Pub Date : 2017-11-01DOI: 10.20959/WJPR201711-9129
M. Khan
A 12-year-old Indian male patient presented with difficulty in mouth opening. He had also given the history of burning sensation during eating. Patient had given the history of SWEETY SUPARI chewing. On intra oral examination, blanching was present on faucial area, right and left buccal mucosa. On palpation fibrotic bands were palpable in right and left buccal mucosa. On the basis of clinical examination and habit history the patient was diagnosed with oral submucous fibrosis. A comprehensive treatment plan was made based on conservative management. Patient was advised to quit the bad habit of chewing SWEETY SUPARI. Vitamin B complex supplements, antioxidants, multivitamins along with Triamcinolone Acetonide 0.1% were prescribed. Oral physiotherapy was also advised. Patient was advised to take green vegetables and non-spicy food along with orange juice. World Journal of Pharmaceutical Research SJIF Impact Factor 7.523 Volume 6, Issue 11, 447-452. Case Report ISSN 2277– 7105 Article Received on 27 July 2017, Revised on 16 August 2017, Accepted on 05 Sept. 2017 DOI: 10.20959/wjpr201711-9129 *Corresponding Author Dr. Mobeen Khan Senior Lecturer, Department of Oral medicine and Radiology, Chandra Dental College and Hospital Barabanki, Uttar Pradesh, India.
{"title":"ORAL SUBMUCOUS FIBROSIS IN 12 YEAR OLD BOY: A RARE CASE REPORT","authors":"M. Khan","doi":"10.20959/WJPR201711-9129","DOIUrl":"https://doi.org/10.20959/WJPR201711-9129","url":null,"abstract":"A 12-year-old Indian male patient presented with difficulty in mouth opening. He had also given the history of burning sensation during eating. Patient had given the history of SWEETY SUPARI chewing. On intra oral examination, blanching was present on faucial area, right and left buccal mucosa. On palpation fibrotic bands were palpable in right and left buccal mucosa. On the basis of clinical examination and habit history the patient was diagnosed with oral submucous fibrosis. A comprehensive treatment plan was made based on conservative management. Patient was advised to quit the bad habit of chewing SWEETY SUPARI. Vitamin B complex supplements, antioxidants, multivitamins along with Triamcinolone Acetonide 0.1% were prescribed. Oral physiotherapy was also advised. Patient was advised to take green vegetables and non-spicy food along with orange juice. World Journal of Pharmaceutical Research SJIF Impact Factor 7.523 Volume 6, Issue 11, 447-452. Case Report ISSN 2277– 7105 Article Received on 27 July 2017, Revised on 16 August 2017, Accepted on 05 Sept. 2017 DOI: 10.20959/wjpr201711-9129 *Corresponding Author Dr. Mobeen Khan Senior Lecturer, Department of Oral medicine and Radiology, Chandra Dental College and Hospital Barabanki, Uttar Pradesh, India.","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"30 1","pages":"447-452"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74455736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/WJPR201711-9541
Sazid Ali
A series of novel biphenyl derivatives of benzimidazole (PA-824 analogues) as anti-tubercular agents was synthesised, characterised and evaluated for their anti-mycobacterial activity, by using an in silico design and 3D-QSAR-driven approach. Initially, we developed SAR rules and 3D-QSAR models using literature data for targeted design of new biphenyl derivatives of PA-824 analogues with anti-TB activity. Using these models, we prioritized 12 compounds for synthesis and biological evaluation. As a result compound 6c & 6d were 2.5 and 2 fold more active against M. tuberculosis when compared to the standard drug RMP (MICs of 0.04 and 0.05 μg mL-1 respectively) while compound 6e & 6f having 3-fluoro-4-methoxy and 3-fluoro-4-trifluoromethoxy groups at ring B were found to be equally potent to standard drug RMP (MICs of 0.09 and 0.12 μg mL-1 respectively).
{"title":"3D-QSAR DRIVEN DESIGN, SYNTHESIS AND EVALUATION OF NOVEL BIPHENYL DERIVATIVES OF BENZIMIDAZOLE (PA-824 ANALOGUES) AS ANTI-TUBERCULAR AGENTS","authors":"Sazid Ali","doi":"10.20959/WJPR201711-9541","DOIUrl":"https://doi.org/10.20959/WJPR201711-9541","url":null,"abstract":"A series of novel biphenyl derivatives of benzimidazole (PA-824 analogues) as anti-tubercular agents was synthesised, characterised and evaluated for their anti-mycobacterial activity, by using an in silico design and 3D-QSAR-driven approach. Initially, we developed SAR rules and 3D-QSAR models using literature data for targeted design of new biphenyl derivatives of PA-824 analogues with anti-TB activity. Using these models, we prioritized 12 compounds for synthesis and biological evaluation. As a result compound 6c & 6d were 2.5 and 2 fold more active against M. tuberculosis when compared to the standard drug RMP (MICs of 0.04 and 0.05 μg mL-1 respectively) while compound 6e & 6f having 3-fluoro-4-methoxy and 3-fluoro-4-trifluoromethoxy groups at ring B were found to be equally potent to standard drug RMP (MICs of 0.09 and 0.12 μg mL-1 respectively).","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"92 1","pages":"687-701"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80413272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/wjpr201711-9108
K. Mali
{"title":"REVIEW OF DINCHARYA IN BRAHTRAEE","authors":"K. Mali","doi":"10.20959/wjpr201711-9108","DOIUrl":"https://doi.org/10.20959/wjpr201711-9108","url":null,"abstract":"","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"18 1","pages":"148-156"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75516821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/WJPR201711-9540
M. I. Malik
{"title":"PHYSICIAN SUBCONSCIOUS (PERSONAL/PSYCHOLOGICAL) FACTORS AND THEIR ROLE IN INFLUENCING PRESCRIPTION PATTERN IN DELHI NCR HEALTHCARE SETUPS: A RETROSPECTIVE CROSS-SECTIONAL STUDY","authors":"M. I. Malik","doi":"10.20959/WJPR201711-9540","DOIUrl":"https://doi.org/10.20959/WJPR201711-9540","url":null,"abstract":"","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"40 1","pages":"676-686"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74176783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/WJPR201711-9061
S. Parveen
Organophosphorus compounds are highly effective insecticides, though some are also lethal to humans at minute exposure. A case of organophosphate poisoning is presented in which a pregnant women consumed organophosphorus compound and treated with antidotes and other drugs. Mean while we found adverse drug reaction for a drug T. Escitalopram 10mg, BD. We reported it to the health care professionals and the same was focused in this case. The suspected ADR was Probable ADR (Naranjo's scale). After doing intervention the patient was recovered and discharged safely.
{"title":"A CASE REPORT ON OP POISONING DURING PREGNANCY","authors":"S. Parveen","doi":"10.20959/WJPR201711-9061","DOIUrl":"https://doi.org/10.20959/WJPR201711-9061","url":null,"abstract":"Organophosphorus compounds are highly effective insecticides, though some are also lethal to humans at minute exposure. A case of organophosphate poisoning is presented in which a pregnant women consumed organophosphorus compound and treated with antidotes and other drugs. Mean while we found adverse drug reaction for a drug T. Escitalopram 10mg, BD. We reported it to the health care professionals and the same was focused in this case. The suspected ADR was Probable ADR (Naranjo's scale). After doing intervention the patient was recovered and discharged safely.","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"39 1","pages":"442-446"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88667744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/WJPR201711-9266
Vd. Suhas U. Sakhare
{"title":"HOLISTIC APPROACH OF AYURVEDA IN GERIATRICS: REVIEW ARTICLE","authors":"Vd. Suhas U. Sakhare","doi":"10.20959/WJPR201711-9266","DOIUrl":"https://doi.org/10.20959/WJPR201711-9266","url":null,"abstract":"","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"45 1","pages":"167-174"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90918545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/WJPR201711-9403
D. Geeta
{"title":"GUGGULU: A PRECIOUS HERB (REVIEW ARTICLE)","authors":"D. Geeta","doi":"10.20959/WJPR201711-9403","DOIUrl":"https://doi.org/10.20959/WJPR201711-9403","url":null,"abstract":"","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"1 1","pages":"175-179"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82997000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/WJPR201711-9607
L. Vennila
Cardiovascular diseases (CVDs) and their risk factors are major contributors to global morbidity and mortality. CVDs are associated with oxidative stress, leading to an increased production of reactive oxygen species (ROS), including superoxide radical, hydrogen peroxide, and hydroxyl radical or reduction of antioxidant defense system. These reactive species attack biomolecules such as lipids, DNA, and proteins enhancing the previously established tissue damage, as well as triggering cell death pathways. Hypercholesterolemia, high concentration of low-density lipoprotein cholesterol (LDL-C), very low density lipoprotein-cholesterol (VLDLC), hypertriglyceridemia and low high-density lipoprotein (HDL-C) are also the independent risk factors for atherosclerotic CVDs. In this review, we propose a systematic approach to the cardioprotective effect of sesame oil that could offer a novel therapeutic opportunity against this oxidative tissue damage. Sesame seeds and oil have long been categorized as traditional health food in India and other East Asian countries and it is one of the major cooking oil used in human diet. Sesame oil supplementation decreased serum TC, LDL-C and lipid peroxidation, and increased antioxidant status in hyperlipidemic patients. Sesame oil, in comparison to other dietary oils such as ground nut and sunflower, also offers better protection against increased BP, hyperlipidemia and lipid peroxidation by increasing enzymatic and non-enzymatic antioxidants. This review addresses the recent findings of cardioprotective potentials of sesame oil.
{"title":"CARDIOPROTECTIVE EFFECT OF SESAME OIL: A REVIEW","authors":"L. Vennila","doi":"10.20959/WJPR201711-9607","DOIUrl":"https://doi.org/10.20959/WJPR201711-9607","url":null,"abstract":"Cardiovascular diseases (CVDs) and their risk factors are major contributors to global morbidity and mortality. CVDs are associated with oxidative stress, leading to an increased production of reactive oxygen species (ROS), including superoxide radical, hydrogen peroxide, and hydroxyl radical or reduction of antioxidant defense system. These reactive species attack biomolecules such as lipids, DNA, and proteins enhancing the previously established tissue damage, as well as triggering cell death pathways. Hypercholesterolemia, high concentration of low-density lipoprotein cholesterol (LDL-C), very low density lipoprotein-cholesterol (VLDLC), hypertriglyceridemia and low high-density lipoprotein (HDL-C) are also the independent risk factors for atherosclerotic CVDs. In this review, we propose a systematic approach to the cardioprotective effect of sesame oil that could offer a novel therapeutic opportunity against this oxidative tissue damage. Sesame seeds and oil have long been categorized as traditional health food in India and other East Asian countries and it is one of the major cooking oil used in human diet. Sesame oil supplementation decreased serum TC, LDL-C and lipid peroxidation, and increased antioxidant status in hyperlipidemic patients. Sesame oil, in comparison to other dietary oils such as ground nut and sunflower, also offers better protection against increased BP, hyperlipidemia and lipid peroxidation by increasing enzymatic and non-enzymatic antioxidants. This review addresses the recent findings of cardioprotective potentials of sesame oil.","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"33 1","pages":"331-341"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90369664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/WJPR201711-9592
Dip S. Kondhia
{"title":"REVIEW ON NANOCRYSTAL","authors":"Dip S. Kondhia","doi":"10.20959/WJPR201711-9592","DOIUrl":"https://doi.org/10.20959/WJPR201711-9592","url":null,"abstract":"","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"6 1","pages":"293-311"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75233610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/WJPR201711-9415
D. Bhatt
There is no known cure for multiple sclerosis. Treatments attempt to improve function after an attack and prevent new attacks. Medications used to treat MS, while modestly effective, can have side effects and be poorly tolerated Multiple sclerosis usually starts with an acute episode of neurological disturbance, termed a 'clinically isolated syndrome', followed by an illness phase punctuated by relapses and remissions which may transition after 10 years to a phase of progressive accumulation of disability without relapses. Fifteen to 20% of patients will have a progressive course from the onset. There is significant interpatient variability in prognosis. The main diagnostic criteria are clinical, supported by investigations including magnetic resonance imaging and lumbar puncture and evoked potentials. First line disease modifying agents for relapsing remitting multiple sclerosis include interferon-ß and glatiramer. First line treatment for relapses is usually intravenous methylprednisolone for 3 days. Troublesome symptoms may include spasticity, parasthesias, tremor, erectile dysfunction, depression and anxiety, fatigue and pain. After excluding differential diagnoses, symptomatic management includes pharmacological agents, allied health consultation and continence strategies. Although pregnancy reduces disease activity, there is a higher risk of relapse in the postpartum period.
{"title":"BRIEF REVIEW ON MULTIPLE SCLEROSIS","authors":"D. Bhatt","doi":"10.20959/WJPR201711-9415","DOIUrl":"https://doi.org/10.20959/WJPR201711-9415","url":null,"abstract":"There is no known cure for multiple sclerosis. Treatments attempt to improve function after an attack and prevent new attacks. Medications used to treat MS, while modestly effective, can have side effects and be poorly tolerated Multiple sclerosis usually starts with an acute episode of neurological disturbance, termed a 'clinically isolated syndrome', followed by an illness phase punctuated by relapses and remissions which may transition after 10 years to a phase of progressive accumulation of disability without relapses. Fifteen to 20% of patients will have a progressive course from the onset. There is significant interpatient variability in prognosis. The main diagnostic criteria are clinical, supported by investigations including magnetic resonance imaging and lumbar puncture and evoked potentials. First line disease modifying agents for relapsing remitting multiple sclerosis include interferon-ß and glatiramer. First line treatment for relapses is usually intravenous methylprednisolone for 3 days. Troublesome symptoms may include spasticity, parasthesias, tremor, erectile dysfunction, depression and anxiety, fatigue and pain. After excluding differential diagnoses, symptomatic management includes pharmacological agents, allied health consultation and continence strategies. Although pregnancy reduces disease activity, there is a higher risk of relapse in the postpartum period.","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"7 1","pages":"180-194"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74251617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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