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A CASE STUDY OF DUSHTA VRANA (CHRONIC WOUND) TREATED WITH PRIYANGVADI TAILA 普扬瓦地治疗慢性伤口一例
Pub Date : 2017-11-01 DOI: 10.20959/wjpr201711-9619
A. Sharma
Chronic wound (ie. Dushta vrana) is one of the very serious issues faced by the health care professionals around the world. Normally a healthy wound heals timely itself with minimum scar formation and damage to skin as compared to those infected or contaminated. So all efforts are made in to keep the wound healthy and clean in all stages of its healing. A wound is said to be chronic/non healing if it does not heal through normal set of stages and in predictable amount of time. A lot of treatments modalities have been developed by modern science for the management of wound, but either it leave harmful side effects behind or they leave a financial burden on the patients. In India a large part of population lies below poverty line and cannot afford such costly treatments. Keeping this in sense, Priyangvadi Taila could be a better option for treating Dushta vrana (chronic/non healing wound). A case report of 20 year – young boy, who presented with complaints of an open wound on the anterior aspect of his right leg associated with pain, discharge, slough, odour, edema, discoloration of the skin and with a history of six years has been discussed here.
慢性伤口。Dushta vrana)是世界各地卫生保健专业人员面临的非常严重的问题之一。正常情况下,与感染或污染的伤口相比,健康的伤口会及时愈合,疤痕形成和皮肤损伤最小。因此,在伤口愈合的各个阶段,都要尽一切努力保持伤口的健康和清洁。如果伤口没有经过正常的阶段和可预测的时间愈合,就被称为慢性/不可愈合。现代科学已经开发了许多治疗伤口的方法,但要么留下了有害的副作用,要么给病人留下了经济负担。在印度,很大一部分人口生活在贫困线以下,负担不起如此昂贵的治疗费用。从这个意义上讲,Priyangvadi Taila可能是治疗Dushta vrana(慢性/不愈合伤口)的更好选择。一个20岁的年轻男孩的病例报告,谁提出主诉一个开放的伤口在他的右腿前部,并伴有疼痛,分泌物,脱屑,气味,水肿,皮肤变色,有6年的历史,在这里讨论。
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引用次数: 0
PILATES AND PHYSIOTHERAPY ON HAMSTRING TIGHTNESS – AN EVIDENCE BASED CASE STUDY 普拉提和物理治疗腿筋紧绷-一个基于证据的案例研究
Pub Date : 2017-11-01 DOI: 10.20959/wjpr201711-9624
S. S. Subramanian
Elderly population and their health care needs life expectancy. Musculoskeletal conditions such as low backache, osteoarthritis of knee joints are common clinical entities recorded among geriatric subjects. This research aims to analyse Pilates and physiotherapy treatment on a subject with lowback ache, early knee osteoarthritis and bilateral. Hamstring Tightness Materials & Methodology: This research where 65 year old subject was treated for bilateral hamstring tightness, lowback ache and osteoarthritis knee in Chennai during the period from March 2017 to April 2017. Specific Pilates and physiotherapy exercises with weekly twice frequency. Results: pre and post VAS (P<.05), Womac (P<.05) and Oswestry score (P<.001) were recorded and statistically analyzed. Conclusion: An improved knee and lowback functions of life as reflected among this study subject with specific Pilates and physiotherapy lessens dependency, increase dignity and self esteem, hence an enhanced quality of life of this geriatric subject was evidenced.
老年人口及其保健需要预期寿命。肌肉骨骼疾病,如腰痛,膝关节骨关节炎是常见的临床实体记录在老年受试者。本研究的目的是分析普拉提和物理治疗的主题与腰痛,早期膝骨关节炎和双侧。材料与方法:本研究于2017年3月至2017年4月在金奈对65岁的受试者进行了双侧腘绳肌紧绷,腰背疼痛和膝关节骨关节炎的治疗。有针对性的普拉提和理疗练习,每周两次。结果:记录VAS前后评分(P< 0.05)、Womac评分(P< 0.05)、Oswestry评分(P< 0.001),并进行统计学分析。结论:通过特定的普拉提和物理治疗,本研究对象的膝关节和下背部功能得到改善,依赖性减少,尊严和自尊增加,因此证明了该老年受试者的生活质量提高。
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引用次数: 0
PHARMACEUTICALLY RELEVANT CuNP, PbNP AND LiNP FROM ASPERGILLUS SPECIES 从曲霉种中提取的药学上相关的CuNP、PbNP和LiNP
Pub Date : 2017-11-01 DOI: 10.20959/WJPR201711-9473
Mirza Farhana Ishaque, Nabila Anwar Patrawala, Dr. D. R. Majumder
The microorganisms showed the unique potential in the production and accumulation of nano metals with different shapes and sizes by „bioleaching‟. The biological system – Aspergillus species a fungus, isolated from soil was capable of synthesizing nanoparticles such as lithium, lead, and copper using LiCl3 (0.025M), Pb(NO3)2 (0.0002M), and CuSO4(0.025M) as a precursor metal salt. The morphology and the size of the synthesized nano metals as per Scanning Electron Microscopy micrograph confirmed the formation of LiNPs with 85 nm – 100 nm size range, CuNPs with 80 nm – 86 nm in range and PbNPs with 70 nm – 95 nm in range and all three were almost spherical in shape. These nano Metals were further characterized by UV Visible Spectrophotometry, Xray differaction analysis, Fourier Transform Infrared analysis, Cyclic Voltammetry. The ability of these nanoparticles in the field of electronics for the use in batteries were also tested. This green synthesis at room temperature was the most ecofriendly way to produce nano metals.
微生物通过“生物浸出”在不同形状和大小的纳米金属的生产和积累中显示出独特的潜力。从土壤中分离出来的真菌曲霉能够以LiCl3 (0.025M)、Pb(NO3)2 (0.000m)和CuSO4(0.025M)作为前体金属盐合成锂、铅和铜等纳米颗粒。扫描电镜观察了合成的纳米金属的形貌和尺寸,结果表明:LiNPs的尺寸范围为85 nm ~ 100 nm, CuNPs的尺寸范围为80 nm ~ 86 nm, PbNPs的尺寸范围为70 nm ~ 95 nm,三者的形状均接近球形。采用紫外可见分光光度法、x射线衍射法、傅里叶变换红外光谱法、循环伏安法对纳米金属进行了进一步表征。这些纳米颗粒在电子领域的电池应用能力也进行了测试。这种在室温下的绿色合成是生产纳米金属的最环保的方法。
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引用次数: 0
PHARMACOGNOSTICAL PROFILE OF SCAEVOLA TACCADA (GAERTN.) ROXB. (LEAF AND STEM) - AN EXTRAPHARMACOPOEIAL DRUG. 山葵的生药学特征ROXB。(叶和茎)-一种药外药物。
Pub Date : 2017-11-01 DOI: 10.20959/wjpr201711-9498
Madhur Rai
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引用次数: 1
REGULATION OF REVERSE DISTRIBUTION OF CONTROLLED SUBSTANCES IN UNITED STATES 管制物质在美国反向分销的管制
Pub Date : 2017-11-01 DOI: 10.20959/WJPR201711-9600
M. G. Moniveena
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引用次数: 0
FORMULATION AND EVALUATION OF MICROSPONGES OF DICLOFENAC SODIUM 双氯芬酸钠微海绵的制备及评价
Pub Date : 2017-11-01 DOI: 10.20959/WJPR201711-8739
V. Manoj
Diclofenac sodium containing micro sponge as active constituent (API) in different formulations by changing the proportions of drug (diclofenac sodium), polymer (ethyl cellulose), emulsifier (Poly vinyl alcohol) were obtained successfully using quasi-emulsion solvent diffusion method.The micro sponges formulations were prepared by quasi emulsion solvent diffusion method employing ethyl cellulose as a polymer. The compatibility of the drug with formulation components was established by Fourier Transform Infra-Red (FTIR) spectroscopy. The surface morphology, particle size, production yield, and drug entrapment efficiency of micro sponges were examined. Shape and surface morphology of the micro sponges were examined using scanning electron microscopy. Particle size of prepared micro sponges was observed in the range of 28.7 ± 1.02 to 23.9 ± 1.19 μm. Scanning electron microscopy revealed the porous, spherical nature of the micro sponges. SEM photographs revealed the spherical nature of the micro sponges in all variations; however, at higher ratios, drug crystals were observed on the micro sponge surface. Increase in the drug/polymer ratio (1:1 to 1:10) increased their yield (10.85 ± 1.60 to 41.03 ± 1.26), average particle size of all formulations ranges from 28.7 μm to 45.9 μm which is in increasing order due to the increase in the concentration of polymer but after certain concentration it was observed that as the ratio of drug to polymer was increased, the particle size decreased, the drug content of different formulations was found in the range 19.07 ± 2.21 to 33.09 ±2.27, the cumulative release of the formulations are in the range of 89.83% to 13.25%. World Journal of Pharmaceutical Research SJIF Impact Factor 7.523 Volume 6, Issue 11, 417-429. Research Article ISSN 2277– 7105 Article Received on 25 July 2017, Revised on 15 August 2017, Accepted on 04 Sept. 2017 DOI: 10.20959/wjpr201711-8739
采用准乳液溶剂扩散法,通过改变药物(双氯芬酸钠)、聚合物(乙基纤维素)、乳化剂(聚乙烯醇)的比例,成功地获得了以微海绵为活性成分的双氯芬酸钠的不同配方。以乙基纤维素为聚合物,采用准乳液溶剂扩散法制备了微海绵配方。采用傅里叶变换红外光谱(FTIR)确定了药物与制剂成分的配伍性。考察了微海绵的表面形貌、粒径、产率和药物包封效率。用扫描电镜观察了微海绵的形状和表面形貌。所得微海绵的粒径范围为28.7±1.02 ~ 23.9±1.19 μm。扫描电子显微镜显示了微海绵的多孔性和球形性质。扫描电镜照片显示了所有变化的微海绵的球形性质;然而,在较高的比例下,在微海绵表面观察到药物晶体。增加药物/聚合物比例(1:1 1:10)增加了收益率(10.85±1.60,41.03±1.26),平均粒度的配方范围从28.7μm 45.9μm的增加订单由于聚合物的浓度的增加,但在某些浓度是观察药物聚合物的比例增加时,粒子尺寸下降,不同配方的药物内容被发现在19.07±2.21,33.09±2.27,制剂的累积释放度在89.83% ~ 13.25%之间。World Journal of Pharmaceutical Research, SJIF影响因子7.523,第6卷,第11期,417-429。文章收稿于2017年7月25日,修订于2017年8月15日,收稿于2017年9月4日DOI: 10.20959/wjpr201711-8739
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引用次数: 0
AN EXPERIMENTAL STUDY OF THE TOXICITY EFFECTS OF CALOTROPIS PROCERA (AITON) ASCLEPIADACEAE IN SPRAGUE-DAWLEY RATS 牛角霉对sd - dawley大鼠毒性的实验研究
Pub Date : 2017-11-01 DOI: 10.20959/WJPR201711-9500
A. Aderounmu
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引用次数: 0
FREQUENCY OF CHOLELITHIASIS - RELATED COMPLICATIONS IN MALE GENDER ATTENDING SURGICAL DEPARTMENT AT KING KHALID GENERAL HOSPITAL, MAJMAAH, KSA 沙特马吉玛哈立德国王总医院外科男性患者胆石症相关并发症的发生率
Pub Date : 2017-11-01 DOI: 10.20959/WJPR201711-9538
F. Alqahtani
Introduction: Gallstone disease known as cholelithiasis is one of the most common Biliary Tract disorder. Cholelithiasis is common with the incidence ranging from 10% to 20% of the world population, 11% of the general population of the US. The burden of gallstone disease and its complications, such as cholecystitis, pancreatitis, and cholangitis, are major public health issues globally. Objectives: This study aimed at determining the frequency of cholelithiasis-related complications in males admitted to surgical department at King Khalid General Hospital and assessing outcomes of male patients presented with cholelithiasis-related complications following case-tailored management. Methodology: It was a Retrospective descriptive, facility-based study to estimate the frequency and evaluation of cholelithiasis-related complications in males hospitalised in surgical department at King Khalid General Hospital, Majmaah, Saudi Arabia, January 2014December 2016. Results: 83 males were enrolled in our study, with their age groups being ranged from 19 to 99 years (M = 45.55, SD = 16.34). 5 different Complications were reported in our sample of interest. the majority, around 44.6%, suffered from Biliary colic followed by Acute cholecystitis (30.1%), Choledocholithiasis (13.3%), Chronic cholecystitis (8.4%) and Acute pancreatitis (3.6%) respectively. Following their treatment course, patients’ outcomes were as follow: 74 patients have improved while 4 needed to be transferred to another healthcare facility, 4 were HAMA (Home Against Medical Advice) World Journal of Pharmaceutical Research SJIF Impact Factor 7.523 Volume 6, Issue 11, 1-8. Research Article ISSN 2277– 7105 Article Received on 25 July 2017, Revised on 15 August 2017, Accepted on 04 Sept. 2017 DOI: 10.20959/wjpr201711-9538
胆结石病又称胆石症,是最常见的胆道疾病之一。胆石症很常见,发病率占世界人口的10%至20%,占美国总人口的11%。胆结石疾病及其并发症的负担,如胆囊炎、胰腺炎和胆管炎,是全球主要的公共卫生问题。目的:本研究旨在确定哈立德国王总医院(King Khalid General Hospital)外科收治的男性患者胆石症相关并发症的发生率,并评估出现胆石症相关并发症的男性患者在个体化治疗后的预后。方法:这是一项回顾性描述性、基于医院的研究,旨在评估2014年1月至2016年12月在沙特阿拉伯Majmaah哈立德国王总医院外科住院的男性胆石症相关并发症的频率和评估。结果:83名男性入组,年龄19 ~ 99岁(M = 45.55, SD = 16.34)。在我们感兴趣的样本中报告了5种不同的并发症。以胆道绞痛为主,约44.6%,其次为急性胆囊炎(30.1%)、胆总管结石(13.3%)、慢性胆囊炎(8.4%)和急性胰腺炎(3.6%)。在他们的治疗过程中,患者的结果如下:74名患者得到改善,4名需要转移到另一家医疗机构,4名是HAMA(反对医疗建议的家庭)世界药物研究杂志SJIF影响因子7.523卷6,第11期,1-8。文章收稿于2017年7月25日,修订于2017年8月15日,收稿于2017年9月4日DOI: 10.20959/wjpr201711-9538
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引用次数: 0
IN- SITU NASAL GEL: MODERNISTIC ADVANCEMENT IN DRUG DELIVERY 原位鼻凝胶:给药技术的现代进步
Pub Date : 2017-11-01 DOI: 10.20959/WJPR201711-9512
Anil P. Palhal
In-situ gel is a novel dosage form for nasal delivery of various drugs. It is instilled into the nasal cavity as low viscosity solution and then forms gel after coming in contact with the nasal mucosa. It also prolongs the contact time between drug and absorptive sites in the nasal cavity. In-situ nasal gel has got importance due to various advantages like rapid drug absorption, rapid onset of action, to avoid first pass metabolism and the drugs which are not suitable by other routes are given by nasal route. This review article contains various factors that influence nasal drug absorption like molecular weight, chemical form, polymorphism, solubility, dissolution rate, lipophilicity, pH, viscosity and osmolarity. Further, this review gives incite for the preparation of in-situ nasal gel by various methods viz., suspension polymerization, polymerization by irradiation, chemically and physically cross linked hydrogels etc. Evaluation of gels for gelation temperature, gelation time, appearance, pH, drug content, in vitro permeation studies, mucoadhesive strength, viscosity and rheological studies are also discussed.
原位凝胶是一种新型的药物鼻腔给药剂型。它以低粘度溶液的形式注入鼻腔,与鼻黏膜接触后形成凝胶。它还延长了药物与鼻腔吸收部位的接触时间。原位鼻凝胶具有药物吸收快、起效快、避免首次过期代谢、其他途径不适宜的药物可经鼻给药等优点,因此受到重视。本文综述了影响鼻腔药物吸收的各种因素,如分子量、化学形态、多态性、溶解度、溶出速率、亲脂性、pH、粘度和渗透压等。并对原位鼻凝胶的制备方法进行了综述,包括悬浮聚合、辐照聚合、化学和物理交联水凝胶等。评价凝胶的凝胶温度,凝胶时间,外观,pH,药物含量,体外渗透研究,粘接强度,粘度和流变学研究也进行了讨论。
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引用次数: 4
SURFACTANT CHARACTERIZATION OF CRUDE SAPONIN EXTRACTS OF GUAIACUM OFFICINALE LEAF AND STEM 愈创木叶、茎粗皂苷提取物的表面活性剂表征
Pub Date : 2017-11-01 DOI: 10.20959/WJPR201711-9631
Jayesh A. Patil
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引用次数: 0
期刊
World journal of pharmaceutical research
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