Pub Date : 2020-07-30DOI: 10.46243/jst.2020.v5.i4.pp238-247
: A basic wheelchair is a gadget for people influenced by moderate, extreme physical incapacities and interminable disease. It is also meant for the elderly people. Many people with disabilities cannot manage the energized wheelchair operating joystick, sound, furthermore, hand developments as it is harder for the individual to do such specific tasks also it is programming focused. This strategy comprises of equipment which reduces the person's work utilizing the image processing method. This model comprised of a camera that tracks the eyeball movement and hence the position of the pupil by the image processing technique. And thereby the wheelchair is constrained by a user’s eye gesture in an indoor space. When the development has been initiated and it is given to the Raspberry pi for processing. The procedure relies on the feed coding and an output is given into the driver circuit. Likewise, the hindrance location sensors will be associated as an Emergency Brake that gives necessary conditions for the conventional activity of the wheelchair framework. Every one of the four wheels are associated with a driving circuit that moves the wheelchair
{"title":"Eyeball Controlled Wheelchair","authors":"","doi":"10.46243/jst.2020.v5.i4.pp238-247","DOIUrl":"https://doi.org/10.46243/jst.2020.v5.i4.pp238-247","url":null,"abstract":": A basic wheelchair is a gadget for people influenced by moderate, extreme physical incapacities and\u0000interminable disease. It is also meant for the elderly people. Many people with disabilities cannot manage the\u0000energized wheelchair operating joystick, sound, furthermore, hand developments as it is harder for the individual to\u0000do such specific tasks also it is programming focused. This strategy comprises of equipment which reduces the\u0000person's work utilizing the image processing method. This model comprised of a camera that tracks the eyeball\u0000movement and hence the position of the pupil by the image processing technique. And thereby the wheelchair is\u0000constrained by a user’s eye gesture in an indoor space. When the development has been initiated and it is given to\u0000the Raspberry pi for processing. The procedure relies on the feed coding and an output is given into the driver\u0000circuit. Likewise, the hindrance location sensors will be associated as an Emergency Brake that gives necessary\u0000conditions for the conventional activity of the wheelchair framework. Every one of the four wheels are associated\u0000with a driving circuit that moves the wheelchair","PeriodicalId":23534,"journal":{"name":"Volume 5, Issue 4","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81636845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-30DOI: 10.46243/jst.2020.v5.i4.pp87-105
Concerns for the future of our environment, with regards to climate change, scarcity of resources, population growth, and globalization are growing, we need alternative solutions as to how can we reduce the negative impact of all the above on the planet while catering the needs of the mass. Only recently has there been debates if or not vernacular and traditional aspects of architecture can be the key to the required change. Courtyards and open spaces are one of the attributes of vernacular architecture that needs to be discussed in the above context. The importance of these spaces had already been proven for different climatic conditions. However, there is a need to justify this kind of open space typology in the lights of contemporary architecture of a metropolitan city like Delhi which is having a diverse urban fabric, a high rate of influx, and also cultural diversification. Given that the most common and relatable architectural typology is the dwelling, and it is subjected to a rapid transformation concerning its built as well as use. The following case takes into consideration the residential open spaces of Delhi through a comparative study of residential courtyard spaces of Delhi hence, the paper tries to form a conception of open spaces in the residential typology of Delhi post-independence and hence, tries to study the dwellings of the same time dating from the 1950s till date it also provides the reader an insight to the reasoning of flattening of built forms that have emerged in today’s era, despite the heterogeneity of people and what are the possible solutions to this through the understanding of courtyard spaces and use its functional benefits like comfort and a sense of belongingness.
{"title":"Conception of open spaces- A Case of Delhi Courtyard Houses","authors":"","doi":"10.46243/jst.2020.v5.i4.pp87-105","DOIUrl":"https://doi.org/10.46243/jst.2020.v5.i4.pp87-105","url":null,"abstract":"Concerns for the future of our environment, with regards to climate change, scarcity of resources,\u0000population growth, and globalization are growing, we need alternative solutions as to how can we reduce the\u0000negative impact of all the above on the planet while catering the needs of the mass. Only recently has there been\u0000debates if or not vernacular and traditional aspects of architecture can be the key to the required change.\u0000Courtyards and open spaces are one of the attributes of vernacular architecture that needs to be discussed in the\u0000above context. The importance of these spaces had already been proven for different climatic conditions. However,\u0000there is a need to justify this kind of open space typology in the lights of contemporary architecture of a\u0000metropolitan city like Delhi which is having a diverse urban fabric, a high rate of influx, and also cultural\u0000diversification. Given that the most common and relatable architectural typology is the dwelling, and it is subjected\u0000to a rapid transformation concerning its built as well as use. The following case takes into consideration the\u0000residential open spaces of Delhi through a comparative study of residential courtyard spaces of Delhi hence, the\u0000paper tries to form a conception of open spaces in the residential typology of Delhi post-independence and hence,\u0000tries to study the dwellings of the same time dating from the 1950s till date it also provides the reader an insight to\u0000the reasoning of flattening of built forms that have emerged in today’s era, despite the heterogeneity of people and\u0000what are the possible solutions to this through the understanding of courtyard spaces and use its functional benefits\u0000like comfort and a sense of belongingness.","PeriodicalId":23534,"journal":{"name":"Volume 5, Issue 4","volume":"04 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88780860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-30DOI: 10.46243/jst.2020.v5.i4.pp288-307
: Isatin is a naturally occurring substance identified in humans, animals, plants and coal tar. Isatin derivatives are reported to possess a wide range of activites. This review is in continuation of “Part-1 (1877-2002)” review published by our team. This review encompasses the most signigicant reports published during 2002 to 2020 on the biological & pharmacological activites of isatin and its derivatives. The review includes the various synthetic reactions of isatin and activites reported. The pharmacological and biological activites reported were antimicrobial, antineoplastic & related activities; analgesic, anti-inflammatory, anticonvulsant, antioxidant, activity against veterinary pathogen, effects on cardiac & vascular smooth muscles; transthyretin fibrillogenesis inhibitor and antiglycation activity of isatin compounds.
{"title":"Review of Chemical, Pharmacological, Biological Activities of Isatin\u0000and Its Derivatives – Part-2 (2002 To 2020)","authors":"","doi":"10.46243/jst.2020.v5.i4.pp288-307","DOIUrl":"https://doi.org/10.46243/jst.2020.v5.i4.pp288-307","url":null,"abstract":": Isatin is a naturally occurring substance identified in humans, animals, plants and coal tar. Isatin\u0000derivatives are reported to possess a wide range of activites. This review is in continuation of “Part-1 (1877-2002)”\u0000review published by our team. This review encompasses the most signigicant reports published during 2002 to 2020\u0000on the biological & pharmacological activites of isatin and its derivatives. The review includes the various\u0000synthetic reactions of isatin and activites reported. The pharmacological and biological activites reported were\u0000antimicrobial, antineoplastic & related activities; analgesic, anti-inflammatory, anticonvulsant, antioxidant, activity\u0000against veterinary pathogen, effects on cardiac & vascular smooth muscles; transthyretin fibrillogenesis inhibitor\u0000and antiglycation activity of isatin compounds.","PeriodicalId":23534,"journal":{"name":"Volume 5, Issue 4","volume":"105 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88120635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-30DOI: 10.46243/jst.2020.v5.i4.pp173-187
Lopinavir is the anti HIV drug which is used to treat the HIV-1 infection. In this study we used the single lopinavir drug to formulate the polymeric micelle. This study was done with the two main objectives as Objective:first to enhance the solubility and bioavailability of the BCS class IV drug and second to avoid the combination of lopinavir rand ritonavir and use single lopinavir to preparation of polymeric micelle also to avoid the disadvantages related to the oral administration. Method:The different pluronic (F188 &F127) and co-solvent (Tween80) were chosen & the micelles were prepared by using different Drug: polymer ratio with or without cosolvent and drug Lopinavir. Formulations were been characterized by critical micelle concentration(CMC) value, micellesize,DSC, XRD, loading efficiency, % drug loading and stability.Result:Mixed micelle (hydrophobic &hydrophilic) obtained from optimized batch shows the highest entrapment of 29%with the pluronic F68 with the use of co-solvent and the vesicle size of 0.156µm the DSC, FTIR, XRD study was also done for lopinavir and optimized formulation .Conclusion: The pluronic F68 with the co-solvent showed fairly high entrapment efficiency, loading capacity than the mixed Pluronic in combination
{"title":"Formulation, Development and Evaluation of Lopinavir Loaded\u0000Polymeric Micelles","authors":"","doi":"10.46243/jst.2020.v5.i4.pp173-187","DOIUrl":"https://doi.org/10.46243/jst.2020.v5.i4.pp173-187","url":null,"abstract":"Lopinavir is the anti HIV drug which is used to treat the HIV-1 infection. In this study we used the single\u0000lopinavir drug to formulate the polymeric micelle. This study was done with the two main objectives as\u0000Objective:first to enhance the solubility and bioavailability of the BCS class IV drug and second to avoid the\u0000combination of lopinavir rand ritonavir and use single lopinavir to preparation of polymeric micelle also to avoid\u0000the disadvantages related to the oral administration. Method:The different pluronic (F188 &F127) and co-solvent\u0000(Tween80) were chosen & the micelles were prepared by using different Drug: polymer ratio with or without cosolvent and drug Lopinavir. Formulations were been characterized by critical micelle concentration(CMC) value,\u0000micellesize,DSC, XRD, loading efficiency, % drug loading and stability.Result:Mixed micelle (hydrophobic\u0000&hydrophilic) obtained from optimized batch shows the highest entrapment of 29%with the pluronic F68 with the\u0000use of co-solvent and the vesicle size of 0.156µm the DSC, FTIR, XRD study was also done for lopinavir and\u0000optimized formulation .Conclusion: The pluronic F68 with the co-solvent showed fairly high entrapment efficiency,\u0000loading capacity than the mixed Pluronic in combination","PeriodicalId":23534,"journal":{"name":"Volume 5, Issue 4","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79868959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-30DOI: 10.46243/jst.2020.v5.i4.pp248-260
:In the past few years of research done in the field of myoelectric control, many researchers have proposed several models imploying a combination of different features and classifiers to increase the movement classes, but all that work fails to explain if there is any correlation between multi-class classification and its accuracy. This paper focuses on finding the factors that decide the limit of movement classes that machine learning algorithms can accurately differentiate and to evaluate the performance of pattern classification techniques using the sEMG signal when the number of movement classes is increased while keeping the simplicity of the system. The results were obtained for eight channels sEMG signal using 7 independent time-domain features and four feature set combinations over 4 classifiers (Support Vector Machine(SVM), K-Nearest Neighbour(K-NN), Decision Tree(DT), and Naïve Bayes(NB)). Then the number of classes was increased in the manner of 5, 7, 10, 12, and 15 classes to determine the highest number of movement classes that the sEMG system with above-described features can classify efficiently. And the effect of increasing the number of movement classes on system accuracy was observed. The highest accuracies for all five class progression were obtained for SVM with the MFL feature, and for DT using MAV, it was successfully observed that the NB classifier had minimum performance depletion for the features used in this work
{"title":"Performance Evaluation of EMG Pattern Recognition Techniques\u0000While Increasing The Number of Movement Classes","authors":"","doi":"10.46243/jst.2020.v5.i4.pp248-260","DOIUrl":"https://doi.org/10.46243/jst.2020.v5.i4.pp248-260","url":null,"abstract":":In the past few years of research done in the field of myoelectric control, many researchers have proposed\u0000several models imploying a combination of different features and classifiers to increase the movement classes, but\u0000all that work fails to explain if there is any correlation between multi-class classification and its accuracy. This\u0000paper focuses on finding the factors that decide the limit of movement classes that machine learning algorithms can\u0000accurately differentiate and to evaluate the performance of pattern classification techniques using the sEMG signal\u0000when the number of movement classes is increased while keeping the simplicity of the system. The results were\u0000obtained for eight channels sEMG signal using 7 independent time-domain features and four feature set\u0000combinations over 4 classifiers (Support Vector Machine(SVM), K-Nearest Neighbour(K-NN), Decision Tree(DT),\u0000and Naïve Bayes(NB)). Then the number of classes was increased in the manner of 5, 7, 10, 12, and 15 classes to\u0000determine the highest number of movement classes that the sEMG system with above-described features can classify\u0000efficiently. And the effect of increasing the number of movement classes on system accuracy was observed. The\u0000highest accuracies for all five class progression were obtained for SVM with the MFL feature, and for DT using\u0000MAV, it was successfully observed that the NB classifier had minimum performance depletion for the features used\u0000in this work","PeriodicalId":23534,"journal":{"name":"Volume 5, Issue 4","volume":"73 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86257006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-30DOI: 10.46243/jst.2020.v5.i4.pp348-360
:Today’s technological advancements facilitated the researcher in collecting and organizing various forms of healthcare data. Data is an integral part of health care analytics. Drug discovery for clinical data analytics forms an important breakthrough work in terms of computational approaches in health care systems. On the other hand, healthcare analysis provides better value for money. The health care data management is very challenging as 80% of the data is unstructured as it includes handwritten documents, images; computer-generated clinical reports such as MRI, ECG, city scan, etc. The paper aims at providing a summary of work carried out by scientists and researchers who worked in health care domains. More precisely the work focuses on clinical data analysis for the period 2013 to 2019. The organization of the work carried out is specifically with concerned to data sets, Techniques, and Methods used, Tools adopted, Key Findings in clinical data analysis. The overall objective is to identify the current challenges, trends, and gaps in clinical data analysis. The pathway of the work is focused on carrying out on the bibliometric survey and summarization of the key findings in a novel way.
{"title":"Challenges and Trends in Clinical Data Analytics","authors":"","doi":"10.46243/jst.2020.v5.i4.pp348-360","DOIUrl":"https://doi.org/10.46243/jst.2020.v5.i4.pp348-360","url":null,"abstract":":Today’s technological advancements facilitated the researcher in collecting and organizing various forms\u0000of healthcare data. Data is an integral part of health care analytics. Drug discovery for clinical data analytics forms\u0000an important breakthrough work in terms of computational approaches in health care systems. On the other hand,\u0000healthcare analysis provides better value for money. The health care data management is very challenging as 80%\u0000of the data is unstructured as it includes handwritten documents, images; computer-generated clinical reports such\u0000as MRI, ECG, city scan, etc. The paper aims at providing a summary of work carried out by scientists and\u0000researchers who worked in health care domains. More precisely the work focuses on clinical data analysis for the\u0000period 2013 to 2019. The organization of the work carried out is specifically with concerned to data sets,\u0000Techniques, and Methods used, Tools adopted, Key Findings in clinical data analysis. The overall objective is to\u0000identify the current challenges, trends, and gaps in clinical data analysis. The pathway of the work is focused on\u0000carrying out on the bibliometric survey and summarization of the key findings in a novel way.","PeriodicalId":23534,"journal":{"name":"Volume 5, Issue 4","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88123657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-30DOI: 10.46243/jst.2020.v5.i4.pp261-267
S. Chaudhari, Sneha U. Gaikwad
Vesicular drug delivery system has various advantages thereby improving therapeutic efficacy and by sustaining and controlling action of drugs. Liposomes, sphingosomes, ethosomes, cubosomes, pharmacasomes, niosomes, transferosomes are the newly developed vesicular drug delivery system. This review article mainly deals with the sphingosomal drug delivery system. Sphingosomes are vesicular drug delivery systems in which an aqueous volume is enclosed with sphingolipid bilayer membranes. Sphingosomes has an enhanced area of interest because of their applicability in improving the in vivo delivery of various chemotherapeutic agents, biological macromolecules and diagnostics. Sphingosome has major advantages over other vesicular drug delivery systems like high stability, more in vivo circulation time, high tumor loading efficacy in case of cancer therapy as compared to liposomes, niosomes etc. Sphingosomes are clinically used vesicular delivery system for chemotherapeutic agent, biological macromolecule and diagnostics. This review concluded that sphingosome represents a promising vesicular drug delivery system for a range of possible therapeutic applications.
{"title":"Sphingosomes: A Novel Lipoidal Vesicular Drug Delivery System","authors":"S. Chaudhari, Sneha U. Gaikwad","doi":"10.46243/jst.2020.v5.i4.pp261-267","DOIUrl":"https://doi.org/10.46243/jst.2020.v5.i4.pp261-267","url":null,"abstract":"Vesicular drug delivery system has various advantages thereby improving therapeutic efficacy and by\u0000sustaining and controlling action of drugs. Liposomes, sphingosomes, ethosomes, cubosomes, pharmacasomes,\u0000niosomes, transferosomes are the newly developed vesicular drug delivery system. This review article mainly deals\u0000with the sphingosomal drug delivery system. Sphingosomes are vesicular drug delivery systems in which an aqueous\u0000volume is enclosed with sphingolipid bilayer membranes. Sphingosomes has an enhanced area of interest because of\u0000their applicability in improving the in vivo delivery of various chemotherapeutic agents, biological macromolecules\u0000and diagnostics. Sphingosome has major advantages over other vesicular drug delivery systems like high stability,\u0000more in vivo circulation time, high tumor loading efficacy in case of cancer therapy as compared to liposomes,\u0000niosomes etc. Sphingosomes are clinically used vesicular delivery system for chemotherapeutic agent, biological\u0000macromolecule and diagnostics. This review concluded that sphingosome represents a promising vesicular drug\u0000delivery system for a range of possible therapeutic applications.","PeriodicalId":23534,"journal":{"name":"Volume 5, Issue 4","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85285872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-30DOI: 10.46243/jst.2020.v5.i4.pp188-198
: The whole ship is dependent on the propeller shaft for its movement, the vibrations produced from the shaft destabilizes the whole ship and may lead to accidents. With this objective in mind, in this paper, we describe a methodology to detect and locate the crack present in the intermediate simply supported shaft using experimental modal analysis. In the present work, 304 stainless steel material shaft is taken as the specimen as it is one of the most versatile and widely used steels in the world for making different shafts used in any machinery equipment like ships propeller shaft, engine shafts, motor shafts. Initially, analytical analysis is done on the simply supported shaft then numerical modal analysis using ANSYS 2019 R3 software. Results obtained from the numerical modal analysis are compared with the experimental modal analysis which is done using FFT analyzer. Finally, the first three natural frequencies are used as a tool to detect damage detection and location in the propeller intermediate shaft
{"title":"Frequency Based Damage Detection and Localization of Propeller\u0000Shaft of a Ship Using Experimental Modal Analysis","authors":"","doi":"10.46243/jst.2020.v5.i4.pp188-198","DOIUrl":"https://doi.org/10.46243/jst.2020.v5.i4.pp188-198","url":null,"abstract":": The whole ship is dependent on the propeller shaft for its movement, the vibrations produced from the\u0000shaft destabilizes the whole ship and may lead to accidents. With this objective in mind, in this paper, we describe a\u0000methodology to detect and locate the crack present in the intermediate simply supported shaft using experimental\u0000modal analysis. In the present work, 304 stainless steel material shaft is taken as the specimen as it is one of the\u0000most versatile and widely used steels in the world for making different shafts used in any machinery equipment like\u0000ships propeller shaft, engine shafts, motor shafts. Initially, analytical analysis is done on the simply supported shaft\u0000then numerical modal analysis using ANSYS 2019 R3 software. Results obtained from the numerical modal analysis\u0000are compared with the experimental modal analysis which is done using FFT analyzer. Finally, the first three\u0000natural frequencies are used as a tool to detect damage detection and location in the propeller intermediate shaft","PeriodicalId":23534,"journal":{"name":"Volume 5, Issue 4","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75814920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-30DOI: 10.46243/jst.2020.v5.i4.pp149-165
:Tranylcypromine is a drug used as antidepressant,anxiolytic, nonselective MAO A/B inhibitor. This drug is used to treat depression.The research was conducted to develop a polymeric micelle using a block copolymer, Pluronic F-68 and Gelucire 50/13 to improve the permeability of Tranylcypromine (TCP). A direct dissolution method was used to prepare polymeric micelles. The prepared micelles were characterised for particle size, % EE, zeta potential, in-vitro release. These micelles solution was used to prepare in situ gel by cold method in order to achieve controlled release. Central composite design was used for optimization of both polymeric micelles and insitu nasal gel.The main objective of this research work is to develop formulation acting centrally without undergoing first pass metabolism i.ie. directly nasal to brain delivery route.
{"title":"Formulation and Characterization of Tranylcypromine loaded\u0000Polymeric Micellar In-Situ Nasal Gel for treatment of Depression","authors":"","doi":"10.46243/jst.2020.v5.i4.pp149-165","DOIUrl":"https://doi.org/10.46243/jst.2020.v5.i4.pp149-165","url":null,"abstract":":Tranylcypromine is a drug used as antidepressant,anxiolytic, nonselective MAO A/B inhibitor. This drug\u0000is used to treat depression.The research was conducted to develop a polymeric micelle using a block copolymer,\u0000Pluronic F-68 and Gelucire 50/13 to improve the permeability of Tranylcypromine (TCP). A direct dissolution\u0000method was used to prepare polymeric micelles. The prepared micelles were characterised for particle size, % EE,\u0000zeta potential, in-vitro release. These micelles solution was used to prepare in situ gel by cold method in order to\u0000achieve controlled release. Central composite design was used for optimization of both polymeric micelles and insitu nasal gel.The main objective of this research work is to develop formulation acting centrally without\u0000undergoing first pass metabolism i.ie. directly nasal to brain delivery route.","PeriodicalId":23534,"journal":{"name":"Volume 5, Issue 4","volume":"76 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79264882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-30DOI: 10.46243/jst.2020.v5.i4.pp143-148
Up to yet, there are so many industries are working on manual process. But due to an increase in technology and automation, most of the industries are now becomes worker less i.e. fully automated. There is the requirement of the laborers which makes the industries full of errors and decreases work rate to improve it and reduce errors automation are used. Most of which is performed by pneumatic actuators with electrical and automation control. there are lots of difference between a traditional factory and fully automated industry 4.0 based factory In the current industry environment, providing high-end quality service or product with the least cost is the key to success and industrial factories are trying to achieve as much performance as possible to increase their profit as well as their reputation in current industries there is the utilization of data, finding errors in the system, analysis of system performance are done very efficiently but there is lots of contrast between the traditional industry and industry 4.0 based industry is that in the industry not only data analysis can be done but also in addition to condition monitoring and fault diagnosis, components and systems able to get self-based awareness, this will provide management system with insights for the status of the factory. Hence it will provide the best performance with better management and controlling processes with better time management. This paper describes the automation process of dispensing and filling the bottles of different sizes using Industrial IoT. This process can be used for industrial purposes.
{"title":"Review on Smart Bottle Dispenser And Filling Plant Using\u0000Industrial IoT","authors":"","doi":"10.46243/jst.2020.v5.i4.pp143-148","DOIUrl":"https://doi.org/10.46243/jst.2020.v5.i4.pp143-148","url":null,"abstract":"Up to yet, there are so many industries are working on manual process. But due to an increase in\u0000technology and automation, most of the industries are now becomes worker less i.e. fully automated. There is the\u0000requirement of the laborers which makes the industries full of errors and decreases work rate to improve it and\u0000reduce errors automation are used. Most of which is performed by pneumatic actuators with electrical and\u0000automation control. there are lots of difference between a traditional factory and fully automated industry 4.0 based\u0000factory In the current industry environment, providing high-end quality service or product with the least cost is the\u0000key to success and industrial factories are trying to achieve as much performance as possible to increase their profit\u0000as well as their reputation in current industries there is the utilization of data, finding errors in the system, analysis\u0000of system performance are done very efficiently but there is lots of contrast between the traditional industry and\u0000industry 4.0 based industry is that in the industry not only data analysis can be done but also in addition to\u0000condition monitoring and fault diagnosis, components and systems able to get self-based awareness, this will\u0000provide management system with insights for the status of the factory. Hence it will provide the best performance\u0000with better management and controlling processes with better time management.\u0000This paper describes the automation process of dispensing and filling the bottles of different sizes using Industrial\u0000IoT. This process can be used for industrial purposes.","PeriodicalId":23534,"journal":{"name":"Volume 5, Issue 4","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87190525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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