Ziprasidone (generic) Geodon (brand)
Adjusted analyses in a U.S. cohort study found that children exposed in utero to antidepressants were at no higher risk of onset of depression or anxiety than youths whose mothers did not use antidepressants or used the medications in the year before pregnancy. The results suggested that underlying maternal depression is a greater predictor of a childhood depressive diagnosis than antidepressant exposure.
A population-based case series study has found that patients taking gabapentin or pregabalin did not experience an elevated risk of self-harm during treatment. Risk of self-harm was elevated during pre- and post-treatment periods, the investigators found. Study results were published online April 30, 2025 in The BMJ.
The orexin receptor 2-selective agonist oveporexton improved sleep- and wakefulness-related measures in a dose-dependent fashion relative to placebo in adults with narcolepsy type 1, a Phase 2 study has found. Most adverse events associated with oveporexton were mild to moderate, with no reports of suicidality.
Despite clozapine's recognized efficacy for patients with treatment-resistant schizophrenia, most clinicians are aware that it can cause such serious adverse effects as agranulocytosis, seizures, myocarditis, obstipation, and orthostatic hypotension. Less well known are clinical reports and research suggesting an increased risk of pneumonia (Cepaityte et al., 2021). Other than dosage reduction, there has been little guidance on prevention of clozapine-associated pneumonia, or whether clozapine can be reinstated after its resolution.
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