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Development of a quantitative job exposure matrix for standing, walking, and forward bending among pregnant workers - The PRECISE JEM. 怀孕工人站立、行走和前屈的定量工作暴露矩阵的开发-精确的JEM。
IF 4.3 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-11-01 Epub Date: 2025-09-18 DOI: 10.5271/sjweh.4252
Hannah Nørtoft Frankel, Esben Meulengracht Flachs, Camilla Sandal Sejbaek, Jonathan Aavang Petersen, Jens Peter Bonde, Ingrid Sivesind Mehlum, Mette Korshøj, Susan Peters, Magnus Svartengren, Pasan Hettiarachchi, Peter J Johansson, Alex Burdorf, Luise Mølenberg Begtrup

Objectives: Occupational physical activity (OPA) during pregnancy has been linked to adverse pregnancy outcomes, but crude exposure assessment remains an issue in causal inference. We aimed to develop a quantitative trimester-specific job exposure matrix (JEM) for standing, walking, and forward bending among pregnant workers.

Methods: Accelerometer measurements from 403 female workers across 109 DISCO-08 job codes were obtained in Denmark between January 2023 and June 2024. Full workdays were measured during two weeks among pregnant workers and one week among non-pregnant workers. We used linear mixed-effects models to estimate exposure levels of occupational standing, walking, and forward bending for all 1171 DISCO-08 codes, including age, trimester, and expert ratings as fixed effects, and job codes and workers as random effects.

Results: The between-job variances relative to total variances were 56% for standing, 51% for walking, and 45% for forward bending. The fixed effect trimester reduced standing time by 0.38 hours during the 3rd trimester compared to non-pregnant participants, whereas no differences were observed for walking or forward bending. Based on the trimester-specific JEM for occupational standing time, bakers had the highest exposure (range from non-pregnant to 3rd trimester, 5.41-5.03 hours/workday). For walking and forward bending, the highest exposed jobs from the pregnancy-specific JEM were waiters (1.76 hours/workday) and livestock/dairy producers (1.24 hours/workday), respectively.

Conclusions: The JEM enhances independent objective exposure assessment in epidemiological studies of OPA and pregnancy outcomes and may advance guidelines and potentially prevent adverse pregnancy outcomes.

目的:怀孕期间的职业体力活动(OPA)与不良妊娠结局有关,但在因果推理中,粗略的暴露评估仍然是一个问题。我们的目的是开发一个定量的孕期特异性工作暴露矩阵(JEM),用于怀孕工人的站立、行走和前屈。方法:在2023年1月至2024年6月期间,获得了丹麦109个DISCO-08工作代码的403名女性工人的加速度计测量值。在怀孕的工人中测量了两周内的全工作日,在未怀孕的工人中测量了一周内的全工作日。我们使用线性混合效应模型来估计所有1171个DISCO-08编码的职业站立、行走和前屈的暴露水平,包括年龄、孕期和专家评级作为固定效应,以及工作编码和工人作为随机效应。结果:工作间方差相对于总方差为站立56%,行走51%,前屈45%。与未怀孕的参与者相比,固定效应孕期在妊娠晚期减少了0.38小时的站立时间,而在行走或前屈方面没有观察到差异。根据职业站立时间的孕期特异性JEM,面包师的暴露时间最高(从未怀孕到妊娠晚期,5.41-5.03小时/工作日)。对于行走和前屈,暴露于怀孕特异性JEM的最高工作分别是服务员(1.76小时/工作日)和牲畜/乳制品生产者(1.24小时/工作日)。结论:JEM在OPA和妊娠结局的流行病学研究中加强了独立客观的暴露评估,并可能推进指导和潜在地预防不良妊娠结局。
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引用次数: 0
Risk factors for voluntary early old-age retirement in middle-aged workers: A meta-analysis. 中年职工自愿提前退休的危险因素:meta分析。
IF 4.3 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-11-01 Epub Date: 2025-07-25 DOI: 10.5271/sjweh.4241
Rahman Shiri, Joonas Poutanen, Eija Haukka, Mikko Härmä, Jenni Ervasti

Objective: This meta-analysis aimed to identify sociodemographic, lifestyle, work-related and health risk factors for voluntary early old-age retirement among middle-aged workers.

Methods: Searches were conducted in PubMed, Web of Science, PsycInfo, and Scopus from their inception until February 2025. Observational longitudinal studies involving workers aged 40-64 years were included. Two reviewers evaluated the methodological quality of the studies. A random-effects meta-analysis was performed, and heterogeneity and publication bias were assessed.

Results: From 13 899 publications, 23 longitudinal studies (N=2 270 430 participants) were included. The following factors were associated with an increased risk of early old-age retirement: age [hazard ratio (HR) 1.35, 95% CI (confidence interval) 1.12-1.63 per year increase], overweight or obesity (HR 1.10, 95% CI 1.03-1.17), physically demanding work (HR 1.29, 95% CI 1.05-1.59), low job control (HR 1.14, 95% CI 1.11-1.17), low influence at work (HR 1.10, 95% CI 1.02-1.19), low organizational justice (HR 1.27, 95% CI 1.10-1.46), lack of skills and knowledge development (HR 2.16, 95% CI 1.63-2.85), suboptimal self-rated general health (HR 1.22, 95% CI 1.12-1.34), chronic physical conditions (HR 1.11, 95% CI 1.05-1.17), and depressive symptoms (HR 1.34, 95% CI 1.12-1.61). Conversely, a lower risk was found among individuals who were unmarried, separated, or widowed (HR 0.74, 95% CI 0.60-0.91).

Conclusions: This meta-analysis underscores the impact of overweight, physical and psychosocial work factors, lacking skills and knowledge development and health conditions on early old-age retirement risk among middle-aged workers. Targeted interventions to encourage healthy lifestyles, foster a supportive work environment, and promote mental health may help to reduce early old-age retirement risk.

目的:本荟萃分析旨在确定中年工人自愿提前退休的社会人口、生活方式、工作和健康风险因素。方法:检索PubMed、Web of Science、PsycInfo和Scopus,检索时间从网站创建到2025年2月。包括40-64岁工人的观察性纵向研究。两位审稿人评估了研究的方法学质量。进行随机效应荟萃分析,评估异质性和发表偏倚。结果:从13 899篇出版物中,纳入23项纵向研究(N=2 270 430名受试者)。以下因素与提前退休的风险增加有关:年龄[风险比(HR) 1.35, 95% CI(置信区间)1.12-1.63,每年增加],超重或肥胖(HR 1.10, 95% CI 1.03-1.17),体力要求高的工作(HR 1.29, 95% CI 1.05-1.59),低工作控制力(HR 1.14, 95% CI 1.11-1.17),低工作影响力(HR 1.10, 95% CI 1.02-1.19),低组织公正(HR 1.27, 95% CI 1.10-1.46),缺乏技能和知识发展(HR 2.16, 95% CI 1.63-2.85),次理想的自我评估一般健康(HR 1.22, 95% CI 1.12-1.34),慢性身体状况(HR 1.11, 95% CI 1.05-1.17)和抑郁症状(HR 1.34, 95% CI 1.12-1.61)。相反,在未婚、分居或丧偶的个体中发现的风险较低(HR 0.74, 95% CI 0.60-0.91)。结论:本荟萃分析强调了超重、身体和社会心理工作因素、缺乏技能和知识发展以及健康状况对中年工人早期老年退休风险的影响。鼓励健康的生活方式、营造支持性的工作环境和促进心理健康的有针对性的干预措施可能有助于减少老年提前退休的风险。
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引用次数: 0
Requirements for occupational exposure limits in psychosocial risk assessment: What we know, what we don't know and what we can learn from other disciplines. 社会心理风险评估中职业暴露限值的要求:我们知道什么,我们不知道什么,以及我们可以从其他学科中学到什么。
IF 4.3 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-11-01 Epub Date: 2025-09-04 DOI: 10.5271/sjweh.4247
Roman Pauli, Jessica Lang, Andreas Müller, Yacine Taibi, Thomas Kraus, Yannick Metzler

Objectives: This discussion paper aims to provide recommendations for the development of occupational exposure limits (OEL) for psychosocial hazards. By comparing the characteristics of non-psychosocial and psychosocial hazards at work as well as approaches to derive occupational limit values for both types of hazards, the paper summarizes conceptual requirements and methodological perspectives for OEL in psychosocial risk assessment.

Methods: An interdisciplinary working group comprised of academics, active practitioners in company occupational health management and members of national committees advising policymakers conducted regular face-to-face and online meetings between October 2022 and August 2024 to draft a narrative review and discussion of the current state of research on OEL for psychosocial hazards within the fields of psychology, sociology and medicine.

Results: The current field of research is in its early stages, indicated by individual efforts and a lack of joint decision-making. Existing approaches towards OEL focus on disease-level outcomes (eg, burnout, depression), which limits their effectiveness for primary prevention and identifying early warning signs of harm.

Conclusion: Based on the limited existing literature, we recommend (i) the use of outcome variables that enable detection of early stages of adverse effects aligned with the no-observed adverse effect level (NOAEL) and the lowest-observed-adverse effect level (LOAEL), (ii) standardization and harmonization of hitherto independent assessments of identical hazards, and (iii) policy-level actions to foster collaborative decision-making based on the full spectrum of scientific evidence.

目的:本讨论文件旨在为社会心理危害职业暴露限值的制定提供建议。通过比较(I)工作中非社会心理和社会心理危害的特征,以及(II)推导两种危害的职业限值的方法,本文总结了社会心理风险评估中职业暴露限值的概念要求和方法学观点。方法:在2022年10月至2024年8月期间,通过定期面对面和在线会议,在心理学、社会学和医学跨学科工作组内对研究现状进行叙述性回顾和讨论。结果:目前关于职业暴露极限对社会心理危害的研究领域还处于早期阶段,这表明个人的努力和缺乏共同决策。最初的方法采用类似疾病的结果(倦怠、抑郁),在初级预防和早期发现症状发作方面失败。结论:基于有限的现有文献,我们建议(1)使用结果变量来检测与NOAEL和LOAEL一致的早期不良影响;(2)标准化和统一迄今为止对相同危害的独立评估;(3)政策层面的行动,以促进基于全面科学证据的协作决策。
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引用次数: 0
The impact of telework allowance and utilization on physiological and perceived stress among Swedish white-collar workers. 远程办公津贴和利用对瑞典白领生理压力和感知压力的影响?
IF 4.3 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-09-01 Epub Date: 2025-05-28 DOI: 10.5271/sjweh.4234
Leticia Bergamin Januario, Marina Heiden, Svend Erik Mathiassen, Gunnar Bergström, David M Hallman

Objective: We aimed to assess the impact of telework conditions on stress levels among 294 Swedish white-collar workers.

Methods: Telework during the COVID-19 pandemic was evaluated in terms of the allowance to telework (ie, the degree to which the employee could decide whether to telework), and the utilization of that allowance, using self-reported questions with answers dichotomized into 'high' and 'low'. Perceived stress was measured using the Single Item Stress Question and physiological stress was measured using parameters of heart rate variability (HRV) continuously for three days [root mean square of successive differences (RMSSD) and standard deviation of the interbeat intervals of normal heart beats (SDNN)]. Multilevel linear mixed models examined the effects of telework allowance and utilization on perceived stress and HRV during work, leisure and sleep.

Results: High allowance was associated with higher HRV (lower stress), while a high utilization of telework was associated with higher perceived stress and lower HRV (more stress). After adjusting for age, sex, body mass index, and objectively measured physical activity, these associations became smaller and/or non-significant, with exception of high allowance still being positively associated with higher RMSSD.

Conclusions: Our findings indicate that allowing employees more autonomy in telework decisions (ie, a high allowance in this study) is associated with reduced physiological stress. These results can be used by organizations to improve telework conditions (how, where and how much), while being observant that white-collar workers do not utilize increased autonomy to work extensively and for long hours outside work. Further verification, preferably using prospective designs, is needed to confirm our results.

目的:我们旨在评估远程工作条件对294名瑞典白领压力水平的影响。方法:采用答案分为“高”和“低”的自我报告问题,对COVID-19大流行期间的远程工作进行评估,评估远程工作的津贴(即员工可以决定是否远程工作的程度)以及津贴的利用情况。知觉应激采用单项应激题测量,生理应激采用心率变异性参数(HRV)连续3天测量[连续差值均方根(RMSSD)和正常心跳间隔时间标准差(SDNN)]。多水平线性混合模型检验了远程办公允许和利用对工作、休闲和睡眠期间感知压力和心率变异的影响。结果:高容许率与高HRV(低压力)相关,而高远程办公利用率与高感知压力和低HRV(更多压力)相关。在调整了年龄、性别、体重指数和客观测量的身体活动后,这些关联变得更小和/或不显著,除了高摄入量仍然与较高的RMSSD呈正相关。结论:我们的研究结果表明,允许员工在远程工作决策中拥有更多的自主权(即本研究中的高自由度)与减少生理压力有关。这些结果可以被组织用来改善远程工作条件(如何,在哪里和多少),同时观察到白领工人没有利用增加的自主权来广泛和长时间地工作。需要进一步验证,最好使用前瞻性设计,以确认我们的结果。
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引用次数: 0
Productivity changes during the COVID-19 pandemic and its associated risk factors. 2019冠状病毒病大流行期间的生产力变化及其相关风险因素。
IF 4.3 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-09-01 Epub Date: 2025-06-18 DOI: 10.5271/sjweh.4237
Guilherme Monteiro Sanchez Dalla Riva, Sander K R van Zon, Patricia Ots, Gerard van den Berg, Sandra Brouwer, Raun van Ooijen

Objective: This study aimed to investigate productivity loss during the COVID-19 pandemic and identify risk factors by examining indicators of work productivity loss in a population-based cohort in The Netherlands.

Methods: Longitudinal data from the Lifelines COVID-19 cohort were used, enriched with registry data from Statistics Netherlands. Data of N=11 462 workers were collected from 2020-2022. Productivity loss was measured using four indicators: unemployment, sickness absence rate, loss of work hours, and loss of work quality. Generalized estimating equations were used to examine the association between socioeconomic, health-, and work-related characteristics and the four indicators.

Results: Unemployment remained low (<0.5%) throughout the pandemic. In contrast, prevalence of sickness absence, reduction of work hours and work quality peaked at 8.7%, 15%, and 4.7%, respectively. Critical work was associated with higher odds of sickness absence and quality loss, but lower odds of unemployment and loss of hours. Younger age and recent COVID-19 were associated with higher odds of sickness absence, loss of work hours and quality. Chronic health conditions were associated with higher odds of sickness absence and quality loss. Having children was associated with lower odds of unemployment and loss of hours.

Conclusion: Despite low unemployment rates, productivity loss was observed at other indicators: sickness absence, loss of hours and quality. In addition, productivity was lost unequally among groups. When preparing for future crises, attention should be paid to broader indicators of productivity loss among different groups. Findings may help for offering targeted interventions to minimize losses in productivity and protect higher risk groups of workers.

目的:本研究旨在调查2019冠状病毒病大流行期间的生产力损失,并通过检查荷兰以人群为基础的队列中的工作生产力损失指标来确定风险因素。方法:采用来自生命线COVID-19队列的纵向数据,并辅以荷兰统计局的注册表数据。从2020-2022年收集了N=11 462名工人的数据。生产率损失用四个指标来衡量:失业率、病假缺勤率、工作时间损失和工作质量损失。使用广义估计方程来检验社会经济、健康和工作相关特征与这四个指标之间的关系。结果:失业率保持在较低水平(结论:尽管失业率较低,但在病假、工时损失和质量等其他指标上观察到生产率下降。此外,各群体之间的生产力损失也是不平等的。在为未来的危机做准备时,应注意不同群体之间生产力损失的更广泛指标。研究结果可能有助于提供有针对性的干预措施,以尽量减少生产力损失,并保护高危工人群体。
{"title":"Productivity changes during the COVID-19 pandemic and its associated risk factors.","authors":"Guilherme Monteiro Sanchez Dalla Riva, Sander K R van Zon, Patricia Ots, Gerard van den Berg, Sandra Brouwer, Raun van Ooijen","doi":"10.5271/sjweh.4237","DOIUrl":"10.5271/sjweh.4237","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate productivity loss during the COVID-19 pandemic and identify risk factors by examining indicators of work productivity loss in a population-based cohort in The Netherlands.</p><p><strong>Methods: </strong>Longitudinal data from the Lifelines COVID-19 cohort were used, enriched with registry data from Statistics Netherlands. Data of N=11 462 workers were collected from 2020-2022. Productivity loss was measured using four indicators: unemployment, sickness absence rate, loss of work hours, and loss of work quality. Generalized estimating equations were used to examine the association between socioeconomic, health-, and work-related characteristics and the four indicators.</p><p><strong>Results: </strong>Unemployment remained low (<0.5%) throughout the pandemic. In contrast, prevalence of sickness absence, reduction of work hours and work quality peaked at 8.7%, 15%, and 4.7%, respectively. Critical work was associated with higher odds of sickness absence and quality loss, but lower odds of unemployment and loss of hours. Younger age and recent COVID-19 were associated with higher odds of sickness absence, loss of work hours and quality. Chronic health conditions were associated with higher odds of sickness absence and quality loss. Having children was associated with lower odds of unemployment and loss of hours.</p><p><strong>Conclusion: </strong>Despite low unemployment rates, productivity loss was observed at other indicators: sickness absence, loss of hours and quality. In addition, productivity was lost unequally among groups. When preparing for future crises, attention should be paid to broader indicators of productivity loss among different groups. Findings may help for offering targeted interventions to minimize losses in productivity and protect higher risk groups of workers.</p>","PeriodicalId":21528,"journal":{"name":"Scandinavian journal of work, environment & health","volume":" ","pages":"394-403"},"PeriodicalIF":4.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12414509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gender differences in work-family conflict and mental health of Swedish workers by childcare responsibilities: findings from the SLOSH cohort study. 瑞典工人工作家庭冲突和心理健康的性别差异与儿童保育责任:来自SLOSH队列研究的结果。
IF 4.3 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-09-01 Epub Date: 2025-04-21 DOI: 10.5271/sjweh.4231
Yamna Taouk, Tania King, Constanze Leineweber, Brendan Churchill, Leah Ruppanner, Linda Magnusson Hanson

Objectives: In Sweden, the number of working-aged women in employment is now almost equal to that of men. While this has many benefits, it presents challenges in organizing work and non-work responsibilities around children, which may impact employees` mental health.

Methods: Based on the Swedish Longitudinal Occupational Survey of Health (SLOSH) cohort study, we prospectively examined gender differences for the effects of work-family conflict and caring for children on mental health among Swedish workers. Mental health status was assessed using a brief (Hopkins) symptom checklist depression scale. We used information from three waves of data over five years (2014-2018) for 5846 women and 4219 men aged 20-64 at baseline. Linear fixed-effects analyses were performed examining within-person changes in work interfering with family (WFC) and family interfering with work (FWC) and associated changes in depressive symptoms by childcare intensity (0, 1-10, >10 hours/week) and sex.

Results: Changes in mean scores for WFC and FWC were associated with changes in depressive symptoms for men [no childcaring: WFC 1.31 (95% confidence interval (CI) 1.13-1.49), FWC 0.70 (95% CI 0.43-0.96); childcaring >10 hours/week: WFC 1.39 (95% CI 0.53-2.25), FWC 1.24 (95% CI 0.27-2.21)] and women [no childcaring: WFC 1.57 (95% CI 1.41-1.73), FWC 1.04 (95% CI 0.79-1.30); childcaring >10 hours/week: WFC 2.04 (95% CI 1.36-2.73), FWC 1.57 (95% CI 0.82-2.32)].

Conclusion: Higher levels of WFC and FWC are associated with increased depressive symptoms in both men and women. The impact is greater for those with greater childcaring responsibilities intensity.

目标:在瑞典,工作年龄妇女的就业人数现在几乎与男子相等。虽然这有很多好处,但它也给围绕孩子组织工作和非工作责任带来了挑战,这可能会影响员工的心理健康。方法:基于瑞典纵向职业健康调查(SLOSH)队列研究,我们前瞻性地考察了工作-家庭冲突和照顾儿童对瑞典工人心理健康影响的性别差异。心理健康状况评估使用简短的(霍普金斯)抑郁症状检查表。我们使用了五年内(2014-2018年)三波数据的信息,其中5846名女性和4219名男性的基线年龄为20-64岁。采用线性固定效应分析,考察工作干扰家庭(WFC)和家庭干扰工作(FWC)的个人内部变化,以及受托儿强度(0,1 -10,bbb10小时/周)和性别影响的抑郁症状的相关变化。结果:WFC和FWC平均得分的变化与男性抑郁症状的变化相关[无育儿:WFC 1.31(95%可信区间(CI) 1.13-1.49), FWC 0.70 (95% CI 0.43-0.96);每周照顾孩子10小时:WFC 1.39 (95% CI 0.53-2.25), FWC 1.24 (95% CI 0.27-2.21)]和女性[不照顾孩子:WFC 1.57 (95% CI 1.41-1.73), FWC 1.04 (95% CI 0.79-1.30);每周照顾孩子10小时:WFC为2.04 (95% CI 1.36-2.73), FWC为1.57 (95% CI 0.82-2.32)。结论:高水平的WFC和FWC与男性和女性抑郁症状的增加有关。照顾孩子的责任强度越大,这种影响就越大。
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引用次数: 0
Detailed mapping of mesothelioma cases in Denmark to identify areas with elevated risk: a nationwide population-based study. 丹麦间皮瘤病例的详细制图,以确定高风险地区:一项全国性的基于人群的研究。
IF 4.3 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-09-01 Epub Date: 2025-05-06 DOI: 10.5271/sjweh.4229
Heidi Søgaard Christensen, Rikke Hedegaard Jensen, Lars Hernández Nielsen, Lise Dueholm Bertelsen, Christian Teglgaard, Jakob Hjort Bønløkke, Marianne Tang Severinsen, Martin Bøgsted

Objectives: Previous studies mapping pleural mesothelioma in Denmark have found that the risk varies between Danish regions. However, evaluating disease risk for such relatively large geographical units ignores any heterogeneity within the unit and can thus diminish more local spikes in risk, missing smaller areas of excess risk. In this study, we examined the distribution of pleural mesothelioma in Denmark on an unprecedented detailed scale, mapping cases to each of the Danish parishes.

Methods: We identified individuals diagnosed with pleural mesothelioma between 1990 and 2021 in the Danish Cancer Registry. Considering age- and sex-standardized incidence rate ratios (IRR), we used a conditional autoregressive random effects model to smooth IRR across parishes. Parishes with a smoothed parish-to-national IRR >1.25 or >2.0 with a posterior probability of >95% were flagged as parishes with an excess risk of pleural mesothelioma.

Results: We identified 3105 incident cases of pleural mesothelioma in the study period. A total of 74 and 14 parishes were flagged with IRR significantly above 1.25 and 2.0, respectively. These parishes had posterior mean smoothed IRR of 1.82-4.13.

Conclusions: We provided a detailed mapping of pleural mesothelioma cases in Denmark and found five distinct areas, each covering several parishes, with a significantly elevated risk. All these areas were in the proximity of previous asbestos-using industries.

目的:以前的研究在丹麦绘制胸膜间皮瘤已经发现丹麦地区之间的风险有所不同。然而,评估这种相对较大的地理单位的疾病风险忽略了单位内的任何异质性,因此可以减少更多的局部风险高峰,而忽略了较小的过度风险区域。在这项研究中,我们以前所未有的详细规模检查了丹麦胸膜间皮瘤的分布,将病例映射到丹麦的每个教区。方法:我们在丹麦癌症登记处找到1990年至2021年间诊断为胸膜间皮瘤的个体。考虑到年龄和性别标准化发病率比(IRR),我们使用了一个条件自回归随机效应模型来平滑各教区的IRR。教区与全国IRR平滑值为>1.25或>2.0,后检概率为>95%的教区被标记为胸膜间皮瘤风险过高的教区。结果:我们在研究期间发现了3105例胸膜间皮瘤病例。共有74个教区和14个教区的IRR分别显著高于1.25和2.0。这些教区的后验平均平滑IRR为1.82-4.13。结论:我们提供了丹麦胸膜间皮瘤病例的详细地图,并发现了五个不同的区域,每个区域覆盖几个教区,风险显著升高。所有这些地区都靠近以前使用石棉的工业。
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引用次数: 0
Capturing occupational risk of airborne disease: An international job-exposure matrix based on five exposure factors. 捕捉空气传播疾病的职业风险:基于五个暴露因素的国际工作暴露矩阵。
IF 4.3 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-09-01 Epub Date: 2025-05-22 DOI: 10.5271/sjweh.4235
Karen M Oude Hengel, Susan Peters, Zara A Stokholm, Alex Burdorf, Anjoeka Pronk, Henrik A Kolstad, Martie van Tongeren, Ioannis Basinas, Vivi Schlünssen

Objective: This study aimed to construct a job-exposure matrix (JEM) for the risk of being infected by infectious agents through airborne or droplet transmission in an occupational setting, which might lead to a respiratory disease.

Methods: An established COVID-19-JEM formed the basis for the development of the general airborne infectious agents JEM. Nine researchers in occupational epidemiology from three European countries (Denmark, The Netherlands and the United Kingdom) discussed and agreed on which factors from the COVID-19-JEM were relevant and whether new factors or adjustments of risk levels were needed. Adjustments to the COVID-19 JEM were made in a structured iterative. based on an expert assessment, a JEM on solar ultraviolet radiation (UVR) exposure including information on hours per day working inside, and national data on hours per week on site. Finally, a risk score was assigned to all factors for each job title within the International Standard Classification of Occupations system 2008 (ISCO-08).

Results: This airborne infectious agents JEM contains five factors: (i) hours spent per week on site, (ii) hours spent per day working inside, (iii) number and (iv) nature of contacts, and (v) being in close physical contact to others. Per occupation, a risk score ranging from 1 (low risk) to 3 (high risk) was provided for all five factors separately.

Conclusion: This newly developed infectious agents JEM assesses the risk at population level using five factors. Following validation, this JEM could serve as a valuable tool in future studies investigating the role of work in the occurrence of a respiratory disease.

目的:构建工作暴露矩阵(job-exposure matrix, JEM),分析职业环境中通过空气或飞沫传播感染传染病的风险。方法:已建立的COVID-19-JEM为一般空气传播媒介JEM的发展奠定了基础。来自三个欧洲国家(丹麦、荷兰和英国)的九名职业流行病学研究人员讨论并就COVID-19-JEM的哪些因素相关以及是否需要新的因素或调整风险水平达成一致。在结构化迭代中对COVID-19 JEM进行了调整。在专家评估的基础上,对太阳紫外线辐射(UVR)暴露进行了JEM,包括每天在室内工作的小时数信息,以及每周在现场工作的小时数的国家数据。最后,在2008年国际职业标准分类系统(ISCO-08)中,对每个职位的所有因素进行风险评分。结果:空气传播媒介JEM包含5个因素:(i)每周在现场工作的时间,(ii)每天在室内工作的时间,(iii)接触者的数量和(iv)接触者的性质,以及(v)与他人密切身体接触。对于每个职业,分别为所有五个因素提供了从1(低风险)到3(高风险)的风险评分。结论:新发现的传染性病原体JEM可通过5个因素对人群的危险性进行评估。在验证之后,该JEM可以作为未来研究工作在呼吸系统疾病发生中的作用的有价值的工具。
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引用次数: 0
Immune modulating effects of continuous bioaerosol and terpene exposure over three years among sawmill workers in Norway. 挪威锯木厂工人连续三年接触生物气溶胶和萜烯的免疫调节作用。
IF 4.3 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-09-01 Epub Date: 2025-07-08 DOI: 10.5271/sjweh.4240
Anne Straumfors, Fred Haugen, Øivind Skare, Wijnand Eduard, Paul K Henneberger, Jeroen Douwes, Bente Ulvestad, Karl-Christian Nordby

Objectives: Exposure to wood dust, resin acids, microbial and volatile components among sawmill workers may impair respiratory health, with inflammation indicated as a key mechanism. Previous, mostly cross-sectional studies have shown mixed results, and a conclusive association between wood dust exposure and chronic respiratory inflammation has therefore not yet been established. This study assessed associations between exposure to bioaerosols and volatile terpenes and serum inflammatory marker levels over three years.

Methods: Serum biomarkers and blood cell counts were analyzed based on 702 observations from 450 exposed sawmill workers and 102 observations from 65 unexposed sawmill workers in Norway at baseline and after three years. Job-exposure-matrices, based on measurements among the same cohort, were used to assess exposures for wood dust, endotoxins, resin acid, monoterpenes, fungal spores, and fungal fragments. Changes in exposures, biomarkers and cell counts over the study period, as well as group differences and potential cause-and-effect associations were assessed using linear mixed regression.

Results: Exposures were relatively low and below occupational limits, although variances were relatively high (GSDtot 2.1-8.3), largely driven by differences between workers (GSDbw 1.9-7.8). Serum CC-16 and mCRP were slightly higher after three years, whereas IL-1β, TNF-α and IL-10 levels were significantly lower among exposed compared with unexposed workers. Exposures positively associated with increases in biomarker levels included endotoxin with mCRP, monoterpenes with IL-10, and fungal spores with TNF-α and IL-8. Exposed workers had higher counts of total leucocytes, neutrophils, lymphocytes and basophils after three years. Several of the increased leucocyte counts were associated with concurrent increase in mCRP and IL-6 concentrations, predominantly in the exposed group. Conversely, increased CC-16 levels were associated with lower leucocyte and neutrophil counts, mainly in the unexposed group.

Conclusion: Continuous exposure to wood dust and related components for three years appears to induce a chronic low-grade inflammatory response among sawmill workers with a shift in cytokine profiles towards a less regulated, potentially more muted immune state.

目的:在锯木厂工人中,暴露于木屑、树脂酸、微生物和挥发性成分可能会损害呼吸道健康,炎症被认为是一个关键机制。以前的研究大多是横断面研究,结果好坏参半,因此木屑暴露与慢性呼吸道炎症之间的结论性联系尚未建立。这项研究评估了三年内暴露于生物气溶胶和挥发性萜烯与血清炎症标志物水平之间的关系。方法:在基线和三年后,分析了挪威450名暴露的锯木厂工人的702项观察结果和65名未暴露的锯木厂工人的102项观察结果的血清生物标志物和血细胞计数。基于同一队列测量的工作暴露矩阵用于评估木屑、内毒素、树脂酸、单萜烯、真菌孢子和真菌碎片的暴露。使用线性混合回归评估了研究期间暴露、生物标志物和细胞计数的变化,以及组间差异和潜在的因果关系。结果:暴露相对较低且低于职业限值,尽管差异相对较高(gsddbw 2.1-8.3),主要是由工人之间的差异(gsddbw 1.9-7.8)驱动的。三年后,暴露工人的血清CC-16和mCRP水平略高,而IL-1β、TNF-α和IL-10水平明显低于未暴露工人。与生物标志物水平升高正相关的暴露包括内毒素(含mCRP)、单萜烯(含IL-10)和真菌孢子(含TNF-α和IL-8)。三年后,暴露的工人白细胞、中性粒细胞、淋巴细胞和嗜碱性粒细胞总数较高。一些白细胞计数的增加与mCRP和IL-6浓度的同时增加有关,主要发生在暴露组。相反,增加的CC-16水平与较低的白细胞和中性粒细胞计数有关,主要是在未暴露组。结论:连续三年暴露于木屑和相关成分中,似乎会在锯木厂工人中诱发慢性低度炎症反应,并使细胞因子谱向调节较少、可能更弱的免疫状态转变。
{"title":"Immune modulating effects of continuous bioaerosol and terpene exposure over three years among sawmill workers in Norway.","authors":"Anne Straumfors, Fred Haugen, Øivind Skare, Wijnand Eduard, Paul K Henneberger, Jeroen Douwes, Bente Ulvestad, Karl-Christian Nordby","doi":"10.5271/sjweh.4240","DOIUrl":"10.5271/sjweh.4240","url":null,"abstract":"<p><strong>Objectives: </strong>Exposure to wood dust, resin acids, microbial and volatile components among sawmill workers may impair respiratory health, with inflammation indicated as a key mechanism. Previous, mostly cross-sectional studies have shown mixed results, and a conclusive association between wood dust exposure and chronic respiratory inflammation has therefore not yet been established. This study assessed associations between exposure to bioaerosols and volatile terpenes and serum inflammatory marker levels over three years.</p><p><strong>Methods: </strong>Serum biomarkers and blood cell counts were analyzed based on 702 observations from 450 exposed sawmill workers and 102 observations from 65 unexposed sawmill workers in Norway at baseline and after three years. Job-exposure-matrices, based on measurements among the same cohort, were used to assess exposures for wood dust, endotoxins, resin acid, monoterpenes, fungal spores, and fungal fragments. Changes in exposures, biomarkers and cell counts over the study period, as well as group differences and potential cause-and-effect associations were assessed using linear mixed regression.</p><p><strong>Results: </strong>Exposures were relatively low and below occupational limits, although variances were relatively high (GSD<sub>tot</sub> 2.1-8.3), largely driven by differences between workers (GSD<sub>bw</sub> 1.9-7.8). Serum CC-16 and mCRP were slightly higher after three years, whereas IL-1β, TNF-α and IL-10 levels were significantly lower among exposed compared with unexposed workers. Exposures positively associated with increases in biomarker levels included endotoxin with mCRP, monoterpenes with IL-10, and fungal spores with TNF-α and IL-8. Exposed workers had higher counts of total leucocytes, neutrophils, lymphocytes and basophils after three years. Several of the increased leucocyte counts were associated with concurrent increase in mCRP and IL-6 concentrations, predominantly in the exposed group. Conversely, increased CC-16 levels were associated with lower leucocyte and neutrophil counts, mainly in the unexposed group.</p><p><strong>Conclusion: </strong>Continuous exposure to wood dust and related components for three years appears to induce a chronic low-grade inflammatory response among sawmill workers with a shift in cytokine profiles towards a less regulated, potentially more muted immune state.</p>","PeriodicalId":21528,"journal":{"name":"Scandinavian journal of work, environment & health","volume":" ","pages":"433-443"},"PeriodicalIF":4.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12415592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144592137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Can pre-existing medical conditions explain occupational differences in COVID-19 disease severity? An analysis of 3.17 million people insured in Germany. 先前存在的医疗状况能否解释COVID-19疾病严重程度的职业差异?对德国317万参保人员的分析。
IF 4.3 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-09-01 Epub Date: 2025-08-09 DOI: 10.5271/sjweh.4242
Robert Guţu, Valerie Schaps, Benjamin Wachtler, Florian Beese, Jens Hoebel, Marco Alibone, Morten Wahrendorf

Objective: Occupational differences in COVID-19 are well documented, but the empirical evidence on potential reasons for these differences remains limited. Possible reasons include pre-existing health conditions. This study investigated occupational differences in COVID-19 disease severity and whether they can be attributed to pre-existing health conditions.

Methods: Our study used German health insurance data covering 3.17 million insured individuals (age 18-67 years), with details on COVID-19-related hospitalization and mortality in 2020 and 2021, information on occupation (regrouped into four classifications) and pre-existing health conditions (divided into seven disease groups). In addition to descriptive statistics, we estimated multivariable Cox regression models with varying sets of adjustments.

Results: We found clear occupational differences in COVID-19 hospitalization and mortality, with the highest risks for the production sector (especially manufacturing), commercial services (especially cleaning) and for low-skilled occupations. These findings persisted after adjusting for age, sex, and region, and also after mutual adjustment for other occupational classifications. We also found some evidence that the association between occupation and disease severity was partly explained by pre-existing conditions, especially in the case of low skill levels.

Conclusions: Our findings provide support for occupational differences in COVID-19, where the occupational classifications under study were independently related to risk differences (eg, skill-level and job sector). Furthermore, we provide empirical evidence that differences by occupational skill levels are partly due to pre-existing conditions. This finding suggests that occupational inequalities in health increased during the pandemic, with those with poorer health who worked in disadvantaged occupations also being more likely to experience severe COVID-19 outcomes.

目的:COVID-19职业差异有据可查,但关于这些差异潜在原因的经验证据仍然有限。可能的原因包括已有的健康状况。这项研究调查了COVID-19疾病严重程度的职业差异,以及它们是否可以归因于已有的健康状况。方法:我们的研究使用了德国健康保险数据,涵盖了317万被保险人(18-67岁),包括2020年和2021年与covid -19相关的住院和死亡率的详细信息,职业信息(重新分为四类)和既往健康状况(分为七个疾病组)。除了描述性统计外,我们估计了具有不同调整集的多变量Cox回归模型。结果:我们发现COVID-19住院率和死亡率存在明显的职业差异,生产部门(特别是制造业)、商业服务部门(特别是清洁部门)和低技能职业的风险最高。在调整了年龄、性别和地区以及其他职业分类后,这些发现仍然存在。我们还发现了一些证据,表明职业和疾病严重程度之间的联系部分可以用先前存在的条件来解释,特别是在低技能水平的情况下。结论:我们的研究结果为COVID-19的职业差异提供了支持,其中所研究的职业分类与风险差异(例如技能水平和工作部门)独立相关。此外,我们提供的经验证据表明,职业技能水平的差异部分是由于预先存在的条件。这一发现表明,在大流行期间,健康方面的职业不平等现象有所加剧,那些健康状况较差、在弱势职业工作的人也更有可能经历严重的COVID-19后果。
{"title":"Can pre-existing medical conditions explain occupational differences in COVID-19 disease severity? An analysis of 3.17 million people insured in Germany.","authors":"Robert Guţu, Valerie Schaps, Benjamin Wachtler, Florian Beese, Jens Hoebel, Marco Alibone, Morten Wahrendorf","doi":"10.5271/sjweh.4242","DOIUrl":"10.5271/sjweh.4242","url":null,"abstract":"<p><strong>Objective: </strong>Occupational differences in COVID-19 are well documented, but the empirical evidence on potential reasons for these differences remains limited. Possible reasons include pre-existing health conditions. This study investigated occupational differences in COVID-19 disease severity and whether they can be attributed to pre-existing health conditions.</p><p><strong>Methods: </strong>Our study used German health insurance data covering 3.17 million insured individuals (age 18-67 years), with details on COVID-19-related hospitalization and mortality in 2020 and 2021, information on occupation (regrouped into four classifications) and pre-existing health conditions (divided into seven disease groups). In addition to descriptive statistics, we estimated multivariable Cox regression models with varying sets of adjustments.</p><p><strong>Results: </strong>We found clear occupational differences in COVID-19 hospitalization and mortality, with the highest risks for the production sector (especially manufacturing), commercial services (especially cleaning) and for low-skilled occupations. These findings persisted after adjusting for age, sex, and region, and also after mutual adjustment for other occupational classifications. We also found some evidence that the association between occupation and disease severity was partly explained by pre-existing conditions, especially in the case of low skill levels.</p><p><strong>Conclusions: </strong>Our findings provide support for occupational differences in COVID-19, where the occupational classifications under study were independently related to risk differences (eg, skill-level and job sector). Furthermore, we provide empirical evidence that differences by occupational skill levels are partly due to pre-existing conditions. This finding suggests that occupational inequalities in health increased during the pandemic, with those with poorer health who worked in disadvantaged occupations also being more likely to experience severe COVID-19 outcomes.</p>","PeriodicalId":21528,"journal":{"name":"Scandinavian journal of work, environment & health","volume":" ","pages":"380-393"},"PeriodicalIF":4.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12412139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144804588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Scandinavian journal of work, environment & health
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