Juliette Espanet, Xiaoning He, Ting Pan, Naomie Gentric, Thomas Potuschak, Bénédicte Desvoyes, Philippe Hammann, Johana Chicher, Rim Brik, Esther Lechner, David Latrasse, Aladár Pettkó-Szandtner, Crisanto Gutierrez, Cécile Raynaud, Zoltán Magyar, Moussa Benhamed, Shunping Yan, Sandra Noir, Pascal Genschik
F-box proteins of SCF E3 ligases have been documented to control the abundance of numerous critical regulatory proteins. In Arabidopsis, one of them, F-BOX-LIKE17 (FBL17), stands out for playing a key role in DNA replication, DNA damage, and, more recently, for the control of cell size. FBL17 null mutants exhibit severe cellular defects leading to lethality. However, the molecular mechanisms by which FBL17 operate remain poorly understood. Here, we show that FBL17 interacts with different components of the RETINOBLASTOMA-RELATED1/E2F module and is involved in the protein turnover of E2Fa and E2Fb. However, mutations in E2Fa or E2Fb do not alleviate the severe fbl17 phenotype but worsen it. By contrast, it is the accumulation of the transcriptional repressor E2Fc that causes fbl17 mutant lethality. Our results highlight a key role for FBL17 in modulating the transcriptional control of E2F target genes ensuring precise control of cell cycle progression and avoiding uncontrolled DNA damage response.
{"title":"Tuning of the RBR1-E2F/DP transcriptional module by the F-box protein FBL17","authors":"Juliette Espanet, Xiaoning He, Ting Pan, Naomie Gentric, Thomas Potuschak, Bénédicte Desvoyes, Philippe Hammann, Johana Chicher, Rim Brik, Esther Lechner, David Latrasse, Aladár Pettkó-Szandtner, Crisanto Gutierrez, Cécile Raynaud, Zoltán Magyar, Moussa Benhamed, Shunping Yan, Sandra Noir, Pascal Genschik","doi":"","DOIUrl":"","url":null,"abstract":"<div >F-box proteins of SCF E3 ligases have been documented to control the abundance of numerous critical regulatory proteins. In <i>Arabidopsis</i>, one of them, F-BOX-LIKE17 (FBL17), stands out for playing a key role in DNA replication, DNA damage, and, more recently, for the control of cell size. <i>FBL17</i> null mutants exhibit severe cellular defects leading to lethality. However, the molecular mechanisms by which FBL17 operate remain poorly understood. Here, we show that FBL17 interacts with different components of the RETINOBLASTOMA-RELATED1/E2F module and is involved in the protein turnover of E2Fa and E2Fb. However, mutations in <i>E2Fa</i> or <i>E2Fb</i> do not alleviate the severe <i>fbl17</i> phenotype but worsen it. By contrast, it is the accumulation of the transcriptional repressor E2Fc that causes <i>fbl17</i> mutant lethality. Our results highlight a key role for FBL17 in modulating the transcriptional control of E2F target genes ensuring precise control of cell cycle progression and avoiding uncontrolled DNA damage response.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"12 8","pages":""},"PeriodicalIF":12.5,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146211419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luis Alonso Baez, Astrid Bjørkøy, Francesco Saffioti, Sara Morghen, Dhika Amanda, Michaela Tichá, Maarten Besten, Anastasiia Ivanova, Joris Sprakel, Bjørn Torger Stokke, Thorsten Hamann
Mechanical properties of plant cells and tissues change dynamically, influencing plant growth, development, and interactions with the environment. Despite their central roles in plant life, current knowledge of how these properties change in vivo is very limited. Here, we have combined Brillouin microscopy and molecular rotors to investigate stiffness, viscosity, and porosity in living Arabidopsis thaliana seedling roots during differentiation and in response to stress and genetic manipulation. We found that mechanical properties change in a cell- and tissue-specific manner. The properties change dynamically during differentiation to support directional cell expansion. Cell type–specific adaptation of the properties is induced within hours in response to stress or changes in cell wall metabolism. Hyperosmotic stress–induced reduction of cell wall stiffness requires intact abscisic acid metabolism and cell wall integrity signaling. The findings form the foundation for future studies to characterize the regulatory mechanisms linking cell wall homeostasis, signaling, and mechanical properties in plants.
{"title":"The mechanical properties of Arabidopsis thaliana roots adapt dynamically during development and to stress","authors":"Luis Alonso Baez, Astrid Bjørkøy, Francesco Saffioti, Sara Morghen, Dhika Amanda, Michaela Tichá, Maarten Besten, Anastasiia Ivanova, Joris Sprakel, Bjørn Torger Stokke, Thorsten Hamann","doi":"","DOIUrl":"","url":null,"abstract":"<div >Mechanical properties of plant cells and tissues change dynamically, influencing plant growth, development, and interactions with the environment. Despite their central roles in plant life, current knowledge of how these properties change in vivo is very limited. Here, we have combined Brillouin microscopy and molecular rotors to investigate stiffness, viscosity, and porosity in living <i>Arabidopsis thaliana</i> seedling roots during differentiation and in response to stress and genetic manipulation. We found that mechanical properties change in a cell- and tissue-specific manner. The properties change dynamically during differentiation to support directional cell expansion. Cell type–specific adaptation of the properties is induced within hours in response to stress or changes in cell wall metabolism. Hyperosmotic stress–induced reduction of cell wall stiffness requires intact abscisic acid metabolism and cell wall integrity signaling. The findings form the foundation for future studies to characterize the regulatory mechanisms linking cell wall homeostasis, signaling, and mechanical properties in plants.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"12 8","pages":""},"PeriodicalIF":12.5,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146211420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heng Zhang, Yi Chen, Gangsheng Chen, Wuxing Zhang, Cheng Yang, Fan Zhou, Yunqi Zhao, Haoran Deng, Xuan Huang, Yuan An, Guoqun Li, Shuqi Tang, Biao Ma, Wenlong Cheng, Ning Gu
We introduce a morphology-adaptive Au-Ag nanowire elastronic platform that conforms to diverse geometries while enabling multimodal optical-electrical sensing. Using a facile yet versatile template-guided growth strategy, vertically aligned Au-Ag nanowire arrays are directly fabricated on 1D nano/microneedles, 2D elastic films, and 3D porous architectures. On 2D substrates, the arrays act as FlexoSERS interfaces with high sensitivity, uniformity (RSD = 7.2%), and durability, maintaining stable SERS signals under 100% strain and after 2500 cycles. On 3D porous sponges, the NWs serve as dry bioelectrical electrodes, enabling stable electrocardiogram (ECG) and electromyogram (EMG) monitoring with long-term stability. Continuous ECG recording, combined with deep learning analysis, enables accurate classification between sleep and wake states. Meanwhile, the EMG signals capture subtle motor activities such as finger bending, typing, and clicking. By uniting strain-tolerant FlexoSERS with reliable bioelectrical sensing across 1D-3D substrates, this platform provides a robust material foundation and a scalable route toward next-generation wearable health monitors, intelligent sleep evaluation, and human-machine interfaces.
{"title":"Morphology-adaptive Au-Ag nanowire elastronics for integrated FlexoSERS and bioelectrical sensing","authors":"Heng Zhang, Yi Chen, Gangsheng Chen, Wuxing Zhang, Cheng Yang, Fan Zhou, Yunqi Zhao, Haoran Deng, Xuan Huang, Yuan An, Guoqun Li, Shuqi Tang, Biao Ma, Wenlong Cheng, Ning Gu","doi":"10.1126/sciadv.aec2162","DOIUrl":"https://doi.org/10.1126/sciadv.aec2162","url":null,"abstract":"We introduce a morphology-adaptive Au-Ag nanowire elastronic platform that conforms to diverse geometries while enabling multimodal optical-electrical sensing. Using a facile yet versatile template-guided growth strategy, vertically aligned Au-Ag nanowire arrays are directly fabricated on 1D nano/microneedles, 2D elastic films, and 3D porous architectures. On 2D substrates, the arrays act as FlexoSERS interfaces with high sensitivity, uniformity (RSD = 7.2%), and durability, maintaining stable SERS signals under 100% strain and after 2500 cycles. On 3D porous sponges, the NWs serve as dry bioelectrical electrodes, enabling stable electrocardiogram (ECG) and electromyogram (EMG) monitoring with long-term stability. Continuous ECG recording, combined with deep learning analysis, enables accurate classification between sleep and wake states. Meanwhile, the EMG signals capture subtle motor activities such as finger bending, typing, and clicking. By uniting strain-tolerant FlexoSERS with reliable bioelectrical sensing across 1D-3D substrates, this platform provides a robust material foundation and a scalable route toward next-generation wearable health monitors, intelligent sleep evaluation, and human-machine interfaces.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"52 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146210016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Children with congenital heart valve disease require repeat surgical procedures to resize grafts. A new option is a valved stent that grows spontaneously.
患有先天性心脏瓣膜疾病的儿童需要重复手术来调整移植物的大小。一种新的选择是一种自发生长的带瓣支架。
{"title":"Engineering surgery-free prosthetic heart valve growth","authors":"Jonathan T. Butcher","doi":"10.1126/sciadv.aef4597","DOIUrl":"https://doi.org/10.1126/sciadv.aef4597","url":null,"abstract":"Children with congenital heart valve disease require repeat surgical procedures to resize grafts. A new option is a valved stent that grows spontaneously.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"30 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146210300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The Madden-Julian oscillation (MJO) is a planetary-scale tropical weather disturbance marked by eastward-propagating cumulus cloud clusters over the Indo-Pacific region, causing severe weather and climate events worldwide. The mechanism and predictability of MJO propagation remain elusive, partly because relevant multiscale processes are poorly understood. Here, we reveal chaotic MJO propagation arising from cross-scale nonlinear interactions, based on 4000-member ensemble simulations of two MJO events with a global cloud-system–resolving model. Against conventional linear thinking, multiple regimes with distinct timings of MJO propagation emerge under a single atmosphere-ocean background. The emergence of regime bifurcation depends critically on the equatorial asymmetry of climatological sea surface temperature. Selection of the bifurcated regimes is probabilistic, influenced by whether tropical-extratropical interplay promotes moistening associated with westward-propagating tropical waves over the western Pacific. These results contribute to a more complete MJO conceptual model and help foresee when coherent MJO propagation emerges.
{"title":"Propagation of the Madden-Julian oscillation as a deterministic chaotic phenomenon","authors":"Daisuke Takasuka, Tamaki Suematsu, Hiroaki Miura, Masuo Nakano","doi":"10.1126/sciadv.adz1916","DOIUrl":"https://doi.org/10.1126/sciadv.adz1916","url":null,"abstract":"The Madden-Julian oscillation (MJO) is a planetary-scale tropical weather disturbance marked by eastward-propagating cumulus cloud clusters over the Indo-Pacific region, causing severe weather and climate events worldwide. The mechanism and predictability of MJO propagation remain elusive, partly because relevant multiscale processes are poorly understood. Here, we reveal chaotic MJO propagation arising from cross-scale nonlinear interactions, based on 4000-member ensemble simulations of two MJO events with a global cloud-system–resolving model. Against conventional linear thinking, multiple regimes with distinct timings of MJO propagation emerge under a single atmosphere-ocean background. The emergence of regime bifurcation depends critically on the equatorial asymmetry of climatological sea surface temperature. Selection of the bifurcated regimes is probabilistic, influenced by whether tropical-extratropical interplay promotes moistening associated with westward-propagating tropical waves over the western Pacific. These results contribute to a more complete MJO conceptual model and help foresee when coherent MJO propagation emerges.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"110 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146210434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Giselle Ventura, Masaki Kajimoto, Mossab Saeed, J. Scott Malloy, Ian McGinty, Lyubomyr Bohuta, Kevin A. Charette, Kyle Bilodeau, Gianna Dafflisio, Shannen B. Kizilski, Peter E. Hammer, John P. Carney, David W. Sutherland Jr., Baturalp Arslan, Daniel F. King, David J. Carter, Sitaram M. Emani, Michael A. Portman, Corin Williams
Congenital heart valve defects often require surgical intervention for survival. Now, there are no valve prosthetics on the market that are designed for babies and toddlers who grow rapidly. Recent advancements in expandable valves hold promise for these young patients but currently require invasive balloon catheter procedures for device expansion. Here, we describe the design and preclinical feasibility of a pediatric heart valve stent that spontaneously adapts to growth via a springlike mechanism imparted by the superelastic properties of nitinol. Studies in piglets demonstrated appropriate constraint of the device to small diameters (8 to 9 millimeters) upon implantation, acute valve function, and the ability of the stent to proportionately expand with growth up to 13 millimeters after 6 weeks without subsequent interventions after implantation. We expect that the growth-adaptive stent concept could be broadly leveraged to eliminate surgeries and invasive procedures as young patients grow.
{"title":"Design and preclinical feasibility of a pediatric heart valve stent that spontaneously adapts to growth via a spring mechanism","authors":"Giselle Ventura, Masaki Kajimoto, Mossab Saeed, J. Scott Malloy, Ian McGinty, Lyubomyr Bohuta, Kevin A. Charette, Kyle Bilodeau, Gianna Dafflisio, Shannen B. Kizilski, Peter E. Hammer, John P. Carney, David W. Sutherland Jr., Baturalp Arslan, Daniel F. King, David J. Carter, Sitaram M. Emani, Michael A. Portman, Corin Williams","doi":"","DOIUrl":"","url":null,"abstract":"<div >Congenital heart valve defects often require surgical intervention for survival. Now, there are no valve prosthetics on the market that are designed for babies and toddlers who grow rapidly. Recent advancements in expandable valves hold promise for these young patients but currently require invasive balloon catheter procedures for device expansion. Here, we describe the design and preclinical feasibility of a pediatric heart valve stent that spontaneously adapts to growth via a springlike mechanism imparted by the superelastic properties of nitinol. Studies in piglets demonstrated appropriate constraint of the device to small diameters (8 to 9 millimeters) upon implantation, acute valve function, and the ability of the stent to proportionately expand with growth up to 13 millimeters after 6 weeks without subsequent interventions after implantation. We expect that the growth-adaptive stent concept could be broadly leveraged to eliminate surgeries and invasive procedures as young patients grow.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"12 8","pages":""},"PeriodicalIF":12.5,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146211401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Soon Hyeong So, Sunwoo Kim, Minsu Kim, Donghyun Kim, Taehwan Kim, Kiwon Eum, Yun Ho Kim, Junghwan Kim, Dae Woo Kim
We report the application of mixed-matrix membranes for high-temperature hydrogen separation. To enhance hydrogen selectivity, graphene nanoribbons (GNRs) were incorporated into ZIF-8 fillers, forming a physically confined structure conducive to hydrogen transport. The metal-organic framework (MOF)/GNR filler embedded into a polyimide (PI) matrix yielded a much higher H2 permeability (298 Barrer, +40%) and H2/N2 selectivity (15, +25%) than the neat PI membrane. In particular, the as-prepared asymmetric membrane achieved a H2 permeance of 212 ± 45 Gas Permeation Unit (GPU) and H2/N2 selectivity of 19 ± 2 at 35°C. Remarkably, at 300°C, the H2 permeance rose to 775 ± 139 GPU while maintaining a H2/N2 selectivity of 13 ± 1, outperforming polymer-based membranes. A techno-economic analysis of an NH3 cracking process demonstrated that this high permeance reduces membrane area requirements by 68.2% and lowers H2 separation costs by 35.1% compared with operation at 35°C, leading to a 9.8% reduction in the levelized cost of hydrogen.
本文报道了混合基质膜在高温氢分离中的应用。为了提高氢的选择性，将石墨烯纳米带（gnr）加入到ZIF-8填料中，形成有利于氢传输的物理受限结构。将金属有机骨架(MOF)/GNR填料嵌入聚酰亚胺（PI）基质中，其H2渗透率（298 Barrer, +40%）和H2/N2选择性（15,+25%）明显高于纯PI膜。特别是，制备的不对称膜在35℃时H2渗透率为212±45 Gas permeability Unit (GPU)， H2/N2选择性为19±2。值得注意的是，在300°C时，H2透过率上升到775±139 GPU，同时保持了13±1的H2/N2选择性，优于聚合物基膜。对NH3裂解工艺的技术经济分析表明，与在35℃下操作相比，这种高透性使膜面积需求减少了68.2%，H2分离成本降低了35.1%，从而使氢气的平准化成本降低了9.8%。
{"title":"Metal-organic framework/graphene nanoribbon/polyimide mixed-matrix membranes for high-temperature H2/N2 separation","authors":"Soon Hyeong So, Sunwoo Kim, Minsu Kim, Donghyun Kim, Taehwan Kim, Kiwon Eum, Yun Ho Kim, Junghwan Kim, Dae Woo Kim","doi":"","DOIUrl":"","url":null,"abstract":"<div >We report the application of mixed-matrix membranes for high-temperature hydrogen separation. To enhance hydrogen selectivity, graphene nanoribbons (GNRs) were incorporated into ZIF-8 fillers, forming a physically confined structure conducive to hydrogen transport. The metal-organic framework (MOF)/GNR filler embedded into a polyimide (PI) matrix yielded a much higher H<sub>2</sub> permeability (298 Barrer, +40%) and H<sub>2</sub>/N<sub>2</sub> selectivity (15, +25%) than the neat PI membrane. In particular, the as-prepared asymmetric membrane achieved a H<sub>2</sub> permeance of 212 ± 45 Gas Permeation Unit (GPU) and H<sub>2</sub>/N<sub>2</sub> selectivity of 19 ± 2 at 35°C. Remarkably, at 300°C, the H<sub>2</sub> permeance rose to 775 ± 139 GPU while maintaining a H<sub>2</sub>/N<sub>2</sub> selectivity of 13 ± 1, outperforming polymer-based membranes. A techno-economic analysis of an NH<sub>3</sub> cracking process demonstrated that this high permeance reduces membrane area requirements by 68.2% and lowers H<sub>2</sub> separation costs by 35.1% compared with operation at 35°C, leading to a 9.8% reduction in the levelized cost of hydrogen.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"12 8","pages":""},"PeriodicalIF":12.5,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146211402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cong Yin, John T. Abatzoglou, Matthew W. Jones, Alison C. Cullen, Mojtaba Sadegh, Juanle Wang, Yangxiaoyue Liu
Concurrent extreme fire weather creates favorable conditions for widespread large fires, which can complicate the coordination of fire suppression resources and degrade regional air quality. Here, we examine the patterns and trends of intra- and interregional synchronous fire weather (SFW) and explore their links to climate variability and air quality impacts. We find climatologically elevated intraregional SFW in boreal regions, as well as interregional synchronicity among northern temperate and boreal regions. Significant increases in SFW occurred during 1979 to 2024, with more than a twofold increase observed in most regions. We estimate that over half of the observed increase is attributable to anthropogenic climate change. Internal modes of climate variability strongly influence SFW in several regions, including Equatorial Asia, which experiences 43 additional intraregional SFW days during El Niño years. Furthermore, SFW is strongly correlated with regional fire-sourced PM2.5 in multiple regions globally. These findings highlight the growing challenges posed by SFW for firefighting coordination and human health.
{"title":"Increasing synchronicity of global extreme fire weather","authors":"Cong Yin, John T. Abatzoglou, Matthew W. Jones, Alison C. Cullen, Mojtaba Sadegh, Juanle Wang, Yangxiaoyue Liu","doi":"","DOIUrl":"","url":null,"abstract":"<div >Concurrent extreme fire weather creates favorable conditions for widespread large fires, which can complicate the coordination of fire suppression resources and degrade regional air quality. Here, we examine the patterns and trends of intra- and interregional synchronous fire weather (SFW) and explore their links to climate variability and air quality impacts. We find climatologically elevated intraregional SFW in boreal regions, as well as interregional synchronicity among northern temperate and boreal regions. Significant increases in SFW occurred during 1979 to 2024, with more than a twofold increase observed in most regions. We estimate that over half of the observed increase is attributable to anthropogenic climate change. Internal modes of climate variability strongly influence SFW in several regions, including Equatorial Asia, which experiences 43 additional intraregional SFW days during El Niño years. Furthermore, SFW is strongly correlated with regional fire-sourced PM<sub>2.5</sub> in multiple regions globally. These findings highlight the growing challenges posed by SFW for firefighting coordination and human health.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"12 8","pages":""},"PeriodicalIF":12.5,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146211408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cong Yin, John T. Abatzoglou, Matthew W. Jones, Alison C. Cullen, Mojtaba Sadegh, Juanle Wang, Yangxiaoyue Liu
Concurrent extreme fire weather creates favorable conditions for widespread large fires, which can complicate the coordination of fire suppression resources and degrade regional air quality. Here, we examine the patterns and trends of intra- and interregional synchronous fire weather (SFW) and explore their links to climate variability and air quality impacts. We find climatologically elevated intraregional SFW in boreal regions, as well as interregional synchronicity among northern temperate and boreal regions. Significant increases in SFW occurred during 1979 to 2024, with more than a twofold increase observed in most regions. We estimate that over half of the observed increase is attributable to anthropogenic climate change. Internal modes of climate variability strongly influence SFW in several regions, including Equatorial Asia, which experiences 43 additional intraregional SFW days during El Niño years. Furthermore, SFW is strongly correlated with regional fire-sourced PM 2.5 in multiple regions globally. These findings highlight the growing challenges posed by SFW for firefighting coordination and human health.
{"title":"Increasing synchronicity of global extreme fire weather","authors":"Cong Yin, John T. Abatzoglou, Matthew W. Jones, Alison C. Cullen, Mojtaba Sadegh, Juanle Wang, Yangxiaoyue Liu","doi":"10.1126/sciadv.adx8813","DOIUrl":"https://doi.org/10.1126/sciadv.adx8813","url":null,"abstract":"Concurrent extreme fire weather creates favorable conditions for widespread large fires, which can complicate the coordination of fire suppression resources and degrade regional air quality. Here, we examine the patterns and trends of intra- and interregional synchronous fire weather (SFW) and explore their links to climate variability and air quality impacts. We find climatologically elevated intraregional SFW in boreal regions, as well as interregional synchronicity among northern temperate and boreal regions. Significant increases in SFW occurred during 1979 to 2024, with more than a twofold increase observed in most regions. We estimate that over half of the observed increase is attributable to anthropogenic climate change. Internal modes of climate variability strongly influence SFW in several regions, including Equatorial Asia, which experiences 43 additional intraregional SFW days during El Niño years. Furthermore, SFW is strongly correlated with regional fire-sourced PM <jats:sub>2.5</jats:sub> in multiple regions globally. These findings highlight the growing challenges posed by SFW for firefighting coordination and human health.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"71 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146210018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Magdalena Machowska, Natalia Szostak, Adrian Tire, Wladyslaw Wegorek, Malwina Suszynska, Arkadiusz Kajdasz, Paulina Galka-Marciniak, Anna Philips, Piotr Kozlowski
A growing number of mutations are being identified in the noncoding genome, including microRNA (miRNA) genes; however, little is known about the consequences of these mutations and how harmful they are to the functioning of miRNA genes. To evaluate the effects of miRNA gene mutations, we took advantage of a large collection of somatic mutations identified in miRNA genes in >10,000 The Cancer Genome Atlas cancer samples and compared them with the corresponding miRNA sequencing data. Using different analytical approaches and rigorous statistical criteria, we revealed that a substantial fraction of mutations is deleterious for the proper functioning of miRNA genes affecting the level of mature miRNAs, isomiR profiles (precision of DROSHA/DICER1 cleavage), and/or 5p/3p miRNA strand balance. We also showed that most mutations, especially those identified as deleterious, destabilize the structure of miRNA precursors. The analysis showed that many miRNA gene mutations can damage miRNA genes and, if located in disease-related miRNA genes, may be pathogenic variants.
{"title":"miRNA gene mutations commonly disrupt the proper functioning of miRNA genes","authors":"Magdalena Machowska, Natalia Szostak, Adrian Tire, Wladyslaw Wegorek, Malwina Suszynska, Arkadiusz Kajdasz, Paulina Galka-Marciniak, Anna Philips, Piotr Kozlowski","doi":"10.1126/sciadv.aea6079","DOIUrl":"https://doi.org/10.1126/sciadv.aea6079","url":null,"abstract":"A growing number of mutations are being identified in the noncoding genome, including microRNA (miRNA) genes; however, little is known about the consequences of these mutations and how harmful they are to the functioning of miRNA genes. To evaluate the effects of miRNA gene mutations, we took advantage of a large collection of somatic mutations identified in miRNA genes in >10,000 The Cancer Genome Atlas cancer samples and compared them with the corresponding miRNA sequencing data. Using different analytical approaches and rigorous statistical criteria, we revealed that a substantial fraction of mutations is deleterious for the proper functioning of miRNA genes affecting the level of mature miRNAs, isomiR profiles (precision of DROSHA/DICER1 cleavage), and/or 5p/3p miRNA strand balance. We also showed that most mutations, especially those identified as deleterious, destabilize the structure of miRNA precursors. The analysis showed that many miRNA gene mutations can damage miRNA genes and, if located in disease-related miRNA genes, may be pathogenic variants.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"55 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146210301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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