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Alcohol use history predicts antidepressant response to ketamine 酒精使用史预测对氯胺酮的抗抑郁反应
The Brown University Psychopharmacology Update
Pub Date : 2026-01-24 DOI: 10.1002/pu.31412
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引用次数: 0
Meta-analysis finds wide variation in antidepressants' physiological effects 荟萃分析发现抗抑郁药的生理效果差异很大
The Brown University Psychopharmacology Update
Pub Date : 2026-01-24 DOI: 10.1002/pu.31402

A systematic review and network meta-analysis that included 151 studies has found marked differences in individual antidepressants' physiological effects, particularly on cardiometabolic measures. Current treatment guidelines for depression do not reflect these clinically meaningful differences, the investigators stated. Results of the network meta-analysis were published online Oct. 21, 2025 in The Lancet.

一项包括151项研究的系统回顾和网络荟萃分析发现，个体抗抑郁药的生理效果存在显著差异，尤其是在心脏代谢指标上。研究人员指出，目前的抑郁症治疗指南并没有反映出这些有临床意义的差异。网络荟萃分析的结果于2025年10月21日在线发表在《柳叶刀》上。
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引用次数: 0
Your Medication Information 您的用药信息
The Brown University Psychopharmacology Update
Pub Date : 2026-01-24 DOI: 10.1002/pu.31413

Lurasidone (generic) Latuda (brand)

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引用次数: 0
Toward precision psychiatry 走向精准精神病学
The Brown University Psychopharmacology Update
Pub Date : 2025-11-28 DOI: 10.1002/pu.31399
Lawrence H. Price M.D.
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引用次数: 0
Neutropenia associated with xanomeline-trospium 嗜中性粒细胞减少症与黄嘌呤-trospium有关
The Brown University Psychopharmacology Update
Pub Date : 2025-11-28 DOI: 10.1002/pu.31393
Y. W. Francis Lam Pharm.D., FCCP

Xanomeline-trospium (Cobenfy®) is a new antipsychotic with a mechanism of action different from that of currently available typical and atypical antipsychotics. Instead of blocking dopamine D-2 receptors, xanomeline-trospium acts as an agonist at muscarinic M1/M4 receptors, resulting in decreased dopamine release in psychosis-implicated regions of the brain. The trospium component of the combination serves as a selective muscarinic antagonist in the periphery, thereby alleviating xanomeline-mediated cholinergic effects.

Xanomeline-trospium （Cobenfy®）是一种新的抗精神病药物，其作用机制不同于现有的典型和非典型抗精神病药物。xanomeline-trospium不是阻断多巴胺D-2受体，而是作为毒蕈碱M1/M4受体的激动剂，导致大脑中与精神病有关的区域多巴胺释放减少。该组合的trospium成分在外周作为选择性毒蕈碱拮抗剂，从而减轻黄嘌呤介导的胆碱能作用。
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引用次数: 0
Memantine improves social impairment in youths with autism spectrum disorder 美金刚改善自闭症谱系障碍青少年的社交障碍
The Brown University Psychopharmacology Update
Pub Date : 2025-11-28 DOI: 10.1002/pu.31392

Twelve weeks of treatment with memantine resulted in significant improvement in social impairment among youths with autism spectrum disorder, a placebo-controlled trial has found. Memantine also did not result in significantly more adverse events compared with placebo. Study results were published online Oct. 1, 2025, in JAMA Network Open.

一项安慰剂对照试验发现，用美金刚治疗12周后，患有自闭症谱系障碍的青少年的社交障碍得到了显著改善。与安慰剂相比，美金刚组也没有导致更多的不良事件。研究结果于2025年10月1日在线发表在JAMA Network Open上。
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引用次数: 0
Single dose of LSD formulation improves anxiety in Phase 2b trial 单剂量LSD制剂在2b期试验中改善焦虑
The Brown University Psychopharmacology Update
Pub Date : 2025-11-28 DOI: 10.1002/pu.31394

Treatment with a single dose of a pharmaceutical formulation of lysergic acid diethylamide (LSD) resulted in a dose-dependent reduction in anxiety in individuals with generalized anxiety disorder (GAD), a Phase 2b study has found. The two highest of four tested dose strengths of the MM120 formulation demonstrated significant improvement relative to placebo.

一项2b期研究发现，单剂量麦角酸二乙胺（LSD）药物制剂治疗可使广泛性焦虑症（GAD）患者的焦虑呈剂量依赖性减少。MM120配方的四个测试剂量强度中两个最高的剂量强度相对于安慰剂显示出显著的改善。
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引用次数: 0
Polygenic risk for bipolar disorder linked to lithium response in depression treatment 双相情感障碍的多基因风险与抑郁症治疗中的锂反应有关
The Brown University Psychopharmacology Update
Pub Date : 2025-11-28 DOI: 10.1002/pu.31397
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引用次数: 0
Post-approval analysis finds favorable safety for esketamine nasal spray 批准后分析发现艾氯胺酮鼻喷雾剂安全性良好
The Brown University Psychopharmacology Update
Pub Date : 2025-11-28 DOI: 10.1002/pu.31391

Nearly five years of post-approval safety data for esketamine nasal spray have uncovered no new safety concerns associated with the formulation, an analysis has found. Most adverse events occurred during the first treatment session, with incidence decreasing over the course of treatment. Results were published online Sept. 10, 2025, in the American Journal of Psychiatry.

一项分析发现，艾氯胺酮鼻喷雾剂批准后近五年的安全性数据没有发现与该配方相关的新的安全问题。大多数不良事件发生在第一次治疗期间，随着治疗过程发生率逐渐下降。研究结果于2025年9月10日在线发表在《美国精神病学杂志》上。
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引用次数: 0
Solriamfetol improves symptoms in myalgic encephalomyelitis/chronic fatigue 索利氨酚可改善肌痛性脑脊髓炎/慢性疲劳的症状
The Brown University Psychopharmacology Update
Pub Date : 2025-11-28 DOI: 10.1002/pu.31396
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引用次数: 0
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