Objectives: It is known that insulin resistance increases cardiovardiovascular risk. But it could not obviously be understood whether insulin resistance itself or the metabolic syndrome parameters, like obesity, that already exist in most of them, are responsible for this increased risk. Our aim is to determine cardiovascular risks in obese and non-obese insulin-resistant patients. Methods: One hundred thirty-nine patients were included in the study. They were divided into 4 groups: Group 1 (having obesity and insulin resistance), Group 2 (having only insulin resistance but not obesity), Group 3 (having obesity but not insulin resistance), and Group 4 (having neither obesity nor insulin resistance). Patients having any systemic disease were excluded. Insulin resistance is calculated via Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) formula. Electrocardiographic, echocardiographic and lipid parameters of these patients were compared. Results: High-density lipoprotein (HDL) levels of Group-4 were higher than Group 1 and Group 2. There was no statistical difference in HDL cholesterol levels between Group 3 and the others. Triglyceride and very low-density lipoprotein levels were higher in Group 1. There was no difference in P wave dispersion between the groups. In echocardigraphy, epicardial fat tissue thickness of Group 1 was significantly higher. Prevalance of diastolic dysfunction was higher in Group 1 compared to Group 4. Conclusions: Insulin resistance itself is a risk factor for low HDL levels independent of obesity. When obesity is added to insulin resistance, other cardiovascular risk factors appear, like high triglyceride levels, increase in epicardial fat tissue thickness and presence of diastolic dysfunction. Early detection of insulin resistance may alert us to the risks of cardiovascular diseases.
{"title":"Effects of insulin resistance on cardiovascular risk factors in obese and non-obese patients","authors":"Bahar ARICAN TARIM, Nurdan PAPİLA TOPAL, Özcan Keski̇n, Gokhan Faikoglu, Kubra Saygisever-Faikoglu, Tugce Uskur","doi":"10.18621/eurj.1363228","DOIUrl":"https://doi.org/10.18621/eurj.1363228","url":null,"abstract":"Objectives: It is known that insulin resistance increases cardiovardiovascular risk. But it could not obviously be understood whether insulin resistance itself or the metabolic syndrome parameters, like obesity, that already exist in most of them, are responsible for this increased risk. Our aim is to determine cardiovascular risks in obese and non-obese insulin-resistant patients. Methods: One hundred thirty-nine patients were included in the study. They were divided into 4 groups: Group 1 (having obesity and insulin resistance), Group 2 (having only insulin resistance but not obesity), Group 3 (having obesity but not insulin resistance), and Group 4 (having neither obesity nor insulin resistance). Patients having any systemic disease were excluded. Insulin resistance is calculated via Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) formula. Electrocardiographic, echocardiographic and lipid parameters of these patients were compared. Results: High-density lipoprotein (HDL) levels of Group-4 were higher than Group 1 and Group 2. There was no statistical difference in HDL cholesterol levels between Group 3 and the others. Triglyceride and very low-density lipoprotein levels were higher in Group 1. There was no difference in P wave dispersion between the groups. In echocardigraphy, epicardial fat tissue thickness of Group 1 was significantly higher. Prevalance of diastolic dysfunction was higher in Group 1 compared to Group 4. Conclusions: Insulin resistance itself is a risk factor for low HDL levels independent of obesity. When obesity is added to insulin resistance, other cardiovascular risk factors appear, like high triglyceride levels, increase in epicardial fat tissue thickness and presence of diastolic dysfunction. Early detection of insulin resistance may alert us to the risks of cardiovascular diseases.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"6 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139173596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nurcan KAÇMAZ KAT, N. Sensoy, M. Kuzeytemiz, Ö. Demir
Objectives: Pulmonary embolism (PE) is an important disease due to its mortality and morbidity-related clinical conditions. Patients with a high risk of death within 30 days are discriminated against with the help of various clinical scores. Non-alcoholic fatty liver disease (NAFLD) has been found to be associated with atherosclerosis. We aimed to investigate the effect of NAFLD on disease severity and early death rate in patients with pulmonary embolism. Methods: This retrospective study includes patients who applied to the emergency department with suspected pulmonary embolism and whose diagnosis was confirmed according to the results of the examination. In addition to confirming the diagnosis of PE, hepatic steatosis was detected and graded by tomographic examination of the liver and spleen. Disease severity was stratified by Simplified Pulmonary Embolism Severity Index (sPESI). Results: A total of 165 patients (105 with sPESI≥1 and 60 with sPESI<1 controls) were included. The rate of mortality was 12% (n=13) in the sPESI≥1 group. The prevalence of NAFLD was 64% and the prevalence of hepatosteatosis was similar according to disease severity and prognosis (67% vs. 58%; P=0.28 and 69% vs. 63%; P=0.77). Besides the effect of disease severity; chronic lung disease (CLD) and chronic kidney disease (CKD) were independently associated with poor prognosis by multivariate analysis [3.71 (1.02-13.46); P=0.04 and 15.89 (2.57-98.35); P=0.003]. Conclusion: No association between disease severity and prognosis was observed with NAFLD in acute PE disease.
{"title":"Prognostic value of non-alcoholic fatty liver disease in patients with pulmonary embolism","authors":"Nurcan KAÇMAZ KAT, N. Sensoy, M. Kuzeytemiz, Ö. Demir","doi":"10.18621/eurj.1353100","DOIUrl":"https://doi.org/10.18621/eurj.1353100","url":null,"abstract":"Objectives: Pulmonary embolism (PE) is an important disease due to its mortality and morbidity-related clinical conditions. Patients with a high risk of death within 30 days are discriminated against with the help of various clinical scores. Non-alcoholic fatty liver disease (NAFLD) has been found to be associated with atherosclerosis. We aimed to investigate the effect of NAFLD on disease severity and early death rate in patients with pulmonary embolism. Methods: This retrospective study includes patients who applied to the emergency department with suspected pulmonary embolism and whose diagnosis was confirmed according to the results of the examination. In addition to confirming the diagnosis of PE, hepatic steatosis was detected and graded by tomographic examination of the liver and spleen. Disease severity was stratified by Simplified Pulmonary Embolism Severity Index (sPESI). Results: A total of 165 patients (105 with sPESI≥1 and 60 with sPESI<1 controls) were included. The rate of mortality was 12% (n=13) in the sPESI≥1 group. The prevalence of NAFLD was 64% and the prevalence of hepatosteatosis was similar according to disease severity and prognosis (67% vs. 58%; P=0.28 and 69% vs. 63%; P=0.77). Besides the effect of disease severity; chronic lung disease (CLD) and chronic kidney disease (CKD) were independently associated with poor prognosis by multivariate analysis [3.71 (1.02-13.46); P=0.04 and 15.89 (2.57-98.35); P=0.003]. Conclusion: No association between disease severity and prognosis was observed with NAFLD in acute PE disease.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"13 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139175947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: Despite all technical advances, Peritonitis remains the most important peritoneal dialysis (PD) complication. Peritonitis causes complications such as additional hospitalization, technical failure, peritoneal membrane damage, consequent transition to hemodialysis, and death in this patient group. Early diagnosis, isolation of the causative pathogen with appropriate methods as soon as possible, and determination of antibiotic susceptibilities play a crucial role in solving the problem of treating peritonitis in PD. This study evaluated the frequency of peritonitis, culture positivity rate, and prognosis in peritoneal dialysis patients in our unit for 12 years. Methods: A total of 171 patients (80 F, 91 M; mean age: 51.9±15.3 year; mean PD duration 36.5±36.4 months) who were followed up in our department between January 2009 and July 2021 were included in the study. Patient records were retrospectively analyzed. Results: Peritonitis never occurred in 105 of the 171 patients included in the study. Of the remaining 66 patients, 43 had one peritonitis attack, and 23 had more than two. The mean peritonitis rate was 1.68±1.36. One hundred eleven episodes of peritonitis were detected in 66 of the patients. Bacterial growth was observed in 63.06% of the culture samples obtained from the 93 peritonitis episodes. The peritoneal catheter was withdrawn in 14 (21.21%) cases. Conclusion: In our unit, the rate of culture positivity was 63.06%, and the peritonitis attack rate was 0.017 per patient-month and 0.211 per patient-year over a period of twelve years, with a mean of 57.1 patient months of peritonitis.
{"title":"Peritonitis in patients on peritoneal dialysis: a 12-year experience from a large medical center in Bursa","authors":"Bülent Gül","doi":"10.18621/eurj.1372796","DOIUrl":"https://doi.org/10.18621/eurj.1372796","url":null,"abstract":"Objectives: Despite all technical advances, Peritonitis remains the most important peritoneal dialysis (PD) complication. Peritonitis causes complications such as additional hospitalization, technical failure, peritoneal membrane damage, consequent transition to hemodialysis, and death in this patient group. Early diagnosis, isolation of the causative pathogen with appropriate methods as soon as possible, and determination of antibiotic susceptibilities play a crucial role in solving the problem of treating peritonitis in PD. This study evaluated the frequency of peritonitis, culture positivity rate, and prognosis in peritoneal dialysis patients in our unit for 12 years. Methods: A total of 171 patients (80 F, 91 M; mean age: 51.9±15.3 year; mean PD duration 36.5±36.4 months) who were followed up in our department between January 2009 and July 2021 were included in the study. Patient records were retrospectively analyzed. Results: Peritonitis never occurred in 105 of the 171 patients included in the study. Of the remaining 66 patients, 43 had one peritonitis attack, and 23 had more than two. The mean peritonitis rate was 1.68±1.36. One hundred eleven episodes of peritonitis were detected in 66 of the patients. Bacterial growth was observed in 63.06% of the culture samples obtained from the 93 peritonitis episodes. The peritoneal catheter was withdrawn in 14 (21.21%) cases. Conclusion: In our unit, the rate of culture positivity was 63.06%, and the peritonitis attack rate was 0.017 per patient-month and 0.211 per patient-year over a period of twelve years, with a mean of 57.1 patient months of peritonitis.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"42 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139176219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To assess the cross-sectional area (CSA) of the right and left internal jugular veins (IJVs) in the adult Turkish population. Methods: The CSA of the IJVs was quantified at three anatomical landmarks: below the angle of the mandible, at the level of the cricothyroid membrane, and in the supraclavicular region. Measurements were taken under three conditions: at rest, during a deep breath hold, and throughout the Valsalva maneuver. Results: The study encompassed 321 volunteers with a mean age of 30.40±7.75 years. At the anatomical landmarks of the angle of the mandible, cricothyroid, and supraclavicular regions, the CSA of the IJV in men was consistently larger than in women during rest, deep breath hold, and the Valsalva maneuver. During both the deep breath hold and the Valsalva maneuver at these landmarks, the right CSA of the IJV in both genders was greater than the left CSA. In both males and females, the CSA of the IJV at the supraclavicular location was superior to that at both the angle of the mandible and the cricothyroid regions. The CSA at the cricothyroid regions surpassed that at the angle of the mandible. Conclusions: The CSA of the IJV was found to be the largest in the right supraclavicular region during the Valsalva maneuver in both genders. By accurately measuring the CSA of the IJV at the angle of the mandible, cricothyroid, and supraclavicular anatomical landmarks during a deep breath hold and the Valsalva maneuver, potential interventional and surgical risks can be mitigated.
{"title":"Evaluating the cross-sectional area of the internal jugular vein in Turkish adults using ultrasonography","authors":"Doğa ÖZDEMİR KALKAN, Nezih Kavak","doi":"10.18621/eurj.1379905","DOIUrl":"https://doi.org/10.18621/eurj.1379905","url":null,"abstract":"Objective: To assess the cross-sectional area (CSA) of the right and left internal jugular veins (IJVs) in the adult Turkish population.\u0000Methods: The CSA of the IJVs was quantified at three anatomical landmarks: below the angle of the mandible, at the level of the cricothyroid membrane, and in the supraclavicular region. Measurements were taken under three conditions: at rest, during a deep breath hold, and throughout the Valsalva maneuver.\u0000Results: The study encompassed 321 volunteers with a mean age of 30.40±7.75 years. At the anatomical landmarks of the angle of the mandible, cricothyroid, and supraclavicular regions, the CSA of the IJV in men was consistently larger than in women during rest, deep breath hold, and the Valsalva maneuver. During both the deep breath hold and the Valsalva maneuver at these landmarks, the right CSA of the IJV in both genders was greater than the left CSA. In both males and females, the CSA of the IJV at the supraclavicular location was superior to that at both the angle of the mandible and the cricothyroid regions. The CSA at the cricothyroid regions surpassed that at the angle of the mandible.\u0000Conclusions: The CSA of the IJV was found to be the largest in the right supraclavicular region during the Valsalva maneuver in both genders. By accurately measuring the CSA of the IJV at the angle of the mandible, cricothyroid, and supraclavicular anatomical landmarks during a deep breath hold and the Valsalva maneuver, potential interventional and surgical risks can be mitigated.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"40 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139000097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: Primary Hyperhidrosis (HH) is the excessive sweating condition in one or more parts of the body. The definitive treatment method is surgical. The most commonly applied surgical method is endoscopic thoracic sympathectomy (ETS). We aimed to investigate the effectiveness of patients with hyperhidrosis by making temperature measurements. Methods: We analyzed the findings of 30 patients who were diagnosed with HH between January 1, 2019 and November 1, 2022 in Kahramanmaraş Sütçü İmam University Thoracic Surgery Clinic. Preoperative, intraoperative and postoperative hand temperatures of the patients who underwent bilateral endoscopic thoracic sympathectomy were examined by measuring hand temperatures with a thermal camera. Results: After the evaluation of the examination, it was revealed that there was an increase in the hand temperature measurement values before sympathectomy and after the sympathectomy operation. Conclusion: We believe that endoscopic thoracic sympathectomy performed by measuring temperature with a thermal camera will increase the comfort and safety of the surgery both on the part of the physician and the patient.
{"title":"Use of perioperative thermal camera for the assessment of sympathectomy effectiveness","authors":"Ahmet Acıpayam, A. Yoldaş","doi":"10.18621/eurj.1364802","DOIUrl":"https://doi.org/10.18621/eurj.1364802","url":null,"abstract":"Objectives: Primary Hyperhidrosis (HH) is the excessive sweating condition in one or more parts of the body. The definitive treatment method is surgical. The most commonly applied surgical method is endoscopic thoracic sympathectomy (ETS). We aimed to investigate the effectiveness of patients with hyperhidrosis by making temperature measurements. \u0000Methods: We analyzed the findings of 30 patients who were diagnosed with HH between January 1, 2019 and November 1, 2022 in Kahramanmaraş Sütçü İmam University Thoracic Surgery Clinic. Preoperative, intraoperative and postoperative hand temperatures of the patients who underwent bilateral endoscopic thoracic sympathectomy were examined by measuring hand temperatures with a thermal camera. \u0000Results: After the evaluation of the examination, it was revealed that there was an increase in the hand temperature measurement values before sympathectomy and after the sympathectomy operation. \u0000Conclusion: We believe that endoscopic thoracic sympathectomy performed by measuring temperature with a thermal camera will increase the comfort and safety of the surgery both on the part of the physician and the patient.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"79 S49","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138976891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To determine the relationship between immunofluorescence microscopy findings and progression markers at the time of diagnosis in immunoglobulin A (IgA) nephropathy. Methods: Fifty-two patients with pathological diagnosis of primary IgA nephropathy by showing mesangial and mesangiocapillary IgA-dominant immune deposits in immunofluorescence microscopy were included in the study. At the time of biopsy, biochemical and hematological data, Oxford MEST score and immunofluorescent staining findings were recorded. The serum IgA/C3 ratio was calculated. The immunofluorescence results of the total group were compared with the markers of progression at the time of diagnosis, estimated glomerular filtration rate (eGFR), hematuria, proteinuria, creatinine, and serum IgA/C3 ratio. Results: The mean age of the study group was 39.9±12.3 years and 55.8% were male. eGFR, albumin, hemoglobin, IgM were significantly lower, and uric acid and hematuria were significantly higher in those with proteinuria above 1 g compared to those with low proteinuria. A positive correlation was found between IgA, C3 and lambda staining and hematuria. There was a positive correlation between C3 staining and creatinine, and a positive correlation with hematuria. A correlation was found between Kappa staining and eGFR. Conclusion: Correlation was found between IgA, C3 and lambda staining and hematuria at the time of diagnosis in IgA nephropathy.
目的确定免疫荧光显微镜检查结果与免疫球蛋白 A（IgA）肾病诊断时的进展标志物之间的关系。方法研究纳入了 52 例病理诊断为原发性 IgA 肾病的患者，这些患者在免疫荧光显微镜下显示间质和间质毛细血管 IgA 优势免疫沉积。活检时，记录了生化和血液学数据、牛津 MEST 评分和免疫荧光染色结果。计算血清 IgA/C3 比值。将全组的免疫荧光结果与诊断时的病情进展指标、估计肾小球滤过率（eGFR）、血尿、蛋白尿、肌酐和血清 IgA/C3 比值进行比较。研究结果研究组平均年龄为（39.9±12.3）岁，55.8%为男性。与低蛋白尿患者相比，蛋白尿超过 1 克者的 eGFR、白蛋白、血红蛋白、IgM 显著降低，尿酸和血尿显著升高。IgA、C3和λ染色与血尿呈正相关。C3 染色与肌酐呈正相关，与血尿呈正相关。Kappa 染色与 eGFR 之间存在相关性。结论在诊断 IgA 肾病时，IgA、C3 和 lambda 染色与血尿之间存在相关性。
{"title":"The relationship between immun staining and progression markers in IgA nephropathy","authors":"Semahat Karahisar Şirali, R. Büberci̇","doi":"10.18621/eurj.1311453","DOIUrl":"https://doi.org/10.18621/eurj.1311453","url":null,"abstract":"Objective: To determine the relationship between immunofluorescence microscopy findings and progression markers at the time of diagnosis in immunoglobulin A (IgA) nephropathy. \u0000Methods: Fifty-two patients with pathological diagnosis of primary IgA nephropathy by showing mesangial and mesangiocapillary IgA-dominant immune deposits in immunofluorescence microscopy were included in the study. At the time of biopsy, biochemical and hematological data, Oxford MEST score and immunofluorescent staining findings were recorded. The serum IgA/C3 ratio was calculated. The immunofluorescence results of the total group were compared with the markers of progression at the time of diagnosis, estimated glomerular filtration rate (eGFR), hematuria, proteinuria, creatinine, and serum IgA/C3 ratio. \u0000Results: The mean age of the study group was 39.9±12.3 years and 55.8% were male. eGFR, albumin, hemoglobin, IgM were significantly lower, and uric acid and hematuria were significantly higher in those with proteinuria above 1 g compared to those with low proteinuria. A positive correlation was found between IgA, C3 and lambda staining and hematuria. There was a positive correlation between C3 staining and creatinine, and a positive correlation with hematuria. A correlation was found between Kappa staining and eGFR. \u0000Conclusion: Correlation was found between IgA, C3 and lambda staining and hematuria at the time of diagnosis in IgA nephropathy.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"103 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138978518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: The aim of this study is to reveal the diagnostic yield of the progressive familial intrahepatic cholestasis (PFIC) gene panel that we have used in the diagnosis of this patient group, which accounts for approximately 10% of cholestatic liver disease, and to report the clinical findings of our patients with the detected variants. Methods: In this study, we retrospectively evaluated the results of molecular genetic analysis of pediatric patients whose PFIC gene panel contained the ATP8B1, ABCB11, and ABCB4 genes. Results: In 10 patients, 12 different variants were detected that could explain the PFIC clinical picture. Three of these variants were considered novel variants. Conclusion: Our study demonstrates the usefulness of the NGS panel in diagnosing pediatric patients with PFIC findings. This diagnostic method also contributed to the variant spectrum of PFIC-related genes.
{"title":"Next-generation sequencing panel test results in pediatric patients with progressive familial intrahepatic cholestasis: a single-center experience","authors":"Ali TOPAK","doi":"10.18621/eurj.1340536","DOIUrl":"https://doi.org/10.18621/eurj.1340536","url":null,"abstract":"Objective: The aim of this study is to reveal the diagnostic yield of the progressive familial intrahepatic cholestasis (PFIC) gene panel that we have used in the diagnosis of this patient group, which accounts for approximately 10% of cholestatic liver disease, and to report the clinical findings of our patients with the detected variants. Methods: In this study, we retrospectively evaluated the results of molecular genetic analysis of pediatric patients whose PFIC gene panel contained the ATP8B1, ABCB11, and ABCB4 genes. Results: In 10 patients, 12 different variants were detected that could explain the PFIC clinical picture. Three of these variants were considered novel variants. Conclusion: Our study demonstrates the usefulness of the NGS panel in diagnosing pediatric patients with PFIC findings. This diagnostic method also contributed to the variant spectrum of PFIC-related genes.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135728297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The primary aim of this study is to review the transformation of occupational health and safety (OHS) practices in the digital age, particularly in light of the onset of Industry 4.0. The study seeks to understand the emergence of OHS 4.0 methodologies and their implications for enhancing performance, reducing risks, and addressing workplace challenges. The overarching objective is to explore the innovations in the OHS domain influenced by digitalization and ascertain the benefits and challenges of integrating digital methodologies into OHS practices. A comprehensive literature review was conducted, scanning multiple sources to gather insights on the innovations brought about by digitalization in the OHS domain. The study further analyzed contemporary research and application areas of new technologies in occupational health and safety. Findings from the study confirm that the integration of digital technologies into the OHS domain can lead to a significant reduction in workplace accidents. However, as workplaces embrace digital processes, new types of risks emerge for employees. In adapting to digitalization, there are recognized challenges in areas like privacy, security, clarity, and responsibility. Digitalization has redefined the landscape of OHS, ushering in an era of OHS 4.0. While the digital methodologies offer significant advantages in reducing workplace accidents and enhancing performance, they also present new risks and challenges. As the workplace undergoes rapid changes due to technological advancements, there's a pressing need to develop OHS approaches that align with the demands of the modern age, ensuring that health and safety remain paramount amidst uncertainties in applicability.
{"title":"Integration of digitalization into occupational health and safety and its applicability: a literature review","authors":"Cengiz AKYILDIZ","doi":"10.18621/eurj.1352743","DOIUrl":"https://doi.org/10.18621/eurj.1352743","url":null,"abstract":"The primary aim of this study is to review the transformation of occupational health and safety (OHS) practices in the digital age, particularly in light of the onset of Industry 4.0. The study seeks to understand the emergence of OHS 4.0 methodologies and their implications for enhancing performance, reducing risks, and addressing workplace challenges. The overarching objective is to explore the innovations in the OHS domain influenced by digitalization and ascertain the benefits and challenges of integrating digital methodologies into OHS practices. A comprehensive literature review was conducted, scanning multiple sources to gather insights on the innovations brought about by digitalization in the OHS domain. The study further analyzed contemporary research and application areas of new technologies in occupational health and safety. Findings from the study confirm that the integration of digital technologies into the OHS domain can lead to a significant reduction in workplace accidents. However, as workplaces embrace digital processes, new types of risks emerge for employees. In adapting to digitalization, there are recognized challenges in areas like privacy, security, clarity, and responsibility. Digitalization has redefined the landscape of OHS, ushering in an era of OHS 4.0. While the digital methodologies offer significant advantages in reducing workplace accidents and enhancing performance, they also present new risks and challenges. As the workplace undergoes rapid changes due to technological advancements, there's a pressing need to develop OHS approaches that align with the demands of the modern age, ensuring that health and safety remain paramount amidst uncertainties in applicability.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"13 8","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135728313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: While clinical and radiological awareness of the usual, frequent metastatic sites of breast cancer is high, unexpected 'atypical' localisations may be more easily overlooked in the cancer management process. The aim of this article is to contribute to this awareness in order to facilitate and improve the diagnosis and follow-up of breast cancer. Methods: In this study, we retrospectively evaluated breast cancer patients who were diagnosed and followed up between 2017 and 2022 in our hospital, which is an important oncology center. Results: Of the 852 patients included in this study, 79 had an unusual metastasis localization. The most common unusual metastasis sites were mediastinal lymph nodes and brain. These sites were followed by atypical bone involvement, mesenteric lymph nodes, cervical lymph nodes, hilar lymph nodes and surrenal metastases. The most rare metastases were more common in the uterus and ovary, followed by pancreas, parotid gland, spleen, colon, pericardium-atrium, orbital soft tissues and lacrimal gland. . The unusual site of metastasis was mediastinal lymph nodes in 17.7% (n = 14), brain in 17.7% (n = 14), atypical bone sites in 12.6% (n = 10), mesenteric lymph nodes in 11.3% (n = 9), cervical lymph nodes in 11.3% (n = 9), hilar lymph nodes in 5% (n = 4) and surrenal in 6.3% (n = 5). Conclusions: Sharing knowledge and experience about unusual metastases of breast cancer will contribute to the diagnosis and treatment of metastatic diseases by increasing the awareness of this issue. For this, multicentre studies should be conducted to combine these experiences.
{"title":"Unusual metastases of breast cancer: a single-center retrospective study","authors":"Pınar ÖZDEMİR AKDUR, Nazan ÇİLEDAĞ","doi":"10.18621/eurj.1354513","DOIUrl":"https://doi.org/10.18621/eurj.1354513","url":null,"abstract":"Objectives: While clinical and radiological awareness of the usual, frequent metastatic sites of breast cancer is high, unexpected 'atypical' localisations may be more easily overlooked in the cancer management process. The aim of this article is to contribute to this awareness in order to facilitate and improve the diagnosis and follow-up of breast cancer. Methods: In this study, we retrospectively evaluated breast cancer patients who were diagnosed and followed up between 2017 and 2022 in our hospital, which is an important oncology center. Results: Of the 852 patients included in this study, 79 had an unusual metastasis localization. The most common unusual metastasis sites were mediastinal lymph nodes and brain. These sites were followed by atypical bone involvement, mesenteric lymph nodes, cervical lymph nodes, hilar lymph nodes and surrenal metastases. The most rare metastases were more common in the uterus and ovary, followed by pancreas, parotid gland, spleen, colon, pericardium-atrium, orbital soft tissues and lacrimal gland. . The unusual site of metastasis was mediastinal lymph nodes in 17.7% (n = 14), brain in 17.7% (n = 14), atypical bone sites in 12.6% (n = 10), mesenteric lymph nodes in 11.3% (n = 9), cervical lymph nodes in 11.3% (n = 9), hilar lymph nodes in 5% (n = 4) and surrenal in 6.3% (n = 5). Conclusions: Sharing knowledge and experience about unusual metastases of breast cancer will contribute to the diagnosis and treatment of metastatic diseases by increasing the awareness of this issue. For this, multicentre studies should be conducted to combine these experiences.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"13 7","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135728314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: This study aims to determine how the dream themes of borderline personality disorder patients differ from those of without borderline personality disorder diagnosis and the mediating role of rejection sensitivity in this differentiation process. Methods: The convenience sampling method was used in the study, and the participants were 79 female borderline patients diagnosed with semi-structured interviews with criteria of DSM-5 and 79 female individuals who had not received a psychological diagnosis before and at the study interviews. Sociodemographic Information Form, Dream Themes Scale, Borderline Personality Questionnaire, and Rejection Sensitivity Scale were used in the study. Linear Regression Analysis, Hierarchical Regression Analysis, and Independent Groups T-Test were used during the investigations. Results: Borderline personality disorder patients scored higher in all sub-dimensions of the dream themes scale and rejection sensitivity scale than the control group. Borderline personality traits predicted rejection sensitivity. Borderline personality traits and rejection sensitivity together predicted dream themes. Borderline personality predicts anxiety dreams, fear dreams, and experience dreams, and rejection sensitivity mediates these predictive relationships. Conclusions: The dreams of borderline personality disorder patients have negative content covered by the impact of experiences sub-dimension on dream themes, as they contain reflections of negative content in beliefs, thoughts and emotions related to their daily lives. Rejection sensitivity plays a mediator role in borderline patient’s dreams. The study results show that it would be beneficial not to ignore the content of dreams in patients with borderline personality disorder, considering the relationship of negative dreams with daily functioning, dissociative symptoms, self-harming behaviors, and suicide attempts. Results also indicate that it might be beneficial to target rejection sensitivity to reduce aggravating dream contents.
{"title":"Dream themes and rejection sensitivity of individuals with and without borderline personality disorder: a comparative study","authors":"Haydeh FARAJİ","doi":"10.18621/eurj.1357324","DOIUrl":"https://doi.org/10.18621/eurj.1357324","url":null,"abstract":"Objectives: This study aims to determine how the dream themes of borderline personality disorder patients differ from those of without borderline personality disorder diagnosis and the mediating role of rejection sensitivity in this differentiation process. Methods: The convenience sampling method was used in the study, and the participants were 79 female borderline patients diagnosed with semi-structured interviews with criteria of DSM-5 and 79 female individuals who had not received a psychological diagnosis before and at the study interviews. Sociodemographic Information Form, Dream Themes Scale, Borderline Personality Questionnaire, and Rejection Sensitivity Scale were used in the study. Linear Regression Analysis, Hierarchical Regression Analysis, and Independent Groups T-Test were used during the investigations. Results: Borderline personality disorder patients scored higher in all sub-dimensions of the dream themes scale and rejection sensitivity scale than the control group. Borderline personality traits predicted rejection sensitivity. Borderline personality traits and rejection sensitivity together predicted dream themes. Borderline personality predicts anxiety dreams, fear dreams, and experience dreams, and rejection sensitivity mediates these predictive relationships. Conclusions: The dreams of borderline personality disorder patients have negative content covered by the impact of experiences sub-dimension on dream themes, as they contain reflections of negative content in beliefs, thoughts and emotions related to their daily lives. Rejection sensitivity plays a mediator role in borderline patient’s dreams. The study results show that it would be beneficial not to ignore the content of dreams in patients with borderline personality disorder, considering the relationship of negative dreams with daily functioning, dissociative symptoms, self-harming behaviors, and suicide attempts. Results also indicate that it might be beneficial to target rejection sensitivity to reduce aggravating dream contents.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"38 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134909072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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