{"title":"Indian knowledge.","authors":"Vaishnavi Chandrashekhar","doi":"10.1126/science.ads8453","DOIUrl":"https://doi.org/10.1126/science.ads8453","url":null,"abstract":"<p><p>To distance its science education systems from centurieslong British colonialism, India is leaning into its history and traditions-but at what cost?</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":null,"pages":null},"PeriodicalIF":44.7,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142140984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Learning from a climate disaster: The catastrophic floods in southern Brazil","authors":"Valério D. Pillar, Gerhard E. Overbeck","doi":"10.1126/science.adr8356","DOIUrl":"10.1126/science.adr8356","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":null,"pages":null},"PeriodicalIF":44.7,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142140985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Joseph F. Welklin, Benjamin R. Sonnenberg, Carrie L. Branch, Virginia K. Heinen, Angela M. Pitera, Lauren M. Benedict, Lauren E. Whitenack, Eli S. Bridge, Vladimir V. Pravosudov
Cognitive abilities are hypothesized to affect survival and life span in nonhuman animals. However, most tests of this hypothesis have relied on interspecific comparisons of indirect measures of cognitive ability, such as brain size. We present direct evidence that individual variation in cognitive abilities is associated with differences in life span in a wild food caching bird. We measured the spatial cognitive abilities and tracked the life span of 227 mountain chickadees (Poecile gambeli) in their natural environment and found that individuals with better spatial learning and memory abilities involved in food caching lived longer. These results confirm that enhanced cognitive abilities can be associated with longer life in wild animals and that selection on cognitive abilities can lead to increased life span.
{"title":"Spatial cognitive ability is associated with longevity in food-caching chickadees","authors":"Joseph F. Welklin, Benjamin R. Sonnenberg, Carrie L. Branch, Virginia K. Heinen, Angela M. Pitera, Lauren M. Benedict, Lauren E. Whitenack, Eli S. Bridge, Vladimir V. Pravosudov","doi":"10.1126/science.adn5633","DOIUrl":"10.1126/science.adn5633","url":null,"abstract":"<div >Cognitive abilities are hypothesized to affect survival and life span in nonhuman animals. However, most tests of this hypothesis have relied on interspecific comparisons of indirect measures of cognitive ability, such as brain size. We present direct evidence that individual variation in cognitive abilities is associated with differences in life span in a wild food caching bird. We measured the spatial cognitive abilities and tracked the life span of 227 mountain chickadees (<i>Poecile gambeli</i>) in their natural environment and found that individuals with better spatial learning and memory abilities involved in food caching lived longer. These results confirm that enhanced cognitive abilities can be associated with longer life in wild animals and that selection on cognitive abilities can lead to increased life span.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":null,"pages":null},"PeriodicalIF":44.7,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142141004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Di Jiang, Mattia Maroso, Priscilla N. Kelly, Keith T. Smith, Phil Szuromi, Yevgeniya Nusinovich, Yury Suleymanov
{"title":"In Other Journals","authors":"Di Jiang, Mattia Maroso, Priscilla N. Kelly, Keith T. Smith, Phil Szuromi, Yevgeniya Nusinovich, Yury Suleymanov","doi":"10.1126/science.ads8452","DOIUrl":"10.1126/science.ads8452","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":null,"pages":null},"PeriodicalIF":44.7,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/science.ads8452","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142152373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Matthew D Park, Jessica Le Berichel, Pauline Hamon, C Matthias Wilk, Meriem Belabed, Nader Yatim, Alexis Saffon, Jesse Boumelha, Chiara Falcomatà, Alexander Tepper, Samarth Hegde, Raphaël Mattiuz, Brian Y Soong, Nelson M LaMarche, Frederika Rentzeperis, Leanna Troncoso, Laszlo Halasz, Clotilde Hennequin, Theodore Chin, Earnest P Chen, Amanda M Reid, Matthew Su, Ashley Reid Cahn, Laura L Koekkoek, Nicholas Venturini, Shira Wood-Isenberg, Darwin D'souza, Rachel Chen, Travis Dawson, Kai Nie, Zhihong Chen, Seunghee Kim-Schulze, Maria Casanova-Acebes, Filip K Swirski, Julian Downward, Nicolas Vabret, Brian D Brown, Thomas U Marron, Miriam Merad
Age is a major risk factor for cancer, but how aging impacts tumor control remains unclear. Here, we establish that aging of the immune system, regardless of the age of the stroma and tumor, drives lung cancer progression. Hematopoietic aging enhances emergency myelopoiesis, resulting in the local accumulation of myeloid progenitor-like cells in lung tumors. These cells are a major source of IL-1⍺ that drives the enhanced myeloid response. The age-associated decline of DNMT3A enhances IL-1⍺ production, and disrupting IL-1R1 signaling early during tumor development normalized myelopoiesis and slowed the growth of lung, colonic, and pancreatic tumors. In human tumors, we identified an enrichment for IL-1⍺-expressing monocyte-derived macrophages linked to age, poorer survival, and recurrence, unraveling how aging promotes cancer and offering actionable therapeutic strategies.
{"title":"Hematopoietic aging promotes cancer by fueling IL-1⍺-driven emergency myelopoiesis.","authors":"Matthew D Park, Jessica Le Berichel, Pauline Hamon, C Matthias Wilk, Meriem Belabed, Nader Yatim, Alexis Saffon, Jesse Boumelha, Chiara Falcomatà, Alexander Tepper, Samarth Hegde, Raphaël Mattiuz, Brian Y Soong, Nelson M LaMarche, Frederika Rentzeperis, Leanna Troncoso, Laszlo Halasz, Clotilde Hennequin, Theodore Chin, Earnest P Chen, Amanda M Reid, Matthew Su, Ashley Reid Cahn, Laura L Koekkoek, Nicholas Venturini, Shira Wood-Isenberg, Darwin D'souza, Rachel Chen, Travis Dawson, Kai Nie, Zhihong Chen, Seunghee Kim-Schulze, Maria Casanova-Acebes, Filip K Swirski, Julian Downward, Nicolas Vabret, Brian D Brown, Thomas U Marron, Miriam Merad","doi":"10.1126/science.adn0327","DOIUrl":"https://doi.org/10.1126/science.adn0327","url":null,"abstract":"<p><p>Age is a major risk factor for cancer, but how aging impacts tumor control remains unclear. Here, we establish that aging of the immune system, regardless of the age of the stroma and tumor, drives lung cancer progression. Hematopoietic aging enhances emergency myelopoiesis, resulting in the local accumulation of myeloid progenitor-like cells in lung tumors. These cells are a major source of IL-1⍺ that drives the enhanced myeloid response. The age-associated decline of DNMT3A enhances IL-1⍺ production, and disrupting IL-1R1 signaling early during tumor development normalized myelopoiesis and slowed the growth of lung, colonic, and pancreatic tumors. In human tumors, we identified an enrichment for IL-1⍺-expressing monocyte-derived macrophages linked to age, poorer survival, and recurrence, unraveling how aging promotes cancer and offering actionable therapeutic strategies.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":null,"pages":null},"PeriodicalIF":44.7,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142140969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maria Luísa Jabbur, Benjamin P. Bratton, Carl Hirschie Johnson
Photoperiodic time measurement is the ability of plants and animals to measure differences in day versus night length (photoperiod) and use that information to anticipate critical seasonal transformations, such as annual temperature cycles. This timekeeping phenomenon triggers adaptive responses in higher organisms, such as gonadal stimulation, flowering, and hibernation. Unexpectedly, we observed this capability in cyanobacteria—unicellular prokaryotes with generation times as short as 5 to 6 hours. Cyanobacteria exposed to short, winter-like days developed enhanced resistance to cold mediated by desaturation of membrane lipids and differential programs of gene transcription, including stress response pathways. As in eukaryotes, this photoperiodic timekeeping required an intact circadian clockwork and developed over multiple cycles of photoperiod. Therefore, photoperiodic timekeeping evolved in much simpler organisms than previously appreciated and enabled genetic responses to stresses that recur seasonally.
{"title":"Bacteria can anticipate the seasons: Photoperiodism in cyanobacteria","authors":"Maria Luísa Jabbur, Benjamin P. Bratton, Carl Hirschie Johnson","doi":"10.1126/science.ado8588","DOIUrl":"10.1126/science.ado8588","url":null,"abstract":"<div >Photoperiodic time measurement is the ability of plants and animals to measure differences in day versus night length (photoperiod) and use that information to anticipate critical seasonal transformations, such as annual temperature cycles. This timekeeping phenomenon triggers adaptive responses in higher organisms, such as gonadal stimulation, flowering, and hibernation. Unexpectedly, we observed this capability in cyanobacteria—unicellular prokaryotes with generation times as short as 5 to 6 hours. Cyanobacteria exposed to short, winter-like days developed enhanced resistance to cold mediated by desaturation of membrane lipids and differential programs of gene transcription, including stress response pathways. As in eukaryotes, this photoperiodic timekeeping required an intact circadian clockwork and developed over multiple cycles of photoperiod. Therefore, photoperiodic timekeeping evolved in much simpler organisms than previously appreciated and enabled genetic responses to stresses that recur seasonally.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":null,"pages":null},"PeriodicalIF":44.7,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142140972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Bryan Ray, Jake S. Yeston, Michael A. Funk, Iyinoluwa Sofowora, Peter Stern, Jelena Stajic, Brandon Berry, Sacha Vignieri, Bianca Lopez, Yevgeniya Nusinovich, Priscilla N. Kelly, Marc S. Lavine, Keith T. Smith, Phil Szuromi, John F. Foley, Christiana N. Fogg
{"title":"In Science Journals","authors":"L. Bryan Ray, Jake S. Yeston, Michael A. Funk, Iyinoluwa Sofowora, Peter Stern, Jelena Stajic, Brandon Berry, Sacha Vignieri, Bianca Lopez, Yevgeniya Nusinovich, Priscilla N. Kelly, Marc S. Lavine, Keith T. Smith, Phil Szuromi, John F. Foley, Christiana N. Fogg","doi":"10.1126/science.ads8451","DOIUrl":"10.1126/science.ads8451","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":null,"pages":null},"PeriodicalIF":44.7,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/science.ads8451","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142140981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The history in our genes","authors":"Philip Ball","doi":"10.1126/science.adr3236","DOIUrl":"10.1126/science.adr3236","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":null,"pages":null},"PeriodicalIF":44.7,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142141007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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