Olanzapine + fluoxetine (generic) — Symbyax (brand)
Olanzapine + fluoxetine (generic) — Symbyax (brand)
A Phase 3 trial of esmethadone as adjunctive treatment for patients with treatment-resistant depression did not meet its primary endpoint of significant improvement in depressive symptoms at 28 days compared with placebo. Esmethadone did show significant improvement over placebo in treatment response rate.
A population-based cohort study has found that concomitant use of antidepressants and benzodiazepines in the first trimester of pregnancy did not substantially increase risk overall for congenital malformations. Digestive system malformations were the only defects for which a significant risk remained in adjusted analyses. Study results were published online July 2, 2024, in Lancet Psychiatry.
A cohort study based on national data in Denmark has found a dose-dependent association between use of levonorgestrel-releasing intrauterine systems (LNG-IUSs) for contraception and risk of incident depression. The study's investigators pointed out that the 1-year absolute risks of depression in users of LNG-IUSs were relatively small. Study results were published online July 10, 2024 in the American Journal of Psychiatry.
Patients with opioid use disorder (OUD) who exhibited minimal to mild withdrawal at baseline experienced positive outcomes with use of an injectable 7-day formulation of buprenorphine, a nonrandomized trial has found. The study sample of 100 adults reported few serious adverse events and a high degree of satisfaction with the extended-release formulation of buprenorphine.
It is not uncommon for patients with depression to have obesity as a comorbid condition (Mulugeta et al., 2019). Although antidepressants have been implicated in weight gain in patients with depression, the research evidence is conflicting and little data exist for assessing weight changes after more than 12 months of antidepressant therapy.
Sometimes, in the course of perusing the literature for articles that I think warrant coverage in the Update, I come across a worthy study that evokes a sense of déjà vu. When I investigate further, I usually find out that what I'm being reminded of is a study on the same topic from years earlier. Occasionally, it's actually the same study, and I've forgotten that we've already covered it in a previous issue (in the worst of these cases, I don't catch my error — fortunately, nothing gets by our ace managing editor, Gary Enos). Rarely, it's similar to a different study I've seen recently, but one that we didn't cover.
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：