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[A brief introduction of the new burnout assessment tool (BAT)]. 【新型职业倦怠评估工具(BAT)简介】。
Q3 Medicine Pub Date : 2025-11-20 DOI: 10.3760/cma.j.cn121094-20240408-00153
J F Yang, Y X Sun, Q Hu, J L Gao, J M Dai

This article briefly introduces the new concept of burnout and the new burnout assessment tool BAT. In the past, the most famous burnout definition was proposed by Maslach and Leiter. The Maslach Burnout Inventory (MBI) developed by Maslach has also been the gold standard for evaluating burnout. With the development of burnout research, the concept of burnout has a certain defect. MBI has also been criticized in conceptual, practical and psychological measurement. It may hinder new research, and urgently needs to improve the concept and evaluation of burnout. Therefore, Schaufeli redefined the concept of burnout, and developed a new burnout assessment tool for groups and individuals based on the new concept of burnout-Burnout Assessment Tool (BAT) . This paper systematically reviews the proposal of the new concept of burnout, the development of the BAT scale and its application at home and abroad, and analyzes the advantages and application prospects of the BAT scale.

本文简要介绍了职业倦怠的新概念和新的职业倦怠评估工具BAT。过去,最著名的倦怠定义是由Maslach和Leiter提出的。马斯拉克开发的马斯拉克职业倦怠量表(MBI)也是评估职业倦怠的金标准。随着职业倦怠研究的深入,职业倦怠的概念出现了一定的缺陷。MBI在概念、实践和心理测量方面也受到了批评。这可能会阻碍新的研究,迫切需要完善职业倦怠的概念和评价。因此,Schaufeli重新定义了倦怠的概念,并基于倦怠-倦怠评估工具(BAT)的新概念开发了一种新的群体和个人的倦怠评估工具。本文系统回顾了职业倦怠新概念的提出、BAT量表的发展及其在国内外的应用,分析了BAT量表的优势和应用前景。
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引用次数: 0
[One case of respiratory failure caused by occupational acute acetonitrile poisoning]. 职业性急性乙腈中毒致呼吸衰竭1例
Q3 Medicine Pub Date : 2025-11-20 DOI: 10.3760/cma.j.cn121094-20240813-00377
R K Shang, H Y Liu, Q X Tian, Y R Liu, X D Jian

This article analyzes the treatment process of a patient with respiratory failure caused by occupational acute acetonitrile poisoning. Due to operational errors, the patient's body was sprayed with a large amount of acetonitrile liquid, leading to the absorption of acetonitrile through the skin and resulting in acute poisoning. The clinical manifestations were nervous system and respiratory system damage, accompanied by severe lactic acidosis. After active comprehensive treatments such as tracheal intubation, mechanical ventilation, continuous renal replacement therapy (CRRT) , and glucocorticoids, the patient basically recovered. The treatment process of this patient indicates that early identification and correct first aid of acetonitrile poisoning are the keys to improving prognosis and can provide a reference for the handling of similar clinical cases.

本文分析了一例职业性急性乙腈中毒致呼吸衰竭的治疗过程。由于操作失误,患者体内喷洒了大量乙腈液体,导致乙腈经皮肤吸收,导致急性中毒。临床表现为神经系统、呼吸系统损害,伴严重乳酸酸中毒。经气管插管、机械通气、持续肾替代治疗(CRRT)、糖皮质激素等积极综合治疗,患者基本康复。该患者的治疗过程表明,乙腈中毒的早期识别和正确急救是改善预后的关键,可为临床类似病例的处理提供参考。
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引用次数: 0
[Research on the characteristics and influencing factors of workplace violence in a specialized hospital and its affiliated medical consortium members]. [某专科医院及其所属医疗联合体成员单位工作场所暴力特征及影响因素研究]。
Q3 Medicine Pub Date : 2025-11-20 DOI: 10.3760/cma.j.cn121094-20241011-00464
X X Fang, M Zhang, Y M Huang, F Y Wang, Y T Tang, C N He

Objective: To investigate the characteristics, influencing factors, consequences, coping strategies, and preventive measures of workplace violence in medical consortiums. Methods: Medical professionals from a specialized hospital in South China and its consortium members (2 primary-level, 1 secondary-level, and 1 tertiary-level hospitals) were surveyed in December 2022 and July 2023. Quantitative research included 1013 participants, while qualitative research involved 35 participants. Workplace violence was assessed using the "National Case Study Tool for Workplace Violence in Healthcare Institutions-Survey Questionnaire", with qualitative analysis conducted through semi-structured interviews. Inter-group comparisons employed chi-square tests or Fisher's exact probability test, with logistic regression models for bivariate analysis. Results: The overall incidence rates of violence, psychological violence, and physical violence in this medical consortium were 31.7% (321/1, 013) , 30.6% (310/1, 013) , and 3.3% (33/1, 013) , respectively. Specifically, the overall violence rates in Level 1, Level 2, and Level 3 hospitals were 22.7% (41/181) , 27.4% (43/157) , and 35.1% (237/675) . The physical violence rates were 1.1% (2/181) , 10.2% (16/157) , and 2.2% (15/675) , respectively. The psychological violence rates stood at 22.7% (41/181) , 24.8% (39/157) , and 34.1% (230/675) . The total violence in tertiary hospitals was significantly higher than that in tertiary hospitals (F=10.10, P=0.002) , and the incidence of psychological violence in tertiary hospitals was significantly higher than that in tertiary hospitals (F(level 1 vs level 3)=8.61, P=0.003; F(level 2 vs level 3)=4.96, P=0.026) , incidence of verbal insults (F(level 1 vs level 3)=8.25, P=0.004; F(level 2 vs level 3)=6.36, P= 0.012) was significantly higher than that of level 1 and level 2 hospitals. The incidence of physical violence in secondary hospitals was significantly higher than that of other two-level hospitals (P<0.001) . Compared with other types of violence, the incidence of verbal insults is highest in hospitals at all levels. Higher anxiety about violence was a risk factor for psychological violence in hospitals at all levels (F(level1 hospital)=15.44, P=0.004; F(level2 hospital)=22.87, P<0.001; F(level3 hospital)=84.12, P<0.001) . Health workers in all three levels of hospitals has a high level of approval of existing workplace violence interventions. The main causes of workplace violence were poor communication between doctors and patients (13.2%) , service attitude problems (12.5%) and patient illness (16.9%) . Conclusion: Workplace violence remains prevalent within this medical consortium. Targeted measures should be implemented based on hospital size, functions, and patient demographics.

目的:探讨医疗联合体工作场所暴力的特点、影响因素、后果、应对策略及预防措施。方法:于2022年12月和2023年7月对华南地区某专科医院及其联盟成员医院(2所基层医院、1所二级医院和1所三级医院)的医务人员进行调查。定量研究包括1013名参与者,而定性研究包括35名参与者。工作场所暴力的评估使用了“全国医疗机构工作场所暴力案例研究工具——调查问卷”,并通过半结构化访谈进行了定性分析。组间比较采用卡方检验或Fisher精确概率检验,双变量分析采用logistic回归模型。结果:该医疗联合体中暴力、心理暴力和肢体暴力的总发生率分别为31.7%(321/1 013)、30.6%(310/1 013)和3.3%(33/1 013)。具体而言,1级、2级和3级医院的总体暴力发生率分别为22.7%(41/181)、27.4%(43/157)和35.1%(237/675)。肢体暴力发生率分别为1.1%(2/181)、10.2%(16/157)和2.2%(15/675)。心理暴力发生率分别为22.7%(41/181)、24.8%(39/157)和34.1%(230/675)。三级医院的暴力总发生率显著高于三级医院(F=10.10, P=0.002),心理暴力发生率显著高于三级医院(F(一级vs三级)=8.61,P=0.003;F(水平2 vs水平3)=4.96,P=0.026),言语侮辱发生率(F(水平1 vs水平3)=8.25,P=0.004;F(2级vs 3级)=6.36,P= 0.012)显著高于1级和2级医院。二级医院的身体暴力发生率显著高于其他二级医院(PF(一级医院)=15.44,P=0.004;F(二级医院)=22.87,PF(三级医院)=84.12,结论:工作场所暴力在该医疗联合体中仍然普遍存在。应根据医院规模、功能和患者人口统计数据实施有针对性的措施。
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引用次数: 0
[Analysis of medical behavior and influencing factors of pneumoconiosis patients in primary rehabilitation stations]. 基层康复站尘肺患者医疗行为及影响因素分析
Q3 Medicine Pub Date : 2025-11-20 DOI: 10.3760/cma.j.cn121094-20240701-00290
H J Wang, G L Zhang, E X Li, X P Lyu, H Q Wang

Objective: To study investigates the current healthcare-seeking status of patients with pneumoconiosis at grassroots rehabilitation stations in Henan Province, analyzes their healthcare-seeking behaviors and influencing factors, and provides references for formulating relevant rehabilitation treatment and health management policies. Methods: In July 2024, a total of 492 cases of pneumoconiosis patients registered at 7 grassroots pneumoconiosis rehabilitation stations from July to December 2021 were selected. The "Healthcare-Seeking Behavior and Influencing Factors of Pneumoconiosis Patients" questionnaire was used to collect information through a combination of rehabilitation station consultations and household interviews. Data on medical insurance type, whether the employer had purchased work-related injury insurance, patient condition characteristics (years of dust exposure, pneumoconiosis stage, patient condition score) , and reasons for not visiting rehabilitation stations were gathered and statistically analyzed. Univariate analysis was conducted using the chi-square test and logistic regression analysis was used to identify the influencing factors of patients' medical-seeking behavior. Results: A total of 492 pneumoconiosis patients were registered in basic rehabilitation stations in Henan Province. Among them, 204 cases (41.5%) went to the rehabilitation station, In the past year, 288 cases (58.5%) did not visit. Patients with pneumoconiosis who have no income, whose employer has purchased work-related injury insurance, whose pneumoconiosis type is silicosis, and whose disease score is 15-20 points have a high rate of visits to rehabilitation stations (OR=8.35, 95%CI: 4.40-15.84; OR=13.89, 95%CI: 7.69-25.08; OR=3.20, 95%CI: 1.18-8.68; OR=5.18, 95%CI: 2.04-13.14) . The top five reasons for the analysis of not visiting were: the self-induction symptoms lighter (58.7%, 169/288) , online consultation or telephone follow-up (17.0%, 49/288) , buying medicine in a drugstore (14.6%, 42/288) , thinking of seeing a doctor is useless, can not be cured (6.9%, 20/288) , medical expenses are high and cannot be reimbursed (6.3%, 18/288) . Conclusion: Economically disadvantaged silicosis patients with work-related injury insurance and severe conditions prefer seeking treatment at nearby rehabilitation stations. The main reasons for reluctance to seek medical care are low treatment demand and concerns over high costs. Greater attention should be paid to the demand of pneumoconiosis patients for "Internet+healthcare" services at grassroots-level rehabilitation stations.

目的:了解河南省基层康复站尘肺患者的就医现状,分析其就医行为及影响因素,为制定相关康复治疗和健康管理政策提供参考。方法:选取2024年7月至2021年7月在7个基层尘肺康复站登记的492例尘肺患者。采用“尘肺患者就诊行为及影响因素”问卷,采用康复站咨询与入户访谈相结合的方式收集信息。收集医疗保险类型、雇主是否购买工伤保险、患者病情特征(粉尘暴露年限、尘肺分期、患者病情评分)、不去康复站的原因等数据进行统计分析。采用卡方检验进行单因素分析,logistic回归分析确定患者就诊行为的影响因素。结果:河南省基础康复站共登记尘肺患者492例。其中去康复站204例(41.5%),近一年内未去康复站288例(58.5%)。无收入、雇主购买工伤保险、尘肺类型为矽肺、疾病评分在15 ~ 20分的尘肺患者到康复站就诊的比例较高(OR=8.35, 95%CI: 4.40 ~ 15.84; OR=13.89, 95%CI: 7.69 ~ 25.08; OR=3.20, 95%CI: 1.18 ~ 8.68; OR=5.18, 95%CI: 2.04 ~ 13.14)。不去就诊的原因分析前5位分别为:自感症状较轻(58.7%,169/288)、网上咨询或电话随访(17.0%,49/288)、在药店买药(14.6%,42/288)、认为看病没用、治不好(6.9%,20/288)、医疗费用高且无法报销(6.3%,18/288)。结论:经济困难且有工伤保险且病情严重的矽肺患者倾向于就近到康复站治疗。不愿就医的主要原因是治疗需求低和担心费用高。应更加重视尘肺患者对基层康复站“互联网+医疗”服务的需求。
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引用次数: 0
[One case of VV-ECMO treatment for dimethyl sulfate poisoning]. VV-ECMO治疗硫酸二甲酯中毒1例
Q3 Medicine Pub Date : 2025-11-20 DOI: 10.3760/cma.j.cn121094-20240608-00258
D Q Zhang, M L Tong, Y Yuan, L F Guo

This paper analyzes the treatment process of a patient who developed severe acute respiratory distress syndrome (ARDS) following a chemical leak of dimethyl sulfate caused by factory operational error in February 2023, and explores the efficacy of extracorporeal membrane oxygenation (ECMO) in patient management. The patient developed severe respiratory symptoms five hours after chemical exposure and received sequential treatment with nasal high-flow oxygen therapy and invasive mechanical ventilation upon admission. When the oxygenation index dropped below 100 mmHg, veno-venous (VV) ECMO was initiated alongside 12-hour daily prone position ventilation to improve oxygenation and lung compliance. The patient recovered and was discharged following treatment. For patients with dimethyl sulfate poisoning complicated by severe ARDS, early implementation of VV-ECMO significantly improves treatment outcomes and prognosis.

本文分析了2023年2月因工厂操作失误导致硫酸二甲酯化学品泄漏后发生严重急性呼吸窘迫综合征(ARDS)患者的治疗过程,并探讨了体外膜氧合(ECMO)在患者管理中的疗效。患者在接触化学物质5小时后出现严重呼吸道症状,入院后接受鼻腔高流量吸氧和有创机械通气序贯治疗。当氧合指数低于100 mmHg时,开始静脉-静脉(VV) ECMO,同时每天12小时俯卧位通气,以改善氧合和肺顺应性。患者经治疗后痊愈出院。对于硫酸二甲酯中毒合并严重ARDS患者,早期实施VV-ECMO可显著改善治疗效果和预后。
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引用次数: 0
[Moderating effect of social support on the influence of occupational stress on job burnout among medical staff]. 社会支持对医务人员职业压力对工作倦怠的调节作用
Q3 Medicine Pub Date : 2025-11-20 DOI: 10.3760/cma.j.cn121094-20240923-00439
J H Li, J Chen, S J Yang

Objective: To explore the moderating effect of social support on the effect of occupational stress affecting job burnout, and to provide a theoretical basis for effectively reducing job burnout of medical workers. Methods: In April 2021, a cluster sampling method was adopted. Two units were randomly selected from the tertiary, secondary and primary medical institutions in Shanghai to carry out the survey. The survey was conducted by distributing electronic questionnaires online, and a total of 1963 valid questionnaires were collected. The questionnaire employed Maslach Burnout Inventory-General Survey (MBI-GS) to measure job burnout, and Job Content Questionnaire to measure occupational stress and social support. The questionnaire also collected demographic characteristics and work-related information. Mann-Whitney U test and Kruskal-Wallis H test were used for one-way analysis to test whether there was any difference in the distribution of occupational stress, job burnout, and social support on different demographic characteristics. Spearman's rank correlation coefficient was used to analyze the correlation between occupational stress, job burnout, and social support. Bootstrap method was used to analyze the moderating effect of social support on occupational stress affecting job burnout. Results: The occupational stress score was 1.232 (1.039, 1.530) , the job burnout score was 2.480 (1.560, 3.240) , and the social support score was 3.500 (3.125, 4.000) . Occupational stress, job burnout and social support were distributed differently on sex, job position, hospital level, monthly income, daily working hours, break duration per shift, and break duration between shifts (P<0.05) . Occupational stress was positively associated with job burnout (r(s)=0.49, P<0.001) , and social support was negatively associated with both occupational stress (r(s)=-0.44, P<0.001) and job burnout (r(s)=-0.48, P<0.001) . Social support played a moderating role in the influence of occupational stress on job burnout (B=0.321, 95%CI: 0.216~0.426) . Conclusion: The problem of job burnout is more prominent among medical workers. In the context of enhanced social support, improving job stress condition can lead to a greater decrease in job burnout.

目的:探讨社会支持对职业压力对工作倦怠的调节作用,为有效降低医务工作者的工作倦怠提供理论依据。方法:于2021年4月采用整群抽样方法。在上海市三级、二级和基层医疗机构中随机抽取两个单位进行调查。本次调查采用在线发放电子问卷的方式,共回收有效问卷1963份。问卷采用Maslach职业倦怠量表(MBI-GS)测量工作倦怠,采用《工作内容问卷》测量职业压力和社会支持。调查问卷还收集了人口统计特征和工作相关信息。采用Mann-Whitney U检验和Kruskal-Wallis H检验进行单向分析,检验职业压力、工作倦怠和社会支持在不同人口统计学特征上的分布是否存在差异。采用Spearman等级相关系数分析职业压力、工作倦怠与社会支持的相关关系。运用Bootstrap方法分析社会支持对职业压力对工作倦怠的调节作用。结果:职业压力得分为1.232(1.039,1.530)分,工作倦怠得分为2.480(1.560,3.240)分,社会支持得分为3.500(3.125,4.000)分。职业压力、工作倦怠和社会支持在性别、岗位、医院级别、月收入、日工作时间、每班休息时间和轮班间休息时间上存在差异(Pr(s)=0.49, Pr(s)=-0.44, Pr(s)=-0.48, PB=0.321, 95%CI: 0.216~0.426)。结论:医务工作者工作倦怠问题较为突出。在社会支持增强的背景下,工作压力状况的改善能显著降低工作倦怠。
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引用次数: 0
[Correlation between CT fibrosis score and pulmonary function in artificial stone-associated silicosis]. [人工石相关性矽肺CT纤维化评分与肺功能的相关性]。
Q3 Medicine Pub Date : 2025-11-20 DOI: 10.3760/cma.j.cn121094-20250220-00069
L Liu, L M Huang, H X Tian, L Mao

Objective: To explore the method of CT quantitative evaluation of silicosis fibrosis in artificial stone and analyze its correlation with the stage of chest X-ray and lung function impairment. Methods: The clinical data of 142 patients with artificial stone silicosis who were treated at Shanghai Pulmonary Hospital from January 2018 to December 2022 were collected. These patients were diagnosed based on GBZ 70-2015 Diagnosis of Occupational Pneumoconiosis and underwent chest X-rays, chest CT scans, and lung function tests within a two-month period. The chest CT scoring method is based on the CT characteristics of silicosis, including ground-glass shadows, small nodule shadows, point-line shadows/cord-line shadows, emphysema/pulmonary bullae and patch shadows/mass shadows, with a scoring range of 0 to 25 points. Lung function indicators included FVC, FEV(1) and DLco. For inter-group comparisons of normally distributed quantitative data, one-way ANOVA was employed with LSD post-hoc test for multiple comparisons. Chi-square test was used for multi-group ratio comparisons. Kruskal-Wallis H test was applied to non-normally distributed quantitative data, followed by LSD post-hoc test. Spearman's rank correlation was used to analyze the relationship between pulmonary function indicators and CT fibrosis scores, Trend test was conducted using the Pearson test. Results: As the silicosis stage progressed, both the CT fibrosis score (R=0.87, P(trend)<0.001) and the degree of lung function impairment (FVC: R=-0.41, P(trend)<0.001; FEV(1): R=-0.52, P(trend)<0.001) ; DLco: R=-0.38, P(trend)<0.001) showed an increasing trend. The CT fibrosis Score demonstrated a strong positive correlation with silicosis stage (r(s)=0.85, P(trend)<0.001) and a moderate negative correlation with FVC, FEV(1), and DLco (r(s)=-0.48, -0.56, and -0.45, respectively, with all P<0.05) . Over an average follow-up period of 14 months, it was observed that changes in the CT score had a strong to moderate negative correlation with variations in FVC and FEV(1) (r(s)=-0.63 and -0.52, P<0.05) . Additionally, there was a moderate negative correlation between ground glass opacity and DLco (r(s)=-0.52, P<0.001) . Conclusion: The CT fibrosis score not only reflects pathological changes associated with artificial stone-related silicosis but also provides a more precise representation of lung function injury.

目的:探讨人工结石矽肺纤维化的CT定量评价方法,并分析其与胸片分期及肺功能损害的相关性。方法:收集2018年1月至2022年12月上海肺科医院收治的142例人工石性矽肺患者的临床资料。这些患者根据GBZ 70-2015《职业性尘肺病诊断》进行诊断,并在两个月内进行胸部x光片、胸部CT扫描和肺功能检查。胸部CT评分方法基于矽肺的CT特征,包括磨玻璃影、小结节影、点线影/索线影、肺气肿/肺大泡影、斑块影/团块影,评分范围为0 ~ 25分。肺功能指标包括FVC、FEV(1)、DLco。正态分布定量资料组间比较采用单因素方差分析,多组比较采用LSD事后检验。多组比值比较采用卡方检验。非正态分布定量资料采用Kruskal-Wallis H检验,再进行LSD事后检验。采用Spearman秩相关分析肺功能指标与CT纤维化评分的关系,采用Pearson检验进行趋势检验。结果:随着矽肺分期的进展,CT纤维化评分(R=0.87, P(趋势)R=-0.41, P(趋势)R=-0.52, P(趋势)R=-0.38, P(趋势)R (s)=0.85, P(趋势)R (s)=-0.48, -0.56, -0.45, Pr(s)均=-0.63和-0.52,Pr(s)=-0.52, P)结论:CT纤维化评分不仅能反映人工石相关性矽肺的病理改变,还能更准确地反映肺功能损伤。
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引用次数: 0
[Determination of glyphosate and glufosinate in plasma samples by solid-phase extraction coupled with liquid chromatography-tandem mass spectrometry]. [固相萃取-液相色谱-串联质谱法测定血浆样品中的草甘膦和草膦]。
Q3 Medicine Pub Date : 2025-11-20 DOI: 10.3760/cma.j.cn121094-20240826-00400
S D Pan, Q L Qiu, L Wang

Objective: To establish a rapid method for the determination of glyphosate and glufosinate residues in plasma samples by solid-phase extraction-liquid chromatography-tandem mass spectrometry (SPE-LC-MS/MS) . Methods: In March 2024, plasma samples were extracted and protein precipitated with methanol and purified using a weak cation exchange (WCX) SPE cartridge. Then the samples were separated on a Dikma Polyamino HILIC column (150 mm×2.0 mm, 5 μm) with a gradient elution of 1.0 mmol/L ammonium fluoride aqueous solution (pH=11) and acetonitrile as mobile phases. Analysis was performed using an electrospray ionization source (ESI) in multiple reaction monitoring (MRM) mode with internal standard quantification. The method's linearity, detection limits, spiked recovery and precision were then evaluated. Results: Glyphosate and glufosinate exhibited good linearity in the concentration range of 1.0-200.0 μg/L, with correlation coefficients of 0.9986-0.9992. The limits of detection (LODs) of glyphosate and glufosinate were 0.5 and 1.0 μg/L, respectively. At low, medium and high spiked concentrations, the spiked recovery rates and precision for glyphosate and glufosinate in plasma ranged from 92.5% to 113.2% and 3.01% to 11.23%, respectively. Conclusion: The SPE-LC-MS/MS method is simple, rapid, sensitive and accurate, and is suitable for the qualitative and quantitative analysis of glyphosate and glufosinate in plasma from poisoned patients.

目的:建立固相萃取-液相色谱-串联质谱(SPE-LC-MS/MS)快速测定血浆样品中草甘膦和草铵膦残留量的方法。方法:于2024年3月提取血浆样品,用甲醇沉淀蛋白质,用弱阳离子交换(WCX)固相萃取(SPE)试剂盒纯化。采用Dikma Polyamino HILIC色谱柱(150 mm×2.0 mm, 5 μm),以1.0 mmol/L氟化铵水溶液(pH=11)和乙腈为流动相梯度洗脱。采用电喷雾电离源(ESI)进行多反应监测(MRM)模式,内标定量分析。对方法的线性度、检出限、加标回收率和精密度进行了评价。结果:草甘膦与草甘膦在1.0 ~ 200.0 μg/L范围内线性良好,相关系数为0.9986 ~ 0.9992;草甘膦和草甘膦的检出限分别为0.5和1.0 μg/L。在低、中、高加标浓度下,血浆中草甘膦和草铵膦的加标回收率和精密度分别为92.5% ~ 113.2%和3.01% ~ 11.23%。结论:SPE-LC-MS/MS方法简便、快速、灵敏、准确,适用于中毒患者血浆中草甘膦和草铵膦的定性和定量分析。
{"title":"[Determination of glyphosate and glufosinate in plasma samples by solid-phase extraction coupled with liquid chromatography-tandem mass spectrometry].","authors":"S D Pan, Q L Qiu, L Wang","doi":"10.3760/cma.j.cn121094-20240826-00400","DOIUrl":"https://doi.org/10.3760/cma.j.cn121094-20240826-00400","url":null,"abstract":"<p><p><b>Objective:</b> To establish a rapid method for the determination of glyphosate and glufosinate residues in plasma samples by solid-phase extraction-liquid chromatography-tandem mass spectrometry (SPE-LC-MS/MS) . <b>Methods:</b> In March 2024, plasma samples were extracted and protein precipitated with methanol and purified using a weak cation exchange (WCX) SPE cartridge. Then the samples were separated on a Dikma Polyamino HILIC column (150 mm×2.0 mm, 5 μm) with a gradient elution of 1.0 mmol/L ammonium fluoride aqueous solution (pH=11) and acetonitrile as mobile phases. Analysis was performed using an electrospray ionization source (ESI) in multiple reaction monitoring (MRM) mode with internal standard quantification. The method's linearity, detection limits, spiked recovery and precision were then evaluated. <b>Results:</b> Glyphosate and glufosinate exhibited good linearity in the concentration range of 1.0-200.0 μg/L, with correlation coefficients of 0.9986-0.9992. The limits of detection (LODs) of glyphosate and glufosinate were 0.5 and 1.0 μg/L, respectively. At low, medium and high spiked concentrations, the spiked recovery rates and precision for glyphosate and glufosinate in plasma ranged from 92.5% to 113.2% and 3.01% to 11.23%, respectively. <b>Conclusion:</b> The SPE-LC-MS/MS method is simple, rapid, sensitive and accurate, and is suitable for the qualitative and quantitative analysis of glyphosate and glufosinate in plasma from poisoned patients.</p>","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"43 11","pages":"865-868"},"PeriodicalIF":0.0,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145670077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Determination of Bismuth and Bismuth Telluride in the air of working place by Ultrawave digestion with atomic-fluorescence spectrometry]. [工作场所空气中铋和碲化铋的紫外消解原子荧光光谱法测定]。
Q3 Medicine Pub Date : 2025-11-20 DOI: 10.3760/cma.j.cn121094-20240528-00241
Q Ji, J H Yuan, J Cao, L Y Wang, H Wang

Objective: To establish an atomic fluorescence detection method for bismuth and bismuth telluride (Bi(2)Te(3)) in the air of workplaces. Methods: In March 2024, the acetate-fiber filter material was digested by ultrawave and detected by atomic fluorescence spectrometry to obtain the content of bismuth and Bi(2)Te(3) in the air of the workplace. Results: The correlation coefficients of standard curve were above 0.9990, The detection limit of bismuth was 0.02 μg/L, the minimum detection concentration was 0.02 μg/m(3), the minimum quantitation concentration was 0.06 μg/m(3), the minimum detection concentration and the minimum quantitation concentration of Bi(2)Te(3) was 0.03 μg/m(3) and 0.09 μg/m(3) respectively. The digestion efficiency ranged from 98.6% to 102 %, the RSDs of intra-batch and inter-batch were below 1.3% and 4.0% respectively. The samples were stable within 7 days, and interference elements of 1.0 mg/L (Ag, Al, As, B, Ba, Be, Cd, Co, Cr, Cs, Cu, Fe, Ga, Li, Mg, Mn, Mo, Ni, Pb, Rb, Sb, Se, Sn, Sr, Ti, Tl, V, Zn, Zr) do not affect the detection of bismuth. Conclusion: This method is simple, fast, accurate, and highly sensitive, and can meet the requirements of the determination of bismuth and bismuth telluride in the air of working place.

目的:建立工作场所空气中铋和碲化铋(Bi(2)Te(3))的原子荧光检测方法。方法:于2024年3月对醋酸酯纤维滤料进行超声波消解,原子荧光光谱法测定工作场所空气中铋和Bi(2)Te(3)的含量。结果:标准曲线相关系数均在0.9990以上,铋的检出限为0.02 μg/L,最低检测浓度为0.02 μg/m(3),最低定量浓度为0.06 μg/m(3), Bi(2)Te(3)的最低检测浓度和最低定量浓度分别为0.03 μg/m(3)和0.09 μg/m(3)。消化效率为98.6% ~ 102%,批内rsd < 1.3%,批间rsd < 4.0%。样品在7天内稳定,1.0 mg/L的干扰元素(Ag、Al、As、B、Ba、Be、Cd、Co、Cr、Cs、Cu、Fe、Ga、Li、mg、Mn、Mo、Ni、Pb、Rb、Sb、Se、Sn、Sr、Ti、Tl、V、Zn、Zr)不影响铋的检测。结论:该方法简便、快速、准确、灵敏度高,可满足工作场所空气中铋和碲化铋的测定要求。
{"title":"[Determination of Bismuth and Bismuth Telluride in the air of working place by Ultrawave digestion with atomic-fluorescence spectrometry].","authors":"Q Ji, J H Yuan, J Cao, L Y Wang, H Wang","doi":"10.3760/cma.j.cn121094-20240528-00241","DOIUrl":"https://doi.org/10.3760/cma.j.cn121094-20240528-00241","url":null,"abstract":"<p><p><b>Objective:</b> To establish an atomic fluorescence detection method for bismuth and bismuth telluride (Bi(2)Te(3)) in the air of workplaces. <b>Methods:</b> In March 2024, the acetate-fiber filter material was digested by ultrawave and detected by atomic fluorescence spectrometry to obtain the content of bismuth and Bi(2)Te(3) in the air of the workplace. <b>Results:</b> The correlation coefficients of standard curve were above 0.9990, The detection limit of bismuth was 0.02 μg/L, the minimum detection concentration was 0.02 μg/m(3), the minimum quantitation concentration was 0.06 μg/m(3), the minimum detection concentration and the minimum quantitation concentration of Bi(2)Te(3) was 0.03 μg/m(3) and 0.09 μg/m(3) respectively. The digestion efficiency ranged from 98.6% to 102 %, the RSDs of intra-batch and inter-batch were below 1.3% and 4.0% respectively. The samples were stable within 7 days, and interference elements of 1.0 mg/L (Ag, Al, As, B, Ba, Be, Cd, Co, Cr, Cs, Cu, Fe, Ga, Li, Mg, Mn, Mo, Ni, Pb, Rb, Sb, Se, Sn, Sr, Ti, Tl, V, Zn, Zr) do not affect the detection of bismuth. <b>Conclusion:</b> This method is simple, fast, accurate, and highly sensitive, and can meet the requirements of the determination of bismuth and bismuth telluride in the air of working place.</p>","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"43 11","pages":"869-872"},"PeriodicalIF":0.0,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145670015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Analysis of the impact of work engagement on mental health of full-time and part-time student management staff in Xinjiang Universities]. 工作投入对新疆高校专兼职学生管理人员心理健康的影响分析
Q3 Medicine Pub Date : 2025-11-20 DOI: 10.3760/cma.j.cn121094-20240718-00320
J Liu, X Y Gao

Objective: To explore the relationship between work engagement, job burnout, and mental health among full-time and part-time student management staff in universities in Xinjiang, and to provide a scientific basis for developing differentiated mental health intervention measures. Methods: By using the method of cluster random sampling, 1267 student management staff from five universities in Urumqi were selected as the research subjects from March 2020 to December 2021. Data collection was conducted using the Utrecht Work Engagement Scale (UWES-9) , the Maslach Burnout Inventory-General Survey (MBI-GS) , and the Symptom Checklist-90 (SCL-90) . Spearman rank correlation analysis was used to explore the relationship among work engagement, job burnout and mental health. Multivariate logistic regression was adopted to analyze the influencing factors of mental health, and the mediating effect of job burnout was analyzed through the mediating effect test. Results: The detection proportions of job burnout and psychological disorders were 80.5% (525/652) and 38.5% (251/652) among full-time personnel, and 75.3% (463/615) and 30.2% (186/615) among part-time personnel, respectively. Spearman rank correlation analysis showed that work engagement was negatively correlated with psychological disorders (r(s)=-0.720, -0.760, P<0.001) and job burnout (r(s)=-0.776, -0.700, P<0.001) in both full-time and part-time personnel, while job burnout was positively correlated with psychological disorders (r(s)=0.804, 0.718, P<0.001) . Multivariate logistic regression analysis indicated that high work engagement (full-time: OR=0.05, 95%CI: 0.02-0.18; part-time: OR=0.02, 95%CI: 0.01-0.04) was a protective factor for mental health (P<0.001) , whereas job burnout (full-time: OR=10.85, 95%CI: 3.50-33.58; part-time: OR=3.71, 95%CI: 1.76-7.76) was a risk factor for mental health (P<0.001) . Mediating effect tests demonstrated that job burnout played a partial mediating effect between work engagement and mental health, with mediating effect proportions of 57.3% and 27.9% for full-time and part-time personnel, respectively. Conclusion: The detection proportions of job burnout and psychological disorders among full-time and part-time student management staff in Xinjiang universities are relatively high, and job burnout acts as a mediating variable between work engagement and mental health. Universities should enhance the work engagement level of student management staff to prevent and alleviate job burnout, and thereby improving their mental health status.

目的:探讨新疆地区高校专兼职学生管理人员工作投入、工作倦怠与心理健康的关系,为制定差别化的心理健康干预措施提供科学依据。方法:采用整群随机抽样的方法,于2020年3月至2021年12月选取乌鲁木齐市5所高校的1267名学生管理人员作为研究对象。数据收集采用乌得勒支工作投入量表(UWES-9)、Maslach职业倦怠量表(MBI-GS)和症状检查表-90 (SCL-90)进行。采用Spearman秩相关分析探讨工作投入、工作倦怠与心理健康的关系。采用多因素logistic回归分析心理健康的影响因素,通过中介效应检验分析工作倦怠的中介作用。结果:专职人员工作倦怠和心理障碍检出率分别为80.5%(525/652)和38.5%(251/652),兼职人员分别为75.3%(463/615)和30.2%(186/615)。Spearman秩相关分析显示,工作投入与心理障碍呈负相关(r(s)=-0.720、-0.760,Pr(s)=-0.776、-0.700,Pr(s)=0.804、0.718,POR=0.05, 95%CI: 0.02 ~ 0.18;非全日制:OR=0.02, 95%CI: 0.01 ~ 0.04)是心理健康的保护因素(POR=10.85, 95%CI: 3.50 ~ 33.58;非全日制:OR=3.71, 95%CI: 1.76 ~ 7.76)是心理健康的危险因素(pp结论:新疆高校专兼职学生管理人员工作倦怠和心理障碍检出率较高,工作倦怠是工作投入与心理健康之间的中介变量。高校应提高学生管理人员的工作敬业度,预防和缓解工作倦怠,从而改善学生管理人员的心理健康状况。
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引用次数: 0
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中华劳动卫生职业病杂志
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