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Evaluation of extended depth-of-focus hydrophobic intraocular lens with an optic concept based on combination of high-order aberrations. 基于高阶像差组合的光学概念评估扩大焦深疏水性人工晶状体。
IF 2.5 Pub Date : 2023-10-03 eCollection Date: 2023-01-01 DOI: 10.1177/25158414231200108
Pavel Stodulka, Zuzana Pracharova

Background: Extended depth-of-focus (EDOF) intraocular lenses (IOLs) provide a continuous range of uncorrected vision at different distances.

Objective: To assess visual acuity, refractive outcomes, and patient satisfaction after cataract surgery using the LuxSmart EDOF IOL (Bausch+Lomb).

Design: A two-center, prospective observational clinical study.

Methods: This study includes patients who have undergone bilateral phacoemulsification with bilateral implantation of the LuxSmart EDOF IOL, with the aim of achieving emmetropia. Visual acuity (VA) and subjective refraction were obtained in all patients preoperatively and at 1 week, 1 month, 3 months, and 6 months postoperatively. Subjective measures were obtained using the Catquest-9SF questionnaire and the Patient-Reported Spectacle Independence Questionnaire (PRSIQ). Contrast sensitivity and a glare assessment were undertaken postoperatively. Safety outcomes were additionally assessed.

Results: Sixty eyes from thirty patients were recruited for this study. The mean spherical equivalent was 1.04 ± 1.67 D preoperatively and -0.30 ± 0.46 D at 6 months. Monocular uncorrected distance VA was 0.57 ± 0.32 (logMAR) preoperatively and 0.09 ± 0.12 (logMAR) at 6 months. Mean 6-month monocular uncorrected VA was 0.11 ± 0.13, 0.12 ± 0.15, and 0.31 ± 0.15 (logMAR) at 80, 66, and 40 cm, respectively. More than 90% of patients were either fairly or very satisfied with their vision. There was one case of suspected vitreomacular traction postoperatively.

Conclusion: The LuxSmart EDOF IOL offers good refractive, VA, and safety outcomes. The single elongated focal point designed to enhance the DOF shows good results for VA and patient satisfaction.

背景:扩展焦深(EDOF)人工晶状体(IOL)在不同距离提供连续范围的未矫正视力。目的:评估使用LuxSmart EDOF IOL(Bausch+Lomb)白内障手术后的视力、屈光结果和患者满意度。设计:一项双中心前瞻性观察性临床研究。方法:本研究包括接受双侧白内障超声乳化术并植入LuxSmart EDOF IOL的患者,目的是实现正视。所有患者在术前和术后1 周,1 月份,3 月和6 术后数月。使用Catquest-9SF问卷和患者报告的眼镜独立性问卷(PRSIQ)获得主观测量。术后进行对比敏感度和眩光评估。对安全性结果进行了额外评估。结果:本研究共招募了30名患者的60只眼睛。平均球形当量为1.04 ± 1.67 D术前和-0.30 ± 0.46 D在6 月。单眼未矫正距离VA为0.57 ± 术前0.32(logMAR)和0.09 ± 0.12(logMAR),6 月。平均6个月单眼未矫正VA为0.11 ± 0.130.12 ± 0.15和0.31 ± 80、66和40时为0.15(logMAR) 厘米。超过90%的患者对自己的视力相当或非常满意。术后有1例疑似玻璃体黄斑牵引。结论:LuxSmart EDOF IOL具有良好的屈光性、VA和安全性。设计用于增强DOF的单个细长焦点在VA和患者满意度方面显示出良好的效果。
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引用次数: 0
Ocular manifestations of COVID-19 in pediatric patients. COVID-19在儿童患者中的眼部表现。
IF 2.3 Q2 OPHTHALMOLOGY Pub Date : 2023-03-14 eCollection Date: 2023-01-01 DOI: 10.1177/25158414221149916
Parul Ichhpujani, Rohan Bir Singh, Hennaav Kaur Dhillon, Suresh Kumar

The coronavirus disease-19 (COVID-19) infection may remain asymptomatic or may have several different presentations. Although this disease primarily affects the respiratory system, systemic manifestations affecting the gastrointestinal, cardiovascular, neurological, otorhinolaryngologic, and ophthalmic systems have been reported. Ophthalmic signs may be the first and only sign of COVID-19 infection in children. In the current narrative review, we report the ophthalmic manifestations of COVID-19 in the pediatric age cohort. We performed a comprehensive literature search for the publications on ophthalmic manifestations of COVID-19 in children between 1 March 2020 and 1 January 2022 and compiled the ophthalmic manifestations of this entity among the pediatric population. Conjunctivitis is the most common ophthalmic manifestation in children and can develop at any stage of the disease. Ophthalmic manifestations are seen more commonly in children with severe systemic disease. Long-term and indirect consequence of the COVID-19 disease is the rise of myopia among children. Ophthalmic signs may be the first and only sign of COVID-19 infection in children. Pediatricians, as well as ophthalmologists, must keep observing all children with COVID-19 closely for ophthalmic signs.

冠状病毒病-19(COVID-19)感染可能没有症状,也可能有几种不同的表现。虽然这种疾病主要影响呼吸系统,但也有报道称会出现影响胃肠道、心血管、神经、耳鼻喉和眼科系统的全身表现。眼部症状可能是儿童感染 COVID-19 的第一个也是唯一的症状。在本综述中,我们报告了 COVID-19 在儿童中的眼部表现。我们对 2020 年 3 月 1 日至 2022 年 1 月 1 日期间发表的有关 COVID-19 儿童眼部表现的文献进行了全面检索,并整理了这一实体在儿科人群中的眼部表现。结膜炎是儿童最常见的眼部表现,可发生在疾病的任何阶段。眼部表现更常见于患有严重全身性疾病的儿童。COVID-19 疾病的长期间接后果是儿童近视率上升。眼部症状可能是儿童感染 COVID-19 的第一个也是唯一的迹象。儿科医生和眼科医生必须密切观察所有感染 COVID-19 的儿童的眼部症状。
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引用次数: 0
New insights into amiodarone induced retinal and optic nerve toxicity: functional and structural changes. 胺碘酮诱导视网膜和视神经毒性的新见解:功能和结构变化。
IF 2.5 Pub Date : 2023-01-01 DOI: 10.1177/25158414231194159
Weam Mohamed Ebeid, Amany Abd El-Fattah El-Shazly, Norhan Mohamed Kamal, Emad Effat Fakhary, Amr Mansour, Doaa Maamoun Ashour

Background: Amiodarone is widely used for heart arrhytmia. Previous studies have suggested the possibility of optic neuropathy with the chronic use of this drug.

Objectives: To identify structural or functional changes in the retina and optic nerve in patients on chronic amiodarone therapy without visual complaints.

Methods: This observational study included 15 eyes of 15 patients with cardiac arrythmia on chronic amiodarone treatment and 15 healthy matched subjects as a control group. All subjects underwent electrophysiological tests [pattern visual evoked potential (PVEP), pattern electroretinogram (PERG), multifocal electroretinogram (mfERG), and optical coherence tomography (OCT) and angiography (OCTA)].

Results: There were no statistically significant differences between the two groups regarding the PVEP, PERG, and the mfERG parameters. Macular and optic nerve head OCT and OCTA have not shown statistically significant differences except for the morphological parameters of the optic disc (p = 0.008 for the horizontal and p = 0.013 for vertical cup/disc ratio and p = 0.045 for rim area).

Conclusion: Patients on chronic amiodarone therapy have not shown evident structural or functional changes in the retinal or optic nerve as demonstrated by electrophysiological tests, OCT, and OCTA results compared to controls.

背景:胺碘酮被广泛用于治疗心律失常。以前的研究表明,视神经病变的可能性与长期使用这种药物。目的:探讨慢性胺碘酮治疗患者视网膜和视神经的结构或功能变化。方法:采用15例慢性胺碘酮治疗的心律失常患者的15只眼和15例健康配对者作为对照组。所有受试者都进行了电生理测试[模式视觉诱发电位(PVEP)、模式视网膜电图(PERG)、多焦视网膜电图(mfERG)、光学相干断层扫描(OCT)和血管造影(OCTA)]。结果:两组患者PVEP、PERG、mfERG参数比较,差异无统计学意义。黄斑和视神经头OCT与OCTA除视盘形态参数(水平杯盘比p = 0.008,垂直杯盘比p = 0.013,边缘面积p = 0.045)差异无统计学意义。结论:与对照组相比,接受慢性胺碘酮治疗的患者在电生理测试、OCT和OCTA结果中未显示出明显的视网膜或视神经结构或功能改变。
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引用次数: 0
Scheimpflug imaging for evaluation of intraocular lens position in modified flanged scleral fixated intraocular lens. 改良法兰巩膜固定人工晶状体中人工晶状体位置的评价。
IF 2.5 Pub Date : 2023-01-01 DOI: 10.1177/25158414221147208
Avadhesh Oli, Anil Yadav, J Ganesh Babu, Divya Balakrishnan

Background: Scleral fixation of intraocular lens (IOLs) is the most preferred technique for the management of aphakia and the techniques have evolved over the years. These methods have their advantages and disadvantages, however, the major concern being the position of the intraocular lens, its stability and complications. The final IOL position is the major determinant of the final visual acuity, and various imaging modalities have been used to quantify the IOL tilt.

Objectives: Use of Scheimpflug imaging to evaluate the IOL tilt in modified flanged scleral-fixated intraocular lens (MFSIOL).

Design: Retrospective chart review of 41 consecutive patients who underwent MFIOL.

Methods: We conducted a retrospective chart review of 41 consecutive patients who underwent MFIOL. The baseline and final best-corrected visual acuity (BCVA), refractive error, and clinical examination findings were recorded. The vertical and horizontal tilts of the IOLs were calculated using the Scheimpflug image. The IOL tilt (in degrees) in the vertical and horizontal axes was the primary outcome and the BCVA, residual refractive error, intraocular pressure, and surgical complications were secondary outcome measures.

Results: The mean baseline BCVA was logMAR 0.49, which improved to logMAR 0.356 (p < .005) after the surgery. The mean IOL tilt in the vertical axis was 3.40° (range of 0.0°-8.5°, interquartile range: 1.21-5.66) and in the horizontal axis was 1.35° (range of 0.60°-4.620°, interquartile range: 0.44-1.86), respectively. There was no correlation between angle of IOL tilt and UCVA (r = 0.089, p = 0.580), BCVA (r = 0.109, p = 0.498), final spherical error (r = 0.081, p = 0.615), cylindrical error (r = 0.207, p = 0.195), axial length (r = 0.105, p = 0.514), and IOL power (r = -0.139, p = 0.388).

Conclusion: Modified flanged IOL (MFIOL) is an alternative technique for intrascleral fixation of IOL resulting in good lens stability. The IOL tilt achieved by this technique is minimal and did not influence the final visual outcome or spectacle correction. Scheimpflug imaging is simple and non-invasive method to measure the IOL tilt.

Plain language summary scheimpflug imaging for modified flanged scleral fixated lens position: This study on 41 eyes was aimed to analyze the lens tilt using Scheimpflug imaging in cases of modified flanged scleral fixation of intraocular lens (MFSFIOL), which is a novel technique to minimize the complications and simplify the procedure. The intraocular lens (IOL) remained stable with an acceptable range of vertical and horizontal tilt. There was no significant effect of IOL tilt on the final best-corrected visual acuity (BCVA) or spectacle correction. Scheimpflug imaging is an accurate and non-invas

背景:人工晶状体巩膜固定术是治疗无晶状体的首选技术,该技术多年来不断发展。这些方法各有优缺点,但主要的问题是人工晶状体的位置、稳定性和并发症。最终的IOL位置是最终视力的主要决定因素,各种成像方式已被用于量化IOL倾斜。目的:应用Scheimpflug显像评价改良法兰巩膜固定人工晶状体(MFSIOL)的人工晶状体倾斜。设计:回顾性分析41例连续行MFIOL的患者。方法:我们对41例连续行MFIOL的患者进行回顾性分析。记录基线和最终最佳矫正视力(BCVA)、屈光不正和临床检查结果。使用Scheimpflug图像计算iol的垂直和水平倾斜。人工晶状体在垂直轴和水平轴上的倾斜度是主要观察指标,BCVA、残余屈光不正、眼压和手术并发症是次要观察指标。结果:平均基线BCVA为logMAR 0.49,分别提高至logMAR 0.356 (p r = 0.089, p = 0.580)、BCVA (r = 0.109, p = 0.498)、最终球面误差(r = 0.081, p = 0.615)、圆柱形误差(r = 0.207, p = 0.195)、轴向长度(r = 0.105, p = 0.514)、IOL度数(r = -0.139, p = 0.388)。结论:改良翼缘人工晶状体(MFIOL)是一种可选择的巩膜内人工晶状体固定技术,具有良好的晶状体稳定性。通过这种技术获得的IOL倾斜是最小的,并且不影响最终的视力结果或眼镜矫正。Scheimpflug成像是测量人工晶状体倾斜的一种简单、无创的方法。改良巩膜法兰固定晶状体位置的scheimpflug显像:本研究旨在分析改良巩膜法兰固定人工晶状体(MFSFIOL)病例中使用scheimpflug显像的晶状体倾斜情况,这是一种减少并发症和简化手术的新技术。人工晶状体(IOL)在可接受的垂直和水平倾斜范围内保持稳定。人工晶状体倾斜对最终最佳矫正视力(BCVA)和眼镜矫正无显著影响。Scheimpflug成像是一种准确且无创的技术,用于评估睫状体内固定患者的晶状体位置。
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引用次数: 0
Real-world efficacy of the intrascleral ciliary sulcus suprachoroidal microtube technique in Black and Afro-Latinx patients with glaucoma: a 1-year retrospective study. 巩膜睫状沟脉络膜上微管技术治疗黑人和拉丁裔青光眼患者的实际疗效:一项为期1年的回顾性研究。
IF 2.5 Pub Date : 2023-01-01 DOI: 10.1177/25158414221147445
Daniel Laroche, Gideon Nkrumah, Chester Ng
Background: Suprachoroidal surgery can lower intraocular pressure and medication use. There is currently no commercial suprachoroidal product on the market. Here, we report our 1 year results of a novel ciliary sulcus suprachoroidal microtube technique. Purpose: To determine the real-world efficacy of intrascleral ciliary sulcus suprachoroidal microtube technique in Black and Afro-Latinx patients with glaucoma refractory to topical ocular hypertensive medications. Methods: A retrospective non-comparative single center study of 36 Black and Afro-Latinx patients with glaucoma and pseudophakia who underwent intrascleral ciliary sulcus suprachoroidal microtube surgery for glaucoma as a stand-alone procedure at a single practice. Investigated parameters were number of medications, visual acuity (VA), intraocular pressure (IOP), mean deviation on visual field (VF) test. Success was defined as (a) IOP ⩽ 15 mmHg and or ⩾ 20% reduction in IOP and (b) a reduction in number of medications. We used paired t-test to compare baseline and follow-up parameters. Results: We reviewed a total of 36 patients who had undergone the procedure. Twenty had success with 12-month follow-up in the study. The mean number of medications decreased significantly from 4.2 ± 1.0 preoperatively to 2.4 ± 1.7 in 12 months (p = 0.021) with five patients being medication free. In addition, the IOP decreased significantly from 21 ± 8.2 to 13.5 ± 4.4 mmHg (p = 0.032). In the 20 patients who had 12-month follow-up, the VA remained stable from Log Mar 0.62 ± 0.6–0.46 ± 0.6 (p = 0.052). VF in patients with successful procedure (no further interventions) remained stable from baseline mean deviation of –16.53 ± 10.04 to –16.82 ± 9.80 dB at 6–12 months. Adverse effects were transient and included IOP spike, hypotony, hyphema, and cornea edema that were treated and resolved. Conclusions: This 12-month retrospective study demonstrated that intrascleral ciliary sulcus suprachoroidal microtube surgery can reduce IOP and medication burden in pseudophakic patients with glaucoma. However, despite several successes, surveillance should take place for IOP spikes, possible tube obstruction, and need for additional glaucoma surgery.
背景:脉络膜上手术可以降低眼压和药物使用。目前市场上还没有商业化的脉络膜上产品。在这里,我们报告了一种新的睫状沟脉络膜上微管技术1年的结果。目的:探讨巩膜睫状沟脉络膜上微管技术在黑人和非裔拉丁裔青光眼患者对局部高眼压药物治疗的实际疗效。方法:回顾性非比较单中心研究36例黑人和非裔拉丁人青光眼和假性晶状体患者,这些患者在一次单独手术中接受了巩膜睫状沟上微管手术治疗青光眼。研究参数为用药次数、视力(VA)、眼压(IOP)、视野平均偏差(VF)。成功被定义为(a) IOP≤15 mmHg和或小于或等于20% IOP降低和(b)药物数量减少。我们采用配对t检验比较基线和随访参数。结果:我们共回顾了36例接受该手术的患者。其中20人在12个月的随访中取得了成功。平均用药次数由术前4.2±1.0次减少至12个月后的2.4±1.7次(p = 0.021),其中5例患者为免用药。IOP由21±8.2 mmHg降至13.5±4.4 mmHg (p = 0.032)。在随访12个月的20例患者中,VA保持稳定在Log Mar 0.62±0.6-0.46±0.6 (p = 0.052)。手术成功(无进一步干预)患者的VF在6-12个月时保持稳定,基线平均偏差为-16.53±10.04至-16.82±9.80 dB。不良反应是短暂的,包括IOP尖峰、低眼压、前房积血和角膜水肿,这些都得到了治疗和解决。结论:这项为期12个月的回顾性研究表明,巩膜上睫状沟微管手术可降低青光眼假性晶状体患者的IOP和药物负担。然而,尽管取得了一些成功,仍应监测眼压峰值、可能的管梗阻以及是否需要进行额外的青光眼手术。
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引用次数: 1
A medication-wide association study to identify medications associated with incident clinically significant diabetic retinopathy. 一项全药物相关性研究,以确定与临床显著性糖尿病视网膜病变相关的药物。
IF 2.5 Pub Date : 2023-01-01 DOI: 10.1177/25158414221139002
Ruilin Xiong, Wei Wang, Xianwen Shang, Yixiong Yuan, Yifan Chen, Lei Zhang, Katerina V Kiburg, Zhuoting Zhu, Mingguang He

Background: Diabetic retinopathy, a common microvascular complication of diabetes mellitus, is one of the leading causes of vision loss worldwide. Although some oral drugs have been suggested to affect the risk of diabetic retinopathy, systematic evaluation about the associations between medications and diabetic retinopathy is still absent.

Objective: To comprehensively investigate associations of systemic medications with incident clinically significant diabetic retinopathy (CSDR).

Design: Population-based cohort study.

Methods: From 2006 to 2009, more than 26 000 participants residing in New South Wales were enrolled in the 45 and Up study. Diabetic participants with self-reported physician diagnosis or records of anti-diabetic medication prescriptions were finally included in the current analysis. CSDR was defined as diabetic retinopathy cases requiring retinal photocoagulation recorded in the Medicare Benefits Schedule database from 2006 to 2016. Prescriptions of systemic medication from 5 years to 30 days prior to CSDR were retrieved from the Pharmaceutical Benefits Scheme. The study participants were equally split into training and testing datasets. Logistic regression analyses were performed for the association between each of systemic medication and CSDR in the training dataset. After controlling the false discovery rate (FDR), significant associations were further validated in the testing dataset.

Results: The 10-year incidence of CSDR was 3.9% (n = 404). A total of 26 systemic medications were found to be positively associated with CSDR, among which 15 were validated by the testing dataset. Additional adjustments for pertinent comorbidities suggested that isosorbide mononitrate (ISMN) (OR: 1.87, 95%CI: 1.00-3.48), calcitriol (OR: 4.08, 95% CI: 2.02-8.24), three insulins and analogues (e.g., intermediate-acting human insulin, OR: 4.28, 95% CI: 1.69-10.8), five anti-hypertensive medications (e.g., furosemide, OR: 2.53, 95% CI: 1.77-3.61), fenofibrate (OR: 1.96, 95% CI: 1.36-2.82) and clopidogrel (OR: 1.72, 95% CI: 1.15-2.58) were independently associated with CSDR.

Conclusion: This study investigated the association of a full spectrum of systemic medications with incident CSDR. ISMN, calcitriol, clopidogrel, a few subtypes of insulin, anti-hypertensive and cholesterol-lowering medications were found to be associated with incident CSDR.

背景:糖尿病视网膜病变是糖尿病常见的微血管并发症,是世界范围内导致视力丧失的主要原因之一。虽然一些口服药物已被认为会影响糖尿病视网膜病变的风险,但关于药物与糖尿病视网膜病变之间关系的系统评估仍然缺乏。目的:全面探讨全身性药物治疗与临床显著性糖尿病视网膜病变(CSDR)的相关性。设计:基于人群的队列研究。方法:从2006年到2009年,居住在新南威尔士州的26000多名参与者参加了45岁及以上的研究。自我报告医生诊断或抗糖尿病药物处方记录的糖尿病参与者最终被纳入当前的分析。CSDR定义为2006年至2016年Medicare Benefits Schedule数据库中记录的需要视网膜光凝治疗的糖尿病视网膜病变病例。从药物福利计划中检索CSDR前5年至30天的全身用药处方。研究参与者平均分为训练数据集和测试数据集。对训练数据集中的系统性用药和CSDR之间的关联进行逻辑回归分析。在控制了错误发现率(FDR)后,在测试数据集中进一步验证了显著关联。结果:CSDR 10年发病率为3.9% (n = 404)。共发现26种全身性药物与CSDR呈正相关,其中15种通过测试数据集验证。对相关合并症的额外调整表明,单硝酸异山梨酯(ISMN) (OR: 1.87, 95%CI: 1.00-3.48)、骨化三醇(OR: 4.08, 95%CI: 2.02-8.24)、三种胰岛素及其类似物(例如,中效人胰岛素,OR: 4.28, 95%CI: 1.69-10.8)、五种抗高血压药物(例如,速尿,OR: 2.53, 95%CI: 1.77-3.61)、非诺贝特(OR: 1.96, 95%CI: 1.36-2.82)和氯吡格雷(OR: 1.72, 95%CI: 1.15-2.58)与CSDR独立相关。结论:本研究调查了全身性药物与CSDR事件的关系。ISMN、骨化三醇、氯吡格雷、几种亚型胰岛素、降压降胆固醇药物与CSDR的发生有关。
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引用次数: 0
Comparision of efficacy and safety of 0.03% and 0.1% tacrolimus ointment in children with vernal keratoconjunctivitis. 0.03%和0.1%他克莫司软膏治疗儿童春性角膜结膜炎的疗效和安全性比较。
IF 2.5 Pub Date : 2023-01-01 DOI: 10.1177/25158414231173532
Bhawesh Chandra Saha, Rashmi Kumari, Anita Ambasta

Background: Topical immunosuppressants such as tacrolimus in different concentrations are a breakthrough in the management of recalcitrant vernal keratoconjunctivitis (VKC); however, there is a lacks of comparative studies to guide their use in VKC management.

Objective: To compare the efficacy and safety of tacrolimus 0.03% and 0.1% eye ointment in the treatment of recalcitrant VKC.

Design: A retrospective comparative single-centre observational study.

Method: We reviewed records of a total of 48 recalcitrant VKC patients treated with two different strengths of tacrolimus ointment between April 2016 and March 2017. Of these, 39 fulfilled the inclusion criteria and were categorized into two groups, A and B, depending on the use of strength of tacrolimus (0.03% and 0.1%) used, respectively. Group A had 18 patients, while group B had 21 patients. Thirty-six patients, 18 from each group, were finally analysed and compared. Records of patients were explored for the subjective symptoms and objective sign score of the patient at baseline and at each time point. The main outcome measures were composite scoring and comparison of total subjective symptom scores (TSSSs) and total objective sign scores (TOSSs) within and between the groups at each follow-up. Percentage of patient with significant reduction in symptom and sign scores as compared with baseline was considered success of treatment. Chi-square and t-tests were used for comparison of outcomes between both groups.

Results: Mixed variety was most commonly encountered type of VKC. The signs and symptoms were significantly reduced in patients with treatment in both groups (p = 0.001) in all types of VKC. However, in group B, there was significant improvement in the size of papillae (p = 0.04) as compared baseline in contrast to group A. Side effects like burning and stinging in group B were significantly higher as compared with group A.

Conclusions: Both strengths of tacrolimus (0.03% and 0.1%) are effective in all forms of recalcitrant VKC. Papillary component of VKC responds better with higher strength (0.1%) but is associated with more significant side effects. Different strengths of tacrolimus can be used strategically depending upon the severity and clinical type of VKC to intensify outcome and minimize side effects.

背景:不同浓度的局部免疫抑制剂如他克莫司是治疗顽固性春性角膜结膜炎(VKC)的一个突破;然而,缺乏比较研究来指导它们在VKC管理中的应用。目的:比较0.03%他克莫司与0.1%他克莫司眼膏治疗顽固性VKC的疗效和安全性。设计:回顾性比较单中心观察性研究。方法:回顾2016年4月至2017年3月间使用两种不同剂量他克莫司软膏治疗的48例难治性VKC患者的记录。其中39例符合纳入标准,并根据他克莫司的使用强度(0.03%和0.1%)分别分为A组和B组。A组18例,B组21例。最后对36例患者进行分析比较,每组18例。记录患者在基线和各时间点的主观症状和客观体征评分。主要结局指标为每次随访时的综合评分和组内及组间主观症状总评分(TSSSs)和客观体征总评分(TSSSs)的比较。与基线相比,症状和体征评分显著降低的患者百分比被认为是治疗成功。两组结果比较采用卡方检验和t检验。结果:混合型是最常见的VKC类型。在所有类型的VKC中,两组患者在治疗后的体征和症状均显著减轻(p = 0.001)。然而,与a组相比,B组的乳头大小有显著改善(p = 0.04),与基线相比,B组的灼烧和刺痛等副作用明显高于a组。结论:他克莫司的两种强度(0.03%和0.1%)对所有形式的顽固性VKC都有效。VKC的乳头状成分反应较好,强度较高(0.1%),但副作用更明显。不同强度的他克莫司可根据VKC的严重程度和临床类型有策略地使用,以加强结果和减少副作用。
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引用次数: 2
Evaluating the safety and efficacy of epi-off corneal cross-linking in patients with thin corneas due to keratectasia. 评价肾上腺素-off角膜交联治疗角膜扩张性薄角膜患者的安全性和有效性。
IF 2.5 Pub Date : 2023-01-01 DOI: 10.1177/25158414231197064
Abigail Nieuwsma, Brandon L Vander Zee, John P Berdahl, Mitch Ibach, Tanner J Ferguson, Daniel Terveen

Background: Corneal cross-linking (CXL) is a safe and effective procedure for slowing keratectasia progression in eyes with a corneal thickness of at least 400 µm. Limited research has evaluated the safety and efficacy of epi-off CXL in corneas thinner than 400 µm.

Objective: To evaluate the safety and efficacy of CXL to slow keratectasia progression in eyes with <400 µm preoperative corneal thickness.

Design: Retrospective chart review.

Methods: This retrospective chart review included 37 eyes who underwent epi-off, iso-osmolar riboflavin corneal CXL with a preoperative thinnest point of the cornea <400 µm and had at least 6-12 months of follow-up. Preoperative and postoperative uncorrected visual acuity, best-corrected visual acuity (BCVA), thinnest point of the cornea, flat keratometry, steep keratometry, maximum keratometry (Kmax), need for penetrating keratoplasty, and cases of endothelial failure were recorded. Data were collected at baseline and months 3, 6, 9, and 12 post-CXL.

Results: Following cross-linking, 18 eyes (47%) had improved BCVA, 13 (35%) had an unchanged BCVA, and 6 eyes (16%) had a worse BCVA (p = 0.05). The mean postoperative BCVA was 20/81 (0.61 LogMAR) compared to 20/121 (0.78 LogMAR) preoperatively (p = 0.06). Kmax decreased an average of 1.1 D at 3-month (p = 0.53) and 3.4 D at the furthest follow-up (p = 0.10). At the farthest follow-up, 22.7% of eyes had >1 D of Kmax steepening. No patients required keratoplasty and there were no cases of endothelial failure in the follow-up period.

Conclusion: This research supports the safety and efficacy of epi-off, iso-osmolar CXL in eyes with <400 μm baseline corneal thickness with no patients requiring penetrating or endothelial keratoplasty, a trend toward improvement in BCVA, and Kmax flattening. In the future, prospective studies would be helpful to confirm these findings.

背景:角膜交联(CXL)是一种安全有效的治疗角膜厚度≥400µm的角膜扩张症的方法。有限的研究评估了epi-off CXL在角膜厚度小于400µm时的安全性和有效性。目的:评价CXL延缓眼部角膜扩张进展的安全性和有效性。方法:回顾性回顾了37只眼,这些眼接受了肾上腺素脱落、等渗核黄素角膜CXL(术前角膜最薄点为max)、穿透性角膜移植术和内皮细胞衰竭。在基线和cxl后3、6、9和12个月收集数据。结果:交联后,18只眼(47%)BCVA改善,13只眼(35%)BCVA不变,6只眼(16%)BCVA恶化(p = 0.05)。术后平均BCVA为20/81 (0.61 LogMAR),而术前为20/121 (0.78 LogMAR) (p = 0.06)。Kmax在3个月时平均下降1.1 D (p = 0.53),在最远随访时平均下降3.4 D (p = 0.10)。在最远的随访中,22.7%的眼睛有>1 D的Kmax变陡。在随访期间,没有患者需要角膜移植,也没有内皮细胞衰竭的病例。结论:本研究支持epi-off等渗透性CXL治疗最大扁平化眼的安全性和有效性。在未来,前瞻性研究将有助于证实这些发现。
{"title":"Evaluating the safety and efficacy of epi-off corneal cross-linking in patients with thin corneas due to keratectasia.","authors":"Abigail Nieuwsma,&nbsp;Brandon L Vander Zee,&nbsp;John P Berdahl,&nbsp;Mitch Ibach,&nbsp;Tanner J Ferguson,&nbsp;Daniel Terveen","doi":"10.1177/25158414231197064","DOIUrl":"https://doi.org/10.1177/25158414231197064","url":null,"abstract":"<p><strong>Background: </strong>Corneal cross-linking (CXL) is a safe and effective procedure for slowing keratectasia progression in eyes with a corneal thickness of at least 400 µm. Limited research has evaluated the safety and efficacy of epi-off CXL in corneas thinner than 400 µm.</p><p><strong>Objective: </strong>To evaluate the safety and efficacy of CXL to slow keratectasia progression in eyes with <400 µm preoperative corneal thickness.</p><p><strong>Design: </strong>Retrospective chart review.</p><p><strong>Methods: </strong>This retrospective chart review included 37 eyes who underwent epi-off, iso-osmolar riboflavin corneal CXL with a preoperative thinnest point of the cornea <400 µm and had at least 6-12 months of follow-up. Preoperative and postoperative uncorrected visual acuity, best-corrected visual acuity (BCVA), thinnest point of the cornea, flat keratometry, steep keratometry, maximum keratometry (K<sub>max</sub>), need for penetrating keratoplasty, and cases of endothelial failure were recorded. Data were collected at baseline and months 3, 6, 9, and 12 post-CXL.</p><p><strong>Results: </strong>Following cross-linking, 18 eyes (47%) had improved BCVA, 13 (35%) had an unchanged BCVA, and 6 eyes (16%) had a worse BCVA (<i>p</i> = 0.05). The mean postoperative BCVA was 20/81 (0.61 LogMAR) compared to 20/121 (0.78 LogMAR) preoperatively (<i>p</i> = 0.06). K<sub>max</sub> decreased an average of 1.1 D at 3-month (<i>p</i> = 0.53) and 3.4 D at the furthest follow-up (<i>p</i> = 0.10). At the farthest follow-up, 22.7% of eyes had >1 D of K<sub>max</sub> steepening. No patients required keratoplasty and there were no cases of endothelial failure in the follow-up period.</p><p><strong>Conclusion: </strong>This research supports the safety and efficacy of epi-off, iso-osmolar CXL in eyes with <400 μm baseline corneal thickness with no patients requiring penetrating or endothelial keratoplasty, a trend toward improvement in BCVA, and K<sub>max</sub> flattening. In the future, prospective studies would be helpful to confirm these findings.</p>","PeriodicalId":23054,"journal":{"name":"Therapeutic Advances in Ophthalmology","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/49/b5/10.1177_25158414231197064.PMC10504847.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10309626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of obesity on ocular hemodynamics and choroidal thickness. 肥胖对眼血流动力学和脉络膜厚度的影响。
IF 2.5 Pub Date : 2023-01-01 DOI: 10.1177/25158414231180985
Melek Tufek, Pinar Nalcacioglu, Mustafa Capraz, Kenan Varol, Ahmet Turan Kaya, Nihat Aydın, Caner Kara

Background: Obesity affects microvascular structures. The effect of obesity on the ocular vascular system can be evaluated by changes in the choroidal thickness (CT) and retrobulbar blood flow (RBF).

Objectives: To evaluate the CT and RBF parameters in obese patients with various body mass index (BMI) values and compare these parameters with normal weight, healthy subjects.

Design: A prospective study.

Methods: The study included 102 eyes of 102 female patients. Patients were divided into three groups according to BMI as group 1 with a BMI of 18.5-24.99 (n = 32), normal weight group; group 2 with a BMI of 30-34.99 (n = 35), as obese class I; and group 3 with a BMI of 35-39.99 (n = 35), as obese class II. The peak systolic velocity (PSV), end-diastolic velocity (EDV), resistive index, and pulsatility index values of the central retinal artery (CRA) and ophthalmic artery (OA) were evaluated with color Doppler ultrasonography. CT was measured at the subfoveal area and at 500-µm intervals nasal and temporal to the fovea up to a distance of 1500 µm by using the enhanced depth imaging technique of optical coherence tomography. Intraocular pressure (IOP) was measured with a Goldmann applanation tonometry.

Results: There was a significant difference in IOP values within the groups with the highest values in group 3 (17.6 ± 2.1 mmHg) and the lowest in group 1 (12.4 ± 1.7 mmHg). The CT in groups 2 and 3 was found to be statistically significantly lower than that in group 1 at all measurement points (p < 0.001). There was a statistically significant negative correlation between CT at all measurement points and BMI (p < 0.001). The mean CRA PSV, EDV, and OA EDV values were statistically significantly lower in each obese group than those values in group 1 (p < 0.001). The OA PSV values were significantly lower in group 3 (36.5 ± 5.9 cm/s) than those in group 2 (43.8 ± 4 cm/s) and group 1 (44.6 ± 5.2 cm/s) (p < 0.001). Also, significant associations were found between BMI and CRA PSV, CRA EDV, and OA PSV values (p < 0.001).

Conclusion: Obesity may predispose to eye pathologies by changing the ocular vascular circulation.

背景:肥胖影响微血管结构。肥胖对眼血管系统的影响可以通过脉络膜厚度(CT)和球后血流(RBF)的变化来评估。目的:评价不同体重指数(BMI)的肥胖患者的CT和RBF参数,并与体重正常的健康人进行比较。设计:前瞻性研究。方法:对102例女性患者的102只眼进行研究。根据BMI将患者分为3组:1组BMI为18.5 ~ 24.99 (n = 32),体重正常组;2组BMI为30 ~ 34.99 (n = 35),为肥胖I级;第三组BMI为35 ~ 39.99 (n = 35),为肥胖II类。彩色多普勒超声检查视网膜中央动脉(CRA)和眼动脉(OA)的峰值收缩速度(PSV)、舒张末期速度(EDV)、阻力指数和脉搏指数。采用光学相干断层成像增强深度成像技术,在中央凹下区域和鼻腔、颞部至中央凹间隔500µm至1500µm处进行CT测量。眼压(IOP)用Goldmann眼压计测量。结果:两组间IOP值差异有统计学意义,3组最高(17.6±2.1 mmHg), 1组最低(12.4±1.7 mmHg)。2、3组CT各测点均低于1组,差异有统计学意义(p p p p p p)。结论:肥胖可通过改变眼部血管循环诱发眼部病变。
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引用次数: 2
A cross-sectional study investigating the effects of argon laser retinal photocoagulation on lens clarity and corneal endothelial cells. 横断面研究氩激光视网膜光凝对晶状体清晰度和角膜内皮细胞的影响。
IF 2.5 Pub Date : 2023-01-01 DOI: 10.1177/25158414231189071
Uğur Yılmaz, Hüseyin Kaya, Selen Akbulut, Yasin Durkal

Background: The mechanism of argon laser retinal photocoagulation (ALRP) treatment is to apply thermal-induced retinal pigment epithelium damage. Light passes through the anterior optical segments of the eye to reach the retina. Lens densitometry is a noninvasive and quantitative measurement providing information about corneal and lens clarity.

Objectives: This study aimed to investigate whether laser light affects lens clarity and corneal endothelial cells.

Design: This was a prospective, cross-sectional study.

Methods: Lens densitometric (LD) analysis and specular microscopy were performed before, after, and 1 month after ALRP treatment, by an expert ophthalmologist, blinded to the medical status of the patients. LD analysis was performed using a Pentacam HR (Oculus, Wetzlar, Germany) and a Specular Microscope CEM-530 (Nidek, Japan) was used for endothelial cell analysis.

Results: The evaluation was made on 81 eyes of 41 patients, with a mean age of 54.46 ± 6.7 years. LD, after ALRP, was significantly more than before ALRP (p < 0.001). There was no statistically significant difference in LD, before ALRP, and 1 month after ALRP (p = 0.262). There was a statistically significant increase in LD after ALRP compared to before ALRP, but it decreased after 1 month. There was an increase in the coefficient of variance (CV) after ALRP compared to before ALRP but it was not statistically significant (p = 0.188). There was no statistically significant difference in CV between before ALRP and 1 month after ALRP (p = 1.000). There was no statistically significant difference in the cell density, the hexagonality percentage between before ALRP, after ALRP, and 1 month after ALRP (p = 0.993, and 0.863, respectively).

Conclusion: ALRP may affect the lens densitometry temporarily during the procedure. Thermal damage may be the reason for increased lens densitometry.

背景:氩激光视网膜光凝(ALRP)治疗的机制是利用热致视网膜色素上皮损伤。光线通过眼睛的前光学部分到达视网膜。晶状体密度测定法是一种非侵入性的定量测量方法,可提供角膜和晶状体清晰度的信息。目的:探讨激光对晶状体清晰度和角膜内皮细胞的影响。设计:这是一项前瞻性横断面研究。方法:在不了解患者身体状况的情况下,由眼科专家在ALRP治疗前、治疗后和治疗后1个月进行晶状体密度分析和镜面显微镜检查。LD分析使用Pentacam HR (Oculus, Wetzlar, Germany)和镜面显微镜CEM-530 (Nidek, Japan)进行内皮细胞分析。结果:41例患者共81只眼,平均年龄54.46±6.7岁。术后LD显著高于术前(p p = 0.262)。与ALRP前相比,ALRP后LD有统计学意义的增加,但在1个月后下降。与ALRP前相比,ALRP后的方差系数(CV)有所增加,但差异无统计学意义(p = 0.188)。术前与术后1个月的CV差异无统计学意义(p = 1.000)。细胞密度、六边形百分率与术前、术后及术后1个月比较差异均无统计学意义(p = 0.993、0.863)。结论:ALRP可能会暂时影响晶状体密度测定。热损伤可能是晶状体密度增加的原因。
{"title":"A cross-sectional study investigating the effects of argon laser retinal photocoagulation on lens clarity and corneal endothelial cells.","authors":"Uğur Yılmaz,&nbsp;Hüseyin Kaya,&nbsp;Selen Akbulut,&nbsp;Yasin Durkal","doi":"10.1177/25158414231189071","DOIUrl":"https://doi.org/10.1177/25158414231189071","url":null,"abstract":"<p><strong>Background: </strong>The mechanism of argon laser retinal photocoagulation (ALRP) treatment is to apply thermal-induced retinal pigment epithelium damage. Light passes through the anterior optical segments of the eye to reach the retina. Lens densitometry is a noninvasive and quantitative measurement providing information about corneal and lens clarity.</p><p><strong>Objectives: </strong>This study aimed to investigate whether laser light affects lens clarity and corneal endothelial cells.</p><p><strong>Design: </strong>This was a prospective, cross-sectional study.</p><p><strong>Methods: </strong>Lens densitometric (LD) analysis and specular microscopy were performed before, after, and 1 month after ALRP treatment, by an expert ophthalmologist, blinded to the medical status of the patients. LD analysis was performed using a Pentacam HR (Oculus, Wetzlar, Germany) and a Specular Microscope CEM-530 (Nidek, Japan) was used for endothelial cell analysis.</p><p><strong>Results: </strong>The evaluation was made on 81 eyes of 41 patients, with a mean age of 54.46 ± 6.7 years. LD, after ALRP, was significantly more than before ALRP (<i>p</i> < 0.001). There was no statistically significant difference in LD, before ALRP, and 1 month after ALRP (<i>p</i> = 0.262). There was a statistically significant increase in LD after ALRP compared to before ALRP, but it decreased after 1 month. There was an increase in the coefficient of variance (CV) after ALRP compared to before ALRP but it was not statistically significant (<i>p</i> = 0.188). There was no statistically significant difference in CV between before ALRP and 1 month after ALRP (<i>p</i> = 1.000). There was no statistically significant difference in the cell density, the hexagonality percentage between before ALRP, after ALRP, and 1 month after ALRP (<i>p</i> = 0.993, and 0.863, respectively).</p><p><strong>Conclusion: </strong>ALRP may affect the lens densitometry temporarily during the procedure. Thermal damage may be the reason for increased lens densitometry.</p>","PeriodicalId":23054,"journal":{"name":"Therapeutic Advances in Ophthalmology","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/98/4f/10.1177_25158414231189071.PMC10395167.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10295619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Therapeutic Advances in Ophthalmology
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