In this study, Wang et al. demonstrate that lncRNA-encoded polypeptide ASRPS is down-regulated in TNBC. ASRPS regulates angiogenesis and may serve as a novel prognostic marker and therapeutic target for TNBC.
{"title":"LncRNA-encoded polypeptide ASRPS inhibits triple-negative breast cancer angiogenesis","authors":"Yirong Wang, Siqi Wu, Xun Zhu, Liyuan Zhang, Jieqiong Deng, Fang Li, Binbin Guo, Sheng-hua Zhang, Rui Wu, Zheng Zhang, Kexin Wang, Jiachun Lu, Yifeng Zhou","doi":"10.1084/jem.20190950","DOIUrl":"https://doi.org/10.1084/jem.20190950","url":null,"abstract":"In this study, Wang et al. demonstrate that lncRNA-encoded polypeptide ASRPS is down-regulated in TNBC. ASRPS regulates angiogenesis and may serve as a novel prognostic marker and therapeutic target for TNBC.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76093885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Haiyan Zhao, Lily Xu, Robin Bombardi, Rachel S. Nargi, Z. Deng, J. Errico, C. Nelson, Kimberly A. Dowd, T. Pierson, J. Crowe, M. Diamond, D. Fremont
Evaluation of the human antibody response to Zika virus has identified common germline-derived mAbs capable of cross flavivirus neutralization. Zhao et al. provide a detailed mechanistic understanding of how flavivirus infections are prevented in a strain-specific manner by a representative mAb.
{"title":"Mechanism of differential Zika and dengue virus neutralization by a public antibody lineage targeting the DIII lateral ridge","authors":"Haiyan Zhao, Lily Xu, Robin Bombardi, Rachel S. Nargi, Z. Deng, J. Errico, C. Nelson, Kimberly A. Dowd, T. Pierson, J. Crowe, M. Diamond, D. Fremont","doi":"10.1084/jem.20191792","DOIUrl":"https://doi.org/10.1084/jem.20191792","url":null,"abstract":"Evaluation of the human antibody response to Zika virus has identified common germline-derived mAbs capable of cross flavivirus neutralization. Zhao et al. provide a detailed mechanistic understanding of how flavivirus infections are prevented in a strain-specific manner by a representative mAb.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90464412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tingting Weng, Jing-Jing Huang, E. Wagner, Junsuk Ko, Minghua Wu, N. Wareing, Yu Xiang, Ning-yuan Chen, Ping Ji, Jose G. Molina, K. Volcik, Leng Han, M. Mayes, M. Blackburn, S. Assassi
This study implicates the key regulator of alternative polyadenylation, CFIm25 in dermal fibrosis and in systemic sclerosis (scleroderma) pathogenesis. CFIm25 downregulation promotes the expression of profibrotic factors, exaggerates bleomycin-induced skin fibrosis, while CFIm25 restoration attenuates skin fibrosis.
{"title":"Downregulation of CFIm25 amplifies dermal fibrosis through alternative polyadenylation","authors":"Tingting Weng, Jing-Jing Huang, E. Wagner, Junsuk Ko, Minghua Wu, N. Wareing, Yu Xiang, Ning-yuan Chen, Ping Ji, Jose G. Molina, K. Volcik, Leng Han, M. Mayes, M. Blackburn, S. Assassi","doi":"10.1084/jem.20181384","DOIUrl":"https://doi.org/10.1084/jem.20181384","url":null,"abstract":"This study implicates the key regulator of alternative polyadenylation, CFIm25 in dermal fibrosis and in systemic sclerosis (scleroderma) pathogenesis. CFIm25 downregulation promotes the expression of profibrotic factors, exaggerates bleomycin-induced skin fibrosis, while CFIm25 restoration attenuates skin fibrosis.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79412982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Single-cell transcriptome analysis of epithelial cells from human ileum, colon, and rectum reveals different nutrient-absorption preferences in the small and large intestine, providing a rich resource for further characterization of human intestine cell constitution and functions.
{"title":"Single-cell transcriptome analysis reveals differential nutrient absorption functions in human intestine","authors":"Yalong Wang, Wanlu Song, Jilian Wang, Ting Wang, X. Xiong, Zhen Qi, W. Fu, Xuerui Yang, Ye-Guang Chen","doi":"10.1084/jem.20191130","DOIUrl":"https://doi.org/10.1084/jem.20191130","url":null,"abstract":"Single-cell transcriptome analysis of epithelial cells from human ileum, colon, and rectum reveals different nutrient-absorption preferences in the small and large intestine, providing a rich resource for further characterization of human intestine cell constitution and functions.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75590863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Arroyo and Pepper demonstrate that interactions with B cells, not dendritic cells, are required for the priming of the CD4+ T cell response during Plasmodium infection. This results in a Tfh-biased response as reported by others in both mice and humans.
{"title":"B cells are sufficient to prime the dominant CD4+ Tfh response to Plasmodium infection","authors":"E. N. Arroyo, M. Pepper","doi":"10.1084/jem.20190849","DOIUrl":"https://doi.org/10.1084/jem.20190849","url":null,"abstract":"Arroyo and Pepper demonstrate that interactions with B cells, not dendritic cells, are required for the priming of the CD4+ T cell response during Plasmodium infection. This results in a Tfh-biased response as reported by others in both mice and humans.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77332465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-15DOI: 10.1084/jem.2018037111082019c
Delphine Ohayon, Alessia De Chiara, P. My-Chan Dang, N. Thieblemont, Simon M. Chatfield, V. Marzaioli, S. S. Burgener, Julie Mocek, C. Candalh, Coralie Pintard, P. Tacnet-Delorme, G. Renault, I. Lagoutte, M. Favier, Francine Walker, M. Hurtado-Nedelec, D. Desplancq, E. Weiss, C. Benarafa, D. Housset, J. Marie, P. Frachet, J. El-Benna, V. Witko-Sarsat
2900 https://doi.org/10.1084/jem.20180371 J. Exp. Med. 2019 Vol. 216 No. 12 2900 Rockefeller University Press Correction: Cytosolic PCNA interacts with p47phox and controls NADPH oxidase NOX2 activation in neutrophils Delphine Ohayon, Alessia De Chiara, Pham My-Chan Dang, Nathalie Th ieblemont, Simon Chatfi eld, Viviana Marzaioli, Sabrina Sofi a Burgener, Julie Mocek, Céline Candalh, Coralie Pintard, Pascale Tacnet-Delorme, Gilles Renault, Isabelle Lagoutte, Maryline Favier, Francine Walker, Margarita Hurtado-Nedelec, Dominique Desplancq, Etienne Weiss, Charaf Benarafa, Dominique Housset, Jean-Claude Marie, Philippe Frachet, Jamel El-Benna, and Véronique Witko-Sarsat
{"title":"Correction: Cytosolic PCNA interacts with p47phox and controls NADPH oxidase NOX2 activation in neutrophils","authors":"Delphine Ohayon, Alessia De Chiara, P. My-Chan Dang, N. Thieblemont, Simon M. Chatfield, V. Marzaioli, S. S. Burgener, Julie Mocek, C. Candalh, Coralie Pintard, P. Tacnet-Delorme, G. Renault, I. Lagoutte, M. Favier, Francine Walker, M. Hurtado-Nedelec, D. Desplancq, E. Weiss, C. Benarafa, D. Housset, J. Marie, P. Frachet, J. El-Benna, V. Witko-Sarsat","doi":"10.1084/jem.2018037111082019c","DOIUrl":"https://doi.org/10.1084/jem.2018037111082019c","url":null,"abstract":"2900 https://doi.org/10.1084/jem.20180371 J. Exp. Med. 2019 Vol. 216 No. 12 2900 Rockefeller University Press Correction: Cytosolic PCNA interacts with p47phox and controls NADPH oxidase NOX2 activation in neutrophils Delphine Ohayon, Alessia De Chiara, Pham My-Chan Dang, Nathalie Th ieblemont, Simon Chatfi eld, Viviana Marzaioli, Sabrina Sofi a Burgener, Julie Mocek, Céline Candalh, Coralie Pintard, Pascale Tacnet-Delorme, Gilles Renault, Isabelle Lagoutte, Maryline Favier, Francine Walker, Margarita Hurtado-Nedelec, Dominique Desplancq, Etienne Weiss, Charaf Benarafa, Dominique Housset, Jean-Claude Marie, Philippe Frachet, Jamel El-Benna, and Véronique Witko-Sarsat","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"23 1","pages":"2900 - 2900"},"PeriodicalIF":0.0,"publicationDate":"2019-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78211753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This review discusses the growing literature on the pathogenic role of IL-17 in cancer, focusing on recent studies that place IL-17 as a nexus linking inflammation, tissue repair, and cancer.
{"title":"The role of interleukin-17 in tumor development and progression","authors":"Junjie Zhao, Xing Chen, T. Herjan, Xiaoxia Li","doi":"10.1084/jem.20190297","DOIUrl":"https://doi.org/10.1084/jem.20190297","url":null,"abstract":"This review discusses the growing literature on the pathogenic role of IL-17 in cancer, focusing on recent studies that place IL-17 as a nexus linking inflammation, tissue repair, and cancer.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"80 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85312447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. F. du Pre, Jana Blaževski, Alisa E. Dewan, J. Stamnaes, Chakravarthi Kanduri, G. K. Sandve, M. K. Johannesen, Christian B Lindstad, Kathrin Hnida, L. Fugger, G. Melino, Shuo-Wang Qiao, L. Sollid
This study sheds light on the mechanism by which autoantibodies to transglutaminase 2 (TG2) are formed in celiac disease. The authors find that there is no deletion or silencing of autoreactive TG2-specific B cells and that production of anti-TG2 autoantibodies is controlled by T cell help.
{"title":"B cell tolerance and antibody production to the celiac disease autoantigen transglutaminase 2","authors":"M. F. du Pre, Jana Blaževski, Alisa E. Dewan, J. Stamnaes, Chakravarthi Kanduri, G. K. Sandve, M. K. Johannesen, Christian B Lindstad, Kathrin Hnida, L. Fugger, G. Melino, Shuo-Wang Qiao, L. Sollid","doi":"10.1084/jem.20190860","DOIUrl":"https://doi.org/10.1084/jem.20190860","url":null,"abstract":"This study sheds light on the mechanism by which autoantibodies to transglutaminase 2 (TG2) are formed in celiac disease. The authors find that there is no deletion or silencing of autoreactive TG2-specific B cells and that production of anti-TG2 autoantibodies is controlled by T cell help.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"130 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79588894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
IL-17 plays versatile roles during tumorigenesis. Here, Vitiello and Miller summarize current knowledge in harnessing IL-17–producing γδ and Th17 cells for successful cancer immunotherapy.
{"title":"Targeting the interleukin-17 immune axis for cancer immunotherapy","authors":"G. Vitiello, G. Miller","doi":"10.1084/jem.20190456","DOIUrl":"https://doi.org/10.1084/jem.20190456","url":null,"abstract":"IL-17 plays versatile roles during tumorigenesis. Here, Vitiello and Miller summarize current knowledge in harnessing IL-17–producing γδ and Th17 cells for successful cancer immunotherapy.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74064434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This review summarizes the steps from basic research on IL-17 family cytokines to understanding their role in psoriasis pathogenesis to the approval of a number of monoclonal antibodies targeting IL-17 pathways as first line treatment of psoriasis and psoriatic arthritis.
{"title":"Interleukin-17 cytokines: Effectors and targets in psoriasis—A breakthrough in understanding and treatment","authors":"I. Prinz, I. Sandrock, U. Mrowietz","doi":"10.1084/jem.20191397","DOIUrl":"https://doi.org/10.1084/jem.20191397","url":null,"abstract":"This review summarizes the steps from basic research on IL-17 family cytokines to understanding their role in psoriasis pathogenesis to the approval of a number of monoclonal antibodies targeting IL-17 pathways as first line treatment of psoriasis and psoriatic arthritis.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81608228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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