Pub Date : 2026-02-20DOI: 10.3760/cma.j.cn121094-20241231-00595
Y Y Yu, C X Wang, J Meng, H X Liu, X J Sun, S J Gao
Methyl mercaptan is a colorless gas with strong foul odor. Inhalation poisoning often causes serious damage to the nervous system and respiratory system. This article retrospectively analyzed a case of acute respiratory distress syndrome (ARDS) caused by methyl mercaptan inhalation poisoning treated at Weifang People's Hospital, and elaborated its clinical manifestations, examination results and diagnosis and treatment process. After early application of sufficient glucocorticoids, extracorporeal membrance oxygenation (ECMO) replacement therapy, bronchoscopic lung lavage and active comprehensive treatment measures, the patient was successfully treated, recovered and discharged.
{"title":"[A case of acute respiratory distress syndrome caused by occupational acute methyl mercaptan poisoning].","authors":"Y Y Yu, C X Wang, J Meng, H X Liu, X J Sun, S J Gao","doi":"10.3760/cma.j.cn121094-20241231-00595","DOIUrl":"https://doi.org/10.3760/cma.j.cn121094-20241231-00595","url":null,"abstract":"<p><p>Methyl mercaptan is a colorless gas with strong foul odor. Inhalation poisoning often causes serious damage to the nervous system and respiratory system. This article retrospectively analyzed a case of acute respiratory distress syndrome (ARDS) caused by methyl mercaptan inhalation poisoning treated at Weifang People's Hospital, and elaborated its clinical manifestations, examination results and diagnosis and treatment process. After early application of sufficient glucocorticoids, extracorporeal membrance oxygenation (ECMO) replacement therapy, bronchoscopic lung lavage and active comprehensive treatment measures, the patient was successfully treated, recovered and discharged.</p>","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"44 2","pages":"149-151"},"PeriodicalIF":0.0,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147285411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-20DOI: 10.3760/cma.j.cn121094-20240629-00288
T Luan, Y Liang, J J Zhang, L M Luo, L Qin, H Zhang
Cryptococcus is an opportunistic pathogen, which belongs to yeast-type fungi. It mainly exists in bird droppings, rotten wood and soil. Respiratory tract is the main portal of invasion. It can occur in immunocompromised and immunocompetent hosts. The clinical manifestations, symptoms, signs and imaging of pulmonary cryptococcosis caused by it have no obvious specificity, which may lead to misdiagnosis and mistreatment. This article reported a case of a patient with atelectasis complicated by cryptococcal pneumonia, diagnosed and treated at Qingdao Central Hospital of Health and Rehabilitation Sciences University in January 2024. The patient had a history of close dust exposure, wet underground work, the possibility of inhaling cryptococcal dust, and occupational environmental risk factors. The next-generation sequencing report (NGS) of alveolar lavage fluid detected Cryptococcus neoformans and diagnosed as Cryptococcus neoformans pneumonia.
{"title":"[A case of pulmonary cryptococcosis in dust-exposed worker].","authors":"T Luan, Y Liang, J J Zhang, L M Luo, L Qin, H Zhang","doi":"10.3760/cma.j.cn121094-20240629-00288","DOIUrl":"https://doi.org/10.3760/cma.j.cn121094-20240629-00288","url":null,"abstract":"<p><p>Cryptococcus is an opportunistic pathogen, which belongs to yeast-type fungi. It mainly exists in bird droppings, rotten wood and soil. Respiratory tract is the main portal of invasion. It can occur in immunocompromised and immunocompetent hosts. The clinical manifestations, symptoms, signs and imaging of pulmonary cryptococcosis caused by it have no obvious specificity, which may lead to misdiagnosis and mistreatment. This article reported a case of a patient with atelectasis complicated by cryptococcal pneumonia, diagnosed and treated at Qingdao Central Hospital of Health and Rehabilitation Sciences University in January 2024. The patient had a history of close dust exposure, wet underground work, the possibility of inhaling cryptococcal dust, and occupational environmental risk factors. The next-generation sequencing report (NGS) of alveolar lavage fluid detected Cryptococcus neoformans and diagnosed as Cryptococcus neoformans pneumonia.</p>","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"44 2","pages":"146-149"},"PeriodicalIF":0.0,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147285402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-20DOI: 10.3760/cma.j.cn121094-20241008-00456
L Qiu, H Q Wang, J J Bi, X J Wang, C F Yan, Z Liu, C X Wang
<p><p><b>Objective:</b> To compare the differences in brain region volumes between workers exposed to welding fume and those not exposed in magnetic resonance imaging (MRI), and to explore the characteristics of brain region volume changes in workers exposed to welding fume, in order to provide imaging-based diagnostic evidence for the neurological damage caused by welding fume. <b>Methods:</b> In July 2024, all workers exposed to welding fume in a certain machinery factory who underwent occupational health examinations at Zibo Occupational Disease Prevention Hospital were selected as the observation group (50 people), and 50 non-dust-exposed workers from the same region were selected using simple random sampling as the control group. Chest computed tomography (CT) examination and high-resolution cranial MRI scans were conducted on the workers, and the volumes of each brain region in MRI were automatically measured using the artificial intelligence-based brain structure analysis workstation. The independent sample <i>t</i>-test was used to compare the volume of the brain region and the percentage of the total intracranial volume between the two groups of workers, and Pearson correlation analysis was used to test the correlation between the volume of brain regions and the percentage of total intracranial volume with the dust exposure years and age. The critical values for abnormality of each indicator were determined based on the receiver operating characteristic (ROC) curve to obtain the binary variable, and the correlation with chest CT abnormalities was analyzed using the Phi coefficient. <b>Results:</b> The volume of the putamen in the observation group was (5.82±0.90) cm(3), and the percentage of the total intracranial volume was (0.39±0.05) %, which were both smaller than those of the control group [ (6.75±0.84) cm(3), (0.45±0.05) %] (<i>t</i>=-5.28, -5.81, <i>P</i><0.01). The volume of the globus pallidus [ (2.82±0.29) cm(3)] and the percentage[ (0.19±0.01) %] were both smaller than those of the control group[ (3.08±0.32) cm(3), (0.20±0.02) %] (<i>t</i>=-4.21, -4.98, <i>P</i><0.01). The percentage of the insula in the observation group [ (0.92±0.06) %] was greater than that of the control group[ (0.88±0.06) %] (<i>t</i>=3.26, <i>P</i><0.01). The volume of the thalamus in the observation group was (15.41±1.46) cm(3), and the percentage was (1.03±0.07) %, which were both greater than those of the control group [ (14.35±1.09) cm(3), (0.95±0.05) %] (<i>t</i>=4.10, 6.18, <i>P</i><0.01). The volumes or percentages of multiple brain regions such as the cingulate gyrus and globus pallidus in the observation group were negatively correlated with the duration of exposure to welding fume and age (<i>r</i>=-0.46 to -0.29, <i>P</i><0.05), and the volume or percentage of the ventricles were positively correlated with the duration of exposure to welding fume and age (<i>r</i>=0.45 to 0.54, <i>P</i><0.01). The percentage of cerebral white matter in the bra
{"title":"[MRI comparison of brain region volumes between welding fumes exposed and non-exposed workers].","authors":"L Qiu, H Q Wang, J J Bi, X J Wang, C F Yan, Z Liu, C X Wang","doi":"10.3760/cma.j.cn121094-20241008-00456","DOIUrl":"https://doi.org/10.3760/cma.j.cn121094-20241008-00456","url":null,"abstract":"<p><p><b>Objective:</b> To compare the differences in brain region volumes between workers exposed to welding fume and those not exposed in magnetic resonance imaging (MRI), and to explore the characteristics of brain region volume changes in workers exposed to welding fume, in order to provide imaging-based diagnostic evidence for the neurological damage caused by welding fume. <b>Methods:</b> In July 2024, all workers exposed to welding fume in a certain machinery factory who underwent occupational health examinations at Zibo Occupational Disease Prevention Hospital were selected as the observation group (50 people), and 50 non-dust-exposed workers from the same region were selected using simple random sampling as the control group. Chest computed tomography (CT) examination and high-resolution cranial MRI scans were conducted on the workers, and the volumes of each brain region in MRI were automatically measured using the artificial intelligence-based brain structure analysis workstation. The independent sample <i>t</i>-test was used to compare the volume of the brain region and the percentage of the total intracranial volume between the two groups of workers, and Pearson correlation analysis was used to test the correlation between the volume of brain regions and the percentage of total intracranial volume with the dust exposure years and age. The critical values for abnormality of each indicator were determined based on the receiver operating characteristic (ROC) curve to obtain the binary variable, and the correlation with chest CT abnormalities was analyzed using the Phi coefficient. <b>Results:</b> The volume of the putamen in the observation group was (5.82±0.90) cm(3), and the percentage of the total intracranial volume was (0.39±0.05) %, which were both smaller than those of the control group [ (6.75±0.84) cm(3), (0.45±0.05) %] (<i>t</i>=-5.28, -5.81, <i>P</i><0.01). The volume of the globus pallidus [ (2.82±0.29) cm(3)] and the percentage[ (0.19±0.01) %] were both smaller than those of the control group[ (3.08±0.32) cm(3), (0.20±0.02) %] (<i>t</i>=-4.21, -4.98, <i>P</i><0.01). The percentage of the insula in the observation group [ (0.92±0.06) %] was greater than that of the control group[ (0.88±0.06) %] (<i>t</i>=3.26, <i>P</i><0.01). The volume of the thalamus in the observation group was (15.41±1.46) cm(3), and the percentage was (1.03±0.07) %, which were both greater than those of the control group [ (14.35±1.09) cm(3), (0.95±0.05) %] (<i>t</i>=4.10, 6.18, <i>P</i><0.01). The volumes or percentages of multiple brain regions such as the cingulate gyrus and globus pallidus in the observation group were negatively correlated with the duration of exposure to welding fume and age (<i>r</i>=-0.46 to -0.29, <i>P</i><0.05), and the volume or percentage of the ventricles were positively correlated with the duration of exposure to welding fume and age (<i>r</i>=0.45 to 0.54, <i>P</i><0.01). The percentage of cerebral white matter in the bra","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"44 2","pages":"123-128"},"PeriodicalIF":0.0,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147285343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-20DOI: 10.3760/cma.j.cn121094-20240717-00317
Muheyati Guliman, J Q Wang, M Y Ding, N Tao
<p><p><b>Objective:</b> To explore the relationship between occupational stress and metabolic scores for insulin resistance (METS-IR) and metabolic score for visceral fat (METS-VF) and the risk of cardiovascular disease (CVD) in oil workers, and to provide theoretical basis for their health management. <b>Methods:</b> In April 2024 A cluster random sampling method was used to select 1910 workers aged 20 to 60 who had undergone physical examination in Karamay Central Hospital from September to November 2017 and whose length of service was ≥1 year as the research objects, collect the general data of the research objects, and use the Occupational Task Questionnaire (ORQ) subscale in the Revised Occupational Stress Scale (OSI-R) to assess their occupational stress level. According to the occupational stress score, workers wre divided into four groups: Q1 group (<155 points), Q2 group (155-<165 points), Q3 group (165-178 points), and Q4 group (>178 points) .Secondly, calculate the Framingham Risk Score (FRS) to quantify individual CVD risk. Individuals with a Framingham risk score of less than 10 are defined as the low-risk CVD group, while those with a Framingham risk score of ≥10 are defined as the medium to high risk CVD group. Using logistic regression combined with restricted cubic spline (RCS) model, analyze the relationship between occupational stress, METS-IR, METS-VF and CVD risk. Evaluate the predictive power of the above factors on the risk of CVD by plotting receiver operating characteristic (ROC) curves adjusted for covariates. <b>Results:</b> The age of the research subjects is (41.33±7.92) years old. There were 192 individuals in the high-risk group for CVD (10.1%), including 191 males (99.5%), 181 individuals with smoking (94.3%), 155 individuals with alcohol consumption (80.7%), and 107 individuals with shift work (55.7%) ; There were statistically significant differences in blood lipids, fasting blood glucose (FPG), body mass index (BMI), waist circumference (WC), blood pressure, uric acid, creatinine, ORQ, and metabolic score between the low-risk group and the medium high risk group (<i>P</i><0.05). After adjusting for confounding factors through logistic regression analysis, the results showed that compared with the Q4 group, the risk of CVD in Homo sapiens significantly increased in the Q1, Q2, and Q3 groups (<i>P</i><0.05) ; compared with the Q1 group, METS-IR in Homo sapiens was higher in the Q2, Q3, and Q4 groups (<i>P</i><0.05) ; compared with the Q1 group, the risk of METS-VF in Homo sapiens significantly increased in the Q3 and Q4 groups (<i>P</i><0.05) ; all exhibited a dose-response relationship (<i>P</i>(trend)<0.01). The AUC values for ORQ, METS-IR, and METS-VF were 0.937, 0.882, and 0.924, respectively. <b>Conclusion:</b> Occupational stress, METS-IR, and METS-VF exhibit complex interactions with CVD risk in petroleum industry Homo sapiens, increasing disease risk and demonstrating strong predictive capability for incid
{"title":"[The relationship between occupational stress and metabolic scores and cardiovascular disease risk among oil workers].","authors":"Muheyati Guliman, J Q Wang, M Y Ding, N Tao","doi":"10.3760/cma.j.cn121094-20240717-00317","DOIUrl":"https://doi.org/10.3760/cma.j.cn121094-20240717-00317","url":null,"abstract":"<p><p><b>Objective:</b> To explore the relationship between occupational stress and metabolic scores for insulin resistance (METS-IR) and metabolic score for visceral fat (METS-VF) and the risk of cardiovascular disease (CVD) in oil workers, and to provide theoretical basis for their health management. <b>Methods:</b> In April 2024 A cluster random sampling method was used to select 1910 workers aged 20 to 60 who had undergone physical examination in Karamay Central Hospital from September to November 2017 and whose length of service was ≥1 year as the research objects, collect the general data of the research objects, and use the Occupational Task Questionnaire (ORQ) subscale in the Revised Occupational Stress Scale (OSI-R) to assess their occupational stress level. According to the occupational stress score, workers wre divided into four groups: Q1 group (<155 points), Q2 group (155-<165 points), Q3 group (165-178 points), and Q4 group (>178 points) .Secondly, calculate the Framingham Risk Score (FRS) to quantify individual CVD risk. Individuals with a Framingham risk score of less than 10 are defined as the low-risk CVD group, while those with a Framingham risk score of ≥10 are defined as the medium to high risk CVD group. Using logistic regression combined with restricted cubic spline (RCS) model, analyze the relationship between occupational stress, METS-IR, METS-VF and CVD risk. Evaluate the predictive power of the above factors on the risk of CVD by plotting receiver operating characteristic (ROC) curves adjusted for covariates. <b>Results:</b> The age of the research subjects is (41.33±7.92) years old. There were 192 individuals in the high-risk group for CVD (10.1%), including 191 males (99.5%), 181 individuals with smoking (94.3%), 155 individuals with alcohol consumption (80.7%), and 107 individuals with shift work (55.7%) ; There were statistically significant differences in blood lipids, fasting blood glucose (FPG), body mass index (BMI), waist circumference (WC), blood pressure, uric acid, creatinine, ORQ, and metabolic score between the low-risk group and the medium high risk group (<i>P</i><0.05). After adjusting for confounding factors through logistic regression analysis, the results showed that compared with the Q4 group, the risk of CVD in Homo sapiens significantly increased in the Q1, Q2, and Q3 groups (<i>P</i><0.05) ; compared with the Q1 group, METS-IR in Homo sapiens was higher in the Q2, Q3, and Q4 groups (<i>P</i><0.05) ; compared with the Q1 group, the risk of METS-VF in Homo sapiens significantly increased in the Q3 and Q4 groups (<i>P</i><0.05) ; all exhibited a dose-response relationship (<i>P</i>(trend)<0.01). The AUC values for ORQ, METS-IR, and METS-VF were 0.937, 0.882, and 0.924, respectively. <b>Conclusion:</b> Occupational stress, METS-IR, and METS-VF exhibit complex interactions with CVD risk in petroleum industry Homo sapiens, increasing disease risk and demonstrating strong predictive capability for incid","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"44 2","pages":"111-117"},"PeriodicalIF":0.0,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147285394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-20DOI: 10.3760/cma.j.cn121094-20241029-00494
J N Li, Z Y Zhang, Y J Wang, Y T Zhang, W X Wang, Y S Zhang
<p><p><b>Objective:</b> To explore the role of hippocampal ferroptosis on nerve impairment of hypertensive mice following lead exposure, and to further explore the role of malic enzyme 1 (ME1) on hippocampal ferroptosis of hypertensive mice following lead exposure. <b>Methods:</b> In January 2024, 62 SPF-grode male C57 mice were selected, among which 32 mice were intraperitoneally injected with angiotensin Ⅱ (AngⅡ, 0.5 mg/kg) for 7 consecutive days to establish the hypertensive mice model. Then, hypertensive mice were randomly divided into hypertension group and Pb+hypertension group, and non-hypertensive mice were randomly divided into control group and Pb group, with 15 mice in each group. Mice in the hypertension group and the Pb+hypertension group were intraperitoneally injected with AngⅡ (0.5 mg/kg) once every two days, and the other two groups were intraperitoneally injected with equal amount of normal saline. Mice in the Pb group and the Pb+hypertension group were given 250 mg/L lead acetate solution, and the other two groups were given the drinking water for 8 weeks. Morris water maze test was applied to detect the cognitive function of mice. Western blotting was used to detect the expression of soulte corrier family 7 member A11 (SLC7A11), glutathione peroxidase 4 (GPX4) and ME1 protein. The contents of Fe(2+), malodialdehyde (MDA) and glutathione (GSH) were measured by corresponding assay kits. The HT22 survival rate was detected by CCK-8 assay. Plasmid transfection technique was used to overexpress ME1 gene in HT22 cells. To construct the ME1-overexpressing HT22 cell model, plasmid transfection was performed. Following verification of transfection efficiency with qPCR, ferroptosis was evaluated in all cell groups after toxicant exposure. Analysis of variance was used for comparisons among group, and the LSD-<i>t</i> test was used for pairwise comparisons. <b>Results:</b> Compared with the control group, the mice in Pb group and hypertension group showed significantly lower escape latency and fewer platform crossings (<i>P</i><0.05). Moreover, the Pb+hypertension group exhibited further significant reductions in these measures compared to either the mice in Pb group or hypertension groupalone (<i>P</i><0.05). The contents of Fe(2+) and MDA in hippocampus of Pb+hypertension group were significantly higher than that of hypertension group and Pb group (<i>P</i><0.05). Meanwhile, the content of GSH and the expression levels of SLC7A11 and GPX4 protein were significantly decreased compared with that of hypertension group and Pb group (<i>P</i><0.05). The exposure of lead and AngⅡ can aggravate the ferroptosis of HT22 cells. At the same time, the treatment of Fer-1 can increased cell survival rate caused by the exposure of lead and AngⅡ (<i>P</i><0.05). ME1 protein expression decreased in the hippocampal tissue of mice in Pb+hypertension group and HT22 cells. Overexpression of the ME1 gene rescues ferroptosis in HT22 cells exposed to lead and
{"title":"[The role of malic enzyme 1 regulating ferroptosis on nerve impairment of hypertensive mice following lead exposure].","authors":"J N Li, Z Y Zhang, Y J Wang, Y T Zhang, W X Wang, Y S Zhang","doi":"10.3760/cma.j.cn121094-20241029-00494","DOIUrl":"https://doi.org/10.3760/cma.j.cn121094-20241029-00494","url":null,"abstract":"<p><p><b>Objective:</b> To explore the role of hippocampal ferroptosis on nerve impairment of hypertensive mice following lead exposure, and to further explore the role of malic enzyme 1 (ME1) on hippocampal ferroptosis of hypertensive mice following lead exposure. <b>Methods:</b> In January 2024, 62 SPF-grode male C57 mice were selected, among which 32 mice were intraperitoneally injected with angiotensin Ⅱ (AngⅡ, 0.5 mg/kg) for 7 consecutive days to establish the hypertensive mice model. Then, hypertensive mice were randomly divided into hypertension group and Pb+hypertension group, and non-hypertensive mice were randomly divided into control group and Pb group, with 15 mice in each group. Mice in the hypertension group and the Pb+hypertension group were intraperitoneally injected with AngⅡ (0.5 mg/kg) once every two days, and the other two groups were intraperitoneally injected with equal amount of normal saline. Mice in the Pb group and the Pb+hypertension group were given 250 mg/L lead acetate solution, and the other two groups were given the drinking water for 8 weeks. Morris water maze test was applied to detect the cognitive function of mice. Western blotting was used to detect the expression of soulte corrier family 7 member A11 (SLC7A11), glutathione peroxidase 4 (GPX4) and ME1 protein. The contents of Fe(2+), malodialdehyde (MDA) and glutathione (GSH) were measured by corresponding assay kits. The HT22 survival rate was detected by CCK-8 assay. Plasmid transfection technique was used to overexpress ME1 gene in HT22 cells. To construct the ME1-overexpressing HT22 cell model, plasmid transfection was performed. Following verification of transfection efficiency with qPCR, ferroptosis was evaluated in all cell groups after toxicant exposure. Analysis of variance was used for comparisons among group, and the LSD-<i>t</i> test was used for pairwise comparisons. <b>Results:</b> Compared with the control group, the mice in Pb group and hypertension group showed significantly lower escape latency and fewer platform crossings (<i>P</i><0.05). Moreover, the Pb+hypertension group exhibited further significant reductions in these measures compared to either the mice in Pb group or hypertension groupalone (<i>P</i><0.05). The contents of Fe(2+) and MDA in hippocampus of Pb+hypertension group were significantly higher than that of hypertension group and Pb group (<i>P</i><0.05). Meanwhile, the content of GSH and the expression levels of SLC7A11 and GPX4 protein were significantly decreased compared with that of hypertension group and Pb group (<i>P</i><0.05). The exposure of lead and AngⅡ can aggravate the ferroptosis of HT22 cells. At the same time, the treatment of Fer-1 can increased cell survival rate caused by the exposure of lead and AngⅡ (<i>P</i><0.05). ME1 protein expression decreased in the hippocampal tissue of mice in Pb+hypertension group and HT22 cells. Overexpression of the ME1 gene rescues ferroptosis in HT22 cells exposed to lead and","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"44 2","pages":"81-89"},"PeriodicalIF":0.0,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147285367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-20DOI: 10.3760/cma.j.cn121094-20250728-00296
S W Mo, H Zhao, N Jia
This paper summarizes the research progress in automated ergonomic contact risk assessment technology based on the rapid upper limb assessment (RULA) and rapid entire body assessment (REBA) , with a focus on analyzing current status and challenges in data acquisition, transmission and processing, application scenarios, and accuracy validation, as well as providing an outlook on future research directions. The analysis indicates that currently, inertial measurement unit (IMU) , conventional/depth cameras, and infrared motion capture systems are the primary hardware devices, with data processing predominantly relying on computer vision and deep learning algorithms. There are significant variations in the accuracy of system assessments, with Cohen's kappa (κ) ranging from 0.21 to 0.95 and the proportion agreement index (Po) ranging from 0.37 to 0.97. Limited by the constraints of data collection and transmission and the reliability of the system, current research primarily employs semi-automated methods in simulated scenarios. Future studies should aim to develop more reliable hardware solutions, establish unified validation standards, and promote the continuous and holistic assessment application of systems in real-world work scenarios.
{"title":"[Research progress of automated ergonomic assessment methods based on RULA and REBA].","authors":"S W Mo, H Zhao, N Jia","doi":"10.3760/cma.j.cn121094-20250728-00296","DOIUrl":"https://doi.org/10.3760/cma.j.cn121094-20250728-00296","url":null,"abstract":"<p><p>This paper summarizes the research progress in automated ergonomic contact risk assessment technology based on the rapid upper limb assessment (RULA) and rapid entire body assessment (REBA) , with a focus on analyzing current status and challenges in data acquisition, transmission and processing, application scenarios, and accuracy validation, as well as providing an outlook on future research directions. The analysis indicates that currently, inertial measurement unit (IMU) , conventional/depth cameras, and infrared motion capture systems are the primary hardware devices, with data processing predominantly relying on computer vision and deep learning algorithms. There are significant variations in the accuracy of system assessments, with Cohen's kappa (κ) ranging from 0.21 to 0.95 and the proportion agreement index (Po) ranging from 0.37 to 0.97. Limited by the constraints of data collection and transmission and the reliability of the system, current research primarily employs semi-automated methods in simulated scenarios. Future studies should aim to develop more reliable hardware solutions, establish unified validation standards, and promote the continuous and holistic assessment application of systems in real-world work scenarios.</p>","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"44 1","pages":"66-71"},"PeriodicalIF":0.0,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146100604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-20DOI: 10.3760/cma.j.cn121094-20240807-00368
J Y Pan, M M Liu, Q Zeng
Objective: To calculate the occupational exposure limits (OELs) of propylene glycol monomethyl ether (PGME) , and to provide a reference for formulating the OELs of PGME in China. Methods: From June to August 2024, data on the physicochemical properties, toxicological test results (acute, subchronic, chronic toxicity and reproductive and developmental toxicity) , and foreign occupational exposure limits (OELs) of PGME were collected by searching databases such as China National Knowledge Infrastructure (CNKI) and PubMed, as well as the official websites of institutions such as the National Institute for Occupational Safety and Health (NIOSH) and the American Conference of Governmental Industrial Hygienists (ACGIH) . The no observed adverse effect level (NOAEL) from chronic toxicity experiments was used as the point of departure for extrapolation (PoD) , and the OELs of PGME were calculated using the OELs mathematical model, taking into account uncertainty factors such as interspecies differences and individual differences within the population. Results: PGME was a colorless and transparent liquid (relative molecular weight 90.121) , mainly absorbed through the respiratory tract and skin, and had eye and nasal irritation, hepatorenal toxicity, and reproductive and developmental toxicity. Through model calculation, the permissible concentration-time weighted average (PC-TWA) of PGME was 185.5 mg/m(3) (50 ppm) . Conclusion: The PGME PC-TWA calculated based on multi-source data, combined with mathematical models and uncertainty coefficients is scientific and reliable, and can provide a scientific basis for the formulation of PGME OELs in China.
{"title":"[Derivation of occupational exposure limits for propylene glycol monomethyl ether based on mathematical models and uncertainty factors].","authors":"J Y Pan, M M Liu, Q Zeng","doi":"10.3760/cma.j.cn121094-20240807-00368","DOIUrl":"https://doi.org/10.3760/cma.j.cn121094-20240807-00368","url":null,"abstract":"<p><p><b>Objective:</b> To calculate the occupational exposure limits (OELs) of propylene glycol monomethyl ether (PGME) , and to provide a reference for formulating the OELs of PGME in China. <b>Methods:</b> From June to August 2024, data on the physicochemical properties, toxicological test results (acute, subchronic, chronic toxicity and reproductive and developmental toxicity) , and foreign occupational exposure limits (OELs) of PGME were collected by searching databases such as China National Knowledge Infrastructure (CNKI) and PubMed, as well as the official websites of institutions such as the National Institute for Occupational Safety and Health (NIOSH) and the American Conference of Governmental Industrial Hygienists (ACGIH) . The no observed adverse effect level (NOAEL) from chronic toxicity experiments was used as the point of departure for extrapolation (PoD) , and the OELs of PGME were calculated using the OELs mathematical model, taking into account uncertainty factors such as interspecies differences and individual differences within the population. <b>Results:</b> PGME was a colorless and transparent liquid (relative molecular weight 90.121) , mainly absorbed through the respiratory tract and skin, and had eye and nasal irritation, hepatorenal toxicity, and reproductive and developmental toxicity. Through model calculation, the permissible concentration-time weighted average (PC-TWA) of PGME was 185.5 mg/m(3) (50 ppm) . <b>Conclusion:</b> The PGME PC-TWA calculated based on multi-source data, combined with mathematical models and uncertainty coefficients is scientific and reliable, and can provide a scientific basis for the formulation of PGME OELs in China.</p>","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"44 1","pages":"26-30"},"PeriodicalIF":0.0,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146100568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-20DOI: 10.3760/cma.j.cn121094-20250905-00352
G Jia, X Y Yu
{"title":"[\"Artificial intelligence+\" occupational health: current applications and future pathways under the healthy China strategy].","authors":"G Jia, X Y Yu","doi":"10.3760/cma.j.cn121094-20250905-00352","DOIUrl":"https://doi.org/10.3760/cma.j.cn121094-20250905-00352","url":null,"abstract":"","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"44 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146100842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-20DOI: 10.3760/cma.j.cn121094-20240613-00265
X Chen, X X Liu, X Q Li, Y Zhang, Z H Zhao, X Y Zhang
Objective: To investigate the relationship between the fit of dust respirator and the head-face dimensions of dust-exposed workers, thereby facilitating the selection of suitable protective respirator for such personnel. Methods: In July 2023, a total of 300 dust-exposed workers at a construction site were selected as research subjects by cluster sampling. The Artec EVA handheld 3D scanner and its software were used to measure 21 head-face dimensions indices. Each subject underwent fit test with one foldable and one cup-shaped respirator. The relationship between head-face dimensions and respirator fit was analyzed using chi-square tests and multivariate logistic regression. Results: A total of 600 fit tests were conducted among the 300 dust-exposed workers, with an overall pass rate of 23.50% (141/600) . Pass rates differed significantly between respirator types: cup-shaped respirator (36.00%, 108/300) higher than foldable respirator (11.00%, 33/300) , and the difference was statistically significant (χ(2)=52.15, P<0.001) . The overall coverage rate of head-face dimension classification was 75.00% (225/300) . There was a statistically significant difference in the pass rate of fit test for cup-shaped respirator among different classification groups (χ(2)=18.92, P<0.05) . Multivariate logistic regression revealed that body mass index (BMI, OR=1.08, P<0.05) , morphological face length (OR=1.58, P<0.05) , nasal width (OR=2.57, P<0.05) , and respirator shape (OR=5.27, P<0.05) were primary factors influencing respirator fit. Conclusion: The key factors influencing respirator fit include BMI, morphological face length, nasal width, and respirator shape. Occupational groups are advised to undergo fit test before initial use of dust respirator.
{"title":"[Study on the relationship between fit of dust respirator and head-face dimensions of dust-exposed workers in a construction site].","authors":"X Chen, X X Liu, X Q Li, Y Zhang, Z H Zhao, X Y Zhang","doi":"10.3760/cma.j.cn121094-20240613-00265","DOIUrl":"https://doi.org/10.3760/cma.j.cn121094-20240613-00265","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the relationship between the fit of dust respirator and the head-face dimensions of dust-exposed workers, thereby facilitating the selection of suitable protective respirator for such personnel. <b>Methods:</b> In July 2023, a total of 300 dust-exposed workers at a construction site were selected as research subjects by cluster sampling. The Artec EVA handheld 3D scanner and its software were used to measure 21 head-face dimensions indices. Each subject underwent fit test with one foldable and one cup-shaped respirator. The relationship between head-face dimensions and respirator fit was analyzed using chi-square tests and multivariate logistic regression. <b>Results:</b> A total of 600 fit tests were conducted among the 300 dust-exposed workers, with an overall pass rate of 23.50% (141/600) . Pass rates differed significantly between respirator types: cup-shaped respirator (36.00%, 108/300) higher than foldable respirator (11.00%, 33/300) , and the difference was statistically significant (<i>χ</i>(2)=52.15, <i>P</i><0.001) . The overall coverage rate of head-face dimension classification was 75.00% (225/300) . There was a statistically significant difference in the pass rate of fit test for cup-shaped respirator among different classification groups (<i>χ</i>(2)=18.92, <i>P</i><0.05) . Multivariate logistic regression revealed that body mass index (BMI, <i>OR</i>=1.08, <i>P</i><0.05) , morphological face length (<i>OR</i>=1.58, <i>P</i><0.05) , nasal width (<i>OR</i>=2.57, <i>P</i><0.05) , and respirator shape (<i>OR</i>=5.27, <i>P</i><0.05) were primary factors influencing respirator fit. <b>Conclusion:</b> The key factors influencing respirator fit include BMI, morphological face length, nasal width, and respirator shape. Occupational groups are advised to undergo fit test before initial use of dust respirator.</p>","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"44 1","pages":"37-42"},"PeriodicalIF":0.0,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146100687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-20DOI: 10.3760/cma.j.cn121094-20240613-00268
J H Zhou, X J Zhao, S J Yang
Objective: To investigate the clinical efficacy of sintilimab combined with chemotherapy in the treatment of malignant pleural mesothelioma. Methods: A prospective case series study was conducted, selecting 66 patients with malignant pleural mesothelioma from Dayao County admitted to the People's Hospital of Chuxiong Yi Autonomous Prefecture from January 2014 to November 2023. The patients were divided into three groups: chemotherapy group, chemotherapy+sintilimab group, and chemotherapy+bevacizumab group, with 22 cases in each group. After 4 cycles of treatment, the clinical efficacy (objective response rate) , tumor markers (carbohydrate antigen 125) , pleural thickness, and adverse drug reactions were evaluated. Follow-up was continued until February 29, 2024. The progression free survival was recorded. Categorical data were compared between groups using chi-square test, and continuous data were analyzed using analysis of variance. Results: The objective response rates in the chemotherapy+sintilimab group (59.09%, 13/22) and chemotherapy+bevacizumab group (63.64%, 14/22) were significantly higher than those in the chemotherapy group (27.27%, 6/22) (P<0.05) . The progressions free survival in the chemotherapy+sintilimab group and chemotherapy+bevacizumab group [ (232.27±82.52) d, (240.68±70.02) d] was significantly longer than that in the chemotherapy group[ (149.59±67.59) d] (P<0.05) . The differences in carbohydrate antigen 125 levels before and after treatment were higher in the chemotherapy+sintilimab group and chemotherapy+bevacizumab group compared to the chemotherapy group (P<0.05) . After 4 cycles of treatment, the maximum pleural thickness and the sum of the maximum pleural thickness in the three areas of the chest cavity were significantly smaller in the chemotherapy+bevacizumab group compared to the chemotherapy group (P<0.05) . There were no statistically significant differences in the incidence of adverse reactions among the three groups (P>0.05) . Conclusion: Chemotherapy+sintilimab and chemotherapy+bevacizumab are more effective than chemotherapy alone in treating malignant pleural mesothelioma, and can prolong the progression free survival of patients.
{"title":"[Clinical effect analysis of sintilimab combined with chemotherapy in the treatment of malignant pleural mesothelioma].","authors":"J H Zhou, X J Zhao, S J Yang","doi":"10.3760/cma.j.cn121094-20240613-00268","DOIUrl":"https://doi.org/10.3760/cma.j.cn121094-20240613-00268","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the clinical efficacy of sintilimab combined with chemotherapy in the treatment of malignant pleural mesothelioma. <b>Methods:</b> A prospective case series study was conducted, selecting 66 patients with malignant pleural mesothelioma from Dayao County admitted to the People's Hospital of Chuxiong Yi Autonomous Prefecture from January 2014 to November 2023. The patients were divided into three groups: chemotherapy group, chemotherapy+sintilimab group, and chemotherapy+bevacizumab group, with 22 cases in each group. After 4 cycles of treatment, the clinical efficacy (objective response rate) , tumor markers (carbohydrate antigen 125) , pleural thickness, and adverse drug reactions were evaluated. Follow-up was continued until February 29, 2024. The progression free survival was recorded. Categorical data were compared between groups using chi-square test, and continuous data were analyzed using analysis of variance. <b>Results:</b> The objective response rates in the chemotherapy+sintilimab group (59.09%, 13/22) and chemotherapy+bevacizumab group (63.64%, 14/22) were significantly higher than those in the chemotherapy group (27.27%, 6/22) (<i>P</i><0.05) . The progressions free survival in the chemotherapy+sintilimab group and chemotherapy+bevacizumab group [ (232.27±82.52) d, (240.68±70.02) d] was significantly longer than that in the chemotherapy group[ (149.59±67.59) d] (<i>P</i><0.05) . The differences in carbohydrate antigen 125 levels before and after treatment were higher in the chemotherapy+sintilimab group and chemotherapy+bevacizumab group compared to the chemotherapy group (<i>P</i><0.05) . After 4 cycles of treatment, the maximum pleural thickness and the sum of the maximum pleural thickness in the three areas of the chest cavity were significantly smaller in the chemotherapy+bevacizumab group compared to the chemotherapy group (<i>P</i><0.05) . There were no statistically significant differences in the incidence of adverse reactions among the three groups (<i>P</i>>0.05) . <b>Conclusion:</b> Chemotherapy+sintilimab and chemotherapy+bevacizumab are more effective than chemotherapy alone in treating malignant pleural mesothelioma, and can prolong the progression free survival of patients.</p>","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"44 1","pages":"54-58"},"PeriodicalIF":0.0,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146100557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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