Objectives: Frailty is a significant clinical syndrome characterized by greater susceptibility to stressors due to the dysfunction of multiple organ systems, which increases in prevalence with age. This study was performed to investigate relations between frailty and nutritional parameters in patients with chronic kidney disease (CKD). Methods: This cross-sectional study involved 100 CKD patients aged 50 years or older. Frailty was assessed using the Edmonton Frailty Scale (EFS) and Fried’s Frailty Scale (FFS). The patients nutritional status was assessed using the Mini Nutritional Assessment (MNA) and the routine laboratory tests. Results: The study included 100 patients, consisting of 41 females and 59 males. The mean age of the participants was 65.3±9.3 years. The median glomerular filtration rate (GFR) of the patients was 23 mL/min/1.73 m2) (min: 3-max: 65). According to the MNA, 15 patients had normal nutritional status, 63 were at risk of malnutrition, and 22 were malnourished. According to the EFS score, four patients were categorized as not frail, 11 as vulnerable, 25 with mild frailty, 21 with moderate frailty, and 39 with severe frailty. According to the FFS score, six patients were non-frail, 30 were classified as pre-frail, and 64 were considered frail. Conclusions: Frailty and malnutrition in patients with CKD were independently related to all other factors examined in this study. Screening for malnutrition at the early stages in patients with CKD and the appropriate treatment may prevent the development of frailty.
{"title":"Association of frailty with nutritional parameters in patients with chronic kidney disease","authors":"Recep Evcen, M. Koçak, Rengin Elsürer Afşar","doi":"10.18621/eurj.1376545","DOIUrl":"https://doi.org/10.18621/eurj.1376545","url":null,"abstract":"Objectives: Frailty is a significant clinical syndrome characterized by greater susceptibility to stressors due to the dysfunction of multiple organ systems, which increases in prevalence with age. This study was performed to investigate relations between frailty and nutritional parameters in patients with chronic kidney disease (CKD).\u0000Methods: This cross-sectional study involved 100 CKD patients aged 50 years or older. Frailty was assessed using the Edmonton Frailty Scale (EFS) and Fried’s Frailty Scale (FFS). The patients nutritional status was assessed using the Mini Nutritional Assessment (MNA) and the routine laboratory tests.\u0000Results: The study included 100 patients, consisting of 41 females and 59 males. The mean age of the participants was 65.3±9.3 years. The median glomerular filtration rate (GFR) of the patients was 23 mL/min/1.73 m2) (min: 3-max: 65). According to the MNA, 15 patients had normal nutritional status, 63 were at risk of malnutrition, and 22 were malnourished. According to the EFS score, four patients were categorized as not frail, 11 as vulnerable, 25 with mild frailty, 21 with moderate frailty, and 39 with severe frailty. According to the FFS score, six patients were non-frail, 30 were classified as pre-frail, and 64 were considered frail. \u0000Conclusions: Frailty and malnutrition in patients with CKD were independently related to all other factors examined in this study. Screening for malnutrition at the early stages in patients with CKD and the appropriate treatment may prevent the development of frailty.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"169 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140235868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: Diagnosing fibromyalgia, a condition characterized by widespread body pain of unknown origin accompanied by various additional symptoms, poses a challenge in hemodialysis patients, who frequently experience musculoskeletal disorders. To investigate the relationship between fibromyalgia syndrome and inflammation parameters in hemodialysis patients. Methods: The study enrolled 311 hemodialysis patients undergoing treatment for over three months. Demographic characteristics, complete blood count, and biochemical values were documented as part of the study. To assess fibromyalgia, the researchers recorded the patients scores on the Generalized Pain Scale and Symptom Severity Scale based on data provided by the American College of Rheumatology. The patients were then divided into two groups: those with fibromyalgia and those without fibromyalgia, and their laboratory values and rates were compared. Inflammatory parameters such as erythrocyte sedimentation rate, c reactive protein, monocyte-to-lymphocyte ratio, lymphocyte-to-c reactive protein ratio, and c reactive protein to albumin ratio were recorded. Results: The study included 311 patients on hemodialysis for more than three months. Among the study participants, 48.9% of the patients and 62.9% of those with fibromyalgia were women. The mean age was 54±26 years and was significantly higher in patients with fibromyalgia (P<0.001). Monocyte (P<0.03), C-reactive protein (P<0.01), erythrocyte sedimentation rate (P<0.02), Monocyte to lymphocyte ratio (P=0.028), c reactive protein to albumin ratio (P<0.005) were significantly higher, lymphocyte to c reactive protein ratio (P<0.004) and albumin (P=0.018) were significantly lower in the fibromyalgia group. Conclusions: Fibromyalgia should be considered in the presence of high inflammation parameters in hemodialysis patients with diffuse musculoskeletal pain.
目的：纤维肌痛是一种以原因不明的全身广泛性疼痛并伴有各种其他症状为特征的疾病，对于经常出现肌肉骨骼疾病的血液透析患者来说，诊断纤维肌痛是一项挑战。目的：研究血液透析患者纤维肌痛综合征与炎症指标之间的关系：方法：该研究招募了 311 名接受三个多月治疗的血液透析患者。作为研究的一部分，记录了人口统计学特征、全血细胞计数和生化值。为了评估纤维肌痛，研究人员根据美国风湿病学会提供的数据，记录了患者在 "广泛疼痛量表 "和 "症状严重程度量表 "上的得分。然后，研究人员将患者分为两组：纤维肌痛患者和非纤维肌痛患者，并对他们的化验值和化验率进行了比较。记录了红细胞沉降率、c 反应蛋白、单核细胞与淋巴细胞比率、淋巴细胞与 c 反应蛋白比率以及 c 反应蛋白与白蛋白比率等炎症参数。研究结果研究对象包括 311 名血液透析超过三个月的患者。其中，48.9%的患者为女性，62.9%的纤维肌痛患者为女性。平均年龄为（54±26）岁，纤维肌痛患者的平均年龄明显更高（P<0.001）。纤维肌痛组的单核细胞（P<0.03）、C反应蛋白（P<0.01）、红细胞沉降率（P<0.02）、单核细胞与淋巴细胞比值（P=0.028）、C反应蛋白与白蛋白比值（P<0.005）明显较高，淋巴细胞与C反应蛋白比值（P<0.004）和白蛋白（P=0.018）明显较低：结论：如果血液透析患者伴有弥漫性肌肉骨骼疼痛，且炎症指标较高，则应考虑纤维肌痛。
{"title":"The relationship between fibromyalgia syndrome and inflammation parameters in hemodialysis patients","authors":"Semahat Karahisar Şirali, R. Büberci̇","doi":"10.18621/eurj.1361155","DOIUrl":"https://doi.org/10.18621/eurj.1361155","url":null,"abstract":"Objectives: Diagnosing fibromyalgia, a condition characterized by widespread body pain of unknown origin accompanied by various additional symptoms, poses a challenge in hemodialysis patients, who frequently experience musculoskeletal disorders. To investigate the relationship between fibromyalgia syndrome and inflammation parameters in hemodialysis patients.\u0000Methods: The study enrolled 311 hemodialysis patients undergoing treatment for over three months. Demographic characteristics, complete blood count, and biochemical values were documented as part of the study. To assess fibromyalgia, the researchers recorded the patients scores on the Generalized Pain Scale and Symptom Severity Scale based on data provided by the American College of Rheumatology. The patients were then divided into two groups: those with fibromyalgia and those without fibromyalgia, and their laboratory values and rates were compared. Inflammatory parameters such as erythrocyte sedimentation rate, c reactive protein, monocyte-to-lymphocyte ratio, lymphocyte-to-c reactive protein ratio, and c reactive protein to albumin ratio were recorded. \u0000Results: The study included 311 patients on hemodialysis for more than three months. Among the study participants, 48.9% of the patients and 62.9% of those with fibromyalgia were women. The mean age was 54±26 years and was significantly higher in patients with fibromyalgia (P<0.001). Monocyte (P<0.03), C-reactive protein (P<0.01), erythrocyte sedimentation rate (P<0.02), Monocyte to lymphocyte ratio (P=0.028), c reactive protein to albumin ratio (P<0.005) were significantly higher, lymphocyte to c reactive protein ratio (P<0.004) and albumin (P=0.018) were significantly lower in the fibromyalgia group.\u0000Conclusions: Fibromyalgia should be considered in the presence of high inflammation parameters in hemodialysis patients with diffuse musculoskeletal pain.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"62 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140237086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Abanoz, Mehmet Yazar, S. Talay, Candan Mansuroglu
Hydatid cyst is described as an endemic situation predominantly observed in different undeveloped regions of the world which is caused by Echinococcus granulosus tapeworm. This disease usually affects the lungs or liver. Cardiac location is reported in less than 2 % to 0.5% of patients in all cases and as in our case the intraventricular location is seen seldomly. A 38-year-old female patient with diagnosed systemic hydatid cyst disease was consulted with chest pain, palpitation, and shortness of breath. Transthoracic echocardiography and cardiac computerized tomography imaging showed the location of the cardiac hydatid cyst was the right ventricle. She underwent elective surgery swiftly and was discharged uneventfully.
{"title":"Surgical excision of the right ventricular hydatid cyst: a case report","authors":"M. Abanoz, Mehmet Yazar, S. Talay, Candan Mansuroglu","doi":"10.18621/eurj.1399415","DOIUrl":"https://doi.org/10.18621/eurj.1399415","url":null,"abstract":"Hydatid cyst is described as an endemic situation predominantly observed in different undeveloped regions of the world which is caused by Echinococcus granulosus tapeworm. This disease usually affects the lungs or liver. Cardiac location is reported in less than 2 % to 0.5% of patients in all cases and as in our case the intraventricular location is seen seldomly. A 38-year-old female patient with diagnosed systemic hydatid cyst disease was consulted with chest pain, palpitation, and shortness of breath. Transthoracic echocardiography and cardiac computerized tomography imaging showed the location of the cardiac hydatid cyst was the right ventricle. She underwent elective surgery swiftly and was discharged uneventfully.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"36 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139683706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Çağrı Coşkun, K. Kösemehmetoğlu, Mehmet Ayvaz, Ibrahim Vargel, Ü. Aydıngöz, H. Özcan, A. Varan, B. Yalçın
Myofibromas are rare benign tumors of myofibroblasts, seen more commonly in children. These tumors typically involve soft tissues with a predilection for the head and neck. Malignant neoplasia is often suspected for these rapidly growing tumors in early childhood. Clinical and radiological findings are not typical, and histopathological examination makes the definitive diagnosis. This pathology requires the intervention of a multidisciplinary team and regular follow-up. We report our experience with two children with myofibromas, one in the right arm of a 5-year-old girl and the other in the right axilla of a 9-year-old boy. Tumors were totally resected in both children, who are under follow-up with no adjuvant treatment free of disease after surgery. Myofibroma should be considered in the differential diagnosis of pediatric soft tissue tumors. Surgical resection is sufficient for treatment and patients should be followed regularly for possible recurrences.
{"title":"Solitary myofibroma in children: a report of two cases","authors":"Çağrı Coşkun, K. Kösemehmetoğlu, Mehmet Ayvaz, Ibrahim Vargel, Ü. Aydıngöz, H. Özcan, A. Varan, B. Yalçın","doi":"10.18621/eurj.1382704","DOIUrl":"https://doi.org/10.18621/eurj.1382704","url":null,"abstract":"Myofibromas are rare benign tumors of myofibroblasts, seen more commonly in children. These tumors typically involve soft tissues with a predilection for the head and neck. Malignant neoplasia is often suspected for these rapidly growing tumors in early childhood. Clinical and radiological findings are not typical, and histopathological examination makes the definitive diagnosis. This pathology requires the intervention of a multidisciplinary team and regular follow-up. We report our experience with two children with myofibromas, one in the right arm of a 5-year-old girl and the other in the right axilla of a 9-year-old boy. Tumors were totally resected in both children, who are under follow-up with no adjuvant treatment free of disease after surgery. Myofibroma should be considered in the differential diagnosis of pediatric soft tissue tumors. Surgical resection is sufficient for treatment and patients should be followed regularly for possible recurrences.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139128839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The incidence of perforations resulting from Endoscopic Retrograde Cholangiography (ERCP) is observed to be less than 1%. In this case report, we aim to present our unique experience as a mechanism, which is even more uncommon. A 68-year-old male with an ASA score of 2 was prediagnosed with a distal common bile duct tumor. ERCP was performed for therapeutic and diagnostic purposes and a 9F 10 cm plastic stent was placed to relieve obstruction. The patient, who had the sudden onset of abdominal pain within the initial 24-hour period following the procedure, underwent surgical intervention subsequent to a computed tomography assessment. In the third portion of the duodenum, an approximately 4 mm perforation originating from the stent was observed during the examination. It was repaired with a 3.0 prolene suture, followed by omentopexy. He was discharged uneventfully on the eighth day. Although duodenal perforation due to the placement of a plastic biliary stent with ERCP is a very uncommon complication, the patient's clinical and imaging findings are essential for treatment planning.
{"title":"Secondary iatrogenic duedonum perforation: a rare complication","authors":"Alperen Özdoğan, O. Ay, İsmail Yilmaz","doi":"10.18621/eurj.1356093","DOIUrl":"https://doi.org/10.18621/eurj.1356093","url":null,"abstract":"The incidence of perforations resulting from Endoscopic Retrograde Cholangiography (ERCP) is observed to be less than 1%. In this case report, we aim to present our unique experience as a mechanism, which is even more uncommon. A 68-year-old male with an ASA score of 2 was prediagnosed with a distal common bile duct tumor. ERCP was performed for therapeutic and diagnostic purposes and a 9F 10 cm plastic stent was placed to relieve obstruction. The patient, who had the sudden onset of abdominal pain within the initial 24-hour period following the procedure, underwent surgical intervention subsequent to a computed tomography assessment. In the third portion of the duodenum, an approximately 4 mm perforation originating from the stent was observed during the examination. It was repaired with a 3.0 prolene suture, followed by omentopexy. He was discharged uneventfully on the eighth day. Although duodenal perforation due to the placement of a plastic biliary stent with ERCP is a very uncommon complication, the patient's clinical and imaging findings are essential for treatment planning.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"48 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139132518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: The purpose of this research is to compare the pre and post-radiotherapy mammograms of patients who had breast-conserving surgery (BCS) and radiotherapy to see how radiotherapy affects breast arterial calcifications (BAC). Methods: The study retrospectively compared the mammography examinations at least 24 months after radiotherapy and pre-radiotherapy mammography examinations of 123 female patients diagnosed with breast cancer and treated with BCS and radiotherapy between December 2001 and July 2011. Results: Breast arterial calcifications (BAC) increased statistically significantly in 25 patients who underwent radiotherapy after BCS. Conclusion: Our results indicate that BAC increases significantly after RT, especially in breasts treated with radiotherapy, with age being also a risk factor for BAC development.
研究目的本研究的目的是比较保乳手术（BCS）和放疗患者放疗前后的乳房 X 线照片，以了解放疗对乳房动脉钙化（BAC）的影响。研究方法该研究回顾性比较了2001年12月至2011年7月期间确诊为乳腺癌并接受保乳手术和放疗的123名女性患者放疗后至少24个月的乳房X光检查和放疗前的乳房X光检查。 结果25例在BCS治疗后接受放疗的患者的乳腺动脉钙化（BAC）在统计学上明显增加。结论：我们的研究结果表明，乳房动脉钙化在 RT 后明显增加，尤其是在接受放疗的乳房中，年龄也是导致乳房动脉钙化的一个危险因素。
{"title":"Relationship of breast arterial calcification and radiotherapy","authors":"Gökhan Karataş, Osman Kula, N. Tunçbilek","doi":"10.18621/eurj.1382545","DOIUrl":"https://doi.org/10.18621/eurj.1382545","url":null,"abstract":"Objective: The purpose of this research is to compare the pre and post-radiotherapy mammograms of patients who had breast-conserving surgery (BCS) and radiotherapy to see how radiotherapy affects breast arterial calcifications (BAC). Methods: The study retrospectively compared the mammography examinations at least 24 months after radiotherapy and pre-radiotherapy mammography examinations of 123 female patients diagnosed with breast cancer and treated with BCS and radiotherapy between December 2001 and July 2011. Results: Breast arterial calcifications (BAC) increased statistically significantly in 25 patients who underwent radiotherapy after BCS. Conclusion: Our results indicate that BAC increases significantly after RT, especially in breasts treated with radiotherapy, with age being also a risk factor for BAC development.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"118 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139146273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Meltem Yilmaz, L. Mutlu, Şeref Alpsoy, Aydın Akyüz, A. Çelikkol, Özlem Kaymaz
Objectives: Chronic obstructive pulmonary disease (COPD) is a medical condition defined by persistent airflow limitation and respiratory symptoms caused by airway and/or alveolar abnormalities. Pulmonary hypertension (PH) is one of the cardiovascular comorbidities associated with COPD. We investigated the correlation of NLRC3 levels in patients with COPD with prognostic and surrogate parameters of PH on echocardiography and examined whether it could be used to predict PH in this patient population. Methods: A total of 80 patients diagnosed with COPD and 40 healthy volunteers as the control group were included in the study. The COPD group was further divided into two subgroups according to the systolic pulmonary artery pressure (sPAP) as follows: sPAP<35 mmHg and sPAP≥35 mmHg. The enzyme-linked immunosorbent assay (ELISA) method was used to determine the levels of NLRC3 in peripheral blood. Results: Patients with sPAP≥35 mmHg had a lower mean NLRC3 level than those with sPAP<35 mmHg (P=0.006). The NLRC3 levels showed a significant negative correlation with sPAP, tricuspid regurgitation velocity, right atrium, and pulmonary artery diameter. For NLRC3, the cut-off value was found to be 271,486 ng/L, with a sensitivity of 74%, and specificity of 63% in distinguishing patients with sPAP≥35 mmHg from all patients with sPAP<35 mmHg. Conclusions: Our study results suggest that NLRC3 levels measured from peripheral blood are predictive of PH in patients with COPD. Although the exact function of NLRC3 in the lungs, COPD, and PH have not been completely understood, we believe these findings will serve as a model for future studies.
{"title":"Predictive value of NLRC3 levels for pulmonary hypertension in patients with chronic obstructive pulmonary disease","authors":"Meltem Yilmaz, L. Mutlu, Şeref Alpsoy, Aydın Akyüz, A. Çelikkol, Özlem Kaymaz","doi":"10.18621/eurj.1357708","DOIUrl":"https://doi.org/10.18621/eurj.1357708","url":null,"abstract":"Objectives: Chronic obstructive pulmonary disease (COPD) is a medical condition defined by persistent airflow limitation and respiratory symptoms caused by airway and/or alveolar abnormalities. Pulmonary hypertension (PH) is one of the cardiovascular comorbidities associated with COPD. We investigated the correlation of NLRC3 levels in patients with COPD with prognostic and surrogate parameters of PH on echocardiography and examined whether it could be used to predict PH in this patient population. Methods: A total of 80 patients diagnosed with COPD and 40 healthy volunteers as the control group were included in the study. The COPD group was further divided into two subgroups according to the systolic pulmonary artery pressure (sPAP) as follows: sPAP<35 mmHg and sPAP≥35 mmHg. The enzyme-linked immunosorbent assay (ELISA) method was used to determine the levels of NLRC3 in peripheral blood. Results: Patients with sPAP≥35 mmHg had a lower mean NLRC3 level than those with sPAP<35 mmHg (P=0.006). The NLRC3 levels showed a significant negative correlation with sPAP, tricuspid regurgitation velocity, right atrium, and pulmonary artery diameter. For NLRC3, the cut-off value was found to be 271,486 ng/L, with a sensitivity of 74%, and specificity of 63% in distinguishing patients with sPAP≥35 mmHg from all patients with sPAP<35 mmHg. Conclusions: Our study results suggest that NLRC3 levels measured from peripheral blood are predictive of PH in patients with COPD. Although the exact function of NLRC3 in the lungs, COPD, and PH have not been completely understood, we believe these findings will serve as a model for future studies.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"239 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139152802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Omar, Metin Çağdaş, I. Artac, M. Karakayalı, Dogan Ilis, Ayça Arslan, Y. Karabağ, M. Yesin, Mustafa Avci, I. Rencüzoğulları
Objective: We investigated the relationship between anemia and cardiac functions by conventional and speckle-tracking echocardiography (STE) in patients with end-stage renal disease (ESRD) receiving hemodialysis. Methods: One hundred six patients with ESRD receiving hemodialysis were included in this cross-sectional study. The conventional echocardiography and STE findings were compared between the patients with and without anemia. In addition, a comparison of the findings between the ESRD patients and healthy controls consisting of 68 participants was conducted. Results: Compared to healthy controls, ESRD patients had lower left ventricular ejection fraction (LVEF), left ventricular global longitudinal strain (LVGLS), and left atrial reservoir strain (LASr) [53% (48-57) vs. 65% (62-68), -15.2 (-16.9˗ -13.6) vs. -19.7 (-16.9˗ -13.6), and -21.9 (-29.5˗ -15.3) vs. -29.9 (-35.3˗ -22.8), respectively, P-value <0.001 for all]. Of the ESRD patients, 70 (66%) had anemia. ESRD patients with anemia had higher interventricular septum (IVS), posterior wall (PW), and left atrial volume index (LAVi) values than patients without anemia. In addition, ESRD patients with anemia had lower LVEF, LVGLS, and LASr than patients without anemia [median (IQR), 13 (12-15) vs. 12 (11-14), P=0.004, 13 (12-15) vs. 12 (11-13.5), P<0.005, 43 (35-55) vs. 34.7 (28-50), P=0.013, 52 (48-55) vs. 56 (47.5-60), P=0.016, -14.6 (-16.4˗ -13.5) vs. -16 (-18.6˗ -14.7), P=0.003, and -21.6 (-30.5˗ -16.3) vs. -30.5 (-33.6˗ -23.3), P=0.006, respectively]. In multivariable logistic regression analysis, diabetes, PW, LASr, and LVGLS were independently associated with the presence of anemia in ESRD patients. Conclusion: Our study confirmed impaired cardiac mechanics in ESRD hemodialysis patients and showed that anemia was associated with further worsening cardiac mechanics in this population.
研究目的我们通过常规和斑点追踪超声心动图（STE）研究了接受血液透析的终末期肾病（ESRD）患者贫血与心脏功能之间的关系。方法这项横断面研究纳入了 16 名接受血液透析的终末期肾病患者。比较了有贫血和无贫血患者的常规超声心动图和 STE 结果。此外，还比较了 ESRD 患者和由 68 名参与者组成的健康对照组的检查结果。结果与健康对照组相比，ESRD 患者的左心室射血分数（LVEF）、左心室整体纵向应变（LVGLS）和左心房储层应变（LASr）较低[53% (48-57) vs. 65% (62-68), LASr vs. LVGLS]。分别为 53% (48-57) vs. 65% (62-68)、-15.2 (-16.9˗ -13.6) vs. -19.7 (-16.9˗ -13.6)和-21.9 (-29.5˗ -15.3) vs. -29.9 (-35.3˗ -22.8)，P 值均<0.001]。在 ESRD 患者中，70 人（66%）患有贫血。贫血的 ESRD 患者的室间隔（IVS）、后壁（PW）和左心房容积指数（LAVi）值均高于无贫血的患者。此外，贫血的 ESRD 患者的 LVEF、LVGLS 和 LASr 均低于无贫血患者[中位数（IQR），13（12-15） vs. 12（11-14），P=0.004，13（12-15） vs. 12（11-13.5），P<0.005，43（35-55） vs. 34.7（28-50），P<0.005]。分别为-14.6（-16.4˗ -13.5） vs. -16（-18.6˗ -14.7），P=0.003；以及-21.6（-30.5˗ -16.3） vs. -30.5（-33.6˗ -23.3），P=0.006]。在多变量逻辑回归分析中，糖尿病、PW、LASr 和 LVGLS 与 ESRD 患者出现贫血有独立相关性。 结论我们的研究证实了 ESRD 血液透析患者的心脏力学受损，并表明贫血与该人群心脏力学的进一步恶化有关。
{"title":"The relationship between heart functions and anemia in patients with end-stage renal disease receiving hemodialysis","authors":"T. Omar, Metin Çağdaş, I. Artac, M. Karakayalı, Dogan Ilis, Ayça Arslan, Y. Karabağ, M. Yesin, Mustafa Avci, I. Rencüzoğulları","doi":"10.18621/eurj.1401607","DOIUrl":"https://doi.org/10.18621/eurj.1401607","url":null,"abstract":"Objective: We investigated the relationship between anemia and cardiac functions by conventional and speckle-tracking echocardiography (STE) in patients with end-stage renal disease (ESRD) receiving hemodialysis. Methods: One hundred six patients with ESRD receiving hemodialysis were included in this cross-sectional study. The conventional echocardiography and STE findings were compared between the patients with and without anemia. In addition, a comparison of the findings between the ESRD patients and healthy controls consisting of 68 participants was conducted. Results: Compared to healthy controls, ESRD patients had lower left ventricular ejection fraction (LVEF), left ventricular global longitudinal strain (LVGLS), and left atrial reservoir strain (LASr) [53% (48-57) vs. 65% (62-68), -15.2 (-16.9˗ -13.6) vs. -19.7 (-16.9˗ -13.6), and -21.9 (-29.5˗ -15.3) vs. -29.9 (-35.3˗ -22.8), respectively, P-value <0.001 for all]. Of the ESRD patients, 70 (66%) had anemia. ESRD patients with anemia had higher interventricular septum (IVS), posterior wall (PW), and left atrial volume index (LAVi) values than patients without anemia. In addition, ESRD patients with anemia had lower LVEF, LVGLS, and LASr than patients without anemia [median (IQR), 13 (12-15) vs. 12 (11-14), P=0.004, 13 (12-15) vs. 12 (11-13.5), P<0.005, 43 (35-55) vs. 34.7 (28-50), P=0.013, 52 (48-55) vs. 56 (47.5-60), P=0.016, -14.6 (-16.4˗ -13.5) vs. -16 (-18.6˗ -14.7), P=0.003, and -21.6 (-30.5˗ -16.3) vs. -30.5 (-33.6˗ -23.3), P=0.006, respectively]. In multivariable logistic regression analysis, diabetes, PW, LASr, and LVGLS were independently associated with the presence of anemia in ESRD patients. Conclusion: Our study confirmed impaired cardiac mechanics in ESRD hemodialysis patients and showed that anemia was associated with further worsening cardiac mechanics in this population.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"20 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139155318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Songul Cetik Yildiz, C. Keskin, V. Şahintürk, Adnan Ayhanci
Objectives: Hypericum triquetrifolium Turra (HTT) has been traditionally used in medical treatments due to its sedative, antiseptic, antiinflammatory, and anthelmintic properties. The present study aims to investigate the lung-protective and antiapoptotic effects of HTT against cyclophosphamide (CP)-induced lung injury in rats. Methods: Thirty-five Sprague Dawley rats were categorized into 5 groups, each consisting of seven members. Phenolic acid and flavonoid contents of this plant were determined. The lung tissue samples cultivated from the rats were examined in histopathological and immunohistochemically for the apoptosis markers of Caspase-3, Bax, and Bcl-2. Results: Histopathological results indicated that structural defects, bleeding areas, and edema had occurred in the lungs of the CP-Alone Group. Besides, Caspase-3 and Bax positivity of the lung cells had also increased while Bcl-2 positivity had decreased. On the other hand, in the HTT+CP Group, HTT was shown to have reversed the aforementioned changes positively. Conclusion: Based on in vivo results, HTT could be a strong protective candidate for CP-induced lung injury and apoptosis
{"title":"The protective and antiapoptotic effects of Hypericum triquetrifolium Turra against cyclophosphamide-induced lung injury in rats: in vitro evaluation","authors":"Songul Cetik Yildiz, C. Keskin, V. Şahintürk, Adnan Ayhanci","doi":"10.18621/eurj.1373134","DOIUrl":"https://doi.org/10.18621/eurj.1373134","url":null,"abstract":"Objectives: Hypericum triquetrifolium Turra (HTT) has been traditionally used in medical treatments due to its sedative, antiseptic, antiinflammatory, and anthelmintic properties. The present study aims to investigate the lung-protective and antiapoptotic effects of HTT against cyclophosphamide (CP)-induced lung injury in rats. Methods: Thirty-five Sprague Dawley rats were categorized into 5 groups, each consisting of seven members. Phenolic acid and flavonoid contents of this plant were determined. The lung tissue samples cultivated from the rats were examined in histopathological and immunohistochemically for the apoptosis markers of Caspase-3, Bax, and Bcl-2. Results: Histopathological results indicated that structural defects, bleeding areas, and edema had occurred in the lungs of the CP-Alone Group. Besides, Caspase-3 and Bax positivity of the lung cells had also increased while Bcl-2 positivity had decreased. On the other hand, in the HTT+CP Group, HTT was shown to have reversed the aforementioned changes positively. Conclusion: Based on in vivo results, HTT could be a strong protective candidate for CP-induced lung injury and apoptosis","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"48 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139164272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gokhan Demirci, A. R. Demir, Serkan Kahraman, S. Çamcı, Emre Yilmaz
Objectives: Aortic stenosis is the most common form of degenerative heart valve disease. Acute kidney injury (AKI) after aortic valve replacement (AVR) is a common complication and is related to worse outcomes. Age, creatinine, and ejection fraction (ACEF) score is a simple scoring method that includes three parameters. Our study aimed to evaluate whether ACEF score could predict the development of AKI in patients who underwent AVR. Methods: A total of 366 consecutive patients who underwent isolated AVR for symptomatic severe aortic stenosis were evaluated retrospectively. The development of AKI was the primary endpoint of the study. The ACEF score was calculated by the formula: age (years)/left ventricular ejection fraction (%) + 1 (if baseline serum creatinine was >2 mg/dL). According to the ACEF score the study population was divided into two groups. Results: AKI was developed in 66 (18%) patients. The cut-off value of the ACEF score for the prediction of AKI was 1.07 with a sensitivity of 69.7% and a specificity of 56.7% (AUC 0.663; 95% CI: 0.589-0.736; P<0.001). AKI incidence was found to be higher in patients with high ACEF score than low ACEF score [46 (26.1%) vs. 20 (10.5%); P<0.001]. In addition, ACEF score [OR: 2.599; 95% CI: 1.399-4.828; P=0.002] and hemoglobin levels (OR: 0.837; 95% CI: 0.729-0.961; P=0.012) were found to be independent predictors of AKI. Conclusions: Our study revealed that the ACEF score is an independent predictor of AKI. ACEF score, as a simple and objective score, can be useful in predicting AKI in patients undergoing AVR.
目的：主动脉瓣狭窄是最常见的退行性心脏瓣膜病。主动脉瓣置换术（AVR）后的急性肾损伤（AKI）是一种常见的并发症，与较差的预后有关。年龄、肌酐和射血分数（ACEF）评分是一种简单的评分方法，包括三个参数。我们的研究旨在评估 ACEF 评分能否预测接受 AVR 患者发生 AKI 的情况：回顾性评估了因症状性重度主动脉瓣狭窄而接受孤立房室成形术的 366 例连续患者。发生 AKI 是研究的主要终点。ACEF 评分的计算公式为：年龄（岁）/左室射血分数（%）+1（如果基线血清肌酐大于 2 毫克/分升）。根据 ACEF 评分将研究对象分为两组：结果：66 例（18%）患者出现了 AKI。ACEF 评分预测 AKI 的临界值为 1.07，灵敏度为 69.7%，特异度为 56.7%（AUC 0.663；95% CI：0.589-0.736；P<0.001）。发现 ACEF 得分高的患者 AKI 发生率高于 ACEF 得分低的患者 [46 (26.1%) vs. 20 (10.5%); P<0.001]。此外，ACEF评分[OR：2.599；95% CI：1.399-4.828；P=0.002]和血红蛋白水平（OR：0.837；95% CI：0.729-0.961；P=0.012）是AKI的独立预测因素。结论我们的研究显示，ACEF 评分是 AKI 的独立预测因子。ACEF 评分作为一种简单而客观的评分，可用于预测接受 AVR 患者的 AKI。
{"title":"Predictive value of ACEF score for acute kidney injury after surgical aortic valve replacement","authors":"Gokhan Demirci, A. R. Demir, Serkan Kahraman, S. Çamcı, Emre Yilmaz","doi":"10.18621/eurj.1334048","DOIUrl":"https://doi.org/10.18621/eurj.1334048","url":null,"abstract":"Objectives: Aortic stenosis is the most common form of degenerative heart valve disease. Acute kidney injury (AKI) after aortic valve replacement (AVR) is a common complication and is related to worse outcomes. Age, creatinine, and ejection fraction (ACEF) score is a simple scoring method that includes three parameters. Our study aimed to evaluate whether ACEF score could predict the development of AKI in patients who underwent AVR.\u0000Methods: A total of 366 consecutive patients who underwent isolated AVR for symptomatic severe aortic stenosis were evaluated retrospectively. The development of AKI was the primary endpoint of the study. The ACEF score was calculated by the formula: age (years)/left ventricular ejection fraction (%) + 1 (if baseline serum creatinine was >2 mg/dL). According to the ACEF score the study population was divided into two groups.\u0000Results: AKI was developed in 66 (18%) patients. The cut-off value of the ACEF score for the prediction of AKI was 1.07 with a sensitivity of 69.7% and a specificity of 56.7% (AUC 0.663; 95% CI: 0.589-0.736; P<0.001). AKI incidence was found to be higher in patients with high ACEF score than low ACEF score [46 (26.1%) vs. 20 (10.5%); P<0.001]. In addition, ACEF score [OR: 2.599; 95% CI: 1.399-4.828; P=0.002] and hemoglobin levels (OR: 0.837; 95% CI: 0.729-0.961; P=0.012) were found to be independent predictors of AKI. \u0000Conclusions: Our study revealed that the ACEF score is an independent predictor of AKI. ACEF score, as a simple and objective score, can be useful in predicting AKI in patients undergoing AVR.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"27 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138952295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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