people nowadays own, some zoonotic species are also involved in these lesions.

Case report

We present two cases of tinea faciei caused by the zoonotic mould Trichophyton erinacei in two children that owned a guinea pig and a hedgehog, respectively. Mycological diagnosis was performed inoculating skin scales on Sabouraud-glucose agar plates supplemented with chloramphenicol, with and without gentamicin, and on Sabouraud-glucose agar tubes, with and without cycloheximide. Microscopical examination in both cases and ITS region sequencing to confirm the identification (performed in one of them) were compatible with T. erinacei. Multiple treatments like corticosteroids and antibiotics were prescribed prior to the accurate diagnosis. Finally, both patients received topical and oral terbinafine, respectively, the lesions being resolved entirely.

Conclusions

Zoonotic fungi must be considered in the diagnosis of skin lesions. An accurate medical record, with a guided anamnesis about possible risk factors and an ongoing and open dialogue between health professionals, are essential to improve both the management of these exotic and zoophilic dermatophytoses.

背景:儿童皮癣是世界范围内主要由红毛癣菌引起的常见疾病。然而，由于全球化和现在人们拥有的非典型宠物，一些人畜共患物种也涉及这些病变。病例报告:我们报告了两例由人畜共患霉菌毛癣引起的面部癣，这两例患儿分别拥有一只豚鼠和一只刺猬。将皮肤鳞片接种于加氯霉素和不加庆大霉素的sabouraud -葡萄糖琼脂平板上，接种于加环己亚胺和不加环己亚胺的sabouraud -葡萄糖琼脂管上，进行真菌学诊断。两例病例的显微镜检查和ITS区域测序确认鉴定(其中一例)与T. erinacei一致。在准确诊断之前，医生开出了皮质类固醇和抗生素等多种治疗方案。最后，两名患者分别接受局部和口服特比萘芬治疗，病变完全消退。结论人畜共患真菌在皮损诊断中必须加以考虑。准确的医疗记录，对可能的风险因素进行指导，并在卫生专业人员之间进行持续和公开的对话，对于改善这些外来和嗜兽性皮肤真菌病的管理至关重要。

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引用次数: 3

Sporotrichosis in Brazil: Animals + humans = one health 巴西的孢子虫病:动物+人类=一个健康

IF 1.9 4区生物学 Q4 MYCOLOGY

Revista Iberoamericana De Micologia

Pub Date : 2020-07-01 DOI: 10.1016/j.riam.2020.01.001

F. Javier Cabañes

引用次数: 7

Infección del torrente sanguíneo por Candida glabrata en una unidad de cuidados intensivos neonatales con prescripción de profilaxis con fluconazol 新生儿重症监护病房使用氟康唑预防的光滑念珠菌血流感染

IF 1.9 4区生物学 Q4 MYCOLOGY

Revista Iberoamericana De Micologia

Pub Date : 2020-07-01 DOI: 10.1016/j.riam.2020.06.002

Juan Carlos Lona-Reyes , Larissa María Gómez-Ruiz , Araceli Cordero-Zamora , Mariana Chávez-Rodríguez , Juan Antonio Gallegos-Marín , Denisse Sinaí Jiménez-Hernández

Background

Candida glabrata is an emerging pathogen with the ability to develop tolerance and resistance to azole antifungals, which creates uncertainty about the usefulness of antifungal prophylaxis in newborns.

Aims

The aim of this study was to describe the factors associated with C. glabrata infection in a NICU that uses prophylaxis with fluconazole.

Methods

A case-control study paired by gestational age was designed and conducted at the Civil Hospital of Guadalajara Dr. Juan I. Menchaca. Newborns with C. glabrata infection were studied and for each one a matched control was selected by gestational age. Odds ratios (OR) were estimated with 95% confidence intervals (95% CI) and McNemar test for contrast of hypothesis was applied.

Results

Twenty-one infected patients were identified, from whom 66.7% were male; the median gestational age was 31.5 weeks. Increased risk of infection with C. glabrata was observed when there was a prescription of more than one antimicrobial scheme (OR 21, 95% CI, 1.23 - 358.3; p = 0.006) and also among patients with surgical comorbidities (OR 8, 95% CI 1.01 - 63.9; p = 0.04). During the study period, exposure to fluconazole showed no difference in the risk of infection.

Conclusions

Neonates with more than one antimicrobial regimen and those with surgical comorbidities had a higher risk of C. glabrata infection.

背景:光念珠菌是一种新兴的病原体，具有对唑类抗真菌药物产生耐受性和耐药性的能力，这给新生儿抗真菌预防的有效性带来了不确定性。目的本研究的目的是描述在使用氟康唑预防的NICU中与光滑棘球蚴感染相关的因素。方法在瓜达拉哈拉市立医院Juan I. Menchaca医生设计并进行了一项按胎龄配对的病例对照研究。研究了患有光棘球蚴感染的新生儿，并根据胎龄选择了一个匹配的对照。比值比(OR)以95%置信区间(95% CI)估计，采用McNemar假设对比检验。结果共发现感染病例21例，其中男性占66.7%;中位胎龄为31.5周。当处方中有一种以上的抗菌方案时，观察到光斑梭菌感染的风险增加(OR 21, 95% CI, 1.23 - 358.3;p = 0.006)以及手术合并症患者(OR 8, 95% CI 1.01 - 63.9;p = 0.04)。在研究期间，暴露于氟康唑对感染风险没有影响。结论服用一种以上抗菌药物的患者及有手术合并症的患者有较高的光棘球蚴感染风险。

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引用次数: 3

Identification of Mucor circinelloides antigens recognized by sera from immunocompromised infected mice 免疫功能低下感染小鼠血清中环状毛霉抗原的鉴定

IF 1.9 4区生物学 Q4 MYCOLOGY

Revista Iberoamericana De Micologia

Pub Date : 2020-07-01 DOI: 10.1016/j.riam.2020.07.002

Maialen Areitio , Adela Martin-Vicente , Aitana Arbizu , Aitziber Antoran , Leire Aparicio-Fernandez , Idoia Buldain , Leire Martin-Souto , Aitor Rementeria , Javier Capilla , Fernando L. Hernando , Andoni Ramirez-Garcia

Background

Mucor circinelloides is an opportunistic fungus capable of causing mucormycosis, a highly aggressive infection of quick spreading. Besides, it also has a high mortality rate due to late diagnosis and difficult treatment.

Aims

In this study we have identified the most immunoreactive proteins of the secretome and the total protein extract of M. circinelloides using sera from immunocompromised infected mice.

Methods

The proteins of the secretome and the total extract were analyzed by two-dimensional electrophoresis and the most immunoreactive antigens were detected by Western Blot, facing the sera of immunocompromised infected mice to the proteins obtained in both extracts of M. circinelloides.

Results

Seven antigens were detected in the secretome extract, and two in the total extract, all of them corresponding only to three proteins. The enzyme enolase was detected in both extracts, while triosephosphate isomerase was detected in the secretome, and heat shock protein HSS1 in the total extract.

Conclusions

In this work the most immunoreactive antigens of the secretome and the total extract of M. circinelloides were identified. The identified proteins are well known fungal antigens and, therefore, these findings can be useful for future research into alternatives for the diagnosis and treatment of mucormycosis.

背景:环形毛霉是一种能够引起毛霉病的机会性真菌，这是一种快速传播的高度侵袭性感染。此外，由于诊断晚，治疗困难，死亡率高。目的在本研究中，我们利用免疫功能低下的感染小鼠血清，鉴定了环状螺旋杆菌分泌组的大部分免疫反应蛋白和总蛋白提取物。方法采用双向电泳分析分泌组蛋白和总提取物蛋白，采用免疫印迹法检测免疫功能低下小鼠血清对两种提取物蛋白的免疫反应性。结果分泌组提取物中检测到7种抗原，总提取物中检测到2种抗原，均仅对应3种蛋白。两种提取物中均检测到烯醇化酶，分泌组中检测到三磷酸异构酶，总提取物中检测到热休克蛋白HSS1。结论本工作鉴定出了麻霉分泌组和总提取物的大部分免疫活性抗原。鉴定的蛋白质是众所周知的真菌抗原，因此，这些发现对未来研究毛霉病的诊断和治疗的替代方法是有用的。

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