Pub Date : 2017-11-01DOI: 10.20959/WJPR201711-9592
Dip S. Kondhia
{"title":"REVIEW ON NANOCRYSTAL","authors":"Dip S. Kondhia","doi":"10.20959/WJPR201711-9592","DOIUrl":"https://doi.org/10.20959/WJPR201711-9592","url":null,"abstract":"","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"6 1","pages":"293-311"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75233610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/WJPR201711-9415
D. Bhatt
There is no known cure for multiple sclerosis. Treatments attempt to improve function after an attack and prevent new attacks. Medications used to treat MS, while modestly effective, can have side effects and be poorly tolerated Multiple sclerosis usually starts with an acute episode of neurological disturbance, termed a 'clinically isolated syndrome', followed by an illness phase punctuated by relapses and remissions which may transition after 10 years to a phase of progressive accumulation of disability without relapses. Fifteen to 20% of patients will have a progressive course from the onset. There is significant interpatient variability in prognosis. The main diagnostic criteria are clinical, supported by investigations including magnetic resonance imaging and lumbar puncture and evoked potentials. First line disease modifying agents for relapsing remitting multiple sclerosis include interferon-ß and glatiramer. First line treatment for relapses is usually intravenous methylprednisolone for 3 days. Troublesome symptoms may include spasticity, parasthesias, tremor, erectile dysfunction, depression and anxiety, fatigue and pain. After excluding differential diagnoses, symptomatic management includes pharmacological agents, allied health consultation and continence strategies. Although pregnancy reduces disease activity, there is a higher risk of relapse in the postpartum period.
{"title":"BRIEF REVIEW ON MULTIPLE SCLEROSIS","authors":"D. Bhatt","doi":"10.20959/WJPR201711-9415","DOIUrl":"https://doi.org/10.20959/WJPR201711-9415","url":null,"abstract":"There is no known cure for multiple sclerosis. Treatments attempt to improve function after an attack and prevent new attacks. Medications used to treat MS, while modestly effective, can have side effects and be poorly tolerated Multiple sclerosis usually starts with an acute episode of neurological disturbance, termed a 'clinically isolated syndrome', followed by an illness phase punctuated by relapses and remissions which may transition after 10 years to a phase of progressive accumulation of disability without relapses. Fifteen to 20% of patients will have a progressive course from the onset. There is significant interpatient variability in prognosis. The main diagnostic criteria are clinical, supported by investigations including magnetic resonance imaging and lumbar puncture and evoked potentials. First line disease modifying agents for relapsing remitting multiple sclerosis include interferon-ß and glatiramer. First line treatment for relapses is usually intravenous methylprednisolone for 3 days. Troublesome symptoms may include spasticity, parasthesias, tremor, erectile dysfunction, depression and anxiety, fatigue and pain. After excluding differential diagnoses, symptomatic management includes pharmacological agents, allied health consultation and continence strategies. Although pregnancy reduces disease activity, there is a higher risk of relapse in the postpartum period.","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"7 1","pages":"180-194"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74251617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/WJPR201711-9599
W. Shanthi
In the present study Poly(N-cyclohexylacrylamide-co-acrylamide-2acrylamido-2-methyl-1propane sodium sulfonate) Ag nanocomposite hydrogels was synthesized by in situ free-radical copolymerization in water/methanol medium using ammonium persulfate as the initiator, tetramethylethylenediamine as accelerator and N,N’methylenediaminde as cross-linker at 60oC. Analysis and characterization of the silver nanocomposite hydrogel was performed through monitoring its swelling behavior, diffusion studies, FTIR spectroscopy, SEM/EDX and XRD studies. Effects of monomer ratio on the swelling properties of the samples were investigated. Samples were used to remove organic dye (methylene blue) and heavy metal ion (Cd 2+ ) from aqueous solution and it was found that increase in monomer concentration into the hydrogel network increased the adsorption capacity of the silver nanocomposite hydrogel.
{"title":"SYNTHESIS, CHARACTERIZATION, SWELLING BEHAVIOR AND DIFFUSION STUDIES OF POLY(N-CYCLOHEXYLACRYLAMIDECO- ACRYLAMIDE-2-ACRYLAMIDO-2-METHYLPROPANE SODIUM SULPHONATE) SILVER NANOCOMPOSITE HYDROGELS","authors":"W. Shanthi","doi":"10.20959/WJPR201711-9599","DOIUrl":"https://doi.org/10.20959/WJPR201711-9599","url":null,"abstract":"In the present study Poly(N-cyclohexylacrylamide-co-acrylamide-2acrylamido-2-methyl-1propane sodium sulfonate) Ag nanocomposite hydrogels was synthesized by in situ free-radical copolymerization in water/methanol medium using ammonium persulfate as the initiator, tetramethylethylenediamine as accelerator and N,N’methylenediaminde as cross-linker at 60oC. Analysis and characterization of the silver nanocomposite hydrogel was performed through monitoring its swelling behavior, diffusion studies, FTIR spectroscopy, SEM/EDX and XRD studies. Effects of monomer ratio on the swelling properties of the samples were investigated. Samples were used to remove organic dye (methylene blue) and heavy metal ion (Cd 2+ ) from aqueous solution and it was found that increase in monomer concentration into the hydrogel network increased the adsorption capacity of the silver nanocomposite hydrogel.","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"3 1","pages":"866-877"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73374417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/WJPR201711-9629
M. Meena
Duchenne muscular dystrophy (DMD) is the most common muscular dystrophy caused by the absence of dystrophin gene. It is an X-linked inherited disorder without involvement of nervous system, progressive degeneration of group of muscle characterized by mildly delayed motor milestones, slow and progressive muscle weakness start presenting soon after the age of 3 years. Severe weakness and wasting occurs in proximal muscles of lower limbs. The Incidence of Duchenne muscular dystrophy is 1 in 3500 live male. Most common cause of death in DMD is cardiomyopathy and respiratory insufficiency. In modern medicine no successful therapy for treating DMD cases except corticosteroid‟s i.e. Deflazacort. Muscular dystrophy cannot be directly co-related with any single disease in Ayurvedic texts. It can be correlated to Vata vyadhi in Ayurvedic text. In Ayurveda muscular dystrophy may be clearly understood by the concept of Adhi bala pravritta vyadhi here the pathogenesis occurs due to the Beeja bhagavayava dusti which leads to Mamsa vata dushti. The present review article reveals highlights on various Ayurvedic medicines along with Panchkarma (Snehan, SSPS, and Basti karma) therapy for treatment and prevention of muscular dystrophy.
{"title":"A REVIEW ARTICLE ON MUSCULAR DYSTROPHY AND ITS MANAGEMENT THROUGH AYURVEDA","authors":"M. Meena","doi":"10.20959/WJPR201711-9629","DOIUrl":"https://doi.org/10.20959/WJPR201711-9629","url":null,"abstract":"Duchenne muscular dystrophy (DMD) is the most common muscular dystrophy caused by the absence of dystrophin gene. It is an X-linked inherited disorder without involvement of nervous system, progressive degeneration of group of muscle characterized by mildly delayed motor milestones, slow and progressive muscle weakness start presenting soon after the age of 3 years. Severe weakness and wasting occurs in proximal muscles of lower limbs. The Incidence of Duchenne muscular dystrophy is 1 in 3500 live male. Most common cause of death in DMD is cardiomyopathy and respiratory insufficiency. In modern medicine no successful therapy for treating DMD cases except corticosteroid‟s i.e. Deflazacort. Muscular dystrophy cannot be directly co-related with any single disease in Ayurvedic texts. It can be correlated to Vata vyadhi in Ayurvedic text. In Ayurveda muscular dystrophy may be clearly understood by the concept of Adhi bala pravritta vyadhi here the pathogenesis occurs due to the Beeja bhagavayava dusti which leads to Mamsa vata dushti. The present review article reveals highlights on various Ayurvedic medicines along with Panchkarma (Snehan, SSPS, and Basti karma) therapy for treatment and prevention of muscular dystrophy.","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"18 1","pages":"378-388"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81382918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/WJPR201711-9545
D. Gorai
The chemical investigation of methanol extract of the aerial parts of P. pterocarpum belonging to the family Leguminosae led to the isolation of an isoflavone, mexitin. The isolated compound was characterized using various spectroscopic data as well as chemical studies.
{"title":"AN ISOFLAVONE FROM PELTOPHORUM PTEROCARPUM","authors":"D. Gorai","doi":"10.20959/WJPR201711-9545","DOIUrl":"https://doi.org/10.20959/WJPR201711-9545","url":null,"abstract":"The chemical investigation of methanol extract of the aerial parts of P. pterocarpum belonging to the family Leguminosae led to the isolation of an isoflavone, mexitin. The isolated compound was characterized using various spectroscopic data as well as chemical studies.","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"61 1","pages":"718-722"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83697320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/wjpr201711-9568
Madhulika Pathak
Datura metel Linn. is a well known herbal drug and easily available worldwide. Ayurveda has mentioned mainly two types of poison – sthavara and jangama visha, Datura is included under sthavara visha. All parts of Datura are poisonous but seeds are more toxic as compared to the parts of the plant. To reduce the toxicity of a noxious drug Ayurveda mentions samaskara (procedure) known as shodhana (purification). The phytochemical analysis is very effective to see the active principles of plant to check its therapeutic value. The present study will evaluate the same through physicochemical parameters in Ashodita (unpurified) and Shodhita (purified) Datura beeja. After the analysis of the Datura beeja reduction of percentage of total ash, loss on drying and increase in the extractive values of Shodhita Datura beeja as compared to the Ashodita Datura beeja. Thus the current study shows the importance of Shodhana samskara to minimize the toxicity of the drug.
{"title":"TO EVALUATE THE EFFECT OF SHODHANA SAMSKARA OF ASHODHITA AND SHODHITA DATURA BEEJA – A ANALYTICAL STUDY","authors":"Madhulika Pathak","doi":"10.20959/wjpr201711-9568","DOIUrl":"https://doi.org/10.20959/wjpr201711-9568","url":null,"abstract":"Datura metel Linn. is a well known herbal drug and easily available worldwide. Ayurveda has mentioned mainly two types of poison – sthavara and jangama visha, Datura is included under sthavara visha. All parts of Datura are poisonous but seeds are more toxic as compared to the parts of the plant. To reduce the toxicity of a noxious drug Ayurveda mentions samaskara (procedure) known as shodhana (purification). The phytochemical analysis is very effective to see the active principles of plant to check its therapeutic value. The present study will evaluate the same through physicochemical parameters in Ashodita (unpurified) and Shodhita (purified) Datura beeja. After the analysis of the Datura beeja reduction of percentage of total ash, loss on drying and increase in the extractive values of Shodhita Datura beeja as compared to the Ashodita Datura beeja. Thus the current study shows the importance of Shodhana samskara to minimize the toxicity of the drug.","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"67 1","pages":"823-829"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82609448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/WJPR201711-9539
Monika Solanki
ABSTARCT Behavioral problem in young children is Very common. Enuresis is defined as the voluntary or involuntary repeated discharge of urine into clothes or bed. This problem greatly affects psychosocial life of child as well as family members. It affects small to middle age group of children mainly. It is considered as multifactorial behavioral disorder.1 In Ayurvedic classics, the brief description regarding Shayyamutra is found in Sharangadhara2 and Vangasena Samhita3. This disease mainly involved Vata (Apan Vayu), Pitta (Pachaka), Kapha (Tarpaka), along with Manasika Dosha Tama. There are many treatment option are now available for disease but traditionally very less information was available for the same. Medhya Rasayana is compound of Ayurvedic formulation mentioned in Charak Samhita text for the treatment of various psychiatry illnesses4. Medhya Rasayana contais Brahmi, Shankhapushpi, Yastimadhu, Guduchi. The present study was carried out to standardize the finished product Medhya rasayana to confirm its identity, purity and quality. The presence of Epidermal cells, Colonchyma cells, Starch grains, Covering trichoma, Crystal fibers, Pitted vessels, Rhomboidal crystals, Cork cell etc were the characteristic features of observed in microscopy of drug. Physico chemical analysis shows loss on drying is 4.88% w/w, water soluble extract is 13.9% w/w, methanol soluble extract is 9.48% w/w, ash value is 5.20% w/w and PH is 6.0. High Performance Thin Layer Chromatography (HPTLC) at 254 nm and 366 nm resulted into 8 & 7 spots respectively. World Journal of Pharmaceutical Research SJIF Imp ct Factor 7.523 Volume 6, Issue 11, 668-675. Research Article ISSN 2277– 7105
{"title":"PHARMACOGNOSTICAL AND PHARMACEUTICAL EVALUATION OF MEDHYA RASAYANA TABLET- A COMPOUND AYURVEDIC FORMULATION","authors":"Monika Solanki","doi":"10.20959/WJPR201711-9539","DOIUrl":"https://doi.org/10.20959/WJPR201711-9539","url":null,"abstract":"ABSTARCT Behavioral problem in young children is Very common. Enuresis is defined as the voluntary or involuntary repeated discharge of urine into clothes or bed. This problem greatly affects psychosocial life of child as well as family members. It affects small to middle age group of children mainly. It is considered as multifactorial behavioral disorder.1 In Ayurvedic classics, the brief description regarding Shayyamutra is found in Sharangadhara2 and Vangasena Samhita3. This disease mainly involved Vata (Apan Vayu), Pitta (Pachaka), Kapha (Tarpaka), along with Manasika Dosha Tama. There are many treatment option are now available for disease but traditionally very less information was available for the same. Medhya Rasayana is compound of Ayurvedic formulation mentioned in Charak Samhita text for the treatment of various psychiatry illnesses4. Medhya Rasayana contais Brahmi, Shankhapushpi, Yastimadhu, Guduchi. The present study was carried out to standardize the finished product Medhya rasayana to confirm its identity, purity and quality. The presence of Epidermal cells, Colonchyma cells, Starch grains, Covering trichoma, Crystal fibers, Pitted vessels, Rhomboidal crystals, Cork cell etc were the characteristic features of observed in microscopy of drug. Physico chemical analysis shows loss on drying is 4.88% w/w, water soluble extract is 13.9% w/w, methanol soluble extract is 9.48% w/w, ash value is 5.20% w/w and PH is 6.0. High Performance Thin Layer Chromatography (HPTLC) at 254 nm and 366 nm resulted into 8 & 7 spots respectively. World Journal of Pharmaceutical Research SJIF Imp ct Factor 7.523 Volume 6, Issue 11, 668-675. Research Article ISSN 2277– 7105","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"99 1","pages":"668-675"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79293891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/WJPR201711-9514
D. Devi
{"title":"ISOLATION AND CHARACTERIZATION OF LOW DENSITY POLYETHYLENE DEGRADING BACILLUS SPP. FROM GARBAGE DUMP SITES","authors":"D. Devi","doi":"10.20959/WJPR201711-9514","DOIUrl":"https://doi.org/10.20959/WJPR201711-9514","url":null,"abstract":"","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"17 1","pages":"609-617"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80306918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/wjpr201711-9493
P. Ancy
The plant Muehlenbeckia platyclada belonging to Polygonaceae family has great importance in traditional medicine. It is popular remedy in various ethnic groups. Extensive studies show the presence of flavanoid glycosides in it. Muehlenbeckia platyclada is found to possess antinociceptive and analgesic activity. This work gives an overview of phytochemical and pharmacological evidence of Muehlenbeckia platyclada. Although more studies are necessary to explore therapeutic potential of the plant as it has more therapeutic activities which are not known.
{"title":"MUEHLENBECKIA PLATYCLADA (POLYGONACEAE) AN OVERVIEW","authors":"P. Ancy","doi":"10.20959/wjpr201711-9493","DOIUrl":"https://doi.org/10.20959/wjpr201711-9493","url":null,"abstract":"The plant Muehlenbeckia platyclada belonging to Polygonaceae family has great importance in traditional medicine. It is popular remedy in various ethnic groups. Extensive studies show the presence of flavanoid glycosides in it. Muehlenbeckia platyclada is found to possess antinociceptive and analgesic activity. This work gives an overview of phytochemical and pharmacological evidence of Muehlenbeckia platyclada. Although more studies are necessary to explore therapeutic potential of the plant as it has more therapeutic activities which are not known.","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"25 1","pages":"195-199"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87260538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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