Objectives: We aimed to evaluate patients using ibrutinib for the treatment of chronic lymphocytic leukemia (CLL) and relapsed/refractory mantle-cell lymphoma (MCL), focusing on high-risk subgroups, predictors of efficacy, response levels, and safety profile. Methods: This retrospective cohort study included adult patients diagnosed with CLL and relapsed/refractory MCL who were started on ibrutinib as a single-agent between May 2015 and December 2021 in Bursa Uludag University, Department of Hematology. Results: Of the 45 patients (23 CLL, 22 MCL) started on ibrutinib, the median age was 65 (range: 48-86) years, and 66.7% were male. Del(17p) was present in 47.8% of CLL patients; there was no remarkable difference between del(17p) status and the rates of achieving CR. The median follow-up with ibrutinib treatment in CLL patients was 13.3 (range: 0.3-77.8) months. In univariate analysis, progression-free survival (PFS) and overall survival (OS) were associated with the advanced Eastern Cooperative Oncology Group (ECOG) score (p = 0.003 and p = 0.004, respectively), and > 2 lines treatment regimens before ibrutinib (p = 0.016 and p = 0.050, respectively). In multivariate analysis, the ECOG performance status remained significant for OS. The median use of ibrutinib for MCL patients was 6 (range: 1-48) months, and the proportion of patients who achieved CR was 27.3%. In the univariate analysis of MCL patients, the ECOG performance status for PFS and OS was statistically significant (p = 0.045 and p = 0.016, respectively). Patients' most common non-hematological adverse events were pneumonia and urinary tract infection. Conclusions: Our investigation of patient outcomes treated outside clinical trials confirms ibrutinib's sufficient efficacy and safety profile in CLL and relapsed/refractory MCL.
{"title":"Efficacy and safety outcomes of single-agent ibrutinib therapy in chronic lymphocytic leukemia and relapsed/refractory mantle-cell lymphoma","authors":"İbrahim Ethem PINAR, Vildan OZKOCAMAN","doi":"10.18621/eurj.1359362","DOIUrl":"https://doi.org/10.18621/eurj.1359362","url":null,"abstract":"Objectives: We aimed to evaluate patients using ibrutinib for the treatment of chronic lymphocytic leukemia (CLL) and relapsed/refractory mantle-cell lymphoma (MCL), focusing on high-risk subgroups, predictors of efficacy, response levels, and safety profile. Methods: This retrospective cohort study included adult patients diagnosed with CLL and relapsed/refractory MCL who were started on ibrutinib as a single-agent between May 2015 and December 2021 in Bursa Uludag University, Department of Hematology. Results: Of the 45 patients (23 CLL, 22 MCL) started on ibrutinib, the median age was 65 (range: 48-86) years, and 66.7% were male. Del(17p) was present in 47.8% of CLL patients; there was no remarkable difference between del(17p) status and the rates of achieving CR. The median follow-up with ibrutinib treatment in CLL patients was 13.3 (range: 0.3-77.8) months. In univariate analysis, progression-free survival (PFS) and overall survival (OS) were associated with the advanced Eastern Cooperative Oncology Group (ECOG) score (p = 0.003 and p = 0.004, respectively), and > 2 lines treatment regimens before ibrutinib (p = 0.016 and p = 0.050, respectively). In multivariate analysis, the ECOG performance status remained significant for OS. The median use of ibrutinib for MCL patients was 6 (range: 1-48) months, and the proportion of patients who achieved CR was 27.3%. In the univariate analysis of MCL patients, the ECOG performance status for PFS and OS was statistically significant (p = 0.045 and p = 0.016, respectively). Patients' most common non-hematological adverse events were pneumonia and urinary tract infection. Conclusions: Our investigation of patient outcomes treated outside clinical trials confirms ibrutinib's sufficient efficacy and safety profile in CLL and relapsed/refractory MCL.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"18 6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135268388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: Lower extremity lymphedema due to secondary causes is a lifelong complication that can be encountered. Its treatment is essential, because it has significant impact on quality of life and daily living activities related to lower extremity involvement. This research aims to compare the effects of Manual Lymphatic Drainage Massage (MLD) and Negative Pressure Massage Therapy (NPMT) treatments in order to provide maximum benefit to patients. Methods: This prospective, randomized study included 30 patients with lower extremity lymphedema due to secondary causes. Patients, randomized using computer software, were divided into two groups. The first group (n =15) received 45 minutes, 15 sessions of MLD, while the second group (n =15) received 45 minutes of 15 sessions of NPMT using the LymphaTouch device. Compression bandaging was applied to both groups and self-drainage training was given to all patients. The circumference of the extremity at 6 reference points were measured and their pain and discomfort assessed by the Visual Analogue Scale (VAS) were recorded before and after treatment. Changes within the groups and between the groups were compared using the SPSS statistical program. Results: Statistically significant improvement was observed in all parameters in both treatment groups. The decrease in VAS pain and VAS discomfort scores (p < 0.05 and p < 0.01; respectively), circumference measurement of the extremity (p < 0.01) was statistically greater in the NPMT group compared to the MLD group. Conclusions: In conclusion, NPMT appears to be a beneficial non-invasive treatment method for reducing extremity volumes and decreasing subjective pain and discomfort in lymphedema patients.
{"title":"Comparison of manual lymphatic drainage massage and negative pressure massage therapy efficacy in lymphedema patients: a randomized controlled study","authors":"Sedef ERSOY, Nur KESİKTAŞ, Büşra ŞİRİN, Nazlı Derya BUĞDAYCI, Halime KİBAR, Nurdan PAKER","doi":"10.18621/eurj.1354942","DOIUrl":"https://doi.org/10.18621/eurj.1354942","url":null,"abstract":"Objectives: Lower extremity lymphedema due to secondary causes is a lifelong complication that can be encountered. Its treatment is essential, because it has significant impact on quality of life and daily living activities related to lower extremity involvement. This research aims to compare the effects of Manual Lymphatic Drainage Massage (MLD) and Negative Pressure Massage Therapy (NPMT) treatments in order to provide maximum benefit to patients. Methods: This prospective, randomized study included 30 patients with lower extremity lymphedema due to secondary causes. Patients, randomized using computer software, were divided into two groups. The first group (n =15) received 45 minutes, 15 sessions of MLD, while the second group (n =15) received 45 minutes of 15 sessions of NPMT using the LymphaTouch device. Compression bandaging was applied to both groups and self-drainage training was given to all patients. The circumference of the extremity at 6 reference points were measured and their pain and discomfort assessed by the Visual Analogue Scale (VAS) were recorded before and after treatment. Changes within the groups and between the groups were compared using the SPSS statistical program. Results: Statistically significant improvement was observed in all parameters in both treatment groups. The decrease in VAS pain and VAS discomfort scores (p &lt; 0.05 and p &lt; 0.01; respectively), circumference measurement of the extremity (p &lt; 0.01) was statistically greater in the NPMT group compared to the MLD group. Conclusions: In conclusion, NPMT appears to be a beneficial non-invasive treatment method for reducing extremity volumes and decreasing subjective pain and discomfort in lymphedema patients.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136080066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ewing sarcoma (ES) is a malignant soft tissue tumor that consists of undifferentiated neuroectodermal cells. The anatomical sites of ES are commonly the pelvis and long bones. Metastasis is the cause of the most prevalent pulmonary ES. The primary lung origin of ES is extremely uncommon. Here, we report a rare case of primary pulmonary ES diagnosed from cytology and biopsy material. A chest X-ray revealed a lesion with a 9 × 7.5 cm diameter in the pericardiac area of the right lung. Clinical and radiological examinations (computed tomography and positron emission tomography) demonstrated that the lesion was a primary lesion. No distant metastasis was detected. Bronchoscopy-guided fine-needle aspiration and cytological analysis of the lesion revealed uniformly shaped small round cell morphology. Immunohistochemistry performed on the cell block produced positive results for CD99 and FLI-1. These immunohistochemical findings support the ES diagnosis.
{"title":"Primary pulmonary Ewing sarcoma: a rare case report","authors":"Remzi ARSLAN, Harika Derya TAMER, Ayşe Nur TEMTEK","doi":"10.18621/eurj.1336479","DOIUrl":"https://doi.org/10.18621/eurj.1336479","url":null,"abstract":"Ewing sarcoma (ES) is a malignant soft tissue tumor that consists of undifferentiated neuroectodermal cells. The anatomical sites of ES are commonly the pelvis and long bones. Metastasis is the cause of the most prevalent pulmonary ES. The primary lung origin of ES is extremely uncommon. Here, we report a rare case of primary pulmonary ES diagnosed from cytology and biopsy material. A chest X-ray revealed a lesion with a 9 × 7.5 cm diameter in the pericardiac area of the right lung. Clinical and radiological examinations (computed tomography and positron emission tomography) demonstrated that the lesion was a primary lesion. No distant metastasis was detected. Bronchoscopy-guided fine-needle aspiration and cytological analysis of the lesion revealed uniformly shaped small round cell morphology. Immunohistochemistry performed on the cell block produced positive results for CD99 and FLI-1. These immunohistochemical findings support the ES diagnosis.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"93 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135093327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alper TÜRKKAN, Pınar ESER OCAK, Oğuz ALTUNYUVA, Buket SÖNMEZ, Rifat ÖZPAR, Ahmet BEKAR
Objectives: Aquaductal web (AW) is a special form of aqueductal stenosis with similar clinical presentation with idiopathic normal pressure hydrocephalus (iNPH). iNPH is indeed a communicating hydrocephalus syndrome whereas AW is a noncommunicating subtype. Here, we aimed to investigate the similarities and differences between these two different chronic hydrocephalus syndromes in terms of clinical signs and symptoms, response to shunt treatment and postoperative complications. Methods: Forty-one patients who underwent shunt operation with the diagnosis of iNPH or AW at our clinic between January 2010-May 2019 were retrospectively analyzed. Patients were evaluated by age, gender, clinical sign and symptoms, comorbidities, intraoperative and postoperative complications, and early and late postoperative outpatient follow-up findings. Results: Twenty-six patients were classified as iNPH group and 15 patients as AW group. Patients in the AW group were significantly younger (45.5 ± 15.6 years vs. 60.3 ± 15.4 years) than the iNPH group (p = 0.006). There was no statistical difference between the groups in terms of subdural effusion formation, need for shunt revision (p = 1.000). Chronic hydrocephalus symptoms regressed in 23 (88.5%) patients in the NPH group, and at least one of them improved. symptoms. This rate was 66.7% (n = 10) in the AW group. Both groups showed similar clinical improvement with VPS (p = 0.1169). Conclusions: The placement of ventriculoperitoenal shunt is widely used in the treatment of iNPH. As iNPH and AW has clinical similarities despite the discrepancies between underlying pathophysiological mechanisms and both clinical entities respond similarly to shunt treatment we advocate VPS surgery in the management of AW as well.
{"title":"Comparative retrospective analysis of patients with idiopathic normal pressure hydrocephalus and aqueductal web-related aqueductal stenosis.","authors":"Alper TÜRKKAN, Pınar ESER OCAK, Oğuz ALTUNYUVA, Buket SÖNMEZ, Rifat ÖZPAR, Ahmet BEKAR","doi":"10.18621/eurj.1347626","DOIUrl":"https://doi.org/10.18621/eurj.1347626","url":null,"abstract":"Objectives: Aquaductal web (AW) is a special form of aqueductal stenosis with similar clinical presentation with idiopathic normal pressure hydrocephalus (iNPH). iNPH is indeed a communicating hydrocephalus syndrome whereas AW is a noncommunicating subtype. Here, we aimed to investigate the similarities and differences between these two different chronic hydrocephalus syndromes in terms of clinical signs and symptoms, response to shunt treatment and postoperative complications. Methods: Forty-one patients who underwent shunt operation with the diagnosis of iNPH or AW at our clinic between January 2010-May 2019 were retrospectively analyzed. Patients were evaluated by age, gender, clinical sign and symptoms, comorbidities, intraoperative and postoperative complications, and early and late postoperative outpatient follow-up findings. Results: Twenty-six patients were classified as iNPH group and 15 patients as AW group. Patients in the AW group were significantly younger (45.5 ± 15.6 years vs. 60.3 ± 15.4 years) than the iNPH group (p = 0.006). There was no statistical difference between the groups in terms of subdural effusion formation, need for shunt revision (p = 1.000). Chronic hydrocephalus symptoms regressed in 23 (88.5%) patients in the NPH group, and at least one of them improved. symptoms. This rate was 66.7% (n = 10) in the AW group. Both groups showed similar clinical improvement with VPS (p = 0.1169). Conclusions: The placement of ventriculoperitoenal shunt is widely used in the treatment of iNPH. As iNPH and AW has clinical similarities despite the discrepancies between underlying pathophysiological mechanisms and both clinical entities respond similarly to shunt treatment we advocate VPS surgery in the management of AW as well.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135092836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: Sodium measurement in spot urine provides important information about the adequacy of the initial dose in acute heart failure (AHF) patients using intravenous diuretic (IV) and makes a guiding contribution to the titration decision. It is not clear whether spot urine sodium measurement has the same clinical value as the effect of sodium-glucose cotransporter 2 inhibitor (SGLT2i) drugs on urinary electrolytes. Our aim in our study is to investigate the clinical value of sodium examination in spot urine in AHF patients while using SGLT2i. Methods: Our study was conducted retrospectively and single-centered. AHF patients, administered IV diuretics were included in the study. Patients who were using and were not using SGLT2i were examined in two groups. The 2nd and 6th-hour sodium values in spot urine were measured. Results: Patients using SGLT2i (n = 46) and not using it (n = 54) were included. The mean age was 69.91 ± 11.84 years and 47% were female. The standard deviation value for the sodium in spot urine in patients using SGLT2i was clearly high and its distribution was significantly higher. A weak correlation was found between the sodium value in spot urine and the 24-hour urine volume in this group. Hospitalization history within 1 month after discharge was found to be 39% in the group using SGLT2i, and 51% in the group that did not use it, and this difference was statistically significant. Conclusions: The measurement of sodium in spot urine does not seem to have the same clinical value in HF patients using SGLT2i. Its correlation with urine volume is also decreasing in this group.
{"title":"Evaluation of the clinical value of sodium examination in spot urine in patients presenting with acute heart failure while using SGLT2i – ‘‘SPOT HF STUDY’’","authors":"Onur ASLAN, Emre Emrah DEMİRCİ","doi":"10.18621/eurj.1349473","DOIUrl":"https://doi.org/10.18621/eurj.1349473","url":null,"abstract":"Objectives: Sodium measurement in spot urine provides important information about the adequacy of the initial dose in acute heart failure (AHF) patients using intravenous diuretic (IV) and makes a guiding contribution to the titration decision. It is not clear whether spot urine sodium measurement has the same clinical value as the effect of sodium-glucose cotransporter 2 inhibitor (SGLT2i) drugs on urinary electrolytes. Our aim in our study is to investigate the clinical value of sodium examination in spot urine in AHF patients while using SGLT2i. Methods: Our study was conducted retrospectively and single-centered. AHF patients, administered IV diuretics were included in the study. Patients who were using and were not using SGLT2i were examined in two groups. The 2nd and 6th-hour sodium values in spot urine were measured. Results: Patients using SGLT2i (n = 46) and not using it (n = 54) were included. The mean age was 69.91 ± 11.84 years and 47% were female. The standard deviation value for the sodium in spot urine in patients using SGLT2i was clearly high and its distribution was significantly higher. A weak correlation was found between the sodium value in spot urine and the 24-hour urine volume in this group. Hospitalization history within 1 month after discharge was found to be 39% in the group using SGLT2i, and 51% in the group that did not use it, and this difference was statistically significant. Conclusions: The measurement of sodium in spot urine does not seem to have the same clinical value in HF patients using SGLT2i. Its correlation with urine volume is also decreasing in this group.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134974971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Murat ŞEN, Tuncay YILMAZLAR, Deniz SIĞIRLI, Özgen IŞIK
Objectives: The complete mesocolic excision (CME) technique has been described to improve the surgical outcomes of colon cancer. Collecting more lymph nodes is one of the goals of CME. In our study, indocyanine green (ICG) injection was applied to the anterior and posterior walls at certain levels of the right colon. The aim of this study is to determine the impact of lymphangiography in right colon cancer surgery. Methods: The data of patients were analyzed who underwent colectomy surgery between 1.1.2018-1.1.2022 and using our mapping technique. A case-match study was performed at a ratio of 1:2 (Study group [group S; n =10], Control group [group C; n = 20]). Case-matched criteria were age +/-10, T stage +/-1, and tumor location. Results: There were no differences in terms of age, the American Society of Anesthesiologists score, tumor location, tumor T and N stages, and pathological markers affecting prognosis between the groups. Although 10% of intraoperative complications were seen in group C, it was not statistically significant (p = 0.540). After lymphangiography, lymph nodes containing ICG were detected in the resection site and these lymph nodes were sent to pathology in separate containers. Considering the number of lymph nodes sent separately, it was determined that significantly more lymph nodes were sent in the group S (p = 0.001). Conclusions: We have shown that the ICG mapping can be applied safely in the surgical treatment of right colon cancer.
{"title":"Early results of fluorescence lymphatic mapping for right colon cancer: a case-matched study","authors":"Murat ŞEN, Tuncay YILMAZLAR, Deniz SIĞIRLI, Özgen IŞIK","doi":"10.18621/eurj.1342055","DOIUrl":"https://doi.org/10.18621/eurj.1342055","url":null,"abstract":"Objectives: The complete mesocolic excision (CME) technique has been described to improve the surgical outcomes of colon cancer. Collecting more lymph nodes is one of the goals of CME. In our study, indocyanine green (ICG) injection was applied to the anterior and posterior walls at certain levels of the right colon. The aim of this study is to determine the impact of lymphangiography in right colon cancer surgery. Methods: The data of patients were analyzed who underwent colectomy surgery between 1.1.2018-1.1.2022 and using our mapping technique. A case-match study was performed at a ratio of 1:2 (Study group [group S; n =10], Control group [group C; n = 20]). Case-matched criteria were age +/-10, T stage +/-1, and tumor location. Results: There were no differences in terms of age, the American Society of Anesthesiologists score, tumor location, tumor T and N stages, and pathological markers affecting prognosis between the groups. Although 10% of intraoperative complications were seen in group C, it was not statistically significant (p = 0.540). After lymphangiography, lymph nodes containing ICG were detected in the resection site and these lymph nodes were sent to pathology in separate containers. Considering the number of lymph nodes sent separately, it was determined that significantly more lymph nodes were sent in the group S (p = 0.001). Conclusions: We have shown that the ICG mapping can be applied safely in the surgical treatment of right colon cancer.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134961094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Halil İbrahim TIRAŞ, Yakup DÜLGEROĞLU, Çetin AYDIN
Objectives: Epithelial ovarian cancer (EOC) is the most common histologic type among ovarian cancers. It is usually diagnosed at an advanced stage and the prognosis worsens. The aim of our study was to investigate the predictive value of serum platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR), which are systemic inflammatory response markers in EOC stages. Methods: In this study, 140 patients diagnosed with primary EOC in İzmir Katip Çelebi University Atatürk Training and Research Hospital Gynecology and Obstetrics Clinic between 01.01.2012-01.07.2019 were included. The cases were staged using the FIGO 2014 Ovarian Cancer Staging system. Whether the PLR and NLR values were different between the stages were analyzed with appropriate statistical analysis methods. Results: A total of 140 patients, 54 were in the early stage (Stage I: 47; Stage II: 7) and 86 were in the advanced stage (Stage III: 73; Stage IV: 13). The PLR and NLR values differed between the four stages (p = 0.003 and p = 0.032, respectively). The PLR value was different between the early and advanced stages (p = 0.033), the AUC value was 0.607, the optimum cut-off was 220, the sensitivity was 47%, and the specificity was 81% in the early and advanced stage discrimination. Accordingly, the Odds ratio of PLR for advanced EOC was 3.82 (95% CI: 1.70-8.57, p = 0.0011). Conclusions: The NLR and PLR values were found to have a prognostic value in the discrimination of EOC stages. It has been determined that PLR value may play a predictive role in advanced EOC before surgery.
目的:上皮性卵巢癌(EOC)是卵巢癌中最常见的组织学类型。它通常在晚期被诊断出来，预后恶化。我们的研究目的是探讨血清血小板与淋巴细胞比率(PLR)和中性粒细胞与淋巴细胞比率(NLR)的预测价值，这是EOC分期的全身炎症反应指标。方法:选取İzmir Katip Çelebi University atatat rk Training and Research Hospital妇产科门诊2012年1月1日至2019年1月7日期间诊断为原发性EOC的140例患者。采用FIGO 2014卵巢癌分期系统对病例进行分期。采用相应的统计分析方法分析各阶段间PLR和NLR值是否存在差异。结果:共140例患者，早期54例(I期47例;II期:7例)，晚期86例(III期:73例;第四阶段:13)。PLR和NLR值在4个阶段之间存在差异(p = 0.003和p = 0.032)。早期和晚期的PLR值存在差异(p = 0.033)， AUC值为0.607，最佳临界值为220，早期和晚期鉴别的敏感性为47%，特异性为81%。因此，晚期EOC的PLR优势比为3.82 (95% CI: 1.70-8.57, p = 0.0011)。结论:NLR和PLR值对鉴别EOC分期具有预测价值。已经确定，术前PLR值可能对晚期EOC有预测作用。
{"title":"Comparison of platelet-to-lymphocyte and neutrophil-to-lymphocyte ratios with epithelial ovarian cancer stages","authors":"Halil İbrahim TIRAŞ, Yakup DÜLGEROĞLU, Çetin AYDIN","doi":"10.18621/eurj.1308975","DOIUrl":"https://doi.org/10.18621/eurj.1308975","url":null,"abstract":"Objectives: Epithelial ovarian cancer (EOC) is the most common histologic type among ovarian cancers. It is usually diagnosed at an advanced stage and the prognosis worsens. The aim of our study was to investigate the predictive value of serum platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR), which are systemic inflammatory response markers in EOC stages. Methods: In this study, 140 patients diagnosed with primary EOC in İzmir Katip Çelebi University Atatürk Training and Research Hospital Gynecology and Obstetrics Clinic between 01.01.2012-01.07.2019 were included. The cases were staged using the FIGO 2014 Ovarian Cancer Staging system. Whether the PLR and NLR values were different between the stages were analyzed with appropriate statistical analysis methods. Results: A total of 140 patients, 54 were in the early stage (Stage I: 47; Stage II: 7) and 86 were in the advanced stage (Stage III: 73; Stage IV: 13). The PLR and NLR values differed between the four stages (p = 0.003 and p = 0.032, respectively). The PLR value was different between the early and advanced stages (p = 0.033), the AUC value was 0.607, the optimum cut-off was 220, the sensitivity was 47%, and the specificity was 81% in the early and advanced stage discrimination. Accordingly, the Odds ratio of PLR for advanced EOC was 3.82 (95% CI: 1.70-8.57, p = 0.0011). Conclusions: The NLR and PLR values were found to have a prognostic value in the discrimination of EOC stages. It has been determined that PLR value may play a predictive role in advanced EOC before surgery.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135063751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: Breast self-examination (BSE) is very important to early detect breast cancer in women in addition to imaging methods. The easiest way to access information concerning how to perform this examination is undoubtedly the internet, and the most popular platform is YouTube. However, the most important disadvantage of this massive platform is the risk of spreading false information since it cannot be audited. This study aimed to evaluate Turkish videos on BSE on YouTube in terms of quality and content. Methods: On January 17, 2022, a search was conducted on YouTube using the keyword “breast self-examination”, and the first 210 videos presented on the first five pages were obtained. After applying the study criteria, 156 were included in the sample and evaluated by two general surgeons in terms of educational value, content, and upload source. Results: Of the 156 videos, 23 were categorized as useful (14.7%) and 133 as misleading (85.3%). When examined according to the upload source group, universities/professional organizations/non-profit physicians/physicians had the highest rate of misleading videos (96.9%), while stand-alone health information websites had the highest rate of useful videos (24%). There was no significant difference between the upload sources in terms of video length, number of views, content score, or quality score. Conclusions: The number of useful Turkish videos on BSE is very low. Our results indicate the need for more educational and useful videos to be produced, especially by healthcare professionals who use the YouTube platform.
{"title":"Evaluation of Turkish videos about breast self-examination on YouTube","authors":"Mehmet Eşref ULUTAŞ, Eray BALCI","doi":"10.18621/eurj.1329729","DOIUrl":"https://doi.org/10.18621/eurj.1329729","url":null,"abstract":"Objectives: Breast self-examination (BSE) is very important to early detect breast cancer in women in addition to imaging methods. The easiest way to access information concerning how to perform this examination is undoubtedly the internet, and the most popular platform is YouTube. However, the most important disadvantage of this massive platform is the risk of spreading false information since it cannot be audited. This study aimed to evaluate Turkish videos on BSE on YouTube in terms of quality and content. Methods: On January 17, 2022, a search was conducted on YouTube using the keyword “breast self-examination”, and the first 210 videos presented on the first five pages were obtained. After applying the study criteria, 156 were included in the sample and evaluated by two general surgeons in terms of educational value, content, and upload source. Results: Of the 156 videos, 23 were categorized as useful (14.7%) and 133 as misleading (85.3%). When examined according to the upload source group, universities/professional organizations/non-profit physicians/physicians had the highest rate of misleading videos (96.9%), while stand-alone health information websites had the highest rate of useful videos (24%). There was no significant difference between the upload sources in terms of video length, number of views, content score, or quality score. Conclusions: The number of useful Turkish videos on BSE is very low. Our results indicate the need for more educational and useful videos to be produced, especially by healthcare professionals who use the YouTube platform.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135015586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: Sarcopenia is associated with atherosclerosis, vascular dysfunction, and poor in-hospital prognosis in the general COVID-19 population. Coronary artery disease (CAD) is also associated with poor prognosis in patients with COVID-19, however, the influencing factors in this association have not yet been fully documented. This study aimed to evaluate the effect of sarcopenia on both in-hospital acute-term and mid-term follow-up clinical results in patients with CAD and COVID-19.
Methods: The study population was selected from the general COVID-19 population. It consisted of 50 patients with CAD (group I) and 80 age- and gender-matched patients without CAD (group II). In-hospital acute term endpoints were determined as intensive care unit (ICU) admission, intubation, mortality, and its combination. Mid-term follow-up was also made for three-month. Sarcopenia was assessed by indexed skeletal muscle mass at T12 vertebrae level (T12-SMI) on initial chest computed tomography. Multivariable logistic regression analysis was used to detect independently related factors to endpoints.
Results: Group I had more severe COVID-19 disease and a higher rate of hospitalization, ICU admission, intubation as well as mortality compared to group II in acute-term. T12-SMI was lower and sarcopenia was more frequent in group I than in group II. During the three-month mid-term follow-up period, no additional adverse results occurred in both groups. In multivariate regression analysis; sarcopenia was independently related to in-hospital combined endpoint.
Conclusions: Sarcopenia is associated with in-hospital combined endpoint in patients with CAD during acute-term of COVID-19. However, it has no effect on three-month mid-term follow-up.
{"title":"Effects of sarcopenia on in-hospital results and mid-term follow-up in patients with coronary artery disease and COVID-19","authors":"Merve ERKAN, İsmet ZENGİN","doi":"10.18621/eurj.1316381","DOIUrl":"https://doi.org/10.18621/eurj.1316381","url":null,"abstract":"Objectives: Sarcopenia is associated with atherosclerosis, vascular dysfunction, and poor in-hospital prognosis in the general COVID-19 population. Coronary artery disease (CAD) is also associated with poor prognosis in patients with COVID-19, however, the influencing factors in this association have not yet been fully documented. This study aimed to evaluate the effect of sarcopenia on both in-hospital acute-term and mid-term follow-up clinical results in patients with CAD and COVID-19.
 Methods: The study population was selected from the general COVID-19 population. It consisted of 50 patients with CAD (group I) and 80 age- and gender-matched patients without CAD (group II). In-hospital acute term endpoints were determined as intensive care unit (ICU) admission, intubation, mortality, and its combination. Mid-term follow-up was also made for three-month. Sarcopenia was assessed by indexed skeletal muscle mass at T12 vertebrae level (T12-SMI) on initial chest computed tomography. Multivariable logistic regression analysis was used to detect independently related factors to endpoints.
 Results: Group I had more severe COVID-19 disease and a higher rate of hospitalization, ICU admission, intubation as well as mortality compared to group II in acute-term. T12-SMI was lower and sarcopenia was more frequent in group I than in group II. During the three-month mid-term follow-up period, no additional adverse results occurred in both groups. In multivariate regression analysis; sarcopenia was independently related to in-hospital combined endpoint. 
 Conclusions: Sarcopenia is associated with in-hospital combined endpoint in patients with CAD during acute-term of COVID-19. However, it has no effect on three-month mid-term follow-up.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135741349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: The aim of this investigation was to undertake a thorough bibliometric analysis of publications between 1991 and 2022 to scrutinize and comprehend the research landscape of osteoarticular brucellosis, a zoonotic infection that affects bones and joints. Methods: We scrutinized the distribution of publications by various criteria, including country, institution, author, and journal. Furthermore, we executed citation analysis, established collaboration networks, and performed keyword co-occurrence analysis. Results: Our examination discovered 432 documents on this topic indexed in the Web of Science database, with a noticeable surge in publications over time. Turkey, the United States, and Iran were the leading nations in terms of research output. The University of Buenos Aires emerged as the most productive institution. The primary research areas were General Internal Medicine, Infectious Diseases, and Rheumatology. The primary beneficiary of this research was Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT). Conclusions: This study furnishes valuable insights into worldwide research endeavors on osteoarticular brucellosis. These insights can steer future research directions, emphasizing the necessity for sustained collaboration and funding support to tackle this significant public health issue.
目的:本研究的目的是对1991年至2022年间的出版物进行全面的文献计量学分析，以审查和理解骨关节布鲁氏菌病(一种影响骨骼和关节的人畜共患感染)的研究概况。方法:我们根据不同的标准，包括国家、机构、作者和期刊，仔细检查出版物的分布。此外，我们进行了引文分析，建立了协作网络，并进行了关键词共现分析。结果:我们在Web of Science数据库中发现了432篇关于这个主题的文档，随着时间的推移，出版物数量明显增加。土耳其、美国和伊朗是研究产出方面的主要国家。布宜诺斯艾利斯大学成为最具生产力的机构。主要研究领域为普通内科、感染性疾病和风湿病学。这项研究的主要受益者是国家机构Promoción Científica y Tecnológica (ANPCyT)。结论:本研究为全球骨关节布鲁氏菌病的研究提供了有价值的见解。这些见解可以指导未来的研究方向，强调需要持续的合作和资金支持来解决这一重大的公共卫生问题。
{"title":"Bibliometric analysis of publications on osteoarticular brucellosis","authors":"Cihan SEMET","doi":"10.18621/eurj.1295895","DOIUrl":"https://doi.org/10.18621/eurj.1295895","url":null,"abstract":"Objectives: The aim of this investigation was to undertake a thorough bibliometric analysis of publications between 1991 and 2022 to scrutinize and comprehend the research landscape of osteoarticular brucellosis, a zoonotic infection that affects bones and joints. Methods: We scrutinized the distribution of publications by various criteria, including country, institution, author, and journal. Furthermore, we executed citation analysis, established collaboration networks, and performed keyword co-occurrence analysis. Results: Our examination discovered 432 documents on this topic indexed in the Web of Science database, with a noticeable surge in publications over time. Turkey, the United States, and Iran were the leading nations in terms of research output. The University of Buenos Aires emerged as the most productive institution. The primary research areas were General Internal Medicine, Infectious Diseases, and Rheumatology. The primary beneficiary of this research was Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT). Conclusions: This study furnishes valuable insights into worldwide research endeavors on osteoarticular brucellosis. These insights can steer future research directions, emphasizing the necessity for sustained collaboration and funding support to tackle this significant public health issue.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135982510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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