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[Impacts of participation in surgical clinical trial on safety and survival outcomes in patients with right-sided colon cancer]. [参加外科临床试验对右侧结肠癌患者安全性和生存结果的影响]。
Q3 Medicine Pub Date : 2024-09-25 DOI: 10.3760/cma.j.cn441530-20240129-00048
H Q Zhang, G Q Wang, B Wu, G L Lin, H Z Qiu, B Z Niu, J Y Lu, L Xu, X Y Sun, G N Zhang, Y Xiao
<p><p><b>Objective:</b> To explore the impact on safety and prognosis in patients with right-sided colon cancer participating in surgical clinical research. <b>Methods:</b> This retrospective cohort study utilized data from a randomized controlled trial (RELARC study) conducted by the colorectal surgery group at Peking Union Medical College Hospital in which laparoscopic complete mesocolic excision (CME) was compared with D2 radical resection for the management of right-sided colon cancer. The eligibility criteria were age 18-75 years, biopsy-proven colon adenocarcinoma, tumor located between the cecum and right 1/3 of the transverse colon, enhanced chest, abdomen, and pelvic CT scans suggesting tumor stage T2-T4N0M0 or TanyN+ M0, and having undergone radical surgical treatment from January 2016 to December 2019. Exclusion factors included multiple primary colorectal cancers, preoperative stage T1N0 or enlarged central lymph nodes, tumor involving surrounding organs requiring their resection, definite distant metastasis or otherwise unable to undergo R0 resection, history of any other malignant tumors within previous 5 years, intestinal obstruction, perforation, or gastrointestinal bleeding requiring emergency surgery, and assessed as unsuitable for laparoscopic surgery. Patients who had participated in the RELARC study were included in the RELARC group, whereas those who met the inclusion criteria but refused to participate in the RELAEC study were included in the control group. The main indicators studied were the patient's baseline data, surgery and perioperative conditions, pathological characteristics, adjuvant treatment, and postoperative follow-up (including average frequency of follow-up within the first 3 years) and survival (including 3-year disease-free survival rate (DFS) and 3-year overall survival rate (OS). Differences in these indicators between the RELARC and control groups were compared. <b>Results:</b> The study cohort comprised 290 patients, 173 in the RELARC group (RELARC-CME group, 82; RELARC-D2 group, 91) and 117 in the control group (CME control group, 72; D2 control group, 45). There was a significantly higher proportion of overweight patients (BMI ≥24 kg/m<sup>2</sup>) in the RELARC-CME than in the CME control group (67.1% [55/82] vs. 33.3% [24/72], χ<sup>2</sup>=17.469, <i>P</i><0.001). There were no other statistically significant differences in baseline characteristics (all <i>P</i>>0.05). No significant disparities were found between the CME and D2 groups in terms of operation duration, intraoperative blood loss, rate of conversion to open surgery, combined organ resection, intraoperative blood transfusion, or intraoperative complications (all <i>P</i>>0.05). There was a trend toward Clavien-Dindo grade II or higher postoperative complications in the RELARC-CME group (24.4% [20/82]) than in the CME control group (18.1% [13/72]); however, this difference was not statistically significant (χ<sup>2</sup>=0.914, <i>P</i>
目的探讨参与外科临床研究的右侧结肠癌患者对安全性和预后的影响。方法: 采用随机对照试验(RELARC 研究)的数据进行回顾性队列研究:这项回顾性队列研究利用了北京协和医院结直肠外科小组开展的一项随机对照试验(RELARC 研究)的数据,该试验比较了腹腔镜完整结肠系膜切除术(CME)和 D2 根治性切除术治疗右侧结肠癌的效果。入选标准为年龄18-75岁,活检证实为结肠腺癌,肿瘤位于盲肠和横结肠右1/3之间,胸部、腹部和盆腔CT增强扫描提示肿瘤分期为T2-T4N0M0或TanyN+ M0,2016年1月至2019年12月期间接受过根治性手术治疗。排除因素包括:多发性原发性结直肠癌、术前分期T1N0或中央淋巴结肿大、肿瘤累及周围器官需要切除、明确远处转移或因其他原因无法进行R0切除、前5年内有任何其他恶性肿瘤病史、肠梗阻、穿孔或消化道出血需要紧急手术,以及经评估不适合腹腔镜手术。参加过RELARC研究的患者被纳入RELARC组,而符合纳入标准但拒绝参加RELAEC研究的患者被纳入对照组。研究的主要指标包括患者的基线数据、手术和围手术期情况、病理特征、辅助治疗、术后随访(包括前3年的平均随访频率)和生存率(包括3年无病生存率(DFS)和3年总生存率(OS))。比较了 RELARC 组和对照组在这些指标上的差异。研究结果研究队列由 290 名患者组成,其中 RELARC 组 173 人(RELARC-CME 组 82 人;RELARC-D2 组 91 人),对照组 117 人(CME 对照组 72 人;D2 对照组 45 人)。RELARC-CME组超重患者(体重指数≥24 kg/m2)的比例明显高于CME对照组(67.1% [55/82] vs. 33.3% [24/72],χ2=17.469,PP>0.05)。CME组和D2组在手术时间、术中失血量、转为开放手术率、合并器官切除、术中输血和术中并发症等方面没有发现明显差异(均P>0.05)。与CME对照组(18.1% [13/72])相比,RELARC-CME组(24.4% [20/82])的术后并发症呈Clavien-Dindo II级或更高的趋势,但这一差异无统计学意义(χ2=0.914,P=0.339)。同样,这一比例在 RELARC-D2 组(25.3% [23/91])和 D2 对照组(24.4% [11/45],χ2=0.011,P=0.916)之间也没有明显差异。RELARC组术后随访的中位持续时间明显短于相应的对照组。具体来说,RELARC-CME组的中位随访时间为4.5(4.5,4.5)个月,CME对照组为7.2(6.0,9.0)个月(Z=-10.608,PZ=-10.595,PP>0.05)。根据病理分期进行的亚组分析显示,pN0 期的 RELARC-D2 组患者的 3 年 OS 率明显高于 D2 对照组(100% 对 88.9%,P=0.008)。我们发现,其余亚组之间的生存率差异无统计学意义(P>0.05)。结论:这是一项高质量的外科临床试验:密切随访的高质量外科临床试验可实现围手术期的安全性和改善生存结果的趋势。
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引用次数: 0
[Chinese expert consensus on the surgical treatment of right-sided colon cancer (2024 edition)]. [右侧结肠癌外科治疗中国专家共识(2024 年版)]。
Q3 Medicine Pub Date : 2024-09-25 DOI: 10.3760/cma.j.cn441530-20240817-00287

In the past two decades, with the development and application of laparoscopic technique and the promotion of the concept of complete mesocolic excision, significant changes have occurred in the surgical treatment of right-sided colon cancer. The Chinese Society of Colorectal Surgery and Chinese Colorectal Research Consortium (CCRC) Organized national experts in colorectal surgery to form a consensus on 14 key clinical issues related to right hemicolectomy, taking into account the preferences of Chinese doctors and patients as well as the pros and cons of intervention measures, with a view to standardizing the surgical treatment of right colon cancer. The consensus recommendations were focused on three main aspects: (1) surgical anatomy: the key structures and its definitions related to the mesentery and vascular anatomy were clarified. It is recommended that the left side of the superior mesenteric artery be considered the medial boundary for complete mesocolic excision; (2) surgical technique: laparoscopy is recommended as the preferred surgical approach for right-sided colon cancer; (3) surgical principles: D2 lymph node dissection could be considered as the standard of care for right-sided colon cancer. Standard D2 could be considered as routine procedure unless preoperative imaging or intraoperative exploration revealed suspected regional lymph node metastasis. Dissection of infrapyloric lymph node is not recommended unless it is suspected as metastasis. Additionally, consensus recommendations were made regarding the location of vascular ligation, the extent of bowel resection, and anastomosis techniques.

近二十年来,随着腹腔镜技术的发展和应用,以及全系膜切除理念的推广,右半结肠癌的外科治疗发生了重大变化。中华医学会结直肠外科学分会和中国结直肠研究联盟(CCRC)组织全国结直肠外科专家,结合我国医生和患者的偏好以及干预措施的利弊,就右半结肠切除术相关的 14 个关键临床问题形成共识,以期规范右半结肠癌的外科治疗。共识建议主要集中在三个方面:(1)手术解剖:明确了肠系膜和血管解剖相关的关键结构及其定义。建议将肠系膜上动脉左侧作为完整切除肠系膜的内侧边界;(2)手术技术:建议将腹腔镜作为右侧结肠癌的首选手术方法;(3)手术原则:D2 淋巴结清扫术可视为右侧结肠癌的标准治疗方法。除非术前造影或术中探查发现疑似区域淋巴结转移,否则可将标准 D2 作为常规手术。除非怀疑有转移,否则不建议切除幽门下淋巴结。此外,还就血管结扎的位置、肠切除范围和吻合技术提出了共识性建议。
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引用次数: 0
[Comprehensive evaluation of single-anastomosis duodenal-ileal bypass with sleeve gastrectomy in obese patients based on efficacy and nutrition]. [肥胖患者单吻合十二指肠-回肠旁路术联合袖带胃切除术的疗效和营养综合评估]。
Q3 Medicine Pub Date : 2024-09-25 DOI: 10.3760/cma.j.cn441530-20230810-00041
L F Hu, L Wang, S X Li, Y Liu, Z Zhang, M H Xiao, Z H Zhang, Z Q Wei, L Cui, T Jiang
<p><p><b>Objective:</b> To evaluate the 1-year postoperative efficacy and nutritional indicators of single-anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S) in obese patients. <b>Methods:</b> This retrospective observational study included patients with a body mass index (BMI) of ≥40.0 kg/m<sup>2</sup> regardless of other related metabolic diseases and patients with severe type 2 diabetes and a BMI between 27.5 and 40.0 kg/m<sup>2</sup>. The clinical data of 66 obese patients who underwent SADI-S at the Bariatric and Metabolic Surgery Department of China-Japan Union Hospital of Jilin University from November 2018 to May 2022 were collected, including 53 cases of da Vinci robotic surgery and 13 cases of laparoscopic surgery. The patients comprised 38 men and 28 women with a median age of 35 (18-61) years and a mean preoperative BMI of 42.93 ± 6.82 kg/m<sup>2</sup>. A total of 38 patients had type 2 diabetes, and 46 had hyperuricemia, 45 had hypertension, 35 had hyperlipidemia, 12 had hypercholesterolemia, and 12 had a high low-density lipoprotein (LDL) level. The main observation indicators were (1) intraoperative and postoperative conditions; (2) weight loss outcomes, including body weight, BMI, excess body weight loss (%EWL), and total body weight loss (%TWL) at 3, 6, and 12 months after surgery; (3) effects of treatment on metabolic disease; and (4) changes in nutrient indicators. <b>Results:</b> (1) Intraoperative and postoperative conditions: All patients successfully underwent SADI-S with neither conversion to laparotomy nor death. Four (6.1%) patients developed postoperative complications, and all of them recovered and were discharged after conservative or surgical treatment. (2) Weight loss outcomes: %EWL at 3, 6, and 12 months after surgery was 62.07 ± 26.56, 85.93 ± 27.92, and 106.65 ± 29.65, respectively, and %TWL was 22.67 ± 4.94, 32.10 ± 5.18, and 40.56 ± 7.89, respectively. Body weight and BMI 3 to 12 months after surgery were significantly lower than those before surgery (all <i>P</i> < 0.001). (3) Effect of treatment on metabolic disease: 3 to 12 months after surgery, fasting blood sugar, HbA1c, uric acid, systolic blood pressure, diastolic blood pressure, triglycerides, total cholesterol, LDL, and other indicators were significantly lower than those before surgery (all <i>P</i> < 0.05). Twelve months after surgery, the remission rates of diabetes, hyperuricemia, hypertension, hypertriglyceridemia, hypercholesterolemia, and high LDL were 100% (38/38), 65.2% (30/46), 62.2% (28/45), 94.3% (33/35), 100% (12/12), and 100% (12/12), respectively. (4) Changes in nutrient indicators: Compared with the preoperative nutrient levels, the hemoglobin and hematocrit levels were lower at 3 to 12 months after surgery, the total protein level was lower at 6 to 12 months after surgery, the albumin level was lower at 6 months after surgery, and the ferritin level was lower at 3 months after surgery. The differences were statistically
目的评估肥胖患者单吻合十二指肠-回肠旁路袖带胃切除术(SADI-S)术后 1 年的疗效和营养指标。研究方法:这项回顾性观察研究纳入了体重指数(BMI)≥40.0 kg/m2且无其他相关代谢疾病的患者,以及体重指数在 27.5 至 40.0 kg/m2 之间的严重 2 型糖尿病患者。收集了2018年11月至2022年5月在吉林大学中日联谊医院减重与代谢外科接受SADI-S手术的66例肥胖患者的临床资料,其中达芬奇机器人手术53例,腹腔镜手术13例。患者中男性38例,女性28例,中位年龄35(18-61)岁,术前平均体重指数(BMI)为42.93±6.82 kg/m2。共有 38 名患者患有 2 型糖尿病,46 名患者患有高尿酸血症,45 名患者患有高血压,35 名患者患有高脂血症,12 名患者患有高胆固醇血症,12 名患者患有高低密度脂蛋白(LDL)水平。主要观察指标为:(1)术中和术后情况;(2)体重减轻结果,包括术后3、6和12个月的体重、体重指数(BMI)、超重体重减轻率(%EWL)和总体重减轻率(%TWL);(3)治疗对代谢性疾病的影响;(4)营养指标的变化。结果:(1)术中和术后情况:所有患者都成功接受了 SADI-S,既没有转为开腹手术,也没有死亡。4例(6.1%)患者出现术后并发症,经保守或手术治疗后全部康复出院。(2)体重减轻结果:术后3、6和12个月的EWL%分别为(62.07 ± 26.56)、(85.93 ± 27.92)和(106.65 ± 29.65),TWL%分别为(22.67 ± 4.94)、(32.10 ± 5.18)和(40.56 ± 7.89)。术后 3 至 12 个月的体重和 BMI 均明显低于术前(均 P <0.001)。(3)治疗对代谢疾病的影响:术后3至12个月,空腹血糖、HbA1c、尿酸、收缩压、舒张压、甘油三酯、总胆固醇、低密度脂蛋白等指标均明显低于术前(均P<0.05)。术后12个月,糖尿病、高尿酸血症、高血压、高甘油三酯血症、高胆固醇血症和高低密度脂蛋白的缓解率分别为100%(38/38)、65.2%(30/46)、62.2%(28/45)、94.3%(33/35)、100%(12/12)和100%(12/12)。(4) 营养指标的变化:与术前营养水平相比,术后 3 至 12 个月的血红蛋白和血细胞比容水平较低,术后 6 至 12 个月的总蛋白水平较低,术后 6 个月的白蛋白水平较低,术后 3 个月的铁蛋白水平较低。这些差异均有统计学意义(P<0.05)。贫血的发生率为 6.1%(4/66),低白蛋白血症的发生率为 4.5%(3/66),铁蛋白缺乏的发生率为 4.5%(3/66),所有这些症状都在保守治疗后得到改善或恢复正常。术后 12 个月,30(45.5%)名患者出现维生素 A 缺乏症,17(25.8%)名患者出现维生素 E 缺乏症,11(16.7%)名患者出现叶酸缺乏症,2 名患者出现钾缺乏症(3.0%),3(4.5%)名患者出现钙缺乏症,2(3.0%)名患者出现镁缺乏症,9(13.6%)名患者出现铁缺乏症,16(24.2%)名患者出现锌缺乏症。但是,没有出现相关的临床症状。结论SADI-S 对减轻体重和缓解代谢性疾病有非常明显的效果。SADI-S 后的营养缺乏主要涉及维生素 A、维生素 E、锌和叶酸。SADI-S 的长期疗效和安全性仍需进一步跟踪观察。
{"title":"[Comprehensive evaluation of single-anastomosis duodenal-ileal bypass with sleeve gastrectomy in obese patients based on efficacy and nutrition].","authors":"L F Hu, L Wang, S X Li, Y Liu, Z Zhang, M H Xiao, Z H Zhang, Z Q Wei, L Cui, T Jiang","doi":"10.3760/cma.j.cn441530-20230810-00041","DOIUrl":"10.3760/cma.j.cn441530-20230810-00041","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To evaluate the 1-year postoperative efficacy and nutritional indicators of single-anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S) in obese patients. &lt;b&gt;Methods:&lt;/b&gt; This retrospective observational study included patients with a body mass index (BMI) of ≥40.0 kg/m&lt;sup&gt;2&lt;/sup&gt; regardless of other related metabolic diseases and patients with severe type 2 diabetes and a BMI between 27.5 and 40.0 kg/m&lt;sup&gt;2&lt;/sup&gt;. The clinical data of 66 obese patients who underwent SADI-S at the Bariatric and Metabolic Surgery Department of China-Japan Union Hospital of Jilin University from November 2018 to May 2022 were collected, including 53 cases of da Vinci robotic surgery and 13 cases of laparoscopic surgery. The patients comprised 38 men and 28 women with a median age of 35 (18-61) years and a mean preoperative BMI of 42.93 ± 6.82 kg/m&lt;sup&gt;2&lt;/sup&gt;. A total of 38 patients had type 2 diabetes, and 46 had hyperuricemia, 45 had hypertension, 35 had hyperlipidemia, 12 had hypercholesterolemia, and 12 had a high low-density lipoprotein (LDL) level. The main observation indicators were (1) intraoperative and postoperative conditions; (2) weight loss outcomes, including body weight, BMI, excess body weight loss (%EWL), and total body weight loss (%TWL) at 3, 6, and 12 months after surgery; (3) effects of treatment on metabolic disease; and (4) changes in nutrient indicators. &lt;b&gt;Results:&lt;/b&gt; (1) Intraoperative and postoperative conditions: All patients successfully underwent SADI-S with neither conversion to laparotomy nor death. Four (6.1%) patients developed postoperative complications, and all of them recovered and were discharged after conservative or surgical treatment. (2) Weight loss outcomes: %EWL at 3, 6, and 12 months after surgery was 62.07 ± 26.56, 85.93 ± 27.92, and 106.65 ± 29.65, respectively, and %TWL was 22.67 ± 4.94, 32.10 ± 5.18, and 40.56 ± 7.89, respectively. Body weight and BMI 3 to 12 months after surgery were significantly lower than those before surgery (all &lt;i&gt;P&lt;/i&gt; &lt; 0.001). (3) Effect of treatment on metabolic disease: 3 to 12 months after surgery, fasting blood sugar, HbA1c, uric acid, systolic blood pressure, diastolic blood pressure, triglycerides, total cholesterol, LDL, and other indicators were significantly lower than those before surgery (all &lt;i&gt;P&lt;/i&gt; &lt; 0.05). Twelve months after surgery, the remission rates of diabetes, hyperuricemia, hypertension, hypertriglyceridemia, hypercholesterolemia, and high LDL were 100% (38/38), 65.2% (30/46), 62.2% (28/45), 94.3% (33/35), 100% (12/12), and 100% (12/12), respectively. (4) Changes in nutrient indicators: Compared with the preoperative nutrient levels, the hemoglobin and hematocrit levels were lower at 3 to 12 months after surgery, the total protein level was lower at 6 to 12 months after surgery, the albumin level was lower at 6 months after surgery, and the ferritin level was lower at 3 months after surgery. The differences were statistically ","PeriodicalId":23959,"journal":{"name":"中华胃肠外科杂志","volume":"27 9","pages":"945-952"},"PeriodicalIF":0.0,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142308667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A case report of Roux-en-Y gastric bypass combined with radical gastrectomy for severe obesity complicated with gastric cancer]. [Roux-en-Y胃旁路术联合根治性胃切除术治疗严重肥胖并发胃癌的病例报告]。
Q3 Medicine Pub Date : 2024-09-25 DOI: 10.3760/cma.j.cn441530-20231020-00142
J D Li, J C Zhang, J M Wu, Z Y Dong, N Cai, C C Wang
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引用次数: 0
[Clinical characteristics, treatment strategy, and clinical outcomes in type 2 intestinal failure]. [2型肠衰竭的临床特征、治疗策略和临床结果]。
Q3 Medicine Pub Date : 2024-09-25 DOI: 10.3760/cma.j.cn441530-20231222-00229
X L Ge, W L Qi, W Liu, H L Xu, L N Ye, Q Cao, N Li, W Zhou

Objective: To evaluate the characteristics, clinical management and clinical outcomes of type 2 intestinal failure (IF). Methods: A descriptive case-control study was carried out. The inclusion criteria were as follows: (1) the diagnosis of IF was performed according to the European Society for Parenteral and Enteral Nutrition (ESPEN) consensus statement. (2) using a requirement for parenteral nutrition (PN) of 28 days or more as surrogate marker. (3) a multidisciplinary team (MDT) included surgeons, nutritionist, pharmacist, stoma therapists, and critical care physicians. (4) complete laboratory data. Patients with type 1 and type 3 IF and those who do not cooperate with follow-up. All the data of 67 type II IF were collected from the database in Sir Run Run Shaw Hospital from Jan 2016 to Dec 2023. The pathophysiology, clinical management, and outcomes of type II IF were analyzed. Results: A total of 67 type II IF were included. The median age was 54 (15-83) with 43 males and 24 females. The body mass index was (17.5±3.8) kg/m2, the incidence of malnutrition was 67.2% (45/67), the incidence of sarcopenia was 74.6% (50/67), the median number of previous surgeries was 2.0 (1-13), and the median duration time of PN was 2.1 (1-12) months. The underlying disease of type 2 IF included 36 Crohn`s disease, 2 ulcerative colitis, 3 radiation enteritis, 2 intestinal Behcet's disease, 4 mesenteric infarction, 1 aggressive fibromatosis, 5 abdominal cocoon syndrome, 5 gastrointestinal perforation, 1 hernia, 4 intestinal dysmotility, and 4 other reasons (gastrointestinal tumor, trauma, and non-Hodgkin's lymphoma). According to the pathophysiology of IF, there were 33 intestinal fistula, 12 intestinal dysmotility, 6 mechanical obstruction, 13 short bowel syndrome, and 3 extensive small bowel mucosal disease. After treatment with MDT, 67 patients with type 2 IF received nutritional support therapy for intestinal rehabilitation treatment, of which 36 patients recovered with oral diet or enteral nutrition, 31 patients underwent reconstructive surgery after intestinal rehabilitation treatment failure. The median duration time of reconstructive surgery was 2.7 (1-9) months. 24 patients recovered intestinal autonomy after surgery, with 7 deaths, including 6 deaths due to abdominal infections and 1 case of intestinal dysmotility with abiotrophy and liver failure. Conclusion: Standardized multidisciplinary treatment plays an important role in type II intestinal failure, and it promotes patients with intestinal failure regain enteral autonomy.

目的评估 2 型肠功能衰竭(IF)的特征、临床管理和临床结果。方法: 采用描述性病例对照研究:进行了一项描述性病例对照研究。纳入标准如下(1) 根据欧洲肠外和肠内营养学会(ESPEN)的共识声明进行 IF 诊断。(2) 以需要肠外营养(PN)28 天或更长时间作为替代指标。(3) 多学科团队(MDT)包括外科医生、营养师、药剂师、造口治疗师和重症监护医生。(4) 完整的实验室数据。1 型和 3 型 IF 患者以及不配合随访的患者。从邵逸夫医院的数据库中收集了 2016 年 1 月至 2023 年 12 月期间 67 例 II 型 IF 的所有数据。分析了II型IF的病理生理学、临床治疗和预后。结果:共纳入 67 例 II 型 IF。中位年龄为 54 岁(15-83 岁),其中男性 43 人,女性 24 人。体重指数为(17.5±3.8)kg/m2,营养不良发生率为 67.2%(45/67),肌少症发生率为 74.6%(50/67),既往手术次数中位数为 2.0(1-13)次,PN 持续时间中位数为 2.1(1-12)个月。2 型 IF 的基础疾病包括:克罗恩病 36 例、溃疡性结肠炎 2 例、放射性肠炎 3 例、肠白塞氏病 2 例、肠系膜梗塞 4 例、侵袭性纤维瘤病 1 例、腹部蚕茧综合征 5 例、胃肠穿孔 5 例、疝气 1 例、肠道运动障碍 4 例以及其他原因 4 例(胃肠道肿瘤、外伤和非霍奇金淋巴瘤)。根据 IF 的病理生理学,有 33 例肠瘘、12 例肠运动障碍、6 例机械性梗阻、13 例短肠综合征和 3 例广泛的小肠粘膜病变。67 名 2 型 IF 患者在接受 MDT 治疗后,接受了肠道康复治疗的营养支持疗法,其中 36 名患者通过口服饮食或肠内营养康复,31 名患者在肠道康复治疗失败后接受了重建手术。重建手术的中位持续时间为 2.7(1-9)个月。24 名患者在手术后恢复了肠道自主功能,7 人死亡,其中 6 人死于腹部感染,1 人因肠道运动障碍并伴有非营养不良和肝功能衰竭而死亡。结论是规范化多学科治疗在 II 型肠衰竭中发挥着重要作用,可促进肠衰竭患者恢复肠道自主功能。
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引用次数: 0
[Membrane anatomy-toward a new era of pelvic surgery]. [膜解剖学--迈向盆腔手术新时代]。
Q3 Medicine Pub Date : 2024-09-25 DOI: 10.3760/cma.j.cn441530-20240704-00234
H L Liu, H H Jiang, M B Lin

The concept of membrane anatomy has been widely accepted and applied in clinical practice, but there are still many theoretical and practical conflicts. This article elucidates the fundamental concepts and manifestations of membrane anatomy, delineating its comprehensive integration of anatomical and surgical disciplines. Thereafter, this article specifically discusses its differences from the traditional anatomy and surgery, and then clarifies the important role of membrane anatomy as the third generation of surgical anatomy and the new surgical concept for the development of pelvic surgery.

膜解剖学的概念已被广泛接受并应用于临床实践,但仍存在许多理论和实践上的冲突。本文阐明了膜解剖学的基本概念和表现形式,划分了其与解剖学和外科学的全面融合。随后,本文具体论述了其与传统解剖学和外科学的区别,进而阐明了膜解剖学作为第三代外科解剖学和新的外科理念对盆腔外科发展的重要作用。
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引用次数: 0
[Shanghai consensus on the diagnosis and treatment of gastroesophageal reflux disease in patients undergoing sleeve gastrectomy(2024 edition)]. [袖状胃切除术患者胃食管反流病诊治上海共识(2024 年版)]。
Q3 Medicine Pub Date : 2024-09-25 DOI: 10.3760/cma.j.cn441530-20240819-00290

Morbid obesity and its accompanying diseases have become one of the most serious public health problems warranting global effort and bariatric and metabolic surgery is still the most effective method for long-term weight control. Among all bariatric and metabolic procedures, sleeve gastrectomy is currently the most widely used, but it is not a perfect procedure. One of the most serious issues that this surgical procedure faces is the possibility of worsening existing or developing de novo gastroesophageal reflux disease after surgery. Moreover, there is currently a lack of high-level clinical trial evidence on the diagnosis and treatment of gastroesophageal reflux disease in patients undergoing sleeve gastrectomy. Therefore, initiated by four domestic bariatric and metabolic surgery centers, 41 experts with rich experience in bariatric and metabolic surgery and diagnosis and treatment of gastroesophageal reflux disease from China, Japan, and South Korea reached a consensus on the diagnosis and treatment of gastroesophageal reflux disease in sleeve gastrectomy patients using the Delphi method. There are a total of 59 consultation questions in this consensus, of which 44 have reached a consensus. We hope that this consensus can not only serve as a reference for clinical diagnosis and treatment, but also provide more possible directions for future high-quality clinical research.

病态肥胖及其伴随疾病已成为最严重的公共卫生问题之一,需要全球共同努力,而减肥和代谢手术仍然是长期控制体重的最有效方法。在所有减肥和代谢手术中,袖带胃切除术是目前应用最广泛的手术,但它并不是一种完美的手术。该手术面临的一个最严重的问题是,术后现有的或新发的胃食管反流病可能会恶化。此外,关于袖状胃切除术患者胃食管反流病的诊断和治疗,目前还缺乏高水平的临床试验证据。为此,由国内四家减重与代谢外科中心发起,来自中国、日本、韩国的41位在减重与代谢外科及胃食管反流病诊治方面具有丰富经验的专家,采用德尔菲法就袖状胃切除术患者胃食管反流病的诊治达成共识。该共识共有 59 个咨询问题,其中 44 个已达成共识。我们希望这份共识不仅能为临床诊断和治疗提供参考,也能为未来高质量的临床研究提供更多可能的方向。
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引用次数: 0
[Lymph distant and skip metastasis of esophageal cancer based on the membrane anatomy theory]. [基于膜解剖理论的食管癌淋巴远处转移和跳过转移]。
Q3 Medicine Pub Date : 2024-09-25 DOI: 10.3760/cma.j.cn441530-20240710-00241
G J Wang

This study elaborates the essence of distant lymph node metastasis and skip metastasis of esophageal cancer according to the membrane anatomy theory. Lymph distant metastasis of esophageal cancer is essentially the phenomenon of cancer cells shedding from the primary focus of esophageal cancer and transferring along the direction of lymphatic drainage to the root of the esophageal mesentery. Because the metastasis is relatively distant, it is called distant metastasis. Despite the long distance, this metastasis is still limited to the envelope-like-membrane structure of the esophageal mesentery and belongs to the category of mesangial carcinoma. The lymph node skip metastasis of esophageal cancer refers to the process in which esophageal cancer cells detach from the primary lesion and migrate along the lymphatic drainage direction within the envelope-like-membrane structure of the mesentery to the central lymph nodes at the root of the mesentery. During this metastatic process, the surrounding mesenteric lymph nodes which are tightly attached to the esophagus will not be affected by cancer metastasis because of the isolation barrier effect of the envelope-like membrane structure of the esophageal mesentery. Applying the theory of membrane anatomy to esophageal cancer radical surgery will make the surgery more scientific, reasonable, and standardized, and is expected to achieve dual benefits of both surgical and oncological effects in esophageal cancer radical surgery.

本研究根据膜解剖学理论,阐述了食管癌远处淋巴结转移和跳淋巴结转移的本质。食管癌淋巴远处转移的本质是癌细胞从食管癌原发灶脱落,沿淋巴引流方向转移到食管系膜根部的现象。由于转移距离相对较远,因此称为远处转移。尽管距离较远,但这种转移仍局限于食管系膜的包膜样结构,属于系膜癌的范畴。食管癌的淋巴结跳过转移是指食管癌细胞脱离原发病灶,沿着系膜包膜样结构内的淋巴引流方向转移到系膜根部中央淋巴结的过程。在这一转移过程中,周围紧贴食管的肠系膜淋巴结由于食管系膜包膜样结构的隔离屏障作用,不会受到癌细胞转移的影响。将膜解剖学理论应用于食管癌根治术,将使手术更加科学、合理、规范,有望实现食管癌根治术的手术效果和肿瘤效果的双重效益。
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引用次数: 0
[Distribution pattern of the rectal circumferential fascia and its clinical significance: An anatomical study]. [直肠周筋膜的分布模式及其临床意义:解剖学研究]。
Q3 Medicine Pub Date : 2024-09-25 DOI: 10.3760/cma.j.cn441530-20240710-00242
X J Wang, Y Deng, Z F Zheng, Y Huang, P Chi
<p><p><b>Objective:</b> To investigate the pattern of distribution of the circumferential fascia of the rectum and elucidate its clinical implications. <b>Methods:</b> In this descriptive study, we examined the gross anatomy of four male hemipelvic cadaveric specimens from the Department of Anatomy at Fujian Medical University and the histological features of 16 fresh postoperative specimens from patients who had undergone total mesorectal excision for rectal cancer at the Department of Colorectal Surgery, Union Hospital, Fujian Medical University, between January and December 2022. The resultant combination of gross anatomical and histological features was employed to assess the following areas: (1)the morphology of the anterior mesorectum and fascia at the peritoneal reflection; (2)the caudal attachment point of Denonvilliers' fascia; (3) the fusion area of the pelvic plexus and the pre-hypogastric fascia; (4)the lateral and posterior attachment edges of the rectosacral fascia; and (5) selected histological features. <b>Results:</b> Our findings were as follows. (1) At the peritoneal reflection, the anterior mesorectum forms a triangular fat pad with a dense fascial structure. The base of this pad extends anteriorly across the most caudal point of the peritoneal reflection, with Denonvilliers' fascia originating from the anterior side of the triangle, near the bladder side of the peritoneum craniad to the peritoneal reflection. (2) The caudal attachment of Denonvilliers' fascia is at the angle between the seminal vesicles, the ampulla of the vas deferens, and the prostate. It adheres tightly to the prostatic capsule and vascular bundles pass through its cephalic side. (3) The pre-hypogastric fascia transitions laterally to merge with Denonvilliers' fascia; its middle part being inseparable from the main body of the pelvic plexus, which gives rise to the nerves that innervate the rectum. (4) The rectosacral fascia is formed by fusion of the fascia propria with the pre-hypogastric fascia. The resultant fused fascia bifurcates into two leaves on the right side; the outer leaf being the pre-hypogastric fascia and the inner leaf the fascia propria. (5) Histologically, the peritoneal reflection zone shows cuboidal epithelium of the peritoneum at its lowest point with no detectable origin of Denonvilliers' fascia. The anterior side of the peritoneal reflection, from which Denonvilliers' fascia originates, has a dense double-layered fascial structure comprising thick collagen fiber (16/16). The fascia propria exhibits a thinner and looser collagen fiber structure and its origin varies between individuals, 13/16 originating together with Denonvilliers' fascia from the craniad side of the peritoneal reflection, and 3/16 originating separately from the most caudal point of the peritoneal reflection. The caudal edge of Denonvilliers' fascia has a double-layered fascial structure with multiple S100-stained areas. The posterior edge of the rectosacral fascia
研究目的研究直肠周缘筋膜的分布模式,并阐明其临床意义。方法在这项描述性研究中,我们对福建医科大学解剖学系的四具男性半骨盆尸体标本进行了大体解剖学检查,并对福建医科大学附属协和医院结直肠外科在 2022 年 1 月至 12 月期间接受直肠癌全直肠系膜切除术的 16 例新鲜术后标本进行了组织学特征检查。结合大体解剖学和组织学特征,对以下方面进行了评估:(1)直肠系膜前部和腹膜反射处筋膜的形态;(2)Denonvilliers筋膜的尾部附着点;(3)骨盆神经丛和下腹前筋膜的融合区;(4)直骶筋膜的外侧和后方附着边缘;以及(5)部分组织学特征。结果:我们的研究结果如下(1)在腹膜反射处,直肠系膜前部形成一个三角形脂肪垫,上面有致密的筋膜结构。该脂肪垫的基底向前方延伸,穿过腹膜反面的最尾端,Denonvilliers 筋膜起源于三角形的前侧,靠近腹膜反面前方的膀胱侧。(2)Denonvilliers 筋膜的尾部附着点位于精囊、输精管安瓿和前列腺之间的夹角处。它紧贴前列腺囊,血管束穿过其头侧。(3) 下腹前筋膜向侧方过渡,与德农维利耶筋膜合并;其中间部分与骨盆神经丛的主体密不可分,骨盆神经丛产生了支配直肠的神经。 (4) 直骶筋膜由固有筋膜与下腹前筋膜融合而成。融合后的筋膜在右侧分叉为两叶,外叶为下腹前筋膜,内叶为固有筋膜。(5)组织学上,腹膜反射区的最低点显示腹膜的立方上皮,没有发现德农维利耶筋膜的起源。腹膜反射区的前侧是 Denonvilliers 筋膜的发源地,有一个由厚胶原纤维(16/16)组成的致密双层筋膜结构。腹膜固有筋膜的胶原纤维结构更薄、更松散,其起源因个体而异,13/16 与 Denonvilliers 筋膜一起起源于腹膜反射的前侧,3/16 单独起源于腹膜反射的最尾端。Denonvilliers 筋膜的尾部边缘具有双层筋膜结构,并有多个 S100 染色区域。直骶筋膜后缘具有融合的筋膜结构,在高倍放大镜下可清楚地观察到来源于前胃筋膜的胶原纤维之间有粗大的神经纤维。直骶筋膜外侧边缘向内部延伸,保持了固有筋膜的完整性。结论:在这项研究中,我们通过尸体解剖和术后标本的组织学检查,研究了直肠周缘筋膜的分布模式。我们发现,直肠系膜前部形成了一个三角形脂肪垫,可作为在 Denonvilliers 筋膜前方解剖的参考,方法是在腹膜反光上方 1 厘米处切开。尾侧的 Denonvilliers 筋膜与前列腺囊融合区域有丰富的神经血管束,这与前列腺后平面的传统观点相悖。这一发现支持了在精囊底部上方 0.5 厘米处切开 Denonvilliers 筋膜的做法。固有筋膜与下腹前筋膜在后方融合形成直骶筋膜,直骶筋膜在直肠两侧分叉为两叶,内叶为固有筋膜,外叶为下腹前筋膜。这些筋膜向前方过渡成为德农维利耶筋膜,并与两侧骨盆神经丛的主体密集融合。这些发现为保护盆腔神经丛和胃下神经提供了理论依据,方法是横断 Denonvilliers 筋膜,然后从上到下(即从前方到尾部)解剖,最终导致横断前胃筋膜。
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引用次数: 0
[Learning curve for a five-step procedure, transthoracic single-port assisted laparoscopic transabdominal diaphragmatic approach, for Siewert type II adenocarcinoma of the esophagogastric junction]. [经胸单孔辅助腹腔镜经腹横膈膜入路治疗食管胃交界处 Siewert II 型腺癌五步手术的学习曲线]。
Q3 Medicine Pub Date : 2024-09-25 DOI: 10.3760/cma.j.cn441530-20240116-00028
H P Zeng, Y H Chen, L J Luo, Z J Zhang, Z Y Lin, Y Chen, Y H Peng, T Wang, Y S Zheng, W W Xiong, W Wang
<p><p><b>Objective:</b> To investigate the learning curve for a five-step procedure, namely, a transthoracic single-port assisted laparoscopic transabdominal diaphragmatic approach, for Siewert type II adenocarcinoma of the esophagogastric junction. <b>Methods:</b> In this retrospective cohort study, we analyzed relevant clinical data of 66 patients with Siewert type II adenocarcinoma of the esophagogastric junction who had undergone the five-step procedure performed by the same surgeon in the Gastrointestinal Surgery Department of Guangdong Provincial Hospital of Chinese Medicine from May 2017 to April 2023. The learning curve were plotted using cumulative summation analysis and selected indicators, including intraoperative blood loss, duration of surgery, time to first flatus, time to first tolerance of liquid food, length of hospital stay, and incidence of perioperative complications at different stages were compared. The data were analyzed using SPSS 24.0 statistical software. Numerical data are presented as cases (%) and data were analyzed using the χ<sup>2</sup> test or Fisher's exact test. Normally distributed measurement data are presented as <i>x±s</i>, and independent sample t-testing was performed for inter group comparison. Non-normally distributed measurement data are presented as <i>M</i>(<i>Q</i><sub>1</sub>, <i>Q</i><sub>3</sub>) and the Mann-Whitney U test was used for inter group comparison. <b>Results:</b> The five-step procedure had been successfully completed without switching to open surgery in all 66 study patients. There were no perioperative deaths, blood loss was 100 (50, 200) mL and duration of surgery 329.4±87.3 minutes. The equation of optimal fit for the duration of surgery was y=0.031x<sup>3</sup>-4.4757x<sup>2</sup>+164.97x-264.4 (<i>P</i><0.001, <i>R</i><sup>2</sup>=0.9797). The cumulative summation learning curve reached a vertex when 25 surgical procedures had accumulated. Using 25 cases as the cut-off, we divided the learning curves into learning and proficiency periods and patients into learning (25) and proficiency period groups (41). There were no statistically significant differences between the two groups of patients in sex, age, body mass index, American Society of Anesthesiologists score, history of abdominal surgery, comorbidities, preoperative neoadjuvant therapy, maximum tumor diameter, surgical procedure, or T and N stage of tumor (<i>P</i>>0.05). The following factors differed significantly (all <i>P</i><0.05) between the learning and proficiency stages: in the latter there was less intraoperative blood loss (100 [50, 100] ml vs. 200 [100, 200] ml, <i>U</i>=-3.940, <i>P</i><0.001), shorter duration of surgery ([289.8±50.7] minutes vs. [394.4±96.0] minutes, <i>t</i>=5.034, <i>P</i><0.001), more mediastinal lymph nodes removed (5 [2, 8] vs. 2 [1, 5], <i>U</i>=-2.518, <i>P</i>=0.012), earlier time to first flatus (2 [2, 3] days vs. 4 [3, 6] days, <i>U</i>=-4.016, <i>P</i><0.001), earlier time to first
目的研究经胸单孔辅助腹腔镜经腹膈肌入路治疗食管胃交界处 Siewert II 型腺癌五步手术的学习曲线。方法:在这项回顾性队列研究中,我们分析了2017年5月至2023年4月期间广东省中医院胃肠外科由同一外科医生实施五步手术的66例食管胃交界处Siewert II型腺癌患者的相关临床资料。采用累积求和分析法绘制学习曲线,并选取不同阶段的术中失血量、手术时间、首次排气时间、首次耐受流质食物时间、住院时间、围术期并发症发生率等指标进行比较。数据使用 SPSS 24.0 统计软件进行分析。数值数据以病例数(%)表示,数据分析采用χ2检验或费雪精确检验。正态分布的测量数据以 x±s 表示,组间比较采用独立样本 t 检验。非正态分布的测量数据以 M(Q1,Q3)表示,组间比较采用 Mann-Whitney U 检验。结果所有 66 名研究对象都成功完成了五步手术,没有改用开放手术。围手术期无死亡病例,失血量为 100(50,200)毫升,手术时间为(329.4±87.3)分钟。手术时间的最佳拟合方程为y=0.031x3-4.4757x2+164.97x-264.4(PR2=0.9797)。累计求和学习曲线在累计完成 25 例手术时达到顶点。以 25 例为分界线,我们将学习曲线分为学习期和熟练期,并将患者分为学习期组(25 例)和熟练期组(41 例)。两组患者在性别、年龄、体重指数、美国麻醉医师协会评分、腹部手术史、合并症、术前新辅助治疗、肿瘤最大直径、手术方式、肿瘤T期和N期等方面均无统计学差异(P>0.05)。以下因素有显著差异(全部PU=-3.940,Pt=5.034,PU=-2.518,P=0.012):首次排气时间更早(2 [2, 3] 天 vs. 4 [3, 6] 天,U=-4.016,PU=-2.922,P=0.003),住院时间更短(8 [8, 10] 天 vs. 10 [9, 12] 天,U=-2.028,P=0.043)。两组的手术并发症发生率无明显差异(P=0.238)。结论对食管胃交界处的 Siewert II 型腺癌患者采用五步手术法治疗食管胃交界处的腺癌,只要完成 25 次手术,就能取得满意的疗效。
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中华胃肠外科杂志
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