Pub Date : 2021-02-07DOI: 10.1080/02772248.2021.1951731
Shanshan Wang, Hufei Wang, Yanqiu Chen, Jilai Liu, Xiaozheng He, Da Huang, Yuanzi Wu, Y. Chen, Zuquan Weng
Abstract Human lymphocytes as well as zebrafish embryos were used to study the toxicity of acrylamide, and the intervention effects of the dietary antioxidants (-)-epigallocatechin gallate and curcumin have been examined. The alkaline comet assay revealed that acrylamide (1, 5, 10 mmol/L) had dose-response effects on basic DNA damage and oxidative DNA damage in human lymphocytes. Exposure of zebrafish embryos to acrylamide resulted in decrease of hatching rate, and in increases of mortality and teratogenicity. (-)-Epigallocatechin gallate and curcumin reduced DNA damage and protected zebrafish embryos in the growth and development.
{"title":"Protective effects of (-)-epigallocatechin gallate and curcumin against acrylamide toxicity","authors":"Shanshan Wang, Hufei Wang, Yanqiu Chen, Jilai Liu, Xiaozheng He, Da Huang, Yuanzi Wu, Y. Chen, Zuquan Weng","doi":"10.1080/02772248.2021.1951731","DOIUrl":"https://doi.org/10.1080/02772248.2021.1951731","url":null,"abstract":"Abstract Human lymphocytes as well as zebrafish embryos were used to study the toxicity of acrylamide, and the intervention effects of the dietary antioxidants (-)-epigallocatechin gallate and curcumin have been examined. The alkaline comet assay revealed that acrylamide (1, 5, 10 mmol/L) had dose-response effects on basic DNA damage and oxidative DNA damage in human lymphocytes. Exposure of zebrafish embryos to acrylamide resulted in decrease of hatching rate, and in increases of mortality and teratogenicity. (-)-Epigallocatechin gallate and curcumin reduced DNA damage and protected zebrafish embryos in the growth and development.","PeriodicalId":23210,"journal":{"name":"Toxicological & Environmental Chemistry","volume":"1 1","pages":"199 - 218"},"PeriodicalIF":0.0,"publicationDate":"2021-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82578013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-07DOI: 10.1080/02772248.2021.1947278
Sanusi Babangida, A. Muhammad, A. Garba, A. Sallau
Abstract Hexavalent chromium has been widely distributed in the environment by natural and anthropogenic sources characterized by higher toxicological and solubility properties than the trivalent form. Remediation-by-reduction of chromium (VI) to chromium (III) through the use of chemicals has offered an environmental and cost-effective approach for chromate detoxification. One of the major disadvantages of chemical reduction is that the addition of reductant constitutes a secondary source of contamination; for instance, sodium dithionite at low pH can decompose to sulfur dioxide which can irritate the skin and respiratory tract. In this review, the application of safer reductants of conventional and nanotechnological approaches is addressed. The use of antioxidant biomaterials for chromium (VI) remediation may offer benign alternatives to the use of chemical reductants.
{"title":"Antioxidants in bioremediation of chromium (VI) by conventional and nanotechnological approaches: a review","authors":"Sanusi Babangida, A. Muhammad, A. Garba, A. Sallau","doi":"10.1080/02772248.2021.1947278","DOIUrl":"https://doi.org/10.1080/02772248.2021.1947278","url":null,"abstract":"Abstract Hexavalent chromium has been widely distributed in the environment by natural and anthropogenic sources characterized by higher toxicological and solubility properties than the trivalent form. Remediation-by-reduction of chromium (VI) to chromium (III) through the use of chemicals has offered an environmental and cost-effective approach for chromate detoxification. One of the major disadvantages of chemical reduction is that the addition of reductant constitutes a secondary source of contamination; for instance, sodium dithionite at low pH can decompose to sulfur dioxide which can irritate the skin and respiratory tract. In this review, the application of safer reductants of conventional and nanotechnological approaches is addressed. The use of antioxidant biomaterials for chromium (VI) remediation may offer benign alternatives to the use of chemical reductants.","PeriodicalId":23210,"journal":{"name":"Toxicological & Environmental Chemistry","volume":"76 1","pages":"162 - 183"},"PeriodicalIF":0.0,"publicationDate":"2021-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77854149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-02DOI: 10.1080/02772248.2020.1869742
K. Priya, Sruthy G. S., H. S, A. S., Brema J.
Abstract This discussion paper looks into the COVID-19 induced lockdown on the air quality of the five most polluted cities in India. There were significant reductions in the concentrations of particulate matter, ≤ 2.5 µm and ≤ 10 µm, NO2, and CO during lockdown compared to that in 2019. Even then, the levels of particulate matter never reached the target specified by the World Health Organization. There was an increase in the concentrations of O3 at some cities, which may be attributed to the alterations in the photo-stationary cycle due to change in the concentration of nitrogen oxides and volatile organic carbons.
{"title":"Air quality in five major cities of India induced by the COVID-19 pandemic lockdown","authors":"K. Priya, Sruthy G. S., H. S, A. S., Brema J.","doi":"10.1080/02772248.2020.1869742","DOIUrl":"https://doi.org/10.1080/02772248.2020.1869742","url":null,"abstract":"Abstract This discussion paper looks into the COVID-19 induced lockdown on the air quality of the five most polluted cities in India. There were significant reductions in the concentrations of particulate matter, ≤ 2.5 µm and ≤ 10 µm, NO2, and CO during lockdown compared to that in 2019. Even then, the levels of particulate matter never reached the target specified by the World Health Organization. There was an increase in the concentrations of O3 at some cities, which may be attributed to the alterations in the photo-stationary cycle due to change in the concentration of nitrogen oxides and volatile organic carbons.","PeriodicalId":23210,"journal":{"name":"Toxicological & Environmental Chemistry","volume":"34 1","pages":"50 - 55"},"PeriodicalIF":0.0,"publicationDate":"2021-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75833687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-02DOI: 10.1080/02772248.2021.1879083
Jeonghyun Hong, Jisue Kim, R. Selvaraj, Younghun Kim
Abstract In the case of wastewater treatment, many researche’s are mainly focused on nanopowder-type photocatalysts that have high efficiency because of their good dispersibility and high specific surface area. Ironically, these properties of nanopowder photocatalysts cause some drawbacks in their recovery from treated water, making practical applications in wastewater treatment difficult. The use of a three dimensional based-ceramic fiber as a substrate and graphitic carbon nitride (g-C3N4) as a visible-light-driven photocatalyst can be a promising approach to overcome the above-mentioned limitations. This study describes the immobilization of g-C3N4 on ceramic fiber using a facile co-calcination method and verifies its photodegradation activity under visible light. The recovery efficiency, physicochemical stability of samples, and the potential of the practical application of wastewater treatment were tested with organic dye decomposition experiments under visible light irradiation.
{"title":"Immobilization of visible-light-driven photocatalyst g-C3N4 on ceramic fiber for degradation of organic dye","authors":"Jeonghyun Hong, Jisue Kim, R. Selvaraj, Younghun Kim","doi":"10.1080/02772248.2021.1879083","DOIUrl":"https://doi.org/10.1080/02772248.2021.1879083","url":null,"abstract":"Abstract In the case of wastewater treatment, many researche’s are mainly focused on nanopowder-type photocatalysts that have high efficiency because of their good dispersibility and high specific surface area. Ironically, these properties of nanopowder photocatalysts cause some drawbacks in their recovery from treated water, making practical applications in wastewater treatment difficult. The use of a three dimensional based-ceramic fiber as a substrate and graphitic carbon nitride (g-C3N4) as a visible-light-driven photocatalyst can be a promising approach to overcome the above-mentioned limitations. This study describes the immobilization of g-C3N4 on ceramic fiber using a facile co-calcination method and verifies its photodegradation activity under visible light. The recovery efficiency, physicochemical stability of samples, and the potential of the practical application of wastewater treatment were tested with organic dye decomposition experiments under visible light irradiation.","PeriodicalId":23210,"journal":{"name":"Toxicological & Environmental Chemistry","volume":"13 1","pages":"18 - 36"},"PeriodicalIF":0.0,"publicationDate":"2021-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90523825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-02DOI: 10.1080/02772248.2020.1856380
Zahra Abpeikar, Roohollah Mohseni, M. Safaei
Abstract The article presents a hypothesis on a co-delivery strategy to suppress or reduce infection caused by the COVID-19 virus. Co-delivery was illustrated in many diseases, and results showed that it produced a high therapeutic efficacy against disorders. We proposed an approach to suppress or reduce infection caused by the coronavirus disease 2019 via designing an intelligent nano-liposome loaded with interferon γ, interleukin 4 and small interfering RNA against vimentin. At the surface of this nanostructure, there is a matrix metallopeptidase3 substrate to provide a platform for the enzymatic function of matrix metallopeptidase3 to destroy the extracellular matrix, angiotensin-converting enzyme 2 blocker, and antibody against vimentin for targeting, trans-activator of transcription peptide, and polyethylene glycol. Due to the increasing application of nano-liposomes commercially as a drug-delivery system, it is important to consider this effective approach for the coronavirus disease 2019 treatment. Graphical Abstract
{"title":"The multifunctional nano-immunoliposome design: hypothesis on a therapeutic approach for COVID-19","authors":"Zahra Abpeikar, Roohollah Mohseni, M. Safaei","doi":"10.1080/02772248.2020.1856380","DOIUrl":"https://doi.org/10.1080/02772248.2020.1856380","url":null,"abstract":"Abstract The article presents a hypothesis on a co-delivery strategy to suppress or reduce infection caused by the COVID-19 virus. Co-delivery was illustrated in many diseases, and results showed that it produced a high therapeutic efficacy against disorders. We proposed an approach to suppress or reduce infection caused by the coronavirus disease 2019 via designing an intelligent nano-liposome loaded with interferon γ, interleukin 4 and small interfering RNA against vimentin. At the surface of this nanostructure, there is a matrix metallopeptidase3 substrate to provide a platform for the enzymatic function of matrix metallopeptidase3 to destroy the extracellular matrix, angiotensin-converting enzyme 2 blocker, and antibody against vimentin for targeting, trans-activator of transcription peptide, and polyethylene glycol. Due to the increasing application of nano-liposomes commercially as a drug-delivery system, it is important to consider this effective approach for the coronavirus disease 2019 treatment. Graphical Abstract","PeriodicalId":23210,"journal":{"name":"Toxicological & Environmental Chemistry","volume":"72 1","pages":"119 - 125"},"PeriodicalIF":0.0,"publicationDate":"2021-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91384358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-02DOI: 10.1080/02772248.2021.1880176
A. Rettenmeier
1. SARS-CoV-2 uses, among other things, the membrane-integrated ACE2 to enter the cell. Thus, ACE2 is a functional receptor for the virus. 2. Controlling or reducing the activity of this receptor (and of vimentin, a coreceptor) helps to influence the viral infection. 3. There is evidence that hypertension treatment with ACE inhibitors and angiotensin II receptor blockers (ARBs) causes an increased expression of ACE2. This leads to the hypothesis that patients treated with ACE inhibitors or ARBs may have an increased risk of SARS-CoV-2 infections or, in the case of infection, a worse prognosis. 4. The treatment of Vero E6 cells infected with the earlier SARS-CoV with IFNc and IL4 resulted in the down-regulation of ACE2. 5. The ACE2 inhibitor on the liposomes is needed to target the infected cells equipped with ACE2 receptors. 6. IFNc and IL4 should be used to neutralize the harmful increase in expression of ACE2 on the target cells caused by the ACE2 inhibitor on the liposomes.
{"title":"Comments of the reviewer to letter of Zahra Abpeikar, Roohollah Mohseni & Mohsen Safaei: ‘The multifunctional nano-immunoliposome design: hypothesis on a therapeutic approach for COVID-19’","authors":"A. Rettenmeier","doi":"10.1080/02772248.2021.1880176","DOIUrl":"https://doi.org/10.1080/02772248.2021.1880176","url":null,"abstract":"1. SARS-CoV-2 uses, among other things, the membrane-integrated ACE2 to enter the cell. Thus, ACE2 is a functional receptor for the virus. 2. Controlling or reducing the activity of this receptor (and of vimentin, a coreceptor) helps to influence the viral infection. 3. There is evidence that hypertension treatment with ACE inhibitors and angiotensin II receptor blockers (ARBs) causes an increased expression of ACE2. This leads to the hypothesis that patients treated with ACE inhibitors or ARBs may have an increased risk of SARS-CoV-2 infections or, in the case of infection, a worse prognosis. 4. The treatment of Vero E6 cells infected with the earlier SARS-CoV with IFNc and IL4 resulted in the down-regulation of ACE2. 5. The ACE2 inhibitor on the liposomes is needed to target the infected cells equipped with ACE2 receptors. 6. IFNc and IL4 should be used to neutralize the harmful increase in expression of ACE2 on the target cells caused by the ACE2 inhibitor on the liposomes.","PeriodicalId":23210,"journal":{"name":"Toxicological & Environmental Chemistry","volume":"58 1","pages":"126 - 127"},"PeriodicalIF":0.0,"publicationDate":"2021-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86977301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-02DOI: 10.1080/02772248.2021.1892113
E. Nikkhah, Kobra Shirani, R. Rezaee, G. Karimi
Abstract The liver plays a central role in metabolism, so excessive exposure to drugs and other xenobiotics may result in hepatotoxicity. A protective effect of taurine, a conditionally essential amino acid, against hepatotoxicity induced by chemicals has been shown in vivo and in vitro. In this review, data available from such studies about the hepatoprotective effects of taurine are presented and possible mechanisms of action are discussed. The reviewed literature suggests that taurine inhibits oxidative stress and inflammation, induces conjugation of xenobiotics with bile acids, stabilizes cell membranes, controls hepatic glutathione contents, and suppresses certain cytochrome isozymes, all indicating anti-apoptotic, antioxidant, and osmoregulatory properties of taurine.
{"title":"Protective effects of taurine against hepatotoxicity induced by pharmaceuticals and environmental chemicals","authors":"E. Nikkhah, Kobra Shirani, R. Rezaee, G. Karimi","doi":"10.1080/02772248.2021.1892113","DOIUrl":"https://doi.org/10.1080/02772248.2021.1892113","url":null,"abstract":"Abstract The liver plays a central role in metabolism, so excessive exposure to drugs and other xenobiotics may result in hepatotoxicity. A protective effect of taurine, a conditionally essential amino acid, against hepatotoxicity induced by chemicals has been shown in vivo and in vitro. In this review, data available from such studies about the hepatoprotective effects of taurine are presented and possible mechanisms of action are discussed. The reviewed literature suggests that taurine inhibits oxidative stress and inflammation, induces conjugation of xenobiotics with bile acids, stabilizes cell membranes, controls hepatic glutathione contents, and suppresses certain cytochrome isozymes, all indicating anti-apoptotic, antioxidant, and osmoregulatory properties of taurine.","PeriodicalId":23210,"journal":{"name":"Toxicological & Environmental Chemistry","volume":"20 1","pages":"56 - 84"},"PeriodicalIF":0.0,"publicationDate":"2021-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72641058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-02DOI: 10.1080/02772248.2021.1872574
Ignacio Barrales, D. Hernández-Moreno, L. Fidalgo, A. López-Beceiro, S. Martínez-Morcillo, L. Sánchez-Montero, María Prado Míguez, F. Soler, M. Pérez-López
Abstract Zinc, cadmium, and lead in livers, kidneys, and feathers of 48 young and adult Atlantic puffins found dead or dying off the coast of Galicia (Northwest Spain) were determined. The most abundant between the three elements was the essential metal zinc, with highest mean levels (173 ± 9 mg/kg dry weight) in livers. For the two non-essential metals, the highest mean levels of cadmium were found in kidneys (22.1 ± 1.0 mg/kg dry weight), and of lead in feathers (1.31 ± 0.10 mg/kg dry weight). For some birds, concentrations of zinc and cadmium exceeded established risk levels. The concentrations of the three metals were positively correlated in livers. In kidneys and livers, cadmium levels were correlated. With respect to age, the levels of the three metals in adults were higher than in young animals. Female birds showed significantly higher levels than males. The results are useful for establishing baseline data of the concentrations of the three metals for this species. Graphical Abstract
{"title":"Levels of zinc, cadmium, and lead in liver, kidney, and feathers of Atlantic puffins (Fratercula arctica) from Spain","authors":"Ignacio Barrales, D. Hernández-Moreno, L. Fidalgo, A. López-Beceiro, S. Martínez-Morcillo, L. Sánchez-Montero, María Prado Míguez, F. Soler, M. Pérez-López","doi":"10.1080/02772248.2021.1872574","DOIUrl":"https://doi.org/10.1080/02772248.2021.1872574","url":null,"abstract":"Abstract Zinc, cadmium, and lead in livers, kidneys, and feathers of 48 young and adult Atlantic puffins found dead or dying off the coast of Galicia (Northwest Spain) were determined. The most abundant between the three elements was the essential metal zinc, with highest mean levels (173 ± 9 mg/kg dry weight) in livers. For the two non-essential metals, the highest mean levels of cadmium were found in kidneys (22.1 ± 1.0 mg/kg dry weight), and of lead in feathers (1.31 ± 0.10 mg/kg dry weight). For some birds, concentrations of zinc and cadmium exceeded established risk levels. The concentrations of the three metals were positively correlated in livers. In kidneys and livers, cadmium levels were correlated. With respect to age, the levels of the three metals in adults were higher than in young animals. Female birds showed significantly higher levels than males. The results are useful for establishing baseline data of the concentrations of the three metals for this species. Graphical Abstract","PeriodicalId":23210,"journal":{"name":"Toxicological & Environmental Chemistry","volume":"79 1","pages":"104 - 118"},"PeriodicalIF":0.0,"publicationDate":"2021-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84096980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-02DOI: 10.1080/02772248.2021.1882460
A. Atıcı
Abstract Morali, Akkopru, and Kurbas Rivers are rivers flowing into Van Lake passing through the highly populated Van City, Turkey. They carry domestic and industrial wastewater to Van Lake. For assessment of the environmental load from these rivers to the lake, a sampling investigation from October 2019 to September 2020 was carried out. Chemical oxygen demand, biochemical oxygen demand, and nitrogenous compound levels were also examined. Linear alkylbenzene sulfonates ranged up to 0.40 mg L−1 (Kurubas River), the mean phosphate was 0.96 mg L−1, and the mean boron 1.2 mg L−1. According to Turkish surface water quality regulations, while Morali and Akkopru Rivers were determined as class II (less contaminated), Kurubas River was found as class III (polluted).
莫拉利河、阿克科普鲁河和库尔巴斯河是流经土耳其人口稠密的凡城，流入凡湖的河流。它们将家庭和工业废水输送到凡湖。为评估这些河流对湖泊的环境负荷，于2019年10月至2020年9月进行了抽样调查。化学需氧量、生化需氧量和氮化合物水平也进行了检测。线性烷基苯磺酸盐最高可达0.40 mg L - 1(库鲁巴斯河)，平均磷酸盐为0.96 mg L - 1，平均硼为1.2 mg L - 1。根据土耳其地表水质量规定，莫拉利河和阿克科普鲁河被定为II类(污染程度较低)，库鲁巴斯河被定为III类(污染)。
{"title":"Seasonal changes of some detergent components in surface water of rivers to the Van Lake, Turkey","authors":"A. Atıcı","doi":"10.1080/02772248.2021.1882460","DOIUrl":"https://doi.org/10.1080/02772248.2021.1882460","url":null,"abstract":"Abstract Morali, Akkopru, and Kurbas Rivers are rivers flowing into Van Lake passing through the highly populated Van City, Turkey. They carry domestic and industrial wastewater to Van Lake. For assessment of the environmental load from these rivers to the lake, a sampling investigation from October 2019 to September 2020 was carried out. Chemical oxygen demand, biochemical oxygen demand, and nitrogenous compound levels were also examined. Linear alkylbenzene sulfonates ranged up to 0.40 mg L−1 (Kurubas River), the mean phosphate was 0.96 mg L−1, and the mean boron 1.2 mg L−1. According to Turkish surface water quality regulations, while Morali and Akkopru Rivers were determined as class II (less contaminated), Kurubas River was found as class III (polluted).","PeriodicalId":23210,"journal":{"name":"Toxicological & Environmental Chemistry","volume":"40 1","pages":"37 - 49"},"PeriodicalIF":0.0,"publicationDate":"2021-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73003302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-02DOI: 10.1080/02772248.2021.1892112
A. Nezami, B. Daraei, K. razavi-Azarkhiavi, M. Amirahmadi, J. Feizy, A. Hayes, J. Giesy, G. Karimi
Abstract A rapid, simple and accurate extraction QuEChERS method was used for simultaneous determination of 22 hormones with a wide range of polarities in 35 infant formulae by use of LC–ESI-MS/MS. In the present method, some changes were made compared to other methods, which include eliminating the enzymatic hydrolysis step, derivatization and performing analysis a wide range of analytes with different polarities in single run. Three validation runs based on three levels of pre-extraction spiked quality control samples were conducted. Limits of detection obtained by use of the QuEChERS methods were less than those of other extraction methods with the same matrix and recoveries were more satisfactory. Under optimal experimental conditions, good linearity was observed in the range of 1–50 µg L−1. Limits of detection and quantification were in the range of 0.33–1.66 µg L−1 and 1–5 µg L−1, respectively and recoveries of analytes ranged from 73 to 118%. The amount of hormone residues in the samples was not significant. The present method is proposed for routine analysis of hormones potentially present in infant formula and other milk-derived products.
{"title":"Optimization of QuEChERS extraction of steroid hormones from infant formulae for mass spectrometric analysis","authors":"A. Nezami, B. Daraei, K. razavi-Azarkhiavi, M. Amirahmadi, J. Feizy, A. Hayes, J. Giesy, G. Karimi","doi":"10.1080/02772248.2021.1892112","DOIUrl":"https://doi.org/10.1080/02772248.2021.1892112","url":null,"abstract":"Abstract A rapid, simple and accurate extraction QuEChERS method was used for simultaneous determination of 22 hormones with a wide range of polarities in 35 infant formulae by use of LC–ESI-MS/MS. In the present method, some changes were made compared to other methods, which include eliminating the enzymatic hydrolysis step, derivatization and performing analysis a wide range of analytes with different polarities in single run. Three validation runs based on three levels of pre-extraction spiked quality control samples were conducted. Limits of detection obtained by use of the QuEChERS methods were less than those of other extraction methods with the same matrix and recoveries were more satisfactory. Under optimal experimental conditions, good linearity was observed in the range of 1–50 µg L−1. Limits of detection and quantification were in the range of 0.33–1.66 µg L−1 and 1–5 µg L−1, respectively and recoveries of analytes ranged from 73 to 118%. The amount of hormone residues in the samples was not significant. The present method is proposed for routine analysis of hormones potentially present in infant formula and other milk-derived products.","PeriodicalId":23210,"journal":{"name":"Toxicological & Environmental Chemistry","volume":"45 1","pages":"1 - 17"},"PeriodicalIF":0.0,"publicationDate":"2021-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75936067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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