S. Ösken, A. Içağasioğlu, B. Durmuş, S. Sağ, E. Madenci
Objective: This study aims to determine the frequency of central post-stroke pain (CPSP) in a patient population with stroke as well as investigating the relationship between CPSP and patients' clinical/demographic characteristics, pain intensity, functional status, and quality of life. Methods: The study included 150 patients, who had a stroke and were aged 18 years and above. Demographic data of the patients, time since onset, and etiology, localization of the cerebral lesion, affected side, ambulation status, and Brunnstrom stages were recorded. Douleur neuropathique 4 questions (DN4) were used to assess the presence of CPSP. Visual Analog Scale (VAS) was used for pain intensity, functional ambulation scale (FAS) was used for ambulation status, Barthel Index (BI) was used for functional status, and the stroke impact scale (SIS) was used for quality of life. Results: The mean age of the patients was 67±11.5 years, 54.7% was male, and 45.3% was female. CPSP was evaluated in 15.3% of patients. There was no significant difference between the affected side of the body and age, gender, time since onset, BI scores, and ambulation status of patients according to their CPSP status (p>0.05). There was no statistically significant difference between SIS sub-parameter scores and the presence of CPSP (p>0.05). In correlation analysis, a significant relationship was found between Barthel Indexes and all SIS domains except memory and emotion (p
{"title":"Frequency of Central Post-Stroke Pain and Its Impact on Quality of Life","authors":"S. Ösken, A. Içağasioğlu, B. Durmuş, S. Sağ, E. Madenci","doi":"10.31832/smj.1197365","DOIUrl":"https://doi.org/10.31832/smj.1197365","url":null,"abstract":"Objective: This study aims to determine the frequency of central post-stroke pain (CPSP) in a patient population with stroke as well as investigating the relationship between CPSP and patients' clinical/demographic characteristics, pain intensity, functional status, and quality of life. \u0000Methods: The study included 150 patients, who had a stroke and were aged 18 years and above. Demographic data of the patients, time since onset, and etiology, localization of the cerebral lesion, affected side, ambulation status, and Brunnstrom stages were recorded. Douleur neuropathique 4 questions (DN4) were used to assess the presence of CPSP. Visual Analog Scale (VAS) was used for pain intensity, functional ambulation scale (FAS) was used for ambulation status, Barthel Index (BI) was used for functional status, and the stroke impact scale (SIS) was used for quality of life. \u0000Results: The mean age of the patients was 67±11.5 years, 54.7% was male, and 45.3% was female. CPSP was evaluated in 15.3% of patients. There was no significant difference between the affected side of the body and age, gender, time since onset, BI scores, and ambulation status of patients according to their CPSP status (p>0.05). There was no statistically significant difference between SIS sub-parameter scores and the presence of CPSP (p>0.05). In correlation analysis, a significant relationship was found between Barthel Indexes and all SIS domains except memory and emotion (p","PeriodicalId":21405,"journal":{"name":"Sakarya Medical Journal","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81481789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ahmet Karamustafaoğlu, Seçil Ak Aksoy, B. Tunca, M. Erçelik, Ç. Tekin, N. Uğraş, Ö. Yerci, F. Aksoy, E. Kaya
Introduction: Metastasectomy is one of the effective treatment methods for liver metastases developing from primary colorectal cancer (CRC). However, recurrence after metastasectomy is the biggest problem in these cancers. The present study aimed to examine the role of Epithelial-Mesenchymal Transition (EMT) in the development of recurrence after metastasectomy in liver metastases from primary CRCs. Materials and Methods: In the study, 85 patients were evaluated. RNA was isolated from archive tumors and normal tissues of the patients. Expression profiles of 7 different EMT markers were examined using qRT-PCR. Results: Metastasis to the liver developed in 24.7% (n=21) of 85 CRC. Recurrence was observed in 42.3% (n=9) of liver metastases after metastasectomy. Statistically significant increases were detected in the expression of EMT markers TWIST and SNAIL in the development of mCC in primary CRC (p
{"title":"High SNAIL Expression Reflects Of Recurrence After Resection Colorectal Cancer Liver Metastasis","authors":"Ahmet Karamustafaoğlu, Seçil Ak Aksoy, B. Tunca, M. Erçelik, Ç. Tekin, N. Uğraş, Ö. Yerci, F. Aksoy, E. Kaya","doi":"10.31832/smj.1128434","DOIUrl":"https://doi.org/10.31832/smj.1128434","url":null,"abstract":"Introduction: Metastasectomy is one of the effective treatment methods for liver metastases developing from primary colorectal cancer (CRC). However, recurrence after metastasectomy is the biggest problem in these cancers. \u0000The present study aimed to examine the role of Epithelial-Mesenchymal Transition (EMT) in the development of recurrence after metastasectomy in liver metastases from primary CRCs. \u0000Materials and Methods: In the study, 85 patients were evaluated. RNA was isolated from archive tumors and normal tissues of the patients. Expression profiles of 7 different EMT markers were examined using qRT-PCR. \u0000Results: Metastasis to the liver developed in 24.7% (n=21) of 85 CRC. Recurrence was observed in 42.3% (n=9) of liver metastases after metastasectomy. Statistically significant increases were detected in the expression of EMT markers TWIST and SNAIL in the development of mCC in primary CRC (p","PeriodicalId":21405,"journal":{"name":"Sakarya Medical Journal","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84792792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: The marked variation in the timing of puberty despite similar living conditions shows that many factors are effective in determining the onset of puberty. Many factors, such as genetic and environmental factors, stress, socioeconomic status, metabolic rate, and body fat ratio, affect the age of puberty onset. Recent studies have shown that the age of puberty onset has shifted to earlier ages. The increasing prevalence of childhood obesity is deemed to contribute this change. Therefore, we planned the present study to determine the rates of obesity and overweight, to evaluate the association between obesity, bone age, and height age, and to examine the association between obesity and hormone profile. Materials and Methods: The medical records of 206 patients diagnosed with idiopathic precocious puberty who were being followed up at the Pediatric Endocrinology outpatient clinic of Sakarya Training and Research Hospital between October 2018 and October 2021 were retrospectively reviewed. Anthropometric data (age, gender, height, weight, body mass index, and puberty stage), bone age, height age, and weight age of the patients were recorded from the medical records. Patients were grouped as normal weight, overweight, and obese by body mass index (BMI). Results: Of the included patients, 97.6% (201 patients) were female and 2.4% (5 patients) were male. One hundred and thirty-one patients (63.6%) had normal weight, 40 (19.4%) were overweight and 35 (17%) had obesity. Significant differences were found between the groups (normal weight, overweight and obese) in terms of weight age, BMI percentile, height age, bone age, and bone age standard deviation score (SDS) (p =
{"title":"Evaluation of the association between precocious puberty and obesity","authors":"R. Polat","doi":"10.31832/smj.1204475","DOIUrl":"https://doi.org/10.31832/smj.1204475","url":null,"abstract":"Objective: The marked variation in the timing of puberty despite similar living conditions shows that many factors are effective in determining the onset of puberty. Many factors, such as genetic and environmental factors, stress, socioeconomic status, metabolic rate, and body fat ratio, affect the age of puberty onset. Recent studies have shown that the age of puberty onset has shifted to earlier ages. The increasing prevalence of childhood obesity is deemed to contribute this change. Therefore, we planned the present study to determine the rates of obesity and overweight, to evaluate the association between obesity, bone age, and height age, and to examine the association between obesity and hormone profile. \u0000Materials and Methods: The medical records of 206 patients diagnosed with idiopathic precocious puberty who were being followed up at the Pediatric Endocrinology outpatient clinic of Sakarya Training and Research Hospital between October 2018 and October 2021 were retrospectively reviewed. Anthropometric data (age, gender, height, weight, body mass index, and puberty stage), bone age, height age, and weight age of the patients were recorded from the medical records. Patients were grouped as normal weight, overweight, and obese by body mass index (BMI). \u0000Results: Of the included patients, 97.6% (201 patients) were female and 2.4% (5 patients) were male. One hundred and thirty-one patients (63.6%) had normal weight, 40 (19.4%) were overweight and 35 (17%) had obesity. Significant differences were found between the groups (normal weight, overweight and obese) in terms of weight age, BMI percentile, height age, bone age, and bone age standard deviation score (SDS) (p =","PeriodicalId":21405,"journal":{"name":"Sakarya Medical Journal","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87514635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zerife Orhan, Arzu Kayış, Burak Küçük, Murat Aral, Mehmet Kadir Yanilmaz
Amaç: Bu çalışmada, 2020 yılı içerisinde hastanemizin yoğun bakım üniteleri ve yataklı servislerinden mikrobiyoloji laboratuvarına gönderilen çeşitli kültür örneklerinden izole edilen gram negatif bakteriler ve antibiyotik dirençlerinin retrospektif olarak değerlendirilmesi amaçlanmıştır. Metod: Ocak 2020-Aralık 2020 tarihleri arasında yoğun bakım üniteleri ve yataklı servislerden mikrobiyoloji laboratuvarına gönderilen çeşitli hasta örneklerinden sık izole edilen Gram negatif bakteriler çalışmaya dahil edilmiştir. Bakteri tanımlanması ve antibiyotik duyarlılık testleri konvansiyonel yöntemler ve otomatize sistemler kullanılarak yapılmıştır Bulgular: Bir yıllık süreçte yoğun bakım ünitelerindeki hastalardan sırasıyla %49.7’u endotrakeal aspirat kültürlerinden izole edilen 761 Acinetobacter baumanii, %51.7’si idrar kültüründen izole edilen 478 E. coli, %31.2’si endotrakeal aspirat kültürlerinden izole edilen 417 Klebsiella pneumoniae, %51.5’i endotrakeal aspirat kültürlerinden izole edilen Pseudomonas aeruginosa üremesi olmuştur. Yataklı servislerde ise %47.2’si idrar kültüründen izole edilen 316 Escherichia coli, %43.4’ü idrar kültürlerinden elde edilen 136 Klebsiella pneumoniae, %57.7’si yara kültürlerinden izole edilen 78 Pseudomonas aeruginosa, %60.3’ü yara kültürlerinden izole edilen 68 Acinetobacter baumanii üremesi olmuştur. Yoğun bakımlarda üreyen Gram negatif bakteriler servislerde üreyenlerden anlamlı derecede yüksek bulunmuştur (P
{"title":"Yoğun Bakım Üniteleri ve Yataklı Servislerde Yatan Hastaların Kültürlerinden Sık İzole Edilen Gram Negatif Bakteriler ve Antibiyotik Dirençlerinin Retrospektif Olarak Değerlendirilmesi","authors":"Zerife Orhan, Arzu Kayış, Burak Küçük, Murat Aral, Mehmet Kadir Yanilmaz","doi":"10.31832/smj.1142764","DOIUrl":"https://doi.org/10.31832/smj.1142764","url":null,"abstract":"Amaç: Bu çalışmada, 2020 yılı içerisinde hastanemizin yoğun bakım üniteleri ve yataklı servislerinden mikrobiyoloji laboratuvarına gönderilen çeşitli kültür örneklerinden izole edilen gram negatif bakteriler ve antibiyotik dirençlerinin retrospektif olarak değerlendirilmesi amaçlanmıştır. \u0000Metod: Ocak 2020-Aralık 2020 tarihleri arasında yoğun bakım üniteleri ve yataklı servislerden mikrobiyoloji laboratuvarına gönderilen çeşitli hasta örneklerinden sık izole edilen Gram negatif bakteriler çalışmaya dahil edilmiştir. Bakteri tanımlanması ve antibiyotik duyarlılık testleri konvansiyonel yöntemler ve otomatize sistemler kullanılarak yapılmıştır \u0000Bulgular: Bir yıllık süreçte yoğun bakım ünitelerindeki hastalardan sırasıyla %49.7’u endotrakeal aspirat kültürlerinden izole edilen 761 Acinetobacter baumanii, %51.7’si idrar kültüründen izole edilen 478 E. coli, %31.2’si endotrakeal aspirat kültürlerinden izole edilen 417 Klebsiella pneumoniae, %51.5’i endotrakeal aspirat kültürlerinden izole edilen Pseudomonas aeruginosa üremesi olmuştur. Yataklı servislerde ise %47.2’si idrar kültüründen izole edilen 316 Escherichia coli, %43.4’ü idrar kültürlerinden elde edilen 136 Klebsiella pneumoniae, %57.7’si yara kültürlerinden izole edilen 78 Pseudomonas aeruginosa, %60.3’ü yara kültürlerinden izole edilen 68 Acinetobacter baumanii üremesi olmuştur. Yoğun bakımlarda üreyen Gram negatif bakteriler servislerde üreyenlerden anlamlı derecede yüksek bulunmuştur (P","PeriodicalId":21405,"journal":{"name":"Sakarya Medical Journal","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87301890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ali Altan Ertan Boz, Mahmut Atum, E. Çelik, Gürsoy Alagöz
Amaç: Kapsül yetmezliğinde, katlanabilir arka kamara (AK) göz içi lenslerin irise sütürlü (İSGİL) implantasyonunun avantajları, dezavantajları, cerrahi tekniği ve postoperatif komplikasyonlar araştırıldı. Gereç ve Yöntemler: Kapsül ve zonül yetmezliği nedeni ile kapsül içi GİL implantasyonu yapılamayan, bu nedenle katlanabilir AK GİL’i irise sütüre ederek implante ettiğimiz 30 hastanın 30 gözü retrospektif olarak incelendi. Hastalar 2,8 mm’lik kesiden primer İSGİL implantasyonu (Grup 1), 6 mm’lik kesiden primer İSGİL implantasyonu (Grup 2), sekonder İSGİL implantasyonu (Grup 3) ve GİL stabilizasyonu (Grup 4) olmak üzere 4 gruba ayrıldı. Olguların tümünde preoperatif ve postoperatif en iyi düzeltilmiş görme keskinliği (EDGK), göz içi basıncı (GİB), merkezi korneal kalınlık (MKK) ve postoperatif GİL-endotel arası mesafe ölçümleri yapıldı. Postoperatif komplikasyonlar kaydedildi. Bulgular: Gruplarda EDGK preoperatif 0,58±0,20 /2,44±0,89 /0,53±0,26 /0,90±0,73 LogMAR iken postoperatif 0,33±0,57 /0,80±0,84 /0,50±0,62 /0,95±1,37 LogMAR seviyesinde idi. Postoperatif GİL-Endotel arası mesafe 3,11±0,28 /2,77±0,32 /3,09±0,37 /3,09±0,37 mm idi. Postoperatif dönemde, Grup 1’de 2 hastada kistoid maküler ödem (KMÖ), 1 hastada üveit, 1 hastada GİL desantralizasyonu; Grup 2’de 1 hastada KMÖ, 3 hastada GİL desantralizasyonu; Grup 3’te 2 hastada üveit ve KMÖ, 1 hastada retina dekolmanı (RD), 3 hastada GİL desantralizasyonu; Grup 4’te 1 hastada KMÖ, 1 hastada RD saptandı. Sonuç: Kapsül yetmezliğinde, GİL implantasyon yöntemi seçiminde hastanın klinik özellikleri, mevcut ekipmanların durumu ve cerrahın tecrübesi önemlidir. Her GİL implantasyon yönteminin, kendine has avantaj ve dezavantajları mevcuttur. Uyguladığımız GİL implantasyon yönteminin kapsül yetmezlikli hastalarda nispeten kolay uygulanması, özellikli GİL gereksinimi olmaması gibi yönleriyle, GİL implantasyon yöntemlerine alternatif olacağını düşünmekteyiz.
{"title":"Kapsül ve/veya Zonül Yetmezlikli Olguların Cerrahi Tedavisinde Tek Parça Katlanabilir Arka Kamara Göz İçi Lenslerin İrise Sütürlü Olarak Kullanılması","authors":"Ali Altan Ertan Boz, Mahmut Atum, E. Çelik, Gürsoy Alagöz","doi":"10.31832/smj.1163160","DOIUrl":"https://doi.org/10.31832/smj.1163160","url":null,"abstract":"Amaç: Kapsül yetmezliğinde, katlanabilir arka kamara (AK) göz içi lenslerin irise sütürlü (İSGİL) implantasyonunun avantajları, dezavantajları, cerrahi tekniği ve postoperatif komplikasyonlar araştırıldı. \u0000Gereç ve Yöntemler: Kapsül ve zonül yetmezliği nedeni ile kapsül içi GİL implantasyonu yapılamayan, bu nedenle katlanabilir AK GİL’i irise sütüre ederek implante ettiğimiz 30 hastanın 30 gözü retrospektif olarak incelendi. Hastalar 2,8 mm’lik kesiden primer İSGİL implantasyonu (Grup 1), 6 mm’lik kesiden primer İSGİL implantasyonu (Grup 2), sekonder İSGİL implantasyonu (Grup 3) ve GİL stabilizasyonu (Grup 4) olmak üzere 4 gruba ayrıldı. Olguların tümünde preoperatif ve postoperatif en iyi düzeltilmiş görme keskinliği (EDGK), göz içi basıncı (GİB), merkezi korneal kalınlık (MKK) ve postoperatif GİL-endotel arası mesafe ölçümleri yapıldı. Postoperatif komplikasyonlar kaydedildi. \u0000Bulgular: Gruplarda EDGK preoperatif 0,58±0,20 /2,44±0,89 /0,53±0,26 /0,90±0,73 LogMAR iken postoperatif 0,33±0,57 /0,80±0,84 /0,50±0,62 /0,95±1,37 LogMAR seviyesinde idi. Postoperatif GİL-Endotel arası mesafe 3,11±0,28 /2,77±0,32 /3,09±0,37 /3,09±0,37 mm idi. Postoperatif dönemde, Grup 1’de 2 hastada kistoid maküler ödem (KMÖ), 1 hastada üveit, 1 hastada GİL desantralizasyonu; Grup 2’de 1 hastada KMÖ, 3 hastada GİL desantralizasyonu; Grup 3’te 2 hastada üveit ve KMÖ, 1 hastada retina dekolmanı (RD), 3 hastada GİL desantralizasyonu; Grup 4’te 1 hastada KMÖ, 1 hastada RD saptandı. \u0000Sonuç: Kapsül yetmezliğinde, GİL implantasyon yöntemi seçiminde hastanın klinik özellikleri, mevcut ekipmanların durumu ve cerrahın tecrübesi önemlidir. Her GİL implantasyon yönteminin, kendine has avantaj ve dezavantajları mevcuttur. Uyguladığımız GİL implantasyon yönteminin kapsül yetmezlikli hastalarda nispeten kolay uygulanması, özellikli GİL gereksinimi olmaması gibi yönleriyle, GİL implantasyon yöntemlerine alternatif olacağını düşünmekteyiz.","PeriodicalId":21405,"journal":{"name":"Sakarya Medical Journal","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72995629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: One of the well-known prolonged effects of coronavirus disease 2019 (COVID-19) is the gradual loss of pulmonary functions, known as ‘long COVID’. Due to the importance of this deleterious condition, several studies have been conducted to investigate predictors of long COVID throughout hospital admission and after hospital discharge. Recently introduced, the atherogenic index of plasma (AIP) has a better predictive value for the prediction of adverse events in COVID-19 patients compared to other biomarkers. This study aimed to explore the role of AIP in the prediction of long COVID among COVID-19 survivors. Material and Methods: We evaluated 52 eligible patients with a diagnosis of long COVID and 80 healthy control subjects with a prior history of COVID-19. To confirm long COVID diagnosis, all subjects underwent a standardized questionnaire which recount the presence or absence of COVID-19-related complaints. All participants’ past medical records and clinical, and demographic characteristics were scanned and underwent comprehensive physical examination and echocardiographic assessment Results: According to our study, body surface area, Troponin T, NT-pro-BNP, and AIP were the independent predictors of long COVID. AIP was the best predictor of long COVID among the aforementioned parameters (p=0.005). To determine the AIP cut-off value for predicting long COVID, the receiver operating characteristic (ROC) curve was drawn and the best cut-off value was determined as 0.113 by using the Youden index, (AUC:0.658, 95% CI:0.556-0.760, P=0.002). Conclusion: Our data indicate that AIP is an independent predictor of long COVID.
{"title":"The role of atherogenic index of plasma in the diagnosis long COVID","authors":"M. Duran, Ercan Kurtipek, M. B. Özen","doi":"10.31832/smj.1175430","DOIUrl":"https://doi.org/10.31832/smj.1175430","url":null,"abstract":"Objective: One of the well-known prolonged effects of coronavirus disease 2019 (COVID-19) is the gradual loss of pulmonary functions, known as ‘long COVID’. Due to the importance of this deleterious condition, several studies have been conducted to investigate predictors of long COVID throughout hospital admission and after hospital discharge. Recently introduced, the atherogenic index of plasma (AIP) has a better predictive value for the prediction of adverse events in COVID-19 patients compared to other biomarkers. This study aimed to explore the role of AIP in the prediction of long COVID among COVID-19 survivors. \u0000Material and Methods: We evaluated 52 eligible patients with a diagnosis of long COVID and 80 healthy control subjects with a prior history of COVID-19. To confirm long COVID diagnosis, all subjects underwent a standardized questionnaire which recount the presence or absence of COVID-19-related complaints. All participants’ past medical records and clinical, and demographic characteristics were scanned and underwent comprehensive physical examination and echocardiographic assessment \u0000Results: According to our study, body surface area, Troponin T, NT-pro-BNP, and AIP were the independent predictors of long COVID. AIP was the best predictor of long COVID among the aforementioned parameters (p=0.005). To determine the AIP cut-off value for predicting long COVID, the receiver operating characteristic (ROC) curve was drawn and the best cut-off value was determined as 0.113 by using the Youden index, (AUC:0.658, 95% CI:0.556-0.760, P=0.002). \u0000Conclusion: Our data indicate that AIP is an independent predictor of long COVID.","PeriodicalId":21405,"journal":{"name":"Sakarya Medical Journal","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85497217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Recayi Capoglu, Zülfü Bayhan, Emre Gönüllü, Mertcan Akçay, Ahmet Tarık Harmantepe, Furkan Kucuk, H. Demi̇r
Amaç : Günümüzde yapılan bazı tiroid biyopsi sonuçlarında takip mi yoksa tedavi mi konusu halen tartışmalıdır. Hangi özelliklere sahip Tiroid nodüllerinde ameliyat veya takip yapılmasında birden fazla biyopsi yapılmasının tedavideki yerini araştırmayı amaçladık Yöntem : Bir üçüncü basamak hastanede 2014-2022 yılları arasında Tiroidektomi yapılan olgular retrospektif incelendi. Preoperatif biyopsi ve postoperatif patoloji sonuçları bağımsız değişkenlerle karşılaştırıldı. Bulgular : Radyolojik TI-RADS sınıflaması yüksek, artmış nodül çapı olan ve ilaçla regüle olan grupta artmış malignite riski görüldü (p < 0.05). Önemi belirsiz atipi grubunda artmış TI-RADS postoperatif malign patolojiyle uyumlu bulundu. Sonuç : İlk biyopsi sonucu cerrahi açıdan şüpheli olgularda TI-RADS sınıflaması ve nodül çapı tedavi açısından yol gösterici olabilir.
{"title":"TİROİD NODÜLÜ TANISINDA İNCE İĞNE ASPİRASYON BİYOPSİSİ TEKRARI GEREKLİ MİDİR ?","authors":"Recayi Capoglu, Zülfü Bayhan, Emre Gönüllü, Mertcan Akçay, Ahmet Tarık Harmantepe, Furkan Kucuk, H. Demi̇r","doi":"10.31832/smj.1183637","DOIUrl":"https://doi.org/10.31832/smj.1183637","url":null,"abstract":"Amaç : Günümüzde yapılan bazı tiroid biyopsi sonuçlarında takip mi yoksa tedavi mi konusu halen tartışmalıdır. Hangi özelliklere sahip Tiroid nodüllerinde ameliyat veya takip yapılmasında birden fazla biyopsi yapılmasının tedavideki yerini araştırmayı amaçladık \u0000Yöntem : Bir üçüncü basamak hastanede 2014-2022 yılları arasında Tiroidektomi yapılan olgular retrospektif incelendi. Preoperatif biyopsi ve postoperatif patoloji sonuçları bağımsız değişkenlerle karşılaştırıldı. \u0000Bulgular : Radyolojik TI-RADS sınıflaması yüksek, artmış nodül çapı olan ve ilaçla regüle olan grupta artmış malignite riski görüldü (p < 0.05). Önemi belirsiz atipi grubunda artmış TI-RADS postoperatif malign patolojiyle uyumlu bulundu. \u0000Sonuç : İlk biyopsi sonucu cerrahi açıdan şüpheli olgularda TI-RADS sınıflaması ve nodül çapı tedavi açısından yol gösterici olabilir.","PeriodicalId":21405,"journal":{"name":"Sakarya Medical Journal","volume":"160 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76626645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amaç: Tıpta uzmanlık eğitimi, hizmet ve eğitimin birlikte yürüdüğü dinamik bir süreçtir. Bu çalışmadaki amacımız, XXXXX Üniversitesi Tıp Fakültesi Araştırma Hastanesi’nde uzmanlık eğitimi alan uzmanlık öğrencilerinin, eğitimin niteliği, sosyal destek algıları ve özerklik algıları bakımından değerlendirmektir. Gereç ve Yöntemler: Çalışmanın evrenini XXXX Üniversitesi Tıp Fakültesi Hastanesi’nde uzmanlık eğitimi alan tıpta uzmanlık öğrencileri oluşturmakta olup, çalışmaya katılmayı kabul eden uzmanlık öğrencilerinden bir örneklem oluşturulmuştur. Çalışmada veri toplama aracı olarak; uzmanlık öğrencilerinin sosyo-demografik özellikleri, beklenti ve çalışma ortamlarını değerlendirmek amacıyla hazırlanan bir anket formu ile “Mezuniyet Sonrası Hastane Eğitim Ortamı Ölçeği” (MESHEÖ) kullanılmıştır. Bulgular: Çalışmamıza katılmayı kabul eden ve anketleri tam olarak dolduran %58,2 (n=53)’si kadın %41,7(n=38)’si erkek 91 uzmanlık öğrencisinin verileri dahil edildi. Tüm öğrencilerin MESHEÖ toplam skor değerlendirmesine göre ortalaması 90,22±18,79 olup ‘’Olumlu ancak geliştirilmesi gereken eğitim ortamı’’ şeklinde değerlendirdikleri görülmüştür. Tüm uzmanlık öğrencilerinin %58,2(n=53)’si eğitimleri sırasında tuttukları nöbet sayısının uzmanlık alanları ile uygun olmadığını düşünmekte olup, nöbet sayısından memnun olmayan asistanların MESHEÖ puanları diğerlerinden anlamlı olarak düşük bulunmuştur (p
{"title":"Tıpta Uzmanlık Öğrencilerinin Eğitim Ortamı Algılarını Etkileyen Faktörlerin Değerlendirilmesi","authors":"Zerrin Gamsizkan, M. A. Sungur, Gülcan Uludağ","doi":"10.31832/smj.1023888","DOIUrl":"https://doi.org/10.31832/smj.1023888","url":null,"abstract":"Amaç: Tıpta uzmanlık eğitimi, hizmet ve eğitimin birlikte yürüdüğü dinamik bir süreçtir. Bu çalışmadaki amacımız, XXXXX Üniversitesi Tıp Fakültesi Araştırma Hastanesi’nde uzmanlık eğitimi alan uzmanlık öğrencilerinin, eğitimin niteliği, sosyal destek algıları ve özerklik algıları bakımından değerlendirmektir. \u0000Gereç ve Yöntemler: Çalışmanın evrenini XXXX Üniversitesi Tıp Fakültesi Hastanesi’nde uzmanlık eğitimi alan tıpta uzmanlık öğrencileri oluşturmakta olup, çalışmaya katılmayı kabul eden uzmanlık öğrencilerinden bir örneklem oluşturulmuştur. Çalışmada veri toplama aracı olarak; uzmanlık öğrencilerinin sosyo-demografik özellikleri, beklenti ve çalışma ortamlarını değerlendirmek amacıyla hazırlanan bir anket formu ile “Mezuniyet Sonrası Hastane Eğitim Ortamı Ölçeği” (MESHEÖ) kullanılmıştır. \u0000Bulgular: Çalışmamıza katılmayı kabul eden ve anketleri tam olarak dolduran %58,2 (n=53)’si kadın %41,7(n=38)’si erkek 91 uzmanlık öğrencisinin verileri dahil edildi. Tüm öğrencilerin MESHEÖ toplam skor değerlendirmesine göre ortalaması 90,22±18,79 olup ‘’Olumlu ancak geliştirilmesi gereken eğitim ortamı’’ şeklinde değerlendirdikleri görülmüştür. Tüm uzmanlık öğrencilerinin %58,2(n=53)’si eğitimleri sırasında tuttukları nöbet sayısının uzmanlık alanları ile uygun olmadığını düşünmekte olup, nöbet sayısından memnun olmayan asistanların MESHEÖ puanları diğerlerinden anlamlı olarak düşük bulunmuştur (p","PeriodicalId":21405,"journal":{"name":"Sakarya Medical Journal","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80266463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: In this study, it’s aimed to examine biological and psychosocial risk perceptions, and expectations of life after treatment of the healthcare personnel who were diagnosed as covid-19 positive while working at the pandemic hospital and resumed after their treatments. Materials and Methods: In line with the purpose of the study, a case study method was adopted in the qualitative research approach. Among the purposive sampling methods, maximum diversity sampling is used for the sample of the study that is 13 healthcare workers working in different units and levels who have worked in the pandemic period. As the data collection tool, semi-structured form was used, and the data obtained through interview questions were transcribed word-by-word and analyzed using the content analysis technique using the Maxqda program. Results : The most common theme during the pandemic is “worry” which is a subcode of “negative feelings” under the “psychological factors” theme and the second most common dimension is “family” code under the theme of “social factors”. Conclusion: Even though some of the employees were working at the pandemic hospital, the belief that the risk of coronavirus infection was low to them was the most striking subject in the research process. This situation has been examined from the perspective of unrealistic optimism theory. It is explained by the assumption that information processing errors are made about the risks of the work or the tendency to deny the risk to reduce anxiety. Although the studies carried out in both aspects provide temporary relief for individuals, we think that the increase in this situation may reduce the behavior of taking measures against risks in individuals.
{"title":"A Qualitative Research on Identifying the Exposure and Risk Perceptions of Healthcare Workers who are Diagnosed with COVID-19","authors":"E. Yılmaz, O. Karabay, R. Altunişik","doi":"10.31832/smj.1073703","DOIUrl":"https://doi.org/10.31832/smj.1073703","url":null,"abstract":"Objective: In this study, it’s aimed to examine biological and psychosocial risk perceptions, and expectations of life after treatment of the healthcare personnel who were diagnosed as covid-19 positive while working at the pandemic hospital and resumed after their treatments. \u0000Materials and Methods: In line with the purpose of the study, a case study method was adopted in the qualitative research approach. Among the purposive sampling methods, maximum diversity sampling is used for the sample of the study that is 13 healthcare workers working in different units and levels who have worked in the pandemic period. As the data collection tool, semi-structured form was used, and the data obtained through interview questions were transcribed word-by-word and analyzed using the content analysis technique using the Maxqda program. \u0000Results : The most common theme during the pandemic is “worry” which is a subcode of “negative feelings” under the “psychological factors” theme and the second most common dimension is “family” code under the theme of “social factors”. \u0000Conclusion: Even though some of the employees were working at the pandemic hospital, the belief that the risk of coronavirus infection was low to them was the most striking subject in the research process. This situation has been examined from the perspective of unrealistic optimism theory. It is explained by the assumption that information processing errors are made about the risks of the work or the tendency to deny the risk to reduce anxiety. Although the studies carried out in both aspects provide temporary relief for individuals, we think that the increase in this situation may reduce the behavior of taking measures against risks in individuals.","PeriodicalId":21405,"journal":{"name":"Sakarya Medical Journal","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90210611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tuğba Kevser Uysal, Muhammet Örnek, Özen ÖZENSOY GÜLER
Cancer development and progression are associated with oxidative stress. Oxidative stress can favor high concentrations of reactive oxygen species (ROS), and free radicals are associated with antioxidant metabolism. The human enzyme paraoxonase (PON) contributes to antioxidant metabolism and decreased antioxidant levels. This leads to a high-risk factor for coronary heart disease. This review focuses on specific changes that affect the DNA molecule, and signaling pathways, and regulate the various cancers through the attraction of PON, an enzyme for degrading lipid peroxides within the cell as well as lipoproteins in the bloodstream.
{"title":"Oksidatif stres paraoksonaz enzim ailesinin (PON) kanser üzerindeki etkisini arttırır mı? Pon ailesinin oksidatif stres ve kanser ilişkisinin incelenmesini amaçlayan bir derleme","authors":"Tuğba Kevser Uysal, Muhammet Örnek, Özen ÖZENSOY GÜLER","doi":"10.31832/smj.1199508","DOIUrl":"https://doi.org/10.31832/smj.1199508","url":null,"abstract":"Cancer development and progression are associated with oxidative stress. Oxidative stress can favor high concentrations of reactive oxygen species (ROS), and free radicals are associated with antioxidant metabolism. The human enzyme paraoxonase (PON) contributes to antioxidant metabolism and decreased antioxidant levels. This leads to a high-risk factor for coronary heart disease. This review focuses on specific changes that affect the DNA molecule, and signaling pathways, and regulate the various cancers through the attraction of PON, an enzyme for degrading lipid peroxides within the cell as well as lipoproteins in the bloodstream.","PeriodicalId":21405,"journal":{"name":"Sakarya Medical Journal","volume":"84 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78067452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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