Almost 40 years ago, the American astronomer, planetary scientist, and science communicator, Carl Sagan, reflected on the role of mass media in science communication. “How much science and technology do you see in the mass media? Every newspaper has a daily astrology column. How many have even a weekly science column?” he asked, lamenting the limited science coverage in newspapers. The world has since advanced to a new technological age in which social media, not just newspapers, increasingly act as sources of news, and science journalism has become a considerable platform in communicating scientific research.
{"title":"Beyond misalignment of science in the news and in schools","authors":"Sibel Erduran","doi":"10.1126/science.adu7468","DOIUrl":"https://doi.org/10.1126/science.adu7468","url":null,"abstract":"Almost 40 years ago, the American astronomer, planetary scientist, and science communicator, Carl Sagan, reflected on the role of mass media in science communication. <jats:ext-link xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"uri\" xlink:href=\"https://www.youtube.com/watch?v=gLOZsTMuars\">“How much science and technology do you see in the mass media? Every newspaper has a daily astrology column. How many have even a weekly science column?”</jats:ext-link> he asked, lamenting the limited science coverage in newspapers. The world has since advanced to a new technological age in which social media, not just newspapers, increasingly act as sources of news, and <jats:ext-link xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"uri\" xlink:href=\"https://oxfordre.com/communication/display/10.1093/acrefore/9780190228613.001.0001/acrefore-9780190228613-e-901?d=%2F10.1093%2Facrefore%2F9780190228613.001.0001%2Facrefore-9780190228613-e-901&p=emailA2tfat.voM0.o\">science journalism</jats:ext-link> has become a considerable platform in communicating scientific research.","PeriodicalId":21678,"journal":{"name":"Science","volume":"38 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142917190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Given the prevalence of nitrogen-containing heterocycles in commercial drugs, selectively incorporating a single nitrogen atom is a promising scaffold hopping approach to enhance chemical diversity in drug discovery libraries. We harness the distinct reactivity of sulfenylnitrenes, which insert a single nitrogen atom to transform readily available pyrroles, indoles, and imidazoles into synthetically challenging pyrimidines, quinazolines, and triazines, respectively. Our additive-free method for skeletal editing employs easily accessible, benchtop-stable sulfenylnitrene precursors over a broad temperature range (−30 to 150°C). This approach is compatible with diverse functional groups, including oxidation-sensitive functionalities such as phenols and thioethers, and has been applied to various natural products, amino acids, and pharmaceuticals. Furthermore, we have conducted mechanistic studies and explored regioselectivity outcomes through density functional theory calculations.
{"title":"Sulfenylnitrene-mediated nitrogen-atom insertion for late-stage skeletal editing of N -heterocycles","authors":"Bidhan Ghosh, Prakash Kafle, Rishav Mukherjee, Randall Welles, Deacon Herndon, Kenneth M. Nicholas, Yihan Shao, Indrajeet Sharma","doi":"10.1126/science.adp0974","DOIUrl":"https://doi.org/10.1126/science.adp0974","url":null,"abstract":"Given the prevalence of nitrogen-containing heterocycles in commercial drugs, selectively incorporating a single nitrogen atom is a promising scaffold hopping approach to enhance chemical diversity in drug discovery libraries. We harness the distinct reactivity of sulfenylnitrenes, which insert a single nitrogen atom to transform readily available pyrroles, indoles, and imidazoles into synthetically challenging pyrimidines, quinazolines, and triazines, respectively. Our additive-free method for skeletal editing employs easily accessible, benchtop-stable sulfenylnitrene precursors over a broad temperature range (−30 to 150°C). This approach is compatible with diverse functional groups, including oxidation-sensitive functionalities such as phenols and thioethers, and has been applied to various natural products, amino acids, and pharmaceuticals. Furthermore, we have conducted mechanistic studies and explored regioselectivity outcomes through density functional theory calculations.","PeriodicalId":21678,"journal":{"name":"Science","volume":"36 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142917192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiaoyu Yang, Jason W. Rocks, Kaiyi Jiang, Andrew J. Walters, Kshitij Rai, Jing Liu, Jason Nguyen, Scott D. Olson, Pankaj Mehta, James J. Collins, Nichole M. Daringer, Caleb J. Bashor
Protein phosphorylation signaling networks have a central role in how cells sense and respond to their environment. We engineered artificial phosphorylation networks in which reversible enzymatic phosphorylation cycles were assembled from modular protein domain parts and wired together to create synthetic phosphorylation circuits in human cells. Our design scheme enabled model-guided tuning of circuit function and the ability to make diverse network connections; synthetic phosphorylation circuits can be coupled to upstream cell surface receptors to enable fast-timescale sensing of extracellular ligands, and downstream connections can regulate gene expression. We engineered cell-based cytokine controllers that dynamically sense and suppress activated T cells. Our work introduces a generalizable approach that allows the design of signaling circuits that enable user-defined sense-and-respond function for diverse biosensing and therapeutic applications.
{"title":"Engineering synthetic phosphorylation signaling networks in human cells","authors":"Xiaoyu Yang, Jason W. Rocks, Kaiyi Jiang, Andrew J. Walters, Kshitij Rai, Jing Liu, Jason Nguyen, Scott D. Olson, Pankaj Mehta, James J. Collins, Nichole M. Daringer, Caleb J. Bashor","doi":"10.1126/science.adm8485","DOIUrl":"https://doi.org/10.1126/science.adm8485","url":null,"abstract":"Protein phosphorylation signaling networks have a central role in how cells sense and respond to their environment. We engineered artificial phosphorylation networks in which reversible enzymatic phosphorylation cycles were assembled from modular protein domain parts and wired together to create synthetic phosphorylation circuits in human cells. Our design scheme enabled model-guided tuning of circuit function and the ability to make diverse network connections; synthetic phosphorylation circuits can be coupled to upstream cell surface receptors to enable fast-timescale sensing of extracellular ligands, and downstream connections can regulate gene expression. We engineered cell-based cytokine controllers that dynamically sense and suppress activated T cells. Our work introduces a generalizable approach that allows the design of signaling circuits that enable user-defined sense-and-respond function for diverse biosensing and therapeutic applications.","PeriodicalId":21678,"journal":{"name":"Science","volume":"27 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142917185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cherrelle Dacon, Re’em Moskovitz, Kristian Swearingen, Lais Da Silva Pereira, Yevel Flores-Garcia, Maya Aleshnick, Sachie Kanatani, Barbara Flynn, Alvaro Molina-Cruz, Kurt Wollenberg, Maria Traver, Payton Kirtley, Lauren Purser, Marlon Dillon, Brian Bonilla, Adriano Franco, Samantha Petros, Jake Kritzberg, Courtney Tucker, Gonzalo Gonzalez Paez, Priya Gupta, Melanie J. Shears, Joseph Pazzi, Joshua M. Edgar, Andy A. Teng, Arnel Belmonte, Kyosuke Oda, Safiatou Doumbo, Ludmila Krymskaya, Jeff Skinner, Shanping Li, Suman Ghosal, Kassoum Kayentao, Aissata Ongoiba, Ashley Vaughan, Joseph J. Campo, Boubacar Traore, Carolina Barillas-Mury, Wathsala Wijayalath, Azza Idris, Peter D. Crompton, Photini Sinnis, Brandon K. Wilder, Fidel Zavala, Robert A. Seder, Ian A. Wilson, Joshua Tan
The most advanced monoclonal antibodies (mAbs) and vaccines against malaria target the central repeat region or closely related sequences within the Plasmodium falciparum circumsporozoite protein (PfCSP). Here, using an antigen-agnostic strategy to investigate human antibody responses to whole sporozoites, we identified a class of mAbs that target a cryptic PfCSP epitope that is only exposed after cleavage and subsequent pyroglutamylation (pGlu) of the newly formed N terminus. This pGlu-CSP epitope is not targeted by current anti-PfCSP mAbs and is not included in the licensed malaria vaccines. MAD21-101, the most potent mAb in this class, confers sterile protection against Pf infection in a human liver–chimeric mouse model. These findings reveal a site of vulnerability on the sporozoite surface that can be targeted by next-generation antimalarial interventions.
{"title":"Protective antibodies target cryptic epitope unmasked by cleavage of malaria sporozoite protein","authors":"Cherrelle Dacon, Re’em Moskovitz, Kristian Swearingen, Lais Da Silva Pereira, Yevel Flores-Garcia, Maya Aleshnick, Sachie Kanatani, Barbara Flynn, Alvaro Molina-Cruz, Kurt Wollenberg, Maria Traver, Payton Kirtley, Lauren Purser, Marlon Dillon, Brian Bonilla, Adriano Franco, Samantha Petros, Jake Kritzberg, Courtney Tucker, Gonzalo Gonzalez Paez, Priya Gupta, Melanie J. Shears, Joseph Pazzi, Joshua M. Edgar, Andy A. Teng, Arnel Belmonte, Kyosuke Oda, Safiatou Doumbo, Ludmila Krymskaya, Jeff Skinner, Shanping Li, Suman Ghosal, Kassoum Kayentao, Aissata Ongoiba, Ashley Vaughan, Joseph J. Campo, Boubacar Traore, Carolina Barillas-Mury, Wathsala Wijayalath, Azza Idris, Peter D. Crompton, Photini Sinnis, Brandon K. Wilder, Fidel Zavala, Robert A. Seder, Ian A. Wilson, Joshua Tan","doi":"10.1126/science.adr0510","DOIUrl":"https://doi.org/10.1126/science.adr0510","url":null,"abstract":"The most advanced monoclonal antibodies (mAbs) and vaccines against malaria target the central repeat region or closely related sequences within the <jats:italic>Plasmodium falciparum</jats:italic> circumsporozoite protein (PfCSP). Here, using an antigen-agnostic strategy to investigate human antibody responses to whole sporozoites, we identified a class of mAbs that target a cryptic PfCSP epitope that is only exposed after cleavage and subsequent pyroglutamylation (pGlu) of the newly formed N terminus. This pGlu-CSP epitope is not targeted by current anti-PfCSP mAbs and is not included in the licensed malaria vaccines. MAD21-101, the most potent mAb in this class, confers sterile protection against <jats:italic>Pf</jats:italic> infection in a human liver–chimeric mouse model. These findings reveal a site of vulnerability on the sporozoite surface that can be targeted by next-generation antimalarial interventions.","PeriodicalId":21678,"journal":{"name":"Science","volume":"203 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142917318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-20Epub Date: 2024-12-19DOI: 10.1126/science.adv3780
Jon Cohen
For the second time in 2 years, a long-overlooked virus poses a global threat. Can it be contained?
{"title":"Congo's mpox crisis.","authors":"Jon Cohen","doi":"10.1126/science.adv3780","DOIUrl":"https://doi.org/10.1126/science.adv3780","url":null,"abstract":"<p><p>For the second time in 2 years, a long-overlooked virus poses a global threat. Can it be contained?</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":"386 6728","pages":"1336-1343"},"PeriodicalIF":44.7,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-20Epub Date: 2024-12-19DOI: 10.1126/science.adv4103
Celina Zhao
U.S. scientists studying forests, whales, and more largely rely on devices made in China.
{"title":"Dismay greets possible ban on Chinese drones.","authors":"Celina Zhao","doi":"10.1126/science.adv4103","DOIUrl":"https://doi.org/10.1126/science.adv4103","url":null,"abstract":"<p><p>U.S. scientists studying forests, whales, and more largely rely on devices made in China.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":"386 6728","pages":"1334"},"PeriodicalIF":44.7,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-20Epub Date: 2024-12-19DOI: 10.1126/science.adv3188
Monisha Madhumita
{"title":"A step back, not a setback.","authors":"Monisha Madhumita","doi":"10.1126/science.adv3188","DOIUrl":"https://doi.org/10.1126/science.adv3188","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"386 6728","pages":"1438"},"PeriodicalIF":44.7,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-20Epub Date: 2024-12-19DOI: 10.1126/science.adv4104
Daniel Clery
Languorous cosmic beats could be generated by magnetic forces between orbiting stars.
{"title":"Mysterious radio pulses traced to dance of stellar dwarfs.","authors":"Daniel Clery","doi":"10.1126/science.adv4104","DOIUrl":"https://doi.org/10.1126/science.adv4104","url":null,"abstract":"<p><p>Languorous cosmic beats could be generated by magnetic forces between orbiting stars.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":"386 6728","pages":"1335"},"PeriodicalIF":44.7,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-20Epub Date: 2024-12-19DOI: 10.1126/science.adv3779
Sacha Vignieri, Jake S Yeston, Sumin Jin, Brad Wible, Ekeoma Uzogara, Madeleine Seale, Stella M Hurtley
Editors' selections from the current scientific literature.
编辑从当前科学文献中精选出来的内容。
{"title":"In Other Journals.","authors":"Sacha Vignieri, Jake S Yeston, Sumin Jin, Brad Wible, Ekeoma Uzogara, Madeleine Seale, Stella M Hurtley","doi":"10.1126/science.adv3779","DOIUrl":"https://doi.org/10.1126/science.adv3779","url":null,"abstract":"<p><p>Editors' selections from the current scientific literature.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":"386 6728","pages":"1360-1361"},"PeriodicalIF":44.7,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-20Epub Date: 2024-12-19DOI: 10.1126/science.adv4101
Frederik Joelving
Shoddy commentaries are a quick and dirty route to higher impact numbers.
低劣的评论是提高影响力的捷径。
{"title":"AI-generated commentaries flood journals, distort metrics.","authors":"Frederik Joelving","doi":"10.1126/science.adv4101","DOIUrl":"https://doi.org/10.1126/science.adv4101","url":null,"abstract":"<p><p>Shoddy commentaries are a quick and dirty route to higher impact numbers.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":"386 6728","pages":"1331-1332"},"PeriodicalIF":44.7,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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