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Free speech, fact checking, and the right to accurate information
IF 44.7 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2025-02-06
Stephan Lewandowsky
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引用次数: 0
Does the mantis shrimp pack a phononic shield?
IF 44.7 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2025-02-06
N. A. Alderete, S. Sandeep, S. Raetz, M. Asgari, M. Abi Ghanem, H. D. Espinosa
The powerful strikes generated by the smasher mantis shrimp require it to possess a robust protection mechanism to withstand the resultant forces. Although recent studies have suggested that phononic bandgaps complement the mantis shrimp’s defensive suite, direct experimental evidence for this mechanism has remained elusive. In this work, we explored the phononic properties of the mantis shrimp’s dactyl club using laser ultrasonic techniques and numerical simulations. Our results demonstrate that the dactyl club’s periodic region functions as a dispersive, high-quality graded system, exhibiting Bloch harmonics, flat dispersion branches, ultraslow wave modes, and wide Bragg bandgaps in the lower megahertz range. These features effectively shield the shrimp from harmful high-frequency stress waves generated by cavitation bubble collapse events during impact.
{"title":"Does the mantis shrimp pack a phononic shield?","authors":"N. A. Alderete,&nbsp;S. Sandeep,&nbsp;S. Raetz,&nbsp;M. Asgari,&nbsp;M. Abi Ghanem,&nbsp;H. D. Espinosa","doi":"","DOIUrl":"","url":null,"abstract":"<div >The powerful strikes generated by the smasher mantis shrimp require it to possess a robust protection mechanism to withstand the resultant forces. Although recent studies have suggested that phononic bandgaps complement the mantis shrimp’s defensive suite, direct experimental evidence for this mechanism has remained elusive. In this work, we explored the phononic properties of the mantis shrimp’s dactyl club using laser ultrasonic techniques and numerical simulations. Our results demonstrate that the dactyl club’s periodic region functions as a dispersive, high-quality graded system, exhibiting Bloch harmonics, flat dispersion branches, ultraslow wave modes, and wide Bragg bandgaps in the lower megahertz range. These features effectively shield the shrimp from harmful high-frequency stress waves generated by cavitation bubble collapse events during impact.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"387 6734","pages":""},"PeriodicalIF":44.7,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143253913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances and shortfalls in knowledge of Antarctic terrestrial and freshwater biodiversity
IF 56.9 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2025-02-06 DOI: 10.1126/science.adk2118
L. R. Pertierra, P. Convey, A. Barbosa, E. M. Biersma, D. Cowan, J. A. F. Diniz-Filho, A. de los Ríos, P. Escribano-Álvarez, C. I. Fraser, D. Fontaneto, M. Greve, H. J. Griffiths, M. Harris, K. A. Hughes, H. J. Lynch, R. J. Ladle, X. P. Liu, P. C. le Roux, R. Majewska, M. A. Molina-Montenegro, L. S. Peck, A. Quesada, C. Ronquillo, Y. Ropert-Coudert, L. G. Sancho, A. Terauds, G. Varliero, J. A. Vianna, A. Wilmotte, S. L. Chown, M. Á. Olalla-Tárraga, J. Hortal
Antarctica harbors many distinctive features of life, yet much about the diversity and functioning of Antarctica’s life remains unknown. Evolutionary histories and functional ecology are well understood only for vertebrates, whereas research on invertebrates is largely limited to species descriptions and some studies on environmental tolerances. Knowledge on Antarctic vegetation cover showcases the challenges of characterizing population trends for most groups. Recent community-level microbial studies have provided insights into the functioning of life at its limits. Overall, biotic interactions remain largely unknown across all groups, restricted to basic information on trophic level placement. Insufficient knowledge of many groups limits the understanding of ecological processes on the continent. Remedies for the current situation rely on identifying the caveats of each ecological discipline and finding targeted solutions. Such precise delimitation of knowledge gaps will enable a more aware, representative, and strategic systematic conservation planning of Antarctica.
{"title":"Advances and shortfalls in knowledge of Antarctic terrestrial and freshwater biodiversity","authors":"L. R. Pertierra, P. Convey, A. Barbosa, E. M. Biersma, D. Cowan, J. A. F. Diniz-Filho, A. de los Ríos, P. Escribano-Álvarez, C. I. Fraser, D. Fontaneto, M. Greve, H. J. Griffiths, M. Harris, K. A. Hughes, H. J. Lynch, R. J. Ladle, X. P. Liu, P. C. le Roux, R. Majewska, M. A. Molina-Montenegro, L. S. Peck, A. Quesada, C. Ronquillo, Y. Ropert-Coudert, L. G. Sancho, A. Terauds, G. Varliero, J. A. Vianna, A. Wilmotte, S. L. Chown, M. Á. Olalla-Tárraga, J. Hortal","doi":"10.1126/science.adk2118","DOIUrl":"https://doi.org/10.1126/science.adk2118","url":null,"abstract":"Antarctica harbors many distinctive features of life, yet much about the diversity and functioning of Antarctica’s life remains unknown. Evolutionary histories and functional ecology are well understood only for vertebrates, whereas research on invertebrates is largely limited to species descriptions and some studies on environmental tolerances. Knowledge on Antarctic vegetation cover showcases the challenges of characterizing population trends for most groups. Recent community-level microbial studies have provided insights into the functioning of life at its limits. Overall, biotic interactions remain largely unknown across all groups, restricted to basic information on trophic level placement. Insufficient knowledge of many groups limits the understanding of ecological processes on the continent. Remedies for the current situation rely on identifying the caveats of each ecological discipline and finding targeted solutions. Such precise delimitation of knowledge gaps will enable a more aware, representative, and strategic systematic conservation planning of Antarctica.","PeriodicalId":21678,"journal":{"name":"Science","volume":"12 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143192440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Silene latifolia genome and its giant Y chromosome
IF 56.9 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2025-02-06 DOI: 10.1126/science.adj7430
Carol Moraga, Catarina Branco, Quentin Rougemont, Pavel Jedlička, Eddy Mendoza-Galindo, Paris Veltsos, Melissa Hanique, Ricardo C. Rodríguez de la Vega, Eric Tannier, Xiaodong Liu, Claire Lemaitre, Peter D. Fields, Corinne Cruaud, Karine Labadie, Caroline Belser, Jerome Briolay, Sylvain Santoni, Radim Cegan, Raquel Linheiro, Gabriele Adam, Adil El Filali, Vinciane Mossion, Adnane Boualem, Raquel Tavares, Amine Chebbi, Richard Cordaux, Cécile Fruchard, Djivan Prentout, Amandine Velt, Bruno Spataro, Stephane Delmotte, Laura Weingartner, Helena Toegelová, Zuzana Tulpová, Petr Cápal, Hana Šimková, Helena Štorchová, Manuela Krüger, Oushadee A. J. Abeyawardana, Douglas R. Taylor, Matthew S. Olson, Daniel B. Sloan, Sophie Karrenberg, Lynda F. Delph, Deborah Charlesworth, Aline Muyle, Tatiana Giraud, Abdelhafid Bendahmane, Alex Di Genova, Mohammed-Amin Madoui, Roman Hobza, Gabriel A. B. Marais
In many species with sex chromosomes, the Y is a tiny chromosome. However, the dioecious plant Silene latifolia has a giant ~550-megabase Y chromosome, which has remained unsequenced so far. We used a long- and short-read hybrid approach to obtain a high-quality male genome. Comparative analysis of the sex chromosomes with their homologs in outgroups showed that the Y is highly rearranged and degenerated. Recombination suppression between X and Y extended in several steps and triggered a massive accumulation of repeats on the Y as well as in the nonrecombining pericentromeric region of the X, leading to giant sex chromosomes. Using sex phenotype mutants, we identified candidate sex-determining genes on the Y in locations consistent with their favoring recombination suppression events 11 and 5 million years ago.
{"title":"The Silene latifolia genome and its giant Y chromosome","authors":"Carol Moraga, Catarina Branco, Quentin Rougemont, Pavel Jedlička, Eddy Mendoza-Galindo, Paris Veltsos, Melissa Hanique, Ricardo C. Rodríguez de la Vega, Eric Tannier, Xiaodong Liu, Claire Lemaitre, Peter D. Fields, Corinne Cruaud, Karine Labadie, Caroline Belser, Jerome Briolay, Sylvain Santoni, Radim Cegan, Raquel Linheiro, Gabriele Adam, Adil El Filali, Vinciane Mossion, Adnane Boualem, Raquel Tavares, Amine Chebbi, Richard Cordaux, Cécile Fruchard, Djivan Prentout, Amandine Velt, Bruno Spataro, Stephane Delmotte, Laura Weingartner, Helena Toegelová, Zuzana Tulpová, Petr Cápal, Hana Šimková, Helena Štorchová, Manuela Krüger, Oushadee A. J. Abeyawardana, Douglas R. Taylor, Matthew S. Olson, Daniel B. Sloan, Sophie Karrenberg, Lynda F. Delph, Deborah Charlesworth, Aline Muyle, Tatiana Giraud, Abdelhafid Bendahmane, Alex Di Genova, Mohammed-Amin Madoui, Roman Hobza, Gabriel A. B. Marais","doi":"10.1126/science.adj7430","DOIUrl":"https://doi.org/10.1126/science.adj7430","url":null,"abstract":"In many species with sex chromosomes, the Y is a tiny chromosome. However, the dioecious plant <jats:italic>Silene latifolia</jats:italic> has a giant ~550-megabase Y chromosome, which has remained unsequenced so far. We used a long- and short-read hybrid approach to obtain a high-quality male genome. Comparative analysis of the sex chromosomes with their homologs in outgroups showed that the Y is highly rearranged and degenerated. Recombination suppression between X and Y extended in several steps and triggered a massive accumulation of repeats on the Y as well as in the nonrecombining pericentromeric region of the X, leading to giant sex chromosomes. Using sex phenotype mutants, we identified candidate sex-determining genes on the Y in locations consistent with their favoring recombination suppression events 11 and 5 million years ago.","PeriodicalId":21678,"journal":{"name":"Science","volume":"62 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143192471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hidden cascades of seismic ice stream deformation
IF 56.9 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2025-02-06 DOI: 10.1126/science.adp8094
Andreas Fichtner, Coen Hofstede, Brian L. N. Kennett, Anders Svensson, Julien Westhoff, Fabian Walter, Jean-Paul Ampuero, Eliza Cook, Dimitri Zigone, Daniela Jansen, Olaf Eisen
Ice streams are major regulators of sea level change. However, standard viscous flow simulations of their evolution have limited predictive power due to incomplete understanding of involved processes. On the Greenland ice sheet, borehole fiber-optic observations reveal a brittle deformation mode that is incompatible with viscous flow over length scales similar to the resolution of modern ice sheet models: englacial ice quake cascades that are unobservable at the surface. Nucleating near volcanism-related impurities that promote grain boundary cracking, they appear as a macroscopic form of crystal-scale wild plasticity. A conservative estimate indicates that seismic cascades are likely to produce strain rates that are comparable in amplitude to those measured geodetically, thereby providing a plausible missing link between current ice sheet models and observations.
{"title":"Hidden cascades of seismic ice stream deformation","authors":"Andreas Fichtner, Coen Hofstede, Brian L. N. Kennett, Anders Svensson, Julien Westhoff, Fabian Walter, Jean-Paul Ampuero, Eliza Cook, Dimitri Zigone, Daniela Jansen, Olaf Eisen","doi":"10.1126/science.adp8094","DOIUrl":"https://doi.org/10.1126/science.adp8094","url":null,"abstract":"Ice streams are major regulators of sea level change. However, standard viscous flow simulations of their evolution have limited predictive power due to incomplete understanding of involved processes. On the Greenland ice sheet, borehole fiber-optic observations reveal a brittle deformation mode that is incompatible with viscous flow over length scales similar to the resolution of modern ice sheet models: englacial ice quake cascades that are unobservable at the surface. Nucleating near volcanism-related impurities that promote grain boundary cracking, they appear as a macroscopic form of crystal-scale wild plasticity. A conservative estimate indicates that seismic cascades are likely to produce strain rates that are comparable in amplitude to those measured geodetically, thereby providing a plausible missing link between current ice sheet models and observations.","PeriodicalId":21678,"journal":{"name":"Science","volume":"123 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143192475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New complexity emerges in Earth’s ‘boring’ middle region
IF 44.7 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2025-02-06
Paul Voosen
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引用次数: 0
In Other Journals
IF 44.7 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2025-02-06
Corinne Simonti, Marc S. Lavine, Yevgeniya Nusinovich, Peter Stern, Ekeoma Uzogara, Sumin Jin, Jake S. Yeston
{"title":"In Other Journals","authors":"Corinne Simonti,&nbsp;Marc S. Lavine,&nbsp;Yevgeniya Nusinovich,&nbsp;Peter Stern,&nbsp;Ekeoma Uzogara,&nbsp;Sumin Jin,&nbsp;Jake S. Yeston","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"387 6734","pages":""},"PeriodicalIF":44.7,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/science.adw4663","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143253926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protein codes promote selective subcellular compartmentalization
IF 56.9 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2025-02-06 DOI: 10.1126/science.adq2634
Henry R. Kilgore, Itamar Chinn, Peter G. Mikhael, Ilan Mitnikov, Catherine Van Dongen, Guy Zylberberg, Lena Afeyan, Salman F. Banani, Susana Wilson-Hawken, Tong Ihn Lee, Regina Barzilay, Richard A. Young
Cells have evolved mechanisms to distribute ~10 billion protein molecules to subcellular compartments where diverse proteins involved in shared functions must assemble. Here, we demonstrate that proteins with shared functions share amino acid sequence codes that guide them to compartment destinations. A protein language model, ProtGPS, was developed that predicts with high performance the compartment localization of human proteins excluded from the training set. ProtGPS successfully guided generation of novel protein sequences that selectively assemble in the nucleolus. ProtGPS identified pathological mutations that change this code and lead to altered subcellular localization of proteins. Our results indicate that protein sequences contain not only a folding code, but also a previously unrecognized code governing their distribution to diverse subcellular compartments.
{"title":"Protein codes promote selective subcellular compartmentalization","authors":"Henry R. Kilgore, Itamar Chinn, Peter G. Mikhael, Ilan Mitnikov, Catherine Van Dongen, Guy Zylberberg, Lena Afeyan, Salman F. Banani, Susana Wilson-Hawken, Tong Ihn Lee, Regina Barzilay, Richard A. Young","doi":"10.1126/science.adq2634","DOIUrl":"https://doi.org/10.1126/science.adq2634","url":null,"abstract":"Cells have evolved mechanisms to distribute ~10 billion protein molecules to subcellular compartments where diverse proteins involved in shared functions must assemble. Here, we demonstrate that proteins with shared functions share amino acid sequence codes that guide them to compartment destinations. A protein language model, ProtGPS, was developed that predicts with high performance the compartment localization of human proteins excluded from the training set. ProtGPS successfully guided generation of novel protein sequences that selectively assemble in the nucleolus. ProtGPS identified pathological mutations that change this code and lead to altered subcellular localization of proteins. Our results indicate that protein sequences contain not only a folding code, but also a previously unrecognized code governing their distribution to diverse subcellular compartments.","PeriodicalId":21678,"journal":{"name":"Science","volume":"10 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143192474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Four-dimensional conserved topological charge vectors in plasmonic quasicrystals
IF 56.9 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2025-02-06 DOI: 10.1126/science.adt2495
Shai Tsesses, Pascal Dreher, David Janoschka, Alexander Neuhaus, Kobi Cohen, Tim C. Meiler, Tomer Bucher, Shay Sapir, Bettina Frank, Timothy J. Davis, Frank Meyer zu Heringdorf, Harald Giessen, Guy Bartal
According to Noether’s theorem, symmetries in a physical system are intertwined with conserved quantities. These symmetries often determine the system topology, which is made ever more complex with increased dimensionality. Quasicrystals have neither translational nor global rotational symmetry, yet they intrinsically inhabit a higher-dimensional space in which symmetry resurfaces. Here, we discovered topological charge vectors in four dimensions (4D) that govern the real-space topology of 2D quasicrystals and reveal their inherent conservation laws. We demonstrate control over the topology in pentagonal plasmonic quasilattices, mapped by both phase-resolved and time-domain near-field microscopy, showing that their temporal evolution continuously tunes the 2D projections of their distinct 4D topologies. Our work provides a route to experimentally probe the thermodynamic properties of quasicrystals and topological physics in 4D and above.
{"title":"Four-dimensional conserved topological charge vectors in plasmonic quasicrystals","authors":"Shai Tsesses, Pascal Dreher, David Janoschka, Alexander Neuhaus, Kobi Cohen, Tim C. Meiler, Tomer Bucher, Shay Sapir, Bettina Frank, Timothy J. Davis, Frank Meyer zu Heringdorf, Harald Giessen, Guy Bartal","doi":"10.1126/science.adt2495","DOIUrl":"https://doi.org/10.1126/science.adt2495","url":null,"abstract":"According to Noether’s theorem, symmetries in a physical system are intertwined with conserved quantities. These symmetries often determine the system topology, which is made ever more complex with increased dimensionality. Quasicrystals have neither translational nor global rotational symmetry, yet they intrinsically inhabit a higher-dimensional space in which symmetry resurfaces. Here, we discovered topological charge vectors in four dimensions (4D) that govern the real-space topology of 2D quasicrystals and reveal their inherent conservation laws. We demonstrate control over the topology in pentagonal plasmonic quasilattices, mapped by both phase-resolved and time-domain near-field microscopy, showing that their temporal evolution continuously tunes the 2D projections of their distinct 4D topologies. Our work provides a route to experimentally probe the thermodynamic properties of quasicrystals and topological physics in 4D and above.","PeriodicalId":21678,"journal":{"name":"Science","volume":"38 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143192483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endothelial insulin resistance induced by adrenomedullin mediates obesity-associated diabetes
IF 44.7 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2025-02-06
Haaglim Cho, Chien-Cheng Lai, Rémy Bonnavion, Mohamad Wessam Alnouri, ShengPeng Wang, Kenneth Anthony Roquid, Haruya Kawase, Diana Campos, Min Chen, Lee S. Weinstein, Alfredo Martínez, Mario Looso, Miloslav Sanda, Stefan Offermanns
Insulin resistance is a hallmark of obesity-associated type 2 diabetes. Insulin’s actions go beyond metabolic cells and also involve blood vessels, where insulin increases capillary blood flow and delivery of insulin and nutrients. We show that adrenomedullin, whose plasma levels are increased in obese humans and mice, inhibited insulin signaling in human endothelial cells through protein-tyrosine phosphatase 1B–mediated dephosphorylation of the insulin receptor. In obese mice lacking the endothelial adrenomedullin receptor, insulin-induced endothelial nitric oxide–synthase activation and skeletal muscle perfusion were increased. Treating mice with adrenomedullin mimicked the effect of obesity and induced endothelial and systemic insulin resistance. Endothelial loss or blockade of the adrenomedullin receptor improved obesity-induced insulin resistance. These findings identify a mechanism underlying obesity-induced systemic insulin resistance and suggest approaches to treat obesity-associated type 2 diabetes.
{"title":"Endothelial insulin resistance induced by adrenomedullin mediates obesity-associated diabetes","authors":"Haaglim Cho,&nbsp;Chien-Cheng Lai,&nbsp;Rémy Bonnavion,&nbsp;Mohamad Wessam Alnouri,&nbsp;ShengPeng Wang,&nbsp;Kenneth Anthony Roquid,&nbsp;Haruya Kawase,&nbsp;Diana Campos,&nbsp;Min Chen,&nbsp;Lee S. Weinstein,&nbsp;Alfredo Martínez,&nbsp;Mario Looso,&nbsp;Miloslav Sanda,&nbsp;Stefan Offermanns","doi":"","DOIUrl":"","url":null,"abstract":"<div >Insulin resistance is a hallmark of obesity-associated type 2 diabetes. Insulin’s actions go beyond metabolic cells and also involve blood vessels, where insulin increases capillary blood flow and delivery of insulin and nutrients. We show that adrenomedullin, whose plasma levels are increased in obese humans and mice, inhibited insulin signaling in human endothelial cells through protein-tyrosine phosphatase 1B–mediated dephosphorylation of the insulin receptor. In obese mice lacking the endothelial adrenomedullin receptor, insulin-induced endothelial nitric oxide–synthase activation and skeletal muscle perfusion were increased. Treating mice with adrenomedullin mimicked the effect of obesity and induced endothelial and systemic insulin resistance. Endothelial loss or blockade of the adrenomedullin receptor improved obesity-induced insulin resistance. These findings identify a mechanism underlying obesity-induced systemic insulin resistance and suggest approaches to treat obesity-associated type 2 diabetes.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"387 6734","pages":""},"PeriodicalIF":44.7,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143253922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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