Sertralin, antidepresan ve anksiyolitik özellikleri olan pek çok ruhsal bozukluğun tedavisinde kullanılabilen seçici serotonin geri alım inhibitörü (SSGI) grubundan bir antidepresandır. Sertraline bağlı nadir görülen yan etki kanama eğiliminin artmasıdır. Bu yazıda sertralin kullanımıyla başlayan ve ilacın kesilmesinin ardından kaybolan sertalin kullanımı ile ilişkili ekimoz olgusu sunulmuştur.
{"title":"Sertralin Kullanımı İlişkili Ekimoz: Olgu Sunumu","authors":"Müsemma Bolat, Bilal Bolat, Rana Sari̇, Erkut Etçi̇oğlu","doi":"10.31832/smj.1306018","DOIUrl":"https://doi.org/10.31832/smj.1306018","url":null,"abstract":"Sertralin, antidepresan ve anksiyolitik özellikleri olan pek çok ruhsal bozukluğun tedavisinde kullanılabilen seçici serotonin geri alım inhibitörü (SSGI) grubundan bir antidepresandır. Sertraline bağlı nadir görülen yan etki kanama eğiliminin artmasıdır. Bu yazıda sertralin kullanımıyla başlayan ve ilacın kesilmesinin ardından kaybolan sertalin kullanımı ile ilişkili ekimoz olgusu sunulmuştur.","PeriodicalId":21405,"journal":{"name":"Sakarya Medical Journal","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84014266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Differentiating high-grade neuroendocrine carcinomas (HGNEC) is difficult. We aimed to assess the clinical features and survival outcomes of unclassified HGNEC (uHGNEC) and to compare it with small-cell lung cancer (SCLC). Material and Methods: This was a retrospective and observational study of HGNEC patients. Kaplan-Meier method was used to estimate progression-free survival (PFS) and overall survival (OS). Cox-regression analyses were used to determine the risk factors independently associated with PFS and OS. Results: One hundred twenty-one patients [uHGNEC (n = 35), SCLC (n = 86)] were analysed. The primary tumour was mostly right-sided, located in the centre of the lungs. The IASLC stage at diagnosis was locally advanced in 43 (35.5%) patients and advanced in 78 (64.5%) patients. uHGNEC and SCLC groups shared similar clinical features. The study population's median PFS and OS were 8.8 (95%Cl 7.29 – 10.30) and 10.9 (95%Cl 9.9 – 11.8) months, respectively. uHGNEC- and SCLC groups had a similar PFS (9.4 vs 8.6 months, p = 0.99) and OS (12 vs 10.7 months, p = 0.51). The six-month, one- and two-year PFS and OS of two groups were also similar. Among all patients, a right-sided tumour (HR: 1.558, 95%Cl 1.044 – 2.325, p = 0.03) and advanced-stage disease (HR: 1.928, 95%Cl 1.292 – 2.877, p = 0.001) were prognostic factors for poor OS. Cox-regression analysis indicated that histopathology did not have an impact on PFS and OS. Conclusion: HGNEC patients who cannot be classified pathologically behave like SCLC.
{"title":"Sınıflandırılamayan akciğer yüksek dereceli nöroendokrin karsinomaların klinik özellikleri ve sağ kalım sonuçları","authors":"Yasemin Söyler, Pınar AKIN KABALAK, Suna Kavurgacı, Funda Demi̇rağ, Ülkü Yilmaz","doi":"10.31832/smj.1277259","DOIUrl":"https://doi.org/10.31832/smj.1277259","url":null,"abstract":"Background: Differentiating high-grade neuroendocrine carcinomas (HGNEC) is difficult. We aimed to assess the clinical features and survival outcomes of unclassified HGNEC (uHGNEC) and to compare it with small-cell lung cancer (SCLC). \u0000Material and Methods: This was a retrospective and observational study of HGNEC patients. Kaplan-Meier method was used to estimate progression-free survival (PFS) and overall survival (OS). Cox-regression analyses were used to determine the risk factors independently associated with PFS and OS. \u0000Results: One hundred twenty-one patients [uHGNEC (n = 35), SCLC (n = 86)] were analysed. The primary tumour was mostly right-sided, located in the centre of the lungs. The IASLC stage at diagnosis was locally advanced in 43 (35.5%) patients and advanced in 78 (64.5%) patients. uHGNEC and SCLC groups shared similar clinical features. The study population's median PFS and OS were 8.8 (95%Cl 7.29 – 10.30) and 10.9 (95%Cl 9.9 – 11.8) months, respectively. uHGNEC- and SCLC groups had a similar PFS (9.4 vs 8.6 months, p = 0.99) and OS (12 vs 10.7 months, p = 0.51). The six-month, one- and two-year PFS and OS of two groups were also similar. Among all patients, a right-sided tumour (HR: 1.558, 95%Cl 1.044 – 2.325, p = 0.03) and advanced-stage disease (HR: 1.928, 95%Cl 1.292 – 2.877, p = 0.001) were prognostic factors for poor OS. Cox-regression analysis indicated that histopathology did not have an impact on PFS and OS. \u0000Conclusion: HGNEC patients who cannot be classified pathologically behave like SCLC.","PeriodicalId":21405,"journal":{"name":"Sakarya Medical Journal","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76151137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Erel İçel, Nergis Akbaş, E. Akbaş, Aykut İçel, Y. Arslan
Amaç: Bu çalışmada, obez hastalarda retinal mikrovasküler yapısında meydana gelen değişiklikleri değerlendirmeyi ve bu değişikliklerin klinik özelliklerle ilişkisini belirlemeyi amaçladık. Gereç ve Yöntemler: Tüm katılımcılarda kolesterol, açlık kan şekeri, açlık insülini,CRP ve HbA1C düzeylerini içeren biyokimyasal incelemeler yapıldı. Plazma aterojenik indeksi(AI) plazma trigliserid (TG) düzeyinin yüksek yoğunluklu lipoprotein (HDL) düzeyine oranının logaritması [log (TG/HDL-K)] olarak hesaplandı. Vücut Kitle İndeksi (VKİ) ≤25 kg/m2 olan hastalar kontrol grubuna dahil edildi. Obez hastalar VKİ'lerine göre üç gruba ayrıldı: grup 1 (VKİ: 30-34,99 kg/m2), grup 2 (VKİ: 35-39.99 kg/m2) ve grup 3 (VKİ ≥ 40 kg/m2) . Optik koherens tomografi anjiografi (OKT-A) ile foveal avasküler zon (FAZ), makulada yüzeyel ve derin kapiller pleksusun damar dansitesi (VD) ile radial peripapiller kapiller pleksus VD ölçüldü. Bulgular: Çalışmaya 27 kontrol ve 83 obez hasta olmak üzere toplam 110 hasta dahil edildi. Kontrol vakalarına kıyasla obez hastalarda HbA1C, açlık insülini, HOMA-IR, C-reaktif protein ve AI seviyeleri anlamlı derecede yüksekti. Obez hastalarda retinanın yüzeyel (p=0,003) ve derin (p=0,001)VD'leri anlamlı olarak azaldı ve FAZ anlamlı olarak arttı (p=0,032). Klinik özellikler ile OKT-A bulguları arasında yapılan korelasyon analizinde yüzeyel ve derin VD'ler yaş, VKİ, HbA1C ve AI ile ters orantılıydı. Sonuç: Obez hastalarda retina yüzeyel ve derin VD'leri azalmıştı ve retinal VD'ler ile yaş, VKI, HbA1C ve AI arasında ters bir ilişki vardı.
{"title":"OBEZ HASTALARDA BEDEN KİTLE İNDEKSİ VE ATEROJENİK İNDEKSİN RETINAL MİKROVASKÜLER YAPI ÜZERİNE ETKİLERİ","authors":"Erel İçel, Nergis Akbaş, E. Akbaş, Aykut İçel, Y. Arslan","doi":"10.31832/smj.1260292","DOIUrl":"https://doi.org/10.31832/smj.1260292","url":null,"abstract":"Amaç: Bu çalışmada, obez hastalarda retinal mikrovasküler yapısında meydana gelen değişiklikleri değerlendirmeyi ve bu değişikliklerin klinik özelliklerle ilişkisini belirlemeyi amaçladık. \u0000Gereç ve Yöntemler: Tüm katılımcılarda kolesterol, açlık kan şekeri, açlık insülini,CRP ve HbA1C düzeylerini içeren biyokimyasal incelemeler yapıldı. Plazma aterojenik indeksi(AI) plazma trigliserid (TG) düzeyinin yüksek yoğunluklu lipoprotein (HDL) düzeyine oranının logaritması [log (TG/HDL-K)] olarak hesaplandı. Vücut Kitle İndeksi (VKİ) ≤25 kg/m2 olan hastalar kontrol grubuna dahil edildi. Obez hastalar VKİ'lerine göre üç gruba ayrıldı: grup 1 (VKİ: 30-34,99 kg/m2), grup 2 (VKİ: 35-39.99 kg/m2) ve grup 3 (VKİ ≥ 40 kg/m2) . Optik koherens tomografi anjiografi (OKT-A) ile foveal avasküler zon (FAZ), makulada yüzeyel ve derin kapiller pleksusun damar dansitesi (VD) ile radial peripapiller kapiller pleksus VD ölçüldü. \u0000Bulgular: Çalışmaya 27 kontrol ve 83 obez hasta olmak üzere toplam 110 hasta dahil edildi. Kontrol vakalarına kıyasla obez hastalarda HbA1C, açlık insülini, HOMA-IR, C-reaktif protein ve AI seviyeleri anlamlı derecede yüksekti. Obez hastalarda retinanın yüzeyel (p=0,003) ve derin (p=0,001)VD'leri anlamlı olarak azaldı ve FAZ anlamlı olarak arttı (p=0,032). Klinik özellikler ile OKT-A bulguları arasında yapılan korelasyon analizinde yüzeyel ve derin VD'ler yaş, VKİ, HbA1C ve AI ile ters orantılıydı. \u0000Sonuç: Obez hastalarda retina yüzeyel ve derin VD'leri azalmıştı ve retinal VD'ler ile yaş, VKI, HbA1C ve AI arasında ters bir ilişki vardı.","PeriodicalId":21405,"journal":{"name":"Sakarya Medical Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89853409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: In this study, it was aimed to investigate hematological parameters according to thyroid stimulating hormone (TSH) levels in thyroid patients. Materials and Methods: Thyroid function tests and hemogram data of 5130 thyroid patients admitted to our hospital between January 2019 and August 2021 were analyzed retrospectively. Results: There was no significant difference between hemoglobin, MCH, leukocyte, basophil and thrombocyte levels according to TSH levels. When compared in terms of MCV, a significant difference was found between group 1 (TSH
{"title":"Analysis of Hematological Parameters According to TSH Levels in Thyroid Patients","authors":"S. Yaylacı, T. Demirci, Mehmet Özdi̇n","doi":"10.31832/smj.1019576","DOIUrl":"https://doi.org/10.31832/smj.1019576","url":null,"abstract":"Objective: In this study, it was aimed to investigate hematological parameters according to thyroid stimulating hormone (TSH) levels in thyroid patients. \u0000Materials and Methods: Thyroid function tests and hemogram data of 5130 thyroid patients admitted to our hospital between January 2019 and August 2021 were analyzed retrospectively. \u0000Results: There was no significant difference between hemoglobin, MCH, leukocyte, basophil and thrombocyte levels according to TSH levels. When compared in terms of MCV, a significant difference was found between group 1 (TSH","PeriodicalId":21405,"journal":{"name":"Sakarya Medical Journal","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77911977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Acibuca, A. Uçar, A. Sümbül, A. Sezer, Ş. Demircan, H. Müderrisoğlu, Ö. Özyi̇lkan
Pertuzumab-mediated Cardiotoxicity: A Single Center Study. Objective: Recent clinical trials have shown that adding pertuzumab to trastuzumab improved the cellular response to therapy and provides a survival benefit compared with trastuzumab alone. However, it has raised concerns about additive risk of cardiotoxicity. Real life data on pertuzumab-induced cardiotoxicity are limited. Materials and Methods: Patients a diagnosis of breast cancer who had been treated trastuzumab plus pertuzumab between January 2017 and June 2022 and had undergone regularly transthoracic echocardiography, as a part of control visits, in our medical center were included. We performed descriptive statistical analysis to evaluate the patients’ characteristics and therapies, which could increase the risk of cardiac adverse events. Cardiotoxicity was evaluated by serial left ventricular ejection fraction (LVEF) measuring by 2D echocardiography at baseline and every three months during pertuzumab therapy and was defined as a decrease in LVEF > 10% to below 55%. Results: There were 118 patients fulfilling the inclusion criteria. The median age of the population was 51 (41-60) years. The median duration of pertuzumab therapy was 15 (9–57) weeks. Pertuzumab therapy was discontinued in two patients because of an allergic reaction and in other two patients due to cardiotoxicity. The reduced LVEF did not recover to baseline values in either patient. Conclusion: The incidence of cardiotoxicity (1.69%) in the current study was no higher than expected for trastuzumab alone. Data from previous studies and the results of this study support that pertuzumab causes no increase in cardiotoxicity. Still, large clinical trials are needed to verify the cardiac safety of pertuzumab in a real-world setting.
{"title":"Pertuzumab-mediated Cardiotoxicity: A Single Center Study.","authors":"A. Acibuca, A. Uçar, A. Sümbül, A. Sezer, Ş. Demircan, H. Müderrisoğlu, Ö. Özyi̇lkan","doi":"10.31832/smj.1163527","DOIUrl":"https://doi.org/10.31832/smj.1163527","url":null,"abstract":"Pertuzumab-mediated Cardiotoxicity: A Single Center Study. \u0000Objective: Recent clinical trials have shown that adding pertuzumab to trastuzumab improved the cellular response to therapy and provides a survival benefit compared with trastuzumab alone. However, it has raised concerns about additive risk of cardiotoxicity. Real life data on pertuzumab-induced cardiotoxicity are limited. \u0000Materials and Methods: Patients a diagnosis of breast cancer who had been treated trastuzumab plus pertuzumab between January 2017 and June 2022 and had undergone regularly transthoracic echocardiography, as a part of control visits, in our medical center were included. We performed descriptive statistical analysis to evaluate the patients’ characteristics and therapies, which could increase the risk of cardiac adverse events. Cardiotoxicity was evaluated by serial left ventricular ejection fraction (LVEF) measuring by 2D echocardiography at baseline and every three months during pertuzumab therapy and was defined as a decrease in LVEF > 10% to below 55%. \u0000Results: There were 118 patients fulfilling the inclusion criteria. The median age of the population was 51 (41-60) years. The median duration of pertuzumab therapy was 15 (9–57) weeks. Pertuzumab therapy was discontinued in two patients because of an allergic reaction and in other two patients due to cardiotoxicity. The reduced LVEF did not recover to baseline values in either patient. \u0000Conclusion: The incidence of cardiotoxicity (1.69%) in the current study was no higher than expected for trastuzumab alone. Data from previous studies and the results of this study support that pertuzumab causes no increase in cardiotoxicity. Still, large clinical trials are needed to verify the cardiac safety of pertuzumab in a real-world setting.","PeriodicalId":21405,"journal":{"name":"Sakarya Medical Journal","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90327479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amet Çağrı Uyar, Alauddin Kochai̇, Mustafa Uysal, Abdülhalim Akar, Uğur Özdemi̇r
Objective: The aim of this study is to define the ideal surgical treatment option for distal humerus fractures by comparing different surgical techniques. Material and methods: Seventy-one patients with distal humerus diaphysis fractures who were treated between 2015 and 2020 were retrospectively investigated,. The patients were operated on with the posterior approach of open reduction and plate-screw osteosynthesis (Group A), plated with the minimal invasive technique (Group B), operated on using the lateral approach (Group C) and treated with an external fixator (Group D). Age, gender, mechanism of fracture, fracture type and AO class, applied surgical method, additional injuries, duration of operation, amount of bleeding, amount of fluoroscopy used, length of hospital stay, radiological angular values, union time, complications, and clinical examination findings of the patients were examined retrospectively and the differences between the mentioned surgical methods were investigated. Results: Blood loss was significantly less in Groups C and D (p
{"title":"Erişkin distal humerus kompleks kırıklarında ideal cerrahi tedavi seçeneği var mı?","authors":"Amet Çağrı Uyar, Alauddin Kochai̇, Mustafa Uysal, Abdülhalim Akar, Uğur Özdemi̇r","doi":"10.31832/smj.1190747","DOIUrl":"https://doi.org/10.31832/smj.1190747","url":null,"abstract":"Objective: The aim of this study is to define the ideal surgical treatment option for distal humerus fractures by comparing different surgical techniques. \u0000 \u0000Material and methods: Seventy-one patients with distal humerus diaphysis fractures who were treated between 2015 and 2020 were retrospectively investigated,. The patients were operated on with the posterior approach of open reduction and plate-screw osteosynthesis (Group A), plated with the minimal invasive technique (Group B), operated on using the lateral approach (Group C) and treated with an external fixator (Group D). Age, gender, mechanism of fracture, fracture type and AO class, applied surgical method, additional injuries, duration of operation, amount of bleeding, amount of fluoroscopy used, length of hospital stay, radiological angular values, union time, complications, and clinical examination findings of the patients were examined retrospectively and the differences between the mentioned surgical methods were investigated. \u0000 \u0000Results: Blood loss was significantly less in Groups C and D (p","PeriodicalId":21405,"journal":{"name":"Sakarya Medical Journal","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85310619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: It is very important to identify individuals at high risk of atherosclerotic cardiovascular diseases (ASCVD) and for this purpose, many risk calculation tools and parameters are used. In this study, we aimed to investigate the correlation between the ACC/AHA cardiovascular risk and serum lipid indices and high sensitivity C-reactive protein (hs-CRP) in a healthy population. Methods: Our study was conducted retrospectively on individuals aged between 40 and 79 years and with sufficient data, using the hospital database. Patients with a history of any chronic disease and active infection were excluded. Individuals were analyzed by grouping them into low (5%) estimated 10-year risk of ASCVD. Results: 184 individuals with a median age of 46 and 37.5% women were included in the study. The median 10-year estimated risk of ASCVD in the study population was 3% (1.3/5.98). The low-risk group had a significantly lower atherogenic index of plasma (AIP), Castelli I risk index (CR-I), and Castelli II risk index (CR-II) compared to the borderline to high-risk group (p
{"title":"10-Year Cardiovascular Risk, Serum Lipid Indices and High Sensitivity CRP in a Healthy Population","authors":"S. Akıncı, Ertan Akbay","doi":"10.31832/smj.1166369","DOIUrl":"https://doi.org/10.31832/smj.1166369","url":null,"abstract":"Objective: It is very important to identify individuals at high risk of atherosclerotic cardiovascular diseases (ASCVD) and for this purpose, many risk calculation tools and parameters are used. In this study, we aimed to investigate the correlation between the ACC/AHA cardiovascular risk and serum lipid indices and high sensitivity C-reactive protein (hs-CRP) in a healthy population. \u0000Methods: Our study was conducted retrospectively on individuals aged between 40 and 79 years and with sufficient data, using the hospital database. Patients with a history of any chronic disease and active infection were excluded. Individuals were analyzed by grouping them into low (5%) estimated 10-year risk of ASCVD. \u0000Results: 184 individuals with a median age of 46 and 37.5% women were included in the study. The median 10-year estimated risk of ASCVD in the study population was 3% (1.3/5.98). The low-risk group had a significantly lower atherogenic index of plasma (AIP), Castelli I risk index (CR-I), and Castelli II risk index (CR-II) compared to the borderline to high-risk group (p","PeriodicalId":21405,"journal":{"name":"Sakarya Medical Journal","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75575416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Saadet Çeli̇közlü, Filiz Özyiğit, Said Altikat, S. Köktürk, Halit Çeli̇közlü
Amaç: Bu çalışmanın amacı, sıçanlarda serebral iskemi/reperfüzyon hasarına karşı hesperidinin farklı dozlarının koruyucu etkisini araştırmaktır. Gereç ve Yöntemler: Çalışmada kontrol, sham, iskemi/reperfüzyon (İ/R), hesperidin 50 (Hes 50) ve hesperidin 100 (Hes 100) olmak üzere 5 grup hazırlandı. İskemi oluşturmak için Pulsinelli ve Brierly'nin dört damar oklüzyon modeli kullanıldı. 30 dakika iskemi ve 30 dakika reperfüzyon uygulandı. Hesperidin, iskemiden 30 dakika önce intraperitonal olarak enjekte edildi. Histopatolojik çalışma için beyin dokusuna Golgi Cox ve Caspase 3 boyaması uygulandı. Ayrıca beyin dokusunda SOD, CAT, MDA ve total protein seviyeleri belirlendi ve TNF-α mRNA ekspresyon seviyeleri RT-qPCR tekniği ile ölçüldü. Bulgular: İ/R grubunda kontrol grubuna göre CAT ve SOD değerlerinde azalma, MDA değerinde artış, toplam protein değerinde hafif artış saptandı. Hes 50 ve Hes 100 gruplarında, İ/R grubu ile kıyaslandığında CAT, SOD değerleri arttı, MDA ve toplam protein değerleri önemli ölçüde azaldı. I/R grubunda kontrol grubuna kıyasla önemli bir CA1 nöron kaybı gözlendi. Hes 50 grubunda I/R grubuna göre hipokampustaki nöron hasarının azaldığı ve nöron sayısının istatistiksel olarak anlamlı düzeyde arttığı bulundu. Beyin dokusundaki TNF-α mRNA ekspresyon değerleri, I/R grubunda kontrol ve sham gruplarına göre anlamlı derecede yüksekti. Hes 50 grubunda I/R grubuna kıyasla mRNA ekspresyon miktarında önemli bir azalma gözlendi. Sonuç: Bu çalışmanın sonuçlarına göre, antioksidan potansiyeli olan hesperidin, serebral iskemi/reperfüzyonunun neden olduğu oksidatif stres hasarına karşı nöroprotektif ve antiinflamatuar etkiler göstermiştir. Düşük doz hesperidin (Hes 50) grubunda antiinflamatuar ve nöroprotektif etkiler öne çıkarken, hem Hes 50 hem de Hes 100 gruplarında antioksidan etkinin daha baskın olduğu tespit edilmiştir.
{"title":"Neuroprotective Effects of Hesperidin In Cerebral Ischemia/Reperfusion Injury","authors":"Saadet Çeli̇közlü, Filiz Özyiğit, Said Altikat, S. Köktürk, Halit Çeli̇közlü","doi":"10.31832/smj.1182213","DOIUrl":"https://doi.org/10.31832/smj.1182213","url":null,"abstract":"Amaç: Bu çalışmanın amacı, sıçanlarda serebral iskemi/reperfüzyon hasarına karşı hesperidinin farklı dozlarının koruyucu etkisini araştırmaktır. \u0000Gereç ve Yöntemler: Çalışmada kontrol, sham, iskemi/reperfüzyon (İ/R), hesperidin 50 (Hes 50) ve hesperidin 100 (Hes 100) olmak üzere 5 grup hazırlandı. İskemi oluşturmak için Pulsinelli ve Brierly'nin dört damar oklüzyon modeli kullanıldı. 30 dakika iskemi ve 30 dakika reperfüzyon uygulandı. Hesperidin, iskemiden 30 dakika önce intraperitonal olarak enjekte edildi. Histopatolojik çalışma için beyin dokusuna Golgi Cox ve Caspase 3 boyaması uygulandı. Ayrıca beyin dokusunda SOD, CAT, MDA ve total protein seviyeleri belirlendi ve TNF-α mRNA ekspresyon seviyeleri RT-qPCR tekniği ile ölçüldü. \u0000Bulgular: İ/R grubunda kontrol grubuna göre CAT ve SOD değerlerinde azalma, MDA değerinde artış, toplam protein değerinde hafif artış saptandı. Hes 50 ve Hes 100 gruplarında, İ/R grubu ile kıyaslandığında CAT, SOD değerleri arttı, MDA ve toplam protein değerleri önemli ölçüde azaldı. I/R grubunda kontrol grubuna kıyasla önemli bir CA1 nöron kaybı gözlendi. Hes 50 grubunda I/R grubuna göre hipokampustaki nöron hasarının azaldığı ve nöron sayısının istatistiksel olarak anlamlı düzeyde arttığı bulundu. Beyin dokusundaki TNF-α mRNA ekspresyon değerleri, I/R grubunda kontrol ve sham gruplarına göre anlamlı derecede yüksekti. Hes 50 grubunda I/R grubuna kıyasla mRNA ekspresyon miktarında önemli bir azalma gözlendi. \u0000Sonuç: Bu çalışmanın sonuçlarına göre, antioksidan potansiyeli olan hesperidin, serebral iskemi/reperfüzyonunun neden olduğu oksidatif stres hasarına karşı nöroprotektif ve antiinflamatuar etkiler göstermiştir. Düşük doz hesperidin (Hes 50) grubunda antiinflamatuar ve nöroprotektif etkiler öne çıkarken, hem Hes 50 hem de Hes 100 gruplarında antioksidan etkinin daha baskın olduğu tespit edilmiştir.","PeriodicalId":21405,"journal":{"name":"Sakarya Medical Journal","volume":"616 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77656949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
İsmail Di̇lek, Zehra Hilal Adibelli̇, A. Koc, G. Dal, Esra Koç, A. Argon
ÖZET Amaç: Bu çalışmada, meme manyetik rezonans görüntülemede (MRG) patolojik görünümlü aksiller lenf nodlarının (ALN) MRG ve tekstür analizi (TA) özellikleri kullanılarak, daha önce meme lezyonlarında uygulanan noninvaziv, tekrarlanabilir kantitatif yöntemlerin malign ALN’leri ayırt etmedeki etkinliği araştırılmıştır. Gereç ve yöntemler: Çalışmaya 2018-2020 tarihleri arasında hastanemiz Girişimsel Radyoloji bölümünde ALN’lere yönelik ince iğne aspirasyon biyopsisi ve/veya kesici iğne biyopsisi işlemi yapılan, dinamik kontrastlı ve diffüzyon meme MRG’de patolojik görünümlü ALN’si olan 18 yaş üzeri kadın hastalar dahil edilmiştir. Bulgular: Benign ve malign lenf nodları arasında T2A yağlı hilus varlığı açısından istatistiksel olarak anlamlı farklılık vardı (p=0,008). MR tekstür analizi sonuçlarının değerlendirilmesinde; benign ve malign grupta T2 area ve T2 skewness değerleri arasında (sırasıyla p=0,006; 0,029), ADC area ve ADC kurtosis değerleri arasında (sırasıyla p=0,027;0,005), postkontrast T1 area, postkontrast T1 variance ve postkontrast T1 kurtosis değerleri arasında ( sırasıyla p=0,036;0,010;
{"title":"Aksiller Lenf Bezlerinin Manyetik Rezonans Görüntüleme (MRG) Tekstür Analizi Sonuçlarının Patoloji Sonuçları ile Karşılaştırılması","authors":"İsmail Di̇lek, Zehra Hilal Adibelli̇, A. Koc, G. Dal, Esra Koç, A. Argon","doi":"10.31832/smj.1259313","DOIUrl":"https://doi.org/10.31832/smj.1259313","url":null,"abstract":"ÖZET \u0000Amaç: Bu çalışmada, meme manyetik rezonans görüntülemede (MRG) patolojik görünümlü aksiller lenf nodlarının (ALN) MRG ve tekstür analizi (TA) özellikleri kullanılarak, daha önce meme lezyonlarında uygulanan noninvaziv, tekrarlanabilir kantitatif yöntemlerin malign ALN’leri ayırt etmedeki etkinliği araştırılmıştır. \u0000Gereç ve yöntemler: Çalışmaya 2018-2020 tarihleri arasında hastanemiz Girişimsel Radyoloji bölümünde ALN’lere yönelik ince iğne aspirasyon biyopsisi ve/veya kesici iğne biyopsisi işlemi yapılan, dinamik kontrastlı ve diffüzyon meme MRG’de patolojik görünümlü ALN’si olan 18 yaş üzeri kadın hastalar dahil edilmiştir. \u0000Bulgular: Benign ve malign lenf nodları arasında T2A yağlı hilus varlığı açısından istatistiksel olarak anlamlı farklılık vardı (p=0,008). MR tekstür analizi sonuçlarının değerlendirilmesinde; benign ve malign grupta T2 area ve T2 skewness değerleri arasında (sırasıyla p=0,006; 0,029), ADC area ve ADC kurtosis değerleri arasında (sırasıyla p=0,027;0,005), postkontrast T1 area, postkontrast T1 variance ve postkontrast T1 kurtosis değerleri arasında ( sırasıyla p=0,036;0,010;","PeriodicalId":21405,"journal":{"name":"Sakarya Medical Journal","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89246677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: This study aims to investigate the relationship between smokeless tobacco (Maras powder) and cigarette consumption with homocysteine, Paraoxonase-1 (PON-1), Arylesterase (ARE), and Lipoprotein-a (Lp (a)), which are known as risk factors for cardiovascular diseases. Material and Methods: The individuals included in the study were divided into three groups as Maras powder users (n = 38), cigarette smokers (n = 38), and healthy volunteers who did not use either tobacco group (n = 38). Serum homocysteine, PON-1, ARE, and Lp (a) levels of all participants were examined. Results: When the groups are compared, the highest homocysteine level was in the Maras powder group. While the difference between the control group and the Maras powder group was statistically significant, the difference between the control and smokers groups was statistically insignificant. Although PON values were lower in both the Maras powder and smokers groups than the control group, the difference was significant only in the smoking group. ARE was significantly lower, and Lp (a) was significantly higher in both tobacco smokers groups compared to the control group. Conclusion: Serum homocysteine, PON-1, ARE, and Lp (a) level are associated with Maras powder use. Homocysteine may be a useful early marker for cardiovascular disease in those who use Maras powder.
{"title":"Dumansız Tütün \"Maraş Otu\"nun Homosistein ve Kardiyovasküler Risk Parametreleri Üzerine Etkileri","authors":"Filiz ALKAN BAYLAN, E. Yarar, Funda Cansun, Adem Doğaner, Gülizar Sökmen","doi":"10.31832/smj.1159218","DOIUrl":"https://doi.org/10.31832/smj.1159218","url":null,"abstract":"Objective: This study aims to investigate the relationship between smokeless tobacco (Maras powder) and cigarette consumption with homocysteine, Paraoxonase-1 (PON-1), Arylesterase (ARE), and Lipoprotein-a (Lp (a)), which are known as risk factors for cardiovascular diseases. \u0000Material and Methods: The individuals included in the study were divided into three groups as Maras powder users (n = 38), cigarette smokers (n = 38), and healthy volunteers who did not use either tobacco group (n = 38). Serum homocysteine, PON-1, ARE, and Lp (a) levels of all participants were examined. \u0000Results: When the groups are compared, the highest homocysteine level was in the Maras powder group. While the difference between the control group and the Maras powder group was statistically significant, the difference between the control and smokers groups was statistically insignificant. Although PON values were lower in both the Maras powder and smokers groups than the control group, the difference was significant only in the smoking group. ARE was significantly lower, and Lp (a) was significantly higher in both tobacco smokers groups compared to the control group. \u0000Conclusion: Serum homocysteine, PON-1, ARE, and Lp (a) level are associated with Maras powder use. Homocysteine may be a useful early marker for cardiovascular disease in those who use Maras powder.","PeriodicalId":21405,"journal":{"name":"Sakarya Medical Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78986569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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