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Effects of dialyzable leukocyte extracts (DLE) and inosine on stimulated lymphocytes. 可透析白细胞提取物(DLE)和肌苷对受刺激淋巴细胞的影响。
F Komatsu

The effects of dialyzable leukocyte extracts (DLE) on the lymphocytes were examined. The crude DLE suppressed the blast-formation of the PHA-stimulated lymphocytes and proliferation of the leukemic cell-lines but enhanced that of the fibroblastic cells. A certain fraction of the DLE caused the ATP level of the stimulated lymphocytes to rise, after incubation for 24 hours. The fraction was further purified and the inosine eluted from it. The inosine increased the ATP level and markedly enhanced the lymphocyte blast-formation and proliferation of the fibroblastic cells and leukemic cell-lines. It is suggested that when the DLE show some effects on the lymphocytes, the inosine contained in the DLE may show important effects. The effect of inosine was inhibited by other substances contained in the DLE, especially deoxynucleotides. These substances suppressed the blast-formation of the lymphocytes and the proliferation of the leukemic-cell lines. It remains to determine why the fibroblastic cells were not suppressed by them.

观察可透析白细胞提取物(DLE)对淋巴细胞的影响。粗DLE抑制pha刺激淋巴细胞的形成和白血病细胞系的增殖,但增强成纤维细胞的增殖。一定比例的DLE使受刺激淋巴细胞的ATP水平在孵育24小时后升高。进一步纯化该组分,并从中洗脱肌苷。肌苷能提高ATP水平,显著促进成纤维细胞和白血病细胞系淋巴细胞的形成和增殖。提示当DLE对淋巴细胞有一定作用时,其所含肌苷可能发挥重要作用。肌苷的作用被其他物质所抑制,尤其是脱氧核苷酸。这些物质抑制淋巴细胞的形成和白血病细胞系的增殖。为什么成纤维细胞不受它们的抑制还有待确定。
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引用次数: 0
Serum levels of coagulation-fibrinolysis factors in normal pregnancy, labor and puerperium and in cesarean section delivery. 正常妊娠、分娩、产褥期和剖宫产的血凝纤溶因子水平。
A Tei, S Mutoh, Y Yaoi, M Saito

Plasma levels of fibrinopeptide A (FPA), fibrinopeptide B beta 15-42 (FPB beta 15-42), high molecular weight kininogen (HMW-kg), kinin, prekallikrein and kallikrein inhibitor during pregnancy, labor, cesarean section and puerperium were studied in 170 cases of full term normal delivery and 20 cases of cesarean section delivery with 30 non-pregnant women taken as control. Significant increases of FPA, FPB beta 15-42 and kinin during normal delivery and puerperium were found. There was also a significant increase of FPA in the uterine venous blood during cesarean section. Significant decrease of HMW-kg during normal labor and also significant decrease of prekallikrein and kallikrein inhibitor after cesarean section were also seen. Our findings suggested that the hypercoagulable state during pregnancy is due to the increase of thrombin and plasmin activity, and the kallikrein-kinin system may be related to the onset of labor and post-delivery uterine contraction. Increase of the FPA in the uterine blood promoted localised coagulation activity during cesarean section.

本文研究了170例足月正常分娩和20例剖宫产妇女(30例非妊娠妇女为对照)妊娠、分娩、剖宫产及产褥期血浆纤维蛋白肽A (FPA)、纤维蛋白肽B β 15-42 (FPB β 15-42)、高分子量激肽原(hw -kg)、激肽、激肽预激肽及激肽抑制因子水平。正常分娩和产褥期FPA、FPB β 15-42和激肽均显著升高。剖宫产术中子宫静脉血FPA含量明显升高。正常分娩时HMW-kg显著降低,剖宫产后钾化钙素预激肽和钾化钙素抑制剂显著降低。我们的研究结果提示,妊娠期的高凝状态是由于凝血酶和纤溶酶活性的增加,而钾likrein-kinin系统可能与分娩的开始和分娩后子宫收缩有关。剖宫产术中子宫血FPA升高可促进局部凝血活性。
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引用次数: 0
Serum levels of coagulation-fibrinolysis factors in normal pregnancy, labor and puerperium and in cesarean section delivery. 正常妊娠、分娩、产褥期和剖宫产的血凝纤溶因子水平。
Pub Date : 1989-06-01 DOI: 10.11480/BTMD.360202
A. Tei, S. Mutoh, Y. Yaoi, M. Saito
Plasma levels of fibrinopeptide A (FPA), fibrinopeptide B beta 15-42 (FPB beta 15-42), high molecular weight kininogen (HMW-kg), kinin, prekallikrein and kallikrein inhibitor during pregnancy, labor, cesarean section and puerperium were studied in 170 cases of full term normal delivery and 20 cases of cesarean section delivery with 30 non-pregnant women taken as control. Significant increases of FPA, FPB beta 15-42 and kinin during normal delivery and puerperium were found. There was also a significant increase of FPA in the uterine venous blood during cesarean section. Significant decrease of HMW-kg during normal labor and also significant decrease of prekallikrein and kallikrein inhibitor after cesarean section were also seen. Our findings suggested that the hypercoagulable state during pregnancy is due to the increase of thrombin and plasmin activity, and the kallikrein-kinin system may be related to the onset of labor and post-delivery uterine contraction. Increase of the FPA in the uterine blood promoted localised coagulation activity during cesarean section.
本文研究了170例足月正常分娩和20例剖宫产妇女(30例非妊娠妇女为对照)妊娠、分娩、剖宫产及产褥期血浆纤维蛋白肽A (FPA)、纤维蛋白肽B β 15-42 (FPB β 15-42)、高分子量激肽原(hw -kg)、激肽、激肽预激肽及激肽抑制因子水平。正常分娩和产褥期FPA、FPB β 15-42和激肽均显著升高。剖宫产术中子宫静脉血FPA含量明显升高。正常分娩时HMW-kg显著降低,剖宫产后钾化钙素预激肽和钾化钙素抑制剂显著降低。我们的研究结果提示,妊娠期的高凝状态是由于凝血酶和纤溶酶活性的增加,而钾likrein-kinin系统可能与分娩的开始和分娩后子宫收缩有关。剖宫产术中子宫血FPA升高可促进局部凝血活性。
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引用次数: 5
Expression of anti-double stranded DNA idiotype in mixed connective tissue disease and progressive systemic sclerosis. 抗双链DNA独特型在混合性结缔组织病和进行性系统性硬化症中的表达。
T Kubota, Y Kanai

The occurrence of anti-double stranded(ds) DNA idiotype 2C10 was studied in patients with mixed connective tissue disease (MCTD) and progressive systemic sclerosis (PSS). The 2C10-idiotype was originally identified on a dsDNA-specific monoclonal antibody from a lupus-prone MRL/Mp-lpr/lpr (MRL/l) mouse, and it has been demonstrated to be present in the sera of patients with systemic lupus erythematosus (SLE) as well as MRL/l mice. This study showed that three out of ten patients with MCTD and five out of ten with PSS had higher titers of 2C10-idiotype in their sera than the normal subjects. There was a good correlation between the anti-dsDNA activities and the idiotype levels in MCTD (r = 0.85) but not in PSS (r = -0.38). These results suggest that the 2C10-idiotype-bearing antibodies acquire the dsDNA-binding activity more easily in MCTD than in PSS.

研究了混合结缔组织病(MCTD)和进行性系统性硬化症(PSS)患者抗双链(ds) DNA独特型2C10的发生情况。2c10独特型最初是在狼疮易感性MRL/Mp-lpr/lpr (MRL/l)小鼠的dsdna特异性单克隆抗体上鉴定出来的,并且已经证明它存在于系统性红斑狼疮(SLE)患者和MRL/l小鼠的血清中。本研究显示,3 / 10的MCTD患者和5 / 10的PSS患者血清中2c10独特型的滴度高于正常人。MCTD的抗dsdna活性与独特型水平有良好的相关性(r = 0.85),而PSS的抗dsdna活性与独特型水平无相关性(r = -0.38)。这些结果表明,携带2c10独特型的抗体在MCTD中比在PSS中更容易获得dsdna结合活性。
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引用次数: 0
Expression of anti-double stranded DNA idiotype in mixed connective tissue disease and progressive systemic sclerosis. 抗双链DNA独特型在混合性结缔组织病和进行性系统性硬化症中的表达。
Pub Date : 1989-06-01 DOI: 10.11480/BTMD.360201
T. Kubota, Y. Kanai
The occurrence of anti-double stranded(ds) DNA idiotype 2C10 was studied in patients with mixed connective tissue disease (MCTD) and progressive systemic sclerosis (PSS). The 2C10-idiotype was originally identified on a dsDNA-specific monoclonal antibody from a lupus-prone MRL/Mp-lpr/lpr (MRL/l) mouse, and it has been demonstrated to be present in the sera of patients with systemic lupus erythematosus (SLE) as well as MRL/l mice. This study showed that three out of ten patients with MCTD and five out of ten with PSS had higher titers of 2C10-idiotype in their sera than the normal subjects. There was a good correlation between the anti-dsDNA activities and the idiotype levels in MCTD (r = 0.85) but not in PSS (r = -0.38). These results suggest that the 2C10-idiotype-bearing antibodies acquire the dsDNA-binding activity more easily in MCTD than in PSS.
研究了混合结缔组织病(MCTD)和进行性系统性硬化症(PSS)患者抗双链(ds) DNA独特型2C10的发生情况。2c10独特型最初是在狼疮易感性MRL/Mp-lpr/lpr (MRL/l)小鼠的dsdna特异性单克隆抗体上鉴定出来的,并且已经证明它存在于系统性红斑狼疮(SLE)患者和MRL/l小鼠的血清中。本研究显示,3 / 10的MCTD患者和5 / 10的PSS患者血清中2c10独特型的滴度高于正常人。MCTD的抗dsdna活性与独特型水平有良好的相关性(r = 0.85),而PSS的抗dsdna活性与独特型水平无相关性(r = -0.38)。这些结果表明,携带2c10独特型的抗体在MCTD中比在PSS中更容易获得dsdna结合活性。
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引用次数: 1
Effect of porous and dense hydroxyapatite implantation on periodontal tissue regeneration in monkeys. 多孔致密羟基磷灰石植入对猴牙周组织再生的影响。
C J Lin, I Ishikawa

Two different kinds of hydroxyapatite (HA) granules (size: 400-630 microns), 1) porous HA fabricated by the H2O2 bubbling method and 2) dense HA, were placed into the experimentally created, 3-wall, wide periodontal defects in two monkeys to evaluate whether the different structures of hydroxyapatite influence the periodontal response after implantation. Defects without HA implantation served as controls. The HA implant groups showed excellent biocompatibility. Both the porous HA and the dense HA showed a greater amount of "connective tissue attachment or adhesion" than the control group. The amount of the increase by the porous HA group was statistically significant when compared with the control group. However, the three groups showed a similar amount of new cementum formation. These results indicate that the improvement of tissue regeneration by hydroxyapatite implantation was probably due to the prevention of the epithelial downgrowth rather than to the acceleration of the coronal proliferation of the periodontal ligament cells. In the porous HA group, ingrowth of fibrous and osseous tissue in the HA and indefinite tissue-apatite interface were observed. These findings suggest that the porous HA granules formed a firmer attachment to the surrounding periodontal tissue.

将两种不同的羟基磷灰石(HA)颗粒(大小:400-630微米),1)H2O2鼓泡法制备的多孔羟基磷灰石和2)致密羟基磷灰石放置于实验制造的3壁宽牙周缺损中,观察羟基磷灰石不同结构对植入后牙周反应的影响。未植入HA的缺陷作为对照。透明质酸植入组表现出良好的生物相容性。多孔透明质酸和致密透明质酸均表现出比对照组更多的“结缔组织附着或粘连”。与对照组相比,多孔透明质酸组增加的量有统计学意义。然而,这三组显示出相似数量的新牙骨质形成。这些结果表明,羟基磷灰石植入对牙周组织再生的促进作用可能是由于防止了上皮细胞的生长下降,而不是由于加速了牙周膜细胞的冠状增殖。多孔透明质酸组可见纤维组织和骨组织向内生长,组织-磷灰石界面不确定。这些结果表明,多孔透明质酸颗粒与周围牙周组织形成了更牢固的附着。
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引用次数: 0
Clinical application of Hobel's high-risk pregnancy scoring system. Hobel高危妊娠评分系统的临床应用。
A Tei, H Oiyama, S Okawa, M Saito

Hobel's high-risk pregnancy screening scoring system was applied to 1,000 deliveries prospectively to test the validity of the screening system. Our results showed that the incidence of high-risk neonates increased significantly as the risk scores during the prenatal and intrapartum periods increased. In this series, 57.7% of the patients belonged to the low-low risk group and 9.8% was classified as the high-high risk group. The incidence of high-risk neonates in the low-low risk group was 13.5% whereas it was 32.0% in the high-high risk group. Further, maternal hypocapnia during delivery was found to be closely related to the incidence of neonatal hyperbilirubinemia in this series and proper management of maternal ventilations during delivery could reduce the incidence of neonatal hyperbilirubinemia.

Hobel的高危妊娠筛查评分系统应用于1000例分娩,以前瞻性地测试筛查系统的有效性。我们的研究结果显示,随着产前和产时风险评分的增加,高危新生儿的发生率显著增加。57.7%的患者属于低危组,9.8%的患者属于高危组。低-低危组高危新生儿发生率为13.5%,高-高危组为32.0%。此外,本系列研究发现产妇分娩时低碳酸血症与新生儿高胆红素血症的发生率密切相关,分娩时适当的产妇通气管理可以降低新生儿高胆红素血症的发生率。
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引用次数: 0
Percutaneous histopathologic evaluation of liver in treatment of non-Hodgkin's lymphoma. 非霍奇金淋巴瘤治疗中肝脏经皮组织病理学评价。
S Yoshimatsu

The results of 25 percutaneous biopsies of the liver from 24 patients with non-Hodgkin's lymphoma are reported. In all cases, the value of their serum biochemistry (LDH, GOT, GPT and/or alkaline phosphatase) was abnormal and sufficient tissue material was biopsied to obtain a histopathological evaluation. Specimens from five ultrasonically suspected lymphoma of the liver showed tumor involvement histopathologically. Diffuse tumor involvement was also histologically found in three ultrasonically unsuspected livers. Six liver specimens showed degenerative and/or fibrotic change in the new and previously treated patients.

本文报告了24例非霍奇金淋巴瘤患者25例经皮肝脏活检的结果。在所有病例中,他们的血清生化(LDH、GOT、GPT和/或碱性磷酸酶)值均异常,并活检了足够的组织材料以获得组织病理学评估。5例超声怀疑为肝脏淋巴瘤的标本在病理组织学上表现为肿瘤累及。弥漫性肿瘤累及组织学上也发现在三个超声未怀疑的肝脏。六个肝脏标本显示退行性和/或纤维化改变在新的和以前的治疗患者。
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引用次数: 0
Relationship between subjective pain estimation and somatosensory evoked potentials by electrical tooth stimulation. 牙电刺激下主观疼痛估计与体感诱发电位的关系。
M Umino, H Sano, T Ohwatari, S Oka, Y Kubota

The relationship between the amplitude of somatosensory evoked potentials (SEP) and the subjective pain estimation using a visual analogue scale (VAS) was examined in 8 volunteers undergoing randomized electrical tooth stimulation with 3 different intensities. Randomized stimulation was used instead of repetitive stimulation with a fixed intensity in order to minimize the phenomena of habituation and expectancy in recording the SEP and VAS. The VAS scores increased significantly with the stimulus intensity. The amplitude with a latency between 160 and 300 msec (N160-P300) showed a significant increase with the increased intensity. But the amplitudes between 60 and 110 msec (N60-P110) and between 110 and 160 msec (P110-N160) showed no significant change. There was a significant correlation between the amplitude of N160-P300 and the VAS scores. These findings indicate that the component between 160 and 300 msec reflects the perceived pain intensity and the psychological evaluation processes such as cognition, meaning, interpretation and appreciation of pain. The method of randomized stimulation can serve as a simple and useful way for the objective or subjective pain estimation.

采用视觉模拟量表(visual analogue scale, VAS)对8名接受3种不同强度随机牙电刺激的志愿者进行体感诱发电位(SEP)振幅与主观疼痛评估的关系进行了研究。在记录SEP和VAS时,采用随机刺激代替固定强度的重复刺激,以尽量减少习惯化和期望现象。VAS评分随刺激强度的增加而显著升高。潜伏期在160 ~ 300 msec之间(n160 ~ p300)的振幅随强度的增加而显著增加。60 ~ 110 msec (n60 ~ p110)和110 ~ 160 msec (p110 ~ n160)的振幅变化不显著。N160-P300波幅值与VAS评分有显著相关性。这些结果表明,160 ~ 300 msec的分量反映了感知疼痛强度和对疼痛的认知、意义、解释和欣赏等心理评价过程。随机刺激法是一种简单有效的客观或主观疼痛估计方法。
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引用次数: 0
The use of evoked endocardial response for assessment of antiarrhythmic drug effects on myocardium. 应用诱发心内膜反应评价抗心律失常药物对心肌的影响。
Pub Date : 1988-09-01 DOI: 10.11480/BTMD.350302
T. Furukawa, K. Taniguchi, J. Takeuchi
The technique "asymmetric biphasic stimulation" which paces the heart and neutralizes the post-stimulus polarization at the electrode-tissue interface allows for the recording of the entire evoked endocardial response via a single electrode for both pacing and recording. Using this system the effects of antiarrhythmic drugs, procainamide and N-acetylprocainamide, on the myocardium were studied in 20 dogs. Before and during the five-step drug infusion, the evoked endocardial responses were recorded during bipolar and unipolar at the rates of 120, 150 and 200/min. The plasma concentration of the procainamide ranged from 1.7 to 32.5 mg/l and that of N-acetylprocainamide ranged from 8.1 to 116.1 mg/l. Procainamide significantly prolonged both the depolarization duration and the repolarization duration at a low plasma concentration (Class I antiarrhythmic drug property). N-acetylprocainamide significantly prolonged the repolarization duration at a low plasma concentration, while the depolarization duration was not significantly changed at a low or therapeutic plasma concentration (Class III antiarrhythmic drug property). The prolongation of the depolarization duration by procainamide and N-acetylprocainamide was rate-dependent; the faster the rate the greater the prolongation. This simple and accurate assessment of the antiarrhythmic drug effects on the myocardium may provide a future means for the pharmacologic antiarrhythmic therapy.
“非对称双相刺激”技术可以对心脏进行起搏,并在电极-组织界面中和刺激后的极化,从而通过单个电极记录起搏和记录的整个心内膜反应。应用该系统研究了抗心律失常药物普鲁卡因胺和n -乙酰普鲁卡因胺对20只狗心肌的影响。在五步药物输注前和输注过程中,分别以120、150和200/min的速度记录双极和单极期间诱发的心内膜反应。普鲁卡因胺血药浓度范围为1.7 ~ 32.5 mg/l, n -乙酰普鲁卡因胺血药浓度范围为8.1 ~ 116.1 mg/l。普鲁卡因胺在低血浆浓度下显著延长去极化持续时间和复极化持续时间(一类抗心律失常药物性质)。n -乙酰普鲁卡因胺在低血药浓度下显著延长复极化持续时间,而在低血药浓度或治疗性血药浓度下去极化持续时间无显著变化(III类抗心律失常药物性质)。普鲁卡因酰胺和n -乙酰普鲁卡因酰胺对去极化持续时间的延长呈速率依赖性;速度越快,延长的时间就越长。简单准确地评价抗心律失常药物对心肌的作用,为今后的抗心律失常药物治疗提供了一种手段。
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引用次数: 0
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The Bulletin of Tokyo Medical and Dental University
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