Quetiapine (generic) Seroquel (brand)
A systematic review and meta-analysis encompassing 16 studies has found a non-negligible occurrence of psychosis and bipolar disorder in individuals with attention-deficit hyperactivity disorder (ADHD) who received stimulant treatment. Risk was higher with use of amphetamines compared with methylphenidate.
A systematic review and meta-analysis has found that antipsychotic exposure is associated with significant disruptions to glucose homeostasis, including increased fasting glucose and glycated hemoglobin (HbA1C) relative to placebo. These dysregulations were observed independently of weight gain and treatment duration, the investigators reported. Results of the systematic review and meta-analysis were published online Aug. 27, 2025, in JAMA Psychiatry.
Women with opioid use disorder (OUD) who initiated buprenorphine treatment early in pregnancy discontinued the medication at a higher rate than women who initiated methadone, a cohort study based on public insurance data found. Discontinuation rates for buprenorphine also were higher than those for methadone in the period one year postpartum.
Thirty weeks of treatment with the glucagon-like peptide-1 (GLP-1) receptor agonist semaglutide was more effective than placebo in lowering blood glucose and weight in patients with schizophrenia, prediabetes and obesity, a study has found. Treatment with semaglutide did not worsen psychiatric outcomes in these patients relative to placebo. Study results were published online Sept. 3, 2025, in JAMA Psychiatry.
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