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Formulation and Evaluation of Triamcinolone Acetonide-loaded Oral Disintegrated Film with Different Polymers via Solvent Casting Method 不同聚合物载曲安奈德口腔崩解膜的溶剂铸造法制备及评价
Pub Date : 2023-11-14 DOI: 10.4274/tjps.galenos.2023.37807
Özlem Çoban, Kutsal Özcan, Seçkin Engin, Buse Tatar, Mihriban Soylu
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引用次数: 0
Ultrasound- and Vortex-Assisted Dispersive Liquid-Liquid Microextraction of Parabens from Personal Care Products and Urine, Followed by High-Performance Liquid Chromatography. 超声和涡流辅助分散液-液微萃取个人护理用品和尿液中的对羟基苯甲酸酯
IF 1.7 Pub Date : 2023-11-07 DOI: 10.4274/tjps.galenos.2022.42387
Pelin Köseoğlu Yılmaz, Ufuk Kolak

Objectives: Parabens, which are p-hydroxybenzoic acid esters, are used as preservatives in personal care products, pharmaceuticals, and food because of their antimicrobial activity. However, they are also classified as suspected endocrine disruptors and carcinogens. In the present study, we aimed to optimize an ultrasound and vortex-assisted dispersive liquid-liquid microextraction (DLLME) procedure for the simultaneous extraction of methyl, ethyl, isopropyl, propyl, isobutyl, and butyl parabens from personal care products and urine.

Materials and methods: The extraction solvent type, extraction solvent volume, disperser solvent volume, sodium chloride concentration, ultrasonication time, and vortex application time were evaluated to obtain optimum recoveries by ultrasound and vortex-assisted DLLME. Parabens were detected using a validated high performanc-liquid chromatography (HPLC) method with fluorescence detection. Method validation was performed by examining linearity, the limit of detection, limit of quantification, accuracy, and precision.

Results: The limits of detection and quantification of the HPLC method were between 0.09-0.18 μg/mL and 0.28-0.54 μg/mL, respectively. Precision was examined as the relative standard deviation, which was 0.22-1.81% and 1.12-2.03% for intra- and interday studies. Recovery percentages were higher than 96.00%. Samples of two paraben-free personal care products and synthetic urine were spiked with the analyses at 0.02 μg/mL and were successfully analyzed using the developed procedure with recovery values higher than 82.00%.

Conclusion: The proposed procedure provided quantification of selected parabens at 20 ng/mL in analyzed personal care products and urine matrices with good precision and accuracy.

目的:对羟基苯甲酸酯是一种对羟基苯甲酸酯,由于其抗菌活性,被用作个人护理产品、药品和食品的防腐剂。然而,他们也
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引用次数: 0
Prospective-Drug Utilization Evaluation Analysis in Ear, Nose, and Throat Outpatient Department: Incorporating Benchmarks and World Health Organization Indicators 耳鼻喉科门诊的前瞻性用药评估分析:纳入基准和世界卫生组织指标
IF 1.7 Pub Date : 2023-09-29 DOI: 10.4274/tjps.galenos.2022.50246
Vinodkumar Mugada, Blessy Jayamon, Bindu Krishna Kosireddy, Bhagya Sri Palisetty, Apoorva Pinisetti
Background : A drug utilization study is a tool for determining the effectiveness of drug use. Our research aims to evaluate the drug usage patterns in Ear, Nose, and Throat (ENT) outpatient settings by incorporating established benchmarks and World Health Organization (WHO) indicators. Methods : We conducted a drug utilization evaluation (DUE) study on 800 patients from the ENT outpatient department (OPD). Initially, we gathered data on the currently prescribed medications and, through careful analysis, identified discrepancies. To rectify any irrational prescribing patterns identified among physicians, we utilized continuing educational activities like 'Dear Doctor' letters and personal consultations. We applied the WHO's core indicators, specifically prescribing and patient care indicators, and established benchmarks to encourage rational prescribing. Results : The three most common diagnoses identified were pharyngitis (51.49%), allergic rhinitis (25.11%), and Acute Suppurative Otitis Media (21.17%). Montelukast, in combination with levocetirizine (13.77%) and amoxicillin paired with clavulanic acid (8.81%), were the most frequently prescribed medications. The study revealed prescribing indicators such as an excessive number of drugs per prescription (4.2), low usage of generic names (33.0%), and suboptimal reliance on the Essential Drugs List (76.7%). Furthermore, patient care indicators demonstrated room for improvement, particularly concerning consultation times (6mins
背景:药物使用研究是确定药物使用效果的一种工具。我们的研究旨在结合既定基准和世界卫生组织(WHO)指标,评估耳鼻喉科门诊的药物使用模式。方法:我们对耳鼻喉科门诊部(OPD)的 800 名患者进行了药物使用评估(DUE)研究。首先,我们收集了当前处方药物的数据,并通过仔细分析找出了差异。为了纠正在医生中发现的不合理处方模式,我们利用了 "亲爱的医生 "信件和个人咨询等持续教育活动。我们采用了世界卫生组织的核心指标,特别是处方和患者护理指标,并制定了鼓励合理处方的基准。结果:最常见的三种诊断是咽炎(51.49%)、过敏性鼻炎(25.11%)和急性化脓性中耳炎(21.17%)。孟鲁司特联合左西替利嗪(13.77%)和阿莫西林联合克拉维酸(8.81%)是最常用的处方药。研究显示了一些处方指标,如每张处方的药物数量过多(4.2)、通用名使用率低(33.0%)以及对《基本药物目录》的依赖性不足(76.7%)。此外,病人护理指标也有改进的余地,尤其是就诊时间(6 分钟
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引用次数: 0
The Inclusion of Sports & Exercise Related Module into Pharmacy Curriculum: Non-pharmacological Approach on Students’ Health Parameters 将体育锻炼相关模块纳入药学课程:非药物疗法对学生健康指标的影响
IF 1.7 Pub Date : 2023-09-20 DOI: 10.4274/tjps.galenos.2023.23428
Ahmad Rashidi Mohamed Tahir, Voon Jia Haw, Wan Sazrina Wan Zaid, M. Nizaruddin, Arimi Fitri Mat Ludin
Objectives: To promote a holistic approach to healthcare, the University of Cyberjaya (UoC) introduced a unique elective course called sport pharmacy which incorporates components of lifestyle interventions. Customers are increasingly seeking guidance on lifestyle factors that impact their health. Pharmacists with expertise in sports and exercise can meet this demand. However, there is a lack of studies about the impact of non-pharmacological approaches on health parameters among healthcare professionals and pharmacy students in Malaysia. The objectives of this study were to compare students’ health parameters based on non-pharmacological approaches and identify the factors that motivate them to maintain their health. Materials and Methods: The study comprised of 47 Year 4 pharmacy students in pre and post practical phase (September 2018 and November 2018), followed by post-resting phase (May 2019). Data collection form in the Sport Pharmacy course was used for the data collection. Results: A little less than half of the students displayed normal Body Mass Index (BMI). After the post-resting period, there was a rise in the number of students classified as obese, as well as those with high TC and FBG. Around 23% continued to control their diet and 32% maintained their physical activity levels during the post-resting study.
目标:为了推广全面的医疗保健方法,赛城大学(UoC)开设了一门名为 "运动药剂学 "的独特选修课,其中包含生活方式干预的内容。顾客越来越多地寻求有关影响其健康的生活方式因素的指导。具备运动和锻炼专业知识的药剂师可以满足这一需求。然而,在马来西亚,有关非药物疗法对医疗保健专业人员和药剂学专业学生健康参数影响的研究还很缺乏。本研究的目的是比较学生基于非药物疗法的健康参数,并确定促使他们保持健康的因素。材料和方法:该研究由 47 名四年级药剂学学生组成,分别处于实践前和实践后阶段(2018 年 9 月和 2018 年 11 月),之后是休息后阶段(2019 年 5 月)。采用运动药学课程中的数据收集表进行数据收集。结果:略少于一半的学生体质指数(BMI)正常。休息后,被归类为肥胖以及 TC 和 FBG 偏高的学生人数有所增加。在休息后的研究中,约 23% 的学生继续控制饮食,32% 的学生保持运动量。
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引用次数: 0
Timolol Maleate In Situ Ophthalmic Mucoadhesive-Thermosensitive Gel: Development and Characterization 马来酸噻吗洛尔原位眼用粘胶-热敏凝胶:开发与表征
IF 1.7 Pub Date : 2023-09-19 DOI: 10.4274/tjps.galenos.2023.50723
Sibel İLBASMIŞ TAMER, Özlem Çulcu, Eda Turan, Fahriye Figen Tirnaksiz
Objectives: The purpose of this study was to prepare a sustained delivery mucoadhesive-thermosensitive formulation containing poloxamer 338 (P338), poloxamer 188 (P188) and mucoadhesive agents such as chitosan (CHT) and carboxymethylcellulose (CMC) to increase the ophthalmic bioavailability of Timolol Maleate (TM). Materials and Methods: Gels were prepared by mixing different amounts of P338, P188 and mucoadhesive agents in cold isotonic water with a magnetic stirrer. The sol-gel gelation time of the gels was determined using the test tube inversion method. Viscosity measurements and analysis of mechanical properties of gel formulations were carried out. In vitro release using dialysis membrane and ex vivo permeation studies using fresh cow eyes were performed.
研究目的本研究的目的是制备一种持续给药的粘附热敏制剂,该制剂含有 poloxamer 338 (P338)、poloxamer 188 (P188)以及壳聚糖 (CHT) 和羧甲基纤维素 (CMC) 等粘附剂,以提高马来酸噻吗洛尔 (TM) 的眼用生物利用度。材料和方法:在磁力搅拌器的作用下,将不同量的 P338、P188 和粘合剂在冷等渗水中混合,制备凝胶。采用试管倒置法测定凝胶的溶胶-凝胶凝胶化时间。对凝胶配方进行了粘度测量和机械性能分析。使用透析膜进行了体外释放研究,并使用新鲜牛眼进行了体内外渗透研究。
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引用次数: 0
Hemagglutinin from the Root Tuber of Dioscorea preussii Pax Exhibit Antioxidative Prowess and Haemolysis Inhibition 白果薯蓣块根中的血凝素具有抗氧化能力和溶血抑制作用
IF 1.7 Pub Date : 2023-09-19 DOI: 10.4274/tjps.galenos.2023.62293
O. Odekanyin, Sunday Isaiah Akanni
Objectives: In this research, Dioscorea preussii root tuber haemagglutinin was purified and its physicochemical properties determined. The antioxidative prowess and anti-haemolytic activities of the haemagglutinin were also investigated. Material and Methods: Hemagglutinating assay was used to detect the presence of lectin in the Phosphate Buffer Saline (PBS) extract of the D. preussii root tuber. The lectin was purified using ammonium sulphate fractionation and molecular sieve chromatography. Optimum pH and temperature were determined. So also, antioxidant activity was assessed using DPPH radical scavenging, metal chelating, FRAP and lipid peroxidation inhibition assays. Red blood cells subjected to oxidative damage caused by H 2 O 2 was employed to evaluate its antihemolytic ability. Results: Starch inhibited the haemagglutinating activity of the hemagglutinin. Dioscorea preussii haemagglutinin (DPH) maintained full haemagglutinating activity from 30 ºC to 60 ºC and pH 5-13. EDTA had no effect on the haemagglutinating activity of the haemagglutinin. All the denaturing agents (Guanidine-HCl, Urea and β-Mercaptoethanol
研究目的本研究纯化了薯蓣块根血凝素,并测定了其理化性质。还研究了血凝素的抗氧化能力和抗溶血活性。材料与方法:血凝试验用于检测磷酸盐缓冲盐水(PBS)提取物中块根凝集素的存在。使用硫酸铵分馏和分子筛色谱法纯化凝集素。确定了最佳 pH 值和温度。此外,还使用 DPPH 自由基清除、金属螯合、FRAP 和脂质过氧化抑制试验对抗氧化活性进行了评估。利用 H 2 O 2 对红细胞造成的氧化损伤来评估其抗溶血能力。结果表明淀粉能抑制血凝素的血凝活性。薯蓣血凝素(DPH)在 30 ºC 至 60 ºC 和 pH 值为 5-13 的条件下保持完全的血凝活性。乙二胺四乙酸对血凝素的血凝活性没有影响。所有变性剂(胍-盐酸盐、尿素和 β-巯基乙醇)都对血凝素的血凝活性没有影响。
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引用次数: 0
A novel controlled release implant of insulin based on Poly (3- hydroxybutyrate-co-3-hydroxyvalerate) polymer prepared by extrusion process 基于挤出法制备聚(3-羟基丁酸酯-co-3-羟基戊酸酯)聚合物的新型胰岛素控释植入物
IF 1.7 Pub Date : 2023-08-28 DOI: 10.4274/tjps.galenos.2023.10663
F. Pakdel, J. Pakdel, Ali Najmeddin, Afshin Peirovi, M. H. Nicknam, F. Dorkoosh
Introduction Developing and designing an implant with a controlled release of active protein drugs has always been a challenge. In order to optimize and control the release of insulin in this project, the drug complexing mechanism was used by dextran sulfate sodium and PHBV (Poly (3-hydroxybutyrate-co-3-hydroxyvalerate)) polymer. Methods For this purpose
引言开发和设计一种能控制活性蛋白药物释放的植入物一直是一项挑战。为了优化和控制本项目中胰岛素的释放,右旋糖酐硫酸钠和PHBV(聚(3-羟基丁酸酯-co-3-羟基戊酸酯)聚合物采用了药物络合机制。为此目的的方法
{"title":"A novel controlled release implant of insulin based on Poly (3- hydroxybutyrate-co-3-hydroxyvalerate) polymer prepared by extrusion process","authors":"F. Pakdel, J. Pakdel, Ali Najmeddin, Afshin Peirovi, M. H. Nicknam, F. Dorkoosh","doi":"10.4274/tjps.galenos.2023.10663","DOIUrl":"https://doi.org/10.4274/tjps.galenos.2023.10663","url":null,"abstract":"Introduction Developing and designing an implant with a controlled release of active protein drugs has always been a challenge. In order to optimize and control the release of insulin in this project, the drug complexing mechanism was used by dextran sulfate sodium and PHBV (Poly (3-hydroxybutyrate-co-3-hydroxyvalerate)) polymer. Methods For this purpose","PeriodicalId":23378,"journal":{"name":"Turkish Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48709722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development and Validation of a Spectrofluorimetric Method for the Quantification of Capecitabine in Bulk and Tablets. 卡培他滨原料药和片剂的荧光定量方法的建立和验证。
IF 1.7 Pub Date : 2023-08-22 DOI: 10.4274/tjps.galenos.2022.46364
Swathi Naraparaju, Ambati Mukti, Durga Panikumar Anumolu, Soujanya Chaganti

Objectives: A new, simple, and affordable spectrofluorimetric method was established for quantification of capecitabine in bulk and in marketed formulations.

Materials and methods: Native fluorescence of capecitabine in 0.1% (w/v) cetrimide was measured at 386 nm after excitation at 313 nm.

Results: A linear relationship between fluorescence intensity and capecitabine concentration was noticed in 0.2-1.0 μg/mL range. The method was supported by checking several validation parameters as stated using International Conference on Harmonization (ICH) guidelines. The limit of detection (LOD) and quantification (LOQ) values (0.032 and 0.096 μg/mL, respectively) and results of validation parameters demonstrated that the method procedure were sensitive, accurate, precise, and reproducible (% relative standard deviation <2.0). The percentage assay in commercial formulation was found to be 99.2, which agrees with ICH guidelines.

Conclusion: Due to the above findings, developed method can be successfully adopted for routine analysis of capecitabine in pharmaceutical dosage forms.

目的:建立一种新的、简单的、价格合理的卡培他滨定量分析方法。材料和方法:在313 nm激发后,在386 nm处测定0.1% (w/v)西特里胺中卡培他滨的天然荧光。结果:在0.2 ~ 1.0 μg/mL范围内,荧光强度与卡培他滨浓度呈线性关系。该方法通过检查国际协调会议(ICH)指南中规定的几个验证参数来支持。检出限(LOD)和定量限(LOQ)分别为0.032和0.096 μg/mL,验证参数结果表明,该方法灵敏、准确、精密度高,重复性好(%相对标准偏差)。结论:该方法可用于卡培他滨制剂的常规分析。
{"title":"Development and Validation of a Spectrofluorimetric Method for the Quantification of Capecitabine in Bulk and Tablets.","authors":"Swathi Naraparaju,&nbsp;Ambati Mukti,&nbsp;Durga Panikumar Anumolu,&nbsp;Soujanya Chaganti","doi":"10.4274/tjps.galenos.2022.46364","DOIUrl":"https://doi.org/10.4274/tjps.galenos.2022.46364","url":null,"abstract":"<p><strong>Objectives: </strong>A new, simple, and affordable spectrofluorimetric method was established for quantification of capecitabine in bulk and in marketed formulations.</p><p><strong>Materials and methods: </strong>Native fluorescence of capecitabine in 0.1% (<i>w/v</i>) cetrimide was measured at 386 nm after excitation at 313 nm.</p><p><strong>Results: </strong>A linear relationship between fluorescence intensity and capecitabine concentration was noticed in 0.2-1.0 μg/mL range. The method was supported by checking several validation parameters as stated using International Conference on Harmonization (ICH) guidelines. The limit of detection (LOD) and quantification (LOQ) values (0.032 and 0.096 μg/mL, respectively) and results of validation parameters demonstrated that the method procedure were sensitive, accurate, precise, and reproducible (% relative standard deviation <2.0). The percentage assay in commercial formulation was found to be 99.2, which agrees with ICH guidelines.</p><p><strong>Conclusion: </strong>Due to the above findings, developed method can be successfully adopted for routine analysis of capecitabine in pharmaceutical dosage forms.</p>","PeriodicalId":23378,"journal":{"name":"Turkish Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10445222/pdf/TJPS-20-234.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10121671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Evaluation of Marketed Rosemary Essential Oils (Rosmarinus officinalis L.) in Terms of European Pharmacopoeia 10.0 Criteria. 根据欧洲药典10.0标准对市售迷迭香精油的评价。
IF 1.7 Pub Date : 2023-08-22 DOI: 10.4274/tjps.galenos.2022.78010
Timur Hakan Barak, Elif Bölükbaş, Hilal Bardakcı

Objectives: Various pure rosemary essential oil containing commercial products are in demand for their health-promoting and cosmetic claims in Türkiye. Although they are natural and harmless, they should be in compliance with European Pharmacopoeia (EP) criteria. Therefore, in this study, 15 rosemary oil samples sold in pharmacies, herbal shops, and online platforms in Türkiye were investigated in terms of "Rosemary Oil" EP 10.0. monograph criteria. In the current study, we aimed to evaluate the current quality status of rosemary essential oils in the Turkish market.

Materials and methods: Appearance, fatty oils and resinified essential oils, relative density, refractive index, optical rotation, and acid value tests were performed according to EP 10.0 and compared with the given standards. In addition, thin layer chromatography (TLC) and gas chromatography-mass spectrometry (GC-MS) analysis were conducted on all samples for advanced understanding of their phytochemical profile and harmony with EP standards.

Results: Fifteen pure rosemary oil-containing products from the Turkish market were evaluated. All of the samples were licensed as cosmetic products in Türkiye via the Ministry of Health. 83.1 to 96.9% of the ingredients of all samples were determined via GC-MS analysis. Results demonstrated that none of the samples from the Turkish rosemary essential oil market fully complied with the EP rosemary oil monograph standards.

Conclusion: Considering our data, it was revealed that enhanced regulations and auditing mechanisms are needed to improve the quality of products. When the difference between the sources of purchase is assessed, pharmacies are still better locations to obtain such products.

目的:各种纯迷迭香精油含有商业产品的需求是他们的健康促进和化妆品声称在 rkiye。虽然它们是天然无害的,但它们应符合欧洲药典(EP)标准。因此,本研究以“迷迭香油”EP 10.0为标准,对我国药店、草药店、网络平台销售的15份迷迭香油样品进行了调查。论文的标准。在本研究中,我们旨在评估土耳其市场上迷迭香精油的质量现状。材料和方法:按照ep10.0进行外观、脂肪油和树脂化精油、相对密度、折射率、旋光度和酸值测试,并与给定标准进行比较。此外,对所有样品进行薄层色谱(TLC)和气相色谱-质谱(GC-MS)分析,以进一步了解其植物化学特征,并与EP标准保持一致。结果:对土耳其市场15种含迷迭香油的纯产品进行了评价。所有样品均经卫生部批准为日本化妆品,所有样品中83.1 ~ 96.9%的成分通过GC-MS分析。结果表明,土耳其迷迭香精油市场样品均不完全符合欧盟迷迭香精油专著标准。结论:结合我们的数据,需要加强监管和审计机制来提高产品质量。当评估采购来源之间的差异时,药店仍然是获得此类产品的较好地点。
{"title":"Evaluation of Marketed Rosemary Essential Oils (<i>Rosmarinus officinalis</i> L.) in Terms of European Pharmacopoeia 10.0 Criteria.","authors":"Timur Hakan Barak,&nbsp;Elif Bölükbaş,&nbsp;Hilal Bardakcı","doi":"10.4274/tjps.galenos.2022.78010","DOIUrl":"https://doi.org/10.4274/tjps.galenos.2022.78010","url":null,"abstract":"<p><strong>Objectives: </strong>Various pure rosemary essential oil containing commercial products are in demand for their health-promoting and cosmetic claims in Türkiye. Although they are natural and harmless, they should be in compliance with European Pharmacopoeia (EP) criteria. Therefore, in this study, 15 rosemary oil samples sold in pharmacies, herbal shops, and online platforms in Türkiye were investigated in terms of \"Rosemary Oil\" EP 10.0. monograph criteria. In the current study, we aimed to evaluate the current quality status of rosemary essential oils in the Turkish market.</p><p><strong>Materials and methods: </strong>Appearance, fatty oils and resinified essential oils, relative density, refractive index, optical rotation, and acid value tests were performed according to EP 10.0 and compared with the given standards. In addition, thin layer chromatography (TLC) and gas chromatography-mass spectrometry (GC-MS) analysis were conducted on all samples for advanced understanding of their phytochemical profile and harmony with EP standards.</p><p><strong>Results: </strong>Fifteen pure rosemary oil-containing products from the Turkish market were evaluated. All of the samples were licensed as cosmetic products in Türkiye <i>via</i> the Ministry of Health. 83.1 to 96.9% of the ingredients of all samples were determined <i>via</i> GC-MS analysis. Results demonstrated that none of the samples from the Turkish rosemary essential oil market fully complied with the EP rosemary oil monograph standards.</p><p><strong>Conclusion: </strong>Considering our data, it was revealed that enhanced regulations and auditing mechanisms are needed to improve the quality of products. When the difference between the sources of purchase is assessed, pharmacies are still better locations to obtain such products.</p>","PeriodicalId":23378,"journal":{"name":"Turkish Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10445223/pdf/TJPS-20-253.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10421182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Role of Chitosan-Loaded Solanine Glycoalkaloid from Solanum scabrum Mill. Leaf Extract as Anti-Inflammatory and In Vitro Anticancer Agents. 壳聚糖负载龙葵碱糖生物碱的作用。叶提取物的抗炎和体外抗癌作用。
IF 1.7 Pub Date : 2023-08-22 DOI: 10.4274/tjps.galenos.2022.03837
Cletus Anes Ukwubile, Emmanuel Oise Ikpefan, Ademola Clement Famurewa

Objectives: Solanum scabrum Mill. commonly "African nightshade" or "huckleberry" is a plant, whose leaves are used by tribes in Nigeria and Cameroon for making the popular "Kombi" and "Njama Njama" soups, respectively. This study aimed to evaluate the anti-inflammatory and anticancer activities of the leaf crude methanol extract from S. scabrum.

Materials and methods: Fractions of the plant were tested for anti-inflammatory potential and in vitro anticancer activity on MCF-7 and HMVII cell lines by carrageenan-induced oedema in mice, and cytotoxicity assays such as 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide, transwell migration and invasion assays, and apoptosis study by flow cytometry, respectively.

Results: Bioguided isolation yielded a white crystalline compound 3-nitro dibenzofuran (C12H7NO3, m/z; 213.19 g/mol, m.p.; 181.49 °C). 1H-NMR showed seven signals at δ (ppm) 2.8-4.3 consisting of two doublets and five singlets, while 13C-NMR revealed twelve carbons, which are majorly methyl carbons at δ (ppm) between 120 and 195. All tested samples demonstrated dose-dependent anti-inflammatory activity in carrageenan-induced mice. The isolated compound, i.e. solanine, and chitosan-loaded drugs showed significant inhibitory activity on the cell lines with inhibitory concentration 50 (IC50) values of 8.52, 0.82, and 22.1 μg/mL, respectively on MCF-7 cell line and 4.54, 0.08, and 12.1 μg/mL, respectively, on HMVII cell line, while doxorubicin (adriamycin) positive control, had IC50 values of 0.02 and 0.06 μg/mL, respectively, on MCF-7 and HMVII cancer cells. Selectivity index of solanine was the lowest in the study, hence, it lacks the ability to differentiate between cancerous and normal cell Vero E6 cell lines. Chitosan-loaded drugs quicken early apoptosis and sustained late apoptosis in cells with much improved selective indices.

Conclusion: The results obtained from this study further affirmed the use of chitosan nanoparticles as carriers for anticancer drugs.

目的:药用龙葵。通常“非洲龙葵”或“越橘”是一种植物,其叶子被尼日利亚和喀麦隆的部落分别用来制作流行的“Kombi”和“Njama Njama”汤。本研究旨在评价黄芩叶粗甲醇提取物的抗炎和抗癌活性。材料与方法:采用角叉菜胶诱导小鼠浮肿的方法,检测植物提取物对MCF-7和HMVII细胞系的抗炎活性和体外抗癌活性,并采用流式细胞术分别进行3-(4,5-二甲基噻唑-2-基)-2,5-二苯基- 2h -溴化四氮唑、跨井迁移和侵袭实验以及细胞凋亡研究等细胞毒性试验。结果:生物引导分离得到白色结晶化合物3-硝基二苯并呋喃(C12H7NO3, m/z;213.19 g/mol, m.p;181.49°C)。1H-NMR在δ (ppm) 2.8 ~ 4.3处显示7个碳信号,包括2个双线和5个单线;13C-NMR在δ (ppm) 120 ~ 195处显示12个碳信号,主要是甲基碳。所有测试样品在卡拉胶诱导的小鼠中显示出剂量依赖性的抗炎活性。分离得到的茄碱和壳聚糖负载药物对MCF-7和HMVII细胞的抑制浓度分别为8.52、0.82和22.1 μg/mL,抑制浓度分别为4.54、0.08和12.1 μg/mL,而阳性对照阿霉素对MCF-7和HMVII细胞的抑制浓度分别为0.02和0.06 μg/mL。在本研究中,龙葵碱的选择性指数最低,因此缺乏对Vero E6细胞系癌细胞和正常细胞的区分能力。壳聚糖负载药物加速细胞早期凋亡和持续细胞晚期凋亡,并显著改善细胞的选择性指标。结论:本研究结果进一步肯定了壳聚糖纳米颗粒作为抗癌药物载体的应用前景。
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引用次数: 2
期刊
Turkish Journal of Pharmaceutical Sciences
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