Objectives: Ticks are vectors of a number of pathogens, which cause diseases with fatal consequences, therefore it is essential to detect such pathogens from single tick. Molecular methods like polymerase chain reaction (PCR) are offering such possibilities. At present, cumbersome methods involving liquid nitrogen, cutting ticks with scalpels as well as pooled ticks are being used worldwide. Our goal is to develop a reliable and fast method to obtain nucleic acid (DNA/RNA) from the single tick shipped at room temperature to detect various pathogens. Methods: We developed a mechanical crushing method with mini column nucleic acid isolation from a single tick shipped at room temperature with postal or currier service in a letter. PCR detection was done for Borrelia burgdorferi and tick-borne encephalitis virus as examples. Results: This method was used successfully for the isolation of nucleic acid from single tick and later used for PCR detection of B. burgdorferi and tick-borne encephalitis virus on 17 single tick samples as examples, but for last 18 years, this method was used on more than 250 ticks from Germany. Spectrometric values indicate the presence of sufficient yield of DNA and RNA (up to 900 µg/mL per tick) during the isolation. Conclusions: This may be the first report about a number of one single tick cases, which were sent at room temperature in letters with postal services for isolation of the nucleic acid with mini column kit and used later on for PCR detection of various pathogens. This inexpensive and simple method may be used in any laboratory worldwide for monitoring the presence of tick-borne pathogens.
{"title":"A simple, effective and inexpensive method to isolate the nucleic acid (DNA/RNA) from a single tick for molecular detection of various pathogens","authors":"Sudhir BHATİA, Gudrun BAERSCH","doi":"10.18621/eurj.1315058","DOIUrl":"https://doi.org/10.18621/eurj.1315058","url":null,"abstract":"Objectives: Ticks are vectors of a number of pathogens, which cause diseases with fatal consequences, therefore it is essential to detect such pathogens from single tick. Molecular methods like polymerase chain reaction (PCR) are offering such possibilities. At present, cumbersome methods involving liquid nitrogen, cutting ticks with scalpels as well as pooled ticks are being used worldwide. Our goal is to develop a reliable and fast method to obtain nucleic acid (DNA/RNA) from the single tick shipped at room temperature to detect various pathogens. Methods: We developed a mechanical crushing method with mini column nucleic acid isolation from a single tick shipped at room temperature with postal or currier service in a letter. PCR detection was done for Borrelia burgdorferi and tick-borne encephalitis virus as examples. Results: This method was used successfully for the isolation of nucleic acid from single tick and later used for PCR detection of B. burgdorferi and tick-borne encephalitis virus on 17 single tick samples as examples, but for last 18 years, this method was used on more than 250 ticks from Germany. Spectrometric values indicate the presence of sufficient yield of DNA and RNA (up to 900 µg/mL per tick) during the isolation. Conclusions: This may be the first report about a number of one single tick cases, which were sent at room temperature in letters with postal services for isolation of the nucleic acid with mini column kit and used later on for PCR detection of various pathogens. This inexpensive and simple method may be used in any laboratory worldwide for monitoring the presence of tick-borne pathogens.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135939024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: The main objective of this study is to assess the relationship between the level of Health Literacy and the patient's decision to refuse the Gestational diabetes mellitus screening test. Methods: This cross-sectional study was conducted at a high-volume public hospital from March 2020 to September 2020 with women between 24-28 weeks of gestation. Demographic characteristics and gestational diabetes mellitus screening status were recorded for each woman. The European Health Literacy Survey Questionnaire was used to assess health literacy. Results: A total of 364 women were included in the study. Two hundred and three (55.7%) women accepted the gestational diabetes mellitus screening test, and 44.2% did not. Health care, disease prevention, health promotion subscales, and the general scale scores were higher in the gestational diabetes mellitus screening group (p = 0.001, p = 0.024, p = 0.01, and p = 0.003, respectively). It was determined that a 1-point increase in the health care score decreased the probability of rejecting the gestational diabetes mellitus screening by 1.03 times (p = 0.003). Conclusions: Lower health literacy levels were associated with higher rates of gestational diabetes mellitus screening test rejection.
目的:本研究的主要目的是评估健康素养水平与患者拒绝妊娠糖尿病筛查试验的关系。方法:本横断面研究于2020年3月至2020年9月在一家大容量公立医院进行，研究对象为妊娠24-28周的妇女。记录每位妇女的人口统计学特征和妊娠期糖尿病筛查情况。欧洲健康素养调查问卷用于评估健康素养。结果:共有364名女性被纳入研究。203名(55.7%)妇女接受了妊娠期糖尿病筛查试验，44.2%未接受。妊娠期糖尿病筛查组的保健、疾病预防、健康促进亚量表和一般量表得分较高(p = 0.001, p = 0.024, p = 0.01, p = 0.003)。结果表明，健康护理评分每增加1分，拒绝妊娠糖尿病筛查的概率降低1.03倍(p = 0.003)。结论:较低的健康素养水平与较高的妊娠期糖尿病筛查试验拒绝率相关。
{"title":"Does health literacy affect the decision to have gestational diabetes screening test?","authors":"Özlem Özgün UYANIKLAR, Zeliha ATAK, Sakine RAHIMLI OCAKOGLU, Hatice ORTAÇ, Gökhan OCAKOĞLU","doi":"10.18621/eurj.1291335","DOIUrl":"https://doi.org/10.18621/eurj.1291335","url":null,"abstract":"Objectives: The main objective of this study is to assess the relationship between the level of Health Literacy and the patient's decision to refuse the Gestational diabetes mellitus screening test. Methods: This cross-sectional study was conducted at a high-volume public hospital from March 2020 to September 2020 with women between 24-28 weeks of gestation. Demographic characteristics and gestational diabetes mellitus screening status were recorded for each woman. The European Health Literacy Survey Questionnaire was used to assess health literacy. Results: A total of 364 women were included in the study. Two hundred and three (55.7%) women accepted the gestational diabetes mellitus screening test, and 44.2% did not. Health care, disease prevention, health promotion subscales, and the general scale scores were higher in the gestational diabetes mellitus screening group (p = 0.001, p = 0.024, p = 0.01, and p = 0.003, respectively). It was determined that a 1-point increase in the health care score decreased the probability of rejecting the gestational diabetes mellitus screening by 1.03 times (p = 0.003). Conclusions: Lower health literacy levels were associated with higher rates of gestational diabetes mellitus screening test rejection.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135939214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: Ulcerative colitis (UC) is an inflammatory disease restricted to the colon's mucosal layer. UC is a complex disease with a largely unknown etiology. Mendelian Randomization (MR) is a method that uses variations in genes that have a causal effect of a modifiable exposure to the disease, in genetic epidemiological studies. Trefoil factor 3 (TFF3) is a secreted protein expressed mainly in the colonic mucosa that binds with the mucin 2 protein, forming a protective barrier for the colon mucosa from bacteria and other insults. This study aimed to identify if TFF3 levels in plasma are causally associated with UC. Methods: We performed a two-sample MR study. For exposure instrumental variables (IVs), genetically determined TFF3 levels in plasma proteome quantitative trait locus data were obtained from the published literature. Outcome data were obtained from the GWAS catalog. The “TwoSampleMR” R package was used for MR. The statistical significance of IV effect sizes on the outcome is mainly evaluated by the inverse variance weighted (IVW) method. Results: The IVW test showed considerable statistical significance in all analyzed outcomes except for Crohn’s disease (CD) samples. Heterogeneity and horizontal pleiotropy tests showed no significant results for MR sensitivity analysis. Conclusions: We showed that TFF3 levels in plasma were causally associated with the risk of UC. Increased levels of TFF3 are reversely associated with the risk of UC. The absence of any causal relationship between TFF3 and CD from the same study cohort also supports our causal inference.
{"title":"Genetically determined plasma trefoil factor-3 levels are causally associated with the risk of ulcerative colitis: a Mendelian randomization study","authors":"B. Toraman, Sami Fi̇dan, Gökhan Yildiz","doi":"10.18621/eurj.1285889","DOIUrl":"https://doi.org/10.18621/eurj.1285889","url":null,"abstract":"Objectives: Ulcerative colitis (UC) is an inflammatory disease restricted to the colon's mucosal layer. UC is a complex disease with a largely unknown etiology. Mendelian Randomization (MR) is a method that uses variations in genes that have a causal effect of a modifiable exposure to the disease, in genetic epidemiological studies. Trefoil factor 3 (TFF3) is a secreted protein expressed mainly in the colonic mucosa that binds with the mucin 2 protein, forming a protective barrier for the colon mucosa from bacteria and other insults. This study aimed to identify if TFF3 levels in plasma are causally associated with UC.\u0000Methods: We performed a two-sample MR study. For exposure instrumental variables (IVs), genetically determined TFF3 levels in plasma proteome quantitative trait locus data were obtained from the published literature. Outcome data were obtained from the GWAS catalog. The “TwoSampleMR” R package was used for MR. The statistical significance of IV effect sizes on the outcome is mainly evaluated by the inverse variance weighted (IVW) method.\u0000Results: The IVW test showed considerable statistical significance in all analyzed outcomes except for Crohn’s disease (CD) samples. Heterogeneity and horizontal pleiotropy tests showed no significant results for MR sensitivity analysis. \u0000Conclusions: We showed that TFF3 levels in plasma were causally associated with the risk of UC. Increased levels of TFF3 are reversely associated with the risk of UC. The absence of any causal relationship between TFF3 and CD from the same study cohort also supports our causal inference.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84672681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: Fibromyalgia syndrome (FMS) is a stress-related disease. The birth of a child with cerebral palsy (CP) is an important stress factor for the mother. This study aims to investigate the incidence of FMS in mothers of children with CP by comparing it with the control group and determining the factors affecting the severity of FMS. Methods: The study included 112 children with CP (age: 38-216 months), their caregiver mother (age: 23-50 years) (Group 1) and 52 non-disabled children (age: 40-180 months), their caregiver mothers (age: 27-50 years) (Group 2). Children were evaluated with the Gross Motor Function Classification System (GMFCS) and the functional independence scale for children (WeeFIM). The mothers were evaluated according to the 2010 ACR FMS diagnostic criteria. The FMS Impact Questionnaire (FIQ), the Hospital Anxiety and Depression Scale (HADS), and the Bakas Caregiving Outcomes Scale (BCOS) were applied. Results: In Group 1, mothers had higher anxiety-depression scores and caregiving burden than Group 2 (p < 0.05). FMS rate was %31.3 in Group 1 and %5.7 in Group 2. Mothers' anxiety-depression scores, widespread pain index, symptom severity score, pain, and caregiver burden were higher in Group 1 than in Group 2 (p < 0.05). Factors affecting the severity of FMS are the number of siblings of children with CP, the number of siblings with CP, GMFCS, dependence level, anxiety-depression levels of mothers, and caregiver burden. The most influential factor is the caregiver burden. Conclusions: Long-term heavy caregiver burden in mothers of children with CP may be effective in developing FMS.
{"title":"Fibromyalgia syndrome in mothers of children with cerebral palsy and its relationship with caregiver burden: a cross-sectional study","authors":"İlknur AYKURT KARLIBEL, Meliha KASAPOĞLU AKSOY, Merve YENİ","doi":"10.18621/eurj.1292729","DOIUrl":"https://doi.org/10.18621/eurj.1292729","url":null,"abstract":"Objectives: Fibromyalgia syndrome (FMS) is a stress-related disease. The birth of a child with cerebral palsy (CP) is an important stress factor for the mother. This study aims to investigate the incidence of FMS in mothers of children with CP by comparing it with the control group and determining the factors affecting the severity of FMS. Methods: The study included 112 children with CP (age: 38-216 months), their caregiver mother (age: 23-50 years) (Group 1) and 52 non-disabled children (age: 40-180 months), their caregiver mothers (age: 27-50 years) (Group 2). Children were evaluated with the Gross Motor Function Classification System (GMFCS) and the functional independence scale for children (WeeFIM). The mothers were evaluated according to the 2010 ACR FMS diagnostic criteria. The FMS Impact Questionnaire (FIQ), the Hospital Anxiety and Depression Scale (HADS), and the Bakas Caregiving Outcomes Scale (BCOS) were applied. Results: In Group 1, mothers had higher anxiety-depression scores and caregiving burden than Group 2 (p &lt; 0.05). FMS rate was %31.3 in Group 1 and %5.7 in Group 2. Mothers' anxiety-depression scores, widespread pain index, symptom severity score, pain, and caregiver burden were higher in Group 1 than in Group 2 (p &lt; 0.05). Factors affecting the severity of FMS are the number of siblings of children with CP, the number of siblings with CP, GMFCS, dependence level, anxiety-depression levels of mothers, and caregiver burden. The most influential factor is the caregiver burden. Conclusions: Long-term heavy caregiver burden in mothers of children with CP may be effective in developing FMS.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136108449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Çağrı Coşkun, Necla Buyan, C. Türkyilmaz, Y. Atalay, Sevcan Azime BAKKALOĞLU EZGÜ
Objectives: The objective of this study is to identify factors that affect the severity of acute kidney injury (AKI) using neonatal RIFLE (Risk, Injury, Failure, Loss of function, End-stage kidney disease) criteria; to identify the impact of these criteria and the factors on mortality rates and to determine the one-year clinical outcome. Methods: Five hundred and thirty-two inpatients who were admitted to Gazi University, Faculty of Medicine, Neonatal Intensive Care Unit (NICU) between 2006 and 2016 have been examined retrospectively. Results: Acute kidney injury developed in the first month of life in 85 (16%) patients. Thirty-nine (7.35%) of the cases were term and 46 (8.65%) were preterm. Among these patients, 33 (38.8%) were in the risk group, 18 (21%) in the injury group, and 34 (40%) in the failure group. Metabolic acidosis and edema were the most commonly seen findings as acute kidney injury scores increased. According to the neonatal RIFLE (nRIFLE) criteria, the severity of AKI was significantly correlated (p < 0.05) with metabolic acidosis (71%) and edema (50.5%). There was a positive correlation between urinary output and pH, bicarbonate, glomerular filtration rate, and sodium values in patients with AKI, while a negative correlation between urinary output and BUN, creatinine, potassium, phosphorus, and uric acid was found. Regarding the nRIFLE criteria, the frequency of hyponatremia and hyperpotassemia was increased as the AKI severity score was increasing (p < 0.05). The mortality rate was 54% in the newborn period and factors that significantly affect mortality were the need for mechanical ventilation, sepsis, nephrotoxicity, and acidosis (p < 0.05). Conclusions: The nRIFLE criteria based on urinary output is a guide for clinicians to diagnose AKI. There is a need to work on new markers in future studies.
{"title":"Acute kidney injury in neonatal intensive care unit and the significance of nRIFLE criteria on diagnosis and prognosis","authors":"Çağrı Coşkun, Necla Buyan, C. Türkyilmaz, Y. Atalay, Sevcan Azime BAKKALOĞLU EZGÜ","doi":"10.18621/eurj.1319806","DOIUrl":"https://doi.org/10.18621/eurj.1319806","url":null,"abstract":"Objectives: The objective of this study is to identify factors that affect the severity of acute kidney injury (AKI) using neonatal RIFLE (Risk, Injury, Failure, Loss of function, End-stage kidney disease) criteria; to identify the impact of these criteria and the factors on mortality rates and to determine the one-year clinical outcome.\u0000Methods: Five hundred and thirty-two inpatients who were admitted to Gazi University, Faculty of Medicine, Neonatal Intensive Care Unit (NICU) between 2006 and 2016 have been examined retrospectively. \u0000Results: Acute kidney injury developed in the first month of life in 85 (16%) patients. Thirty-nine (7.35%) of the cases were term and 46 (8.65%) were preterm. Among these patients, 33 (38.8%) were in the risk group, 18 (21%) in the injury group, and 34 (40%) in the failure group. Metabolic acidosis and edema were the most commonly seen findings as acute kidney injury scores increased. According to the neonatal RIFLE (nRIFLE) criteria, the severity of AKI was significantly correlated (p < 0.05) with metabolic acidosis (71%) and edema (50.5%). There was a positive correlation between urinary output and pH, bicarbonate, glomerular filtration rate, and sodium values in patients with AKI, while a negative correlation between urinary output and BUN, creatinine, potassium, phosphorus, and uric acid was found. Regarding the nRIFLE criteria, the frequency of hyponatremia and hyperpotassemia was increased as the AKI severity score was increasing (p < 0.05). The mortality rate was 54% in the newborn period and factors that significantly affect mortality were the need for mechanical ventilation, sepsis, nephrotoxicity, and acidosis (p < 0.05).\u0000Conclusions: The nRIFLE criteria based on urinary output is a guide for clinicians to diagnose AKI. There is a need to work on new markers in future studies.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76691816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: Chronic venous insufficiency (CVI) is one of the most common venous diseases. CVI is an important clinical picture with a high prevalence, low quality of life, and high diagnosis and treatment costs. Therefore, diagnosis, follow-up, and treatment are important for the patient's socioeconomic and life quality. In this study, we aimed to better examine a test used in the diagnosis, treatment, and follow-up of CVI. Methods: In this retrospective study, 683 patients diagnosed with CVI, who had endovenous laser ablation (EVLA) indications were evaluated between June 2013 and November 2018. EVLA procedure performed on all patients. Preoperative, postoperative 1st and 6th month Doppler USG (ultrasonography), plethysmography, and VCSS (Venous Clinical Severity Score) questionnaire was made to all patients. Results: As a result of our study, we found that there was a significant difference between the preoperative plethysmography and VCSS results of the patients and the postoperative 1st and 6th month results. With the significant difference in the VCSS questionnaire, we have shown that plethysmography gives accurate results in the diagnosis and treatment of CVI since it is an individual, quantitative, and easy test. Conclusions: EVLA is an effective and safe method in patients with venous insufficiency. Since Doppler USG is person and device dependent, we think that plethysmography, which can be used in every clinical setting and provides quantitative results independent of the person, can be used more frequently in the diagnosis and treatment of venous insufficiency. In addition, we think that plethysmography can be used as a valuable additional method in the diagnosis and follow-up of such patients, due to the venous hemodynamic data that Doppler USG cannot provide.
{"title":"Can plethysmography have a greater place in the diagnosis, treatment and follow-up of chronic venous insufficiency?","authors":"Temmuz Taner, Hakan Guven","doi":"10.18621/eurj.1294890","DOIUrl":"https://doi.org/10.18621/eurj.1294890","url":null,"abstract":"Objectives: Chronic venous insufficiency (CVI) is one of the most common venous diseases. CVI is an important clinical picture with a high prevalence, low quality of life, and high diagnosis and treatment costs. Therefore, diagnosis, follow-up, and treatment are important for the patient's socioeconomic and life quality. In this study, we aimed to better examine a test used in the diagnosis, treatment, and follow-up of CVI.\u0000Methods: In this retrospective study, 683 patients diagnosed with CVI, who had endovenous laser ablation (EVLA) indications were evaluated between June 2013 and November 2018. EVLA procedure performed on all patients. Preoperative, postoperative 1st and 6th month Doppler USG (ultrasonography), plethysmography, and VCSS (Venous Clinical Severity Score) questionnaire was made to all patients. \u0000Results: As a result of our study, we found that there was a significant difference between the preoperative plethysmography and VCSS results of the patients and the postoperative 1st and 6th month results. With the significant difference in the VCSS questionnaire, we have shown that plethysmography gives accurate results in the diagnosis and treatment of CVI since it is an individual, quantitative, and easy test.\u0000Conclusions: EVLA is an effective and safe method in patients with venous insufficiency. Since Doppler USG is person and device dependent, we think that plethysmography, which can be used in every clinical setting and provides quantitative results independent of the person, can be used more frequently in the diagnosis and treatment of venous insufficiency. In addition, we think that plethysmography can be used as a valuable additional method in the diagnosis and follow-up of such patients, due to the venous hemodynamic data that Doppler USG cannot provide.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85112406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The use of mobile health applications is vital for achieving glycemic control, promoting lifestyle changes, and empowering self-management in individuals with type 2 diabetes. This literature review aims to assess the effectiveness of mobile health applications in empowering self-management among type 2 diabetes patients. A thorough search was conducted in databases like PubMed, CINAHL, Web of Science, Cochrane Library, Scopus, ULAKBIM National Database, and Medline between January 2020 and March 2023, using keywords such as "mobile health, mobile applications, type 2 diabetes, diabetes self-management, nursing." The search yielded 525 articles, out of which 34 studies in Turkish or English that evaluated the effectiveness of mobile health applications in individuals aged 18 years and above with type 2 diabetes were included in the review. Recent studies demonstrate a growing utilization of mobile health applications for the management of treatment and care in individuals with type 2 diabetes. These applications have been shown to empower self-management by promoting dietary adherence, regular blood sugar monitoring, regular physical activity, reduced medication requirements, and decreased HbA1c levels. Additionally, mobile health applications have been found to reduce face-to-face counseling time and healthcare costs. In conclusion, mobile health applications offer promising solutions for improving self-management and healthcare outcomes for individuals with type 2 diabetes. Further research and continued integration of these applications into clinical practice are essential to optimize their benefits and address the challenges faced by diabetes patients worldwide.
移动健康应用程序的使用对于2型糖尿病患者实现血糖控制、促进生活方式改变和增强自我管理能力至关重要。本文献综述旨在评估移动健康应用程序在增强2型糖尿病患者自我管理方面的有效性。在2020年1月至2023年3月期间，在PubMed、CINAHL、Web of Science、Cochrane Library、Scopus、ULAKBIM National Database和Medline等数据库中进行了彻底的搜索，使用的关键词是“移动健康、移动应用、2型糖尿病、糖尿病自我管理、护理”。检索结果为525篇文章，其中34篇土耳其语或英语研究评估了移动健康应用程序对18岁及以上2型糖尿病患者的有效性。最近的研究表明，移动医疗应用程序越来越多地用于管理2型糖尿病患者的治疗和护理。这些应用程序通过促进饮食坚持、定期血糖监测、定期体育活动、减少药物需求和降低糖化血红蛋白水平，增强了自我管理的能力。此外，人们发现移动医疗应用程序可以减少面对面咨询的时间和医疗成本。总之，移动医疗应用程序为改善2型糖尿病患者的自我管理和医疗保健结果提供了有希望的解决方案。进一步的研究和将这些应用持续整合到临床实践中对于优化其益处和解决全球糖尿病患者面临的挑战至关重要。
{"title":"The use of mobile health applications in empowering self-management of type 2 diabetes: a literature review","authors":"Pelin Öcal","doi":"10.18621/eurj.1320822","DOIUrl":"https://doi.org/10.18621/eurj.1320822","url":null,"abstract":"The use of mobile health applications is vital for achieving glycemic control, promoting lifestyle changes, and empowering self-management in individuals with type 2 diabetes. This literature review aims to assess the effectiveness of mobile health applications in empowering self-management among type 2 diabetes patients. A thorough search was conducted in databases like PubMed, CINAHL, Web of Science, Cochrane Library, Scopus, ULAKBIM National Database, and Medline between January 2020 and March 2023, using keywords such as \"mobile health, mobile applications, type 2 diabetes, diabetes self-management, nursing.\" The search yielded 525 articles, out of which 34 studies in Turkish or English that evaluated the effectiveness of mobile health applications in individuals aged 18 years and above with type 2 diabetes were included in the review. Recent studies demonstrate a growing utilization of mobile health applications for the management of treatment and care in individuals with type 2 diabetes. These applications have been shown to empower self-management by promoting dietary adherence, regular blood sugar monitoring, regular physical activity, reduced medication requirements, and decreased HbA1c levels. Additionally, mobile health applications have been found to reduce face-to-face counseling time and healthcare costs. In conclusion, mobile health applications offer promising solutions for improving self-management and healthcare outcomes for individuals with type 2 diabetes. Further research and continued integration of these applications into clinical practice are essential to optimize their benefits and address the challenges faced by diabetes patients worldwide.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76153205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: The aim of this retrospective study was to evaluate the effects of bringing low-density lipoprotein cholesterol (LDL-C) values to levels in line with guideline recommendations on long-term mortality in patients with a known history of coronary artery disease (CAD), undergoing transcatheter aortic valve implantation (TAVI), and long-term pre-treatment with statins. Methods: This is a retrospective and observational study of patients undergoing TAVI at a tertiary heart center with a history of CAD and long-term statin therapy. Ninety-nine patients were included in the study. The relationship between LDL-C levels in accordance with the guidelines and 5-year mortality was determined by regression analysis. Results: When the study population was divided into 2 groups with and without 5-year mortality, LDL-C values were found to be significantly higher in the mortality group (120 mg/dL vs. 93.9 mg/dL, p < 0.001). Parameters associated with the development of 5-year mortality were evaluated with univariate and multivariate logistic regression analysis. LDL-C ≥ 100 mg/dL (OR: 6.59, 95% CI: 2.17-20.01) and LDL-C ≥ 70 mg/dL (OR:3.88, 95% CI: 1.16-12.93) parameters were determined as independent predictors of mortality independent of other parameters. Conclusions: The most important result obtained in this study is that achieving the LDL-C level targets specified in the guidelines significantly reduces the in-hospital and 5-year mortality rates in patients with a previous history of CAD and statin use and undergoing TAVI. Although all patients included in the study used statins, the mortality rate was significantly higher in patients who did not reach the target LDL-C value.
目的:本回顾性研究的目的是评估将低密度脂蛋白胆固醇(LDL-C)值降至符合指南建议的水平对已知冠状动脉疾病(CAD)病史、接受经导管主动脉瓣置入术(TAVI)和长期他汀类药物预处理的患者的长期死亡率的影响。方法:这是一项回顾性和观察性研究，在三级心脏中心接受TAVI的患者有CAD病史和长期他汀类药物治疗。99名患者参与了这项研究。通过回归分析确定指南中LDL-C水平与5年死亡率之间的关系。结果:将研究人群分为有5年死亡率和无5年死亡率两组时，发现死亡率组LDL-C值显著高于死亡率组(120 mg/dL vs. 93.9 mg/dL, p < 0.001)。采用单因素和多因素logistic回归分析评估与5年死亡率发展相关的参数。LDL-C≥100 mg/dL (OR: 6.59, 95% CI: 2.17-20.01)和LDL-C≥70 mg/dL (OR:3.88, 95% CI: 1.16-12.93)参数被确定为独立于其他参数的死亡率预测因子。结论:本研究获得的最重要的结果是，达到指南规定的LDL-C水平目标可显著降低有CAD和他汀类药物使用史并接受TAVI的患者的住院死亡率和5年死亡率。尽管纳入研究的所有患者均使用他汀类药物，但未达到LDL-C目标值的患者死亡率明显较高。
{"title":"The effect of achieving guideline-based target low-density lipoprotein cholesterol levels on mortality in transcatheter aortic valve implantation patients with coronary artery disease","authors":"Ö. Demir, F. Levent","doi":"10.18621/eurj.1341976","DOIUrl":"https://doi.org/10.18621/eurj.1341976","url":null,"abstract":"Objectives: The aim of this retrospective study was to evaluate the effects of bringing low-density lipoprotein cholesterol (LDL-C) values to levels in line with guideline recommendations on long-term mortality in patients with a known history of coronary artery disease (CAD), undergoing transcatheter aortic valve implantation (TAVI), and long-term pre-treatment with statins. \u0000Methods: This is a retrospective and observational study of patients undergoing TAVI at a tertiary heart center with a history of CAD and long-term statin therapy. Ninety-nine patients were included in the study. The relationship between LDL-C levels in accordance with the guidelines and 5-year mortality was determined by regression analysis. \u0000Results: When the study population was divided into 2 groups with and without 5-year mortality, LDL-C values were found to be significantly higher in the mortality group (120 mg/dL vs. 93.9 mg/dL, p < 0.001). Parameters associated with the development of 5-year mortality were evaluated with univariate and multivariate logistic regression analysis. LDL-C ≥ 100 mg/dL (OR: 6.59, 95% CI: 2.17-20.01) and LDL-C ≥ 70 mg/dL (OR:3.88, 95% CI: 1.16-12.93) parameters were determined as independent predictors of mortality independent of other parameters. \u0000Conclusions: The most important result obtained in this study is that achieving the LDL-C level targets specified in the guidelines significantly reduces the in-hospital and 5-year mortality rates in patients with a previous history of CAD and statin use and undergoing TAVI. Although all patients included in the study used statins, the mortality rate was significantly higher in patients who did not reach the target LDL-C value.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74922331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kahraman GÜLER, Zeynep GÜMÜŞ DEMİR, Cansu Selin YURTSEVEN
Objectives: This paper looked into the relation between childhood traumas, resilience, cognitive flexibility, and adult emotion regulation skills in adults. Methods: The sample, which is based on the relational screening model, includes 395 participants (female: 202, male: 193). Sociodemographic Information Form, Childhood Trauma Questionnaire, Connor-Davidson Resilience Scale, Cognitive Flexibility Scale and Cognitive Emotion Regulation Questionnaire were applied to the participants to obtain the research data. Data collection was carried out online (google forms) through convenient sampling. The t-test was used to compare the study's quantitative data, and Pearson Correlation analysis was utilized to test the relationship between the scales. Multiple Linear Regression analysis was used for predictive analysis and finally PROCESS was used for mediator role analysis. Results: The investigation's findings revealed that there is a statistically significant difference between the scores of the two groups compared. Findings showed that there is a moderately positive correlation between acceptance and CTQ scores, a weak positive correlation between acceptance and emotional abuse scores, a weak positive correlation with physical abuse scores, a weak positive correlation with physical neglect scores, a weak positive correlation with emotional neglect scores and weak positive correlation with sexual abuse scores. A weak and negative correlation exists between Putting into Perspective and the CTQ, an even weaker and negative correlation exists between Putting into Perspective and the Emotional Neglect and Sexual Abuse scores. Rumination scores have a weak and negative relationship with emotional abuse scores. Conclusions: In order to prevent them from serving as the foundation for difficulties with adult mental health, it is crucial to understand the relationship between traumatic childhood events and psychological resilience, cognitive flexibility, and cognitive emotion regulation techniques. In order to assist people, analyze their thoughts and feelings, be aware of negative coping mechanisms, rigid, inflexible cognitive styles, and negative thinking patterns, clinical psychology practices will benefit from research on these characteristics.
{"title":"Investigation of the relationship between childhood traumas, psychological resilience, cognitive flexibility and emotion regulation skills in adults","authors":"Kahraman GÜLER, Zeynep GÜMÜŞ DEMİR, Cansu Selin YURTSEVEN","doi":"10.18621/eurj.1279884","DOIUrl":"https://doi.org/10.18621/eurj.1279884","url":null,"abstract":"Objectives: This paper looked into the relation between childhood traumas, resilience, cognitive flexibility, and adult emotion regulation skills in adults. Methods: The sample, which is based on the relational screening model, includes 395 participants (female: 202, male: 193). Sociodemographic Information Form, Childhood Trauma Questionnaire, Connor-Davidson Resilience Scale, Cognitive Flexibility Scale and Cognitive Emotion Regulation Questionnaire were applied to the participants to obtain the research data. Data collection was carried out online (google forms) through convenient sampling. The t-test was used to compare the study's quantitative data, and Pearson Correlation analysis was utilized to test the relationship between the scales. Multiple Linear Regression analysis was used for predictive analysis and finally PROCESS was used for mediator role analysis. Results: The investigation's findings revealed that there is a statistically significant difference between the scores of the two groups compared. Findings showed that there is a moderately positive correlation between acceptance and CTQ scores, a weak positive correlation between acceptance and emotional abuse scores, a weak positive correlation with physical abuse scores, a weak positive correlation with physical neglect scores, a weak positive correlation with emotional neglect scores and weak positive correlation with sexual abuse scores. A weak and negative correlation exists between Putting into Perspective and the CTQ, an even weaker and negative correlation exists between Putting into Perspective and the Emotional Neglect and Sexual Abuse scores. Rumination scores have a weak and negative relationship with emotional abuse scores. Conclusions: In order to prevent them from serving as the foundation for difficulties with adult mental health, it is crucial to understand the relationship between traumatic childhood events and psychological resilience, cognitive flexibility, and cognitive emotion regulation techniques. In order to assist people, analyze their thoughts and feelings, be aware of negative coping mechanisms, rigid, inflexible cognitive styles, and negative thinking patterns, clinical psychology practices will benefit from research on these characteristics.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135499341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nazım Erkurt, Mustafa Yerli, A. Yüce, T. Bayraktar, S. Atar, Kaya Turan, H. Çabuk
Objectives: This study evaluates the effect of tibial stump mechanoreceptor preservation on proprioception, muscle strength, recovery and functional outcomes after arthroscopic anterior cruciate ligament surgery (ACLS). Methods: Patients undergoing ACLS between January-July 2019 were evaluated by a single surgeon. The HUMAC NORM 2 device measured patients' proprioceptive sensation and muscle strength before and after surgery; KOOS and Oxford scales were used to score patients’ functional results. The patients were divided into two groups: those who underwent stump-preserving surgery (SP group) and those who underwent conventional surgery (C group). Results: Our study evaluated 27 patients, 11 in the SP and 16 in the C groups. The two groups had no statistical difference in muscle strength, proprioception, and functional scores in the first and third postoperative months. In the sixth-month evaluation, significantly better functional scores were found in the C group. Further, the athletic function was better in patients with good proprioception recovery, regardless of the group comparison. Conclusions: Preserving the stump and mechanoreceptors on the tibial face was not determined to provide additional benefit to the patients in the first six months after surgery. Returning to sports was faster and functional scores were better in patients with good proprioception recovery.
{"title":"Proprioception analysis of patients with anterior cruciate ligament reconstruction","authors":"Nazım Erkurt, Mustafa Yerli, A. Yüce, T. Bayraktar, S. Atar, Kaya Turan, H. Çabuk","doi":"10.18621/eurj.1265826","DOIUrl":"https://doi.org/10.18621/eurj.1265826","url":null,"abstract":"Objectives: This study evaluates the effect of tibial stump mechanoreceptor preservation on proprioception, muscle strength, recovery and functional outcomes after arthroscopic anterior cruciate ligament surgery (ACLS).\u0000Methods: Patients undergoing ACLS between January-July 2019 were evaluated by a single surgeon. The HUMAC NORM 2 device measured patients' proprioceptive sensation and muscle strength before and after surgery; KOOS and Oxford scales were used to score patients’ functional results. The patients were divided into two groups: those who underwent stump-preserving surgery (SP group) and those who underwent conventional surgery (C group).\u0000Results: Our study evaluated 27 patients, 11 in the SP and 16 in the C groups. The two groups had no statistical difference in muscle strength, proprioception, and functional scores in the first and third postoperative months. In the sixth-month evaluation, significantly better functional scores were found in the C group. Further, the athletic function was better in patients with good proprioception recovery, regardless of the group comparison.\u0000Conclusions: Preserving the stump and mechanoreceptors on the tibial face was not determined to provide additional benefit to the patients in the first six months after surgery. Returning to sports was faster and functional scores were better in patients with good proprioception recovery.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72886453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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