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Multifunctional Triamcinolone Acetonide Microneedle Patches for Atopic Dermatitis Treatment 治疗特应性皮炎的多功能曲安奈德微针贴片
Pub Date : 2024-07-28 DOI: 10.1002/sstr.202400302
Liwan Song, Lu Fan, Qingfei Zhang, Shanshan Huang, Bin Kong, Jian Xiao, Ye Xu
Atopic dermatitis (AD), a chronic and inflammatory skin disease, has brought huge physiological and psychological burdens to patients, which causes wide concerns in society. Herein, a multifunctional microneedle (MN) patch is proposed integrated with a desirable moisturizer and intelligent drug delivery capacity for AD treatment. Such MN patch consists of hyaluronic acid (HA) backing and near-infrared (NIR) responsive tips containing black phosphorous quantum dots (BPQDs), low-melting agarose, polyvinylpyrrolidone (PVP), and triamcinolone acetonide (TA). Among them, the soluble HA serves as a long-term moisturizer for relieving dryness symptoms of AD. By introducing the NIR excitable and photothermal responsive BPQDs into agarose, the state of the composite material can be adjusted intelligently via NIR, thus achieving controllable release of the encapsulated TA in tips. Besides, PVP with enough mechanical strength can help MNs successfully penetrate the thickened skin of AD patients. Based on these advantages, it is demonstrated that the multifunctional MN patch reveals a satisfactory therapeutic effect in the AD model of Balb/c mice. These results indicate the potential values of the proposed MN patch in the treatment of AD skin diseases and other related biomedical fields.
特应性皮炎(AD)是一种慢性炎症性皮肤病,给患者带来了巨大的生理和心理负担,引起了社会的广泛关注。本文提出的多功能微针(MN)贴片集成了理想的保湿剂和智能给药能力,可用于特应性皮炎的治疗。这种微针贴片由透明质酸(HA)衬底和含有黑磷量子点(BPQDs)、低熔琼脂糖、聚乙烯吡咯烷酮(PVP)和曲安奈德(TA)的近红外(NIR)响应尖端组成。其中,可溶性 HA 可作为缓解 AD 干燥症状的长期保湿剂。通过在琼脂糖中引入可激发近红外和光热响应的 BPQDs,可通过近红外智能调节复合材料的状态,从而实现可控地在尖端释放包裹的 TA。此外,具有足够机械强度的 PVP 还能帮助 MNs 成功穿透 AD 患者增厚的皮肤。基于这些优势,多功能 MN 贴片在 Balb/c 小鼠 AD 模型中显示出令人满意的治疗效果。这些结果表明了所提出的多功能 MN 贴片在治疗 AD 皮肤病和其他相关生物医学领域的潜在价值。
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引用次数: 0
(C3N2H5)B3O3F2(OH)2: Realizing Large Birefringence via a Synergistic Effect between Anion F/OH-Ratio Optimization and Cation Activation (C3N2H5)B3O3F2(OH)2:通过阴离子 F/OH 比率优化和阳离子活化之间的协同效应实现大双折射
Pub Date : 2024-07-28 DOI: 10.1002/sstr.202400296
Chenhui Hu, Chunjie Shen, Huan Zhou, Jian Han, Zhihua Yang, Kenneth R. Poeppelmeier, Feng Zhang, Shilie Pan
Borates have emerged as a significant resource for exploring birefringent materials in the UV frequency region. The π-conjugated planar anions, such as the [BO3], [B2O5], and [B3O6] units, exhibiting strong polarizability anisotropy, are traditionally good structural models. Both fluorination and hydroxylation have been proven effective strategies to modulate the optical properties of the planar anions. Controlling the ratio between F and OH is the key to realizing a balanced performance between birefringence and bandgap. Based on a fluorination mechanism proposed recently, a novel hydroxyfluorooxoborate (C3N2H5)B3O3F2(OH)2 with an optimal F/OH ratio of 1/1 is synthesized. During the synthesis, another strategy known as “cation activation” is also employed, which further increases birefringence by introducing active cation units. With its superior performance, this compound exhibits a short UV cutoff edge at 214 nm and a substantial birefringence of 0.205 at 546 nm, surpassing the commercial birefringent crystal α-BBO (0.122@532 nm). The synergy between F/OH-ratio optimization and cation activation offers a practical methodology for developing UV birefringent materials.
硼酸盐已成为探索紫外频率区域双折射材料的重要资源。π共轭平面阴离子,如[BO3]、[B2O5]和[B3O6]单元,表现出很强的偏振各向异性,是传统上很好的结构模型。氟化和羟基化已被证明是调节平面阴离子光学性质的有效策略。控制 F 和 OH 之间的比例是实现双折射和带隙之间性能平衡的关键。根据最近提出的氟化机制,我们合成了一种新型羟氟氧硼酸盐 (C3N2H5)B3O3F2(OH)2,其最佳 F/OH 比例为 1/1。在合成过程中,还采用了另一种称为 "阳离子活化 "的策略,通过引入活性阳离子单元进一步提高了双折射性。该化合物性能优越,在 214 纳米波长处具有较短的紫外截止边,在 546 纳米波长处具有 0.205 的大幅双折射,超过了商用双折射晶体 α-BBO(0.122@532 纳米波长)。F/OH 比率优化和阳离子活化之间的协同作用为开发紫外双折射材料提供了一种实用的方法。
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引用次数: 0
Structural Disorder by Octahedral Tilting in Inorganic Halide Perovskites: New Insight with Bayesian Optimization 无机卤化物包光体中八面体倾斜造成的结构紊乱:贝叶斯优化的新见解
Pub Date : 2024-07-28 DOI: 10.1002/sstr.202400268
Jingrui Li, Fang Pan, Guo-Xu Zhang, Zenghui Liu, Hua Dong, Dawei Wang, Zhuangde Jiang, Wei Ren, Zuo-Guang Ye, Milica Todorović, Patrick Rinke
Structural disorder is common in metal-halide perovskites and important for understanding the functional properties of these materials. First-principles methods can address structure variation on the atomistic scale, but they are often limited by the lack of structure-sampling schemes required to characterize the disorder. Herein, structural disorder in the benchmark inorganic halide perovskites CsPbI3 and CsPbBr3 is computationally studied in terms of the three octahedral-tilting angles. The subsequent variations in energetics and properties are described by 3D potential-energy surfaces (PESs) and property landscapes, delivered by Bayesian optimization as implemented in the Bayesian optimization structure search code sampling density functional theory (DFT) calculations. The rapid convergence of the PES with about 200 DFT data points in 3D searches demonstrates the power of active learning and strategic sampling with Bayesian optimization. Further analysis indicates that disorder grows with increasing temperature and reveals that the material bandgap at finite temperatures is a statistical mean over disordered structures.
结构无序是金属卤化物包晶体中常见的现象,对于了解这些材料的功能特性非常重要。第一原理方法可以解决原子尺度上的结构变化问题,但由于缺乏表征无序所需的结构取样方案,这些方法往往受到限制。在此,我们根据三个八面体倾角对基准无机卤化物包晶石 CsPbI3 和 CsPbBr3 的结构无序性进行了计算研究。随后的能量和性质变化由三维势能面(PES)和性质景观来描述,并通过贝叶斯优化结构搜索代码采样密度泛函理论(DFT)计算来实现。三维搜索中约 200 个 DFT 数据点的 PES 快速收敛表明了贝叶斯优化的主动学习和策略采样的威力。进一步的分析表明,无序度会随着温度的升高而增加,并揭示了有限温度下的材料带隙是无序结构的统计平均值。
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引用次数: 0
One-Pot Synthesis of Conductive Metal–Organic Framework@polypyrrole Hybrids with Enhanced Electromagnetic Wave Absorption Performance 一锅合成具有增强电磁波吸收性能的导电金属有机框架@聚吡咯杂化物
Pub Date : 2024-07-17 DOI: 10.1002/sstr.202400205
Jiale Wu, Kang Wang, Song Ye, Qinglin Zhou, Shengqi Lu, Yuquan Laigao, Lai Jiang, Lanxin Wei, Aming Xie, Haibo Zeng, Weijin Li
Rational heterostructure design can bring interfacial polarization relaxation to significantly enhance the electromagnetic wave (EMW) absorption performance. However, intelligently building a homogeneous heterostructure with superior EMW absorption properties remains a great challenge. Herein, a typical conductive metal–organic framework Cu3(HHTP)2 (hexahydroxytriphenylene, HHTP) is delicately packed onto a polypyrrole (PPy) conductive polymer surface via a one-step in situ polymerization approach. Results show that Cu3(HHTP)2 is well packed on the PPy surface to form an elegant Cu3(HHTP)2@PPy hybrids interfacial microstructure with a unique superiority regarding EMW absorption compared with single components of PPy and Cu3(HHTP)2. Interestingly, the interfacial microstructure of Cu3(HHTP)2@PPy hybrids can be tuned by adjusting the composition of the PPy and Cu3(HHTP)2, resulting in the improvement of impedance matching, conductive loss, and enhancement of interfacial polarization relaxation, endowing the optimization of the EM wave absorption properties of the Cu3(HHTP)2@PPy. The broad effective absorption bandwidth covers a range as broad as 6.68 GHz (11.00–17.68 GHz), which is higher than most reported metal-organic frameworks (MOFs) and conductive polymer-based EM absorbing materials. Herein, new insight for developing highly efficient EMW absorption materials through hybridized interfacial microstructure engineering is provided.
合理的异质结构设计可以带来界面极化弛豫,从而显著提高电磁波(EMW)吸收性能。然而,如何智能地构建具有优异电磁波吸收性能的均相异质结构仍然是一个巨大的挑战。在本文中,通过一步原位聚合法将典型的导电金属有机框架 Cu3(HHTP)2(六羟基三亚苯,HHTP)微妙地填充到聚吡咯(PPy)导电聚合物表面。结果表明,Cu3(HHTP)2 被很好地包裹在 PPy 表面,形成了优雅的 Cu3(HHTP)2@PPy 混合物界面微观结构,与 PPy 和 Cu3(HHTP)2 的单一成分相比,它在电磁波吸收方面具有独特的优越性。有趣的是,Cu3(HHTP)2@PPy 杂化物的界面微结构可以通过调整 PPy 和 Cu3(HHTP)2 的成分来调节,从而改善阻抗匹配、导电损耗和增强界面极化弛豫,优化 Cu3(HHTP)2@PPy 的电磁波吸收特性。其宽广的有效吸收带宽范围可达 6.68 GHz(11.00-17.68 GHz),高于大多数已报道的金属有机框架(MOFs)和导电聚合物基电磁波吸收材料。本文为通过杂化界面微结构工程开发高效电磁波吸收材料提供了新的见解。
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引用次数: 0
Ion-Dependent Stability of DNA Origami Nanostructures in the Presence of Photo-Generated Reactive Oxygen Species DNA 折纸纳米结构在光产生的活性氧作用下的稳定性与离子有关
Pub Date : 2024-07-17 DOI: 10.1002/sstr.202400094
Lukas Rabbe, Jaime Andres Garcia-Diosa, Guido Grundmeier, Adrian Keller
DNA origami nanostructures are promising carries for drug delivery applications. However, their limited stability under relevant conditions often presents a challenge. Herein, the structural stability of DNA origami nanostructures is investigated in a setting compatible with their application in photodynamic therapy (PDT). To this end, DNA origami triangles and six-helix bundles (6HBs) are loaded with the clinically tested photosensitizer methylene blue, which upon irradiation with red light generates reactive oxygen species (ROS) that attack the DNA origami nanostructures. ROS-induced structural damage is observed to depend on the ionic composition of the surrounding medium and becomes more severe at low ionic strength. Mg2+ ions can efficiently protect the DNA origami nanostructures from ROS-induced damage and may even heal some of the damage obtained under Mg2+-free conditions when added after irradiation. Finally, the employed DNA origami 6HBs are more resistant toward ROS-induced structural damage than the triangles, which is attributed to their markedly different mechanical properties. These results thus provide some fundamental insights into the stabilizing role of DNA origami superstructure that may guide the selection or design of DNA origami nanocarriers with optimized stability for their application in PDT.
DNA 折纸纳米结构是很有前途的药物输送应用载体。然而,它们在相关条件下有限的稳定性往往是一个挑战。在此,我们研究了DNA折纸纳米结构在光动力疗法(PDT)应用环境下的结构稳定性。为此,在 DNA 折纸三角形和六螺旋束(6HB)中加入了临床测试过的光敏剂亚甲基蓝,亚甲基蓝在红光照射下会产生活性氧(ROS),攻击 DNA 折纸纳米结构。据观察,ROS 引发的结构破坏取决于周围介质的离子成分,在离子强度较低时破坏更为严重。Mg2+ 离子可以有效地保护 DNA 折纸纳米结构免受 ROS 诱导的破坏,甚至在辐照后加入 Mg2+ 离子还可以修复一些在无 Mg2+ 条件下产生的破坏。最后,所采用的 DNA 折纸 6HB 比三角形更能抵抗 ROS 引起的结构损伤,这归因于它们明显不同的机械性能。因此,这些结果为DNA折纸上层结构的稳定作用提供了一些基本见解,可指导选择或设计具有最佳稳定性的DNA折纸纳米载体,以应用于光导治疗。
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引用次数: 0
Fate of Nanobubbles Generated from CO2–Hydrate Dissociation: Coexistence with Nanodroplets—A Combined Investigation from Experiment and Molecular Dynamics Simulations 二氧化碳-水合物解离产生的纳米气泡的命运:与纳米水滴共存--来自实验和分子动力学模拟的综合研究
Pub Date : 2024-07-17 DOI: 10.1002/sstr.202400080
Mengdi Pan, Parisa Naeiji, Niall J. English
The evolution of CO2 nanobubbles generated by gas–hydrate dissociation is comprehensively studied in this research, employing a synergistic approach that combines laboratory experiments and molecular dynamics simulations. The results show that a higher concentration of nanobubbles can be observed in the early stages of hydrate dissociation, while smaller, thus-generated, nanobubbles are less stable and prefer to amalgamate into larger bubbles through coalescence or Ostwald ripening. From the high Laplace pressure inside some nanobubbles as well as their higher local densities, they may transform into nanodroplets by densification fluctuations. Thus, the dynamic coexistence of nanobubbles and -droplets is confirmed from both experimental and simulation measurements. The number and size of the nanobubbles in the system affects the interaction between water molecules and their movements so that the water molecules diffuse faster upon this condition. The water–water interactions become more pronounced in the presence of nanobubbles and the hydrogen bond network is better preserved in the bulk. This study provides new insights into the microscale mechanisms of gas–hydrate dissociation and highlights the complex interactions between nanobubbles/ -droplets, and the aqueous environment after CO2–hydrate dissociation.
本研究采用实验室实验和分子动力学模拟相结合的协同方法,全面研究了气体-水合物解离产生的二氧化碳纳米气泡的演变过程。结果表明,在水合物解离的早期阶段可以观察到较高浓度的纳米气泡,而由此产生的较小的纳米气泡稳定性较差,更倾向于通过凝聚或奥斯特瓦尔德熟化合并成较大的气泡。一些纳米气泡内部的拉普拉斯压力较高,局部密度也较大,因此可能会通过密度波动转化为纳米液滴。因此,实验和模拟测量都证实了纳米气泡和-液滴的动态共存。系统中纳米气泡的数量和大小会影响水分子之间的相互作用及其运动,从而使水分子在此条件下扩散得更快。在有纳米气泡存在的情况下,水与水之间的相互作用变得更加明显,氢键网络在大体积中得到了更好的保存。这项研究为气水解离的微观机制提供了新的见解,并突出了二氧化碳-水解离后纳米气泡/液滴与水环境之间复杂的相互作用。
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引用次数: 0
Lithicone-Protected Lithium Metal Anodes for Lithium Metal Batteries with Nickel-Rich Cathode Materials 用于含富镍阴极材料的锂金属电池的锂保护金属阳极
Pub Date : 2024-07-17 DOI: 10.1002/sstr.202400174
Ridwan A. Ahmed, Kevin V. Carballo, Krishna P. Koirala, Qian Zhao, Peiyuan Gao, Ju-Myung Kim, Cassidy S. Anderson, Xiangbo Meng, Chongmin Wang, Ji-Guang Zhang, Wu Xu
The high energy density advantage of lithium (Li) metal batteries (LMBs) makes them increasingly desirable; however, problems such as strong reactivity and dendrite growth of Li metal anode limit their practical uses. In this work, a novel Li-containing glycerol (LiGL) or lithicone protection layer on a 50 μm thick Li metal anode is employed for improving the performance of LMBs. This LiGL layer was accurately deposited via a molecular layer deposition (MLD) process at 150 °C, using lithium tert-butoxide and glycerol as precursors. The as-formed LiGL coating layer is highly tunable in its thickness by simply adjusting MLD cycles and shows a good stability and outstanding ionic transport properties. The LiGL layer is found to effectively mitigate side reactions and enhance cycling stability in both symmetric cells and full cells. Specifically, the LMBs with LiGL@Li anode of 400 MLD cycles and LiNi0.6Mn0.2Co0.2O2 cathode enable a capacity retention of ≈87%, much higher than ≈35% of the cells with bare Li after 200 cycles at a charge/discharge current density of 2.1 mA cm−2. This work paves a feasible way for practical LMBs with improved capacity and stability through applying an innovative protection layer on Li metal anodes.
锂(Li)金属电池(LMB)的高能量密度优势使其越来越受到人们的青睐;然而,锂金属负极的强反应性和枝晶生长等问题限制了其实际应用。本研究在 50 μm 厚的锂金属阳极上采用了一种新型含锂甘油(LiGL)或有机硅保护层,以提高锂金属电池的性能。这种 LiGL 层是以叔丁醇锂和甘油为前驱体,通过分子层沉积(MLD)工艺在 150 °C 温度下精确沉积而成的。只需调整分子层沉积(MLD)周期,就能高度调节已形成的锂地胶层厚度,并显示出良好的稳定性和出色的离子传输特性。研究发现,无论是对称电池还是全电池,LiGL 涂层都能有效缓解副反应并提高循环稳定性。具体而言,在充放电电流密度为 2.1 mA cm-2 的条件下,使用 LiGL@Li 阳极和 LiNi0.6Mn0.2Co0.2O2 阴极的 LMB 电池在循环 400 次后,容量保持率可达 ≈87%,远高于使用裸锂电池 200 次后的容量保持率 ≈35%。这项研究通过在锂金属阳极上应用创新保护层,为提高容量和稳定性的实用 LMB 铺平了可行的道路。
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引用次数: 0
Photonic Synthesis and Coating of High‐Entropy Oxide on Layered Ni‐Rich Cathode Particles 层状富镍阴极粒子上高熵氧化物的光子合成与涂层
Pub Date : 2024-07-15 DOI: 10.1002/sstr.202400197
Yanyan Cui, Yushu Tang, Jing Lin, Junbo Wang, Horst Hahn, B. Breitung, Simon Schweidler, T. Brezesinski, M. Botros
High‐entropy materials have drawn much attention as battery materials due to their distinctive properties. Lithiated high‐entropy oxide (Li0.33(MgCoNiCuZn)0.67O, LiHEO) exhibits both high lithium‐ion and electronic conductivity, making it a potential coating material for layered Ni‐rich oxide cathodes (Li1+x(Ni1−y−zCoyMnz)1−xO2, NCM or NMC) in conventional Li‐ion battery cells; however, high‐temperature synthesis limits its application. Therefore, a photonic curing strategy is used for synthesizing LiHEO and the non‐lithiated form (denoted as high‐entropy oxide [HEO]), and nanoscale coatings are successfully produced on LiNi0.85Co0.1Mn0.05O2 (NCM851005) particles. To one's knowledge, this is the first report on particle coating with high‐entropy materials using photonic curing. NCM851005 with LiHEO‐modified surface shows good cycling stability, with a capacity retention of 97% at 1 C rate after 200 cycles. The improvement in electrochemical performance is attributed to the conformal coating that prevents structural changes caused by the reaction between cathode material and liquid electrolyte. Compared to bare NCM851005, the coated material shows a significantly reduced tendency for intergranular cracking, successfully preventing electrolyte penetration and suppressing side reactions. Overall, photonic curing presents a novel cost‐ and energy‐efficient synthesis and coating procedure that paves the way for surface modification of any heat‐sensitive material for a wide range of applications.
高熵材料作为电池材料因其独特的性能而备受关注。锂化高熵氧化物(Li0.33(MgCoNiCuZn)0.67O,LiHEO)具有很高的锂离子电导率和电子电导率,使其成为传统锂离子电池中富镍层状氧化物正极(Li1+x(Ni1-y-zCoyMnz)1-xO2,NCM 或 NMC)的潜在涂层材料;然而,高温合成限制了其应用。因此,我们采用光子固化策略合成 LiHEO 和非石硫酸化形式(称为高熵氧化物 [HEO]),并在 LiNi0.85Co0.1Mn0.05O2 (NCM851005) 颗粒上成功制备出纳米级涂层。据我们所知,这是首次报道利用光子固化技术为粒子涂覆高熵材料。表面经锂氢氧化物修饰的 NCM851005 具有良好的循环稳定性,在 1 C 速率下循环 200 次后容量保持率为 97%。电化学性能的改善归功于保形涂层,它能防止阴极材料和液态电解质之间的反应引起的结构变化。与裸露的 NCM851005 相比,涂层材料明显减少了晶间开裂的趋势,成功地防止了电解质渗透并抑制了副反应。总之,光子固化技术提供了一种新颖的低成本、高能效合成和涂层程序,为广泛应用于任何热敏材料的表面改性铺平了道路。
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引用次数: 0
Quasi-Solid Composite Polymer Electrolyte-Based Structural Batteries with High Ionic Conductivity and Excellent Mechanical Properties 具有高离子电导率和优异机械性能的准固体复合聚合物电解质结构电池
Pub Date : 2024-07-10 DOI: 10.1002/sstr.202400050
Zeru Wang, Yue Hou, Sen Li, Zhuang Xu, Xiaotao Zhu, Bing Guo, Dong Lu, Ke Wang
Structural lithium batteries integrated with energy storage and mechanical load-bearing capabilities hold great promise to revolutionize lightweight transport vehicles. However, the current development of structural batteries faces critical challenges in balancing the electrochemical and mechanical properties of the electrolytes. Herein, a super strong quasi-solid composite polymer electrolyte (QCPE) is successfully fabricated by reinforcing polyelectrolyte with 3D in situ self-assembled metal–organic framework-modified glass fiber (MOF@GF) soaking a small amount of liquid electrolyte, which provides continuous ion conductive pathways for fast Li+ transport and contributes to the high ambient ionic conductivity of 1.47 × 10−3 S cm−1. The micropores and abundant polar functional groups selectively restrict the transport of anions to afford a homogeneous Li+ flux and a high Li+ transference number (0.56). Simultaneously, the MOF@GF provides more effective reinforcement and a remarkably high tensile strength of 48.6 MPa, and Young's modulus of 1.66 GPa is achieved. Furthermore, the lithium metal batteries fabricated with this QCPE exhibit a long, stable operation lifespan of 2000 h and excellent cycling performance with LiFePO4 and NCM811 cathodes. This design strategy generally opens a new avenue for structural batteries with high ionic conductivity and outstanding mechanical properties, which holds great promise for industrial translation.
集成了储能和机械承载能力的结构锂电池为轻型运输车辆带来了巨大的变革前景。然而,目前结构电池的开发在平衡电解质的电化学和机械性能方面面临严峻挑战。本文通过三维原位自组装金属有机框架改性玻璃纤维(MOF@GF)浸泡少量液态电解质来增强聚电解质,成功制备了一种超强准固体复合聚合物电解质(QCPE),为Li+的快速传输提供了连续的离子传导途径,并使其具有1.47 × 10-3 S cm-1的高环境离子电导率。微孔和丰富的极性官能团选择性地限制了阴离子的迁移,从而提供了均匀的 Li+ 通量和较高的 Li+ 迁移数(0.56)。与此同时,MOF@GF 提供了更有效的强化作用,抗拉强度高达 48.6 兆帕,杨氏模量为 1.66 GPa。此外,用这种 QCPE 制成的金属锂电池在使用 LiFePO4 和 NCM811 正极时,具有长达 2000 小时的稳定工作寿命和优异的循环性能。这种设计策略总体上为具有高离子传导性和出色机械性能的结构电池开辟了一条新途径,为工业转化带来了巨大前景。
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引用次数: 0
A Bilingual Nanobiosensor for Cross-Category Integrated Decoding of the Beta-Site Amyloid Precursor Protein-Cleaving Enzyme 1–Aβ Oligomer Signaling Pathway 用于跨类别综合解码β位点淀粉样前体蛋白-切割酶 1-Aβ 寡聚体信号通路的双语纳米生物传感器
Pub Date : 2024-07-10 DOI: 10.1002/sstr.202400241
Tao Cheng, Peifen Lu, Yixi Dong, Jiabao Yu, Gang Wang, Jianwei Jiao, Peng Miao, Jin Jiao
Herein, a sequentially responsive peptide DNA bilingual nanobiosensor is developed, which allows integrated quantification of amyloid signaling pathway. In this system, upstream beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1) protease and downstream Aβ oligomer (AβO) are designed as two inputs for the AND DNA logic gate. In the existence of both inputs, peptide substrate with aptamer can be sequentially cleaved, reporting electrochemical and fluorescence dual-mode outputs. In comparison with conventional single protease activity assay based on peptide nanotechnology, this strategy permits accurate diagnosis of Alzheimer's disease (AD) from normal subjects. More importantly, it can achieve distinguished diagnosis between AD and type 2 diabetes mellitus patients. This bilingual nanobiosensor is successfully applied to detect BACE1 (1–100 U mL−1) and AβO (5–1000 pg mL−1) with limit of detections as low as 0.10 U mL−1 and 0.76 pg mL−1, respectively. Furthermore, this strategy inspires advanced nanobiosensors to target the activation of other signaling pathways, which are potential tools for future biology and medicine investigation.
本文开发了一种顺序响应肽 DNA 双语纳米生物传感器,可对淀粉样蛋白信号通路进行综合定量。在该系统中,上游的β位淀粉样前体蛋白切割酶1(BACE1)蛋白酶和下游的Aβ寡聚体(AβO)被设计为AND DNA逻辑门的两个输入端。在两个输入端同时存在的情况下,带有适配体的多肽底物可以依次被裂解,从而产生电化学和荧光双模式输出。与传统的基于多肽纳米技术的单一蛋白酶活性检测相比,该策略可准确诊断正常人与阿尔茨海默病(AD)。更重要的是,它还能实现对阿尔茨海默病和 2 型糖尿病患者的鉴别诊断。这种双语纳米生物传感器成功应用于检测 BACE1(1-100 U mL-1)和 AβO(5-1000 pg mL-1),检测限分别低至 0.10 U mL-1 和 0.76 pg mL-1。此外,这种策略还启发了针对其他信号通路激活的先进纳米生物传感器,它们是未来生物学和医学研究的潜在工具。
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引用次数: 0
期刊
Small Structures
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