IL-17 promotes collagen deposition by cancer-associated fibroblasts and enhances immune exclusion of tumors.
IL-17促进癌症相关成纤维细胞的胶原沉积，增强肿瘤的免疫排斥。
{"title":"Matrix reboot: IL-17 signals CAFs to create a second tumor T cell checkpoint","authors":"M. McGeachy","doi":"10.1084/jem.20220444","DOIUrl":"https://doi.org/10.1084/jem.20220444","url":null,"abstract":"IL-17 promotes collagen deposition by cancer-associated fibroblasts and enhances immune exclusion of tumors.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73731252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Hasebe, K. Murakami, Masaya Harada, N. Halaka, H. Nakagawa, F. Kawano, Y. Ohira, T. Kawamoto, F. Yull, T. Blackwell, J. Nio-Kobayashi, Toshihiko Iwanaga, Masahiko Watanabe, N. Watanabe, H. Hotta, T. Yamashita, D. Kamimura, Yuki Tanaka, M. Murakami
Local inflammation spreads to remote positions via sensory neuron–interneuron crosstalk using ATP. This neural pathway, or remote inflammation gateway reflex, may be a therapeutic target for inflammatory diseases with remote inflammation, such as rheumatoid arthritis.
{"title":"ATP spreads inflammation to other limbs through crosstalk between sensory neurons and interneurons","authors":"R. Hasebe, K. Murakami, Masaya Harada, N. Halaka, H. Nakagawa, F. Kawano, Y. Ohira, T. Kawamoto, F. Yull, T. Blackwell, J. Nio-Kobayashi, Toshihiko Iwanaga, Masahiko Watanabe, N. Watanabe, H. Hotta, T. Yamashita, D. Kamimura, Yuki Tanaka, M. Murakami","doi":"10.1084/jem.20212019","DOIUrl":"https://doi.org/10.1084/jem.20212019","url":null,"abstract":"Local inflammation spreads to remote positions via sensory neuron–interneuron crosstalk using ATP. This neural pathway, or remote inflammation gateway reflex, may be a therapeutic target for inflammatory diseases with remote inflammation, such as rheumatoid arthritis.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86780798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yikun Yao, Ping Du Jiang, B. Chao, D. Çağdaş, S. Kubo, Arasu Balasubramaniyam, Yu Zhang, B. Shadur, A. NaserEddin, L. Folio, Benjamin Schwarz, Eric Bohrnsen, Lixin Zheng, Matthew Lynberg, Simone Gottlieb, Michael A. Leney-Greene, Ann Y. Park, I. Tezcan, A. Akdoğan, R. Gocmen, S. Onder, A. Rosenberg, E. Soilleux, Errin Johnson, P. Jackson, J. Demeter, Samuel D. Chauvin, F. Paul, M. Selbach, H. Bulut, M. Clatworthy, Z. Tuong, Hanlin Zhang, B. Stewart, C. Bosio, P. Stepensky, S. Clare, S. Ganesan, J. Pascall, O. Daumke, G. Butcher, A. McMichael, A. Simon, M. Lenardo
Yao et al. describe GIMAP6 deficiency in humans and mice showing immune dysfunction and susceptibility to bacterial infections. They find impaired autophagy in GIMAP6-deficient immune cells and define a functional complex composed of GIMAP6, GIMAP7, and GABARAPL2.
{"title":"GIMAP6 regulates autophagy, immune competence, and inflammation in mice and humans","authors":"Yikun Yao, Ping Du Jiang, B. Chao, D. Çağdaş, S. Kubo, Arasu Balasubramaniyam, Yu Zhang, B. Shadur, A. NaserEddin, L. Folio, Benjamin Schwarz, Eric Bohrnsen, Lixin Zheng, Matthew Lynberg, Simone Gottlieb, Michael A. Leney-Greene, Ann Y. Park, I. Tezcan, A. Akdoğan, R. Gocmen, S. Onder, A. Rosenberg, E. Soilleux, Errin Johnson, P. Jackson, J. Demeter, Samuel D. Chauvin, F. Paul, M. Selbach, H. Bulut, M. Clatworthy, Z. Tuong, Hanlin Zhang, B. Stewart, C. Bosio, P. Stepensky, S. Clare, S. Ganesan, J. Pascall, O. Daumke, G. Butcher, A. McMichael, A. Simon, M. Lenardo","doi":"10.1084/jem.20201405","DOIUrl":"https://doi.org/10.1084/jem.20201405","url":null,"abstract":"Yao et al. describe GIMAP6 deficiency in humans and mice showing immune dysfunction and susceptibility to bacterial infections. They find impaired autophagy in GIMAP6-deficient immune cells and define a functional complex composed of GIMAP6, GIMAP7, and GABARAPL2.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"116 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89330039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
As the first immune cells to colonize tissues and long-lived resident cells, macrophages play important roles in tissue functions during early development, homeostasis, and disease. Here, Chakarov et al. discuss macrophage origin and functions in adipose tissue and how these features are modulated in obesity.
{"title":"Role of adipose tissue macrophages in obesity-related disorders","authors":"S. Chakarov, Camille Blériot, F. Ginhoux","doi":"10.1084/jem.20211948","DOIUrl":"https://doi.org/10.1084/jem.20211948","url":null,"abstract":"As the first immune cells to colonize tissues and long-lived resident cells, macrophages play important roles in tissue functions during early development, homeostasis, and disease. Here, Chakarov et al. discuss macrophage origin and functions in adipose tissue and how these features are modulated in obesity.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76313113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Reporting the distribution and inclusion of both males and females in immunology and infectious diseases research is improving, but rigorous analyses of differential outcomes between males and females, including mechanistic inquiries into the causes of sex differences, still lags behind.
{"title":"Sex biases in infectious diseases research","authors":"S. Dhakal, Sabal Chaulagain, S. Klein","doi":"10.1084/jem.20211486","DOIUrl":"https://doi.org/10.1084/jem.20211486","url":null,"abstract":"Reporting the distribution and inclusion of both males and females in immunology and infectious diseases research is improving, but rigorous analyses of differential outcomes between males and females, including mechanistic inquiries into the causes of sex differences, still lags behind.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"90 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84309407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Masahiko Nishitani-Isa, Kojiro Mukai, Y. Honda, H. Nihira, Takayuki Tanaka, H. Shibata, K. Kodama, E. Hiejima, K. Izawa, Yuri Kawasaki, M. Osawa, Yu Katata, Sachiko Onodera, Tatsuya Watanabe, T. Uchida, S. Kure, J. Takita, O. Ohara, M. Saito, R. Nishikomori, T. Taguchi, Y. Sasahara, T. Yasumi
Using induced pluripotent stem cells carrying CDC42R186C, trapping of CDC42 C-terminal variants within the Golgi apparatus is shown to trigger autoinflammation by promoting pyrin inflammasome assembly through a mechanism independent of their GTPase activity.
{"title":"Trapping of CDC42 C-terminal variants in the Golgi drives pyrin inflammasome hyperactivation","authors":"Masahiko Nishitani-Isa, Kojiro Mukai, Y. Honda, H. Nihira, Takayuki Tanaka, H. Shibata, K. Kodama, E. Hiejima, K. Izawa, Yuri Kawasaki, M. Osawa, Yu Katata, Sachiko Onodera, Tatsuya Watanabe, T. Uchida, S. Kure, J. Takita, O. Ohara, M. Saito, R. Nishikomori, T. Taguchi, Y. Sasahara, T. Yasumi","doi":"10.1084/jem.20211889","DOIUrl":"https://doi.org/10.1084/jem.20211889","url":null,"abstract":"Using induced pluripotent stem cells carrying CDC42R186C, trapping of CDC42 C-terminal variants within the Golgi apparatus is shown to trigger autoinflammation by promoting pyrin inflammasome assembly through a mechanism independent of their GTPase activity.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"82 2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73056184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xixi Tao, Rui Zhang, Ronglu Du, Tingting Yu, H. Yang, Jiwen Li, Yuhong Wang, Qian Liu, Shengkai Zuo, Xi Wang, M. Lazarus, Lu Zhou, Bangmao Wang, Yingjia Yu, Yujun Shen
Tao et al. describe that activation of E-prostanoid 3 receptor (EP3) ameliorates injury-induced liver fibrosis through promoting NK cell adhesion and killing of activated hepatic stellate cells in mice, indicating that EP3 may serve as a potential therapeutic target for liver fibrosis.
{"title":"EP3 enhances adhesion and cytotoxicity of NK cells toward hepatic stellate cells in a murine liver fibrosis model","authors":"Xixi Tao, Rui Zhang, Ronglu Du, Tingting Yu, H. Yang, Jiwen Li, Yuhong Wang, Qian Liu, Shengkai Zuo, Xi Wang, M. Lazarus, Lu Zhou, Bangmao Wang, Yingjia Yu, Yujun Shen","doi":"10.1084/jem.20212414","DOIUrl":"https://doi.org/10.1084/jem.20212414","url":null,"abstract":"Tao et al. describe that activation of E-prostanoid 3 receptor (EP3) ameliorates injury-induced liver fibrosis through promoting NK cell adhesion and killing of activated hepatic stellate cells in mice, indicating that EP3 may serve as a potential therapeutic target for liver fibrosis.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73013768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Discussion on the divergent immunological effects of pregnancy on T cell and humoral immunity, how prior pregnancy impacts responses upon alloantigen re-encounter in the context of solid organ transplantation, and potential strategies for controlling pregnancy-dependent allosensitization.
{"title":"Toward an understanding of allogeneic conflict in pregnancy and transplantation","authors":"Samarth S Durgam, M. Alegre, A. Chong","doi":"10.1084/jem.20211493","DOIUrl":"https://doi.org/10.1084/jem.20211493","url":null,"abstract":"Discussion on the divergent immunological effects of pregnancy on T cell and humoral immunity, how prior pregnancy impacts responses upon alloantigen re-encounter in the context of solid organ transplantation, and potential strategies for controlling pregnancy-dependent allosensitization.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76374254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this issue of Journal of Experimental Medicine, Yin et al. (2022) discover that loss of FNIP1 is associated with browning of white adipose tissue, which they propose is driven by decreased calcium uptake into the ER.
{"title":"Calcium burns beige","authors":"Jakub Bunk, L. Kazak","doi":"10.1084/jem.20220382","DOIUrl":"https://doi.org/10.1084/jem.20220382","url":null,"abstract":"In this issue of Journal of Experimental Medicine, Yin et al. (2022) discover that loss of FNIP1 is associated with browning of white adipose tissue, which they propose is driven by decreased calcium uptake into the ER.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"153 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74720451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yujing Yin, Dengqiu Xu, Yan Mao, Liwei Xiao, Zongchao Sun, Jing Liu, Danxia Zhou, Zhisheng Xu, Lin Liu, Tingting Fu, Chenyun Ding, Qiqi Guo, Wanping Sun, Zheng Zhou, Likun Yang, Yuhuan Jia, Xinyi Chen, Z. Gan
Metabolically beneficial beige adipocytes offer tremendous potential to treat obesity and metabolic diseases. Yin et al. show that FNIP1 acts as a negative regulator of beige adipocyte thermogenesis to control systemic glucose homeostasis through modulating the ER Ca2+-ATPase SERCA.
{"title":"FNIP1 regulates adipocyte browning and systemic glucose homeostasis in mice by shaping intracellular calcium dynamics","authors":"Yujing Yin, Dengqiu Xu, Yan Mao, Liwei Xiao, Zongchao Sun, Jing Liu, Danxia Zhou, Zhisheng Xu, Lin Liu, Tingting Fu, Chenyun Ding, Qiqi Guo, Wanping Sun, Zheng Zhou, Likun Yang, Yuhuan Jia, Xinyi Chen, Z. Gan","doi":"10.1084/jem.20212491","DOIUrl":"https://doi.org/10.1084/jem.20212491","url":null,"abstract":"Metabolically beneficial beige adipocytes offer tremendous potential to treat obesity and metabolic diseases. Yin et al. show that FNIP1 acts as a negative regulator of beige adipocyte thermogenesis to control systemic glucose homeostasis through modulating the ER Ca2+-ATPase SERCA.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76288431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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