Pub Date : 2017-11-01DOI: 10.20959/WJPR201711-9560
B. Mori
ABSTARCT Ayurveda is one of the oldest system of medicine in the world, its antiquity going back to the Vedas. It adapts a unique holistic approach to the antire science. Aachaaryas have mentioned various herbal formulations in Samhitas. Also Mentions methods to quality control and to standardization those formulations. And also it has been developed different techniques to evaluate the quality of medicines by modern science. So there is a current need of analyze Ayurvedic products also according to modern scientific. So this study is prove to authenticity and quality of the drugs. Hence the present study was carried out to pharmacognostical parameters like organoleptic and microscopic, Phrmaco chemical parameters like loss on drying, ph, Ash value, Water soluble extract, Alcohol soluble extract and sugar lavel, HPTLC Study of Modified Musta triphaladi avaleha. It has been using in to treatment of Thalassemia major as a adjuvant therapy.
{"title":"PHARMACOGNOSTICAL AND PHYSICOCHAMICAL ANALYSIS OF MODIFIED MUSTA TRIPHALADI AVALEHA–A POLY-HERBAL FORMULATION USED IN THALASSEMIA MAJOR","authors":"B. Mori","doi":"10.20959/WJPR201711-9560","DOIUrl":"https://doi.org/10.20959/WJPR201711-9560","url":null,"abstract":"ABSTARCT Ayurveda is one of the oldest system of medicine in the world, its antiquity going back to the Vedas. It adapts a unique holistic approach to the antire science. Aachaaryas have mentioned various herbal formulations in Samhitas. Also Mentions methods to quality control and to standardization those formulations. And also it has been developed different techniques to evaluate the quality of medicines by modern science. So there is a current need of analyze Ayurvedic products also according to modern scientific. So this study is prove to authenticity and quality of the drugs. Hence the present study was carried out to pharmacognostical parameters like organoleptic and microscopic, Phrmaco chemical parameters like loss on drying, ph, Ash value, Water soluble extract, Alcohol soluble extract and sugar lavel, HPTLC Study of Modified Musta triphaladi avaleha. It has been using in to treatment of Thalassemia major as a adjuvant therapy.","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86021174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/wjpr201711-9537
M. Vasanth
The aim of the present study was to determine the in vitro antimicrobial activity of various solvent extracts of Muntingia calabura L. leaves against selected microorganism. It was observed that Ethyl acetate crude extract of 30 μL showed maximum inhibitory activity against Escherichia coli. Similarly, the minimum inhibitory activity showed in aqueous crude extract about 10 μL concentration.
{"title":"ANTIMICROBIAL ACTIVITY OF MUTINGIA CALABURA L","authors":"M. Vasanth","doi":"10.20959/wjpr201711-9537","DOIUrl":"https://doi.org/10.20959/wjpr201711-9537","url":null,"abstract":"The aim of the present study was to determine the in vitro antimicrobial activity of various solvent extracts of Muntingia calabura L. leaves against selected microorganism. It was observed that Ethyl acetate crude extract of 30 μL showed maximum inhibitory activity against Escherichia coli. Similarly, the minimum inhibitory activity showed in aqueous crude extract about 10 μL concentration.","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84671390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/WJPR201711-9553
K. Soni
Tamaka Shwaasa is basically a disorder of Praanavaha Srootasas while other Srootasas are also vitiated. The parallel disease entity in contemporary medical science to this disorder is Bronchial Asthma. Bronchial Asthma is a chronic inflammatory condition of the lung airways resulting in episodic airflow obstruction. This disease is more predominant in children and aged population. In Charaka Samhita, the group of ten drugs is mentioned for the management of the Shwasa Roga named as Shwasahara Dashemani. Palatability is a main issue in treatment of children so keep it mind the avaleha form is prepared which is very easily palatable in children. Till date no published data is available regarding evaluation the effect of Shwasahara Dashemani Avaleha. Methods: Final product was subjected to Phrmacognostical and physico-chemical analysis such as microscopic study, loss on drying, ash value, pH etc. Results: Phrmacognostical study showed the presence of contents such as; annular vessels of Shati, simple trichome of Tulsi, rossels crystal of Jivanti etc. Preliminary physico-chemical analysis showed that the loss on drying value was found to be 25.66%, pH 6.5, Ash value-o.88%, Water soluble extract 76.01% etc. High Performance Thin Layer Chromatography (HPTLC) showed 6 and 3 spots at 254nm and 366nm respectively. Conclusion: The present work was carried out to standardize the finished product Shwasahara dashemani Churna in terms of its identity, World Journal of Pharmaceutical Research SJIF Impact Factor 7.523 Volume 6, Issue 11, 740-747. Research Article ISSN 2277– 7105 Article Received on 27 July 2017, Revised on 16 August 2017, Accepted on 05 Sept. 2017 DOI: 10.20959/wjpr201711-9553 *Corresponding Author Dr. Kuldeep Kumar Soni PG Scholar, 2 nd yr, Department of Kaumarbhritya. I.P.G.T. and R.A, GAU.
{"title":"PHARMACOGNOSTICAL AND PHARMACEUTICAL ANALYSIS OF SHAWASAHARA DASHEMANI AVALEHA","authors":"K. Soni","doi":"10.20959/WJPR201711-9553","DOIUrl":"https://doi.org/10.20959/WJPR201711-9553","url":null,"abstract":"Tamaka Shwaasa is basically a disorder of Praanavaha Srootasas while other Srootasas are also vitiated. The parallel disease entity in contemporary medical science to this disorder is Bronchial Asthma. Bronchial Asthma is a chronic inflammatory condition of the lung airways resulting in episodic airflow obstruction. This disease is more predominant in children and aged population. In Charaka Samhita, the group of ten drugs is mentioned for the management of the Shwasa Roga named as Shwasahara Dashemani. Palatability is a main issue in treatment of children so keep it mind the avaleha form is prepared which is very easily palatable in children. Till date no published data is available regarding evaluation the effect of Shwasahara Dashemani Avaleha. Methods: Final product was subjected to Phrmacognostical and physico-chemical analysis such as microscopic study, loss on drying, ash value, pH etc. Results: Phrmacognostical study showed the presence of contents such as; annular vessels of Shati, simple trichome of Tulsi, rossels crystal of Jivanti etc. Preliminary physico-chemical analysis showed that the loss on drying value was found to be 25.66%, pH 6.5, Ash value-o.88%, Water soluble extract 76.01% etc. High Performance Thin Layer Chromatography (HPTLC) showed 6 and 3 spots at 254nm and 366nm respectively. Conclusion: The present work was carried out to standardize the finished product Shwasahara dashemani Churna in terms of its identity, World Journal of Pharmaceutical Research SJIF Impact Factor 7.523 Volume 6, Issue 11, 740-747. Research Article ISSN 2277– 7105 Article Received on 27 July 2017, Revised on 16 August 2017, Accepted on 05 Sept. 2017 DOI: 10.20959/wjpr201711-9553 *Corresponding Author Dr. Kuldeep Kumar Soni PG Scholar, 2 nd yr, Department of Kaumarbhritya. I.P.G.T. and R.A, GAU.","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84810601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/WJPR201711-9602
Sukardiman Sukardiman
The optimal growth of plant can be influenced by various factors, including the growing place. Because it could influenced the metabolites biosynthesis. This aimed study is to comparison the metabolite level, such as sinensetin of O. stamineus leaves from three regions in Indonesia (Tawangmangu, Batu and Trenggalek). The determination of sinensetin using TLC-densitometry with silica gel as solid phase and Chloroform-ethylaceate (60:40) as solvent system. The result showed the percentage of sinensetin in samples Tawangmangu, Batu and Trenggalek region were 0.04 ± 0.01; 0.07± 0.01 and 0.14 ± 0.01 respectively. It can be concluded that the best planting area that can produce fertile Orthosiphon stamineus with the highest content of sinensetin was in Trenggalek region. KEYWORD: Orthsiphon stamineus, Sinensetin, planting, regions INTRODUCTIONS Orthosiphon stamineus Benth of Lamiaceae family is a medicinal plant that widely grown in tropical areas. The plant can be identified by its white or purple colored flowers that resembles cat whiskers. It is also commonly referred as "Kumis Kucing" which means cat whiskers. The herb is popularly known as Java tea and is used widely in the form of herbal tea in Asia. [1] The leaves of this plant are used in traditional medicine as a diuretics, rheumatisme, urinary tract infection, kronic and acute kidney infection and billiary lithiasis. [2] There are many World Journal of Pharmaceutical Research SJIF Impact Factor 7.523 Volume 6, Issue 11, 96-102. Research Article ISSN 2277–7105 *Corresponding Author Dr. Sukardiman Departement of Pharmacognosy and Phytochemistry, Faculty of Pharmacy Universitas Airlangga, Surabaya, Indonesia. Article Received on 29 July 2017, Revised on 18 August 2017, Accepted on 07 Sep 2017 DOI: 10.20959/wjpr201711-9602
{"title":"COMPARATIVE STUDY OF SINENSETIN COMPOUND IN THE LEAVES OF ORTHOSIPHON STAMINEUS BENTH. FROM DIFFERENT REGIONS OF INDONESIA","authors":"Sukardiman Sukardiman","doi":"10.20959/WJPR201711-9602","DOIUrl":"https://doi.org/10.20959/WJPR201711-9602","url":null,"abstract":"The optimal growth of plant can be influenced by various factors, including the growing place. Because it could influenced the metabolites biosynthesis. This aimed study is to comparison the metabolite level, such as sinensetin of O. stamineus leaves from three regions in Indonesia (Tawangmangu, Batu and Trenggalek). The determination of sinensetin using TLC-densitometry with silica gel as solid phase and Chloroform-ethylaceate (60:40) as solvent system. The result showed the percentage of sinensetin in samples Tawangmangu, Batu and Trenggalek region were 0.04 ± 0.01; 0.07± 0.01 and 0.14 ± 0.01 respectively. It can be concluded that the best planting area that can produce fertile Orthosiphon stamineus with the highest content of sinensetin was in Trenggalek region. KEYWORD: Orthsiphon stamineus, Sinensetin, planting, regions INTRODUCTIONS Orthosiphon stamineus Benth of Lamiaceae family is a medicinal plant that widely grown in tropical areas. The plant can be identified by its white or purple colored flowers that resembles cat whiskers. It is also commonly referred as \"Kumis Kucing\" which means cat whiskers. The herb is popularly known as Java tea and is used widely in the form of herbal tea in Asia. [1] The leaves of this plant are used in traditional medicine as a diuretics, rheumatisme, urinary tract infection, kronic and acute kidney infection and billiary lithiasis. [2] There are many World Journal of Pharmaceutical Research SJIF Impact Factor 7.523 Volume 6, Issue 11, 96-102. Research Article ISSN 2277–7105 *Corresponding Author Dr. Sukardiman Departement of Pharmacognosy and Phytochemistry, Faculty of Pharmacy Universitas Airlangga, Surabaya, Indonesia. Article Received on 29 July 2017, Revised on 18 August 2017, Accepted on 07 Sep 2017 DOI: 10.20959/wjpr201711-9602","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84553303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/WJPR201711-9251
Y. S. Kotawala
According to Ayurveda Bhaishajya kaal (time of drug administration) is an important principle to be considered while treating a disease. In Ayurveda many Acharya has given different Bhaishajya kaal according to the doshas, diseases, different conditions of the body and different preparations (swaras, kalka, kwath). According to the modern medicine, it is called drug chronotherapy. It advocates syncing your medication regimen with your circadian rhythm. If daily pills at the right time can help you maximise their benefits and avoid dangerous interactions.while treating a disease success can be achieved only when there is proper combination of desha(region), kaala(time), pramana (dosage), satmya (wholesomeness), asatmya (unwholesomeness), pathya (useful) & apathy (harmful). Among these seven most important factors, kaala acquires second position, which reflects the importance of kaala in chikitsa. The above paper focus on Bhaishajya kaal according to Ayurveda and modern medicine.
{"title":"AUSHADH SEVAN KAAL IN AYURVEDA AND MODERN SCIENCE","authors":"Y. S. Kotawala","doi":"10.20959/WJPR201711-9251","DOIUrl":"https://doi.org/10.20959/WJPR201711-9251","url":null,"abstract":"According to Ayurveda Bhaishajya kaal (time of drug administration) is an important principle to be considered while treating a disease. In Ayurveda many Acharya has given different Bhaishajya kaal according to the doshas, diseases, different conditions of the body and different preparations (swaras, kalka, kwath). According to the modern medicine, it is called drug chronotherapy. It advocates syncing your medication regimen with your circadian rhythm. If daily pills at the right time can help you maximise their benefits and avoid dangerous interactions.while treating a disease success can be achieved only when there is proper combination of desha(region), kaala(time), pramana (dosage), satmya (wholesomeness), asatmya (unwholesomeness), pathya (useful) & apathy (harmful). Among these seven most important factors, kaala acquires second position, which reflects the importance of kaala in chikitsa. The above paper focus on Bhaishajya kaal according to Ayurveda and modern medicine.","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81776623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/wjpr201711-9556
Sauryya Bhattacharyya
Silver nanoparticles, prepared from leaf of Justicia adhatoda and Nyctanthes arbor-tristis were tested for their antioxidant and antimicrobial properties. Among the five standard antioxidant assay protocols (viz. ABTS radical decolorization assay, DPPH radical decolorization assay, assay for total phenolis content, FRAP assay and hydroxyl radical scavenging assay) applied in the present study, nanoparticles showed comparable antioxidant activities with the aqueous leaf extracts. A probable chelation of the less polar biomolecules with Ag + ion during nanoparticle formation was also indicated. Nanoparticle formation also improved the bacteriostatic properties in terms of zone of inhibition against all the five bacteria (viz. Escherichia coli, Klebsiella aerogens, Staphylococcus aureus, Salmonella typhi and Bacillus cereus) tested in the study. Improvement in bacteriostatic activities of the nanoparticles clearly indicated potential use of the nanoparticles against food borne bacteria for application in favor of humans.
{"title":"BACTERIOSTATIC ACTIVITIES OF ANTIOXIDANT SILVER NANOPARTICLES PREPARED FROM LEAVES OF JUSTICIA ADHATODA AND NYCTANTHES ARBOR-TRISTIS","authors":"Sauryya Bhattacharyya","doi":"10.20959/wjpr201711-9556","DOIUrl":"https://doi.org/10.20959/wjpr201711-9556","url":null,"abstract":"Silver nanoparticles, prepared from leaf of Justicia adhatoda and Nyctanthes arbor-tristis were tested for their antioxidant and antimicrobial properties. Among the five standard antioxidant assay protocols (viz. ABTS radical decolorization assay, DPPH radical decolorization assay, assay for total phenolis content, FRAP assay and hydroxyl radical scavenging assay) applied in the present study, nanoparticles showed comparable antioxidant activities with the aqueous leaf extracts. A probable chelation of the less polar biomolecules with Ag + ion during nanoparticle formation was also indicated. Nanoparticle formation also improved the bacteriostatic properties in terms of zone of inhibition against all the five bacteria (viz. Escherichia coli, Klebsiella aerogens, Staphylococcus aureus, Salmonella typhi and Bacillus cereus) tested in the study. Improvement in bacteriostatic activities of the nanoparticles clearly indicated potential use of the nanoparticles against food borne bacteria for application in favor of humans.","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81577252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/WJPR201711-9576
A. Alalyani
Objectives: To estimate the prevalence of non-adherence to medication among and to explore the different reasons for drug non adherence among patient in mental health hospital in Taif city. Subjects and methods: It is a Cross-sectional descriptive study. The study included 255 patients who were following in Mental Health Hospital clinic. The total number was 255 patients, 233 patients were included in the study and 22 were excluded from the study according to eligibility criteria. The tool of the study was a self-administered questionnaire, which consists of three Parts: Demographic data, psychiatric diagnosis and reasons of not take the treatment. Result: Incidence of non-adherence was high (84.1%). The factors that increased the likelihood of non-adherence were absence of job, familial support and health education about medication use in addition to occurrence of side effects. Conclusion: The frequency of non-adherence is relatively high among the patients with psychiatric disorders in Taif city. Prevention strategies should focus on enhancing socioeconomic status (education and employment) and effective health education of patients to enable them to deal with adverse drug effects. KEYWORD: prevalence, Non Adherence, Mental Health, Taif city. INTRODUCTION Background: Adherence is defined as ―the extent to which the patient’s behavior (in terms of taking medications, following diets, or executing other lifestyle changes) matches medical World Journal of Pharmaceutical Research SJIF Impact Factor 7.523 Volume 6, Issue 11, 56-71. Research Article ISSN 2277–7105 *Corresponding Author Abdullah Saad Abdullah Alalyani Medical Intern, MBBS, College of Medicine, Taif University Saudi Arabia, Taif. Article Received on 25 July 2017, Revised on 15 August 2017, Accepted on 05 Sept. 2017 DOI: 10.20959/wjpr201711-9576
目的:了解台福市精神卫生医院患者药物不依从的发生率，并探讨药物不依从的不同原因。研究对象与方法:本研究为横断面描述性研究。该研究包括255名在精神健康医院诊所随访的患者。总人数为255例，233例纳入研究，22例根据入选标准被排除。本研究的工具是一份自我管理的问卷，问卷由三部分组成:人口统计资料、精神诊断和不接受治疗的原因。结果:不依从性发生率高(84.1%)。增加不遵守可能性的因素除了副作用的发生外，还有缺乏工作、家庭支持和关于药物使用的健康教育。结论:塔伊夫市精神障碍患者服药不依从率较高。预防战略应侧重于提高患者的社会经济地位(教育和就业)和有效的健康教育，使他们能够应对药物的不良影响。关键词:患病率;不依从;心理健康;背景:依从性被定义为患者的行为(在服用药物、遵循饮食或执行其他生活方式改变方面)与医学相匹配的程度。《世界药物研究杂志》SJIF影响因子7.523卷6，第11期，56-71。研究论文ISSN 2277-7105 *通讯作者Abdullah Saad Abdullah Alalyani医学实习生，MBBS，沙特阿拉伯塔伊夫大学医学院。文章收于2017年7月25日，修订于2017年8月15日，收于2017年9月5日DOI: 10.20959/wjpr201711-9576
{"title":"PREVALENCE AND RISK FACTORS OF NON-ADHERENCE IN PSYCHIATRIC PATIENTS IN TAIF, SAUDI ARABIA","authors":"A. Alalyani","doi":"10.20959/WJPR201711-9576","DOIUrl":"https://doi.org/10.20959/WJPR201711-9576","url":null,"abstract":"Objectives: To estimate the prevalence of non-adherence to medication among and to explore the different reasons for drug non adherence among patient in mental health hospital in Taif city. Subjects and methods: It is a Cross-sectional descriptive study. The study included 255 patients who were following in Mental Health Hospital clinic. The total number was 255 patients, 233 patients were included in the study and 22 were excluded from the study according to eligibility criteria. The tool of the study was a self-administered questionnaire, which consists of three Parts: Demographic data, psychiatric diagnosis and reasons of not take the treatment. Result: Incidence of non-adherence was high (84.1%). The factors that increased the likelihood of non-adherence were absence of job, familial support and health education about medication use in addition to occurrence of side effects. Conclusion: The frequency of non-adherence is relatively high among the patients with psychiatric disorders in Taif city. Prevention strategies should focus on enhancing socioeconomic status (education and employment) and effective health education of patients to enable them to deal with adverse drug effects. KEYWORD: prevalence, Non Adherence, Mental Health, Taif city. INTRODUCTION Background: Adherence is defined as ―the extent to which the patient’s behavior (in terms of taking medications, following diets, or executing other lifestyle changes) matches medical World Journal of Pharmaceutical Research SJIF Impact Factor 7.523 Volume 6, Issue 11, 56-71. Research Article ISSN 2277–7105 *Corresponding Author Abdullah Saad Abdullah Alalyani Medical Intern, MBBS, College of Medicine, Taif University Saudi Arabia, Taif. Article Received on 25 July 2017, Revised on 15 August 2017, Accepted on 05 Sept. 2017 DOI: 10.20959/wjpr201711-9576","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85677450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/wjpr201711-9635
A. Reddy, N. Kathale
The present paper describes the synthesis and anti-inflammatory activity of some new hydrazide-hydrazone derivatives (4a-n) from commercially available vanillin as starting material in three synthetic steps. Step 1 involves the iodination of vanillin in presence of benzyltrimethylammonium dichloroiodate as iodinating reagent; Step 2 involves the coupling of 2-(bromomethyl)-5-nitrofuran with 5iodovanillin in presence of room temperature ionic liquid such as [bmim] [PF6]; Step 3 involves condensation of 4-((5-nitrofuran-2-yl) methoxy)-3-iodo-5-methoxybenzaldehyde with various benzohydrazides under solvent free conditions resulting in the formation of final compounds, hydrazide-hydrazone derivatives. The structures of these derivatives were determined by 1 H NMR, IR, mass spectroscopic techniques and evaluated for anti-inflammatory activity (carrageenan induced inflammatory rat model). Compounds with substitution R = 4-F, 4-OH, 4-SO2Me, 2,4-difluoro and R = 3,4,5-trimethoxy in the main scaffold displayed significant anti-inflammatory activity.
{"title":"SYNTHESIS, CHARACTERIZATION AND ANTI-INFLAMMATORY ACTIVITY OF HYDRAZONES BEARING 5-NITRO-FURAN MOIETY AND 5-IODO-VANILLIN HYBRID","authors":"A. Reddy, N. Kathale","doi":"10.20959/wjpr201711-9635","DOIUrl":"https://doi.org/10.20959/wjpr201711-9635","url":null,"abstract":"The present paper describes the synthesis and anti-inflammatory activity of some new hydrazide-hydrazone derivatives (4a-n) from commercially available vanillin as starting material in three synthetic steps. Step 1 involves the iodination of vanillin in presence of benzyltrimethylammonium dichloroiodate as iodinating reagent; Step 2 involves the coupling of 2-(bromomethyl)-5-nitrofuran with 5iodovanillin in presence of room temperature ionic liquid such as [bmim] [PF6]; Step 3 involves condensation of 4-((5-nitrofuran-2-yl) methoxy)-3-iodo-5-methoxybenzaldehyde with various benzohydrazides under solvent free conditions resulting in the formation of final compounds, hydrazide-hydrazone derivatives. The structures of these derivatives were determined by 1 H NMR, IR, mass spectroscopic techniques and evaluated for anti-inflammatory activity (carrageenan induced inflammatory rat model). Compounds with substitution R = 4-F, 4-OH, 4-SO2Me, 2,4-difluoro and R = 3,4,5-trimethoxy in the main scaffold displayed significant anti-inflammatory activity.","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89859684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/wjpr201711-9626
J. Shaji
Gold nanoparticles (AuNPs) have been used as a preferred therapeutic agent to treat a wide variety of diseases mainly cancers. Although the use of gold has been largely suspended by newer drugs, gold nanoparticles are still being used effectively in laboratory based clinical diagnostic methods concurrently showing great effectiveness in vivo as a theronostic agent. Also recent advances in nanocarriers for therapeutic use with Au-containing drugs is improving the beneficial actions and reducing toxic properties of these agents. For these reasons, gold nanoparticles are well placed to enter mainstream clinical practice in the near future. The present review summarizes the chemistry, Therapeutics, route of administration, synthesis methods, pharmacokinetics, bio-distribution, and toxicity of bulk gold nanoparticles based on clinical observation and experiments in which gold nanoparticles were used to treat patients with various diseases. The beneficial attributes of gold nanoparticles, such as their ease of synthesis, biocompatibility, functionalization and shape control are also highlighted demonstrating why gold nanoparticles are an attractive target for further development and optimization. The biomedical applications and current discoveries in the field of gold nanoparticles were also highlighted via patent and clinical trial overview.
{"title":"EVOLUTION OF GOLD NANOPARTICLES: PHARMACOKINETICS, TOXICOLOGY AND PATENT OVERVIEW.","authors":"J. Shaji","doi":"10.20959/wjpr201711-9626","DOIUrl":"https://doi.org/10.20959/wjpr201711-9626","url":null,"abstract":"Gold nanoparticles (AuNPs) have been used as a preferred therapeutic agent to treat a wide variety of diseases mainly cancers. Although the use of gold has been largely suspended by newer drugs, gold nanoparticles are still being used effectively in laboratory based clinical diagnostic methods concurrently showing great effectiveness in vivo as a theronostic agent. Also recent advances in nanocarriers for therapeutic use with Au-containing drugs is improving the beneficial actions and reducing toxic properties of these agents. For these reasons, gold nanoparticles are well placed to enter mainstream clinical practice in the near future. The present review summarizes the chemistry, Therapeutics, route of administration, synthesis methods, pharmacokinetics, bio-distribution, and toxicity of bulk gold nanoparticles based on clinical observation and experiments in which gold nanoparticles were used to treat patients with various diseases. The beneficial attributes of gold nanoparticles, such as their ease of synthesis, biocompatibility, functionalization and shape control are also highlighted demonstrating why gold nanoparticles are an attractive target for further development and optimization. The biomedical applications and current discoveries in the field of gold nanoparticles were also highlighted via patent and clinical trial overview.","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74539309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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