Özge Göktepe, Venhar Çinar, Zuhal Hamurcu, Birkan Yakan
Breast cancer is one of the most prominent causes of mortality among women worldwide due to factors such as aggressive behavior of the cancer and resistance to chemotherapeutic agents. Resistance to chemotherapeutic drugs in cancer treatment is a common phenomenon, especially in progressive diseases with a high prevalence. Therefore the current study aimed to demonstrate the anti-cancer effects of GL on MDA-MB-231 and MCF-7 cell lines. We showed the effect of GL on cell proliferation using the MTS method, its effect on clone formation with a clonogenic test, and we also evaluated whether the apoptotic pathway was activated by western blot. GL significantly inhibited cell proliferation depending on the dose in MDA-MB-231 and MCF-7 cell lines and it significantly reduced the number of colonies compared to non-treated cells. In addition, GL induced the initiation of apoptosis in MDA-MB-231 and MCF-7 cells, as evidenced by an enhanced level of caspase-8 and caspase-9 and decreased expression of PARP. These results demonstrated the molecular mechanism underlying the anti-cancer effects of GL, suggesting that GL might be useful in anticancer therapy. Novel products, such as GL, undoubtedly have promise for the future.
{"title":"Ganoderma lucidum Fruiting Body Dry Extract, meme kanseri hücre proliferasyonunu inhibe eder ve hem kaspaz-8 hem de kaspaz-9'u aktive ederek apoptozu indükler.","authors":"Özge Göktepe, Venhar Çinar, Zuhal Hamurcu, Birkan Yakan","doi":"10.31832/smj.1291743","DOIUrl":"https://doi.org/10.31832/smj.1291743","url":null,"abstract":"Breast cancer is one of the most prominent causes of mortality among women worldwide due to factors such as aggressive behavior of the cancer and resistance to chemotherapeutic agents. Resistance to chemotherapeutic drugs in cancer treatment is a common phenomenon, especially in progressive diseases with a high prevalence. Therefore the current study aimed to demonstrate the anti-cancer effects of GL on MDA-MB-231 and MCF-7 cell lines. \u0000We showed the effect of GL on cell proliferation using the MTS method, its effect on clone formation with a clonogenic test, and we also evaluated whether the apoptotic pathway was activated by western blot. \u0000GL significantly inhibited cell proliferation depending on the dose in MDA-MB-231 and MCF-7 cell lines and it significantly reduced the number of colonies compared to non-treated cells. In addition, GL induced the initiation of apoptosis in MDA-MB-231 and MCF-7 cells, as evidenced by an enhanced level of caspase-8 and caspase-9 and decreased expression of PARP. \u0000These results demonstrated the molecular mechanism underlying the anti-cancer effects of GL, suggesting that GL might be useful in anticancer therapy. Novel products, such as GL, undoubtedly have promise for the future.","PeriodicalId":21405,"journal":{"name":"Sakarya Medical Journal","volume":"2014 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87756751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
İbrahim Uygun, Şeyma Nur BAŞARIR BOZKURT, Mohammad AL YOUSEF, Mohammed Omer Khalid Mohammed, Pelin Tanyeri̇, Firuzan Akar, B. F. Erden, Oguz Mutlu
Amaç: Önceki çalışmalarımızda adipokinetik hormonun (AKH) farelerde antidepresan, anksiyolitik, analjezik etkilerini, nörotrofik faktörleri ve nörojenezi artırdığını gösterdik. Önceki çalışmamızda, AKH’nun sıçanlara intraperitoneal uygulanmasından sonra diğer çalışmalarla desteklendiği şekilde piroglutamil peptidleri içeren AKH metabolitlerinin kan-beyin bariyerini geçtiğini hipotez ettik. Gereç ve Yöntemler: Bu çalışmada, iki piroglutamil peptidin öğrenme-bellek üzerine etkisini modifiye yükseltilmiş artı labirent testinde (mYAL) ve pasif sakınma testinde hem naif farelerde hem de skopolaminle indüklenen bellek bozukluğu üzerine etkisini incelemeyi amaçladık. Skopolamin (1 mg/kg) ile piroglutamil peptid olarak piroglutamik asid-valin (pGlu-Val; 10 ve 20 mg/kg), piroglutamik asid-lösin (pGlu-Leu; 10 ve 20 mg/kg) kullandık. Bulgular: mYAL testinde dipeptidlerin naif farelerde geçiş süresi-2 üzerine anlamlı etkisi yoktu. Skopolamin kısmi olarak ikinci denemede geçiş süresi-2’yi artırırken, bu etki pGlu-Leu (10 ve 20 mg/kg; p
{"title":"Piroglutamil Peptidlerin Farelerde Skopolaminle Oluşturulmuş Öğrenme-Bellek Bozukluğu Üzerine Etkisi","authors":"İbrahim Uygun, Şeyma Nur BAŞARIR BOZKURT, Mohammad AL YOUSEF, Mohammed Omer Khalid Mohammed, Pelin Tanyeri̇, Firuzan Akar, B. F. Erden, Oguz Mutlu","doi":"10.31832/smj.1239798","DOIUrl":"https://doi.org/10.31832/smj.1239798","url":null,"abstract":"Amaç: Önceki çalışmalarımızda adipokinetik hormonun (AKH) farelerde antidepresan, anksiyolitik, analjezik etkilerini, nörotrofik faktörleri ve nörojenezi artırdığını gösterdik. Önceki çalışmamızda, AKH’nun sıçanlara intraperitoneal uygulanmasından sonra diğer çalışmalarla desteklendiği şekilde piroglutamil peptidleri içeren AKH metabolitlerinin kan-beyin bariyerini geçtiğini hipotez ettik. \u0000Gereç ve Yöntemler: Bu çalışmada, iki piroglutamil peptidin öğrenme-bellek üzerine etkisini modifiye yükseltilmiş artı labirent testinde (mYAL) ve pasif sakınma testinde hem naif farelerde hem de skopolaminle indüklenen bellek bozukluğu üzerine etkisini incelemeyi amaçladık. Skopolamin (1 mg/kg) ile piroglutamil peptid olarak piroglutamik asid-valin (pGlu-Val; 10 ve 20 mg/kg), piroglutamik asid-lösin (pGlu-Leu; 10 ve 20 mg/kg) kullandık. \u0000Bulgular: mYAL testinde dipeptidlerin naif farelerde geçiş süresi-2 üzerine anlamlı etkisi yoktu. Skopolamin kısmi olarak ikinci denemede geçiş süresi-2’yi artırırken, bu etki pGlu-Leu (10 ve 20 mg/kg; p","PeriodicalId":21405,"journal":{"name":"Sakarya Medical Journal","volume":"120 12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83571367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aysel Toçoğlu, E. Akçay, Ayfer ERDOĞAN ALTAŞ, Sabah Tuzun, B. Doğan, Emel Gönüllü
Amaç: Sistemik İnflamasyon indeksi (SII) ve trombosit albümin oranı (PAR) inflamasyonu değerlendirmek için öne sürülen yeni biyobelirteçlerdir. Çalışmamızda Ankilozan Spondilit (AS) hastalarında hastalık aktivitesi ile SII ve PAR arasındaki ilişkiyi incelemeyi amaçladık. Yöntem ve Gereçler: AS’li 79 hasta ile 79 sağlıklı kontrol retrospektif olarak değerlendirildi. Katılımcıların demografik, klinik ve laboratuvar verileri poliklinik verileri incelenerek hastane bilgi sistemi üzerinden kayıt edildi. AS grubunda hastalık aktivite durumu Bath Ankilozan Spondilit Hastalık Aktivite İndeksi (BASDAI) skoru hesaplanarak tayin edildi. BASDAI skoru ≥4 olanlar aktif hasta olarak kabul edildi. Aktif hastalığı olan AS hastaları ile remisyonda olan hastalar SII ve PAR açısından karşılaştırıldı. Bulgular: AS grubunun yaş ortalaması 42,53±6,60, sağlıklı grubun 41,37±10,86 yıldı (p=0,460). AS grubunda 49 (%62,0), sağlıklı grupta 35 (44,3) katılımcı erkekti (p=0,026). AS grubunda sağlıklı gruba göre SII, PAR ve C-reaktif protein albümin oranı (CAR) değerlerinin istatistiksel olarak anlamlı oranda daha yüksek olduğu tespit edildi (sırasıyla p0.05). Sonuç: AS hastalarında sağlıklı kontroller ile karşılaştırıldığında SII ve PAR değerlerinin artmış olduğu tespit edilirken, beklenenin aksine hastalık aktivitesi ile SII ve PAR değerleri arasında herhangi bir ilişki tespit edilemedi.
{"title":"Ankilozan Spondilit Hastalarında Hastalık Aktivitesi ile Sistemik İnflamasyon İndeksi ve Trombosit Albumin Oranı Arasındaki İlişki The relationship Between Disease Activity and Systemic Inflammation Index and Platelet Albumin Ratio in Patients with Ankylosing Spondylitis","authors":"Aysel Toçoğlu, E. Akçay, Ayfer ERDOĞAN ALTAŞ, Sabah Tuzun, B. Doğan, Emel Gönüllü","doi":"10.31832/smj.1288358","DOIUrl":"https://doi.org/10.31832/smj.1288358","url":null,"abstract":"Amaç: Sistemik İnflamasyon indeksi (SII) ve trombosit albümin oranı (PAR) inflamasyonu değerlendirmek için öne sürülen yeni biyobelirteçlerdir. Çalışmamızda Ankilozan Spondilit (AS) hastalarında hastalık aktivitesi ile SII ve PAR arasındaki ilişkiyi incelemeyi amaçladık. \u0000Yöntem ve Gereçler: AS’li 79 hasta ile 79 sağlıklı kontrol retrospektif olarak değerlendirildi. Katılımcıların demografik, klinik ve laboratuvar verileri poliklinik verileri incelenerek hastane bilgi sistemi üzerinden kayıt edildi. AS grubunda hastalık aktivite durumu Bath Ankilozan Spondilit Hastalık Aktivite İndeksi (BASDAI) skoru hesaplanarak tayin edildi. BASDAI skoru ≥4 olanlar aktif hasta olarak kabul edildi. Aktif hastalığı olan AS hastaları ile remisyonda olan hastalar SII ve PAR açısından karşılaştırıldı. \u0000Bulgular: AS grubunun yaş ortalaması 42,53±6,60, sağlıklı grubun 41,37±10,86 yıldı (p=0,460). AS grubunda 49 (%62,0), sağlıklı grupta 35 (44,3) katılımcı erkekti (p=0,026). AS grubunda sağlıklı gruba göre SII, PAR ve C-reaktif protein albümin oranı (CAR) değerlerinin istatistiksel olarak anlamlı oranda daha yüksek olduğu tespit edildi (sırasıyla p0.05). \u0000Sonuç: AS hastalarında sağlıklı kontroller ile karşılaştırıldığında SII ve PAR değerlerinin artmış olduğu tespit edilirken, beklenenin aksine hastalık aktivitesi ile SII ve PAR değerleri arasında herhangi bir ilişki tespit edilemedi.","PeriodicalId":21405,"journal":{"name":"Sakarya Medical Journal","volume":"79 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89426083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Polypharmacy is frequently used in the treatment of the bipolar disorder. We aimed to investigate polypharmacy rates, associated factors, and the types of drugs preferred in treatment among outpatients with bipolar disorder. Method: A total of 209 bipolar disorder patients attending an outpatient psychiatry clinic were included in this study. Drug types, active substances, and combination forms were examined. Results: The rate of polypharmacy among bipolar outpatients was 79.40%. Antipsychotics were the most frequently preferred drug for the treatment. The most commonly used antipsychotic was quetiapine, whereas the mood stabilizer was sodium valproate and the antidepressant was paroxetine. The most common form of treatment for bipolar disorder was the combined use of a mood stabilizer and an antipsychotic. Conclusion: In contrast to treatment guidelines, polypharmacy has virtually become a standard in the treatment of bipolar disorder. It appears that the adoption of polypharmacy in treatment will persist for various reasons. As such, there is a need to develop new guidelines to guide psychiatrists in determining the patient groups and combinations in which combination therapy will be preferred. Moreover, interventions are needed to minimize the possible side effects, and risk of drug-drug interactions related to the use of multiple drugs, determine the benefit/harm ratio and reduce unnecessary psychotropic drug use.
{"title":"Polypharmacy in Outpatients with Bipolar Disorder: Associated Factors and Treatment Characteristics in Türkiye","authors":"Neriman Aras, Fatma Çoker, Nihan Küçük","doi":"10.31832/smj.1178583","DOIUrl":"https://doi.org/10.31832/smj.1178583","url":null,"abstract":"Objective: Polypharmacy is frequently used in the treatment of the bipolar disorder. We aimed to investigate polypharmacy rates, associated factors, and the types of drugs preferred in treatment among outpatients with bipolar disorder. \u0000Method: A total of 209 bipolar disorder patients attending an outpatient psychiatry clinic were included in this study. Drug types, active substances, and combination forms were examined. \u0000Results: The rate of polypharmacy among bipolar outpatients was 79.40%. Antipsychotics were the most frequently preferred drug for the treatment. The most commonly used antipsychotic was quetiapine, whereas the mood stabilizer was sodium valproate and the antidepressant was paroxetine. The most common form of treatment for bipolar disorder was the combined use of a mood stabilizer and an antipsychotic. \u0000Conclusion: In contrast to treatment guidelines, polypharmacy has virtually become a standard in the treatment of bipolar disorder. It appears that the adoption of polypharmacy in treatment will persist for various reasons. As such, there is a need to develop new guidelines to guide psychiatrists in determining the patient groups and combinations in which combination therapy will be preferred. Moreover, interventions are needed to minimize the possible side effects, and risk of drug-drug interactions related to the use of multiple drugs, determine the benefit/harm ratio and reduce unnecessary psychotropic drug use.","PeriodicalId":21405,"journal":{"name":"Sakarya Medical Journal","volume":"253 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76885217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives The relationship between clinical and laboratory parameters associated with the neuropathic pain presence in Psoriatic Arthritis is not well known and has not been adequately studied. Based on these assumptions, the aim of our study is to investigate how often neuropathic pain occurs in Psoriatic Arthritis patients and how much it is related to the clinical and laboratory parameters of the disease. Methods In the cross-sectional study, 45 Psoriatic Arthritis patients diagnosed according to The Classification Criteria for Psoriatics were included. In our study, Pain Detect Questionnaire (PDQ) was used to assess the neuropathic pain characteristics. Presence of enthesitis was determined by SPARCC to ensure objective measurements. Functional status was evaluated with the Health Assessment Questionnaire (HAQ). The Short Form-36 (SF-36) questionnaire was used to evaluate the quality of life. Results A total of 45 patients were included in the study. The mean duration of symptoms was 78.91 ± 95.8 months. There are 16 patients receiving Nsaid treatment, 28 patients receiving DMARD treatment, and 13 patients receiving biological therapy. Among the patients included in the study, 30 patients with neuropathic pain and 15 without neuropathic pain were found according to the Pain Detect questionnaire. A significant difference was observed between these two groups in the results of DAPSA, VAS movement, HAQ, morning stiffness, and SF-36 Body pain. Conclusion Our study has shown that neuropathic pain has a high prevalence in Psoriatic Arthritis patients. This association was observed to be related to functional limitation. Additionally, the DAPSA score was found to be significantly higher in patients with neuropathic pain due to pain sensation which suggests that it may be a factor reducing treatment success. It is conceivable that the recognition and treatment of neuropathic pain may increase the success of Psoriatic Arthritis treatment.
{"title":"Neuropathic Pain in Patients with Psoriatic Arthritis: A Bystander or a Gamechanger?","authors":"Mehmet Serkan Kılıçoğlu, Mert Kara, O. Yurdakul","doi":"10.31832/smj.1181721","DOIUrl":"https://doi.org/10.31832/smj.1181721","url":null,"abstract":"Objectives \u0000 \u0000The relationship between clinical and laboratory parameters associated with the neuropathic pain presence in Psoriatic Arthritis is not well known and has not been adequately studied. Based on these assumptions, the aim of our study is to investigate how often neuropathic pain occurs in Psoriatic Arthritis patients and how much it is related to the clinical and laboratory parameters of the disease. \u0000 \u0000Methods \u0000 \u0000In the cross-sectional study, 45 Psoriatic Arthritis patients diagnosed according to The Classification Criteria for Psoriatics were included. In our study, Pain Detect Questionnaire (PDQ) was used to assess the neuropathic pain characteristics. Presence of enthesitis was determined by SPARCC to ensure objective measurements. Functional status was evaluated with the Health Assessment Questionnaire (HAQ). The Short Form-36 (SF-36) questionnaire was used to evaluate the quality of life. \u0000 \u0000Results \u0000 \u0000A total of 45 patients were included in the study. The mean duration of symptoms was 78.91 ± 95.8 months. There are 16 patients receiving Nsaid treatment, 28 patients receiving DMARD treatment, and 13 patients receiving biological therapy. Among the patients included in the study, 30 patients with neuropathic pain and 15 without neuropathic pain were found according to the Pain Detect questionnaire. A significant difference was observed between these two groups in the results of DAPSA, VAS movement, HAQ, morning stiffness, and SF-36 Body pain. \u0000 \u0000Conclusion \u0000 \u0000Our study has shown that neuropathic pain has a high prevalence in Psoriatic Arthritis patients. This association was observed to be related to functional limitation. Additionally, the DAPSA score was found to be significantly higher in patients with neuropathic pain due to pain sensation which suggests that it may be a factor reducing treatment success. It is conceivable that the recognition and treatment of neuropathic pain may increase the success of Psoriatic Arthritis treatment.","PeriodicalId":21405,"journal":{"name":"Sakarya Medical Journal","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91353076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Şenat, Soner Yesilyurt, Osman Erinc, Ayşegül OĞLAKÇI İLHAN
Abstract Introduction: The effects of 25-hydroxyvitamin D (25(OH) D) on inflammation are gaining attention, particularly for diabetic individuals with COVID-19. Therefore, we examined 25(OH) D and inflammation-related markers in diabetic subjects with mild COVID-19. Materials and Methods: This investigation was intended to be retrospective. The present study covered the medical records of patients who applied to the our hospital between March 2020 and November 2022. All patients suffer from COVID-19. The control group (n = 30) had no diabetes, while the study group (n = 36) had diabetes. Inflammatory markers such as ferritin, C-reactive protein and erythrocyte sedimentation rate were measured in addition to 25 (OH) D levels in each subject. Also, the results of the complete blood count were obtained from the hospital database. Results: Our participants were matched in terms of gender and age between study groups. ESR, CRP, ferritin, and 25 (OH) D levels, among other variables, did not significantly differ between the non-DM and DM groups (p>0.05). Also, we evaluated all participants according to deficiency of 25 (OH) D, and inflammatory markers were not evaluated in diabetic subjects with COVID-19. However, our findings showed that ferritin levels and Hba1c levels in diabetic individuals significantly correlated positively. Conclusion: Diabetes mellitus and deficiency of 25 (OH) D are known as risk factors for COVID-19. But as compared to non-diabetic participants with COVID-19, our findings did not reveal any considerable elevation neither inflammatory markers nor changes 25 (OH) D in the diabetics.
{"title":"An Assessment of 25-hydroxyvitamin D Levels and Inflammation Markers in Diabetic Patients with Mild COVID-19","authors":"A. Şenat, Soner Yesilyurt, Osman Erinc, Ayşegül OĞLAKÇI İLHAN","doi":"10.31832/smj.1322235","DOIUrl":"https://doi.org/10.31832/smj.1322235","url":null,"abstract":"Abstract \u0000Introduction: The effects of 25-hydroxyvitamin D (25(OH) D) on inflammation are gaining attention, particularly for diabetic individuals with COVID-19. Therefore, we examined 25(OH) D and inflammation-related markers in diabetic subjects with mild COVID-19. \u0000Materials and Methods: This investigation was intended to be retrospective. The present study covered the medical records of patients who applied to the our hospital between March 2020 and November 2022. All patients suffer from COVID-19. The control group (n = 30) had no diabetes, while the study group (n = 36) had diabetes. Inflammatory markers such as ferritin, C-reactive protein and erythrocyte sedimentation rate were measured in addition to 25 (OH) D levels in each subject. Also, the results of the complete blood count were obtained from the hospital database. \u0000Results: Our participants were matched in terms of gender and age between study groups. ESR, CRP, ferritin, and 25 (OH) D levels, among other variables, did not significantly differ between the non-DM and DM groups (p>0.05). Also, we evaluated all participants according to deficiency of 25 (OH) D, and inflammatory markers were not evaluated in diabetic subjects with COVID-19. However, our findings showed that ferritin levels and Hba1c levels in diabetic individuals significantly correlated positively. \u0000Conclusion: Diabetes mellitus and deficiency of 25 (OH) D are known as risk factors for COVID-19. But as compared to non-diabetic participants with COVID-19, our findings did not reveal any considerable elevation neither inflammatory markers nor changes 25 (OH) D in the diabetics.","PeriodicalId":21405,"journal":{"name":"Sakarya Medical Journal","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88546217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Altınkaynak, Yağmur GÖKSOY SOLAK, N. Senkal, Y. Tor, T. Akpınar, Murat Kose
Amaç Glikagon benzeri peptit-1 (GLP-1) analoğu olan liraglutidin diyabetten bağımsız olarak obezite tedavisinde kullanımı onaylanmıştır. Çalışmamızda liraglutidin obezite tedavisinde etkinliğini araştırıldı. Yöntem ve Gereçler 2018-2021 yılları arasında genel dahiliye polikliniğine başvuran fazla kilolu ve obez, 18 yaş üzeri hastaların dosyaları incelendi. Tıbbi beslenme tedavisi ve egzersiz programına ile liraglutide 3 mg/gün en az bir ay alan hastalar çalışmaya alındı. Hastalar liraglutide kullanım sürelerine göre ayrılarak vücut kitle indeksi (VKİ), ilaç etkinliği ve yan etkileri her ay değerlendirildi. Bulgular Çalışmamıza 201 kadın ortalama 40,9±10,5 yaş 303 hasta alındı. Hastaların VKİ dağılımına bakıldığında 80 hasta (%26,4) aşırı kilolu, 128 hasta (%42,2) evre 1 obezite, 61 hasta (%20,1) evre 2 obesite, 34 hasta (%11,2) ise evre 3 obezite olarak değerlendirildi. Liraglutide tedavisini 233 hasta 1-4 ay, 59 hasta 5-8 ay ve 11 hasta ise ≥9 ay süre ile kullandı. Bu grupların ortalama ortalama yaşı sırasıyla 41,2±10,5; 39,8±10,9 ve 40,2±10,4 ortalama VKİ’si 34,3±2,4 kg/m2; 33,9±4,2 kg/m2 ve 39,5±5,1 kg/m2 saptandı. Ortalama kilo kaybı ise sırasıyla 6,4 kg; 12,5 kg ve 21 kg saptandı. Her üç grupta da başlangıç kilosuna göre anlamlı kilo kaybı gözlendi (p
{"title":"Investigation of the Effectiveness of Liraglutide in the Medical Treatment of Obesity","authors":"M. Altınkaynak, Yağmur GÖKSOY SOLAK, N. Senkal, Y. Tor, T. Akpınar, Murat Kose","doi":"10.31832/smj.1320355","DOIUrl":"https://doi.org/10.31832/smj.1320355","url":null,"abstract":"Amaç Glikagon benzeri peptit-1 (GLP-1) analoğu olan liraglutidin diyabetten bağımsız olarak obezite tedavisinde kullanımı onaylanmıştır. Çalışmamızda liraglutidin obezite tedavisinde etkinliğini araştırıldı. \u0000Yöntem ve Gereçler 2018-2021 yılları arasında genel dahiliye polikliniğine başvuran fazla kilolu ve obez, 18 yaş üzeri hastaların dosyaları incelendi. Tıbbi beslenme tedavisi ve egzersiz programına ile liraglutide 3 mg/gün en az bir ay alan hastalar çalışmaya alındı. Hastalar liraglutide kullanım sürelerine göre ayrılarak vücut kitle indeksi (VKİ), ilaç etkinliği ve yan etkileri her ay değerlendirildi. \u0000Bulgular Çalışmamıza 201 kadın ortalama 40,9±10,5 yaş 303 hasta alındı. Hastaların VKİ dağılımına bakıldığında 80 hasta (%26,4) aşırı kilolu, 128 hasta (%42,2) evre 1 obezite, 61 hasta (%20,1) evre 2 obesite, 34 hasta (%11,2) ise evre 3 obezite olarak değerlendirildi. Liraglutide tedavisini 233 hasta 1-4 ay, 59 hasta 5-8 ay ve 11 hasta ise ≥9 ay süre ile kullandı. Bu grupların ortalama ortalama yaşı sırasıyla 41,2±10,5; 39,8±10,9 ve 40,2±10,4 ortalama VKİ’si 34,3±2,4 kg/m2; 33,9±4,2 kg/m2 ve 39,5±5,1 kg/m2 saptandı. Ortalama kilo kaybı ise sırasıyla 6,4 kg; 12,5 kg ve 21 kg saptandı. Her üç grupta da başlangıç kilosuna göre anlamlı kilo kaybı gözlendi (p","PeriodicalId":21405,"journal":{"name":"Sakarya Medical Journal","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89165666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: The study aimed at identifying dangers and risks encountered by hazelnut farm workers and exploring the effect of occupational health and safety training about hazelnut farming upon the workers’ knowledge level. Materials and Methods: In this research, which was conducted as an intervention study, the pre-test post-test single-group research pattern was used. Training and brochures were given to 60 hazelnut agriculture employees selected using a random sampling method after the pretest. The change in the current knowledge score was examined statistically with the last test application two weeks later. Results: 53.3% of the participants were male and their average age was 43.0±14.4 years. 60.0% of the participants stated that they had accidents while they were engaged in hazelnut farming and 71.7% of them did not have any training about occupational health and safety previously. Participants’ score of knowledge about physical dangers and risks as to occupational health and safety was 62.7±17.8 before the training while it significantly increased to 79.3±16.3 after the training. It was seen that after the training held; having a previous training, having high educational status, having no accidents previously and being at a young age affected post-test scores significantly. Conclusion: In the study, it was explored that hazelnut farming workers in Trabzon Province lacked knowledge about physical and ergonomic risks in relation to occupational health and safety. For the trainings of the workers; universities, provincial and district directorates of agriculture and agriculture cooperatives can be used.
{"title":"The Effect of Occupational Health and Safety Education on Hazelnut Agriculture Workers' Knowledge Levels Related to Physical and Ergonomic Hazards","authors":"Oğuzhan Tiryaki, Gamze Çan, M. Topbaş, N. Beyhun","doi":"10.31832/smj.1260269","DOIUrl":"https://doi.org/10.31832/smj.1260269","url":null,"abstract":"Objective: The study aimed at identifying dangers and risks encountered by hazelnut farm workers and exploring the effect of occupational health and safety training about hazelnut farming upon the workers’ knowledge level. \u0000Materials and Methods: In this research, which was conducted as an intervention study, the pre-test post-test single-group research pattern was used. Training and brochures were given to 60 hazelnut agriculture employees selected using a random sampling method after the pretest. The change in the current knowledge score was examined statistically with the last test application two weeks later. \u0000Results: 53.3% of the participants were male and their average age was 43.0±14.4 years. 60.0% of the participants stated that they had accidents while they were engaged in hazelnut farming and 71.7% of them did not have any training about occupational health and safety previously. Participants’ score of knowledge about physical dangers and risks as to occupational health and safety was 62.7±17.8 before the training while it significantly increased to 79.3±16.3 after the training. It was seen that after the training held; having a previous training, having high educational status, having no accidents previously and being at a young age affected post-test scores significantly. \u0000Conclusion: In the study, it was explored that hazelnut farming workers in Trabzon Province lacked knowledge about physical and ergonomic risks in relation to occupational health and safety. For the trainings of the workers; universities, provincial and district directorates of agriculture and agriculture cooperatives can be used.","PeriodicalId":21405,"journal":{"name":"Sakarya Medical Journal","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85651460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amaç: Bu çalışmanın amacı nörobiyoloji çalışmalarında sıkça kullanılmakta olan HT22 fare hipokampal hücre hattının nöronal farklılaşma modeli olarak kullanılabilirliğinin anlaşılması için standart bir farklandırma besiyerine farklı sürelerde verdiği apoptotik cevabın sınanmasıdır. Gereç ve Yöntemler: HT22 hücrelerinin ekilmesi ve farklandırma dışında kültüre edilmesi için HG-DMEM farklandırma için ise B27+ katkılı NB+ medyumu kullanılmıştır. Kontrol grubu da dâhil olmak üzere toplam 9 farklı grup standart olarak kültüre edilmiştir. Deney sonunda AnnexinV/PI işaretlemesiyle erken/geç apoptozis ve nekrozis oranları akım sitometrik olarak belirlenmiştir. Verilerin normal dağılıma uyup uymadığı Shapiro-Wilks testi ile sınandıktan sonra en uygun testle istatistiksel analiz gerçekleştirilmiştir. Bulgular: Gruplar arasındaki karşılaştırmada erken apoptozis (P
{"title":"HT22 Fare Hipokampal Hücre Hattının Nöronal Farklanma Besiyerine Verdiği Apoptotik Tepkinin Ölçülmesi","authors":"Ayla BATU ÖZTÜRK, Derya Yetki̇n, Nail Can Öztürk","doi":"10.31832/smj.1264019","DOIUrl":"https://doi.org/10.31832/smj.1264019","url":null,"abstract":"Amaç: Bu çalışmanın amacı nörobiyoloji çalışmalarında sıkça kullanılmakta olan HT22 fare hipokampal hücre hattının nöronal farklılaşma modeli olarak kullanılabilirliğinin anlaşılması için standart bir farklandırma besiyerine farklı sürelerde verdiği apoptotik cevabın sınanmasıdır. \u0000 \u0000Gereç ve Yöntemler: HT22 hücrelerinin ekilmesi ve farklandırma dışında kültüre edilmesi için HG-DMEM farklandırma için ise B27+ katkılı NB+ medyumu kullanılmıştır. Kontrol grubu da dâhil olmak üzere toplam 9 farklı grup standart olarak kültüre edilmiştir. Deney sonunda AnnexinV/PI işaretlemesiyle erken/geç apoptozis ve nekrozis oranları akım sitometrik olarak belirlenmiştir. Verilerin normal dağılıma uyup uymadığı Shapiro-Wilks testi ile sınandıktan sonra en uygun testle istatistiksel analiz gerçekleştirilmiştir. \u0000 \u0000Bulgular: Gruplar arasındaki karşılaştırmada erken apoptozis (P","PeriodicalId":21405,"journal":{"name":"Sakarya Medical Journal","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77198417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: In this study, we aimed to compare the attachment styles and emotion regulation difficulties of adolescents with psychiatric disorders and healthy adolescents, and to examine the factors affecting attachment styles and emotion regulation difficulties. Material-methods: In this case-control study, DSM-5 diagnostic system was used for psychiatric diagnoses of adolescents, Difficulties in Emotion Regulation Scale-Short Form (DERS-SF) was used to measure adolescents' levels of emotional dysregulation, and Relationships Scales Questionnaire(RSQ) was used to assess attachment styles. Results: Major depressive disorder (MDD) (42.9%) was the most common psychiatric diagnosis. The lowest DERS-SF total score and the highest secure attachment were found in the control group (p
{"title":"Ergenlerdeki bağlanma stilleri ve duygu düzenleme güçlükleri ile psikiyatrik bozuklukları arasındaki ilişki","authors":"Dilşad YILDIZ MİNİKSAR, Mahmut Kiliç","doi":"10.31832/smj.1288608","DOIUrl":"https://doi.org/10.31832/smj.1288608","url":null,"abstract":"Introduction: In this study, we aimed to compare the attachment styles and emotion regulation difficulties of adolescents with psychiatric disorders and healthy adolescents, and to examine the factors affecting attachment styles and emotion regulation difficulties. \u0000Material-methods: In this case-control study, DSM-5 diagnostic system was used for psychiatric diagnoses of adolescents, Difficulties in Emotion Regulation Scale-Short Form (DERS-SF) was used to measure adolescents' levels of emotional dysregulation, and Relationships Scales Questionnaire(RSQ) was used to assess attachment styles. \u0000Results: Major depressive disorder (MDD) (42.9%) was the most common psychiatric diagnosis. The lowest DERS-SF total score and the highest secure attachment were found in the control group (p","PeriodicalId":21405,"journal":{"name":"Sakarya Medical Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83362179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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