Pub Date : 2017-11-01DOI: 10.20959/WJPR201711-9599
W. Shanthi
In the present study Poly(N-cyclohexylacrylamide-co-acrylamide-2acrylamido-2-methyl-1propane sodium sulfonate) Ag nanocomposite hydrogels was synthesized by in situ free-radical copolymerization in water/methanol medium using ammonium persulfate as the initiator, tetramethylethylenediamine as accelerator and N,N’methylenediaminde as cross-linker at 60oC. Analysis and characterization of the silver nanocomposite hydrogel was performed through monitoring its swelling behavior, diffusion studies, FTIR spectroscopy, SEM/EDX and XRD studies. Effects of monomer ratio on the swelling properties of the samples were investigated. Samples were used to remove organic dye (methylene blue) and heavy metal ion (Cd 2+ ) from aqueous solution and it was found that increase in monomer concentration into the hydrogel network increased the adsorption capacity of the silver nanocomposite hydrogel.
{"title":"SYNTHESIS, CHARACTERIZATION, SWELLING BEHAVIOR AND DIFFUSION STUDIES OF POLY(N-CYCLOHEXYLACRYLAMIDECO- ACRYLAMIDE-2-ACRYLAMIDO-2-METHYLPROPANE SODIUM SULPHONATE) SILVER NANOCOMPOSITE HYDROGELS","authors":"W. Shanthi","doi":"10.20959/WJPR201711-9599","DOIUrl":"https://doi.org/10.20959/WJPR201711-9599","url":null,"abstract":"In the present study Poly(N-cyclohexylacrylamide-co-acrylamide-2acrylamido-2-methyl-1propane sodium sulfonate) Ag nanocomposite hydrogels was synthesized by in situ free-radical copolymerization in water/methanol medium using ammonium persulfate as the initiator, tetramethylethylenediamine as accelerator and N,N’methylenediaminde as cross-linker at 60oC. Analysis and characterization of the silver nanocomposite hydrogel was performed through monitoring its swelling behavior, diffusion studies, FTIR spectroscopy, SEM/EDX and XRD studies. Effects of monomer ratio on the swelling properties of the samples were investigated. Samples were used to remove organic dye (methylene blue) and heavy metal ion (Cd 2+ ) from aqueous solution and it was found that increase in monomer concentration into the hydrogel network increased the adsorption capacity of the silver nanocomposite hydrogel.","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"3 1","pages":"866-877"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73374417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/WJPR201711-9539
Monika Solanki
ABSTARCT Behavioral problem in young children is Very common. Enuresis is defined as the voluntary or involuntary repeated discharge of urine into clothes or bed. This problem greatly affects psychosocial life of child as well as family members. It affects small to middle age group of children mainly. It is considered as multifactorial behavioral disorder.1 In Ayurvedic classics, the brief description regarding Shayyamutra is found in Sharangadhara2 and Vangasena Samhita3. This disease mainly involved Vata (Apan Vayu), Pitta (Pachaka), Kapha (Tarpaka), along with Manasika Dosha Tama. There are many treatment option are now available for disease but traditionally very less information was available for the same. Medhya Rasayana is compound of Ayurvedic formulation mentioned in Charak Samhita text for the treatment of various psychiatry illnesses4. Medhya Rasayana contais Brahmi, Shankhapushpi, Yastimadhu, Guduchi. The present study was carried out to standardize the finished product Medhya rasayana to confirm its identity, purity and quality. The presence of Epidermal cells, Colonchyma cells, Starch grains, Covering trichoma, Crystal fibers, Pitted vessels, Rhomboidal crystals, Cork cell etc were the characteristic features of observed in microscopy of drug. Physico chemical analysis shows loss on drying is 4.88% w/w, water soluble extract is 13.9% w/w, methanol soluble extract is 9.48% w/w, ash value is 5.20% w/w and PH is 6.0. High Performance Thin Layer Chromatography (HPTLC) at 254 nm and 366 nm resulted into 8 & 7 spots respectively. World Journal of Pharmaceutical Research SJIF Imp ct Factor 7.523 Volume 6, Issue 11, 668-675. Research Article ISSN 2277– 7105
{"title":"PHARMACOGNOSTICAL AND PHARMACEUTICAL EVALUATION OF MEDHYA RASAYANA TABLET- A COMPOUND AYURVEDIC FORMULATION","authors":"Monika Solanki","doi":"10.20959/WJPR201711-9539","DOIUrl":"https://doi.org/10.20959/WJPR201711-9539","url":null,"abstract":"ABSTARCT Behavioral problem in young children is Very common. Enuresis is defined as the voluntary or involuntary repeated discharge of urine into clothes or bed. This problem greatly affects psychosocial life of child as well as family members. It affects small to middle age group of children mainly. It is considered as multifactorial behavioral disorder.1 In Ayurvedic classics, the brief description regarding Shayyamutra is found in Sharangadhara2 and Vangasena Samhita3. This disease mainly involved Vata (Apan Vayu), Pitta (Pachaka), Kapha (Tarpaka), along with Manasika Dosha Tama. There are many treatment option are now available for disease but traditionally very less information was available for the same. Medhya Rasayana is compound of Ayurvedic formulation mentioned in Charak Samhita text for the treatment of various psychiatry illnesses4. Medhya Rasayana contais Brahmi, Shankhapushpi, Yastimadhu, Guduchi. The present study was carried out to standardize the finished product Medhya rasayana to confirm its identity, purity and quality. The presence of Epidermal cells, Colonchyma cells, Starch grains, Covering trichoma, Crystal fibers, Pitted vessels, Rhomboidal crystals, Cork cell etc were the characteristic features of observed in microscopy of drug. Physico chemical analysis shows loss on drying is 4.88% w/w, water soluble extract is 13.9% w/w, methanol soluble extract is 9.48% w/w, ash value is 5.20% w/w and PH is 6.0. High Performance Thin Layer Chromatography (HPTLC) at 254 nm and 366 nm resulted into 8 & 7 spots respectively. World Journal of Pharmaceutical Research SJIF Imp ct Factor 7.523 Volume 6, Issue 11, 668-675. Research Article ISSN 2277– 7105","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"99 1","pages":"668-675"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79293891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/WJPR201711-9514
D. Devi
{"title":"ISOLATION AND CHARACTERIZATION OF LOW DENSITY POLYETHYLENE DEGRADING BACILLUS SPP. FROM GARBAGE DUMP SITES","authors":"D. Devi","doi":"10.20959/WJPR201711-9514","DOIUrl":"https://doi.org/10.20959/WJPR201711-9514","url":null,"abstract":"","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"17 1","pages":"609-617"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80306918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/WJPR201711-9629
M. Meena
Duchenne muscular dystrophy (DMD) is the most common muscular dystrophy caused by the absence of dystrophin gene. It is an X-linked inherited disorder without involvement of nervous system, progressive degeneration of group of muscle characterized by mildly delayed motor milestones, slow and progressive muscle weakness start presenting soon after the age of 3 years. Severe weakness and wasting occurs in proximal muscles of lower limbs. The Incidence of Duchenne muscular dystrophy is 1 in 3500 live male. Most common cause of death in DMD is cardiomyopathy and respiratory insufficiency. In modern medicine no successful therapy for treating DMD cases except corticosteroid‟s i.e. Deflazacort. Muscular dystrophy cannot be directly co-related with any single disease in Ayurvedic texts. It can be correlated to Vata vyadhi in Ayurvedic text. In Ayurveda muscular dystrophy may be clearly understood by the concept of Adhi bala pravritta vyadhi here the pathogenesis occurs due to the Beeja bhagavayava dusti which leads to Mamsa vata dushti. The present review article reveals highlights on various Ayurvedic medicines along with Panchkarma (Snehan, SSPS, and Basti karma) therapy for treatment and prevention of muscular dystrophy.
{"title":"A REVIEW ARTICLE ON MUSCULAR DYSTROPHY AND ITS MANAGEMENT THROUGH AYURVEDA","authors":"M. Meena","doi":"10.20959/WJPR201711-9629","DOIUrl":"https://doi.org/10.20959/WJPR201711-9629","url":null,"abstract":"Duchenne muscular dystrophy (DMD) is the most common muscular dystrophy caused by the absence of dystrophin gene. It is an X-linked inherited disorder without involvement of nervous system, progressive degeneration of group of muscle characterized by mildly delayed motor milestones, slow and progressive muscle weakness start presenting soon after the age of 3 years. Severe weakness and wasting occurs in proximal muscles of lower limbs. The Incidence of Duchenne muscular dystrophy is 1 in 3500 live male. Most common cause of death in DMD is cardiomyopathy and respiratory insufficiency. In modern medicine no successful therapy for treating DMD cases except corticosteroid‟s i.e. Deflazacort. Muscular dystrophy cannot be directly co-related with any single disease in Ayurvedic texts. It can be correlated to Vata vyadhi in Ayurvedic text. In Ayurveda muscular dystrophy may be clearly understood by the concept of Adhi bala pravritta vyadhi here the pathogenesis occurs due to the Beeja bhagavayava dusti which leads to Mamsa vata dushti. The present review article reveals highlights on various Ayurvedic medicines along with Panchkarma (Snehan, SSPS, and Basti karma) therapy for treatment and prevention of muscular dystrophy.","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"18 1","pages":"378-388"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81382918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/wjpr201711-9596
Rayappa Mahale
{"title":"ANTIMICROBIAL APPLICATION OF SCHIFF’S BASE AND IT’S METAL COMPLEXES: A REVIEW","authors":"Rayappa Mahale","doi":"10.20959/wjpr201711-9596","DOIUrl":"https://doi.org/10.20959/wjpr201711-9596","url":null,"abstract":"","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"26 1","pages":"312-320"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76361709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/WJPR201711-9650
N. M. Rao
The present invention relates to an improved process for the alkylation of 3, 4dihydroxythiophene-2, 5-dicarboxylic esters or their alkali metal or alkaline earth metal salts with alkylating agent and base in the presence of a solvent and catalyst PEG-400 was used as a Phase transfer Catalyst and could effectively catalyze the Reaction.
{"title":"POLYETHYLENE GLYCOL (PEG-400): AN EFFICIENT GREEN REACTION MEDIUM FOR THE ALKYLATION OF 3, 4-DIHYDROXY THIOPHENE-2, 5-DICARBOXYLIC ESTERS OR THEIR ALKALI METAL OR ALKALINE EARTH METAL SALTS.","authors":"N. M. Rao","doi":"10.20959/WJPR201711-9650","DOIUrl":"https://doi.org/10.20959/WJPR201711-9650","url":null,"abstract":"The present invention relates to an improved process for the alkylation of 3, 4dihydroxythiophene-2, 5-dicarboxylic esters or their alkali metal or alkaline earth metal salts with alkylating agent and base in the presence of a solvent and catalyst PEG-400 was used as a Phase transfer Catalyst and could effectively catalyze the Reaction.","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"418 1","pages":"1003-1009"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76475384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/wjpr201711-9493
P. Ancy
The plant Muehlenbeckia platyclada belonging to Polygonaceae family has great importance in traditional medicine. It is popular remedy in various ethnic groups. Extensive studies show the presence of flavanoid glycosides in it. Muehlenbeckia platyclada is found to possess antinociceptive and analgesic activity. This work gives an overview of phytochemical and pharmacological evidence of Muehlenbeckia platyclada. Although more studies are necessary to explore therapeutic potential of the plant as it has more therapeutic activities which are not known.
{"title":"MUEHLENBECKIA PLATYCLADA (POLYGONACEAE) AN OVERVIEW","authors":"P. Ancy","doi":"10.20959/wjpr201711-9493","DOIUrl":"https://doi.org/10.20959/wjpr201711-9493","url":null,"abstract":"The plant Muehlenbeckia platyclada belonging to Polygonaceae family has great importance in traditional medicine. It is popular remedy in various ethnic groups. Extensive studies show the presence of flavanoid glycosides in it. Muehlenbeckia platyclada is found to possess antinociceptive and analgesic activity. This work gives an overview of phytochemical and pharmacological evidence of Muehlenbeckia platyclada. Although more studies are necessary to explore therapeutic potential of the plant as it has more therapeutic activities which are not known.","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"25 1","pages":"195-199"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87260538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/wjpr201711-9568
Madhulika Pathak
Datura metel Linn. is a well known herbal drug and easily available worldwide. Ayurveda has mentioned mainly two types of poison – sthavara and jangama visha, Datura is included under sthavara visha. All parts of Datura are poisonous but seeds are more toxic as compared to the parts of the plant. To reduce the toxicity of a noxious drug Ayurveda mentions samaskara (procedure) known as shodhana (purification). The phytochemical analysis is very effective to see the active principles of plant to check its therapeutic value. The present study will evaluate the same through physicochemical parameters in Ashodita (unpurified) and Shodhita (purified) Datura beeja. After the analysis of the Datura beeja reduction of percentage of total ash, loss on drying and increase in the extractive values of Shodhita Datura beeja as compared to the Ashodita Datura beeja. Thus the current study shows the importance of Shodhana samskara to minimize the toxicity of the drug.
{"title":"TO EVALUATE THE EFFECT OF SHODHANA SAMSKARA OF ASHODHITA AND SHODHITA DATURA BEEJA – A ANALYTICAL STUDY","authors":"Madhulika Pathak","doi":"10.20959/wjpr201711-9568","DOIUrl":"https://doi.org/10.20959/wjpr201711-9568","url":null,"abstract":"Datura metel Linn. is a well known herbal drug and easily available worldwide. Ayurveda has mentioned mainly two types of poison – sthavara and jangama visha, Datura is included under sthavara visha. All parts of Datura are poisonous but seeds are more toxic as compared to the parts of the plant. To reduce the toxicity of a noxious drug Ayurveda mentions samaskara (procedure) known as shodhana (purification). The phytochemical analysis is very effective to see the active principles of plant to check its therapeutic value. The present study will evaluate the same through physicochemical parameters in Ashodita (unpurified) and Shodhita (purified) Datura beeja. After the analysis of the Datura beeja reduction of percentage of total ash, loss on drying and increase in the extractive values of Shodhita Datura beeja as compared to the Ashodita Datura beeja. Thus the current study shows the importance of Shodhana samskara to minimize the toxicity of the drug.","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"67 1","pages":"823-829"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82609448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/WJPR201711-9272
S. Parveen
Neurological diseases are gaining more importance in the developing countries like India in recent times. Epilepsy is one of the most important neurological disorders. It describes a condition in which a person experience recurrent seizures due to a chronic, underlying process. A Prospective Observational study was carried out at Rajiv Gandhi Institute of Medical Sciences, Kadapa. A total of 65 patients were selected in a 6 months period based upon the inclusion and exclusion criteria. In the present study we made an attempt to conduct Drug utilization evaluation (DUE) in epileptic patients to improve treatment rationality in a tertiary care teaching hospital. Demographic and prescription data was collected and assessed based upon the DUE. From that we found that generalized seizures were the most prominent seizure encountered and monotherapy was the most frequently used treatment in all types of epileptic seizures. Our data suggests that unknown cause and stress is main offender of symptomatic epilepsy. Furthermore, we observed that there was some inappropriate usage of Anti-epileptic drugs which comprises drug-drug interaction and incorrect dosage regimen. we found generalized seizures were the most prominent seizure encountered and monotherapy was the most frequently used treatment in all types of epileptic seizures. Most commonly prescribed drug was Phenytoin. We found ADRs, medication errors and drug interactions in World Journal of Pharmaceutical Research SJIF Impact Factor 7.523 Volume 6, Issue 11, 453-469. Research Article ISSN 2277– 7105 Article Received on 01 August 2017, Revised on 22 August 2017, Accepted on 12 Sept. 2017 DOI: 10.20959/wjpr201711-9272
近年来，神经系统疾病在印度等发展中国家变得越来越重要。癫痫是最重要的神经系统疾病之一。它描述了一种情况，其中一个人经历反复发作，由于慢性的，潜在的过程。在卡达帕拉吉夫·甘地医学科学研究所进行了一项前瞻性观察研究。根据纳入和排除标准，在6个月内共选择65例患者。本研究尝试对某三级教学医院的癫痫患者进行药物利用评价(DUE)，以提高治疗的合理性。根据DUE收集和评估人口统计和处方数据。由此我们发现全面性癫痫发作是最突出的癫痫发作，单一疗法是所有类型癫痫发作中最常用的治疗方法。我们的数据表明，未知的原因和压力是症状性癫痫的主要肇事者。此外，我们还观察到一些抗癫痫药物的不当使用，包括药物相互作用和不正确的给药方案。我们发现全面性癫痫发作是最突出的癫痫发作，单一疗法是所有类型癫痫发作中最常用的治疗方法。最常用的处方药是苯妥英。我们在《World Journal of Pharmaceutical Research》SJIF影响因子7.523卷第6期第11期453-469中发现了adr、用药错误和药物相互作用。文章收稿于2017年8月1日，修订于2017年8月22日，收稿于2017年9月12日DOI: 10.20959/wjpr201711-9272
{"title":"DRUG UTILIZATION EVALUATION OF ANTI-EPILEPTICS IN A TERTIARY CARE TEACHING HOSPITAL","authors":"S. Parveen","doi":"10.20959/WJPR201711-9272","DOIUrl":"https://doi.org/10.20959/WJPR201711-9272","url":null,"abstract":"Neurological diseases are gaining more importance in the developing countries like India in recent times. Epilepsy is one of the most important neurological disorders. It describes a condition in which a person experience recurrent seizures due to a chronic, underlying process. A Prospective Observational study was carried out at Rajiv Gandhi Institute of Medical Sciences, Kadapa. A total of 65 patients were selected in a 6 months period based upon the inclusion and exclusion criteria. In the present study we made an attempt to conduct Drug utilization evaluation (DUE) in epileptic patients to improve treatment rationality in a tertiary care teaching hospital. Demographic and prescription data was collected and assessed based upon the DUE. From that we found that generalized seizures were the most prominent seizure encountered and monotherapy was the most frequently used treatment in all types of epileptic seizures. Our data suggests that unknown cause and stress is main offender of symptomatic epilepsy. Furthermore, we observed that there was some inappropriate usage of Anti-epileptic drugs which comprises drug-drug interaction and incorrect dosage regimen. we found generalized seizures were the most prominent seizure encountered and monotherapy was the most frequently used treatment in all types of epileptic seizures. Most commonly prescribed drug was Phenytoin. We found ADRs, medication errors and drug interactions in World Journal of Pharmaceutical Research SJIF Impact Factor 7.523 Volume 6, Issue 11, 453-469. Research Article ISSN 2277– 7105 Article Received on 01 August 2017, Revised on 22 August 2017, Accepted on 12 Sept. 2017 DOI: 10.20959/wjpr201711-9272","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"62 5 1","pages":"453-469"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91373141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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