Following the discovery of plasmacytoid dendritic cells (pDCs) and of their extraordinary ability to produce type I IFNs (IFN-I) in response to TLR7 and TLR9 stimulation, it is assumed that their main function is to participate in the antiviral response. There is increasing evidence suggesting that pDCs and/or IFN-I can also have a detrimental role in a number of inflammatory and autoimmune diseases, in the context of chronic viral infections and in cancers. Whether these cells should be targeted in patients and how much of their biology is connected to IFN-I production remains unclear and is discussed here.
{"title":"A pathogenic role of plasmacytoid dendritic cells in autoimmunity and chronic viral infection.","authors":"F. Barrat, L. Su","doi":"10.1084/jem.20181359","DOIUrl":"https://doi.org/10.1084/jem.20181359","url":null,"abstract":"Following the discovery of plasmacytoid dendritic cells (pDCs) and of their extraordinary ability to produce type I IFNs (IFN-I) in response to TLR7 and TLR9 stimulation, it is assumed that their main function is to participate in the antiviral response. There is increasing evidence suggesting that pDCs and/or IFN-I can also have a detrimental role in a number of inflammatory and autoimmune diseases, in the context of chronic viral infections and in cancers. Whether these cells should be targeted in patients and how much of their biology is connected to IFN-I production remains unclear and is discussed here.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"74 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83754105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ping-Hsien Lee, Tori N. Yamamoto, Devikala Gurusamy, M. Sukumar, Zhiya Yu, J. Hu‐Li, T. Kawabe, Arunakumar Gangaplara, R. Kishton, A. Henning, S. Vodnala, R. Germain, W. Paul, N. Restifo
Lee et al. reveal that administration of IL-1β can alter the host environment to augment the magnitude and functionality of CD8+ T cells, thereby improving the efficacy of adoptively transferred tumor-reactive T cells in treating large, established tumors in mice.
{"title":"Host conditioning with IL-1β improves the antitumor function of adoptively transferred T cells","authors":"Ping-Hsien Lee, Tori N. Yamamoto, Devikala Gurusamy, M. Sukumar, Zhiya Yu, J. Hu‐Li, T. Kawabe, Arunakumar Gangaplara, R. Kishton, A. Henning, S. Vodnala, R. Germain, W. Paul, N. Restifo","doi":"10.1084/jem.20181218","DOIUrl":"https://doi.org/10.1084/jem.20181218","url":null,"abstract":"Lee et al. reveal that administration of IL-1β can alter the host environment to augment the magnitude and functionality of CD8+ T cells, thereby improving the efficacy of adoptively transferred tumor-reactive T cells in treating large, established tumors in mice.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"40 1","pages":"2619 - 2634"},"PeriodicalIF":0.0,"publicationDate":"2019-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79587697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Sullivan, P. Dalal, F. Jaulin, D. Sacks, G. Kreitzer, W. Muller
The function of endothelial cell IQGAP1 during diapedesis requires its actin-binding domain and IQ motifs to recruit the lateral border recycling compartment. Genetic ablation of endothelial cell IQGAP1 expression in vivo causes significant disruption of diapedesis in two models of inflammation.
{"title":"Endothelial IQGAP1 regulates leukocyte transmigration by directing the LBRC to the site of diapedesis","authors":"D. Sullivan, P. Dalal, F. Jaulin, D. Sacks, G. Kreitzer, W. Muller","doi":"10.1084/jem.20190008","DOIUrl":"https://doi.org/10.1084/jem.20190008","url":null,"abstract":"The function of endothelial cell IQGAP1 during diapedesis requires its actin-binding domain and IQ motifs to recruit the lateral border recycling compartment. Genetic ablation of endothelial cell IQGAP1 expression in vivo causes significant disruption of diapedesis in two models of inflammation.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"131 1","pages":"2582 - 2601"},"PeriodicalIF":0.0,"publicationDate":"2019-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79193292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Bradley, Carmen K. Denecke, Almir Aljović, Anja Schmalz, M. Kerschensteiner, F. Bareyre
This study investigates the principles of target selection during the remodeling of neuronal circuits following spinal cord injury. It demonstrates that remodeling axons select their postsynaptic partners in an activity-dependent competitive process that is critical for functional recovery after injury.
{"title":"Corticospinal circuit remodeling after central nervous system injury is dependent on neuronal activity","authors":"P. Bradley, Carmen K. Denecke, Almir Aljović, Anja Schmalz, M. Kerschensteiner, F. Bareyre","doi":"10.1084/jem.20181406","DOIUrl":"https://doi.org/10.1084/jem.20181406","url":null,"abstract":"This study investigates the principles of target selection during the remodeling of neuronal circuits following spinal cord injury. It demonstrates that remodeling axons select their postsynaptic partners in an activity-dependent competitive process that is critical for functional recovery after injury.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"1 1","pages":"2503 - 2514"},"PeriodicalIF":0.0,"publicationDate":"2019-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83005088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-06DOI: 10.1084/jem.2019049007302019c
M. Nagasawa, B. Heesters, C. Kradolfer, L. Krabbendam, Itziar Martinez-Gonzalez, Marjolein J. W. de Bruijn, K. Golebski, R. Hendriks, R. Stadhouders, H. Spits, S. Bal
2221 https://doi.org/10.1084/jem.20190490 J. Exp. Med. 2019 Vol. 216 No. 9 2221 Rockefeller University Press Correction: KLRG1 and NKp46 discriminate subpopulations of human CD117+CRTH2− ILCs biased toward ILC2 or ILC3 Maho Nagasawa, Balthasar A. Heesters, Chantal M.A. Kradolfer, Lisette Krabbendam, Itziar Martinez-Gonzalez, Marjolein J.W. de Bruijn, Korneliusz Golebski, Rudi W. Hendriks, Ralph Stadhouders, Hergen Spits, and Suzanne M. Bal
{"title":"Correction: KLRG1 and NKp46 discriminate subpopulations of human CD117+CRTH2− ILCs biased toward ILC2 or ILC3","authors":"M. Nagasawa, B. Heesters, C. Kradolfer, L. Krabbendam, Itziar Martinez-Gonzalez, Marjolein J. W. de Bruijn, K. Golebski, R. Hendriks, R. Stadhouders, H. Spits, S. Bal","doi":"10.1084/jem.2019049007302019c","DOIUrl":"https://doi.org/10.1084/jem.2019049007302019c","url":null,"abstract":"2221 https://doi.org/10.1084/jem.20190490 J. Exp. Med. 2019 Vol. 216 No. 9 2221 Rockefeller University Press Correction: KLRG1 and NKp46 discriminate subpopulations of human CD117+CRTH2− ILCs biased toward ILC2 or ILC3 Maho Nagasawa, Balthasar A. Heesters, Chantal M.A. Kradolfer, Lisette Krabbendam, Itziar Martinez-Gonzalez, Marjolein J.W. de Bruijn, Korneliusz Golebski, Rudi W. Hendriks, Ralph Stadhouders, Hergen Spits, and Suzanne M. Bal","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"1 1","pages":"2221 - 2222"},"PeriodicalIF":0.0,"publicationDate":"2019-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89735165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-05Epub Date: 2019-07-18DOI: 10.1084/jem.20191048
Yihai Cao
The mechanism of maintaining vascular endothelial identity and integrity is largely unknown. In this issue of JEM, Ricard et al. (https://doi.org/10.1084/jem.20182151) discover essential roles of ERK1/2 in maintaining endothelial homeostasis and its deletion-related serious defects in multiple tissues and organs.
{"title":"Endothelial life discontinues without Erk.","authors":"Yihai Cao","doi":"10.1084/jem.20191048","DOIUrl":"10.1084/jem.20191048","url":null,"abstract":"<p><p>The mechanism of maintaining vascular endothelial identity and integrity is largely unknown. In this issue of <i>JEM</i>, Ricard et al. (https://doi.org/10.1084/jem.20182151) discover essential roles of ERK1/2 in maintaining endothelial homeostasis and its deletion-related serious defects in multiple tissues and organs.</p>","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"216 1","pages":"1730-1732"},"PeriodicalIF":0.0,"publicationDate":"2019-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78595876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Etzerodt, Kyriaki Tsalkitzi, M. Maniecki, W. Damsky, Marcello Delfini, E. Baudoin, Morgane Moulin, M. Bosenberg, J. Graversen, N. Auphan-Anezin, S. Moestrup, T. Lawrence
Etzerodt et al. show that the specific targeting of CD163+ macrophages in melanoma drives inflammatory monocyte influx and promotes antitumor immunity, illustrating the importance of selective targeting of tumor-associated myeloid cells for achieving optimal therapeutic responses.
{"title":"Specific targeting of CD163+ TAMs mobilizes inflammatory monocytes and promotes T cell–mediated tumor regression","authors":"A. Etzerodt, Kyriaki Tsalkitzi, M. Maniecki, W. Damsky, Marcello Delfini, E. Baudoin, Morgane Moulin, M. Bosenberg, J. Graversen, N. Auphan-Anezin, S. Moestrup, T. Lawrence","doi":"10.1084/jem.20182124","DOIUrl":"https://doi.org/10.1084/jem.20182124","url":null,"abstract":"Etzerodt et al. show that the specific targeting of CD163+ macrophages in melanoma drives inflammatory monocyte influx and promotes antitumor immunity, illustrating the importance of selective targeting of tumor-associated myeloid cells for achieving optimal therapeutic responses.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"20 1","pages":"2394 - 2411"},"PeriodicalIF":0.0,"publicationDate":"2019-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85169244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Martin, Nainita Roy, Sohini Chakraborty, A. Desrichard, S. Chung, Carolien M Woolthuis, Wenhuo Hu, Iryna Berezniuk, Francine E. Garrett-Bakelman, J. Hamann, S. Devlin, T. Chan, Christopher Y. Park
Martin et al. demonstrate that CD97 is a critical regulator of leukemia stem cell (LSC) function. CD97 is overexpressed in the vast majority of AML patients and promotes AML blast growth, survival, and differentiation. Collectively, these data credential CD97 as a novel and promising therapeutic target in AML.
{"title":"CD97 is a critical regulator of acute myeloid leukemia stem cell function","authors":"G. Martin, Nainita Roy, Sohini Chakraborty, A. Desrichard, S. Chung, Carolien M Woolthuis, Wenhuo Hu, Iryna Berezniuk, Francine E. Garrett-Bakelman, J. Hamann, S. Devlin, T. Chan, Christopher Y. Park","doi":"10.1084/jem.20190598","DOIUrl":"https://doi.org/10.1084/jem.20190598","url":null,"abstract":"Martin et al. demonstrate that CD97 is a critical regulator of leukemia stem cell (LSC) function. CD97 is overexpressed in the vast majority of AML patients and promotes AML blast growth, survival, and differentiation. Collectively, these data credential CD97 as a novel and promising therapeutic target in AML.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"19 1","pages":"2362 - 2377"},"PeriodicalIF":0.0,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72723344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wenhan Zhu, N. Miyata, M. Winter, A. Arenales, Elizabeth R Hughes, Luisella Spiga, Jiwoong Kim, Luis Sifuentes-Dominguez, P. Starokadomskyy, P. Gopal, Mariana X. Byndloss, R. Santos, E. Burstein, S. Winter
Enterobacteriaceae family members such as E. coli exacerbate development of intestinal malignancy. Zhu et al. report that targeting the metabolism of protumoral Enterobacteriaceae by tungstate prevents tumor development in murine models of colitis-associated colorectal cancer.
{"title":"Editing of the gut microbiota reduces carcinogenesis in mouse models of colitis-associated colorectal cancer","authors":"Wenhan Zhu, N. Miyata, M. Winter, A. Arenales, Elizabeth R Hughes, Luisella Spiga, Jiwoong Kim, Luis Sifuentes-Dominguez, P. Starokadomskyy, P. Gopal, Mariana X. Byndloss, R. Santos, E. Burstein, S. Winter","doi":"10.1084/jem.20181939","DOIUrl":"https://doi.org/10.1084/jem.20181939","url":null,"abstract":"Enterobacteriaceae family members such as E. coli exacerbate development of intestinal malignancy. Zhu et al. report that targeting the metabolism of protumoral Enterobacteriaceae by tungstate prevents tumor development in murine models of colitis-associated colorectal cancer.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"17 1","pages":"2378 - 2393"},"PeriodicalIF":0.0,"publicationDate":"2019-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90466619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Bancroft, B. Debuysscher, C. Weidle, A. Schwartz, A. Wall, M. Gray, Junli Feng, H. Steach, K. Fitzpatrick, M. Gewe, Patrick D. Skog, C. Doyle-Cooper, T. Ota, R. Strong, D. Nemazee, M. Pancera, L. Stamatatos, A. McGuire, Justin J. Taylor
An anti-idiotype recognizing the germline version of a broadly neutralizing antibody was utilized to identify human B cells expressing similar germline antibodies and was converted to an immunogen to stimulate transgenic murine B cells in vivo despite the presence of anergy.
{"title":"Detection and activation of HIV broadly neutralizing antibody precursor B cells using anti-idiotypes","authors":"T. Bancroft, B. Debuysscher, C. Weidle, A. Schwartz, A. Wall, M. Gray, Junli Feng, H. Steach, K. Fitzpatrick, M. Gewe, Patrick D. Skog, C. Doyle-Cooper, T. Ota, R. Strong, D. Nemazee, M. Pancera, L. Stamatatos, A. McGuire, Justin J. Taylor","doi":"10.1084/jem.20190164","DOIUrl":"https://doi.org/10.1084/jem.20190164","url":null,"abstract":"An anti-idiotype recognizing the germline version of a broadly neutralizing antibody was utilized to identify human B cells expressing similar germline antibodies and was converted to an immunogen to stimulate transgenic murine B cells in vivo despite the presence of anergy.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"97 1","pages":"2331 - 2347"},"PeriodicalIF":0.0,"publicationDate":"2019-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76668928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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