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Volume 5 - 2020, Issue 9 - September最新文献

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Influence of hormonal stimulation and intermittent cold exposure on the mechanisms of formation of polycystic ovarian syndrome 激素刺激和间歇性冷暴露对多囊卵巢综合征形成机制的影响
Pub Date : 2022-07-01 DOI: 10.26565/2617-409x-2022-9-05
I. Kuzmina
Introduction. Polycystic ovary syndrome (PCOS) is one of the most pressing problems in gynecological endocrinology. The aim of the study was to elucidate the morphological changes in the ovaries of rats under various types of hormonal exposure in experimental modeling of PCOS. Materials and methods. To study three working experimental models were developed, associated with the introduction of various hormonal drugs into the body of an animal. Model I-st consisted of subcutaneous administration of an estrogen-containing drug at a dose of 3 mg for 25 days. Model II-d involved the development of PCOS by daily subcutaneous administration of 3 mg of dehydroandrostenediol sulfate. The III model - the formation of PCOS in 5 immature rats using dopamine phytoanalogues at a dose of 3 mg subcutaneously for 25 days. The animals were divided into 3 groups: group 1 - rats that were induced with experimental PCOS and kept in a vivarium at a temperature of +23°C (n=8), group 2 - animals that, against the background of experimental PCOS, were exposed to cold exposure (CE) for 4 hours in a chamber with a constant light regime and a temperature of + 4 °C for 25 days (n = 8); group 3 - intact control (n = 8) - healthy rats without PCOS, which were kept in a vivarium at a temperature of + 23°C. Results. Histological examination of the ovaries of group 1 rats revealed morphological changes in the ovaries characteristic of PCOS. The morphological structure of the ovaries corresponded to type II PCOS. In rats of group 3, macroscopically, the ovaries were slightly reduced in size compared to the control group. The levels of adiponectin and leptin as markers of the functional ovarian tissue of PCOS model experiments.When studying the effect of CE on the body of experimental animals, their effect on the formation of tissue cell hyperplasia as a characteristic sign of PCOS was determined. Conclusions. Studies have shown that the formation of PCOS, as well as structural changes in the ovaries, significantly depend on hormonal regulation disorders.
介绍。多囊卵巢综合征(PCOS)是妇科内分泌学研究的热点问题之一。本研究旨在探讨不同激素暴露对PCOS大鼠卵巢形态的影响。材料和方法。为了研究,开发了三个有效的实验模型,并将各种激素药物引入动物体内。模型I-st为含雌激素药物皮下注射,剂量为3mg,持续25天。模型II-d为每日皮下注射3mg硫酸脱氢雄烯二醇导致多囊卵巢综合征。III模型- 5只未成熟大鼠在皮下注射多巴胺植物类似物3mg,持续25天,形成多囊卵巢综合征。将实验动物分为3组:1组为实验性PCOS诱导大鼠,在+23°C的环境中饲养(n=8); 2组为实验性PCOS背景下,在+ 4°C恒定光照条件下冷暴露(CE) 4小时,持续25天(n=8);3组为未患多囊卵巢综合征的健康大鼠(n = 8),饲养于+ 23℃恒温箱内。结果。1组大鼠卵巢组织学检查显示PCOS卵巢形态学改变。卵巢形态结构符合II型多囊卵巢综合征。从宏观上看,3组大鼠卵巢尺寸较对照组略有缩小。脂联素和瘦素水平作为PCOS模型实验卵巢功能组织的标志物。在研究CE对实验动物身体的影响时,确定了CE对组织细胞增生形成的影响,这是PCOS的特征标志。结论。研究表明,多囊卵巢综合征的形成以及卵巢的结构变化在很大程度上取决于激素调节障碍。
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引用次数: 0
Investigating Machine Learning Approaches for Bitcoin Ransomware Payment Detection Systems 研究比特币勒索软件支付检测系统的机器学习方法
Pub Date : 2020-10-09 DOI: 10.38124/ijisrt20sep784
Kirat Jadhav
Cryptocurrencies have revolutionized the process of trading in the digital world. Roughly one decade since the induction of the first bitcoin block, thousands of cryptocurrencies have been introduced. The anonymity offered by the cryptocurrencies also attracted the perpetuators of cybercrime. This paper attempts to examine the different machine learning approaches for efficiently identifying ransomware payments made to the operators using bitcoin transactions. Machine learning models may be developed based on patterns differentiating such cybercrime operations from normal bitcoin transactions in order to identify and report attacks. The machine learning approaches are evaluated on bitcoin ransomware dataset. Experimental results show that Gradient Boosting and XGBoost algorithms achieved better detection rate with respect to precision, recall and F-measure rates when compared with k-Nearest Neighbor, Random Forest, Naïve Bayes and Multilayer Perceptron approaches
加密货币彻底改变了数字世界的交易过程。自第一个比特币区块出现大约十年以来,已经出现了数千种加密货币。加密货币提供的匿名性也吸引了网络犯罪的延续者。本文试图研究不同的机器学习方法,以有效识别使用比特币交易向运营商支付的勒索软件付款。机器学习模型可以基于将此类网络犯罪操作与正常比特币交易区分开来的模式来开发,以便识别和报告攻击。在比特币勒索软件数据集上对机器学习方法进行了评估。实验结果表明,与k-Nearest Neighbor、Random Forest、Naïve Bayes和Multilayer Perceptron方法相比,Gradient Boosting和XGBoost算法在准确率、召回率和F-measure率方面取得了更好的检测率
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引用次数: 0
Ameliorative Efficacy of Ethanolic Extracts of Curcuma longa (turmeric) Roots and Cassia occidentalis Leaves on Potassium Induced Kidney Damage in Albino Rats 姜黄根和决明子叶乙醇提取物对钾致白化大鼠肾损伤的改善作用
Pub Date : 2020-10-09 DOI: 10.38124/ijisrt20sep746
Nnama T.N, Anibueze C.I.P, Okwara B.O, Okafor M.C
The emphasis of harmful health challenges caused by preserved food or processed food is a global problem and the need to reduce its effect on the vital organs in the body has been the subject of great concern to researchers. The present study seeks to evaluate the efficacy of ethanolic extracts of Curcuma longa (turmeric) roots and Cassia occidentalis leaves on potassium induced kidney damage in albino rats. Fifty adult male rats weighing about 100g-200g classified into ten groups (I-X) were used in the study. Group1 served as control and were administered only with distilled water and rat feeds ad libitum all throughout the experiment. Group II served as negative (-ve) control and were administered 50mg/kg bodyweight of potassium bromate orally. Groups III, IV, VII and VIII received 50mg/kg bodyweight of potassium bromate for two weeks thereafter received 50mg/kg bodyweight with 500mg and 1000mg/kg body weight of ethanolic root extract of Curcuma longa and leaves extract Cassia occidentalis respectively for two weeks. Groups V, VI, and IX and X received 500mg and 1000mg/kg bodyweight of ethanolic root extract of Curcuma longa and leaves extract Cassia occidentalis for two weeks thereafter received 50mg/kg bodyweight of potassium bromate withethanolic root extract of Curcuma longa and leaves extract Cassia occidentalis respectively for two weeks. The rats at the end of 28 days were anaesthetised, blood samples were collected and the kidneys were harvested. The result of biochemical analysis revealed significant decrease in the level of biochemical parameters following administration of 500mg/ kg and 1000mg/kg body weight of Curcuma longa and Cassia occidentalis ethanolic leaf extract for curative and protective purpose when compared with group II (+ve control) that received 50mg/kg body weight of potassium bromate. Histological findings revealed restoration and protection of the extracts on the kidney architecture of male albino rats. Results obtained thus showed that oral administration of ethanolic root extracts of Curcuma longa and leaf extract of Cassia occidentalis may possess preventive and therapeutic purpose against kidney damage
腌制食品或加工食品对健康的危害是一个全球性的问题,如何减少其对人体重要器官的影响一直是研究人员非常关注的问题。本研究旨在评价姜黄根和决明子叶乙醇提取物对钾诱导的白化大鼠肾损伤的影响。50只体重约为100g-200g的成年雄性大鼠,分为10组(I-X)。第1组为对照组,在整个实验过程中只给予蒸馏水和大鼠饲料。II组为阴性(-ve)对照,口服溴酸钾50mg/kg体重。III组、IV组、VII组和VIII组分别给予50mg/kg体重的溴酸钾治疗2周,随后分别给予50mg/kg体重的姜黄根提取物和决明子叶提取物,分别给予500mg和1000mg/kg体重的乙醇提取物治疗2周。V组、VI组、IX组和X组分别给予姜黄根乙醇提取物和西决明子叶提取物500mg和1000mg/kg体重组2周,随后分别给予姜黄根乙醇提取物和西决明子叶提取物50mg/kg体重组溴酸钾2周。28 d后麻醉大鼠,取血取肾。生化分析结果显示,与给予50mg/kg体重溴酸钾的II组(+ve对照)相比,给予500mg/ kg和1000mg/kg体重姜黄和西桂花乙醇叶提取物具有治疗和保护作用的小鼠生化指标水平显著降低。组织学结果显示,提取物对雄性白化大鼠肾脏结构有修复和保护作用。由此可见,口服姜黄根提取物和决明子叶提取物具有预防和治疗肾损害的作用
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引用次数: 0
Electronic Commerce: Validity of the Digital Contract Based on Indonesia Legislation Perspective 电子商务:基于印尼立法视角的数字合同有效性
Pub Date : 2020-10-07 DOI: 10.38124/ijisrt20sep412
Sunaryo, Hanifah Nuraini
Technological developments in the economic sector, a transaction renewal known as electronic commerce. Transactions that occur in e-commerce are categorized as digital contracts. The use of digital contracts in Indonesia does not escape a number of problems, which is legal. Legal issues that appear in this digital transaction are related to the element of validity. Digital contracts as a new type of contract cannot be equated with conventional contracts, because there are different limitations. This condition resulted in the implementation of digital contracts being facilitated thoroughly by regulations. This paper will examine legal issues in the implementation of digital contracts and understand the legality of digital contracts based on legal instruments in Indonesia.
经济领域的技术发展,一种交易更新称为电子商务。电子商务中的交易被归类为数字合同。在印度尼西亚使用数字合同并没有逃避一些合法的问题。在这种数字交易中出现的法律问题与有效性要素有关。数字合同作为一种新型的合同类型,不能等同于传统合同,因为它有不同的局限性。这种情况导致法规彻底促进了数字合同的实施。本文将研究数字合同实施中的法律问题,并根据印度尼西亚的法律文书了解数字合同的合法性。
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引用次数: 0
The Influence of Ownership Structure and Income Management on Corporate Social Responsibility Disclosure 股权结构与收益管理对企业社会责任披露的影响
Pub Date : 2020-10-05 DOI: 10.38124/ijisrt20sep722
F. F. Farhah, Iranti Safriyana
The purpose of this study is to provide evidence of the influence of managerial ownership, institutional ownership, foreign ownership, and earnings management of corporate social responsibility disclosure. The sample used was 15 companies with a purposive sampling method. The data used in this study uses secondary data in the form of annual financial reports and annual reports of manufacturing companies listed on the Indonesia Stock Exchange 2014-2017. The study results found that managerial ownership, institutional ownership, and earnings management have no significant impact on corporate social responsibility disclosure. However, foreign ownership has a significant effect on corporate social responsibility disclosure.
本研究的目的是为管理层持股、机构持股、外资持股和盈余管理对企业社会责任披露的影响提供证据。采用有目的的抽样方法,选取15家公司作为样本。本研究使用的数据采用的二手数据为2014-2017年在印尼证券交易所上市的制造业公司年度财务报告和年报。研究结果发现,管理层持股、机构持股和盈余管理对企业社会责任披露没有显著影响。外资持股对企业社会责任披露有显著影响。
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引用次数: 0
Role of CRISPR/Cas9 in Genetic Manipulation of ROS1 and EGFR Genes using Synthego Platform CRISPR/Cas9在合成平台上对ROS1和EGFR基因进行基因操作中的作用
Pub Date : 2020-10-05 DOI: 10.38124/ijisrt20sep592
M. Goenka, Aniket De, A. Biswas
Mutations and fusions in kinase enzymes are often observed in cancer prognosis. The growth and survival of tumor cells depend on the activation of kinase enzymes which when activated unrestrained can lead to the uncontrolled division of malignant lung cells. Thus, their inhibition is viewed as a promising and effective anti-cancer therapy. ROS1 and EGFR are two tyrosine kinases that have been explored as the genes responsible for Non-Small Cell Lung Cancer (NSCLC). By interrupting the unchecked division of these genes, the development of malignant lung cancer cells can be blocked. The results show 4 of the top-line RNAs for altering the gene quality as well as the target sequences relevant to cleavage by that gRNA, 4 for each gene. We propose a genetic approach of controlling the ROS1 and EGFR genes guided by CRISPR/Cas-9 to guarantee fewer symptoms and an increasingly powerful treatment, by the use of computational tools.
激酶的突变和融合在癌症预后中经常被观察到。肿瘤细胞的生长和存活依赖于激酶的激活,当激酶被无限制激活时,可导致恶性肺细胞不受控制的分裂。因此,它们的抑制被认为是一种有前途和有效的抗癌治疗方法。ROS1和EGFR是两种酪氨酸激酶,被认为是导致非小细胞肺癌(NSCLC)的基因。通过阻断这些基因不受控制的分裂,恶性肺癌细胞的发展就可以被阻断。结果显示有4个顶级rna可以改变基因质量,以及与该gRNA切割相关的靶序列,每个基因4个。我们提出了一种由CRISPR/Cas-9引导的控制ROS1和EGFR基因的遗传方法,通过使用计算工具来保证更少的症状和越来越强大的治疗。
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引用次数: 0
Oral Health Care Behavior Differences Between Dental and Biomedical Engineering Students Comparing Oral Care of Dental and Engineering Students 牙科与生物医学工程专业学生口腔保健行为差异比较
Pub Date : 2020-10-03 DOI: 10.38124/IJISRT20SEP590
Ayşe Koçak-Büyükdere, Sarkis Sözkes, M. Bozkurt
The aim of the study was to compare the oral hygiene habits of students from different provinces and universities, from the dental faculty and biomedical engineering. Another aim was to analyze development of dental care habits during growth in relation to education both the parent and the student himself. University students were asked to answer the survey on voluntary basis. 244 students have answered the questions; gender, year of birth, study level, education of their parents, their toothbrushing habit and oral health level awareness were questioned in detail. Of the 244 volunteers, 122 study at the faculty of dentistry, whereas the other 122 study at the biomedical engineering faculty. While 53.7% of all participants brush their teeth after breakfast and 94.3% brush before bedtime, 81.1% of dentistry students brush twice a day, whereas the ratio of biomedical students brushing twice a day is 59.8%. On the one hand, 99.2% of dentistry students brush their teeth before going to bed whereas, biomedical students were 89.3%, which indicates a significant difference. Dental floss utilization among dental students was higher than the biomedical students, and the difference was statistically significant. For self-assessment of their oral hygiene habits, both groups have evaluated themselves between ordinary and well. Tooth brushing habit is initially adopted from the family. Correct brushing is established upon the guidance of the dentist. Therefore, teaching proper toothbrushing techniques to the families should be aimed. This will enable socially healthier oral hygiene, thus creating high awareness communities
该研究的目的是比较来自不同省份和大学,来自牙科学院和生物医学工程的学生的口腔卫生习惯。另一个目的是分析在成长过程中与父母和学生本人的教育有关的牙齿护理习惯的发展。大学生被要求在自愿的基础上回答调查。244名学生回答了问题;详细询问性别、出生年份、学习程度、父母受教育程度、刷牙习惯和口腔健康意识。在244名志愿者中,122人在牙科学院学习,而另外122人在生物医学工程学院学习。早餐后刷牙的比例为53.7%,睡前刷牙的比例为94.3%,牙科学生每天刷牙两次的比例为81.1%,生物医学学生每天刷牙两次的比例为59.8%。一方面,牙科学生睡前刷牙的比例为99.2%,而生物医学学生睡前刷牙的比例为89.3%,两者差异显著。牙线使用率牙科专业学生高于生物医学专业学生,差异有统计学意义。对于口腔卫生习惯的自我评价,两组的评价都在一般和良好之间。刷牙的习惯最初是从家庭中养成的。正确的刷牙是在牙医的指导下建立起来的。因此,向家庭教授正确的刷牙技巧应该是目标。这将促进社会上更健康的口腔卫生,从而建立高意识的社区
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引用次数: 0
Evaluation of Just in Time Implementation and Total Quality Management Using Confirmatory Factor Analysis 用验证性因子分析评价准时交货实施和全面质量管理
Pub Date : 2020-10-03 DOI: 10.38124/IJISRT20SEP510
Irawati Nursaningsih, Niken Sulistyowati
There are research gaps and phenomena that occur in the era of globalization need to be done research that aims to know and evaluate the implementation of Just in time (JIT) and Total Quality Management (TQM) using Confirmatory Factor Analysis (CFA). The research was conducted at PT. XYZ. Resources are obtained through field observations, interviews, documentation and questionnaires using a sample of 180 respondents. Data is obtained from primary and secondary data sources. According to the level of explanation including qualitative descriptive research. The analysis technique used is descriptive analysis using Confirmatory Factor Analysis (CFA). The results showed that PT. XYZ has implemented JIT and TQM only found a few obstacles. This research has implications on managerial policy and can be used by management in determining company policies to produce JIT and TQM which both CFA Test Results show the highest standardize estimated value exists in the flexible workforce dimension which is the right way especially in the JIT section and an important initial role before the implementation process where the main focus is employees. While the implementation of good TQM the highest standardize estimated value is in the respect for employee’s dimension which is the right way especially in the TQM section.
在全球化时代出现的研究空白和现象需要进行研究,旨在利用验证性因子分析(CFA)了解和评价准时制(JIT)和全面质量管理(TQM)的实施。这项研究是在PT. XYZ进行的。资源是通过实地观察、访谈、文件和使用180名答复者抽样的调查表获得的。数据来自主要和次要数据源。根据层次解释包括定性描述性研究。使用的分析技术是使用验证性因子分析(CFA)的描述性分析。结果表明,PT. XYZ已经实现了JIT, TQM只发现了一些障碍。本研究对管理政策有影响,可以被管理层用于确定公司政策,以产生JIT和TQM,这两个CFA测试结果都表明,在灵活的劳动力维度中存在最高的标准化估计值,这是正确的方式,特别是在JIT部分,在主要关注员工的实施过程之前,它是一个重要的初始角色。而良好的TQM的实施,最高的标准化估值是在对员工维度的尊重,这是正确的方式,特别是在TQM部分。
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引用次数: 0
Vietnamese Tourist Attraction in Term of AgroTourism Development, a Case Study at Tra Que Village, Quang Nam Province, Viet Nam 从农业旅游发展的角度看越南的旅游吸引力——以越南广南省特克村为例
Pub Date : 2020-10-03 DOI: 10.38124/IJISRT20SEP586
Ha Van Trung, S. Simaraks
Agro-tourism is a form of rural tourism that has actively developed in recent years. Tra Que Vegetable Village has developed this type of tourism to meet the needs of visitors to visit and experience. However, Vietnamese tourists to experience agrotourism here are very few. The purpose of this study is to find out and determine the level of attraction to Vietnamese tourists in agro-tourism in Tra Que vegetable village. Participants responded questionnaire of the survey in term of participation levels in agricultural activities, and assessment of service quality and tourist's satisfaction reflecting after participating in the agro-tourism experience. The results indicate that most of the tourists participate partly in agricultural activities, the quality of service is good, and the level of visitor satisfaction is high. In general, the ability to attract Vietnamese tourists to agricultural tourism is high. Increasing visitor participation in agri-tourism activities will further enhance the ability to attract Vietnamese tourists in Tra Que Vegetable Village.
农业旅游是近年来蓬勃发展起来的一种乡村旅游形式。特阙蔬菜村开发了这类旅游,以满足游客参观和体验的需求。然而,来这里体验农业旅游的越南游客却很少。本研究的目的是找出并确定特克蔬菜村农业旅游对越南游客的吸引力水平。被调查对象分别就农业活动参与程度、参与农业旅游体验后反映的服务质量评价和游客满意度进行问卷调查。结果表明:游客大部分部分参与农业活动,服务质量较好,游客满意度较高。总的来说,农业旅游吸引越南游客的能力很高。增加游客对农业旅游活动的参与,将进一步提高特克蔬菜村吸引越南游客的能力。
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引用次数: 0
Analysis of Preterm Induction of Labour 早产引产分析
Pub Date : 2020-10-02 DOI: 10.38124/IJISRT20SEP618
Kritika Agrawal, Shubhangi Mande, Lakshmi Rachakonda
Worldwide 20-30% of labour cases are induced. We conducted an analysis to evaluate the success of labour induction for indicated preterm birth A prospective observational study was conducted among 50 patients admitted in the Department of OBGY, MGM Medical College and Hospital, Aurangabad from 1st March 2019 to 31st March 2020. There was a total of 50 deliveries during this period. The preterm induction majorly includes 20-34 years as this is the commonest reproductive age group seen in our hospital. More number of Hindus underwent induction. Multigravida requires induction more as compared to primigravida. More number of patients were induced between 32-36 weeks, reason being PPROM, severe preeclampsia, IUD and severe FGR. Vaginal delivery is more likely irrespective of bishop score. Induction of labour remains relevant obstetrics procedure and its outcome will depend on proper choice of patients and close intrapartum monitoring
全世界20-30%的分娩病例是引产。我们对2019年3月1日至2020年3月31日在奥兰加巴德米高梅医学院和医院产科收治的50例患者进行了前瞻性观察研究。在此期间共接生了50次。早产主要包括20-34岁,因为这是我们医院最常见的生育年龄组。更多的印度教徒接受了入籍。与初孕相比,多孕需要更多的诱导。在32-36周期间,以PPROM、重度先兆子痫、宫内节育器、重度FGR为诱发原因的患者较多。无论主教评分如何,阴道分娩的可能性更大。引产仍然是相关的产科程序,其结果将取决于患者的正确选择和密切的产时监测
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引用次数: 0
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Volume 5 - 2020, Issue 9 - September
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