Zihao Bian, Shufen Pan, Ge Sun, Steven G. McNulty, Xingchen Tony Wang, Changchun Huang, Hanqin Tian
Extreme precipitation events, intensified by climate change, are increasingly disrupting nutrient dynamics in large river systems worldwide. Beyond altering the magnitude of individual nutrient fluxes, extreme precipitation may fundamentally reshape nutrient composition and stoichiometric balances, with critical implications for aquatic ecosystem health. Here, we apply an integrated data-model framework to assess how these events have altered nitrogen (N) and phosphorus (P) fluxes across the Mississippi River Basin from 1980 to 2018. We find that extreme rainfall disproportionately increases P export relative to N, driven primarily by enhanced soil erosion and mobilization of particulate-bound nutrients. Concurrent temporal and spatial changes in extreme precipitation regimes have induced declining N:P ratios in headwater streams and cumulative nutrient loads, shifting export stoichiometry toward the Redfield ratio. Therefore, extreme precipitation can increase nutrient fluxes that fuel harmful algal blooms, yet at the same time reduce N:P ratios that may favor less toxic communities. This trade-off calls for watershed management strategies that go beyond managing nutrient quantity alone.
{"title":"Extreme precipitation reshapes nutrient flows and balance in North America’s largest river basin","authors":"Zihao Bian, Shufen Pan, Ge Sun, Steven G. McNulty, Xingchen Tony Wang, Changchun Huang, Hanqin Tian","doi":"10.1126/sciadv.aea3260","DOIUrl":"https://doi.org/10.1126/sciadv.aea3260","url":null,"abstract":"Extreme precipitation events, intensified by climate change, are increasingly disrupting nutrient dynamics in large river systems worldwide. Beyond altering the magnitude of individual nutrient fluxes, extreme precipitation may fundamentally reshape nutrient composition and stoichiometric balances, with critical implications for aquatic ecosystem health. Here, we apply an integrated data-model framework to assess how these events have altered nitrogen (N) and phosphorus (P) fluxes across the Mississippi River Basin from 1980 to 2018. We find that extreme rainfall disproportionately increases P export relative to N, driven primarily by enhanced soil erosion and mobilization of particulate-bound nutrients. Concurrent temporal and spatial changes in extreme precipitation regimes have induced declining N:P ratios in headwater streams and cumulative nutrient loads, shifting export stoichiometry toward the Redfield ratio. Therefore, extreme precipitation can increase nutrient fluxes that fuel harmful algal blooms, yet at the same time reduce N:P ratios that may favor less toxic communities. This trade-off calls for watershed management strategies that go beyond managing nutrient quantity alone.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"45 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147489777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Erratum for the Research Article \"AND-1 is a critical regulator of R-loop dynamics and a target to overcome endocrine resistance\" by Z. Li et al.","authors":"","doi":"10.1126/sciadv.aeg8118","DOIUrl":"https://doi.org/10.1126/sciadv.aeg8118","url":null,"abstract":"","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"13 1","pages":"eaeg8118"},"PeriodicalIF":13.6,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147490055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chengyi Xu, Xufan Li, Lukas Felix Michalek, Jaeho Park, Eunyoung Kim, Zhiyu Zhang, Raymond R. Unocic, Eric Tianjiao Zhao, Wei-Chun Hsu, Baiyu Shi, Shuang Wu, Yang Yang, Avetik R. Harutyunyan, Zhenan Bao
The rapid progress of artificial intelligence (AI) and the internet of things (IoT) has driven growing demand for high-performance, skin-compatible vibration sensors capable of capturing subtle physiological and environmental signals. Low-dimensional materials offer unique advantages in sensitivity and flexibility, yet challenges remain in achieving high strain responsiveness, mechanical robustness, and large-area uniformity. Here, we report an ultrasensitive, low-profile, and stretchable vibration sensor based on large-area single-layer molybdenum disulfide (MoS 2 ) ribbon networks (SLRNs) grown via a vapor-liquid-solid mechanism. Embedding SLRNs within a thermoplastic elastomer [styrene-ethylene-butylene-styrene (SEBS)] yields record-high sensitivity among MoS 2 -based sensors, with gauge factors up to 5300 at <1.6% strain. This response arises from nanocrack-mediated electron transport induced by the thermal expansion mismatch between MoS 2 and SEBS. The ~6-micrometer-thick sensors detect vibrations and acoustic signals over a wide frequency range (>500 hertz), enabling deconvolution of complex stimuli. This work establishes a path toward ultrathin, ultrasensitive wearable sensors for health care and robotic applications.
{"title":"Ultrasensitive soft vibration sensors based on atomically thin metal dichalcogenide ribbon networks","authors":"Chengyi Xu, Xufan Li, Lukas Felix Michalek, Jaeho Park, Eunyoung Kim, Zhiyu Zhang, Raymond R. Unocic, Eric Tianjiao Zhao, Wei-Chun Hsu, Baiyu Shi, Shuang Wu, Yang Yang, Avetik R. Harutyunyan, Zhenan Bao","doi":"10.1126/sciadv.aeb6733","DOIUrl":"https://doi.org/10.1126/sciadv.aeb6733","url":null,"abstract":"The rapid progress of artificial intelligence (AI) and the internet of things (IoT) has driven growing demand for high-performance, skin-compatible vibration sensors capable of capturing subtle physiological and environmental signals. Low-dimensional materials offer unique advantages in sensitivity and flexibility, yet challenges remain in achieving high strain responsiveness, mechanical robustness, and large-area uniformity. Here, we report an ultrasensitive, low-profile, and stretchable vibration sensor based on large-area single-layer molybdenum disulfide (MoS <jats:sub>2</jats:sub> ) ribbon networks (SLRNs) grown via a vapor-liquid-solid mechanism. Embedding SLRNs within a thermoplastic elastomer [styrene-ethylene-butylene-styrene (SEBS)] yields record-high sensitivity among MoS <jats:sub>2</jats:sub> -based sensors, with gauge factors up to 5300 at <1.6% strain. This response arises from nanocrack-mediated electron transport induced by the thermal expansion mismatch between MoS <jats:sub>2</jats:sub> and SEBS. The ~6-micrometer-thick sensors detect vibrations and acoustic signals over a wide frequency range (>500 hertz), enabling deconvolution of complex stimuli. This work establishes a path toward ultrathin, ultrasensitive wearable sensors for health care and robotic applications.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"13 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147489768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Noor Zayanah Hamis, Justin SG Ooi, Ka-Wai Cheung, Valerie Chew, Michaela Gregorova, Eugenia Ziying Ong, Kuan Rong Chan, Tun-Linn Thein, Yee-Sin Leo, David Chien Boon Lye, Eng Eong Ooi, Laura Rivino
Dengue is spreading globally, and there is urgent need to define immune correlates of protection for this disease. Dengue infection first occurs in the skin following the bite of an infected mosquito; however, knowledge of host immune responses within this site remains sparse. We investigated the phenotypic, functional, and transcriptional profiles of skin and blood T cells in 73 patients with dengue and 10 healthy volunteers. We show that the skin T cell compartment undergoes marked reshaping and is strongly enriched with proliferating CD4 + and CD8 + T cells compared with the blood of patients. Activated skin CD8 + T cells expressed a core transcriptional signature of tissue-resident memory T (T RM ) cells, supporting their differentiation to the T RM cell lineage during infection. The magnitude of skin and blood CD8 + T cell responses were associated with protection from hospitalization in this cohort. These data support a protective role of skin-resident and circulating CD8 + T cells in dengue and warrant evaluation of vaccination strategies inducing skin T RM cells to enhance protective immunity.
{"title":"Dengue infection elicits skin tissue-resident and circulating CD8 + T cells associated with protection from hospitalization","authors":"Noor Zayanah Hamis, Justin SG Ooi, Ka-Wai Cheung, Valerie Chew, Michaela Gregorova, Eugenia Ziying Ong, Kuan Rong Chan, Tun-Linn Thein, Yee-Sin Leo, David Chien Boon Lye, Eng Eong Ooi, Laura Rivino","doi":"10.1126/sciadv.aea7987","DOIUrl":"https://doi.org/10.1126/sciadv.aea7987","url":null,"abstract":"Dengue is spreading globally, and there is urgent need to define immune correlates of protection for this disease. Dengue infection first occurs in the skin following the bite of an infected mosquito; however, knowledge of host immune responses within this site remains sparse. We investigated the phenotypic, functional, and transcriptional profiles of skin and blood T cells in 73 patients with dengue and 10 healthy volunteers. We show that the skin T cell compartment undergoes marked reshaping and is strongly enriched with proliferating CD4 <jats:sup>+</jats:sup> and CD8 <jats:sup>+</jats:sup> T cells compared with the blood of patients. Activated skin CD8 <jats:sup>+</jats:sup> T cells expressed a core transcriptional signature of tissue-resident memory T (T <jats:sub>RM</jats:sub> ) cells, supporting their differentiation to the T <jats:sub>RM</jats:sub> cell lineage during infection. The magnitude of skin and blood CD8 <jats:sup>+</jats:sup> T cell responses were associated with protection from hospitalization in this cohort. These data support a protective role of skin-resident and circulating CD8 <jats:sup>+</jats:sup> T cells in dengue and warrant evaluation of vaccination strategies inducing skin T <jats:sub>RM</jats:sub> cells to enhance protective immunity.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"13 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147490014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Junbin Chen, Miao Su, Boya Yu, Mingda Yang, Huiye Wang, Xianzhu Yang, Jun Wang
Therapeutic cancer vaccines show great promise for de novo induction of antigen-specific T cell responses against tumors. However, weak coordination between innate immune activation and antigen delivery remains a major obstacle to vaccine efficacy. Here, we present a cholesterol azetidine derivative–assisted polymeric carrier, Aze-Chol NP, which stimulates innate immunity and primes tumor-specific CD8 + T cell responses. Mechanistically, Aze-Chol NP induces maturation and activation of dendritic cells (DCs) through the Toll-like receptor 9 (TLR9) pathway while simultaneously delivering protein or peptide antigens to DCs in lymph nodes. The Aze-Chol NP–based nanovaccines markedly inhibited tumor growth and prolonged survival in melanoma and human papillomavirus tumor models. Moreover, combining the nanovaccine with an anti–PD-L1 antibody produced a strong synergistic effect and long-term immune memory, achieving 80% survival beyond 100 days and complete rejection of tumor cell rechallenge. Overall, our study demonstrates that this TLR9-activating carrier provides an effective and straightforward strategy for developing potent cancer vaccines.
{"title":"TLR9-activating cholesterol azetidine derivative–assisted therapeutic vaccines for cancer immunotherapy","authors":"Junbin Chen, Miao Su, Boya Yu, Mingda Yang, Huiye Wang, Xianzhu Yang, Jun Wang","doi":"10.1126/sciadv.aeb2465","DOIUrl":"https://doi.org/10.1126/sciadv.aeb2465","url":null,"abstract":"Therapeutic cancer vaccines show great promise for de novo induction of antigen-specific T cell responses against tumors. However, weak coordination between innate immune activation and antigen delivery remains a major obstacle to vaccine efficacy. Here, we present a cholesterol azetidine derivative–assisted polymeric carrier, Aze-Chol NP, which stimulates innate immunity and primes tumor-specific CD8 <jats:sup>+</jats:sup> T cell responses. Mechanistically, Aze-Chol NP induces maturation and activation of dendritic cells (DCs) through the Toll-like receptor 9 (TLR9) pathway while simultaneously delivering protein or peptide antigens to DCs in lymph nodes. The Aze-Chol NP–based nanovaccines markedly inhibited tumor growth and prolonged survival in melanoma and human papillomavirus tumor models. Moreover, combining the nanovaccine with an anti–PD-L1 antibody produced a strong synergistic effect and long-term immune memory, achieving 80% survival beyond 100 days and complete rejection of tumor cell rechallenge. Overall, our study demonstrates that this TLR9-activating carrier provides an effective and straightforward strategy for developing potent cancer vaccines.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"12 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147489734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aleksandra Dagunts, Hayden Adoff, Brandon Novy, Lamya Ben Ameur, Monica De Maria, Arpiar Saunders, Braden T. Lobingier
A critical homeostatic mechanism for regulating G protein–coupled receptor (GPCR) activity is agonist-induced GPCR endocytosis and trafficking to the lysosome for proteolytic down-regulation. The mu opioid receptor (MOR) is a notable example of this type of cellular regulation, where prolonged exposure to high-efficacy opioid drugs causes MOR to traffic to the lysosome. Here, we used functional genomics to identify cellular proteins that control MOR lysosomal down-regulation. We found that the central regulator of MOR postendocytic trafficking is the Retromer complex, which rescues MOR from opioid-induced down-regulation by promoting MOR recycling from endosomes to the plasma membrane. Critically, MOR accesses the Retromer recycling pathway through its noncanonical bileucine recycling motif, and this mechanism controls how MOR is regulated following chronic exposure to opioid drugs. Additionally, we show that this bileucine pathway for Retromer-based recycling is present in other classes of membrane proteins including the glucose transporter GLUT4.
{"title":"Lysosomal down-regulation of the mu opioid receptor is opposed by the Retromer complex","authors":"Aleksandra Dagunts, Hayden Adoff, Brandon Novy, Lamya Ben Ameur, Monica De Maria, Arpiar Saunders, Braden T. Lobingier","doi":"10.1126/sciadv.adx8715","DOIUrl":"https://doi.org/10.1126/sciadv.adx8715","url":null,"abstract":"A critical homeostatic mechanism for regulating G protein–coupled receptor (GPCR) activity is agonist-induced GPCR endocytosis and trafficking to the lysosome for proteolytic down-regulation. The mu opioid receptor (MOR) is a notable example of this type of cellular regulation, where prolonged exposure to high-efficacy opioid drugs causes MOR to traffic to the lysosome. Here, we used functional genomics to identify cellular proteins that control MOR lysosomal down-regulation. We found that the central regulator of MOR postendocytic trafficking is the Retromer complex, which rescues MOR from opioid-induced down-regulation by promoting MOR recycling from endosomes to the plasma membrane. Critically, MOR accesses the Retromer recycling pathway through its noncanonical bileucine recycling motif, and this mechanism controls how MOR is regulated following chronic exposure to opioid drugs. Additionally, we show that this bileucine pathway for Retromer-based recycling is present in other classes of membrane proteins including the glucose transporter GLUT4.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"1 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147489769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rajiv R. Singh, Amani Chinni, Emily Cannistraci, Raul Salinas, Sunny Yadav, Kevin Gozzi, Maria A. Schumacher
DNA damage repair mechanisms are vital for cell survival. In the bacterium, Caulobacter crescentus , DriD is the master regulator of a unique, noncanonical DNA damage pathway. DriD binding to ssDNA, produced upon DNA damage, stimulates its ability to activate transcription from several promoters involved in DNA damage responses. However, the mechanism by which DriD interfaces with the RNAP holoenzyme to activate transcription from its multiple promoters has been unclear. Here, we describe cryo-EM structures of DriD-ssDNA bound to RNAP-holoenzyme and three DriD-regulated promoters. Each subunit of homodimeric DriD contains an DNA binding N -terminal winged helix-turn-helix (wHTH) connected to WYL domains by a linker 3-helix bundle (3HB) module. The structures reveal a mechanism of assembly on promoters whereby DriD’s 3HBs bind the RNAP α-CTD and β domains, anchoring the RNAP-holoenzyme to regulated promoters. The 3HBs form autoinhibitory contacts with DNABDs in apo DriD and therefore acts as an ssDNA-driven trigger domain, switching between DNABD-bound apo and RNAP-bound forms upon ssDNA-mediated activation. Thus, the structures reveal a unique transcription activation mechanism, likely conserved among the large family of homodimeric WYL activators.
{"title":"Transcription activation mechanism of a noncanonical DNA damage response pathway by the WYL-activator, DriD","authors":"Rajiv R. Singh, Amani Chinni, Emily Cannistraci, Raul Salinas, Sunny Yadav, Kevin Gozzi, Maria A. Schumacher","doi":"10.1126/sciadv.aec6337","DOIUrl":"https://doi.org/10.1126/sciadv.aec6337","url":null,"abstract":"DNA damage repair mechanisms are vital for cell survival. In the bacterium, <jats:italic toggle=\"yes\">Caulobacter crescentus</jats:italic> , DriD is the master regulator of a unique, noncanonical DNA damage pathway. DriD binding to ssDNA, produced upon DNA damage, stimulates its ability to activate transcription from several promoters involved in DNA damage responses. However, the mechanism by which DriD interfaces with the RNAP holoenzyme to activate transcription from its multiple promoters has been unclear. Here, we describe cryo-EM structures of DriD-ssDNA bound to RNAP-holoenzyme and three DriD-regulated promoters. Each subunit of homodimeric DriD contains an DNA binding <jats:italic toggle=\"yes\">N</jats:italic> -terminal winged helix-turn-helix (wHTH) connected to WYL domains by a linker 3-helix bundle (3HB) module. The structures reveal a mechanism of assembly on promoters whereby DriD’s 3HBs bind the RNAP α-CTD and β domains, anchoring the RNAP-holoenzyme to regulated promoters. The 3HBs form autoinhibitory contacts with DNABDs in apo DriD and therefore acts as an ssDNA-driven trigger domain, switching between DNABD-bound apo and RNAP-bound forms upon ssDNA-mediated activation. Thus, the structures reveal a unique transcription activation mechanism, likely conserved among the large family of homodimeric WYL activators.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"34 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147489772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lei Zhang, Yuxiang Yang, Hao Yan, Xinlei Ji, Hua An, Jianyu Rao, Yixuan Zhou, Chang-jun Liu, Xi Chen, Ning Yan
Indium oxide (In 2 O 3 ) is a promising catalyst for carbon dioxide (CO 2 ) hydrogenation to methanol but suffers from rapid deactivation due to localized over-reduction of surface In 3+ species into inactive metallic In 0 near hydrogen (H 2 ) activation sites. Here, we exploit a proton-electron dual-transfer mechanism through a physically integrated In 2 O 3 -carbon nanotube (In 2 O 3 -CNT) system, achieving simultaneous enhancement of catalytic performance and durability. The optimal In 2 O 3 -CNT system gives the highest methanol production rate of 1250.6 grams kilograms In2O3−1 hour −1 at 320°C. Particularly, the hybrid system maintains catalytic stability for >500 hours, representing the highest durability among reported In 2 O 3 catalysts. Mechanistic studies and multiple characterization techniques reveal that the conductive CNT network regulates surface redox dynamics by facilitating electron transfer and redistribution. This process promotes the formation of oxygen vacancies for CO 2 activation while preventing localized electron accumulation and In 0 segregation. The CNT-mediated redox modulation stabilizes a dynamic InO x surface phase by balancing H 2 -induced reduction and CO 2 -driven oxidation, thereby sustaining catalytic activity over extended operation.
氧化铟（in2o3）是一种很有前途的催化二氧化碳（CO 2）加氢制甲醇的催化剂，但由于在氢（H 2）活化位点附近，表面的in3 +物种局部过度还原为无活性的金属in0，因此它的失活速度很快。在这里，我们利用质子-电子双转移机制，通过物理集成的In 2o3 -碳纳米管（In 2o3 -CNT）系统，实现了催化性能和耐久性的同时增强。在320℃下，最佳的In2O3 -CNT体系的甲醇产率最高，为1250.6 g kg In2O3−1小时−1。值得一提的是，该混合动力系统可保持500小时的催化稳定性，是目前所报道的In 2o3催化剂中耐久性最高的。机理研究和多种表征技术表明，导电碳纳米管网络通过促进电子转移和再分配来调节表面氧化还原动力学。这一过程促进了CO 2活化的氧空位的形成，同时防止了局部电子积累和In 0偏析。碳纳米管介导的氧化还原调制通过平衡h2诱导的还原和CO 2驱动的氧化来稳定动态的InO x表面相，从而在长时间的操作中保持催化活性。
{"title":"In 2 O 3 -CNT catalysts enable >500-hour stable CO 2 -to-methanol hydrogenation via vacancy stabilization","authors":"Lei Zhang, Yuxiang Yang, Hao Yan, Xinlei Ji, Hua An, Jianyu Rao, Yixuan Zhou, Chang-jun Liu, Xi Chen, Ning Yan","doi":"10.1126/sciadv.aea7041","DOIUrl":"https://doi.org/10.1126/sciadv.aea7041","url":null,"abstract":"Indium oxide (In <jats:sub>2</jats:sub> O <jats:sub>3</jats:sub> ) is a promising catalyst for carbon dioxide (CO <jats:sub>2</jats:sub> ) hydrogenation to methanol but suffers from rapid deactivation due to localized over-reduction of surface In <jats:sup>3+</jats:sup> species into inactive metallic In <jats:sup>0</jats:sup> near hydrogen (H <jats:sub>2</jats:sub> ) activation sites. Here, we exploit a proton-electron dual-transfer mechanism through a physically integrated In <jats:sub>2</jats:sub> O <jats:sub>3</jats:sub> -carbon nanotube (In <jats:sub>2</jats:sub> O <jats:sub>3</jats:sub> -CNT) system, achieving simultaneous enhancement of catalytic performance and durability. The optimal In <jats:sub>2</jats:sub> O <jats:sub>3</jats:sub> -CNT system gives the highest methanol production rate of 1250.6 grams kilograms <jats:sub>In2O3</jats:sub> <jats:sup>−1</jats:sup> hour <jats:sup>−1</jats:sup> at 320°C. Particularly, the hybrid system maintains catalytic stability for >500 hours, representing the highest durability among reported In <jats:sub>2</jats:sub> O <jats:sub>3</jats:sub> catalysts. Mechanistic studies and multiple characterization techniques reveal that the conductive CNT network regulates surface redox dynamics by facilitating electron transfer and redistribution. This process promotes the formation of oxygen vacancies for CO <jats:sub>2</jats:sub> activation while preventing localized electron accumulation and In <jats:sup>0</jats:sup> segregation. The CNT-mediated redox modulation stabilizes a dynamic InO <jats:italic toggle=\"yes\"> <jats:sub>x</jats:sub> </jats:italic> surface phase by balancing H <jats:sub>2</jats:sub> -induced reduction and CO <jats:sub>2</jats:sub> -driven oxidation, thereby sustaining catalytic activity over extended operation.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"35 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147489773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Erratum for the Research Article, \"Cooperative role of distinctive TP53 and PTEN combined loss in the peripheral T cell lymphoma-GATA3 molecular subgroup\" by W.G. Lone et al.","authors":"","doi":"10.1126/sciadv.aeg5995","DOIUrl":"https://doi.org/10.1126/sciadv.aeg5995","url":null,"abstract":"","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 1","pages":"eaeg5995"},"PeriodicalIF":13.6,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147490054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Haoze Sun, Gabriel Alkuino, Yinding Chi, Yevhen Zabila, Haitao Qing, Denys Makarov, Teng Zhang, Jie Yin
Mechanical metamaterials achieve multistep, programmable responses through sequential deformation driven by snapping instabilities, yet these sequences are typically governed by unavoidable imperfections, resulting in random and uncontrollable behavior. Here, we harness intra- and interlayer magnetic interactions coupled with elasticity to reprogram the ordering of sequential buckling instabilities in kirigami-inspired soft magnetic metamaterials. In single-layer systems, intralayer coupling among magnetized units produces random snapping sequences but generates strongly nonlinear-spiked force-displacement responses with pronounced hysteresis, in contrast to the simultaneous buckling of unmagnetized sheets. In multilayer assemblies, interlayer magnetic interactions trigger chain reaction–like propagation, transforming randomness into robust, directional snapping across structures. This mechanism establishes a paradigm for deterministic, multistep mechanical responses without continuously applied fields and opens avenues for adaptive materials in energy dissipation, waveguiding, reconfigurable soft robotics, and biomedical devices.
{"title":"Magnetic coupling transforms random snapping into ordered sequences in soft metamaterials","authors":"Haoze Sun, Gabriel Alkuino, Yinding Chi, Yevhen Zabila, Haitao Qing, Denys Makarov, Teng Zhang, Jie Yin","doi":"10.1126/sciadv.aec3182","DOIUrl":"https://doi.org/10.1126/sciadv.aec3182","url":null,"abstract":"Mechanical metamaterials achieve multistep, programmable responses through sequential deformation driven by snapping instabilities, yet these sequences are typically governed by unavoidable imperfections, resulting in random and uncontrollable behavior. Here, we harness intra- and interlayer magnetic interactions coupled with elasticity to reprogram the ordering of sequential buckling instabilities in kirigami-inspired soft magnetic metamaterials. In single-layer systems, intralayer coupling among magnetized units produces random snapping sequences but generates strongly nonlinear-spiked force-displacement responses with pronounced hysteresis, in contrast to the simultaneous buckling of unmagnetized sheets. In multilayer assemblies, interlayer magnetic interactions trigger chain reaction–like propagation, transforming randomness into robust, directional snapping across structures. This mechanism establishes a paradigm for deterministic, multistep mechanical responses without continuously applied fields and opens avenues for adaptive materials in energy dissipation, waveguiding, reconfigurable soft robotics, and biomedical devices.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"85 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147489738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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