Pathogenic bacteria belonging to the genus Bordetella infect the upper airways of various mammals and birds and include the whooping cough agent Bordetella pertussis. Bacteria bear proteins on their surface called adhesins that attach to a substratum, other bacteria, or eukaryotic cells. Bordetella express filamentous hemagglutinin (FhaB), an adhesin with a distinct tropism for ciliated epithelial cells that line the respiratory tract. On page 825 of this issue, Costello et al. (1) report that FhaB inserts its C-terminal domain into the cilia of epithelial cells. This allows the domain to latch on to microtubules, the cytoskeletal core of cilia. This fastening enables Bordetella to move down to the cilia base, where it is shielded from being trapped by mucus and swept out of the airways. The mechanism explains the tenacious binding of these bacteria to beating cilia, a distinct feature of B. pertussis virulence.
{"title":"Bacteria gain a firm hold in the airways","authors":"Françoise Jacob-Dubuisson","doi":"","DOIUrl":"","url":null,"abstract":"<div >Pathogenic bacteria belonging to the genus <i>Bordetella</i> infect the upper airways of various mammals and birds and include the whooping cough agent <i>Bordetella pertussis</i>. Bacteria bear proteins on their surface called adhesins that attach to a substratum, other bacteria, or eukaryotic cells. <i>Bordetella</i> express filamentous hemagglutinin (FhaB), an adhesin with a distinct tropism for ciliated epithelial cells that line the respiratory tract. On page 825 of this issue, Costello <i>et al.</i> (<i>1</i>) report that FhaB inserts its C-terminal domain into the cilia of epithelial cells. This allows the domain to latch on to microtubules, the cytoskeletal core of cilia. This fastening enables <i>Bordetella</i> to move down to the cilia base, where it is shielded from being trapped by mucus and swept out of the airways. The mechanism explains the tenacious binding of these bacteria to beating cilia, a distinct feature of <i>B. pertussis</i> virulence.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"391 6787","pages":""},"PeriodicalIF":45.8,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146217661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carlos José Saldanha Machado, Rodrigo Machado Vilani, Philip M. Fearnside
{"title":"Brazil endangers global climate and health","authors":"Carlos José Saldanha Machado, Rodrigo Machado Vilani, Philip M. Fearnside","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"391 6787","pages":""},"PeriodicalIF":45.8,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146217662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ian S. Osborne, Priscilla N. Kelly, Phil Szuromi, Melissa McCartney, Ekeoma Uzogara, Mattia Maroso, L. Bryan Ray
{"title":"In Other Journals","authors":"Ian S. Osborne, Priscilla N. Kelly, Phil Szuromi, Melissa McCartney, Ekeoma Uzogara, Mattia Maroso, L. Bryan Ray","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"391 6787","pages":""},"PeriodicalIF":45.8,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146217673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Michael S. Costello, Bryan Neumann, Mia W. Raimondi, Bonnie J. Cuthbert, Jana Holubová, Fernando Garza-Sánchez, Abdul Samad, Ladislav Bumba, Jacob A. Torres, Nickolas Holznecht, Jessica Mendoza, Ondrej Stanek, Sasiprapa Prombhul, Thomas Weimbs, Meghan A. Morrissey, Diego Acosta-Alvear, David A. Low, Peter Šebo, Celia W. Goulding, Shane Gonen, Christopher S. Hayes
Pathogenic Bordetella bacteria use protein adhesins to infect the ciliated respiratory epithelia of vertebrate hosts. In this work, we show that the filamentous hemagglutinin FhaB adhesin of Bordetella carries a C-terminal microtubule-binding domain (FhaB-CT), which is translocated into host cells to promote colonization. FhaB-CT delivery is required to occupy a niche at the base of cilia in airway epithelia, and mutant bacteria lacking this domain are defective for nasal colonization. These observations suggest that FhaB-CT is transferred into motile respiratory cilia to interact with core axonemal microtubules. We propose that Bordetella adheres initially to the tips of cilia and then deploys multiple FhaB adhesins to migrate to the base of the cilia forest, where the bacteria resist removal by the mucociliary “escalator” that normally clears the respiratory tract of microbes.
{"title":"Bacteria deliver a microtubule-binding protein into mammalian cells to promote colonization","authors":"Michael S. Costello, Bryan Neumann, Mia W. Raimondi, Bonnie J. Cuthbert, Jana Holubová, Fernando Garza-Sánchez, Abdul Samad, Ladislav Bumba, Jacob A. Torres, Nickolas Holznecht, Jessica Mendoza, Ondrej Stanek, Sasiprapa Prombhul, Thomas Weimbs, Meghan A. Morrissey, Diego Acosta-Alvear, David A. Low, Peter Šebo, Celia W. Goulding, Shane Gonen, Christopher S. Hayes","doi":"","DOIUrl":"","url":null,"abstract":"<div >Pathogenic <i>Bordetella</i> bacteria use protein adhesins to infect the ciliated respiratory epithelia of vertebrate hosts. In this work, we show that the filamentous hemagglutinin FhaB adhesin of <i>Bordetella</i> carries a C-terminal microtubule-binding domain (FhaB-CT), which is translocated into host cells to promote colonization. FhaB-CT delivery is required to occupy a niche at the base of cilia in airway epithelia, and mutant bacteria lacking this domain are defective for nasal colonization. These observations suggest that FhaB-CT is transferred into motile respiratory cilia to interact with core axonemal microtubules. We propose that <i>Bordetella</i> adheres initially to the tips of cilia and then deploys multiple FhaB adhesins to migrate to the base of the cilia forest, where the bacteria resist removal by the mucociliary “escalator” that normally clears the respiratory tract of microbes.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"391 6787","pages":""},"PeriodicalIF":45.8,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146217680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yevgeniya Nusinovich, Keith T. Smith, Yury V. Suleymanov, Di Jiang, Dorothy Hallberg, Stella M. Hurtley, Sacha Vignieri, Peter Stern, Mattia Maroso, Angela Hessler, Ekeoma Uzogara, Christiana N. Fogg, Wei Wong
{"title":"In Science Journals","authors":"Yevgeniya Nusinovich, Keith T. Smith, Yury V. Suleymanov, Di Jiang, Dorothy Hallberg, Stella M. Hurtley, Sacha Vignieri, Peter Stern, Mattia Maroso, Angela Hessler, Ekeoma Uzogara, Christiana N. Fogg, Wei Wong","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"391 6787","pages":""},"PeriodicalIF":45.8,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146217670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stem cells can be manipulated to form organoids—three-dimensional structures that mimic the vital functions of organs. Organoids are useful for research into developmental, physiological, and pathophysiological mechanisms, and for improving therapies. The ability to monitor and steer organoid maturation in situ, noninvasively, in real time, and over months has the potential to transform biomedical research and regenerative medicine but poses considerable biotechnological challenges (1). On page 786 of this issue, Li et al. (2) report the differentiation of human pluripotent stem cells into pancreatic islet micro-organs containing microelectrodes. These “cyborg pancreatic organoids” enable cell-specific long-term monitoring of islet cell activities, opening new avenues in diabetes research and cell therapy.
{"title":"Cyborg pancreatic islet organoids","authors":"Jochen Lang, Matthieu Raoux","doi":"","DOIUrl":"","url":null,"abstract":"<div >Stem cells can be manipulated to form organoids—three-dimensional structures that mimic the vital functions of organs. Organoids are useful for research into developmental, physiological, and pathophysiological mechanisms, and for improving therapies. The ability to monitor and steer organoid maturation in situ, noninvasively, in real time, and over months has the potential to transform biomedical research and regenerative medicine but poses considerable biotechnological challenges (<i>1</i>). On page 786 of this issue, Li <i>et al.</i> (<i>2</i>) report the differentiation of human pluripotent stem cells into pancreatic islet micro-organs containing microelectrodes. These “cyborg pancreatic organoids” enable cell-specific long-term monitoring of islet cell activities, opening new avenues in diabetes research and cell therapy.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"391 6787","pages":""},"PeriodicalIF":45.8,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146217657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bailey A. Francis, Latasha Ludwig, Chang He, Melanie Dobromylskyj, Christof A. Bertram, Heike Aupperle-Lellbach, Hannah Wong, Aiden P. Foster, Mark J. Arends, Alejandro Suárez-Bonnet, Simon L. Priestnall, Laetitia Tatiersky, Fernanda Castillo-Alcala, Angie Rupp, Arlene Khachadoorian, Eda Parlak, Marine Inglebert, Shevaniee Umamaheswaran, Saamin Cheema, Martin Del Castillo Velasco-Herrera, Kim Wong, Ian C. Vermes, Jamie Billington, Sven Rottenberg, Geoffrey A. Wood, David J. Adams, Louise van der Weyden
Cancer is a common cause of morbidity and mortality in domestic cats. Because the mutational landscape of domestic cat tumors remains uncharacterized, we performed targeted sequencing of 493 feline tumor–normal tissue pairs from 13 tumor types, focusing on the feline orthologs of ~1000 human cancer genes. TP53 was the most frequently mutated gene, and the most recurrent copy number alterations were loss of PTEN or FAS or gain of MYC. By identifying 31 driver genes, mutational signatures, viral sequences, and tumor-predisposing germline variants, our study provides insight into the domestic cat oncogenome. We demonstrate key similarities with the human oncogenome, confirming the cat as a valuable model for comparative studies, and identify potentially actionable mutations, aligning with a “One Medicine” approach.
{"title":"The oncogenome of the domestic cat","authors":"Bailey A. Francis, Latasha Ludwig, Chang He, Melanie Dobromylskyj, Christof A. Bertram, Heike Aupperle-Lellbach, Hannah Wong, Aiden P. Foster, Mark J. Arends, Alejandro Suárez-Bonnet, Simon L. Priestnall, Laetitia Tatiersky, Fernanda Castillo-Alcala, Angie Rupp, Arlene Khachadoorian, Eda Parlak, Marine Inglebert, Shevaniee Umamaheswaran, Saamin Cheema, Martin Del Castillo Velasco-Herrera, Kim Wong, Ian C. Vermes, Jamie Billington, Sven Rottenberg, Geoffrey A. Wood, David J. Adams, Louise van der Weyden","doi":"","DOIUrl":"","url":null,"abstract":"<div >Cancer is a common cause of morbidity and mortality in domestic cats. Because the mutational landscape of domestic cat tumors remains uncharacterized, we performed targeted sequencing of 493 feline tumor–normal tissue pairs from 13 tumor types, focusing on the feline orthologs of ~1000 human cancer genes. <i>TP53</i> was the most frequently mutated gene, and the most recurrent copy number alterations were loss of <i>PTEN</i> or <i>FAS</i> or gain of <i>MYC</i>. By identifying 31 driver genes, mutational signatures, viral sequences, and tumor-predisposing germline variants, our study provides insight into the domestic cat oncogenome. We demonstrate key similarities with the human oncogenome, confirming the cat as a valuable model for comparative studies, and identify potentially actionable mutations, aligning with a “One Medicine” approach.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"391 6787","pages":""},"PeriodicalIF":45.8,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146217677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Protect US fisheries with fair markets","authors":"Martin D. Smith","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"391 6787","pages":""},"PeriodicalIF":45.8,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146217679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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