Juliette Espanet, Xiaoning He, Ting Pan, Naomie Gentric, Thomas Potuschak, Bénédicte Desvoyes, Philippe Hammann, Johana Chicher, Rim Brik, Esther Lechner, David Latrasse, Aladár Pettkó-Szandtner, Crisanto Gutierrez, Cécile Raynaud, Zoltán Magyar, Moussa Benhamed, Shunping Yan, Sandra Noir, Pascal Genschik
F-box proteins of SCF E3 ligases have been documented to control the abundance of numerous critical regulatory proteins. In Arabidopsis , one of them, F-BOX-LIKE17 (FBL17), stands out for playing a key role in DNA replication, DNA damage, and, more recently, for the control of cell size. FBL17 null mutants exhibit severe cellular defects leading to lethality. However, the molecular mechanisms by which FBL17 operate remain poorly understood. Here, we show that FBL17 interacts with different components of the RETINOBLASTOMA-RELATED1/E2F module and is involved in the protein turnover of E2Fa and E2Fb. However, mutations in E2Fa or E2Fb do not alleviate the severe fbl17 phenotype but worsen it. By contrast, it is the accumulation of the transcriptional repressor E2Fc that causes fbl17 mutant lethality. Our results highlight a key role for FBL17 in modulating the transcriptional control of E2F target genes ensuring precise control of cell cycle progression and avoiding uncontrolled DNA damage response.
{"title":"Tuning of the RBR1-E2F/DP transcriptional module by the F-box protein FBL17","authors":"Juliette Espanet, Xiaoning He, Ting Pan, Naomie Gentric, Thomas Potuschak, Bénédicte Desvoyes, Philippe Hammann, Johana Chicher, Rim Brik, Esther Lechner, David Latrasse, Aladár Pettkó-Szandtner, Crisanto Gutierrez, Cécile Raynaud, Zoltán Magyar, Moussa Benhamed, Shunping Yan, Sandra Noir, Pascal Genschik","doi":"10.1126/sciadv.adz2439","DOIUrl":"https://doi.org/10.1126/sciadv.adz2439","url":null,"abstract":"F-box proteins of SCF E3 ligases have been documented to control the abundance of numerous critical regulatory proteins. In <jats:italic toggle=\"yes\">Arabidopsis</jats:italic> , one of them, F-BOX-LIKE17 (FBL17), stands out for playing a key role in DNA replication, DNA damage, and, more recently, for the control of cell size. <jats:italic toggle=\"yes\">FBL17</jats:italic> null mutants exhibit severe cellular defects leading to lethality. However, the molecular mechanisms by which FBL17 operate remain poorly understood. Here, we show that FBL17 interacts with different components of the RETINOBLASTOMA-RELATED1/E2F module and is involved in the protein turnover of E2Fa and E2Fb. However, mutations in <jats:italic toggle=\"yes\">E2Fa</jats:italic> or <jats:italic toggle=\"yes\">E2Fb</jats:italic> do not alleviate the severe <jats:italic toggle=\"yes\">fbl17</jats:italic> phenotype but worsen it. By contrast, it is the accumulation of the transcriptional repressor E2Fc that causes <jats:italic toggle=\"yes\">fbl17</jats:italic> mutant lethality. Our results highlight a key role for FBL17 in modulating the transcriptional control of E2F target genes ensuring precise control of cell cycle progression and avoiding uncontrolled DNA damage response.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146210440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Children with congenital heart valve disease require repeat surgical procedures to resize grafts. A new option is a valved stent that grows spontaneously.
患有先天性心脏瓣膜疾病的儿童需要重复手术来调整移植物的大小。一种新的选择是一种自发生长的带瓣支架。
{"title":"Engineering surgery-free prosthetic heart valve growth","authors":"Jonathan T. Butcher","doi":"","DOIUrl":"","url":null,"abstract":"<div >Children with congenital heart valve disease require repeat surgical procedures to resize grafts. A new option is a valved stent that grows spontaneously.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"12 8","pages":""},"PeriodicalIF":12.5,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146211428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Peter S. Back, Erinn Wagner, Paula Montero Llopis, Ramon G. de Oliveira, Marco Mottinelli, Lori Ferrins, Jeffrey D. Dvorin
Asexual reproduction of malaria parasites requires the basal complex, the equivalent of a eukaryotic contractile ring. Despite its central role, basal complex biogenesis remains largely unknown. Here, we use expansion microscopy and DNA points accumulation for imaging in nanoscale topography to investigate three transmembrane basal complex proteins in Plasmodium falciparum—basal complex transmembrane protein 1 (BTP1), BTP2, and basolateral expansion boundary (BLEB). Parasites lacking BTP2 are still enveloped by membranes but fail to separate from each other, resulting in multiorganellar mutants. We isolate the defect to a specific step during basal complex development and demonstrate that the contractile ability remains intact. By revisiting BLEB, we identify a distinct plasma membrane region that is excluded from daughter cells and associated with the basal complex. Integrating these findings, we propose a three-step model for basal complex biogenesis that highlights the specific role of BTP2 and suggests a role for the BLEB-associated membrane. This study offers a mechanistic framework for how multiple daughter cells are formed simultaneously and highlights the importance of transmembrane proteins for cell division.
{"title":"Transmembrane proteins mediate basal complex assembly and individual daughter cell formation in malaria parasites","authors":"Peter S. Back, Erinn Wagner, Paula Montero Llopis, Ramon G. de Oliveira, Marco Mottinelli, Lori Ferrins, Jeffrey D. Dvorin","doi":"","DOIUrl":"","url":null,"abstract":"<div >Asexual reproduction of malaria parasites requires the basal complex, the equivalent of a eukaryotic contractile ring. Despite its central role, basal complex biogenesis remains largely unknown. Here, we use expansion microscopy and DNA points accumulation for imaging in nanoscale topography to investigate three transmembrane basal complex proteins in <i>Plasmodium falciparum</i>—basal complex transmembrane protein 1 (BTP1), BTP2, and basolateral expansion boundary (BLEB). Parasites lacking BTP2 are still enveloped by membranes but fail to separate from each other, resulting in multiorganellar mutants. We isolate the defect to a specific step during basal complex development and demonstrate that the contractile ability remains intact. By revisiting BLEB, we identify a distinct plasma membrane region that is excluded from daughter cells and associated with the basal complex. Integrating these findings, we propose a three-step model for basal complex biogenesis that highlights the specific role of BTP2 and suggests a role for the BLEB-associated membrane. This study offers a mechanistic framework for how multiple daughter cells are formed simultaneously and highlights the importance of transmembrane proteins for cell division.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"12 8","pages":""},"PeriodicalIF":12.5,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146211429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Peter S. Back, Erinn Wagner, Paula Montero Llopis, Ramon G. de Oliveira, Marco Mottinelli, Lori Ferrins, Jeffrey D. Dvorin
Asexual reproduction of malaria parasites requires the basal complex, the equivalent of a eukaryotic contractile ring. Despite its central role, basal complex biogenesis remains largely unknown. Here, we use expansion microscopy and DNA points accumulation for imaging in nanoscale topography to investigate three transmembrane basal complex proteins in Plasmodium falciparum —basal complex transmembrane protein 1 (BTP1), BTP2, and basolateral expansion boundary (BLEB). Parasites lacking BTP2 are still enveloped by membranes but fail to separate from each other, resulting in multiorganellar mutants. We isolate the defect to a specific step during basal complex development and demonstrate that the contractile ability remains intact. By revisiting BLEB, we identify a distinct plasma membrane region that is excluded from daughter cells and associated with the basal complex. Integrating these findings, we propose a three-step model for basal complex biogenesis that highlights the specific role of BTP2 and suggests a role for the BLEB-associated membrane. This study offers a mechanistic framework for how multiple daughter cells are formed simultaneously and highlights the importance of transmembrane proteins for cell division.
{"title":"Transmembrane proteins mediate basal complex assembly and individual daughter cell formation in malaria parasites","authors":"Peter S. Back, Erinn Wagner, Paula Montero Llopis, Ramon G. de Oliveira, Marco Mottinelli, Lori Ferrins, Jeffrey D. Dvorin","doi":"10.1126/sciadv.aeb5163","DOIUrl":"https://doi.org/10.1126/sciadv.aeb5163","url":null,"abstract":"Asexual reproduction of malaria parasites requires the basal complex, the equivalent of a eukaryotic contractile ring. Despite its central role, basal complex biogenesis remains largely unknown. Here, we use expansion microscopy and DNA points accumulation for imaging in nanoscale topography to investigate three transmembrane basal complex proteins in <jats:italic toggle=\"yes\">Plasmodium falciparum</jats:italic> —basal complex transmembrane protein 1 (BTP1), BTP2, and basolateral expansion boundary (BLEB). Parasites lacking BTP2 are still enveloped by membranes but fail to separate from each other, resulting in multiorganellar mutants. We isolate the defect to a specific step during basal complex development and demonstrate that the contractile ability remains intact. By revisiting BLEB, we identify a distinct plasma membrane region that is excluded from daughter cells and associated with the basal complex. Integrating these findings, we propose a three-step model for basal complex biogenesis that highlights the specific role of BTP2 and suggests a role for the BLEB-associated membrane. This study offers a mechanistic framework for how multiple daughter cells are formed simultaneously and highlights the importance of transmembrane proteins for cell division.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"5 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146210012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alexandros Gelastopoulos, Pantelis P. Analytis, Gaël Le Mens, Arnout van de Rijt
People are influenced by the choices of others, a phenomenon observed across contexts in the social and behavioral sciences. Social influence can lock in an initial popularity advantage of an option over a higher quality alternative. Yet, several experiments designed to enable social influence have found that social systems self-correct rather than lock in. Here, we identify a behavioral phenomenon that makes inferior lock-in possible, which we call the “marginal majority effect”: a discontinuous increase in the choice probability of an option as its popularity exceeds that of a competing option. We demonstrate the existence of a marginal majority effect in several recent experiments and show that lock-in always occurs when the effect is large enough to offset the quality effect on choice but rarely otherwise. Our results reconcile conflicting past empirical evidence and connect a behavioral phenomenon to the possibility of social lock-in.
{"title":"The marginal majority effect: When social influence produces lock-in","authors":"Alexandros Gelastopoulos, Pantelis P. Analytis, Gaël Le Mens, Arnout van de Rijt","doi":"10.1126/sciadv.adr4237","DOIUrl":"https://doi.org/10.1126/sciadv.adr4237","url":null,"abstract":"People are influenced by the choices of others, a phenomenon observed across contexts in the social and behavioral sciences. Social influence can lock in an initial popularity advantage of an option over a higher quality alternative. Yet, several experiments designed to enable social influence have found that social systems self-correct rather than lock in. Here, we identify a behavioral phenomenon that makes inferior lock-in possible, which we call the “marginal majority effect”: a discontinuous increase in the choice probability of an option as its popularity exceeds that of a competing option. We demonstrate the existence of a marginal majority effect in several recent experiments and show that lock-in always occurs when the effect is large enough to offset the quality effect on choice but rarely otherwise. Our results reconcile conflicting past empirical evidence and connect a behavioral phenomenon to the possibility of social lock-in.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"199 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146210017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lingqi Tang, Yongzun Yang, Bing Li, Bingfu Zhang, Qiguang He, Hongliang Ren, Yao Li
Centimeter-scale amphibious robots are promising for versatile tasks. Existing solutions use active and multiple mechanisms for environmental interaction; however, such designs face sealing challenges at small scales and are often complex and unreliable. Here, we present an inertia-driven actuation strategy combining a variable-output voice coil motor (VCM) with a fully sealed rigid shell. By modulating the VCM output, the robot achieves jumping, full-stroke vibration for terrestrial locomotion and small-stroke vibration for aquatic propulsion. Terrestrial tests demonstrate rapid motion on granular media, continuous jumping, and load carrying. The robot also uses passive tilted fins that convert reciprocating motion into steerable aquatic thrust, realizing an inertia-driven multidirectional propulsion mechanism. Thrust generation and frequency-dependent propulsion were analyzed through aquatic experiments, high-speed particle image velocimetry, and simulations. Last, a 24-gram legless prototype (Leglessbot) demonstrated effective locomotion across diverse terrain, offering a compact solution for underactuated amphibious mobility.
{"title":"Inertia-driven amphibious robot with asymmetric microundulatory fin arrays","authors":"Lingqi Tang, Yongzun Yang, Bing Li, Bingfu Zhang, Qiguang He, Hongliang Ren, Yao Li","doi":"10.1126/sciadv.aea2222","DOIUrl":"https://doi.org/10.1126/sciadv.aea2222","url":null,"abstract":"Centimeter-scale amphibious robots are promising for versatile tasks. Existing solutions use active and multiple mechanisms for environmental interaction; however, such designs face sealing challenges at small scales and are often complex and unreliable. Here, we present an inertia-driven actuation strategy combining a variable-output voice coil motor (VCM) with a fully sealed rigid shell. By modulating the VCM output, the robot achieves jumping, full-stroke vibration for terrestrial locomotion and small-stroke vibration for aquatic propulsion. Terrestrial tests demonstrate rapid motion on granular media, continuous jumping, and load carrying. The robot also uses passive tilted fins that convert reciprocating motion into steerable aquatic thrust, realizing an inertia-driven multidirectional propulsion mechanism. Thrust generation and frequency-dependent propulsion were analyzed through aquatic experiments, high-speed particle image velocimetry, and simulations. Last, a 24-gram legless prototype (Leglessbot) demonstrated effective locomotion across diverse terrain, offering a compact solution for underactuated amphibious mobility.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"280 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146210436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The scale and timing of genetic contributions from ancient millet- and rice-farming populations in China to Southeast Asian populations remain incompletely understood, particularly concerning Y-chromosome diversity. Here, a comprehensive dataset of Chinese Y-chromosome variations, including 1507 high-coverage sequences from ethnolinguistically diverse groups, was analyzed alongside 780 ancient genomes from eastern Eurasia and 1748 low-coverage sequences from Southeast Asia. We reconstructed a high-resolution, time-calibrated Y-chromosome phylogeny, revealing multiple male-biased expansions associated with Neolithic cultural innovations in South China. These expansions markedly shaped the paternal ancestry of both South China and mainland Southeast Asia. Founding lineages linked to Hmong-Mien and Tai-Kadai speakers were traced, revealing notable growth during the Middle Neolithic. Phylogeographic structure, network analyses, and haplogroup distributions indicate complex demographic interactions that established the genetic legacy of Neolithic farmers in Southeast Asia. These findings highlight recurrent southward migrations of Chinese farmer-related groups and their enduring influence on the paternal genetic landscape of ancient and present-day Southeast Asians.
{"title":"Multiple southward migrations of Neolithic Chinese farmers into Southeast Asia revealed from large-scale Y-chromosome sequences","authors":"Mengge Wang, Yunhui Liu, Lintao Luo, Zhiyong Wang, Yuhang Feng, Ting Yang, Jing Chen, Yufeng Liu, Yuguo Huang, Qiuxia Sun, Shuhan Duan, Xinyu Lin, Jie Zhong, Bowen Li, Kaijun Liu, Haibing Yuan, Chao Liu, Renkuan Tang, Guanglin He","doi":"10.1126/sciadv.ady1597","DOIUrl":"https://doi.org/10.1126/sciadv.ady1597","url":null,"abstract":"The scale and timing of genetic contributions from ancient millet- and rice-farming populations in China to Southeast Asian populations remain incompletely understood, particularly concerning Y-chromosome diversity. Here, a comprehensive dataset of Chinese Y-chromosome variations, including 1507 high-coverage sequences from ethnolinguistically diverse groups, was analyzed alongside 780 ancient genomes from eastern Eurasia and 1748 low-coverage sequences from Southeast Asia. We reconstructed a high-resolution, time-calibrated Y-chromosome phylogeny, revealing multiple male-biased expansions associated with Neolithic cultural innovations in South China. These expansions markedly shaped the paternal ancestry of both South China and mainland Southeast Asia. Founding lineages linked to Hmong-Mien and Tai-Kadai speakers were traced, revealing notable growth during the Middle Neolithic. Phylogeographic structure, network analyses, and haplogroup distributions indicate complex demographic interactions that established the genetic legacy of Neolithic farmers in Southeast Asia. These findings highlight recurrent southward migrations of Chinese farmer-related groups and their enduring influence on the paternal genetic landscape of ancient and present-day Southeast Asians.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"17 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146210438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vaults are some of the largest ribonucleoprotein complexes known and are highly conserved across eukaryotes, but both their function and key details of their architecture remain unclear. While high-resolution structures of the vault shell are available, the architecture and symmetry of the cap have remained unresolved. Here, we present a 2.25-angstrom cryo–electron microscopy structure of the vault cap, revealing an unexpected 13-fold symmetric arrangement that contrasts with the 39-fold symmetry of the vault body, with each repeating module of the cap formed by an asymmetric homotrimer of adjacent subunits. The center of the cap features an unusual architecture, consisting of two concentric β barrels surrounded by an interwoven two-layer stack of α helices. The vault cap features a positively charged exterior and a negatively charged interior surface, with implications for binding partner recruitment and engineering of modified vault particles.
{"title":"The vault particle is enclosed by a C13-symmetric cap with a positively charged exterior","authors":"Huan Li, Francesca Vallese, Oliver B. Clarke","doi":"","DOIUrl":"","url":null,"abstract":"<div >Vaults are some of the largest ribonucleoprotein complexes known and are highly conserved across eukaryotes, but both their function and key details of their architecture remain unclear. While high-resolution structures of the vault shell are available, the architecture and symmetry of the cap have remained unresolved. Here, we present a 2.25-angstrom cryo–electron microscopy structure of the vault cap, revealing an unexpected 13-fold symmetric arrangement that contrasts with the 39-fold symmetry of the vault body, with each repeating module of the cap formed by an asymmetric homotrimer of adjacent subunits. The center of the cap features an unusual architecture, consisting of two concentric β barrels surrounded by an interwoven two-layer stack of α helices. The vault cap features a positively charged exterior and a negatively charged interior surface, with implications for binding partner recruitment and engineering of modified vault particles.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"12 8","pages":""},"PeriodicalIF":12.5,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146211410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heng Zhang, Yi Chen, Gangsheng Chen, Wuxing Zhang, Cheng Yang, Fan Zhou, Yunqi Zhao, Haoran Deng, Xuan Huang, Yuan An, Guoqun Li, Shuqi Tang, Biao Ma, Wenlong Cheng, Ning Gu
We introduce a morphology-adaptive Au-Ag nanowire elastronic platform that conforms to diverse geometries while enabling multimodal optical-electrical sensing. Using a facile yet versatile template-guided growth strategy, vertically aligned Au-Ag nanowire arrays are directly fabricated on 1D nano/microneedles, 2D elastic films, and 3D porous architectures. On 2D substrates, the arrays act as FlexoSERS interfaces with high sensitivity, uniformity (RSD = 7.2%), and durability, maintaining stable SERS signals under 100% strain and after 2500 cycles. On 3D porous sponges, the NWs serve as dry bioelectrical electrodes, enabling stable electrocardiogram (ECG) and electromyogram (EMG) monitoring with long-term stability. Continuous ECG recording, combined with deep learning analysis, enables accurate classification between sleep and wake states. Meanwhile, the EMG signals capture subtle motor activities such as finger bending, typing, and clicking. By uniting strain-tolerant FlexoSERS with reliable bioelectrical sensing across 1D-3D substrates, this platform provides a robust material foundation and a scalable route toward next-generation wearable health monitors, intelligent sleep evaluation, and human-machine interfaces.
{"title":"Morphology-adaptive Au-Ag nanowire elastronics for integrated FlexoSERS and bioelectrical sensing","authors":"Heng Zhang, Yi Chen, Gangsheng Chen, Wuxing Zhang, Cheng Yang, Fan Zhou, Yunqi Zhao, Haoran Deng, Xuan Huang, Yuan An, Guoqun Li, Shuqi Tang, Biao Ma, Wenlong Cheng, Ning Gu","doi":"","DOIUrl":"","url":null,"abstract":"<div >We introduce a morphology-adaptive Au-Ag nanowire elastronic platform that conforms to diverse geometries while enabling multimodal optical-electrical sensing. Using a facile yet versatile template-guided growth strategy, vertically aligned Au-Ag nanowire arrays are directly fabricated on 1D nano/microneedles, 2D elastic films, and 3D porous architectures. On 2D substrates, the arrays act as FlexoSERS interfaces with high sensitivity, uniformity (RSD = 7.2%), and durability, maintaining stable SERS signals under 100% strain and after 2500 cycles. On 3D porous sponges, the NWs serve as dry bioelectrical electrodes, enabling stable electrocardiogram (ECG) and electromyogram (EMG) monitoring with long-term stability. Continuous ECG recording, combined with deep learning analysis, enables accurate classification between sleep and wake states. Meanwhile, the EMG signals capture subtle motor activities such as finger bending, typing, and clicking. By uniting strain-tolerant FlexoSERS with reliable bioelectrical sensing across 1D-3D substrates, this platform provides a robust material foundation and a scalable route toward next-generation wearable health monitors, intelligent sleep evaluation, and human-machine interfaces.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"12 8","pages":""},"PeriodicalIF":12.5,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146211416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aneuploidy is present in about 90% human solid tumors. Certain tumors remain addicted to aneuploidy. Paradoxically, artificially induced aneuploidy in normal cells elicits cellular stresses and decreases cell fitness. How aneuploidy initially emerges during tumorigenesis is thus unclear. Using human embryonic stem cells (ESCs) as a model, we show that aneuploid ESCs form immature teratomas with an enrichment of mesenchymal tissues. Specifically, chromosome 8 (chr8) gain, a prevalent form of aneuploidy in human cancers, promotes the expansion of mesenchymal stem cells (MSCs) in teratomas and MSC proliferation in vitro. We further show that human embryonal rhabdomyosarcomas, tumors of mesenchymal origin, lack dominant driver mutations but frequently harbor chr8 gain. Our study suggests a plausible mechanism for aneuploidy emergence during tumorigenesis, links specific aneuploidy to the mesenchymal lineage, and paves the way for identifying vulnerabilities of aneuploid MSCs, which may have important roles in tumorigenesis.
{"title":"Aneuploidy of chromosome 8 promotes the mesenchymal lineage during cell fate transitions","authors":"Cai Liang, Guanchen Li, Qiuqin Zhang, Xinlei Wang, Yu Liu, Wenjuan Yin, Ting Tao, Jinhu Wang, Haishan Gao, Shutao Qi, Hongtao Yu","doi":"10.1126/sciadv.aea1660","DOIUrl":"https://doi.org/10.1126/sciadv.aea1660","url":null,"abstract":"Aneuploidy is present in about 90% human solid tumors. Certain tumors remain addicted to aneuploidy. Paradoxically, artificially induced aneuploidy in normal cells elicits cellular stresses and decreases cell fitness. How aneuploidy initially emerges during tumorigenesis is thus unclear. Using human embryonic stem cells (ESCs) as a model, we show that aneuploid ESCs form immature teratomas with an enrichment of mesenchymal tissues. Specifically, chromosome 8 (chr8) gain, a prevalent form of aneuploidy in human cancers, promotes the expansion of mesenchymal stem cells (MSCs) in teratomas and MSC proliferation in vitro. We further show that human embryonal rhabdomyosarcomas, tumors of mesenchymal origin, lack dominant driver mutations but frequently harbor chr8 gain. Our study suggests a plausible mechanism for aneuploidy emergence during tumorigenesis, links specific aneuploidy to the mesenchymal lineage, and paves the way for identifying vulnerabilities of aneuploid MSCs, which may have important roles in tumorigenesis.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"124 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146210298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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