J. González-Canudas, Luis Jesús García-Aguirre, Araceli G. Medina-Nolasco, María Isabel Ruíz-Olmedo, Liz Janet Medina Reyes, Lucia Zambrano Tapia, Yulia Romero-Antonio, A. Molina-Pérez, A. G. Amador-Hernández
This single-center, single-blind, randomized, 2-period, 2-treatment, crossover, single-dose-per-period, 2-sequence study evaluated the bioequivalence of a test dexketoprofen-trometamol (oral solution) compared with a reference 25 mg dexketoprofen-trometamol in 27 healthy adults under fasting conditions. Blood samples were collected pre-dose and at specified intervals across an 8-hour period following administration and were analyzed for dexketoprofen-trometamol using a validated reverse-phase high-performance liquid chromatography method. Drug products were considered to be bioequivalent if confidence intervals of natural log-transformed Cmax, AUC0-t, and AUC0-∞ data were within the range of 80-125%. Results showed an earlier Cmax which might traduce in faster onset of action for solution formulation. However, criteria for bioequivalence were met for AUC0-t, and AUC0-∞. All measured dexketoprofen-trometamol concentrations in this study were within a safe therapeutic range, and no adverse events were reported. *Correspondence to: Jorge González Canudas, Av. Paseo de las Palmas, #340, Third Floor, Col. Lomas de Chapultepec, Alcaldía Miguel Hidalgo, C.P. 11000, Mexico, Tel: 5254883761; E-mail: jogonzalez@silanes.com.mx
这项单中心、单盲、随机、2期、2治疗、交叉、每期单剂量、2序列的研究评估了27名健康成人在禁食条件下dexketoprofen-trometamol(口服溶液)试验与dexketoprofen-trometamol (25mg)对照的生物等效性。在给药后的8小时内，在给药前和指定的时间间隔内采集血液样本，并使用有效的反相高效液相色谱法分析dexketoprofen-trometamol。如果自然对数变换的Cmax、AUC0-t和AUC0-∞数据的置信区间在80-125%范围内，则认为药品具有生物等效性。结果表明，Cmax较早，这可能会导致溶液配方的起效更快。但AUC0-t和AUC0-∞均满足生物等效性标准。本研究中所有测量的dexketoprofen-trometamol浓度均在安全治疗范围内，无不良事件报告。*通信地址:Jorge González Canudas, Av. Paseo de las Palmas, 3楼340号，Col. Lomas de Chapultepec, Alcaldía Miguel Hidalgo, cp . 11000，墨西哥，电话:5254883761;电子邮件:jogonzalez@silanes.com.mx
{"title":"Bioequivalence evaluation of two oral formulations of Dexketoprofen-trometamol (solution and tablets) in healthy subjects: Results from a randomized, single-blind, crossover study","authors":"J. González-Canudas, Luis Jesús García-Aguirre, Araceli G. Medina-Nolasco, María Isabel Ruíz-Olmedo, Liz Janet Medina Reyes, Lucia Zambrano Tapia, Yulia Romero-Antonio, A. Molina-Pérez, A. G. Amador-Hernández","doi":"10.15761/TIM.1000176","DOIUrl":"https://doi.org/10.15761/TIM.1000176","url":null,"abstract":"This single-center, single-blind, randomized, 2-period, 2-treatment, crossover, single-dose-per-period, 2-sequence study evaluated the bioequivalence of a test dexketoprofen-trometamol (oral solution) compared with a reference 25 mg dexketoprofen-trometamol in 27 healthy adults under fasting conditions. Blood samples were collected pre-dose and at specified intervals across an 8-hour period following administration and were analyzed for dexketoprofen-trometamol using a validated reverse-phase high-performance liquid chromatography method. Drug products were considered to be bioequivalent if confidence intervals of natural log-transformed Cmax, AUC0-t, and AUC0-∞ data were within the range of 80-125%. Results showed an earlier Cmax which might traduce in faster onset of action for solution formulation. However, criteria for bioequivalence were met for AUC0-t, and AUC0-∞. All measured dexketoprofen-trometamol concentrations in this study were within a safe therapeutic range, and no adverse events were reported. *Correspondence to: Jorge González Canudas, Av. Paseo de las Palmas, #340, Third Floor, Col. Lomas de Chapultepec, Alcaldía Miguel Hidalgo, C.P. 11000, Mexico, Tel: 5254883761; E-mail: jogonzalez@silanes.com.mx","PeriodicalId":23337,"journal":{"name":"Trends in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82599603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Received: June 27, 2019; Accepted: July 18, 2019; Published: July 22, 2019 Heart failure represents an important cause of morbidity and mortality worldwide. Despite recent advances in the treatment of this condition, majority of patients have a bad prognosis, low functional class and poor quality of life. Recent guidelines have approved new drugs for the management of these patients and many others are under investigation. ENTRESTO, a combination of sacubritil/valsartan and ivabradine reduce the risk of cardiovascular mortality in patients with heart failure with reduced ejection fraction and are recommended in patients who maintain symptomatic despite concomitant use of angiotensin-converting enzyme inhibitors, beta-blockers and aldosterone antagonists [1,2].
{"title":"Digoxin use in patients with heart failure with reduced ejection fraction","authors":"Y. Castro-Torres","doi":"10.15761/tim.1000201","DOIUrl":"https://doi.org/10.15761/tim.1000201","url":null,"abstract":"Received: June 27, 2019; Accepted: July 18, 2019; Published: July 22, 2019 Heart failure represents an important cause of morbidity and mortality worldwide. Despite recent advances in the treatment of this condition, majority of patients have a bad prognosis, low functional class and poor quality of life. Recent guidelines have approved new drugs for the management of these patients and many others are under investigation. ENTRESTO, a combination of sacubritil/valsartan and ivabradine reduce the risk of cardiovascular mortality in patients with heart failure with reduced ejection fraction and are recommended in patients who maintain symptomatic despite concomitant use of angiotensin-converting enzyme inhibitors, beta-blockers and aldosterone antagonists [1,2].","PeriodicalId":23337,"journal":{"name":"Trends in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79122393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Haemodialysis patients usually have symptoms of either mentally or physically experienced before or during or after their procedure. This study evaluates the frequency of experienced symptoms, negatively effect of functioning, regardless of acuity, and well-being can be measured in terms of bio physiological parameters as BP, Pulse rate, Respiratory rate and SpO2. Methods: In this study convenience sampling technique was used to correlate the symptom experiences and bio-physiological parameters of 200 hemodialysis patients using one to one interview with the set of framed symptoms. Results: During AV Fistula cannulation, the major symptoms seen were fear, anxiety, irritation, anger and sadness. The main physical symptom experiences by HD patients was pain, drowsiness, fatigue, headache, palpitations, numbness, nausea/vomiting and, breathlessness. There was increase in pulse rate, blood pressure, heart rate, and decrease in the respiratory rate in majority of patients. The most relevant and highly significant were pulse rate due to fear and irritation and increase in hear rate and respiration due to pain and breathlessness. Conclusion: This study suggests that nursing and physicians’ team should consider reducing problems of haemodialysis patients by training and counselling. More is warranted to improve the quality of life which can be resulted from exercise counselling and encouragement in hemodialysis patients. *Correspondence to: R Revathi, MSc (N), PhD, Assistant Professor, Faculty of Nursing, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai-600116, India, E-mail: revathisriraghu@yahoo.co.in
{"title":"Association between symptom experiences with bio-physiological parameters of haemodialysis patients during AV-fistula cannulation","authors":"R. K., Nalini Sj, R. R.","doi":"10.15761/TIM.1000174","DOIUrl":"https://doi.org/10.15761/TIM.1000174","url":null,"abstract":"Background: Haemodialysis patients usually have symptoms of either mentally or physically experienced before or during or after their procedure. This study evaluates the frequency of experienced symptoms, negatively effect of functioning, regardless of acuity, and well-being can be measured in terms of bio physiological parameters as BP, Pulse rate, Respiratory rate and SpO2. Methods: In this study convenience sampling technique was used to correlate the symptom experiences and bio-physiological parameters of 200 hemodialysis patients using one to one interview with the set of framed symptoms. Results: During AV Fistula cannulation, the major symptoms seen were fear, anxiety, irritation, anger and sadness. The main physical symptom experiences by HD patients was pain, drowsiness, fatigue, headache, palpitations, numbness, nausea/vomiting and, breathlessness. There was increase in pulse rate, blood pressure, heart rate, and decrease in the respiratory rate in majority of patients. The most relevant and highly significant were pulse rate due to fear and irritation and increase in hear rate and respiration due to pain and breathlessness. Conclusion: This study suggests that nursing and physicians’ team should consider reducing problems of haemodialysis patients by training and counselling. More is warranted to improve the quality of life which can be resulted from exercise counselling and encouragement in hemodialysis patients. *Correspondence to: R Revathi, MSc (N), PhD, Assistant Professor, Faculty of Nursing, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai-600116, India, E-mail: revathisriraghu@yahoo.co.in","PeriodicalId":23337,"journal":{"name":"Trends in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83986087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Korovessis, Vasileios Vitsas, V. Syrimpeis, V. Tsekouras
Study design: A cross-sectional study Summary and background data: Both Scoliometer and Debrunner’s Kyphometer are validated and widely accepted as surface non-invasive, non-radiating measurement instruments for school screening programs for detection and measurement of scoliosis, thoracic kyphosis and lumbar lordosis. Objectives of the study: The authors have questioned if the prevalence of scoliosis and its distribution among gender and spinal levels has changed in the last 20 years; and if the additional measurement of sagittal spinal curvatures is of great importance just like the scoliosis is. Methods: This cross-sectional observational study was conducted in 2016 in a randomly selected school population in a metropolitan town in the south-western Europe. In 897 adolescents, aged 12-14 years the authors measured both coronal and sagittal spinal curvatures using the scoliometer to measure scoliosis and the Debrunner kyphometer to measure thoracic kyphosis and lumbar lordosis. Previously validated mathematical formulae were used to estimate with high accuracy the predicted Cobb angle. Leg discrepancy was evaluated and correlated with scoliosis. Results: The reliability of measurement with the Debrunner’s kyphometer and Scoliometer was high. There were 124 (13.8%) subjects with scoliosis curve-ATR/ value of ≥2o. The 99.94% were single-level curves, and 0.06% double curves. The right thoracic curve was the most frequent (49%), followed by the right thoracolumbar (19%); left lumbar (12%); left thoracic (8%); right lumbar (6%) and left thoracolumbar (6%). Girls showed higher prevalence than boys in right thoracic (P=0.009) and right thoracolumbar (P= 0.014) curves. In contrary, in 53 subjects (40 girls, 13 boys) with ATR>5o: no significant gender-related difference and right to left side localization of scoliosis was disclosed; there were 4 (7.5%) individuals with right thoracic ATR: 9 (17%) with left thoracic; 13 (25%) right thoracolumbar; 4 (7.5%) left thoracolumbar; 2 (4%) right lumbar and 10 (19%) left lumbar. There was a statistically significant positive correlation between right lumbar ATR and ipsilateral leg shortening (P=0.000). These findings are within previous similar school screening reports in this country in the last 20 years. Thoracic kyphosis increases linearly with lumbar lordosis. Boys showed greater thoracic kyphosis and less lumbar lordosis than girls. Fourteen (0.15%) individuals with Kyphometer values ≥55o were sent for radiological examination. Fifty three (5.9%) subjects (3.2% boys and 8.2% girls) with ATR ≥5° were sent for radiological examination. Conclusions: The authors recommend to physicians engaged in scoliosis screening programs to use the Debrunner Kyphometer and Scoliometer together with the mathematic formulas for accurate Cobb angle measurement. We believe that this method will reduce the cost of school screening programs, the over diagnosis, and the unnecessary exposure to radiation of young population in the
{"title":"Evolution observation of coronal and sagittal spinal curvatures in school children with non-invasive, non-radiating methods: Scoliometer and Debrunner Kyphometer","authors":"P. Korovessis, Vasileios Vitsas, V. Syrimpeis, V. Tsekouras","doi":"10.15761/tim.1000180","DOIUrl":"https://doi.org/10.15761/tim.1000180","url":null,"abstract":"Study design: A cross-sectional study Summary and background data: Both Scoliometer and Debrunner’s Kyphometer are validated and widely accepted as surface non-invasive, non-radiating measurement instruments for school screening programs for detection and measurement of scoliosis, thoracic kyphosis and lumbar lordosis. Objectives of the study: The authors have questioned if the prevalence of scoliosis and its distribution among gender and spinal levels has changed in the last 20 years; and if the additional measurement of sagittal spinal curvatures is of great importance just like the scoliosis is. Methods: This cross-sectional observational study was conducted in 2016 in a randomly selected school population in a metropolitan town in the south-western Europe. In 897 adolescents, aged 12-14 years the authors measured both coronal and sagittal spinal curvatures using the scoliometer to measure scoliosis and the Debrunner kyphometer to measure thoracic kyphosis and lumbar lordosis. Previously validated mathematical formulae were used to estimate with high accuracy the predicted Cobb angle. Leg discrepancy was evaluated and correlated with scoliosis. Results: The reliability of measurement with the Debrunner’s kyphometer and Scoliometer was high. There were 124 (13.8%) subjects with scoliosis curve-ATR/ value of ≥2o. The 99.94% were single-level curves, and 0.06% double curves. The right thoracic curve was the most frequent (49%), followed by the right thoracolumbar (19%); left lumbar (12%); left thoracic (8%); right lumbar (6%) and left thoracolumbar (6%). Girls showed higher prevalence than boys in right thoracic (P=0.009) and right thoracolumbar (P= 0.014) curves. In contrary, in 53 subjects (40 girls, 13 boys) with ATR>5o: no significant gender-related difference and right to left side localization of scoliosis was disclosed; there were 4 (7.5%) individuals with right thoracic ATR: 9 (17%) with left thoracic; 13 (25%) right thoracolumbar; 4 (7.5%) left thoracolumbar; 2 (4%) right lumbar and 10 (19%) left lumbar. There was a statistically significant positive correlation between right lumbar ATR and ipsilateral leg shortening (P=0.000). These findings are within previous similar school screening reports in this country in the last 20 years. Thoracic kyphosis increases linearly with lumbar lordosis. Boys showed greater thoracic kyphosis and less lumbar lordosis than girls. Fourteen (0.15%) individuals with Kyphometer values ≥55o were sent for radiological examination. Fifty three (5.9%) subjects (3.2% boys and 8.2% girls) with ATR ≥5° were sent for radiological examination. Conclusions: The authors recommend to physicians engaged in scoliosis screening programs to use the Debrunner Kyphometer and Scoliometer together with the mathematic formulas for accurate Cobb angle measurement. We believe that this method will reduce the cost of school screening programs, the over diagnosis, and the unnecessary exposure to radiation of young population in the ","PeriodicalId":23337,"journal":{"name":"Trends in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91474174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marie Garmier-Billard, J. DeFelice, F. Soler, J. Iwaz, R. Écochard
Objective: Assess quantitatively the impact of nocturnal light pollution on the menstrual cycle. Design: Cross-sectional observational study. Setting: Single French institute from November 2017 to March 2018. Participants: Nineteen ostensibly healthy menstruating women aged 19 to 45, inclusive Intervention(s): None Main outcome measures: Assessment of nocturnal light pollution (questionnaire and lux meter) and 22 clinical signs of ovulation disorder. Wilcoxon tests were used to quantify the abilities of nocturnal light pollution factors to predict clinical signs of ovulation disorders. Results: Nearly half of the 94 daily observations made by questionnaire and measurements made by lux meter indicated light pollution due to light flooding into the bedroom from indoor or outdoor sources. Nearly more than half of the 56 menstrual cycles presented at least mild abnormalities. The data showed that some clinical signs of ovulation disorders may be significantly predicted by factors of light pollution but a lack of power prevented reaching Bonferroni criterion. Conclusions: The indications of negative impact of dim light at night on some menstrual cycle characteristics call for a randomized study to quantify improvements of menstrual cycle characteristics brought by suppressing nocturnal light pollution. This will pave the way for new therapeutic perspectives for some difficult cases of ovulation disorders.
{"title":"Nocturnal light pollution and clinical signs of ovulation disorders","authors":"Marie Garmier-Billard, J. DeFelice, F. Soler, J. Iwaz, R. Écochard","doi":"10.15761/TIM.1000193","DOIUrl":"https://doi.org/10.15761/TIM.1000193","url":null,"abstract":"Objective: Assess quantitatively the impact of nocturnal light pollution on the menstrual cycle. Design: Cross-sectional observational study. Setting: Single French institute from November 2017 to March 2018. Participants: Nineteen ostensibly healthy menstruating women aged 19 to 45, inclusive Intervention(s): None Main outcome measures: Assessment of nocturnal light pollution (questionnaire and lux meter) and 22 clinical signs of ovulation disorder. Wilcoxon tests were used to quantify the abilities of nocturnal light pollution factors to predict clinical signs of ovulation disorders. Results: Nearly half of the 94 daily observations made by questionnaire and measurements made by lux meter indicated light pollution due to light flooding into the bedroom from indoor or outdoor sources. Nearly more than half of the 56 menstrual cycles presented at least mild abnormalities. The data showed that some clinical signs of ovulation disorders may be significantly predicted by factors of light pollution but a lack of power prevented reaching Bonferroni criterion. Conclusions: The indications of negative impact of dim light at night on some menstrual cycle characteristics call for a randomized study to quantify improvements of menstrual cycle characteristics brought by suppressing nocturnal light pollution. This will pave the way for new therapeutic perspectives for some difficult cases of ovulation disorders.","PeriodicalId":23337,"journal":{"name":"Trends in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87012724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Soft tissue infection in surgery is rapidly progressive infection that caused by variety of bacteria and their exotoxins that ultimately lead to extensive damage and necrosis of deep tissue and fascia. When it occurs in susceptible patients it led to septicemia and septic shock. It occurs mainly in scrotum, pernium and lower limbs and among malnutrition debilitated person. The disease is of high mortality rate. Early identification using is important to unwanted surgical consequence. Aim of study: To focus on the cause and diagnosis of serious soft tissue infection using laboratory investigations. Material and method: The study include (626) patients, (378) male and (248), Age (19-67) years. The study was done in department of General surgery in Al –Ramadi hospital ( July 2008-July 2018). Samples of the study was collected from patients come to hospital suffered from Necrotizing fasciitis. These patients undergoing clinical, radiographical examination and laboratory investigations. Samples of tissue are collected for bacterial culture and send to laboratory for bacterial identification and antibiotic sensitivity. X-ray and CT were used for examination of the area. Blood samples were also collected and send to laboratory for complete blood examination. Results: The statistical results indicate that the severe cases is associated with lowest mean value of WBC (7.1806±1.95788), and lowest mean value of hemoglobin (6.9260±2.25653) and highest serum level of creatinine (145.9758±2.33841), glucose (13.8547±1.71067) and lowest serum sodium (94.0986±.22220) in comparison with control group. The mean difference is significant at 0.05 level (P<0.05). Conclusion: Necrotising soft tissue infection is a serious fatal condition. Focusing on the cause of such condition of is important to start the early treatment to avoid the mortality. *Correspondence to: Liqaa Shallal Farhan, M.Sc, B.D.S, Maxillofacial Surgery, Dentistry College, Anbar University, Iraq, E-mail: liqaa.shallal@gmail.com
{"title":"Diagnostic parameters used in detecting of serious surgical soft tissue infection: Necrotizing fasciitis","authors":"L. Farhan","doi":"10.15761/tim.1000189","DOIUrl":"https://doi.org/10.15761/tim.1000189","url":null,"abstract":"Soft tissue infection in surgery is rapidly progressive infection that caused by variety of bacteria and their exotoxins that ultimately lead to extensive damage and necrosis of deep tissue and fascia. When it occurs in susceptible patients it led to septicemia and septic shock. It occurs mainly in scrotum, pernium and lower limbs and among malnutrition debilitated person. The disease is of high mortality rate. Early identification using is important to unwanted surgical consequence. Aim of study: To focus on the cause and diagnosis of serious soft tissue infection using laboratory investigations. Material and method: The study include (626) patients, (378) male and (248), Age (19-67) years. The study was done in department of General surgery in Al –Ramadi hospital ( July 2008-July 2018). Samples of the study was collected from patients come to hospital suffered from Necrotizing fasciitis. These patients undergoing clinical, radiographical examination and laboratory investigations. Samples of tissue are collected for bacterial culture and send to laboratory for bacterial identification and antibiotic sensitivity. X-ray and CT were used for examination of the area. Blood samples were also collected and send to laboratory for complete blood examination. Results: The statistical results indicate that the severe cases is associated with lowest mean value of WBC (7.1806±1.95788), and lowest mean value of hemoglobin (6.9260±2.25653) and highest serum level of creatinine (145.9758±2.33841), glucose (13.8547±1.71067) and lowest serum sodium (94.0986±.22220) in comparison with control group. The mean difference is significant at 0.05 level (P<0.05). Conclusion: Necrotising soft tissue infection is a serious fatal condition. Focusing on the cause of such condition of is important to start the early treatment to avoid the mortality. *Correspondence to: Liqaa Shallal Farhan, M.Sc, B.D.S, Maxillofacial Surgery, Dentistry College, Anbar University, Iraq, E-mail: liqaa.shallal@gmail.com","PeriodicalId":23337,"journal":{"name":"Trends in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76299920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sohrab Aghabeigi, M. Ranjbar, Fatemah Tahanian, Ahmad Hezarjaribi
Background: WHIM syndrome is a rare primary immunodeficiency disorder. WHIM is an acronym for some of the characteristic symptoms of the disorder; warts, hypogammaglobulinemia, infections, and myelokathexis. Case-report: A 23-year-old male with a history of recurrent cutaneous and respiratory tract infections -since early childhoodwas presented with chronic productive cough, fever, pleuritic chest pain, chills and sweating. Preclinical investigation showed leukopenia, neutropenia, myelokathexis and hypogammaglobulinemia. Patient was diagnosed for WHIM syndrome he also had a positive HBs Ag with normal LFT tests. He was treated with Ciprofloxacin, Vancomycin and IVIG but due to withdrawing the next sessions of IVIG; he was admitted 2 more times with respiratory tract infection and pneumonia that was treated with antibiotics and IVIG again and was discharged with good condition. He is on monthly IVIG and tenofovir because of being HBs Ag positive. Conclusion: This case report provides data of a patient with recurrent respiratory and cutaneous infection who was diagnosed with WHIM syndrome and had a positive Hbs Ag However, his liver function test was normal. *Correspondence to: Sohrab Aghabeigi, MD, Department of Internal Medicine, Iran University of Medical Sciences, Tehran, Iran. E-mail: doctorsohrabaghabeigi@gmail.com
{"title":"A case report of a congenital immune deficiency disease –WHIM syndrome","authors":"Sohrab Aghabeigi, M. Ranjbar, Fatemah Tahanian, Ahmad Hezarjaribi","doi":"10.15761/tim.1000214","DOIUrl":"https://doi.org/10.15761/tim.1000214","url":null,"abstract":"Background: WHIM syndrome is a rare primary immunodeficiency disorder. WHIM is an acronym for some of the characteristic symptoms of the disorder; warts, hypogammaglobulinemia, infections, and myelokathexis. Case-report: A 23-year-old male with a history of recurrent cutaneous and respiratory tract infections -since early childhoodwas presented with chronic productive cough, fever, pleuritic chest pain, chills and sweating. Preclinical investigation showed leukopenia, neutropenia, myelokathexis and hypogammaglobulinemia. Patient was diagnosed for WHIM syndrome he also had a positive HBs Ag with normal LFT tests. He was treated with Ciprofloxacin, Vancomycin and IVIG but due to withdrawing the next sessions of IVIG; he was admitted 2 more times with respiratory tract infection and pneumonia that was treated with antibiotics and IVIG again and was discharged with good condition. He is on monthly IVIG and tenofovir because of being HBs Ag positive. Conclusion: This case report provides data of a patient with recurrent respiratory and cutaneous infection who was diagnosed with WHIM syndrome and had a positive Hbs Ag However, his liver function test was normal. *Correspondence to: Sohrab Aghabeigi, MD, Department of Internal Medicine, Iran University of Medical Sciences, Tehran, Iran. E-mail: doctorsohrabaghabeigi@gmail.com","PeriodicalId":23337,"journal":{"name":"Trends in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89651946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Knowledge of breast cancer patterns over time allows a better understanding of the disease, with benefits for research and treatment improvement. This study analyses the evolution of epidemiological and pathological patterns in premenopausal breast cancer over two decades. Material and methods: Medical records from premenopausal breast cancer patients in our department were analysed. Two comparison groups over time were established: group A (1995-1998) and B (2008-2011). Results: Group A included 105 patients and group B 282, revealing an increasing incidence. A significant increase in patient age at diagnosis, age at first pregnancy, breastfeeding and hormonal contraception lifespan were observed, as well as a significant decrease in age of menarche. Imagiological diagnosis increased over time, resulting in an earlier stage disease. Surgical treatment has become predominantly conservative and hormone therapy has increased markedly. Overall prognosis was improved, followed by a significant decrease in recurrence and mortality rates. Conclusion: From 1995 to 2011, significant changes are reported in premenopausal breast cancer in women, which reflects the enormous and significant improvement in healthcare. point and the skill of the enumerator. The information included demographic characteristics–age, ethnicity and body mass index; gynecologic and obstetric data–age of menarche, length of use of hormonal contraception, parity, age at first pregnancy and breastfeeding; clinical characteristics of the tumour–palpable/non-palpable and stage (TNM); histopathological features–tumour type, tumour grade, lymph node status, oestrogen and progesterone receptors (ER and PR), and HER2 receptors status; therapeutic protocols; mortality and recurrence rate.
{"title":"Trends of breast cancer in premenopausal women over two decades","authors":"A. Pais, S. Subtil, M. Figueiredo-Dias","doi":"10.15761/TIM.1000187","DOIUrl":"https://doi.org/10.15761/TIM.1000187","url":null,"abstract":"Objective: Knowledge of breast cancer patterns over time allows a better understanding of the disease, with benefits for research and treatment improvement. This study analyses the evolution of epidemiological and pathological patterns in premenopausal breast cancer over two decades. Material and methods: Medical records from premenopausal breast cancer patients in our department were analysed. Two comparison groups over time were established: group A (1995-1998) and B (2008-2011). Results: Group A included 105 patients and group B 282, revealing an increasing incidence. A significant increase in patient age at diagnosis, age at first pregnancy, breastfeeding and hormonal contraception lifespan were observed, as well as a significant decrease in age of menarche. Imagiological diagnosis increased over time, resulting in an earlier stage disease. Surgical treatment has become predominantly conservative and hormone therapy has increased markedly. Overall prognosis was improved, followed by a significant decrease in recurrence and mortality rates. Conclusion: From 1995 to 2011, significant changes are reported in premenopausal breast cancer in women, which reflects the enormous and significant improvement in healthcare. point and the skill of the enumerator. The information included demographic characteristics–age, ethnicity and body mass index; gynecologic and obstetric data–age of menarche, length of use of hormonal contraception, parity, age at first pregnancy and breastfeeding; clinical characteristics of the tumour–palpable/non-palpable and stage (TNM); histopathological features–tumour type, tumour grade, lymph node status, oestrogen and progesterone receptors (ER and PR), and HER2 receptors status; therapeutic protocols; mortality and recurrence rate.","PeriodicalId":23337,"journal":{"name":"Trends in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91052573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Núñez Viejo, C. Areses Manrique, L. Iglesias Rey, Antonio Iglesias Rey, Antonio Javier Jiménez López, Ana Cabezón Álvarez, Begoña Soler López
{"title":"Quantification of quality of life improvement after appropriate symptoms control in cancer patients with breakthrough pain: A four-week follow-up study in a palliative care unit","authors":"M. Núñez Viejo, C. Areses Manrique, L. Iglesias Rey, Antonio Iglesias Rey, Antonio Javier Jiménez López, Ana Cabezón Álvarez, Begoña Soler López","doi":"10.15761/tim.1000198","DOIUrl":"https://doi.org/10.15761/tim.1000198","url":null,"abstract":"","PeriodicalId":23337,"journal":{"name":"Trends in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85100533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This review on amyloidosis aims to give a simple and concise practical paper on the vast and complex theme that is amyloidosis. Research has done using PubMed with the terms “amyloid” and “amyloidosis” and selecting review articles. The references of the selected articles were also analysis for more appropriated information. This review methodically makes an overview of the main aspects of the disease (incidence, pathogenesis, clinical features, diagnosis and treatment). This is an expanding field that affects a lot of different specialties and is an important pathology that still needs investigation on the diverse causes, as well as in new therapeutic targets and available therapies. *Correspondence to: Liliana Pedro, Departmenf of Medicine 3, Algarve University Hospital Center, Portimão, Portugal, ABCAlgarve Biomedical Center, Faro, Portugal, E-mail: lilianapedro7@gmail.com
{"title":"Amyloidosis – A review","authors":"Liliana Pedro, Raquel Pinho, N. Marques","doi":"10.15761/tim.1000206","DOIUrl":"https://doi.org/10.15761/tim.1000206","url":null,"abstract":"This review on amyloidosis aims to give a simple and concise practical paper on the vast and complex theme that is amyloidosis. Research has done using PubMed with the terms “amyloid” and “amyloidosis” and selecting review articles. The references of the selected articles were also analysis for more appropriated information. This review methodically makes an overview of the main aspects of the disease (incidence, pathogenesis, clinical features, diagnosis and treatment). This is an expanding field that affects a lot of different specialties and is an important pathology that still needs investigation on the diverse causes, as well as in new therapeutic targets and available therapies. *Correspondence to: Liliana Pedro, Departmenf of Medicine 3, Algarve University Hospital Center, Portimão, Portugal, ABCAlgarve Biomedical Center, Faro, Portugal, E-mail: lilianapedro7@gmail.com","PeriodicalId":23337,"journal":{"name":"Trends in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87595115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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