Pub Date : 2017-11-01DOI: 10.20959/wjpr201711-9619
A. Sharma
Chronic wound (ie. Dushta vrana) is one of the very serious issues faced by the health care professionals around the world. Normally a healthy wound heals timely itself with minimum scar formation and damage to skin as compared to those infected or contaminated. So all efforts are made in to keep the wound healthy and clean in all stages of its healing. A wound is said to be chronic/non healing if it does not heal through normal set of stages and in predictable amount of time. A lot of treatments modalities have been developed by modern science for the management of wound, but either it leave harmful side effects behind or they leave a financial burden on the patients. In India a large part of population lies below poverty line and cannot afford such costly treatments. Keeping this in sense, Priyangvadi Taila could be a better option for treating Dushta vrana (chronic/non healing wound). A case report of 20 year – young boy, who presented with complaints of an open wound on the anterior aspect of his right leg associated with pain, discharge, slough, odour, edema, discoloration of the skin and with a history of six years has been discussed here.
{"title":"A CASE STUDY OF DUSHTA VRANA (CHRONIC WOUND) TREATED WITH PRIYANGVADI TAILA","authors":"A. Sharma","doi":"10.20959/wjpr201711-9619","DOIUrl":"https://doi.org/10.20959/wjpr201711-9619","url":null,"abstract":"Chronic wound (ie. Dushta vrana) is one of the very serious issues faced by the health care professionals around the world. Normally a healthy wound heals timely itself with minimum scar formation and damage to skin as compared to those infected or contaminated. So all efforts are made in to keep the wound healthy and clean in all stages of its healing. A wound is said to be chronic/non healing if it does not heal through normal set of stages and in predictable amount of time. A lot of treatments modalities have been developed by modern science for the management of wound, but either it leave harmful side effects behind or they leave a financial burden on the patients. In India a large part of population lies below poverty line and cannot afford such costly treatments. Keeping this in sense, Priyangvadi Taila could be a better option for treating Dushta vrana (chronic/non healing wound). A case report of 20 year – young boy, who presented with complaints of an open wound on the anterior aspect of his right leg associated with pain, discharge, slough, odour, edema, discoloration of the skin and with a history of six years has been discussed here.","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"61 1","pages":"903-907"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73771295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/wjpr201711-9624
S. S. Subramanian
Elderly population and their health care needs life expectancy. Musculoskeletal conditions such as low backache, osteoarthritis of knee joints are common clinical entities recorded among geriatric subjects. This research aims to analyse Pilates and physiotherapy treatment on a subject with lowback ache, early knee osteoarthritis and bilateral. Hamstring Tightness Materials & Methodology: This research where 65 year old subject was treated for bilateral hamstring tightness, lowback ache and osteoarthritis knee in Chennai during the period from March 2017 to April 2017. Specific Pilates and physiotherapy exercises with weekly twice frequency. Results: pre and post VAS (P<.05), Womac (P<.05) and Oswestry score (P<.001) were recorded and statistically analyzed. Conclusion: An improved knee and lowback functions of life as reflected among this study subject with specific Pilates and physiotherapy lessens dependency, increase dignity and self esteem, hence an enhanced quality of life of this geriatric subject was evidenced.
{"title":"PILATES AND PHYSIOTHERAPY ON HAMSTRING TIGHTNESS – AN EVIDENCE BASED CASE STUDY","authors":"S. S. Subramanian","doi":"10.20959/wjpr201711-9624","DOIUrl":"https://doi.org/10.20959/wjpr201711-9624","url":null,"abstract":"Elderly population and their health care needs life expectancy. Musculoskeletal conditions such as low backache, osteoarthritis of knee joints are common clinical entities recorded among geriatric subjects. This research aims to analyse Pilates and physiotherapy treatment on a subject with lowback ache, early knee osteoarthritis and bilateral. Hamstring Tightness Materials & Methodology: This research where 65 year old subject was treated for bilateral hamstring tightness, lowback ache and osteoarthritis knee in Chennai during the period from March 2017 to April 2017. Specific Pilates and physiotherapy exercises with weekly twice frequency. Results: pre and post VAS (P<.05), Womac (P<.05) and Oswestry score (P<.001) were recorded and statistically analyzed. Conclusion: An improved knee and lowback functions of life as reflected among this study subject with specific Pilates and physiotherapy lessens dependency, increase dignity and self esteem, hence an enhanced quality of life of this geriatric subject was evidenced.","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"33 1","pages":"923-930"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80940023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/WJPR201711-9473
Mirza Farhana Ishaque, Nabila Anwar Patrawala, Dr. D. R. Majumder
The microorganisms showed the unique potential in the production and accumulation of nano metals with different shapes and sizes by „bioleaching‟. The biological system – Aspergillus species a fungus, isolated from soil was capable of synthesizing nanoparticles such as lithium, lead, and copper using LiCl3 (0.025M), Pb(NO3)2 (0.0002M), and CuSO4(0.025M) as a precursor metal salt. The morphology and the size of the synthesized nano metals as per Scanning Electron Microscopy micrograph confirmed the formation of LiNPs with 85 nm – 100 nm size range, CuNPs with 80 nm – 86 nm in range and PbNPs with 70 nm – 95 nm in range and all three were almost spherical in shape. These nano Metals were further characterized by UV Visible Spectrophotometry, Xray differaction analysis, Fourier Transform Infrared analysis, Cyclic Voltammetry. The ability of these nanoparticles in the field of electronics for the use in batteries were also tested. This green synthesis at room temperature was the most ecofriendly way to produce nano metals.
{"title":"PHARMACEUTICALLY RELEVANT CuNP, PbNP AND LiNP FROM ASPERGILLUS SPECIES","authors":"Mirza Farhana Ishaque, Nabila Anwar Patrawala, Dr. D. R. Majumder","doi":"10.20959/WJPR201711-9473","DOIUrl":"https://doi.org/10.20959/WJPR201711-9473","url":null,"abstract":"The microorganisms showed the unique potential in the production and accumulation of nano metals with different shapes and sizes by „bioleaching‟. The biological system – Aspergillus species a fungus, isolated from soil was capable of synthesizing nanoparticles such as lithium, lead, and copper using LiCl3 (0.025M), Pb(NO3)2 (0.0002M), and CuSO4(0.025M) as a precursor metal salt. The morphology and the size of the synthesized nano metals as per Scanning Electron Microscopy micrograph confirmed the formation of LiNPs with 85 nm – 100 nm size range, CuNPs with 80 nm – 86 nm in range and PbNPs with 70 nm – 95 nm in range and all three were almost spherical in shape. These nano Metals were further characterized by UV Visible Spectrophotometry, Xray differaction analysis, Fourier Transform Infrared analysis, Cyclic Voltammetry. The ability of these nanoparticles in the field of electronics for the use in batteries were also tested. This green synthesis at room temperature was the most ecofriendly way to produce nano metals.","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"8 1","pages":"531-545"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91301745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/WJPR201711-9600
M. G. Moniveena
{"title":"REGULATION OF REVERSE DISTRIBUTION OF CONTROLLED SUBSTANCES IN UNITED STATES","authors":"M. G. Moniveena","doi":"10.20959/WJPR201711-9600","DOIUrl":"https://doi.org/10.20959/WJPR201711-9600","url":null,"abstract":"","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"85 1","pages":"321-330"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81108249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/WJPR201711-8739
V. Manoj
Diclofenac sodium containing micro sponge as active constituent (API) in different formulations by changing the proportions of drug (diclofenac sodium), polymer (ethyl cellulose), emulsifier (Poly vinyl alcohol) were obtained successfully using quasi-emulsion solvent diffusion method.The micro sponges formulations were prepared by quasi emulsion solvent diffusion method employing ethyl cellulose as a polymer. The compatibility of the drug with formulation components was established by Fourier Transform Infra-Red (FTIR) spectroscopy. The surface morphology, particle size, production yield, and drug entrapment efficiency of micro sponges were examined. Shape and surface morphology of the micro sponges were examined using scanning electron microscopy. Particle size of prepared micro sponges was observed in the range of 28.7 ± 1.02 to 23.9 ± 1.19 μm. Scanning electron microscopy revealed the porous, spherical nature of the micro sponges. SEM photographs revealed the spherical nature of the micro sponges in all variations; however, at higher ratios, drug crystals were observed on the micro sponge surface. Increase in the drug/polymer ratio (1:1 to 1:10) increased their yield (10.85 ± 1.60 to 41.03 ± 1.26), average particle size of all formulations ranges from 28.7 μm to 45.9 μm which is in increasing order due to the increase in the concentration of polymer but after certain concentration it was observed that as the ratio of drug to polymer was increased, the particle size decreased, the drug content of different formulations was found in the range 19.07 ± 2.21 to 33.09 ±2.27, the cumulative release of the formulations are in the range of 89.83% to 13.25%. World Journal of Pharmaceutical Research SJIF Impact Factor 7.523 Volume 6, Issue 11, 417-429. Research Article ISSN 2277– 7105 Article Received on 25 July 2017, Revised on 15 August 2017, Accepted on 04 Sept. 2017 DOI: 10.20959/wjpr201711-8739
{"title":"FORMULATION AND EVALUATION OF MICROSPONGES OF DICLOFENAC SODIUM","authors":"V. Manoj","doi":"10.20959/WJPR201711-8739","DOIUrl":"https://doi.org/10.20959/WJPR201711-8739","url":null,"abstract":"Diclofenac sodium containing micro sponge as active constituent (API) in different formulations by changing the proportions of drug (diclofenac sodium), polymer (ethyl cellulose), emulsifier (Poly vinyl alcohol) were obtained successfully using quasi-emulsion solvent diffusion method.The micro sponges formulations were prepared by quasi emulsion solvent diffusion method employing ethyl cellulose as a polymer. The compatibility of the drug with formulation components was established by Fourier Transform Infra-Red (FTIR) spectroscopy. The surface morphology, particle size, production yield, and drug entrapment efficiency of micro sponges were examined. Shape and surface morphology of the micro sponges were examined using scanning electron microscopy. Particle size of prepared micro sponges was observed in the range of 28.7 ± 1.02 to 23.9 ± 1.19 μm. Scanning electron microscopy revealed the porous, spherical nature of the micro sponges. SEM photographs revealed the spherical nature of the micro sponges in all variations; however, at higher ratios, drug crystals were observed on the micro sponge surface. Increase in the drug/polymer ratio (1:1 to 1:10) increased their yield (10.85 ± 1.60 to 41.03 ± 1.26), average particle size of all formulations ranges from 28.7 μm to 45.9 μm which is in increasing order due to the increase in the concentration of polymer but after certain concentration it was observed that as the ratio of drug to polymer was increased, the particle size decreased, the drug content of different formulations was found in the range 19.07 ± 2.21 to 33.09 ±2.27, the cumulative release of the formulations are in the range of 89.83% to 13.25%. World Journal of Pharmaceutical Research SJIF Impact Factor 7.523 Volume 6, Issue 11, 417-429. Research Article ISSN 2277– 7105 Article Received on 25 July 2017, Revised on 15 August 2017, Accepted on 04 Sept. 2017 DOI: 10.20959/wjpr201711-8739","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"42 1","pages":"417-429"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81390220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/WJPR201711-9500
A. Aderounmu
{"title":"AN EXPERIMENTAL STUDY OF THE TOXICITY EFFECTS OF CALOTROPIS PROCERA (AITON) ASCLEPIADACEAE IN SPRAGUE-DAWLEY RATS","authors":"A. Aderounmu","doi":"10.20959/WJPR201711-9500","DOIUrl":"https://doi.org/10.20959/WJPR201711-9500","url":null,"abstract":"","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"81 1","pages":"42-55"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83987341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/WJPR201711-9538
F. Alqahtani
Introduction: Gallstone disease known as cholelithiasis is one of the most common Biliary Tract disorder. Cholelithiasis is common with the incidence ranging from 10% to 20% of the world population, 11% of the general population of the US. The burden of gallstone disease and its complications, such as cholecystitis, pancreatitis, and cholangitis, are major public health issues globally. Objectives: This study aimed at determining the frequency of cholelithiasis-related complications in males admitted to surgical department at King Khalid General Hospital and assessing outcomes of male patients presented with cholelithiasis-related complications following case-tailored management. Methodology: It was a Retrospective descriptive, facility-based study to estimate the frequency and evaluation of cholelithiasis-related complications in males hospitalised in surgical department at King Khalid General Hospital, Majmaah, Saudi Arabia, January 2014December 2016. Results: 83 males were enrolled in our study, with their age groups being ranged from 19 to 99 years (M = 45.55, SD = 16.34). 5 different Complications were reported in our sample of interest. the majority, around 44.6%, suffered from Biliary colic followed by Acute cholecystitis (30.1%), Choledocholithiasis (13.3%), Chronic cholecystitis (8.4%) and Acute pancreatitis (3.6%) respectively. Following their treatment course, patients’ outcomes were as follow: 74 patients have improved while 4 needed to be transferred to another healthcare facility, 4 were HAMA (Home Against Medical Advice) World Journal of Pharmaceutical Research SJIF Impact Factor 7.523 Volume 6, Issue 11, 1-8. Research Article ISSN 2277– 7105 Article Received on 25 July 2017, Revised on 15 August 2017, Accepted on 04 Sept. 2017 DOI: 10.20959/wjpr201711-9538
{"title":"FREQUENCY OF CHOLELITHIASIS - RELATED COMPLICATIONS IN MALE GENDER ATTENDING SURGICAL DEPARTMENT AT KING KHALID GENERAL HOSPITAL, MAJMAAH, KSA","authors":"F. Alqahtani","doi":"10.20959/WJPR201711-9538","DOIUrl":"https://doi.org/10.20959/WJPR201711-9538","url":null,"abstract":"Introduction: Gallstone disease known as cholelithiasis is one of the most common Biliary Tract disorder. Cholelithiasis is common with the incidence ranging from 10% to 20% of the world population, 11% of the general population of the US. The burden of gallstone disease and its complications, such as cholecystitis, pancreatitis, and cholangitis, are major public health issues globally. Objectives: This study aimed at determining the frequency of cholelithiasis-related complications in males admitted to surgical department at King Khalid General Hospital and assessing outcomes of male patients presented with cholelithiasis-related complications following case-tailored management. Methodology: It was a Retrospective descriptive, facility-based study to estimate the frequency and evaluation of cholelithiasis-related complications in males hospitalised in surgical department at King Khalid General Hospital, Majmaah, Saudi Arabia, January 2014December 2016. Results: 83 males were enrolled in our study, with their age groups being ranged from 19 to 99 years (M = 45.55, SD = 16.34). 5 different Complications were reported in our sample of interest. the majority, around 44.6%, suffered from Biliary colic followed by Acute cholecystitis (30.1%), Choledocholithiasis (13.3%), Chronic cholecystitis (8.4%) and Acute pancreatitis (3.6%) respectively. Following their treatment course, patients’ outcomes were as follow: 74 patients have improved while 4 needed to be transferred to another healthcare facility, 4 were HAMA (Home Against Medical Advice) World Journal of Pharmaceutical Research SJIF Impact Factor 7.523 Volume 6, Issue 11, 1-8. Research Article ISSN 2277– 7105 Article Received on 25 July 2017, Revised on 15 August 2017, Accepted on 04 Sept. 2017 DOI: 10.20959/wjpr201711-9538","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"35 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79784529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/WJPR201711-9512
Anil P. Palhal
In-situ gel is a novel dosage form for nasal delivery of various drugs. It is instilled into the nasal cavity as low viscosity solution and then forms gel after coming in contact with the nasal mucosa. It also prolongs the contact time between drug and absorptive sites in the nasal cavity. In-situ nasal gel has got importance due to various advantages like rapid drug absorption, rapid onset of action, to avoid first pass metabolism and the drugs which are not suitable by other routes are given by nasal route. This review article contains various factors that influence nasal drug absorption like molecular weight, chemical form, polymorphism, solubility, dissolution rate, lipophilicity, pH, viscosity and osmolarity. Further, this review gives incite for the preparation of in-situ nasal gel by various methods viz., suspension polymerization, polymerization by irradiation, chemically and physically cross linked hydrogels etc. Evaluation of gels for gelation temperature, gelation time, appearance, pH, drug content, in vitro permeation studies, mucoadhesive strength, viscosity and rheological studies are also discussed.
{"title":"IN- SITU NASAL GEL: MODERNISTIC ADVANCEMENT IN DRUG DELIVERY","authors":"Anil P. Palhal","doi":"10.20959/WJPR201711-9512","DOIUrl":"https://doi.org/10.20959/WJPR201711-9512","url":null,"abstract":"In-situ gel is a novel dosage form for nasal delivery of various drugs. It is instilled into the nasal cavity as low viscosity solution and then forms gel after coming in contact with the nasal mucosa. It also prolongs the contact time between drug and absorptive sites in the nasal cavity. In-situ nasal gel has got importance due to various advantages like rapid drug absorption, rapid onset of action, to avoid first pass metabolism and the drugs which are not suitable by other routes are given by nasal route. This review article contains various factors that influence nasal drug absorption like molecular weight, chemical form, polymorphism, solubility, dissolution rate, lipophilicity, pH, viscosity and osmolarity. Further, this review gives incite for the preparation of in-situ nasal gel by various methods viz., suspension polymerization, polymerization by irradiation, chemically and physically cross linked hydrogels etc. Evaluation of gels for gelation temperature, gelation time, appearance, pH, drug content, in vitro permeation studies, mucoadhesive strength, viscosity and rheological studies are also discussed.","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"158 1","pages":"566-577"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73228712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/WJPR201711-9631
Jayesh A. Patil
{"title":"SURFACTANT CHARACTERIZATION OF CRUDE SAPONIN EXTRACTS OF GUAIACUM OFFICINALE LEAF AND STEM","authors":"Jayesh A. Patil","doi":"10.20959/WJPR201711-9631","DOIUrl":"https://doi.org/10.20959/WJPR201711-9631","url":null,"abstract":"","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"328 1","pages":"974-981"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75472218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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