Pathogenic bacteria belonging to the genus Bordetella infect the upper airways of various mammals and birds and include the whooping cough agent Bordetella pertussis. Bacteria bear proteins on their surface called adhesins that attach to a substratum, other bacteria, or eukaryotic cells. Bordetella express filamentous hemagglutinin (FhaB), an adhesin with a distinct tropism for ciliated epithelial cells that line the respiratory tract. On page 825 of this issue, Costello et al. (1) report that FhaB inserts its C-terminal domain into the cilia of epithelial cells. This allows the domain to latch on to microtubules, the cytoskeletal core of cilia. This fastening enables Bordetella to move down to the cilia base, where it is shielded from being trapped by mucus and swept out of the airways. The mechanism explains the tenacious binding of these bacteria to beating cilia, a distinct feature of B. pertussis virulence.
{"title":"Bacteria gain a firm hold in the airways","authors":"Françoise Jacob-Dubuisson","doi":"","DOIUrl":"","url":null,"abstract":"<div >Pathogenic bacteria belonging to the genus <i>Bordetella</i> infect the upper airways of various mammals and birds and include the whooping cough agent <i>Bordetella pertussis</i>. Bacteria bear proteins on their surface called adhesins that attach to a substratum, other bacteria, or eukaryotic cells. <i>Bordetella</i> express filamentous hemagglutinin (FhaB), an adhesin with a distinct tropism for ciliated epithelial cells that line the respiratory tract. On page 825 of this issue, Costello <i>et al.</i> (<i>1</i>) report that FhaB inserts its C-terminal domain into the cilia of epithelial cells. This allows the domain to latch on to microtubules, the cytoskeletal core of cilia. This fastening enables <i>Bordetella</i> to move down to the cilia base, where it is shielded from being trapped by mucus and swept out of the airways. The mechanism explains the tenacious binding of these bacteria to beating cilia, a distinct feature of <i>B. pertussis</i> virulence.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"391 6787","pages":""},"PeriodicalIF":45.8,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146217661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carlos José Saldanha Machado, Rodrigo Machado Vilani, Philip M. Fearnside
{"title":"Brazil endangers global climate and health","authors":"Carlos José Saldanha Machado, Rodrigo Machado Vilani, Philip M. Fearnside","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"391 6787","pages":""},"PeriodicalIF":45.8,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146217662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ian S. Osborne, Priscilla N. Kelly, Phil Szuromi, Melissa McCartney, Ekeoma Uzogara, Mattia Maroso, L. Bryan Ray
{"title":"In Other Journals","authors":"Ian S. Osborne, Priscilla N. Kelly, Phil Szuromi, Melissa McCartney, Ekeoma Uzogara, Mattia Maroso, L. Bryan Ray","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"391 6787","pages":""},"PeriodicalIF":45.8,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146217673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Immune-stimulating cocktail could shield against diverse bacterial and viral infections.
免疫刺激鸡尾酒可以防止多种细菌和病毒感染。
{"title":"Unorthodox 'vaccine' offers broad protection in mice.","authors":"Mitch Leslie","doi":"10.1126/science.aeg5596","DOIUrl":"https://doi.org/10.1126/science.aeg5596","url":null,"abstract":"<p><p>Immune-stimulating cocktail could shield against diverse bacterial and viral infections.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":"391 6787","pages":"753"},"PeriodicalIF":45.8,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146228518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A mysterious influenza strain infects livestock around the world. Scientists worry it could become a threat to humans as well.
一种神秘的流感病毒感染了世界各地的牲畜。科学家担心它也会对人类构成威胁。
{"title":"Deciphering D.","authors":"Jon Cohen","doi":"10.1126/science.aeg4774","DOIUrl":"https://doi.org/10.1126/science.aeg4774","url":null,"abstract":"<p><p>A mysterious influenza strain infects livestock around the world. Scientists worry it could become a threat to humans as well.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":"391 6787","pages":"758-761"},"PeriodicalIF":45.8,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146228548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ian S Osborne, Priscilla N Kelly, Phil Szuromi, Melissa McCartney, Ekeoma Uzogara, Mattia Maroso, L Bryan Ray
Editors' selections from the current scientific literature.
编辑从当前的科学文献中选择。
{"title":"In Other Journals.","authors":"Ian S Osborne, Priscilla N Kelly, Phil Szuromi, Melissa McCartney, Ekeoma Uzogara, Mattia Maroso, L Bryan Ray","doi":"10.1126/science.aeg4776","DOIUrl":"https://doi.org/10.1126/science.aeg4776","url":null,"abstract":"<p><p>Editors' selections from the current scientific literature.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":"391 6787","pages":"778-779"},"PeriodicalIF":45.8,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146228562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Protect US fisheries with fair markets.","authors":"Martin D Smith","doi":"10.1126/science.aef2556","DOIUrl":"https://doi.org/10.1126/science.aef2556","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"391 6787","pages":"775"},"PeriodicalIF":45.8,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146228581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
After devastating ecosystems and livelihoods across South America, the golden mussel fulfills a dire prediction.
在破坏了整个南美洲的生态系统和生计之后，金贻贝实现了一个可怕的预言。
{"title":"Invasive mussel is rapidly spreading in Amazonian rivers.","authors":"Sofia Moutinho","doi":"10.1126/science.aeg5594","DOIUrl":"https://doi.org/10.1126/science.aeg5594","url":null,"abstract":"<p><p>After devastating ecosystems and livelihoods across South America, the golden mussel fulfills a dire prediction.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":"391 6787","pages":"750"},"PeriodicalIF":45.8,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146228593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Paul C. Sereno, Daniel Vidal, Nathan P. Myhrvold, Evan Johnson-Ransom, María Ciudad Real, Stephanie L. Baumgart, Noelia Sánchez Fontela, Todd L. Green, Evan T. Saitta, Boubé Adamou, Lauren L. Bop, Tyler M. Keillor, Erin C. Fitzgerald, Didier B. Dutheil, Robert A. S. Laroche, Alexandre V. Demers-Potvin, Álvaro Simarro, Francesc Gascó-Lluna, Ana Lázaro, Arturo Gamonal, Charles V. Beightol, Vincent Reneleau, Rachel Vautrin, Filippo Bertozzo, Alejandro Granados, Grace Kinney-Broderick, Jordan C. Mallon, Rafael M. Lindoso, Jahandar Ramezani
We describe a close relative of Spinosaurus aegyptiacus , the sail-backed, fish-eating giant from nearshore deposits of northern Africa. Spinosaurus mirabilis sp. nov., discovered in the central Sahara alongside long-necked dinosaurs in a riparian habitat, is distinguished by a scimitar-shaped bony crest projecting far above its skull roof. We discern three discrete phases in spinosaurid evolution. During the first phase with roots in the Jurassic, an elongate fish-snaring skull emerged that soon was modified along divergent paths. During a second Early Cretaceous phase, spinosaurids became the dominant predators in circum-Tethyan habitats. The final phase began just before the Late Cretaceous during the opening of the Atlantic Ocean, when spinosaurines attained maximum body size as shallow water ambush specialists limited geographically to northern Africa and South America.
{"title":"Scimitar-crested Spinosaurus species from the Sahara caps stepwise spinosaurid radiation","authors":"Paul C. Sereno, Daniel Vidal, Nathan P. Myhrvold, Evan Johnson-Ransom, María Ciudad Real, Stephanie L. Baumgart, Noelia Sánchez Fontela, Todd L. Green, Evan T. Saitta, Boubé Adamou, Lauren L. Bop, Tyler M. Keillor, Erin C. Fitzgerald, Didier B. Dutheil, Robert A. S. Laroche, Alexandre V. Demers-Potvin, Álvaro Simarro, Francesc Gascó-Lluna, Ana Lázaro, Arturo Gamonal, Charles V. Beightol, Vincent Reneleau, Rachel Vautrin, Filippo Bertozzo, Alejandro Granados, Grace Kinney-Broderick, Jordan C. Mallon, Rafael M. Lindoso, Jahandar Ramezani","doi":"10.1126/science.adx5486","DOIUrl":"https://doi.org/10.1126/science.adx5486","url":null,"abstract":"We describe a close relative of <jats:italic toggle=\"yes\">Spinosaurus aegyptiacus</jats:italic> , the sail-backed, fish-eating giant from nearshore deposits of northern Africa. <jats:italic toggle=\"yes\">Spinosaurus mirabilis</jats:italic> sp. nov., discovered in the central Sahara alongside long-necked dinosaurs in a riparian habitat, is distinguished by a scimitar-shaped bony crest projecting far above its skull roof. We discern three discrete phases in spinosaurid evolution. During the first phase with roots in the Jurassic, an elongate fish-snaring skull emerged that soon was modified along divergent paths. During a second Early Cretaceous phase, spinosaurids became the dominant predators in circum-Tethyan habitats. The final phase began just before the Late Cretaceous during the opening of the Atlantic Ocean, when spinosaurines attained maximum body size as shallow water ambush specialists limited geographically to northern Africa and South America.","PeriodicalId":21678,"journal":{"name":"Science","volume":"4 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146222787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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