Bailey A. Francis, Latasha Ludwig, Chang He, Melanie Dobromylskyj, Christof A. Bertram, Heike Aupperle-Lellbach, Hannah Wong, Aiden P. Foster, Mark J. Arends, Alejandro Suárez-Bonnet, Simon L. Priestnall, Laetitia Tatiersky, Fernanda Castillo-Alcala, Angie Rupp, Arlene Khachadoorian, Eda Parlak, Marine Inglebert, Shevaniee Umamaheswaran, Saamin Cheema, Martin Del Castillo Velasco-Herrera, Kim Wong, Ian C. Vermes, Jamie Billington, Sven Rottenberg, Geoffrey A. Wood, David J. Adams, Louise van der Weyden
Cancer is a common cause of morbidity and mortality in domestic cats. Because the mutational landscape of domestic cat tumors remains uncharacterized, we performed targeted sequencing of 493 feline tumor–normal tissue pairs from 13 tumor types, focusing on the feline orthologs of ~1000 human cancer genes. TP53 was the most frequently mutated gene, and the most recurrent copy number alterations were loss of PTEN or FAS or gain of MYC . By identifying 31 driver genes, mutational signatures, viral sequences, and tumor-predisposing germline variants, our study provides insight into the domestic cat oncogenome. We demonstrate key similarities with the human oncogenome, confirming the cat as a valuable model for comparative studies, and identify potentially actionable mutations, aligning with a “One Medicine” approach.
{"title":"The oncogenome of the domestic cat","authors":"Bailey A. Francis, Latasha Ludwig, Chang He, Melanie Dobromylskyj, Christof A. Bertram, Heike Aupperle-Lellbach, Hannah Wong, Aiden P. Foster, Mark J. Arends, Alejandro Suárez-Bonnet, Simon L. Priestnall, Laetitia Tatiersky, Fernanda Castillo-Alcala, Angie Rupp, Arlene Khachadoorian, Eda Parlak, Marine Inglebert, Shevaniee Umamaheswaran, Saamin Cheema, Martin Del Castillo Velasco-Herrera, Kim Wong, Ian C. Vermes, Jamie Billington, Sven Rottenberg, Geoffrey A. Wood, David J. Adams, Louise van der Weyden","doi":"10.1126/science.ady6651","DOIUrl":"https://doi.org/10.1126/science.ady6651","url":null,"abstract":"Cancer is a common cause of morbidity and mortality in domestic cats. Because the mutational landscape of domestic cat tumors remains uncharacterized, we performed targeted sequencing of 493 feline tumor–normal tissue pairs from 13 tumor types, focusing on the feline orthologs of ~1000 human cancer genes. <jats:italic toggle=\"yes\">TP53</jats:italic> was the most frequently mutated gene, and the most recurrent copy number alterations were loss of <jats:italic toggle=\"yes\">PTEN</jats:italic> or <jats:italic toggle=\"yes\">FAS</jats:italic> or gain of <jats:italic toggle=\"yes\">MYC</jats:italic> . By identifying 31 driver genes, mutational signatures, viral sequences, and tumor-predisposing germline variants, our study provides insight into the domestic cat oncogenome. We demonstrate key similarities with the human oncogenome, confirming the cat as a valuable model for comparative studies, and identify potentially actionable mutations, aligning with a “One Medicine” approach.","PeriodicalId":21678,"journal":{"name":"Science","volume":"49 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146222980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
David A. Hodell, Fátima Abrantes, Carlos A. Alvarez Zarikian, Timothy D. Herbert, Mengyao Du, Simon J. Crowhurst, Maryline Mleneck-Vautravers, James E. Rolfe, Xi Chen, Hannah L. Brooks, William B. Clark, Louise F. B. Dauchy-Tric, Viviane dos Santos Rocha, José-Abel Flores, Sophia K. V. Hines, Huai-Hsuan May Huang, Hisashi Ikeda, Stefanie Kaboth-Bahr, Junichiro Kuroda, Jasmin M. Link, Jerry F. McManus, Bryce A. Mitsunaga, Lucien Nana Yobo, Celeste T. Pallone, Xiaolei Pang, Marion Y. Péral, Emília Salgueiro, Saray Sanchez, Komal Verma, Jiawang Wu, Chuang Xuan, Jimin Yu, Lauren A. Haygood, Diederik Liebrand, Vitor Magalhães, Monserrat Alonso-Garcia, Mónica Duque-Castaño, Fernanda Ferreira, Mafalda Freitas, Lívia Gebara Cordeiro, Isabelle Gil, María González-Martín, Ana Lopes, Cristina Lopes, Vasiliki Margari, Laura Martín-García, Lélia Matos, Aline Mega, Giulia Molina, Filipa Naughton, Dulce Oliveira, Andreia Rebotim, Teresa Rodrigues, André Santana, Raúl Trejos-Tamayo, Polychronis C. Tzedakis
The Quaternary Period (the last 2.58 Ma) was characterized by the waxing and waning of large ice sheets in the Northern Hemisphere. Using sediment sequences from the Iberian Margin, we demonstrate that expansion of Northern Hemisphere ice sheets around 2.7 Ma was accompanied by the emergence of millennial climate variability (MCV) during glacial periods. The onset of MCV at ~2.7 Ma was heralded by isolated precursor events, followed by multiple millennial climate oscillations at ~2.5 Ma. These events coincided with deposition of ice-rafted detritus in the North Atlantic, suggesting a role for marine-terminating ice sheets. Once established, MCV became an intrinsic feature of glacial climates of the Quaternary. Our findings underscore the profound impact Northern Hemisphere glaciation had on climate variability across multiple time scales.
{"title":"Onset of millennial climate variability with the intensification of Northern Hemisphere glaciation","authors":"David A. Hodell, Fátima Abrantes, Carlos A. Alvarez Zarikian, Timothy D. Herbert, Mengyao Du, Simon J. Crowhurst, Maryline Mleneck-Vautravers, James E. Rolfe, Xi Chen, Hannah L. Brooks, William B. Clark, Louise F. B. Dauchy-Tric, Viviane dos Santos Rocha, José-Abel Flores, Sophia K. V. Hines, Huai-Hsuan May Huang, Hisashi Ikeda, Stefanie Kaboth-Bahr, Junichiro Kuroda, Jasmin M. Link, Jerry F. McManus, Bryce A. Mitsunaga, Lucien Nana Yobo, Celeste T. Pallone, Xiaolei Pang, Marion Y. Péral, Emília Salgueiro, Saray Sanchez, Komal Verma, Jiawang Wu, Chuang Xuan, Jimin Yu, Lauren A. Haygood, Diederik Liebrand, Vitor Magalhães, Monserrat Alonso-Garcia, Mónica Duque-Castaño, Fernanda Ferreira, Mafalda Freitas, Lívia Gebara Cordeiro, Isabelle Gil, María González-Martín, Ana Lopes, Cristina Lopes, Vasiliki Margari, Laura Martín-García, Lélia Matos, Aline Mega, Giulia Molina, Filipa Naughton, Dulce Oliveira, Andreia Rebotim, Teresa Rodrigues, André Santana, Raúl Trejos-Tamayo, Polychronis C. Tzedakis","doi":"10.1126/science.ady7970","DOIUrl":"https://doi.org/10.1126/science.ady7970","url":null,"abstract":"The Quaternary Period (the last 2.58 Ma) was characterized by the waxing and waning of large ice sheets in the Northern Hemisphere. Using sediment sequences from the Iberian Margin, we demonstrate that expansion of Northern Hemisphere ice sheets around 2.7 Ma was accompanied by the emergence of millennial climate variability (MCV) during glacial periods. The onset of MCV at ~2.7 Ma was heralded by isolated precursor events, followed by multiple millennial climate oscillations at ~2.5 Ma. These events coincided with deposition of ice-rafted detritus in the North Atlantic, suggesting a role for marine-terminating ice sheets. Once established, MCV became an intrinsic feature of glacial climates of the Quaternary. Our findings underscore the profound impact Northern Hemisphere glaciation had on climate variability across multiple time scales.","PeriodicalId":21678,"journal":{"name":"Science","volume":"6 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146222982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In an era of heightened global competition in science and technology and geopolitical tensions, United States leadership in science has been diminishing. The 2025 Nature Index found that in elite science journals, China accounted for 56% of the publications in 2024, whereas the US contributed only 10%. This is in stark contrast to 5 years earlier when the US still topped the ranking—but China’s surge was becoming apparent. The rapid change indicates that a remodeling of the US science ecosystem is warranted, including the creation of new paths to earning PhDs in science, technology, engineering, and mathematics (STEM) fields, if the United States is to cultivate a much needed, highly skilled scientific workforce.
{"title":"Reimagining STEM doctoral training","authors":"Ian Banks, Prineha Narang","doi":"10.1126/science.aeg3525","DOIUrl":"https://doi.org/10.1126/science.aeg3525","url":null,"abstract":"In an era of heightened global competition in science and technology and geopolitical tensions, United States leadership in science has been diminishing. The 2025 Nature Index found that in elite science journals, China accounted for 56% of the publications in 2024, whereas the US contributed only 10%. This is in stark contrast to 5 years earlier when the US still topped the ranking—but China’s surge was becoming apparent. The rapid change indicates that a remodeling of the US science ecosystem is warranted, including the creation of new paths to earning PhDs in science, technology, engineering, and mathematics (STEM) fields, if the United States is to cultivate a much needed, highly skilled scientific workforce.","PeriodicalId":21678,"journal":{"name":"Science","volume":"128 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146222983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kangkai Liang, Zihao Wang, Weike Quan, Yueqing Shi, Hao Zhou, Liya Bi, Zhiyuan Yin, Nathan Romero, Mark Young, Shaowei Li
Probing vibrations at the single-molecule level is essential for achieving bond-specific chemical control in realistic heterogeneous environments. Here, we introduce a new measurement scheme that integrates frequency-tunable infrared excitation with scanning tunneling microscopy to characterize vibration-mediated nuclear motions of single molecules. We first validated the technique by monitoring the infrared-induced rotation of the ethynyl radical and then applied it to mapping pyrrolidine’s conformational dynamics. The resulting broadband spectra captured fundamental vibrational modes together with rich overtone and combination bands inaccessible by conventional methods, which we confirmed with isotopic substitutions. Density functional theory calculations showed that delocalized modes coupled with pyrrolidine ring puckering drive the structural transition, revealing altered selection rules compared with traditional infrared spectroscopy. This new experimental platform enables molecular vibrations and transformations to be probed with atomic precision.
{"title":"Single-molecule infrared spectroscopy with scanning tunneling microscopy","authors":"Kangkai Liang, Zihao Wang, Weike Quan, Yueqing Shi, Hao Zhou, Liya Bi, Zhiyuan Yin, Nathan Romero, Mark Young, Shaowei Li","doi":"10.1126/science.adz6643","DOIUrl":"https://doi.org/10.1126/science.adz6643","url":null,"abstract":"Probing vibrations at the single-molecule level is essential for achieving bond-specific chemical control in realistic heterogeneous environments. Here, we introduce a new measurement scheme that integrates frequency-tunable infrared excitation with scanning tunneling microscopy to characterize vibration-mediated nuclear motions of single molecules. We first validated the technique by monitoring the infrared-induced rotation of the ethynyl radical and then applied it to mapping pyrrolidine’s conformational dynamics. The resulting broadband spectra captured fundamental vibrational modes together with rich overtone and combination bands inaccessible by conventional methods, which we confirmed with isotopic substitutions. Density functional theory calculations showed that delocalized modes coupled with pyrrolidine ring puckering drive the structural transition, revealing altered selection rules compared with traditional infrared spectroscopy. This new experimental platform enables molecular vibrations and transformations to be probed with atomic precision.","PeriodicalId":21678,"journal":{"name":"Science","volume":"96 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146222984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Researchers identify a complex that hands a mimivirus control of protein synthesis in infected amoebae.
研究人员在受感染的变形虫体内发现了一种复合体，这种复合体使一种微型病毒控制了蛋白质的合成。
{"title":"Giant viruses hijack their hosts' protein factories.","authors":"Catherine Offord","doi":"10.1126/science.aeg5598","DOIUrl":"https://doi.org/10.1126/science.aeg5598","url":null,"abstract":"<p><p>Researchers identify a complex that hands a mimivirus control of protein synthesis in infected amoebae.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":"391 6787","pages":"756"},"PeriodicalIF":45.8,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146228545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yevgeniya Nusinovich, Keith T Smith, Yury V Suleymanov, Di Jiang, Dorothy Hallberg, Stella M Hurtley, Sacha Vignieri, Peter Stern, Mattia Maroso, Angela Hessler, Ekeoma Uzogara, Christiana N Fogg, Wei Wong
Highlights from the Science family of journals.
《科学》系列杂志精选。
{"title":"In Science Journals.","authors":"Yevgeniya Nusinovich, Keith T Smith, Yury V Suleymanov, Di Jiang, Dorothy Hallberg, Stella M Hurtley, Sacha Vignieri, Peter Stern, Mattia Maroso, Angela Hessler, Ekeoma Uzogara, Christiana N Fogg, Wei Wong","doi":"10.1126/science.aeg4775","DOIUrl":"https://doi.org/10.1126/science.aeg4775","url":null,"abstract":"<p><p>Highlights from the <i>Science</i> family of journals.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":"391 6787","pages":"777-779"},"PeriodicalIF":45.8,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146228576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stem cells can be manipulated to form organoids—three-dimensional structures that mimic the vital functions of organs. Organoids are useful for research into developmental, physiological, and pathophysiological mechanisms, and for improving therapies. The ability to monitor and steer organoid maturation in situ, noninvasively, in real time, and over months has the potential to transform biomedical research and regenerative medicine but poses considerable biotechnological challenges (1). On page 786 of this issue, Li et al. (2) report the differentiation of human pluripotent stem cells into pancreatic islet micro-organs containing microelectrodes. These “cyborg pancreatic organoids” enable cell-specific long-term monitoring of islet cell activities, opening new avenues in diabetes research and cell therapy.
{"title":"Cyborg pancreatic islet organoids","authors":"Jochen Lang, Matthieu Raoux","doi":"","DOIUrl":"","url":null,"abstract":"<div >Stem cells can be manipulated to form organoids—three-dimensional structures that mimic the vital functions of organs. Organoids are useful for research into developmental, physiological, and pathophysiological mechanisms, and for improving therapies. The ability to monitor and steer organoid maturation in situ, noninvasively, in real time, and over months has the potential to transform biomedical research and regenerative medicine but poses considerable biotechnological challenges (<i>1</i>). On page 786 of this issue, Li <i>et al.</i> (<i>2</i>) report the differentiation of human pluripotent stem cells into pancreatic islet micro-organs containing microelectrodes. These “cyborg pancreatic organoids” enable cell-specific long-term monitoring of islet cell activities, opening new avenues in diabetes research and cell therapy.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"391 6787","pages":""},"PeriodicalIF":45.8,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146217657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bailey A. Francis, Latasha Ludwig, Chang He, Melanie Dobromylskyj, Christof A. Bertram, Heike Aupperle-Lellbach, Hannah Wong, Aiden P. Foster, Mark J. Arends, Alejandro Suárez-Bonnet, Simon L. Priestnall, Laetitia Tatiersky, Fernanda Castillo-Alcala, Angie Rupp, Arlene Khachadoorian, Eda Parlak, Marine Inglebert, Shevaniee Umamaheswaran, Saamin Cheema, Martin Del Castillo Velasco-Herrera, Kim Wong, Ian C. Vermes, Jamie Billington, Sven Rottenberg, Geoffrey A. Wood, David J. Adams, Louise van der Weyden
Cancer is a common cause of morbidity and mortality in domestic cats. Because the mutational landscape of domestic cat tumors remains uncharacterized, we performed targeted sequencing of 493 feline tumor–normal tissue pairs from 13 tumor types, focusing on the feline orthologs of ~1000 human cancer genes. TP53 was the most frequently mutated gene, and the most recurrent copy number alterations were loss of PTEN or FAS or gain of MYC. By identifying 31 driver genes, mutational signatures, viral sequences, and tumor-predisposing germline variants, our study provides insight into the domestic cat oncogenome. We demonstrate key similarities with the human oncogenome, confirming the cat as a valuable model for comparative studies, and identify potentially actionable mutations, aligning with a “One Medicine” approach.
{"title":"The oncogenome of the domestic cat","authors":"Bailey A. Francis, Latasha Ludwig, Chang He, Melanie Dobromylskyj, Christof A. Bertram, Heike Aupperle-Lellbach, Hannah Wong, Aiden P. Foster, Mark J. Arends, Alejandro Suárez-Bonnet, Simon L. Priestnall, Laetitia Tatiersky, Fernanda Castillo-Alcala, Angie Rupp, Arlene Khachadoorian, Eda Parlak, Marine Inglebert, Shevaniee Umamaheswaran, Saamin Cheema, Martin Del Castillo Velasco-Herrera, Kim Wong, Ian C. Vermes, Jamie Billington, Sven Rottenberg, Geoffrey A. Wood, David J. Adams, Louise van der Weyden","doi":"","DOIUrl":"","url":null,"abstract":"<div >Cancer is a common cause of morbidity and mortality in domestic cats. Because the mutational landscape of domestic cat tumors remains uncharacterized, we performed targeted sequencing of 493 feline tumor–normal tissue pairs from 13 tumor types, focusing on the feline orthologs of ~1000 human cancer genes. <i>TP53</i> was the most frequently mutated gene, and the most recurrent copy number alterations were loss of <i>PTEN</i> or <i>FAS</i> or gain of <i>MYC</i>. By identifying 31 driver genes, mutational signatures, viral sequences, and tumor-predisposing germline variants, our study provides insight into the domestic cat oncogenome. We demonstrate key similarities with the human oncogenome, confirming the cat as a valuable model for comparative studies, and identify potentially actionable mutations, aligning with a “One Medicine” approach.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"391 6787","pages":""},"PeriodicalIF":45.8,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146217677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Protect US fisheries with fair markets","authors":"Martin D. Smith","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"391 6787","pages":""},"PeriodicalIF":45.8,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146217679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The origins of language are not found in the bouba-kiki effect.
语言的起源并没有在bouba-kiki效应中找到。
{"title":"In search of meaning.","authors":"Marcus Perlman, Bodo Winter","doi":"10.1126/science.aee8641","DOIUrl":"https://doi.org/10.1126/science.aee8641","url":null,"abstract":"<p><p>The origins of language are not found in the bouba-kiki effect.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":"391 6787","pages":"762-763"},"PeriodicalIF":45.8,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146228529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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