Objectives: The aim of the research is to determine the nutrition literacy level and food safety awareness level of students who studied at faculty of health sciences. This descriptive study also demonstrates university students’ nutrition literacy statuses, food safety attitudes, nutritional statuses, and food preferences. Methods: The research was conducted as a descriptive and cross-sectional survey study in order to determine the nutrition literacy level and food safety awareness level of the students. Two hundred and eight individuals, including 174 women and 34 men, participated in the study. The data were obtained from face-to-face and online interviews then they were analyzed in a software. The survey is consisted of three parts: socio-demographic form, Evaluation Instrument of Nutrition Literacy on Adults and the Food Safety Attitude scale. Results: In this study, the majority of the participants studied in the department of nutrition and dietetics (55.29%) and audiology (26.92%), followed by health management (7.21%), physiology and rehabilitation (5.77%), nursing (4.33%) and social work (0.48%) department. The relationship between nutrition literacy and food safety among the students of the faculty of health sciences was significant (p < 0.01). Conclusions: This study showed that the nutrition literacy level was sufficient and the food safety attitude was positive in university students. However, it is needed to prospective studies to understand the importance of nutrition literacy and food safety awareness.
{"title":"Determining the level of food safety awareness by nutritional literacy in health sciences faculty students","authors":"Aliye Yaprak Sevi̇nç, Ülkü Demi̇rci̇","doi":"10.18621/eurj.1272648","DOIUrl":"https://doi.org/10.18621/eurj.1272648","url":null,"abstract":"Objectives: The aim of the research is to determine the nutrition literacy level and food safety awareness level of students who studied at faculty of health sciences. This descriptive study also demonstrates university students’ nutrition literacy statuses, food safety attitudes, nutritional statuses, and food preferences.\u0000Methods: The research was conducted as a descriptive and cross-sectional survey study in order to determine the nutrition literacy level and food safety awareness level of the students. Two hundred and eight individuals, including 174 women and 34 men, participated in the study. The data were obtained from face-to-face and online interviews then they were analyzed in a software. The survey is consisted of three parts: socio-demographic form, Evaluation Instrument of Nutrition Literacy on Adults and the Food Safety Attitude scale.\u0000Results: In this study, the majority of the participants studied in the department of nutrition and dietetics (55.29%) and audiology (26.92%), followed by health management (7.21%), physiology and rehabilitation (5.77%), nursing (4.33%) and social work (0.48%) department. The relationship between nutrition literacy and food safety among the students of the faculty of health sciences was significant (p < 0.01).\u0000Conclusions: This study showed that the nutrition literacy level was sufficient and the food safety attitude was positive in university students. However, it is needed to prospective studies to understand the importance of nutrition literacy and food safety awareness.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90594866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: Our study examined the effects of the trophectoderm biopsy (TB) day and the presence of necrotic foci (NF) or separate blastomeres (SB) within euploid embryos on in vitro fertilization (IVF) pregnancy outcomes. Methods: This retrospective cohort study was conducted from January 2017 to September 2021 at Memorial Sisli Hospital, Istanbul, Turkey. The study comprised a total of 2758 frozen-thawed euploid embryo transfer cycles. After thawing, blastocysts were graded using Gardner's classification Top-Quality (TQ), Good-Quality (GQ), Moderate-Quality (MQ), Poor-Quality (PQ) and further divided into groups according to the presence of NF and/or SB and evaluated for pregnancy outcomes. Results: There were significant correlations between pregnancy outcomes and the degree of blastocoele expansion, as well as the presence of NF or SB in the euploid embryo. Ongoing pregnancy rates were lower in the group with NF in the inner cell mass (ICM) or trophectoderm (TE) than in the group without NF. The presence of SB decreased the rates of ongoing pregnancy and increased the rates of miscarriage. Embryos with expansion grades ≤ 3 had lower rates of ongoing pregnancy and higher rates of miscarriage compared to embryos with expansion grades> 3. TQ and GQ embryos had a higher rate of ongoing pregnancy and a lower rate of miscarriage than MQ and PQ embryos. Conclusions: When selecting the embryo to be transferred to a patient, careful consideration should be given to the morphological grade of the embryo as well as whether or not it contains NF and SB.
{"title":"Effects of embryo characteristics in frozen-thawed single euploid blastocyst transfers on pregnancy outcomes: a retrospective cohort study","authors":"Gönül Özer, Gulçin Özkara","doi":"10.18621/eurj.1346766","DOIUrl":"https://doi.org/10.18621/eurj.1346766","url":null,"abstract":"Objectives: Our study examined the effects of the trophectoderm biopsy (TB) day and the presence of necrotic foci (NF) or separate blastomeres (SB) within euploid embryos on in vitro fertilization (IVF) pregnancy outcomes. \u0000Methods: This retrospective cohort study was conducted from January 2017 to September 2021 at Memorial Sisli Hospital, Istanbul, Turkey. The study comprised a total of 2758 frozen-thawed euploid embryo transfer cycles. After thawing, blastocysts were graded using Gardner's classification Top-Quality (TQ), Good-Quality (GQ), Moderate-Quality (MQ), Poor-Quality (PQ) and further divided into groups according to the presence of NF and/or SB and evaluated for pregnancy outcomes. \u0000Results: There were significant correlations between pregnancy outcomes and the degree of blastocoele expansion, as well as the presence of NF or SB in the euploid embryo. Ongoing pregnancy rates were lower in the group with NF in the inner cell mass (ICM) or trophectoderm (TE) than in the group without NF. The presence of SB decreased the rates of ongoing pregnancy and increased the rates of miscarriage. Embryos with expansion grades ≤ 3 had lower rates of ongoing pregnancy and higher rates of miscarriage compared to embryos with expansion grades> 3. TQ and GQ embryos had a higher rate of ongoing pregnancy and a lower rate of miscarriage than MQ and PQ embryos. \u0000Conclusions: When selecting the embryo to be transferred to a patient, careful consideration should be given to the morphological grade of the embryo as well as whether or not it contains NF and SB.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89229305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: Acute myocarditis/myopericarditis is a heterogeneous disorder of unknown origin, the viral etiology leading the first row. There could be also myocardial involvement in multisystem inflammatory syndrome in children (MIS-C). In this study, we aimed to investigate cardiac biomarkers of acute myocarditis/myopericarditis and MIS-C and to compare these parameters between the two diseases. Methods: Patients who are diagnosed with MIS-C, isolated viral myocarditis/myopericarditis at a university hospital from October 2021 to March 2023 are included in this study. Results: There were 38 MIS-C patients and 53 patients with myocarditis/myopericarditis. The mean age was 141.2 ± 38.2 months (4 to 18 years old) in MISC, and 145.8 ± 52.1 months (7 to 18 years old) in myocarditis/myopericarditis. Median troponin I level was 145 ng/L in MIS-C patients and it was 901 ng/L in myocarditis/myopericarditis patients. Creatinine kinase-myocardial band (CK-MB) median was 2.25 ng/mL (0.6-6.3) versus 6.7 ng/mL in MIS-C and myocarditis/myopericarditis, respectively. Pro Brain natriuretic peptide (Pro-BNP) median level was 2714.5 pg/mL (<300) in MIS-C, and it was 294 in patients with myocarditis/myopericarditis. Troponin I, CK-MB was significantly higher in myocarditis/myopericarditis, while Pro-BNP was significantly higher in MIS-C patients (p < 0.05). The separating power of CK-MB, troponin I, and Pro-BNP level was significantly higher in the differential diagnosis of these two group patients (p < 0.001). MIS-C patients with high pro-BNP levels had more prolonged hospitalization and left ventricular function impairment according to myocarditis/myopericarditis. Conclusions: Cardiac biomarkers (CK-MB, troponin I, and Pro-BNP) could be good markers to estimate the course of the diseases.
{"title":"Cardiac biomarkers comparison between acute myocarditis/myopericarditis and multisystem inflammatory syndrome in children","authors":"D. Duman, D. Karpuz","doi":"10.18621/eurj.1347674","DOIUrl":"https://doi.org/10.18621/eurj.1347674","url":null,"abstract":"Objectives: Acute myocarditis/myopericarditis is a heterogeneous disorder of unknown origin, the viral etiology leading the first row. There could be also myocardial involvement in multisystem inflammatory syndrome in children (MIS-C). In this study, we aimed to investigate cardiac biomarkers of acute myocarditis/myopericarditis and MIS-C and to compare these parameters between the two diseases. \u0000Methods: Patients who are diagnosed with MIS-C, isolated viral myocarditis/myopericarditis at a university hospital from October 2021 to March 2023 are included in this study. \u0000Results: There were 38 MIS-C patients and 53 patients with myocarditis/myopericarditis. The mean age was 141.2 ± 38.2 months (4 to 18 years old) in MISC, and 145.8 ± 52.1 months (7 to 18 years old) in myocarditis/myopericarditis. Median troponin I level was 145 ng/L in MIS-C patients and it was 901 ng/L in myocarditis/myopericarditis patients. Creatinine kinase-myocardial band (CK-MB) median was 2.25 ng/mL (0.6-6.3) versus 6.7 ng/mL in MIS-C and myocarditis/myopericarditis, respectively. Pro Brain natriuretic peptide (Pro-BNP) median level was 2714.5 pg/mL (<300) in MIS-C, and it was 294 in patients with myocarditis/myopericarditis. Troponin I, CK-MB was significantly higher in myocarditis/myopericarditis, while Pro-BNP was significantly higher in MIS-C patients (p < 0.05). The separating power of CK-MB, troponin I, and Pro-BNP level was significantly higher in the differential diagnosis of these two group patients (p < 0.001). MIS-C patients with high pro-BNP levels had more prolonged hospitalization and left ventricular function impairment according to myocarditis/myopericarditis. \u0000Conclusions: Cardiac biomarkers (CK-MB, troponin I, and Pro-BNP) could be good markers to estimate the course of the diseases.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75352053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: Our study aimed to investigate the sensitivity of the abbreviated magnetic resonance imaging (MRI) in the detection of tumors in breast cancer patients. Methods: Patients who underwent breast MRI between March 2018 and October 2021 were reviewed retrospectively. Patients with a histologic diagnosis of breast malignancy were included in the study. Patients who underwent a biopsy or an interventional procedure before the MRI examination and who received neoadjuvant chemotherapy were excluded from the study. Abbreviated MR protocol included a pre-contrast T1-weighted, 1st minute contrast-enhanced T1-weighted, and 1st minute subtracted series. Additionally, 2nd minute post-contrast series were evaluated. Results: A total of 83 lesions with a histologic diagnosis of breast cancer were evaluated in 81 patients. The mean age of the patients included in the study was 51.08 years (range: 27-79 years). Seventy-four of the 83 breast lesions showed contrast enhancement in the 1st minute contrast-enhanced images and subtraction images (sensitivity 89.1%). When missed cases were re-evaluated all of them were visible in the second-minute contrast-enhanced series. Conclusions: In this study, malignant lesions could be detected with high-sensitivity abbreviated MRI protocol and the addition of second-minute contrast-enhanced series to the protocol significantly improve lesion detection. We believe that MRI with the abbreviated MRI protocol can be used for screening purposes in high-risk women with dense breasts.
{"title":"Evaluation of malignant breast masses with abbreviated breast magnetic resonance imaging","authors":"E. Yılmaz, N. Güldoğan","doi":"10.18621/eurj.1342470","DOIUrl":"https://doi.org/10.18621/eurj.1342470","url":null,"abstract":"Objectives: Our study aimed to investigate the sensitivity of the abbreviated magnetic resonance imaging (MRI) in the detection of tumors in breast cancer patients.\u0000Methods: Patients who underwent breast MRI between March 2018 and October 2021 were reviewed retrospectively. Patients with a histologic diagnosis of breast malignancy were included in the study. Patients who underwent a biopsy or an interventional procedure before the MRI examination and who received neoadjuvant chemotherapy were excluded from the study. Abbreviated MR protocol included a pre-contrast T1-weighted, 1st minute contrast-enhanced T1-weighted, and 1st minute subtracted series. Additionally, 2nd minute post-contrast series were evaluated. \u0000Results: A total of 83 lesions with a histologic diagnosis of breast cancer were evaluated in 81 patients. The mean age of the patients included in the study was 51.08 years (range: 27-79 years). Seventy-four of the 83 breast lesions showed contrast enhancement in the 1st minute contrast-enhanced images and subtraction images (sensitivity 89.1%). When missed cases were re-evaluated all of them were visible in the second-minute contrast-enhanced series. \u0000Conclusions: In this study, malignant lesions could be detected with high-sensitivity abbreviated MRI protocol and the addition of second-minute contrast-enhanced series to the protocol significantly improve lesion detection. We believe that MRI with the abbreviated MRI protocol can be used for screening purposes in high-risk women with dense breasts.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81992816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sibel DOĞAN KAYA, Güliz Evik, Münire Deni̇z, Yeşim Uygun Kızmaz
Objectives: Infection is a frequent complication of organ transplantation and is associated with significant morbidity and mortality. Methods: Patients who had liver and kidney transplants between 2011 and 2022, who were hospitalized in our hospital, and who were consulted for infectious diseases were retrospectively analyzed from hospital records. Results: Of the patients included in the study, 9 (28%) were female, 23 (72%) were male, and the mean age was 33.7 ± 11.3 years. Patients had congestive heart failure (87.2%, n = 28, hypertension (43.7%, n = 14), and chronic obstructive pulmonary disease (21.8%, n = 7). Twenty (62.5%) kidney transplant recipients and 12 (37.5%) liver transplant recipients were seen within ten years. The most common infections were urinary tract infection in 8 ( 25%) patients and pneumonia in 11 (34.3%). The other infections were gastrointestinal infections such as diarrhoea, bloodstream infections and COVID-19 and Cytomegalovirus. Culture-isolated organisms in 20 (62.5%) of the 32 patients admitted with infections. The microbiological data were notable for some unusual and opportunistic pathogens, including one case of acute cytomegalovirus viremia. Severe sepsis had been seen in six (18.75%) out of 32 patients with documented infections. Conclusions: Infection prevention has become a cornerstone of modern transplantation medicine due to the significant incidence of post-transplant infectious complications resulting from improved immunosuppressive therapies and surgical procedures.
{"title":"Evaluation of infections in patients with kidney and liver transplantation","authors":"Sibel DOĞAN KAYA, Güliz Evik, Münire Deni̇z, Yeşim Uygun Kızmaz","doi":"10.18621/eurj.1340605","DOIUrl":"https://doi.org/10.18621/eurj.1340605","url":null,"abstract":"Objectives: Infection is a frequent complication of organ transplantation and is associated with significant morbidity and mortality. \u0000Methods: Patients who had liver and kidney transplants between 2011 and 2022, who were hospitalized in our hospital, and who were consulted for infectious diseases were retrospectively analyzed from hospital records. \u0000Results: Of the patients included in the study, 9 (28%) were female, 23 (72%) were male, and the mean age was 33.7 ± 11.3 years. Patients had congestive heart failure (87.2%, n = 28, hypertension (43.7%, n = 14), and chronic obstructive pulmonary disease (21.8%, n = 7). Twenty (62.5%) kidney transplant recipients and 12 (37.5%) liver transplant recipients were seen within ten years. The most common infections were urinary tract infection in 8 ( 25%) patients and pneumonia in 11 (34.3%). The other infections were gastrointestinal infections such as diarrhoea, bloodstream infections and COVID-19 and Cytomegalovirus. Culture-isolated organisms in 20 (62.5%) of the 32 patients admitted with infections. The microbiological data were notable for some unusual and opportunistic pathogens, including one case of acute cytomegalovirus viremia. Severe sepsis had been seen in six (18.75%) out of 32 patients with documented infections. \u0000Conclusions: Infection prevention has become a cornerstone of modern transplantation medicine due to the significant incidence of post-transplant infectious complications resulting from improved immunosuppressive therapies and surgical procedures.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"84 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77138508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: Adenotonsillar hypertrophy (AH) is a prevalent condition in children that can cause significant complications if left untreated. In this study, we investigated the impact of adenoidectomy on pulmonary function tests (PFTs) and explored the relationship between spirometric parameters in affected children. By evaluating these factors, we can better understand the post-surgical outcomes and the potential benefits of surgical intervention. Methods: The present study utilized a prospective controlled design to conduct a before and after clinical trial involving 23 children diagnosed with upper airway obstruction resulting from AH. Five specific spirometric parameters were selected to evaluate pulmonary function before and 1-3 months following the adenoidectomy procedure. Additionally, adenoid grade scores and gender differences were recorded for each patient to assess their effect on the lung. Results: Peak expiratory flow (PEF) (p = 0.002), the first second of expiration (FEV1) (p < 0.001), and the ratio of FEV1/FVC (p = 0.001) significantly increased postoperatively. However, no significant correlations were found between the forced vital capacity (FVC) (p = 0.39) and mid-expiratory forced expiratory flow (FEF25-75) (p = 0.2). Rising of the FVC, PEF, FEV1, and FEV1/FVC was observed in AH grade III patients compared to AH grade IV patients following the surgical intervention, in comparison to the preoperative baseline, especially statistical significance was FEV (p = 0.047), indicating a noteworthy change in lung function. Conclusions: These findings emphasize the beneficial effects of adenoidectomy on PFTs and highlight that adenoidectomy positively affects the upper and lower airways.
{"title":"The effect of adenoidectomy on pulmonary function in children: prospective controlled study","authors":"Ozlem YAGIZ AGAYAROV, A. Aliyeva, S. Kocahan","doi":"10.18621/eurj.1340980","DOIUrl":"https://doi.org/10.18621/eurj.1340980","url":null,"abstract":"Objectives: Adenotonsillar hypertrophy (AH) is a prevalent condition in children that can cause significant complications if left untreated. In this study, we investigated the impact of adenoidectomy on pulmonary function tests (PFTs) and explored the relationship between spirometric parameters in affected children. By evaluating these factors, we can better understand the post-surgical outcomes and the potential benefits of surgical intervention.\u0000Methods: The present study utilized a prospective controlled design to conduct a before and after clinical trial involving 23 children diagnosed with upper airway obstruction resulting from AH. Five specific spirometric parameters were selected to evaluate pulmonary function before and 1-3 months following the adenoidectomy procedure. Additionally, adenoid grade scores and gender differences were recorded for each patient to assess their effect on the lung.\u0000Results: Peak expiratory flow (PEF) (p = 0.002), the first second of expiration (FEV1) (p < 0.001), and the ratio of FEV1/FVC (p = 0.001) significantly increased postoperatively. However, no significant correlations were found between the forced vital capacity (FVC) (p = 0.39) and mid-expiratory forced expiratory flow (FEF25-75) (p = 0.2). Rising of the FVC, PEF, FEV1, and FEV1/FVC was observed in AH grade III patients compared to AH grade IV patients following the surgical intervention, in comparison to the preoperative baseline, especially statistical significance was FEV (p = 0.047), indicating a noteworthy change in lung function.\u0000Conclusions: These findings emphasize the beneficial effects of adenoidectomy on PFTs and highlight that adenoidectomy positively affects the upper and lower airways.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"185 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78734211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Şahi̇n, E. Çubukçu, A. Deligönül, B. Ocak, H. Melek, Buket ERKAN OZMARASALİ, B. Caner, A. Bayram, E. Akyildiz, T. Evrensel
Objectives: Carcinoid tumors are rare neuroendocrine neoplasms of the lung. Although typical and atypical carcinoids have different clinical courses, most studies in the literature evaluate them together. Therefore, we aimed to investigate prognostic factors in patients with atypical carcinoids, excluding typical carcinoids. Methods: We included 32 patients with atypical carcinoids according to WHO 2021 criteria admitted to Uludag University Hospital. We retrospectively extracted the clinicopathological characteristics from electronic medical records. The log-rank tests were used to determine the prognostic factors on survival. Results: Median age was 57 (24-71) years. Pathological stages were as follows: stage I in 41%, II in 9%, III in 34%, and IV in 16%. Median Ki-67 index was 11% (1-50). Median follow-up time was 46.2 (0.7-184.2) months. 12-month and 48-month disease-free survival (DFS) rates were 92.3% and 79.2%, respectively. 12-month and 48-month overall survival (OS) rates were 93.8% and 86.2, respectively. Receiver operating characteristic curve analysis determined the Ki-67 cut-off as 12.5%. The log-rank test indicated that Ki-67 and stage were statistically significant prognostic factors for DFS and OS. The patients with a Ki-67 index lower than 12.5% had longer DFS and OS (p = 0.007 and p = 0.020, respectively). Conclusions: The Ki-67 index and 8th TNM staging have prognostic value on DFS and OS in patients with atypical carcinoids. Large-scale studies are needed to define the optimal cut-off value of Ki-67.
{"title":"Prognostic factors in atypical carcinoid tumors","authors":"A. Şahi̇n, E. Çubukçu, A. Deligönül, B. Ocak, H. Melek, Buket ERKAN OZMARASALİ, B. Caner, A. Bayram, E. Akyildiz, T. Evrensel","doi":"10.18621/eurj.1345267","DOIUrl":"https://doi.org/10.18621/eurj.1345267","url":null,"abstract":"Objectives: Carcinoid tumors are rare neuroendocrine neoplasms of the lung. Although typical and atypical carcinoids have different clinical courses, most studies in the literature evaluate them together. Therefore, we aimed to investigate prognostic factors in patients with atypical carcinoids, excluding typical carcinoids.\u0000Methods: We included 32 patients with atypical carcinoids according to WHO 2021 criteria admitted to Uludag University Hospital. We retrospectively extracted the clinicopathological characteristics from electronic medical records. The log-rank tests were used to determine the prognostic factors on survival. \u0000Results: Median age was 57 (24-71) years. Pathological stages were as follows: stage I in 41%, II in 9%, III in 34%, and IV in 16%. Median Ki-67 index was 11% (1-50). Median follow-up time was 46.2 (0.7-184.2) months. 12-month and 48-month disease-free survival (DFS) rates were 92.3% and 79.2%, respectively. 12-month and 48-month overall survival (OS) rates were 93.8% and 86.2, respectively. Receiver operating characteristic curve analysis determined the Ki-67 cut-off as 12.5%. The log-rank test indicated that Ki-67 and stage were statistically significant prognostic factors for DFS and OS. The patients with a Ki-67 index lower than 12.5% had longer DFS and OS (p = 0.007 and p = 0.020, respectively).\u0000Conclusions: The Ki-67 index and 8th TNM staging have prognostic value on DFS and OS in patients with atypical carcinoids. Large-scale studies are needed to define the optimal cut-off value of Ki-67.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"90 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90672854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: This study aimed to investigate the efficacy of intraoperative Superior Hypogastric Plexus Blocks (SHPBs) in managing postoperative pain following total abdominal hysterectomy, comparing pain scores and analgesic requirements between patients who received SHPBs and those who did not. Methods: A prospective, randomized, controlled trial was conducted on 70 female patients undergoing elective total abdominal hysterectomy. Patients were randomly assigned to either the SHPB group or the non-SHPB group. In the SHPB group, intraoperative SHPBs were administered after uterine removal. Postoperative pain scores were assessed using the Visual Analogue Scale (VAS) at various time points. Analgesic consumption and adverse effects were also recorded. Results: Patients in the SHPB group consistently exhibited lower pain scores compared to the non-SHPB group at various postoperative time intervals (p < 0.05). Initial analgesic requirements were significantly higher in the non-SHPB group, as was total analgesic consumption during the hospital stay (p < 0.05). No significant complications related to SHPB administration were observed. Conclusions: Intraoperative Superior Hypogastric Plexus Blocks demonstrated a potential benefit in reducing postoperative pain scores and analgesic consumption in patients undergoing total abdominal hysterectomy. These findings highlight the potential of SHPBs as an effective approach to enhance pain management in this surgical population, warranting further investigation and refinement of administration protocols.
{"title":"The role of intraoperative superior hypogastric plexus blocks in pain management for total abdominal hysterectomy: a comparative study","authors":"E. Gundogdu, Tuğba GÜL YILMAZ","doi":"10.18621/eurj.1340891","DOIUrl":"https://doi.org/10.18621/eurj.1340891","url":null,"abstract":"Objectives: This study aimed to investigate the efficacy of intraoperative Superior Hypogastric Plexus Blocks (SHPBs) in managing postoperative pain following total abdominal hysterectomy, comparing pain scores and analgesic requirements between patients who received SHPBs and those who did not. Methods: A prospective, randomized, controlled trial was conducted on 70 female patients undergoing elective total abdominal hysterectomy. Patients were randomly assigned to either the SHPB group or the non-SHPB group. In the SHPB group, intraoperative SHPBs were administered after uterine removal. Postoperative pain scores were assessed using the Visual Analogue Scale (VAS) at various time points. Analgesic consumption and adverse effects were also recorded. Results: Patients in the SHPB group consistently exhibited lower pain scores compared to the non-SHPB group at various postoperative time intervals (p < 0.05). Initial analgesic requirements were significantly higher in the non-SHPB group, as was total analgesic consumption during the hospital stay (p < 0.05). No significant complications related to SHPB administration were observed. Conclusions: Intraoperative Superior Hypogastric Plexus Blocks demonstrated a potential benefit in reducing postoperative pain scores and analgesic consumption in patients undergoing total abdominal hysterectomy. These findings highlight the potential of SHPBs as an effective approach to enhance pain management in this surgical population, warranting further investigation and refinement of administration protocols.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"73 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80457833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eryiğit Eren, Mehmet Tokac, Alaaddin Aydin, T. Sahin, Hikmet Bora Uslu, Selman Alkan, A. Dinckan
Objectives: Although there have been several advances in post-solid organ transplantation immunosuppression medications over the last two decades, the long-term survival of renal allografts did not significantly improve. Renal allograft biopsy is a helpful tool for determining the cause of graft dysfunction and adjusting patient management. Methods: Patients who received kidney transplantation and underwent allograft biopsy in Istinye University Hospital between January 2017 and January 2023 constituted the target population of this study. Demographic parameters, clinical data and biopsy indications, and histopathological assessment results of the patients were retrospectively analyzed. Results: Overall, 74 patients were included. The histopathology results included acute T-Cell mediated rejection (TCMR) (n = 15, 20%), tubular atrophy/chronic allograft nephropathy (IFTA) (n = 11, 15%), calcineurin inhibitor (CNI) toxicity (n = 2, 3%), chronic antibody-mediated rejection (ABMR) (n = 2, 3%), borderline pathology (n = 10, 13.5%), normal histology (n = 5, 6.5%), transplant glomerulopathy (TG) (n = 5, 6.5%), acute ABMR (n = 4, 5%), acute tubular necrosis (n = 7, 9%), polyomavirus nephropathy (n = 3, 4%) and non-specific changes (n = 10, 13.5%). The C4d was positive in 12% (n = 9) of the graft biopsies. In 73% (n = 54) of cases, the treatment strategy was changed based on biopsy results. Among all patients, 19 (25.6%) lost their grafts during follow-up. Conclusions: According to the histopathological analysis results, acute TCMR, IFTA, and borderline pathology were the most common causes of renal graft dysfunction. Renal allograft biopsy led to a remarkable change in treatment strategies in a significant number of cases.
{"title":"Histopathological diagnoses revealed by indication-based renal allograft biopsies: a retrospective analysis","authors":"Eryiğit Eren, Mehmet Tokac, Alaaddin Aydin, T. Sahin, Hikmet Bora Uslu, Selman Alkan, A. Dinckan","doi":"10.18621/eurj.1330877","DOIUrl":"https://doi.org/10.18621/eurj.1330877","url":null,"abstract":"Objectives: Although there have been several advances in post-solid organ transplantation immunosuppression medications over the last two decades, the long-term survival of renal allografts did not significantly improve. Renal allograft biopsy is a helpful tool for determining the cause of graft dysfunction and adjusting patient management.\u0000Methods: Patients who received kidney transplantation and underwent allograft biopsy in Istinye University Hospital between January 2017 and January 2023 constituted the target population of this study. Demographic parameters, clinical data and biopsy indications, and histopathological assessment results of the patients were retrospectively analyzed.\u0000Results: Overall, 74 patients were included. The histopathology results included acute T-Cell mediated rejection (TCMR) (n = 15, 20%), tubular atrophy/chronic allograft nephropathy (IFTA) (n = 11, 15%), calcineurin inhibitor (CNI) toxicity (n = 2, 3%), chronic antibody-mediated rejection (ABMR) (n = 2, 3%), borderline pathology (n = 10, 13.5%), normal histology (n = 5, 6.5%), transplant glomerulopathy (TG) (n = 5, 6.5%), acute ABMR (n = 4, 5%), acute tubular necrosis (n = 7, 9%), polyomavirus nephropathy (n = 3, 4%) and non-specific changes (n = 10, 13.5%). The C4d was positive in 12% (n = 9) of the graft biopsies. In 73% (n = 54) of cases, the treatment strategy was changed based on biopsy results. Among all patients, 19 (25.6%) lost their grafts during follow-up.\u0000Conclusions: According to the histopathological analysis results, acute TCMR, IFTA, and borderline pathology were the most common causes of renal graft dysfunction. Renal allograft biopsy led to a remarkable change in treatment strategies in a significant number of cases.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"2013 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87906653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: Hyponatremia is known to increase mortality and morbidity in adult patients. However, the significance of hyponatremia in critically ill pediatric patients is unknown, unlike in adults. We tried to determine the prevalance of hyponatremia in critically ill children and whether the severity of hyponatremia contributes to hospital stay and mortality. Methods: The results of 190 patients who met the inclusion criteria and were admitted to the pediatric intensive care unit between April 2014 and April 2017 were analyzed. Results: Eighty-six (45.3%) patients developed hyponatremia at the time of hospitalization, and Hospital‑Acquired Hyponatremia (HAH) developed in 46 (24.2%) patients during the hospitalization. Fifty-eight (30.5%) patients were normonatremic. The patients in the HAH group were significantly more septic (p = 0.015). The duration of intensive care hospitalization was significantly longer in the HAH group (p < 0.001) and significantly less in the normonatremic group (p = 0.008). Total mortality was 41% (n = 78). There was no difference between the groups regarding mortality (p = 0.4). However, the degree of hyponatremia was associated with mortality. Mortality was 24.1% in mildly hyponatremic patients, 45.6% in moderate patients, and 58.8% in severe patients (OR: 2.636, 95% CI: 1.189-5.842; OR: 4.490, 95% CI:1.439-14.008, p = 0.01). We discovered that as hyponatremia severity increased, so did the length of stay in the intensive care unit, the need for invasive ventilation, and the need for vasoactive drugs (p = 0.009, p = 0.018, and p = 0.006, respectively). Conclusions: Unlike adults, the prognostic value of hyponatremia in terms of mortality has not been determined in critically ill children. However, as the severity of hyponatremia increased, it was seen that the length of stay in the intensive care unit and mortality increased.
{"title":"The severity of hyponatremia worsens the outcome in pediatric intensive care patients","authors":"A. Oto, Seher Erdoğan, M. Boşnak","doi":"10.18621/eurj.1342084","DOIUrl":"https://doi.org/10.18621/eurj.1342084","url":null,"abstract":"Objectives: Hyponatremia is known to increase mortality and morbidity in adult patients. However, the significance of hyponatremia in critically ill pediatric patients is unknown, unlike in adults. We tried to determine the prevalance of hyponatremia in critically ill children and whether the severity of hyponatremia contributes to hospital stay and mortality. \u0000Methods: The results of 190 patients who met the inclusion criteria and were admitted to the pediatric intensive care unit between April 2014 and April 2017 were analyzed. \u0000Results: Eighty-six (45.3%) patients developed hyponatremia at the time of hospitalization, and Hospital‑Acquired Hyponatremia (HAH) developed in 46 (24.2%) patients during the hospitalization. Fifty-eight (30.5%) patients were normonatremic. The patients in the HAH group were significantly more septic (p = 0.015). The duration of intensive care hospitalization was significantly longer in the HAH group (p < 0.001) and significantly less in the normonatremic group (p = 0.008). Total mortality was 41% (n = 78). There was no difference between the groups regarding mortality (p = 0.4). However, the degree of hyponatremia was associated with mortality. Mortality was 24.1% in mildly hyponatremic patients, 45.6% in moderate patients, and 58.8% in severe patients (OR: 2.636, 95% CI: 1.189-5.842; OR: 4.490, 95% CI:1.439-14.008, p = 0.01). We discovered that as hyponatremia severity increased, so did the length of stay in the intensive care unit, the need for invasive ventilation, and the need for vasoactive drugs (p = 0.009, p = 0.018, and p = 0.006, respectively).\u0000Conclusions: Unlike adults, the prognostic value of hyponatremia in terms of mortality has not been determined in critically ill children. However, as the severity of hyponatremia increased, it was seen that the length of stay in the intensive care unit and mortality increased.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81577358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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