Pregnant women without a severe psychiatric disorder who discontinued use of an antidepressant during pregnancy did not have an increased risk of postpartum psychiatric hospitalization compared with women who continued antidepressant use, a population-based cohort study has found. Those who discontinued use during pregnancy also showed a lower hazard rate for outpatient psychiatric visits after giving birth.
An analysis of longitudinal data with up to 25 years of follow-up has identified five disease categories for which clozapine use was associated with higher risk of adverse drug events. The Finnish study found higher-than-expected prevalence of ileus and pneumonia in patients receiving clozapine, with both illnesses associated with greater mortality.
Inpatients with schizophrenia who switched from antipsychotic polypharmacy to monotherapy experienced significantly reduced side effects, including extrapyramidal symptoms and metabolic effects, an open-label trial has found. The vast majority of patients in the study's switch group stopped taking a first-generation antipsychotic and continued on their second-generation drug. Study results were published online Sept. 16, 2024, in Schizophrenia Research.
Women of menopausal age with schizophrenia or schizoaffective disorder who used menopausal hormone therapy experienced a reduced risk of psychotic relapse compared with non-use, a study using a within-individual design has found. Relapse risk was decreased in women who initiated hormone therapy between the ages of 40 and 55.
A few years ago, I found myself evaluating a clinic patient whose chief complaint was poor concentration, which he maintained was so severe that he could not even hold down a menial job. Fortunately, he was happy to provide me with his diagnosis (“ADHD”) and knew exactly which medication would eliminate his symptoms: amphetamine (I'm using the term broadly here to encompass the numerous pharmaceutical preparations of this drug that are currently available).
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